1.0M XNAS Volume
XNAS 19 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 76.43 per share. | 03 Mar 2025 | 2,407 | 36,042 (0%) | 0% | 76.4 | 183,967 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 59,781 | 121,424 (0%) | 0% | 0 | Common Stock | |
| Waleed Hassanein | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2025 | 90,185 | 90,185 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 17,606 | 38,449 (0%) | 0% | 0 | Common Stock | |
| Tamer Khayal | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 26,499 | 26,499 | - | - | Stock Option (Right to Buy) | |
| Nicholas Corcoran | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 19,079 | 19,079 | - | - | Stock Option (Right to Buy) | |
| Nicholas Corcoran | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 12,676 | 33,781 (0%) | 0% | 0 | Common Stock | |
| Anil P. Ranganath | See remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 8,479 | 8,479 | - | - | Stock Option (Right to Buy) | |
| Anil P. Ranganath | See remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 5,634 | 14,641 (0%) | 0% | 0 | Common Stock | |
| Gerardo Hernandez | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 3,521 | 15,984 (0%) | 0% | 0 | Common Stock | |
| Gerardo Hernandez | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 5,299 | 5,299 | - | - | Stock Option (Right to Buy) | |
| Hernandez Gerardo | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2024 | 18,922 | 18,922 | - | - | Stock Option (Right to Buy) | |
| Hernandez Gerardo | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Dec 2024 | 12,463 | 12,463 (0%) | 0% | 0 | Common Stock | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2024 | 1,084 | 16,250 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 86.40 per share. | 02 Dec 2024 | 1,084 | 20,843 (0%) | 0% | 86.4 | 93,658 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 02 Dec 2024 | 1,084 | 21,927 (0%) | 0% | 13.3 | 14,396 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 11 Nov 2024 | 1,458 | 22,301 (0%) | 0% | 38.5 | 56,075 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Nov 2024 | 1,458 | 5,834 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.04 per share. | 11 Nov 2024 | 1,458 | 20,843 (0%) | 0% | 90.0 | 131,278 | Common Stock |
| Edward M. Basile | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2024 | 6,750 | 0 | - | - | Stock Option (Right to Buy) | |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 84.30 per share. | 05 Nov 2024 | 1,454 | 732 (0%) | 0% | 84.3 | 122,572 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 83.35 per share. | 05 Nov 2024 | 5,296 | 2,186 (0%) | 0% | 83.4 | 441,422 | Common Stock |
| Edward M. Basile | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.12 per share. | 05 Nov 2024 | 6,750 | 7,482 (0%) | 0% | 28.1 | 189,810 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 82.64 per share. | 01 Nov 2024 | 1,083 | 20,843 (0%) | 0% | 82.6 | 89,499 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 01 Nov 2024 | 1,083 | 21,926 (0%) | 0% | 13.3 | 14,382 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 1,083 | 17,334 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 132.82 per share. | 15 Oct 2024 | 3,518 | 63,143 (0%) | 0% | 132.8 | 467,261 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 131.91 per share. | 15 Oct 2024 | 3,607 | 66,661 (0%) | 0% | 131.9 | 475,799 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 15 Oct 2024 | 8,625 | 70,268 (0%) | 0% | 13.3 | 114,540 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2024 | 8,625 | 96,250 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 135.04 per share. | 15 Oct 2024 | 300 | 61,643 (0%) | 0% | 135.0 | 40,512 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 134.23 per share. | 15 Oct 2024 | 1,200 | 61,943 (0%) | 0% | 134.2 | 161,076 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 01 Oct 2024 | 1,458 | 22,301 (0%) | 0% | 38.5 | 56,075 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 1,083 | 18,417 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 417 | 12,098 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 1,458 | 7,292 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 154.86 per share. | 01 Oct 2024 | 134 | 20,843 (0%) | 0% | 154.9 | 20,751 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 153.75 per share. | 01 Oct 2024 | 20 | 20,977 (0%) | 0% | 153.8 | 3,075 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 152.28 per share. | 01 Oct 2024 | 80 | 20,997 (0%) | 0% | 152.3 | 12,182 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 151.20 per share. | 01 Oct 2024 | 80 | 21,077 (0%) | 0% | 151.2 | 12,096 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 150.38 per share. | 01 Oct 2024 | 318 | 21,157 (0%) | 0% | 150.4 | 47,821 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 149.59 per share. | 01 Oct 2024 | 523 | 21,475 (0%) | 0% | 149.6 | 78,236 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 147.98 per share. | 01 Oct 2024 | 80 | 21,998 (0%) | 0% | 148.0 | 11,838 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 146.90 per share. | 01 Oct 2024 | 900 | 22,078 (0%) | 0% | 146.9 | 132,210 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 146.15 per share. | 01 Oct 2024 | 823 | 22,978 (0%) | 0% | 146.1 | 120,281 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 01 Oct 2024 | 1,083 | 23,801 (0%) | 0% | 13.3 | 14,382 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.10 per share. | 01 Oct 2024 | 417 | 22,718 (0%) | 0% | 66.1 | 27,564 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2024 | 8,625 | 104,875 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 16 Sep 2024 | 8,625 | 70,268 (0%) | 0% | 13.3 | 114,540 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 151.10 per share. | 16 Sep 2024 | 908 | 69,360 (0%) | 0% | 151.1 | 137,199 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 152.30 per share. | 16 Sep 2024 | 1,865 | 67,495 (0%) | 0% | 152.3 | 284,040 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 153.32 per share. | 16 Sep 2024 | 3,155 | 64,340 (0%) | 0% | 153.3 | 483,725 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 154.16 per share. | 16 Sep 2024 | 1,383 | 62,957 (0%) | 0% | 154.2 | 213,203 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 155.65 per share. | 16 Sep 2024 | 688 | 62,269 (0%) | 0% | 155.6 | 107,087 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 156.48 per share. | 16 Sep 2024 | 626 | 61,643 (0%) | 0% | 156.5 | 97,956 | Common Stock |
| James R. Tobin | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 13 Sep 2024 | 18,000 | 18,000 (0%) | 0% | 0 | Common Stock | |
| James R. Tobin | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 13 Sep 2024 | 18,000 | 155,146 (0%) | 0% | 0 | Common Stock | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 03 Sep 2024 | 1,459 | 22,302 (0%) | 0% | 38.5 | 56,113 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 157.27 per share. | 03 Sep 2024 | 599 | 23,204 (0%) | 0% | 157.3 | 94,205 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 158.09 per share. | 03 Sep 2024 | 921 | 22,283 (0%) | 0% | 158.1 | 145,601 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 159.02 per share. | 03 Sep 2024 | 132 | 22,151 (0%) | 0% | 159.0 | 20,991 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 160.67 per share. | 03 Sep 2024 | 396 | 21,755 (0%) | 0% | 160.7 | 63,625 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 161.54 per share. | 03 Sep 2024 | 700 | 21,055 (0%) | 0% | 161.5 | 113,078 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 163.09 per share. | 03 Sep 2024 | 80 | 20,975 (0%) | 0% | 163.1 | 13,047 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 164.69 per share. | 03 Sep 2024 | 32 | 20,943 (0%) | 0% | 164.7 | 5,270 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 165.87 per share. | 03 Sep 2024 | 100 | 20,843 (0%) | 0% | 165.9 | 16,587 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 1,459 | 8,750 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 417 | 12,515 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 1,084 | 19,500 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 03 Sep 2024 | 1,084 | 23,803 (0%) | 0% | 13.3 | 14,396 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.10 per share. | 03 Sep 2024 | 417 | 22,719 (0%) | 0% | 66.1 | 27,564 | Common Stock |
| Nicholas Corcoran | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Aug 2024 | 2,190 | 15,442 | - | - | Stock Option (Right to Buy) | |
| Nicholas Corcoran | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Aug 2024 | 7,810 | 11,922 | - | - | Stock Option (Right to Buy) | |
| Nicholas Corcoran | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.10 per share. | 27 Aug 2024 | 7,810 | 28,915 (0%) | 0% | 66.1 | 516,241 | Common Stock |
| Nicholas Corcoran | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 83.14 per share. | 27 Aug 2024 | 2,190 | 31,105 (0%) | 0% | 83.1 | 182,077 | Common Stock |
| Nicholas Corcoran | See Remarks | Sale of securities on an exchange or to another person at price $ 176.02 per share. | 27 Aug 2024 | 10,000 | 21,105 (0%) | 0% | 176.0 | 1,760,200 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Aug 2024 | 20,000 | 265,714 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 175.00 per share. | 21 Aug 2024 | 25,000 | 61,643 (0%) | 0% | 175 | 4,375,000 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 21 Aug 2024 | 25,000 | 86,643 (0%) | 0% | 16.1 | 403,500 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 171.03 per share. | 21 Aug 2024 | 20,000 | 61,643 (0%) | 0% | 171.0 | 3,420,600 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 21 Aug 2024 | 20,000 | 81,643 (0%) | 0% | 16 | 320,000 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Aug 2024 | 25,000 | 153,000 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 15 Aug 2024 | 8,625 | 70,268 (0%) | 0% | 13.3 | 114,540 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2024 | 8,625 | 113,500 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 171.86 per share. | 15 Aug 2024 | 205 | 61,643 (0%) | 0% | 171.9 | 35,231 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 171.42 per share. | 15 Aug 2024 | 1,018 | 61,848 (0%) | 0% | 171.4 | 174,506 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 170.21 per share. | 15 Aug 2024 | 4,526 | 62,866 (0%) | 0% | 170.2 | 770,370 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 169.39 per share. | 15 Aug 2024 | 1,376 | 67,392 (0%) | 0% | 169.4 | 233,081 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 168.17 per share. | 15 Aug 2024 | 500 | 68,768 (0%) | 0% | 168.2 | 84,085 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 167.24 per share. | 15 Aug 2024 | 700 | 69,268 (0%) | 0% | 167.2 | 117,068 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 165.26 per share. | 15 Aug 2024 | 300 | 69,968 (0%) | 0% | 165.3 | 49,578 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 159.96 per share. | 08 Aug 2024 | 7,336 | 173,146 (0%) | 0% | 160.0 | 1,173,467 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 158.96 per share. | 08 Aug 2024 | 12,664 | 180,482 (0%) | 0% | 159.0 | 2,013,069 | Common Stock |
| Edward M. Basile | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.12 per share. | 06 Aug 2024 | 6,750 | 7,482 (0%) | 0% | 28.1 | 189,810 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 151.89 per share. | 06 Aug 2024 | 1,537 | 732 (0%) | 0% | 151.9 | 233,455 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 149.71 per share. | 06 Aug 2024 | 2,383 | 3,269 (0%) | 0% | 149.7 | 356,759 | Common Stock |
| Edward M. Basile | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2024 | 6,750 | 6,750 | - | - | Stock Option (Right to Buy) | |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 150.70 per share. | 06 Aug 2024 | 1,000 | 2,269 (0%) | 0% | 150.7 | 150,700 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 148.26 per share. | 06 Aug 2024 | 1,830 | 5,652 (0%) | 0% | 148.3 | 271,316 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 01 Aug 2024 | 1,458 | 22,301 (0%) | 0% | 38.5 | 56,075 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 166.00 per share. | 01 Aug 2024 | 14 | 20,843 (0%) | 0% | 166 | 2,324 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 164.98 per share. | 01 Aug 2024 | 84 | 20,857 (0%) | 0% | 165.0 | 13,858 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 163.66 per share. | 01 Aug 2024 | 32 | 20,941 (0%) | 0% | 163.7 | 5,237 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 161.99 per share. | 01 Aug 2024 | 116 | 20,973 (0%) | 0% | 162.0 | 18,791 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 161.09 per share. | 01 Aug 2024 | 126 | 21,089 (0%) | 0% | 161.1 | 20,297 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 159.86 per share. | 01 Aug 2024 | 329 | 21,215 (0%) | 0% | 159.9 | 52,594 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 417 | 12,932 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 158.88 per share. | 01 Aug 2024 | 240 | 21,544 (0%) | 0% | 158.9 | 38,131 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 157.83 per share. | 01 Aug 2024 | 252 | 21,784 (0%) | 0% | 157.8 | 39,773 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 157.00 per share. | 01 Aug 2024 | 124 | 22,036 (0%) | 0% | 157 | 19,468 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 1,083 | 20,584 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 1,458 | 10,209 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 155.69 per share. | 01 Aug 2024 | 380 | 22,160 (0%) | 0% | 155.7 | 59,162 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 154.86 per share. | 01 Aug 2024 | 510 | 22,540 (0%) | 0% | 154.9 | 78,979 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 153.81 per share. | 01 Aug 2024 | 483 | 23,050 (0%) | 0% | 153.8 | 74,290 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 152.71 per share. | 01 Aug 2024 | 154 | 23,533 (0%) | 0% | 152.7 | 23,517 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 151.80 per share. | 01 Aug 2024 | 114 | 23,687 (0%) | 0% | 151.8 | 17,305 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 01 Aug 2024 | 1,083 | 23,801 (0%) | 0% | 13.3 | 14,382 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.10 per share. | 01 Aug 2024 | 417 | 22,718 (0%) | 0% | 66.1 | 27,564 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 147.28 per share. | 15 Jul 2024 | 300 | 61,643 (0%) | 0% | 147.3 | 44,184 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 146.39 per share. | 15 Jul 2024 | 2,342 | 61,943 (0%) | 0% | 146.4 | 342,845 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 145.54 per share. | 15 Jul 2024 | 2,046 | 64,285 (0%) | 0% | 145.5 | 297,775 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 144.34 per share. | 15 Jul 2024 | 2,540 | 66,331 (0%) | 0% | 144.3 | 366,624 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 143.61 per share. | 15 Jul 2024 | 1,397 | 68,871 (0%) | 0% | 143.6 | 200,623 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 15 Jul 2024 | 8,625 | 70,268 (0%) | 0% | 13.3 | 114,540 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 8,625 | 122,125 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 01 Jul 2024 | 1,458 | 22,301 (0%) | 0% | 38.5 | 56,075 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 1,083 | 21,667 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 417 | 13,349 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 1,458 | 11,667 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 153.48 per share. | 01 Jul 2024 | 160 | 20,843 (0%) | 0% | 153.5 | 24,557 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 152.53 per share. | 01 Jul 2024 | 582 | 21,003 (0%) | 0% | 152.5 | 88,772 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 151.33 per share. | 01 Jul 2024 | 1,106 | 21,585 (0%) | 0% | 151.3 | 167,371 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 150.70 per share. | 01 Jul 2024 | 1,000 | 22,691 (0%) | 0% | 150.7 | 150,700 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 149.57 per share. | 01 Jul 2024 | 110 | 23,691 (0%) | 0% | 149.6 | 16,453 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 01 Jul 2024 | 1,083 | 23,801 (0%) | 0% | 13.3 | 14,382 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.10 per share. | 01 Jul 2024 | 417 | 22,718 (0%) | 0% | 66.1 | 27,564 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 14 Jun 2024 | 8,625 | 70,268 (0%) | 0% | 13.3 | 114,540 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 144.52 per share. | 14 Jun 2024 | 100 | 61,643 (0%) | 0% | 144.5 | 14,452 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2024 | 8,625 | 130,750 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 143.65 per share. | 14 Jun 2024 | 400 | 61,743 (0%) | 0% | 143.7 | 57,460 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 142.68 per share. | 14 Jun 2024 | 2,675 | 62,143 (0%) | 0% | 142.7 | 381,669 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 141.62 per share. | 14 Jun 2024 | 3,836 | 64,818 (0%) | 0% | 141.6 | 543,254 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 140.42 per share. | 14 Jun 2024 | 1,614 | 68,654 (0%) | 0% | 140.4 | 226,638 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 138.08 per share. | 05 Jun 2024 | 1,193 | 732 (0%) | 0% | 138.1 | 164,729 | Common Stock |
| Anil P. Ranganath | See remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2024 | 4,289 | 10,420 | - | - | Stock Option (Right to Buy) | |
| Anil P. Ranganath | See remarks | Sale of securities on an exchange or to another person at price $ 152.20 per share. | 05 Jun 2024 | 4,289 | 8,893 (0%) | 0% | 152.2 | 652,786 | Common Stock |
| Anil P. Ranganath | See remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 93.88 per share. | 05 Jun 2024 | 4,289 | 13,182 (0%) | 0% | 93.9 | 402,651 | Common Stock |
| Anil P. Ranganath | See remarks | Sale of securities on an exchange or to another person at price $ 135.21 per share. | 05 Jun 2024 | 703 | 8,809 (0%) | 0% | 135.2 | 95,053 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 03 Jun 2024 | 2,060 | 23,359 (0%) | 0% | 38.5 | 79,228 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 2,060 | 15,417 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 135.93 per share. | 03 Jun 2024 | 2,060 | 21,299 (0%) | 0% | 135.9 | 280,016 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 1,459 | 13,125 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 135.97 per share. | 03 Jun 2024 | 457 | 20,843 (0%) | 0% | 136.0 | 62,138 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 134.66 per share. | 03 Jun 2024 | 152 | 21,300 (0%) | 0% | 134.7 | 20,468 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 133.67 per share. | 03 Jun 2024 | 567 | 21,452 (0%) | 0% | 133.7 | 75,791 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 132.71 per share. | 03 Jun 2024 | 921 | 22,019 (0%) | 0% | 132.7 | 122,226 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 131.87 per share. | 03 Jun 2024 | 539 | 22,940 (0%) | 0% | 131.9 | 71,078 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 130.79 per share. | 03 Jun 2024 | 219 | 23,479 (0%) | 0% | 130.8 | 28,643 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 129.92 per share. | 03 Jun 2024 | 105 | 23,698 (0%) | 0% | 129.9 | 13,642 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 03 Jun 2024 | 1,084 | 23,803 (0%) | 0% | 13.3 | 14,396 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.10 per share. | 03 Jun 2024 | 417 | 22,719 (0%) | 0% | 66.1 | 27,564 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 03 Jun 2024 | 1,459 | 22,302 (0%) | 0% | 38.5 | 56,113 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 417 | 13,766 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 1,084 | 22,750 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 141.27 per share. | 29 May 2024 | 2,000 | 21,299 (0%) | 0% | 141.3 | 282,540 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2024 | 5,000 | 23,167 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2024 | 5,000 | 17,477 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2024 | 2,000 | 84 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 141.80 per share. | 29 May 2024 | 8,655 | 21,299 (0%) | 0% | 141.8 | 1,227,279 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2024 | 5,000 | 15,022 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 141.06 per share. | 29 May 2024 | 9,345 | 29,954 (0%) | 0% | 141.1 | 1,318,206 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.10 per share. | 29 May 2024 | 5,000 | 39,299 (0%) | 0% | 66.1 | 330,500 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 83.14 per share. | 29 May 2024 | 1,000 | 34,299 (0%) | 0% | 83.1 | 83,140 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 29 May 2024 | 5,000 | 33,299 (0%) | 0% | 13.3 | 66,400 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2024 | 1,000 | 17,690 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 29 May 2024 | 5,000 | 28,299 (0%) | 0% | 38.5 | 192,300 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 29 May 2024 | 2,000 | 23,299 (0%) | 0% | 16.1 | 32,280 | Common Stock |
| David Weill | Director | Sale of securities on an exchange or to another person at price $ 141.65 per share. | 29 May 2024 | 1,193 | 10,732 (0%) | 0% | 141.6 | 168,988 | Common Stock |
| Edwin M. Kania | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 1,154 | 1,154 | - | - | Stock Option (Right to Buy) | |
| Edwin M. Kania | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 732 | 258,676 (1%) | 0% | 0 | Common Stock | |
| James R. Tobin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 1,154 | 1,154 | - | - | Stock Option (Right to Buy) | |
| James R. Tobin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 732 | 1,925 (0%) | 0% | 0 | Common Stock | |
| Merilee Raines | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 732 | 1,925 (0%) | 0% | 0 | Common Stock | |
| Merilee Raines | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 1,154 | 1,154 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Gunderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 732 | 1,925 (0%) | 0% | 0 | Common Stock | |
| Thomas J. Gunderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 1,154 | 1,154 | - | - | Stock Option (Right to Buy) | |
| Stephanie Lovell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 732 | 1,925 (0%) | 0% | 0 | Common Stock | |
| Stephanie Lovell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 1,154 | 1,154 | - | - | Stock Option (Right to Buy) | |
| Edward M. Basile | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 1,154 | 1,154 | - | - | Stock Option (Right to Buy) | |
| Edward M. Basile | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 732 | 1,925 (0%) | 0% | 0 | Common Stock | |
| David Weill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 1,154 | 1,154 | - | - | Stock Option (Right to Buy) | |
| David Weill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 732 | 11,925 (0%) | 0% | 0 | Common Stock | |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 136.26 per share. | 15 May 2024 | 744 | 61,643 (0%) | 0% | 136.3 | 101,377 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 133.42 per share. | 15 May 2024 | 300 | 69,968 (0%) | 0% | 133.4 | 40,026 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 134.69 per share. | 15 May 2024 | 2,100 | 67,868 (0%) | 0% | 134.7 | 282,849 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 135.54 per share. | 15 May 2024 | 5,481 | 62,387 (0%) | 0% | 135.5 | 742,895 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 15 May 2024 | 8,625 | 70,268 (0%) | 0% | 13.3 | 114,540 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2024 | 8,625 | 139,375 | - | - | Stock Option (Right to Buy) | |
| David Weill | Director | Sale of securities on an exchange or to another person at price $ 129.82 per share. | 10 May 2024 | 2,500 | 11,193 (0%) | 0% | 129.8 | 324,550 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 128.43 per share. | 07 May 2024 | 2,130 | 6,220 (0%) | 0% | 128.4 | 273,556 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 132.34 per share. | 07 May 2024 | 816 | 1,193 (0%) | 0% | 132.3 | 107,989 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 131.34 per share. | 07 May 2024 | 1,100 | 2,009 (0%) | 0% | 131.3 | 144,474 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 130.31 per share. | 07 May 2024 | 885 | 3,109 (0%) | 0% | 130.3 | 115,324 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 129.80 per share. | 07 May 2024 | 2,226 | 3,994 (0%) | 0% | 129.8 | 288,935 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 06 May 2024 | 30,000 | 91,643 (0%) | 0% | 13.3 | 398,400 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 130.07 per share. | 06 May 2024 | 30,000 | 61,643 (0%) | 0% | 130.1 | 3,902,100 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 May 2024 | 30,000 | 148,000 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 06 May 2024 | 15,000 | 38,299 (0%) | 0% | 38.5 | 576,900 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 May 2024 | 15,000 | 22,477 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 128.00 per share. | 06 May 2024 | 15,000 | 23,299 (0%) | 0% | 128 | 1,920,000 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 130.07 per share. | 06 May 2024 | 5,839 | 9,792 (0%) | 0% | 130.1 | 759,479 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 May 2024 | 5,839 | 14,183 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.10 per share. | 06 May 2024 | 5,839 | 15,631 (0%) | 0% | 66.1 | 385,958 | Common Stock |
| Nicholas Corcoran | See Remarks | Sale of securities on an exchange or to another person at price $ 129.91 per share. | 06 May 2024 | 3,222 | 21,105 (0%) | 0% | 129.9 | 418,570 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 125.26 per share. | 03 May 2024 | 6,895 | 193,146 (0%) | 0% | 125.3 | 863,668 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 124.76 per share. | 03 May 2024 | 5,130 | 200,041 (0%) | 0% | 124.8 | 640,019 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 110.00 per share. | 01 May 2024 | 2,000 | 205,171 (0%) | 0% | 110 | 220,000 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 108.47 per share. | 01 May 2024 | 100 | 207,171 (0%) | 0% | 108.5 | 10,847 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 106.89 per share. | 01 May 2024 | 1,704 | 207,271 (0%) | 0% | 106.9 | 182,141 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 105.70 per share. | 01 May 2024 | 11,236 | 208,975 (0%) | 0% | 105.7 | 1,187,645 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 120.64 per share. | 01 May 2024 | 6,140 | 67,947 (0%) | 0% | 120.6 | 740,730 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 120.25 per share. | 01 May 2024 | 22,500 | 74,087 (0%) | 0% | 120.3 | 2,705,625 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 114.17 per share. | 01 May 2024 | 23,500 | 96,587 (0%) | 0% | 114.2 | 2,682,995 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 110.00 per share. | 01 May 2024 | 6,800 | 120,087 (0%) | 0% | 110 | 748,000 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 107.57 per share. | 01 May 2024 | 424 | 126,887 (0%) | 0% | 107.6 | 45,610 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 106.51 per share. | 01 May 2024 | 91 | 127,311 (0%) | 0% | 106.5 | 9,692 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 01 May 2024 | 56,000 | 130,087 (0%) | 0% | 13.3 | 743,680 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 105.56 per share. | 01 May 2024 | 2,685 | 127,402 (0%) | 0% | 105.6 | 283,429 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2024 | 56,000 | 178,000 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 122.67 per share. | 01 May 2024 | 82 | 61,643 (0%) | 0% | 122.7 | 10,059 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 122.16 per share. | 01 May 2024 | 6,222 | 61,725 (0%) | 0% | 122.2 | 760,080 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2024 | 1,083 | 23,834 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2024 | 1,458 | 14,584 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2024 | 45,326 | 16,042 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 120.01 per share. | 01 May 2024 | 7,388 | 0 (0%) | 0% | 120.0 | 886,634 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 111.50 per share. | 01 May 2024 | 500 | 7,388 (0%) | 0% | 111.5 | 55,750 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 110.06 per share. | 01 May 2024 | 6,888 | 7,888 (0%) | 0% | 110.1 | 758,093 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 123.66 per share. | 01 May 2024 | 100 | 9,792 (0%) | 0% | 123.7 | 12,366 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 122.53 per share. | 01 May 2024 | 17 | 9,892 (0%) | 0% | 122.5 | 2,083 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 121.74 per share. | 01 May 2024 | 532 | 9,909 (0%) | 0% | 121.7 | 64,766 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 120.86 per share. | 01 May 2024 | 512 | 10,441 (0%) | 0% | 120.9 | 61,880 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 119.85 per share. | 01 May 2024 | 1,799 | 10,953 (0%) | 0% | 119.8 | 215,610 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 118.93 per share. | 01 May 2024 | 1,259 | 12,752 (0%) | 0% | 118.9 | 149,733 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 117.96 per share. | 01 May 2024 | 738 | 14,011 (0%) | 0% | 118.0 | 87,054 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 116.80 per share. | 01 May 2024 | 326 | 14,749 (0%) | 0% | 116.8 | 38,077 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 113.16 per share. | 01 May 2024 | 100 | 15,075 (0%) | 0% | 113.2 | 11,316 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 109.83 per share. | 01 May 2024 | 15,892 | 15,175 (0%) | 0% | 109.8 | 1,745,418 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 109.28 per share. | 01 May 2024 | 3,027 | 31,067 (0%) | 0% | 109.3 | 330,791 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 107.84 per share. | 01 May 2024 | 3,477 | 34,094 (0%) | 0% | 107.8 | 374,960 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 107.00 per share. | 01 May 2024 | 12,250 | 37,571 (0%) | 0% | 107 | 1,310,750 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 105.96 per share. | 01 May 2024 | 23,231 | 49,821 (0%) | 0% | 106.0 | 2,461,557 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 01 May 2024 | 1,083 | 73,052 (0%) | 0% | 13.3 | 14,382 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 01 May 2024 | 1,458 | 71,969 (0%) | 0% | 38.5 | 56,075 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 01 May 2024 | 45,326 | 70,511 (0%) | 0% | 38.5 | 1,743,238 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 113.16 per share. | 01 May 2024 | 100 | 26,126 (0%) | 0% | 113.2 | 11,316 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 105.71 per share. | 01 May 2024 | 11,051 | 0 (0%) | 0% | 105.7 | 1,168,201 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 123.66 per share. | 01 May 2024 | 100 | 20,843 (0%) | 0% | 123.7 | 12,366 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 121.84 per share. | 01 May 2024 | 444 | 20,943 (0%) | 0% | 121.8 | 54,097 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 121.21 per share. | 01 May 2024 | 422 | 21,387 (0%) | 0% | 121.2 | 51,151 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 119.96 per share. | 01 May 2024 | 1,815 | 21,809 (0%) | 0% | 120.0 | 217,727 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 119.00 per share. | 01 May 2024 | 1,417 | 23,624 (0%) | 0% | 119 | 168,623 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 117.97 per share. | 01 May 2024 | 759 | 25,041 (0%) | 0% | 118.0 | 89,539 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 116.80 per share. | 01 May 2024 | 326 | 25,800 (0%) | 0% | 116.8 | 38,077 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 110.00 per share. | 01 May 2024 | 5,313 | 26,226 (0%) | 0% | 110 | 584,430 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 109.68 per share. | 01 May 2024 | 13,078 | 31,539 (0%) | 0% | 109.7 | 1,434,395 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 108.35 per share. | 01 May 2024 | 1,792 | 44,617 (0%) | 0% | 108.3 | 194,163 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 107.20 per share. | 01 May 2024 | 11,789 | 46,409 (0%) | 0% | 107.2 | 1,263,781 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 106.25 per share. | 01 May 2024 | 14,854 | 58,198 (0%) | 0% | 106.3 | 1,578,238 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 95.12 per share. | 17 Apr 2024 | 4,000 | 74,087 (0%) | 0% | 95.1 | 380,480 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 17 Apr 2024 | 4,000 | 78,087 (0%) | 0% | 13.3 | 53,120 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2024 | 4,000 | 234,000 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 95.09 per share. | 10 Apr 2024 | 12,000 | 74,087 (0%) | 0% | 95.1 | 1,141,080 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 10 Apr 2024 | 12,000 | 86,087 (0%) | 0% | 13.3 | 159,360 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Apr 2024 | 12,000 | 238,000 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 08 Apr 2024 | 4,388 | 29,573 (0%) | 0% | 16.1 | 70,822 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Apr 2024 | 7,171 | 61,368 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Apr 2024 | 8,341 | 0 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Apr 2024 | 4,388 | 8,341 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 91.11 per share. | 08 Apr 2024 | 4,980 | 25,185 (0%) | 0% | 91.1 | 453,728 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.14 per share. | 08 Apr 2024 | 10,532 | 30,165 (0%) | 0% | 90.1 | 949,354 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 08 Apr 2024 | 7,171 | 40,697 (0%) | 0% | 38.5 | 275,797 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 08 Apr 2024 | 8,341 | 33,526 (0%) | 0% | 16.1 | 134,624 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 08 Apr 2024 | 4,388 | 25,185 (0%) | 0% | 90 | 394,920 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 03 Apr 2024 | 5,053 | 30,238 (0%) | 0% | 13.3 | 67,104 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Apr 2024 | 2,917 | 12,729 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Apr 2024 | 2,030 | 24,917 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Apr 2024 | 5,053 | 26,947 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 80.36 per share. | 03 Apr 2024 | 4,947 | 25,185 (0%) | 0% | 80.4 | 397,541 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 03 Apr 2024 | 2,917 | 30,132 (0%) | 0% | 16.1 | 47,080 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 03 Apr 2024 | 2,030 | 27,215 (0%) | 0% | 13.3 | 26,958 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 80.06 per share. | 03 Apr 2024 | 5,053 | 25,185 (0%) | 0% | 80.1 | 404,543 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 01 Apr 2024 | 15,000 | 38,299 (0%) | 0% | 38.5 | 576,900 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2024 | 15,000 | 37,477 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 74.01 per share. | 01 Apr 2024 | 15,000 | 23,299 (0%) | 0% | 74.0 | 1,110,150 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 87.63 per share. | 08 Mar 2024 | 1,903 | 23,299 (0%) | 0% | 87.6 | 166,760 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2024 | 100 | 15,646 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 87.63 per share. | 08 Mar 2024 | 1,317 | 25,185 (0%) | 0% | 87.6 | 115,409 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.04 per share. | 08 Mar 2024 | 100 | 26,502 (0%) | 0% | 90.0 | 9,004 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 08 Mar 2024 | 100 | 26,602 (0%) | 0% | 16.1 | 1,614 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2024 | 15,000 | 52,477 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 04 Mar 2024 | 15,000 | 40,202 (0%) | 0% | 38.5 | 576,900 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 82.80 per share. | 04 Mar 2024 | 15,000 | 25,202 (0%) | 0% | 82.8 | 1,242,000 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 81.41 per share. | 01 Mar 2024 | 200 | 233,391 (1%) | 0% | 81.4 | 16,282 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 85.48 per share. | 01 Mar 2024 | 300 | 220,211 (1%) | 0% | 85.5 | 25,644 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 84.74 per share. | 01 Mar 2024 | 2,900 | 220,511 (1%) | 0% | 84.7 | 245,746 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 83.63 per share. | 01 Mar 2024 | 5,746 | 223,411 (1%) | 0% | 83.6 | 480,538 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 82.84 per share. | 01 Mar 2024 | 4,234 | 229,157 (1%) | 0% | 82.8 | 350,745 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 01 Mar 2024 | 10,000 | 36,502 (0%) | 0% | 13.3 | 132,800 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2024 | 10,000 | 32,000 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 85.18 per share. | 01 Mar 2024 | 1,234 | 26,502 (0%) | 0% | 85.2 | 105,112 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 84.26 per share. | 01 Mar 2024 | 424 | 27,736 (0%) | 0% | 84.3 | 35,726 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 83.64 per share. | 01 Mar 2024 | 3,632 | 28,160 (0%) | 0% | 83.6 | 303,780 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 82.28 per share. | 01 Mar 2024 | 1,842 | 31,792 (0%) | 0% | 82.3 | 151,560 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 81.49 per share. | 01 Mar 2024 | 2,868 | 33,634 (0%) | 0% | 81.5 | 233,713 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 12,127 | 25,202 (0%) | 0% | 0 | Common Stock | |
| Hassanein Waleed | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 56,645 | 56,645 | - | - | Stock Option (Right to Buy) | |
| Khayal Tamer | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 18,690 | 18,690 | - | - | Stock Option (Right to Buy) | |
| Gordon Stephen | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 18,690 | 18,690 | - | - | Stock Option (Right to Buy) | |
| Khayal Tamer | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 12,127 | 26,502 (0%) | 0% | 0 | Common Stock | |
| Hassanein Waleed | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 36,755 | 543,446 (2%) | 0% | 0 | Common Stock | |
| Corcoran Nicholas | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 17,632 | 17,632 | - | - | Stock Option (Right to Buy) | |
| Corcoran Nicholas | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 11,441 | 24,327 (0%) | 0% | 0 | Common Stock | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 16 Feb 2024 | 1,714 | 17,233 (0%) | 0% | 16.1 | 27,664 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 16 Feb 2024 | 2,858 | 14,375 (0%) | 0% | 90 | 257,220 | Common Stock |
| Khayal Tamer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 16 Feb 2024 | 250 | 14,375 (0%) | 0% | 90 | 22,500 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2024 | 250 | 15,746 | - | - | Stock Option (Right to Buy) | |
| Khayal Tamer | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 16 Feb 2024 | 250 | 14,625 (0%) | 0% | 16.1 | 4,035 | Common Stock |
| Khayal Tamer | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2024 | 1,714 | 15,996 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2024 | 1,144 | 0 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 16 Feb 2024 | 1,144 | 15,519 (0%) | 0% | 16 | 18,304 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 14 Feb 2024 | 776 | 14,375 (0%) | 0% | 90 | 69,840 | Common Stock |
| Khayal Tamer | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 14 Feb 2024 | 776 | 15,151 (0%) | 0% | 16 | 12,416 | Common Stock |
| Khayal Tamer | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2024 | 776 | 1,144 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 14 Feb 2024 | 3,050 | 17,425 (0%) | 0% | 16 | 48,800 | Common Stock |
| Khayal Tamer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.03 per share. | 14 Feb 2024 | 3,050 | 14,375 (0%) | 0% | 90.0 | 274,592 | Common Stock |
| Khayal Tamer | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2024 | 3,050 | 1,920 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2024 | 736 | 4,970 | - | - | Stock Option (Right to Buy) | |
| Khayal Tamer | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 07 Feb 2024 | 736 | 15,111 (0%) | 0% | 16 | 11,776 | Common Stock |
| Khayal Tamer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.09 per share. | 07 Feb 2024 | 736 | 14,375 (0%) | 0% | 90.1 | 66,306 | Common Stock |
| Edward Basile M. | Director | Sale of securities on an exchange or to another person at price $ 86.83 per share. | 06 Feb 2024 | 1,384 | 8,350 (0%) | 0% | 86.8 | 120,173 | Common Stock |
| M. Basile Edward | Director | Sale of securities on an exchange or to another person at price $ 86.27 per share. | 06 Feb 2024 | 5,773 | 9,734 (0%) | 0% | 86.3 | 498,037 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2024 | 8,833 | 28,167 | - | - | Stock Option (Right to Buy) | |
| Gordon Stephen | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2024 | 2,523 | 67,477 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 85.45 per share. | 01 Feb 2024 | 15,000 | 13,075 (0%) | 0% | 85.5 | 1,281,750 | Common Stock |
| Gordon Stephen | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 01 Feb 2024 | 2,523 | 28,075 (0%) | 0% | 38.5 | 97,035 | Common Stock |
| Gordon Stephen | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 01 Feb 2024 | 8,833 | 21,908 (0%) | 0% | 13.3 | 117,302 | Common Stock |
| Gordon Stephen | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2024 | 3,644 | 2,084 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 01 Feb 2024 | 3,644 | 25,552 (0%) | 0% | 16.1 | 58,814 | Common Stock |
| Khayal Tamer | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.09 per share. | 23 Jan 2024 | 2,330 | 14,375 (0%) | 0% | 90.1 | 209,910 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2024 | 2,330 | 5,706 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 23 Jan 2024 | 2,330 | 16,705 (0%) | 0% | 16 | 37,280 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 80.40 per share. | 16 Jan 2024 | 9,867 | 14,508 (0%) | 0% | 80.4 | 793,307 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 16 Jan 2024 | 10,000 | 24,375 (0%) | 0% | 13.3 | 132,800 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 10,000 | 42,000 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 81.06 per share. | 16 Jan 2024 | 133 | 14,375 (0%) | 0% | 81.1 | 10,781 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 15,000 | 37,000 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.28 per share. | 02 Jan 2024 | 15,000 | 28,075 (0%) | 0% | 13.3 | 199,200 | Common Stock |
| Gordon Stephen | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 77.07 per share. | 02 Jan 2024 | 15,000 | 13,075 (0%) | 0% | 77.1 | 1,156,050 | Common Stock |
| Provost Miriam | VP, Global Regulatory Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2023 | 415 | 7,811 | - | - | Stock Option (Right to Buy) | |
| Miriam Provost | VP, Global Regulatory Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2023 | 1,632 | 7,073 | - | - | Stock Option (Right to Buy) | |
| Provost Miriam | VP, Global Regulatory Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 13 Dec 2023 | 3,597 | 27,540 (0%) | 0% | 38.5 | 138,341 | Common Stock |
| Miriam Provost | VP, Global Regulatory Affairs | Sale of securities on an exchange or to another person at price $ 75.10 per share. | 13 Dec 2023 | 2,407 | 25,133 (0%) | 0% | 75.1 | 180,766 | Common Stock |
| Provost Miriam | VP, Global Regulatory Affairs | Sale of securities on an exchange or to another person at price $ 75.10 per share. | 13 Dec 2023 | 206 | 23,820 (0%) | 0% | 75.1 | 15,471 | Common Stock |
| Miriam Provost | VP, Global Regulatory Affairs | Gift of securities by or to the insider at price $ 0.00 per share. | 13 Dec 2023 | 1,785 | 23,348 (0%) | 0% | 0 | Common Stock | |
| Miriam Provost | VP, Global Regulatory Affairs | Sale of securities on an exchange or to another person at price $ 75.10 per share. | 13 Dec 2023 | 1,509 | 23,943 (0%) | 0% | 75.1 | 113,326 | Common Stock |
| Miriam Provost | VP, Global Regulatory Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.10 per share. | 13 Dec 2023 | 1,632 | 25,452 (0%) | 0% | 66.1 | 107,875 | Common Stock |
| Miriam Provost | VP, Global Regulatory Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2023 | 3,597 | 7,813 | - | - | Stock Option (Right to Buy) | |
| Miriam Provost | VP, Global Regulatory Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 13 Dec 2023 | 415 | 24,026 (0%) | 0% | 16.1 | 6,698 | Common Stock |
| Hassanein Waleed | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 74.61 per share. | 01 Dec 2023 | 4,475 | 506,791 (2%) | 0% | 74.6 | 333,880 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 75.28 per share. | 01 Dec 2023 | 100 | 506,691 (2%) | 0% | 75.3 | 7,528 | Common Stock |
| Hassanein Waleed | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 74.06 per share. | 01 Dec 2023 | 2,925 | 511,266 (2%) | 0% | 74.1 | 216,626 | Common Stock |
| David Weill | Director | Purchase of securities on an exchange or from another person at price $ 62.00 per share. | 29 Aug 2023 | 2,500 | 13,693 (0%) | 0% | 62 | 155,000 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 93.77 per share. | 01 Aug 2023 | 2,183 | 536,691 (2%) | 0% | 93.8 | 204,700 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 91.91 per share. | 01 Aug 2023 | 727 | 543,464 (2%) | 0% | 91.9 | 66,819 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 92.90 per share. | 01 Aug 2023 | 4,590 | 538,874 (2%) | 0% | 92.9 | 426,411 | Common Stock |
| Anil P. Ranganath | See remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2023 | 9,512 | 9,512 (0%) | 0% | 0 | Common Stock | |
| Anil P. Ranganath | See remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2023 | 14,709 | 14,709 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 18 Jul 2023 | 3,539 | 17,914 (0%) | 0% | 16.1 | 57,119 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.46 per share. | 18 Jul 2023 | 1,461 | 19,375 (0%) | 0% | 38.5 | 56,190 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 95.37 per share. | 18 Jul 2023 | 5,000 | 14,375 (0%) | 0% | 95.4 | 476,850 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jul 2023 | 1,461 | 68,539 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jul 2023 | 3,539 | 17,710 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.05 per share. | 13 Jul 2023 | 2,974 | 14,375 (0%) | 0% | 90.1 | 267,809 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jul 2023 | 2,974 | 21,249 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.02 per share. | 13 Jul 2023 | 2,225 | 14,776 (0%) | 0% | 90.0 | 200,295 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 13 Jul 2023 | 2,974 | 17,349 (0%) | 0% | 16.1 | 48,000 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 81.77 per share. | 03 Jul 2023 | 2,257 | 549,434 (2%) | 0% | 81.8 | 184,555 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 83.49 per share. | 03 Jul 2023 | 590 | 544,191 (2%) | 0% | 83.5 | 49,259 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 82.74 per share. | 03 Jul 2023 | 4,653 | 544,781 (2%) | 0% | 82.7 | 384,989 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 72.21 per share. | 01 Jun 2023 | 1,954 | 551,691 (2%) | 0% | 72.2 | 141,098 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 71.44 per share. | 01 Jun 2023 | 5,546 | 553,645 (2%) | 0% | 71.4 | 396,206 | Common Stock |
| James R. Tobin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,916 | 1,916 | - | - | Stock Option (Right to Buy) | |
| James R. Tobin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,193 | 1,193 (0%) | 0% | 0 | Common Stock | |
| Merilee Raines | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,193 | 1,193 (0%) | 0% | 0 | Common Stock | |
| Merilee Raines | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,916 | 1,916 | - | - | Stock Option (Right to Buy) | |
| Thomas J. Gunderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,193 | 1,193 (0%) | 0% | 0 | Common Stock | |
| Thomas J. Gunderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,916 | 1,916 | - | - | Stock Option (Right to Buy) | |
| Stephanie Lovell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,916 | 1,916 | - | - | Stock Option (Right to Buy) | |
| Stephanie Lovell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,193 | 1,193 (0%) | 0% | 0 | Common Stock | |
| Edward M. Basile | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,916 | 1,916 | - | - | Stock Option (Right to Buy) | |
| Edward M. Basile | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,193 | 15,507 (0%) | 0% | 0 | Common Stock | |
| David Weill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,193 | 11,193 (0%) | 0% | 0 | Common Stock | |
| David Weill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 1,916 | 1,916 | - | - | Stock Option (Right to Buy) | |
| Edwin M. Kania | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2023 | 1,193 | 257,944 (1%) | 0% | 0 | Common Stock | |
| Edwin M. Kania | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2023 | 1,916 | 1,916 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 78.65 per share. | 01 May 2023 | 1,759 | 559,526 (2%) | 0% | 78.6 | 138,345 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 80.12 per share. | 01 May 2023 | 335 | 559,191 (2%) | 0% | 80.1 | 26,840 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 77.84 per share. | 01 May 2023 | 5,406 | 561,285 (2%) | 0% | 77.8 | 420,803 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2023 | 5,000 | 10,728 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 79.05 per share. | 01 May 2023 | 5,000 | 18,789 (0%) | 0% | 79.1 | 395,250 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 01 May 2023 | 5,000 | 23,789 (0%) | 0% | 16.1 | 80,700 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 21 Apr 2023 | 10,000 | 24,375 (0%) | 0% | 16.1 | 161,400 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Apr 2023 | 2,026 | 24,223 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Apr 2023 | 10,000 | 26,249 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.04 per share. | 21 Apr 2023 | 2,775 | 17,001 (0%) | 0% | 90.0 | 249,861 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 90.02 per share. | 21 Apr 2023 | 2,026 | 14,375 (0%) | 0% | 90.0 | 182,381 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 86.09 per share. | 21 Apr 2023 | 1,300 | 16,401 (0%) | 0% | 86.1 | 111,917 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 85.44 per share. | 21 Apr 2023 | 8,700 | 17,701 (0%) | 0% | 85.4 | 743,328 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 21 Apr 2023 | 2,026 | 26,401 (0%) | 0% | 16.1 | 32,700 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 75.14 per share. | 03 Apr 2023 | 3,577 | 567,255 (2%) | 0% | 75.1 | 268,776 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 75.73 per share. | 03 Apr 2023 | 564 | 566,691 (2%) | 0% | 75.7 | 42,712 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 74.34 per share. | 03 Apr 2023 | 3,359 | 570,832 (2%) | 0% | 74.3 | 249,708 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 193,074 | 1 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.21 per share. | 10 Mar 2023 | 193,074 | 574,191 (2%) | 0% | 2.2 | 426,694 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 81.01 per share. | 01 Mar 2023 | 4,900 | 381,117 (1%) | 0% | 81.0 | 396,949 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 80.17 per share. | 01 Mar 2023 | 2,600 | 386,017 (1%) | 0% | 80.2 | 208,442 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 79.51 per share. | 01 Mar 2023 | 5,000 | 18,789 (0%) | 0% | 79.5 | 397,550 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2023 | 5,000 | 15,728 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 01 Mar 2023 | 5,000 | 23,789 (0%) | 0% | 16.1 | 80,700 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 80.10 per share. | 01 Mar 2023 | 3,500 | 14,314 (0%) | 0% | 80.1 | 280,350 | Common Stock |
| Edwin M. Kania | Director | Other type of transaction at price $ 79.76 per share. | 28 Feb 2023 | 145,601 | 159,875 (0%) | 0% | 79.8 | 11,613,136 | Common Stock |
| Edwin M. Kania | Director | Other type of transaction at price $ 79.76 per share. | 28 Feb 2023 | 96,876 | 256,751 (1%) | 0% | 79.8 | 7,726,830 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2023 | 10,000 | 36,249 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 28 Feb 2023 | 10,000 | 24,375 (0%) | 0% | 16.1 | 161,400 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 80.15 per share. | 28 Feb 2023 | 10,000 | 14,375 (0%) | 0% | 80.2 | 801,500 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 80.06 per share. | 28 Feb 2023 | 5,000 | 19,776 (0%) | 0% | 80.1 | 400,300 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 76.20 per share. | 27 Feb 2023 | 1,500 | 21,314 (0%) | 0% | 76.2 | 114,300 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 78.17 per share. | 27 Feb 2023 | 1,500 | 19,814 (0%) | 0% | 78.2 | 117,255 | Common Stock |
| Edward M. Basile | Director | Sale of securities on an exchange or to another person at price $ 79.38 per share. | 27 Feb 2023 | 2,000 | 17,814 (0%) | 0% | 79.4 | 158,760 | Common Stock |
| David Weill | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.20 per share. | 27 Feb 2023 | 5,934 | 15,934 (0%) | 0% | 14.2 | 84,263 | Common Stock |
| David Weill | Director | Sale of securities on an exchange or to another person at price $ 77.64 per share. | 27 Feb 2023 | 964 | 14,970 (0%) | 0% | 77.6 | 74,845 | Common Stock |
| David Weill | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2023 | 5,934 | 10,000 | - | - | Stock Option (Right to Buy) | |
| David Weill | Director | Sale of securities on an exchange or to another person at price $ 76.51 per share. | 27 Feb 2023 | 4,970 | 10,000 (0%) | 0% | 76.5 | 380,255 | Common Stock |
| James R. Tobin | Director | Sale of securities on an exchange or to another person at price $ 75.13 per share. | 23 Feb 2023 | 10,000 | 243,591 (1%) | 0% | 75.1 | 751,300 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 70.31 per share. | 23 Feb 2023 | 6,200 | 420,244 (1%) | 0% | 70.3 | 435,922 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 73.43 per share. | 23 Feb 2023 | 3,577 | 411,860 (1%) | 0% | 73.4 | 262,659 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 74.52 per share. | 23 Feb 2023 | 3,243 | 408,617 (1%) | 0% | 74.5 | 241,668 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 75.15 per share. | 23 Feb 2023 | 20,000 | 388,617 (1%) | 0% | 75.2 | 1,503,000 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 71.32 per share. | 23 Feb 2023 | 4,807 | 415,437 (1%) | 0% | 71.3 | 342,835 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 75.15 per share. | 23 Feb 2023 | 20,000 | 14,375 (0%) | 0% | 75.2 | 1,503,000 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 23 Feb 2023 | 32,179 | 46,554 (0%) | 0% | 16 | 514,864 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 23 Feb 2023 | 3,751 | 50,305 (0%) | 0% | 16.1 | 60,541 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 70.18 per share. | 23 Feb 2023 | 6,319 | 43,986 (0%) | 0% | 70.2 | 443,467 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 71.46 per share. | 23 Feb 2023 | 1,763 | 42,223 (0%) | 0% | 71.5 | 125,984 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 72.02 per share. | 23 Feb 2023 | 6,218 | 36,005 (0%) | 0% | 72.0 | 447,820 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 73.55 per share. | 23 Feb 2023 | 777 | 35,228 (0%) | 0% | 73.5 | 57,148 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 74.67 per share. | 23 Feb 2023 | 853 | 34,375 (0%) | 0% | 74.7 | 63,694 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Feb 2023 | 32,179 | 8,036 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Feb 2023 | 3,751 | 46,249 | - | - | Stock Option (Right to Buy) | |
| Waleed Hassanein | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 37,332 | 426,444 (2%) | 0% | 0 | Common Stock | |
| Waleed Hassanein | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 57,165 | 57,165 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 13,075 | 18,789 (0%) | 0% | 0 | Common Stock | |
| Stephen Gordon | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 20,022 | 20,022 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 13,075 | 14,375 (0%) | 0% | 0 | Common Stock | |
| Tamer Khayal | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 20,022 | 20,022 | - | - | Stock Option (Right to Buy) | |
| Miriam Provost | VP, Global Regulatory Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 5,685 | 20,839 (0%) | 0% | 0 | Common Stock | |
| Miriam Provost | VP, Global Regulatory Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 8,705 | 8,705 | - | - | Stock Option (Right to Buy) | |
| Laura Damme | VP, Clinical Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 5,685 | 5,685 (0%) | 0% | 0 | Common Stock | |
| Laura Damme | VP, Clinical Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 8,705 | 8,705 | - | - | Stock Option (Right to Buy) | |
| Nicholas Corcoran | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 19,732 | 19,732 | - | - | Stock Option (Right to Buy) | |
| Nicholas Corcoran | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2023 | 12,886 | 12,886 (0%) | 0% | 0 | Common Stock | |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 70.08 per share. | 14 Feb 2023 | 2,173 | 389,112 (1%) | 0% | 70.1 | 152,284 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2023 | 4,070 | 40,215 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 70.15 per share. | 14 Feb 2023 | 4,070 | 1,300 (0%) | 0% | 70.2 | 285,511 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 14 Feb 2023 | 4,070 | 5,370 (0%) | 0% | 16 | 65,120 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 64.21 per share. | 01 Feb 2023 | 7,500 | 391,285 (1%) | 0% | 64.2 | 481,575 | Common Stock |
| John Carey | VP of Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.47 per share. | 01 Feb 2023 | 47 | 15,530 (0%) | 0% | 38.5 | 1,808 | Common Stock |
| John Carey | VP of Operations | Sale of securities on an exchange or to another person at price $ 62.52 per share. | 01 Feb 2023 | 379 | 14,569 (0%) | 0% | 62.5 | 23,695 | Common Stock |
| John Carey | VP of Operations | Sale of securities on an exchange or to another person at price $ 62.00 per share. | 01 Feb 2023 | 582 | 14,948 (0%) | 0% | 62 | 36,084 | Common Stock |
| John Carey | VP of Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 01 Feb 2023 | 1,363 | 15,483 (0%) | 0% | 16.1 | 21,999 | Common Stock |
| John Carey | VP of Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2023 | 47 | 13,543 | - | - | Stock Option (Right to Buy) | |
| John Carey | VP of Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2023 | 1,363 | 4,887 | - | - | Stock Option (Right to Buy) | |
| John Carey | VP of Operations | Sale of securities on an exchange or to another person at price $ 65.81 per share. | 01 Feb 2023 | 214 | 14,120 (0%) | 0% | 65.8 | 14,083 | Common Stock |
| John Carey | VP of Operations | Sale of securities on an exchange or to another person at price $ 64.88 per share. | 01 Feb 2023 | 139 | 14,334 (0%) | 0% | 64.9 | 9,018 | Common Stock |
| John Carey | VP of Operations | Sale of securities on an exchange or to another person at price $ 64.04 per share. | 01 Feb 2023 | 96 | 14,473 (0%) | 0% | 64.0 | 6,148 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2023 | 5,000 | 20,728 | - | - | Stock Option (Right to Buy) | |
| Stephen Gordon | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 62.64 per share. | 01 Feb 2023 | 5,000 | 5,714 (0%) | 0% | 62.6 | 313,200 | Common Stock |
| Stephen Gordon | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.14 per share. | 01 Feb 2023 | 5,000 | 10,714 (0%) | 0% | 16.1 | 80,700 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 66.12 per share. | 23 Jan 2023 | 900 | 398,785 (1%) | 0% | 66.1 | 59,508 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 65.36 per share. | 23 Jan 2023 | 11,462 | 399,685 (1%) | 0% | 65.4 | 749,156 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2023 | 3,142 | 44,285 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 65.07 per share. | 23 Jan 2023 | 3,142 | 1,300 (0%) | 0% | 65.1 | 204,450 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 23 Jan 2023 | 3,142 | 4,442 (0%) | 0% | 16 | 50,272 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 65.09 per share. | 18 Jan 2023 | 1,306 | 417,479 (1%) | 0% | 65.1 | 85,008 | Common Stock |
| Waleed Hassanein | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 65.19 per share. | 18 Jan 2023 | 6,332 | 411,147 (1%) | 0% | 65.2 | 412,783 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jan 2023 | 1,300 | 52,985 | - | - | Stock Option (Right to Buy) | |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 65.21 per share. | 18 Jan 2023 | 5,558 | 1,300 (0%) | 0% | 65.2 | 362,437 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 18 Jan 2023 | 5,558 | 6,858 (0%) | 0% | 16 | 88,928 | Common Stock |
| Tamer Khayal | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 65.11 per share. | 18 Jan 2023 | 1,300 | 1,300 (0%) | 0% | 65.1 | 84,643 | Common Stock |