908.7K XNAS Volume
XNAS 19 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 55.12 per share. | 03 Mar 2025 | 3,598 | 170,112 (0%) | 0% | 55.1 | 198,331 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 54.26 per share. | 03 Mar 2025 | 12,078 | 173,710 (0%) | 0% | 54.3 | 655,331 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 53.12 per share. | 03 Mar 2025 | 3,924 | 185,788 (0%) | 0% | 53.1 | 208,450 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 56.20 per share. | 03 Mar 2025 | 400 | 169,712 (0%) | 0% | 56.2 | 22,481 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 54.24 per share. | 27 Feb 2025 | 23,600 | 968,469 (2%) | 0% | 54.2 | 1,280,135 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 53.41 per share. | 27 Feb 2025 | 30,756 | 1,003,869 (2%) | 0% | 53.4 | 1,642,678 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 52.97 per share. | 27 Feb 2025 | 11,800 | 992,069 (2%) | 0% | 53.0 | 625,017 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 56.89 per share. | 27 Feb 2025 | 600 | 954,869 (2%) | 0% | 56.9 | 34,134 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 56.13 per share. | 27 Feb 2025 | 1,400 | 955,469 (2%) | 0% | 56.1 | 78,588 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 55.15 per share. | 27 Feb 2025 | 11,600 | 956,869 (2%) | 0% | 55.2 | 639,783 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.10 per share. | 20 Feb 2025 | 24,260 | 1,039,693 (2%) | 0% | 60.1 | 1,458,053 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 61.24 per share. | 20 Feb 2025 | 5,068 | 1,034,625 (2%) | 0% | 61.2 | 310,348 | Common Stock |
| Daniel S. Lynch | Director | Sale of securities on an exchange or to another person at price $ 61.24 per share. | 20 Feb 2025 | 3,582 | 82,944 (0%) | 0% | 61.2 | 219,349 | Common Stock |
| Daniel S. Lynch | Director | Sale of securities on an exchange or to another person at price $ 60.14 per share. | 20 Feb 2025 | 44,018 | 86,526 (0%) | 0% | 60.1 | 2,647,185 | Common Stock |
| Bhavesh Ashar | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 61.19 per share. | 20 Feb 2025 | 1,016 | 62,053 (0%) | 0% | 61.2 | 62,168 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 59.92 per share. | 14 Feb 2025 | 10,672 | 1,063,953 (2%) | 0% | 59.9 | 639,490 | Common Stock |
| Daniel S. Lynch | Director | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 14 Feb 2025 | 400 | 130,544 (0%) | 0% | 60 | 24,000 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 59.28 per share. | 12 Feb 2025 | 13,186 | 1,074,625 (2%) | 0% | 59.3 | 781,666 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2025 | 85,309 | 1,087,811 (2%) | 0% | 0 | Common Stock | |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 53.30 per share. | 10 Feb 2025 | 48,000 | 1,002,502 (2%) | 0% | 53.3 | 2,558,237 | Common Stock |
| Daniel S. Lynch | Director | Sale of securities on an exchange or to another person at price $ 55.51 per share. | 10 Feb 2025 | 65,600 | 130,944 (0%) | 0% | 55.5 | 3,641,751 | Common Stock |
| Daniel S. Lynch | Director | Sale of securities on an exchange or to another person at price $ 54.88 per share. | 10 Feb 2025 | 39,634 | 196,544 (0%) | 0% | 54.9 | 2,175,047 | Common Stock |
| Daniel S. Lynch | Director | Sale of securities on an exchange or to another person at price $ 53.23 per share. | 10 Feb 2025 | 69,766 | 236,178 (0%) | 0% | 53.2 | 3,713,553 | Common Stock |
| Julie Hambleton | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.27 per share. | 10 Feb 2025 | 13,774 | 17,869 (0%) | 0% | 32.3 | 444,487 | Common Stock |
| Julie Hambleton | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Feb 2025 | 13,774 | 0 | - | - | Stock Option (Right to Buy) | |
| Julie Hambleton | Director | Sale of securities on an exchange or to another person at price $ 53.01 per share. | 10 Feb 2025 | 13,774 | 4,095 (0%) | 0% | 53.0 | 730,207 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 53.13 per share. | 10 Feb 2025 | 30,000 | 189,712 (0%) | 0% | 53.1 | 1,593,795 | Common Stock |
| Daniel Pichl | Chief People Officer | Sale of securities on an exchange or to another person at price $ 57.15 per share. | 10 Feb 2025 | 7,000 | 50,762 (0%) | 0% | 57.2 | 400,072 | Common Stock |
| Daniel Pichl | Chief People Officer | Sale of securities on an exchange or to another person at price $ 54.25 per share. | 10 Feb 2025 | 9,000 | 57,762 (0%) | 0% | 54.3 | 488,260 | Common Stock |
| Daniel Pichl | Chief People Officer | Sale of securities on an exchange or to another person at price $ 53.02 per share. | 10 Feb 2025 | 13,750 | 66,762 (0%) | 0% | 53.0 | 728,998 | Common Stock |
| Daniel Pichl | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.64 per share. | 10 Feb 2025 | 16,000 | 80,512 (0%) | 0% | 27.6 | 442,240 | Common Stock |
| Daniel Pichl | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.64 per share. | 10 Feb 2025 | 13,750 | 64,512 (0%) | 0% | 27.6 | 380,050 | Common Stock |
| Daniel Pichl | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Feb 2025 | 13,750 | 31,250 | - | - | Stock Option (Right to Buy) | |
| Daniel Pichl | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Feb 2025 | 16,000 | 32,750 | - | - | Stock Option (Right to Buy) | |
| Herschel S. Weinstein | General Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 12,126 | 55,239 (0%) | 0% | 0 | Common Stock | |
| Herschel S. Weinstein | General Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 35,431 | 35,431 | - | - | Stock Option (Right to Buy) | |
| Francis I. Perier | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 11,779 | 60,889 (0%) | 0% | 0 | Common Stock | |
| Francis I. Perier | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 34,419 | 34,419 | - | - | Stock Option (Right to Buy) | |
| Saqib Islam | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 109,329 | 109,329 | - | - | Stock Option (Right to Buy) | |
| Saqib Islam | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 74,834 | 1,050,502 (2%) | 0% | 0 | Common Stock | |
| P. | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 20,246 | 20,246 | - | - | Stock Option (Right to Buy) | |
| P. | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 6,929 | 30,623 (0%) | 0% | 0 | Common Stock | |
| Badreddin Edris | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 27,023 | 219,712 (0%) | 0% | 0 | Common Stock | |
| Badreddin Edris | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 78,960 | 78,960 | - | - | Stock Option (Right to Buy) | |
| Daniel Pichl | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 37,455 | 37,455 | - | - | Stock Option (Right to Buy) | |
| Daniel Pichl | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 12,819 | 50,762 (0%) | 0% | 0 | Common Stock | |
| Bhavesh Ashar | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 50,615 | 50,615 | - | - | Stock Option (Right to Buy) | |
| Bhavesh Ashar | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 17,323 | 63,069 (0%) | 0% | 0 | Common Stock | |
| James Cassidy | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 17,323 | 81,731 (0%) | 0% | 0 | Common Stock | |
| James Cassidy | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 50,615 | 50,615 | - | - | Stock Option (Right to Buy) | |
| Tai-An Lin | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 20,246 | 20,246 | - | - | Stock Option (Right to Buy) | |
| Tai-An Lin | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2025 | 6,929 | 33,039 (0%) | 0% | 0 | Common Stock | |
| Herschel S. Weinstein | General Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 3,575 | 48,664 (0%) | 0% | 38.2 | 136,529 | Common Stock |
| Herschel S. Weinstein | General Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 3,272 | 45,392 (0%) | 0% | 38.2 | 124,958 | Common Stock |
| Herschel S. Weinstein | General Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.86 per share. | 04 Jan 2025 | 2,279 | 43,113 (0%) | 0% | 38.9 | 88,562 | Common Stock |
| Francis I. Perier | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.86 per share. | 04 Jan 2025 | 3,283 | 49,110 (0%) | 0% | 38.9 | 127,577 | Common Stock |
| Francis I. Perier | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 3,582 | 55,671 (0%) | 0% | 38.2 | 136,797 | Common Stock |
| Francis I. Perier | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 3,278 | 52,393 (0%) | 0% | 38.2 | 125,187 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 13,469 | 1,000,899 (2%) | 0% | 38.2 | 514,381 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 12,872 | 988,027 (2%) | 0% | 38.2 | 491,582 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.86 per share. | 04 Jan 2025 | 12,359 | 975,668 (2%) | 0% | 38.9 | 480,271 | Common Stock |
| P. | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.86 per share. | 04 Jan 2025 | 1,009 | 23,694 (0%) | 0% | 38.9 | 39,210 | Common Stock |
| P. | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 1,636 | 24,703 (0%) | 0% | 38.2 | 62,479 | Common Stock |
| P. | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 2,388 | 26,339 (0%) | 0% | 38.2 | 91,198 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 5,561 | 197,105 (0%) | 0% | 38.2 | 212,375 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 6,934 | 202,666 (0%) | 0% | 38.2 | 264,809 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.86 per share. | 04 Jan 2025 | 4,416 | 192,689 (0%) | 0% | 38.9 | 171,606 | Common Stock |
| Daniel Pichl | Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.86 per share. | 04 Jan 2025 | 1,759 | 37,943 (0%) | 0% | 38.9 | 68,355 | Common Stock |
| Daniel Pichl | Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 2,988 | 42,224 (0%) | 0% | 38.2 | 114,112 | Common Stock |
| Daniel Pichl | Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 2,522 | 39,702 (0%) | 0% | 38.2 | 96,315 | Common Stock |
| Bhavesh Ashar | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.86 per share. | 04 Jan 2025 | 2,284 | 45,746 (0%) | 0% | 38.9 | 88,756 | Common Stock |
| Bhavesh Ashar | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 4,475 | 51,855 (0%) | 0% | 38.2 | 170,900 | Common Stock |
| Bhavesh Ashar | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 3,825 | 48,030 (0%) | 0% | 38.2 | 146,077 | Common Stock |
| James Cassidy | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 4,325 | 69,531 (0%) | 0% | 38.2 | 165,172 | Common Stock |
| James Cassidy | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.86 per share. | 04 Jan 2025 | 1,658 | 64,408 (0%) | 0% | 38.9 | 64,430 | Common Stock |
| James Cassidy | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 3,465 | 66,066 (0%) | 0% | 38.2 | 132,328 | Common Stock |
| Tai-An Lin | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.19 per share. | 04 Jan 2025 | 855 | 26,110 (0%) | 0% | 38.2 | 32,652 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 41.78 per share. | 03 Dec 2024 | 11,966 | 217,634 (0%) | 0% | 41.8 | 499,942 | Common Stock |
| Edris Badreddin | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 42.24 per share. | 03 Dec 2024 | 8,034 | 209,600 (0%) | 0% | 42.2 | 339,394 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.85 per share. | 02 Dec 2024 | 3,989 | 1,014,368 (2%) | 0% | 41.8 | 166,936 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.33 per share. | 02 Dec 2024 | 45,011 | 1,018,357 (2%) | 0% | 41.3 | 1,860,422 | Common Stock |
| Tai-An Lin | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.83 per share. | 02 Oct 2024 | 2,324 | 26,965 (0%) | 0% | 32.8 | 76,297 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.10 per share. | 03 Sep 2024 | 32,400 | 1,079,968 (2%) | 0% | 40.1 | 1,299,224 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 42.07 per share. | 03 Sep 2024 | 6,692 | 1,063,368 (2%) | 0% | 42.1 | 281,550 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.10 per share. | 03 Sep 2024 | 9,908 | 1,070,060 (2%) | 0% | 41.1 | 407,259 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 41.12 per share. | 03 Sep 2024 | 4,620 | 232,680 (0%) | 0% | 41.1 | 189,955 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.11 per share. | 03 Sep 2024 | 12,300 | 237,300 (0%) | 0% | 40.1 | 493,408 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 42.08 per share. | 03 Sep 2024 | 3,080 | 229,600 (0%) | 0% | 42.1 | 129,591 | Common Stock |
| James Cassidy | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.71 per share. | 30 Aug 2024 | 1,969 | 73,856 (0%) | 0% | 41.7 | 82,127 | Common Stock |
| Martin W. Mackay | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2024 | 29,445 | 29,445 | - | - | Stock Option (Right to Buy) | |
| Martin W. Mackay | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2024 | 9,963 | 9,963 (0%) | 0% | 0 | Common Stock | |
| James Cassidy | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.53 per share. | 01 Jul 2024 | 591 | 75,825 (0%) | 0% | 38.5 | 22,771 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 39.40 per share. | 03 Jun 2024 | 33,240 | 1,128,128 (2%) | 0% | 39.4 | 1,309,666 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 42.09 per share. | 03 Jun 2024 | 400 | 1,112,368 (2%) | 0% | 42.1 | 16,837 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 41.40 per share. | 03 Jun 2024 | 6,600 | 1,112,768 (2%) | 0% | 41.4 | 273,247 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.57 per share. | 03 Jun 2024 | 8,760 | 1,119,368 (2%) | 0% | 40.6 | 355,363 | Common Stock |
| Julie Hambleton | Director | Sale of securities on an exchange or to another person at price $ 39.41 per share. | 03 Jun 2024 | 2,946 | 5,797 (0%) | 0% | 39.4 | 116,111 | Common Stock |
| Julie Hambleton | Director | Sale of securities on an exchange or to another person at price $ 40.57 per share. | 03 Jun 2024 | 751 | 5,046 (0%) | 0% | 40.6 | 30,465 | Common Stock |
| Julie Hambleton | Director | Sale of securities on an exchange or to another person at price $ 41.49 per share. | 03 Jun 2024 | 931 | 4,115 (0%) | 0% | 41.5 | 38,629 | Common Stock |
| Julie Hambleton | Director | Sale of securities on an exchange or to another person at price $ 42.10 per share. | 03 Jun 2024 | 20 | 4,095 (0%) | 0% | 42.1 | 842 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.62 per share. | 03 Jun 2024 | 4,192 | 253,636 (0%) | 0% | 40.6 | 170,287 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 42.04 per share. | 03 Jun 2024 | 385 | 249,600 (0%) | 0% | 42.0 | 16,184 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 41.38 per share. | 03 Jun 2024 | 3,651 | 249,985 (0%) | 0% | 41.4 | 151,066 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 39.40 per share. | 03 Jun 2024 | 11,772 | 257,828 (0%) | 0% | 39.4 | 463,834 | Common Stock |
| Freda C. Lewis-Hall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 12,216 | 12,216 | - | - | Stock Option (Right to Buy) | |
| Freda C. Lewis-Hall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 4,095 | 14,667 (0%) | 0% | 0 | Common Stock | |
| Alan Fuhrman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 4,095 | 14,667 (0%) | 0% | 0 | Common Stock | |
| Alan Fuhrman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 12,216 | 12,216 | - | - | Stock Option (Right to Buy) | |
| Carlos Alban | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 12,216 | 12,216 | - | - | Stock Option (Right to Buy) | |
| Carlos Alban | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 4,095 | 18,801 (0%) | 0% | 0 | Common Stock | |
| Daniel S. Lynch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 4,095 | 305,944 (0%) | 0% | 0 | Common Stock | |
| Daniel S. Lynch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 12,216 | 12,216 | - | - | Stock Option (Right to Buy) | |
| Julie Hambleton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 4,095 | 8,743 (0%) | 0% | 0 | Common Stock | |
| Julie Hambleton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 12,216 | 12,216 | - | - | Stock Option (Right to Buy) | |
| Bhavesh Ashar | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 47.62 per share. | 01 Apr 2024 | 1,824 | 56,330 (0%) | 0% | 47.6 | 86,859 | Common Stock |
| Daniel Pichl | Chief People Officer | Sale of securities on an exchange or to another person at price $ 50.10 per share. | 16 Feb 2024 | 15,000 | 45,212 (0%) | 0% | 50.1 | 751,550 | Common Stock |
| Daniel Pichl | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2024 | 15,000 | 45,000 | - | - | Stock Option (Right to Buy) | |
| Daniel Pichl | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.64 per share. | 16 Feb 2024 | 15,000 | 60,212 (0%) | 0% | 27.6 | 414,600 | Common Stock |
| Bhavesh Ashar | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 43.75 per share. | 02 Feb 2024 | 1,089 | 65,121 (0%) | 0% | 43.7 | 47,640 | Common Stock |
| Pichl Daniel | Chief People Officer | Sale of securities on an exchange or to another person at price $ 45.95 per share. | 02 Feb 2024 | 1,997 | 45,955 (0%) | 0% | 45.9 | 91,756 | Common Stock |
| Pichl Daniel | Chief People Officer | Sale of securities on an exchange or to another person at price $ 46.44 per share. | 02 Feb 2024 | 743 | 45,212 (0%) | 0% | 46.4 | 34,507 | Common Stock |
| Daniel Pichl | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2024 | 16,250 | 48,750 | - | - | Stock Option (Right to Buy) | |
| Bhavesh Ashar | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 44.31 per share. | 02 Feb 2024 | 1,667 | 63,454 (0%) | 0% | 44.3 | 73,868 | Common Stock |
| Daniel Pichl | Chief People Officer | Sale of securities on an exchange or to another person at price $ 43.81 per share. | 02 Feb 2024 | 9,266 | 62,127 (0%) | 0% | 43.8 | 405,942 | Common Stock |
| Daniel Pichl | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.64 per share. | 02 Feb 2024 | 16,250 | 71,393 (0%) | 0% | 27.6 | 449,150 | Common Stock |
| Daniel Pichl | Chief People Officer | Sale of securities on an exchange or to another person at price $ 44.31 per share. | 02 Feb 2024 | 14,175 | 47,952 (0%) | 0% | 44.3 | 628,157 | Common Stock |
| Bhavesh Ashar | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 46.38 per share. | 02 Feb 2024 | 88 | 62,988 (0%) | 0% | 46.4 | 4,081 | Common Stock |
| Ashar Bhavesh | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 49.32 per share. | 02 Feb 2024 | 4,834 | 58,154 (0%) | 0% | 49.3 | 238,435 | Common Stock |
| Ashar Bhavesh | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 46.00 per share. | 02 Feb 2024 | 378 | 63,076 (0%) | 0% | 46.0 | 17,387 | Common Stock |
| James Cassidy | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| Michael Nofi | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 14,104 | 30,959 (0%) | 0% | 0 | Common Stock | |
| Weinstein Herschel S. | General Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.53 per share. | 04 Jan 2024 | 2,423 | 52,239 (0%) | 0% | 41.5 | 100,627 | Common Stock |
| Ashar Bhavesh | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 75,000 | 75,000 | - | - | Stock Option (Right to Buy) | |
| Islam Saqib | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 88,000 | 287,053 (0%) | 0% | 0 | Common Stock | |
| Tai-An Lin | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 5,289 | 29,289 (0%) | 0% | 0 | Common Stock | |
| Cassidy James | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.96 per share. | 04 Jan 2024 | 2,357 | 77,509 (0%) | 0% | 38.0 | 89,472 | Common Stock |
| Herschel S. Weinstein | General Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.96 per share. | 04 Jan 2024 | 2,324 | 54,662 (0%) | 0% | 38.0 | 88,219 | Common Stock |
| Bhavesh Ashar | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.53 per share. | 04 Jan 2024 | 1,449 | 66,210 (0%) | 0% | 41.5 | 60,177 | Common Stock |
| Michael Nofi | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| S. Weinstein Herschel | General Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 21,156 | 56,986 (0%) | 0% | 0 | Common Stock | |
| James Cassidy | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.53 per share. | 04 Jan 2024 | 1,093 | 76,416 (0%) | 0% | 41.5 | 45,392 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.53 per share. | 04 Jan 2024 | 5,466 | 269,600 (0%) | 0% | 41.5 | 227,003 | Common Stock |
| Smith L. Mary | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.53 per share. | 04 Jan 2024 | 3,535 | 233,363 (0%) | 0% | 41.5 | 146,809 | Common Stock |
| Islam Saqib | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.96 per share. | 04 Jan 2024 | 12,885 | 274,168 (0%) | 0% | 38.0 | 489,115 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.53 per share. | 04 Jan 2024 | 17,904 | 256,264 (0%) | 0% | 41.5 | 743,553 | Common Stock |
| Francis Perier I. | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.96 per share. | 04 Jan 2024 | 2,151 | 62,468 (0%) | 0% | 38.0 | 81,652 | Common Stock |
| S. Herschel Weinstein | General Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| I. Francis Perier | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 21,156 | 64,619 (0%) | 0% | 0 | Common Stock | |
| Pichl Daniel | Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.96 per share. | 04 Jan 2024 | 1,574 | 56,548 (0%) | 0% | 38.0 | 59,749 | Common Stock |
| James Cassidy | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 28,208 | 79,866 (0%) | 0% | 0 | Common Stock | |
| Islam Saqib | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 250,000 | 250,000 | - | - | Stock Option (Right to Buy) | |
| Pichl Daniel | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 22,919 | 58,122 (0%) | 0% | 0 | Common Stock | |
| L. Mary Smith | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 21,156 | 239,095 (0%) | 0% | 0 | Common Stock | |
| Francis I. Perier | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.53 per share. | 04 Jan 2024 | 3,215 | 59,253 (0%) | 0% | 41.5 | 133,519 | Common Stock |
| Nofi Michael | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.53 per share. | 04 Jan 2024 | 1,063 | 28,727 (0%) | 0% | 41.5 | 44,146 | Common Stock |
| L. Mary Smith | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Badreddin Edris | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 42,312 | 279,535 (0%) | 0% | 0 | Common Stock | |
| Daniel Pichl | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 65,000 | 65,000 | - | - | Stock Option (Right to Buy) | |
| Badreddin Edris | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.96 per share. | 04 Jan 2024 | 4,469 | 275,066 (0%) | 0% | 38.0 | 169,643 | Common Stock |
| Ashar Bhavesh | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 26,445 | 70,166 (0%) | 0% | 0 | Common Stock | |
| Badreddin Edris | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 120,000 | 120,000 | - | - | Stock Option (Right to Buy) | |
| I. Francis Perier | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Smith L. Mary | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.96 per share. | 04 Jan 2024 | 2,197 | 236,898 (0%) | 0% | 38.0 | 83,398 | Common Stock |
| Daniel Pichl | Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.53 per share. | 04 Jan 2024 | 1,405 | 55,143 (0%) | 0% | 41.5 | 58,350 | Common Stock |
| Nofi Michael | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.96 per share. | 04 Jan 2024 | 1,169 | 29,790 (0%) | 0% | 38.0 | 44,375 | Common Stock |
| Bhavesh Ashar | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.96 per share. | 04 Jan 2024 | 2,507 | 67,659 (0%) | 0% | 38.0 | 95,166 | Common Stock |
| Lin Tai-An | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Julie Hambleton | Director | Sale of securities on an exchange or to another person at price $ 29.31 per share. | 19 Jul 2023 | 2,418 | 4,648 (0%) | 0% | 29.3 | 70,876 | Common Stock |
| L. Mary Smith | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 5,720 | 217,939 (0%) | 0% | - | Common Stock | |
| James Cassidy | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 5,720 | 52,950 (0%) | 0% | - | Common Stock | |
| Julie Hambleton | Director | Sale of securities on an exchange or to another person at price $ 26.92 per share. | 20 Jun 2023 | 2,400 | 7,066 (0%) | 0% | 26.9 | 64,603 | Common Stock |
| Freda C. Lewis-Hall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 4,648 | 10,572 (0%) | 0% | 0 | Common Stock | |
| Freda C. Lewis-Hall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 13,774 | 13,774 | - | - | Stock Option (Right to Buy) | |
| Alan Fuhrman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 4,648 | 10,572 (0%) | 0% | 0 | Common Stock | |
| Alan Fuhrman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 13,774 | 13,774 | - | - | Stock Option (Right to Buy) | |
| Carlos Alban | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 4,648 | 14,706 (0%) | 0% | 0 | Common Stock | |
| Carlos Alban | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 13,774 | 13,774 | - | - | Stock Option (Right to Buy) | |
| Daniel S. Lynch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 4,648 | 301,849 (0%) | 0% | 0 | Common Stock | |
| Daniel S. Lynch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 13,774 | 13,774 | - | - | Stock Option (Right to Buy) | |
| Julie Hambleton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 13,774 | 13,774 | - | - | Stock Option (Right to Buy) | |
| Julie Hambleton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 4,648 | 9,466 (0%) | 0% | 0 | Common Stock | |
| Jeffrey Schwartz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 13,774 | 13,774 | - | - | Stock Option (Right to Buy) | |
| Jeffrey Schwartz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 4,648 | 10,572 (0%) | 0% | 0 | Common Stock | |
| Bhavesh Ashar | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.25 per share. | 03 Apr 2023 | 1,375 | 43,721 (0%) | 0% | 25.3 | 34,719 | Common Stock |
| Jeffrey Schwartz | Director | Sale of securities on an exchange or to another person at price $ 28.50 per share. | 16 Mar 2023 | 1,750,000 | 3,081,307 (7%) | 4% | 28.5 | 49,875,000 | Common Stock |
| Julie Hambleton | Director | Sale of securities on an exchange or to another person at price $ 31.50 per share. | 15 Mar 2023 | 1,106 | 4,818 (0%) | 0% | 31.5 | 34,841 | Common Stock |
| Daniel Pichl | Chief People Officer | Sale of securities on an exchange or to another person at price $ 31.00 per share. | 26 Jan 2023 | 858 | 35,203 (0%) | 0% | 31 | 26,598 | Common Stock |
| Herschel S. Weinstein | General Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.41 per share. | 07 Jan 2023 | 909 | 35,830 (0%) | 0% | 26.4 | 24,007 | Common Stock |
| Francis I. Perier | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.41 per share. | 07 Jan 2023 | 1,090 | 43,463 (0%) | 0% | 26.4 | 28,787 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.41 per share. | 07 Jan 2023 | 4,097 | 905,104 (2%) | 0% | 26.4 | 108,202 | Common Stock |
| Michael Nofi | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.41 per share. | 07 Jan 2023 | 409 | 16,855 (0%) | 0% | 26.4 | 10,802 | Common Stock |
| L. Mary Smith | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.41 per share. | 07 Jan 2023 | 1,068 | 212,219 (0%) | 0% | 26.4 | 28,206 | Common Stock |
| Daniel Pichl | Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.41 per share. | 07 Jan 2023 | 546 | 36,061 (0%) | 0% | 26.4 | 14,420 | Common Stock |
| Herschel S. Weinstein | General Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 19,425 | 38,521 (0%) | 0% | - | Common Stock | |
| Herschel S. Weinstein | General Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.52 per share. | 05 Jan 2023 | 1,782 | 36,739 (0%) | 0% | 27.5 | 49,041 | Common Stock |
| Herschel S. Weinstein | General Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Herschel S. Weinstein | General Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 65,000 | 65,000 | - | - | Stock Option (Right to Buy) | |
| Francis I. Perier | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 65,000 | 65,000 | - | - | Stock Option (Right to Buy) | |
| Francis I. Perier | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Francis I. Perier | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.52 per share. | 05 Jan 2023 | 2,374 | 44,553 (0%) | 0% | 27.5 | 65,332 | Common Stock |
| Francis I. Perier | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 19,425 | 46,927 (0%) | 0% | - | Common Stock | |
| Saqib Islam | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 84,175 | 917,601 (2%) | 0% | - | Common Stock | |
| Saqib Islam | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.52 per share. | 05 Jan 2023 | 8,400 | 909,201 (2%) | 0% | 27.5 | 231,168 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 260,000 | 260,000 | - | - | Stock Option (Right to Buy) | |
| Michael Nofi | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Michael Nofi | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 9,713 | 18,047 (0%) | 0% | - | Common Stock | |
| Michael Nofi | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.52 per share. | 05 Jan 2023 | 783 | 17,264 (0%) | 0% | 27.5 | 21,548 | Common Stock |
| Michael Nofi | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Badreddin Edris | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 135,000 | 135,000 | - | - | Stock Option (Right to Buy) | |
| Badreddin Edris | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 33,994 | 242,032 (0%) | 0% | - | Common Stock | |
| Badreddin Edris | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.52 per share. | 05 Jan 2023 | 3,326 | 238,706 (0%) | 0% | 27.5 | 91,532 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 105,000 | 105,000 | - | - | Stock Option (Right to Buy) | |
| L. Mary Smith | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 65,000 | 65,000 | - | - | Stock Option (Right to Buy) | |
| L. Mary Smith | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 70,000 | 70,000 | - | - | Stock Option (Right to Buy) | |
| L. Mary Smith | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.52 per share. | 05 Jan 2023 | 2,452 | 213,287 (0%) | 0% | 27.5 | 67,479 | Common Stock |
| L. Mary Smith | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 22,663 | 215,739 (0%) | 0% | - | Common Stock | |
| Daniel Pichl | Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.52 per share. | 05 Jan 2023 | 1,719 | 36,607 (0%) | 0% | 27.5 | 47,307 | Common Stock |
| Daniel Pichl | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 19,425 | 38,326 (0%) | 0% | - | Common Stock | |
| Daniel Pichl | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 65,000 | 65,000 | - | - | Stock Option (Right to Buy) | |
| Daniel Pichl | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Bhavesh Ashar | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.52 per share. | 05 Jan 2023 | 1,665 | 45,096 (0%) | 0% | 27.5 | 45,821 | Common Stock |
| Bhavesh Ashar | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 22,663 | 46,761 (0%) | 0% | - | Common Stock | |
| Bhavesh Ashar | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 70,000 | 70,000 | - | - | Stock Option (Right to Buy) | |
| James Cassidy | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 70,000 | 70,000 | - | - | Stock Option (Right to Buy) | |
| James Cassidy | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.52 per share. | 05 Jan 2023 | 1,263 | 47,230 (0%) | 0% | 27.5 | 34,758 | Common Stock |
| James Cassidy | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 65,000 | 65,000 | - | - | Stock Option (Right to Buy) | |
| James Cassidy | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 22,663 | 48,493 (0%) | 0% | - | Common Stock | |
| L. Mary Smith | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.47 per share. | 18 Jul 2022 | 1,551 | 193,076 (0%) | 0% | 28.5 | 44,157 | Common Stock |
| Michael Burgess | Head of Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.47 per share. | 18 Jul 2022 | 3,103 | 49,584 (0%) | 0% | 28.5 | 88,342 | Common Stock |
| Carlos Alban | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jul 2022 | 10,058 | 10,058 (0%) | 0% | 0 | Common Stock | |
| Carlos Alban | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jul 2022 | 30,160 | 30,160 | - | - | Stock Option (Right to Buy) | |
| L. Mary Smith | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 6,092 | 194,627 (0%) | 0% | 0 | Common Stock | |
| Michael Burgess | Head of Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2022 | 12,185 | 52,687 (0%) | 0% | 0 | Common Stock | |
| Michael Burgess | Head of Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.61 per share. | 01 Jun 2022 | 2,672 | 40,502 (0%) | 0% | 19.6 | 52,398 | Common Stock |
| Freda C. Lewis-Hall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 15,318 | 15,318 | - | - | Stock Option (Right to Buy) | |
| Freda C. Lewis-Hall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 4,818 | 5,924 (0%) | 0% | 0 | Common Stock | |
| Stephen P. Squinto | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 4,818 | 131,652 (0%) | 0% | 0 | Common Stock | |
| Stephen P. Squinto | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 15,318 | 15,318 | - | - | Stock Option (Right to Buy) | |
| Alan Fuhrman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 4,818 | 5,924 (0%) | 0% | 0 | Common Stock | |
| Alan Fuhrman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 15,318 | 15,318 | - | - | Stock Option (Right to Buy) | |
| Daniel S. Lynch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 15,318 | 15,318 | - | - | Stock Option (Right to Buy) | |
| Daniel S. Lynch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 4,818 | 297,201 (0%) | 0% | 0 | Common Stock | |
| Julie Hambleton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 15,318 | 15,318 | - | - | Stock Option (Right to Buy) | |
| Julie Hambleton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 4,818 | 5,924 (0%) | 0% | 0 | Common Stock | |
| Jeffrey Schwartz, | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 15,318 | 15,318 | - | - | Stock Option (Right to Buy) | |
| Jeffrey Schwartz, | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2022 | 4,818 | 5,924 (0%) | 0% | 0 | Common Stock | |
| Bhavesh Ashar | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2022 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Bhavesh Ashar | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.90 per share. | 01 Apr 2022 | 1,464 | 24,098 (0%) | 0% | 56.9 | 83,302 | Common Stock |
| Herschel S. Weinstein | General Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.06 per share. | 07 Jan 2022 | 966 | 19,096 (0%) | 0% | 56.1 | 54,154 | Common Stock |
| Francis I. Perier | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.06 per share. | 07 Jan 2022 | 1,307 | 27,502 (0%) | 0% | 56.1 | 73,270 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.06 per share. | 07 Jan 2022 | 3,996 | 853,592 (1%) | 0% | 56.1 | 224,016 | Common Stock |
| Michael Nofi | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.06 per share. | 07 Jan 2022 | 414 | 8,334 (0%) | 0% | 56.1 | 23,209 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.06 per share. | 07 Jan 2022 | 1,852 | 325,813 (0%) | 0% | 56.1 | 103,823 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.41 per share. | 07 Jan 2022 | 1,483 | 237,223 (0%) | 0% | 26.4 | 39,166 | Common Stock |
| L. Mary Smith | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.06 per share. | 07 Jan 2022 | 1,181 | 188,535 (0%) | 0% | 56.1 | 66,207 | Common Stock |
| Daniel Pichl | Chief People Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.06 per share. | 07 Jan 2022 | 631 | 21,667 (0%) | 0% | 56.1 | 35,374 | Common Stock |
| Herschel S. Weinstein | General Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 40,710 | 40,710 | - | - | Stock Option (Right to Buy) | |
| Herschel S. Weinstein | General Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 13,062 | 20,062 (0%) | 0% | - | Common Stock | |
| Francis I. Perier | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 18,809 | 28,809 (0%) | 0% | - | Common Stock | |
| Francis I. Perier | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 58,622 | 58,622 | - | - | Stock Option (Right to Buy) | |
| Saqib Islam | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 244,258 | 244,258 | - | - | Stock Option (Right to Buy) | |
| Saqib Islam | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 78,370 | 857,588 (1%) | 0% | - | Common Stock | |
| Michael Nofi | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 17,913 | 17,913 | - | - | Stock Option (Right to Buy) | |
| Michael Nofi | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 5,748 | 8,748 (0%) | 0% | - | Common Stock | |
| Badreddin Edris | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 26,124 | 327,665 (0%) | 0% | - | Common Stock | |
| Badreddin Edris | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 81,420 | 81,420 | - | - | Stock Option (Right to Buy) | |
| L. Mary Smith | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 22,205 | 189,716 (0%) | 0% | - | Common Stock | |
| L. Mary Smith | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 69,207 | 69,207 | - | - | Stock Option (Right to Buy) | |
| Michael Burgess | Head of Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 48,852 | 48,852 | - | - | Stock Option (Right to Buy) | |
| Michael Burgess | Head of Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 15,674 | 43,174 (0%) | 0% | - | Common Stock | |
| Daniel Pichl | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 13,062 | 22,298 (0%) | 0% | - | Common Stock | |
| Daniel Pichl | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 40,710 | 40,710 | - | - | Stock Option (Right to Buy) | |
| Bhavesh Ashar | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 40,710 | 40,710 | - | - | Stock Option (Right to Buy) | |
| Bhavesh Ashar | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 13,062 | 25,562 (0%) | 0% | - | Common Stock | |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 58.67 per share. | 20 Oct 2021 | 10,083 | 779,218 (1%) | 0% | 58.7 | 591,527 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 58.81 per share. | 18 Oct 2021 | 14,077 | 769,135 (1%) | 0% | 58.8 | 827,873 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 58.59 per share. | 18 Oct 2021 | 38,340 | 783,212 (1%) | 0% | 58.6 | 2,246,505 | Common Stock |
| L. Mary Smith | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.30 per share. | 13 Oct 2021 | 10,000 | 177,511 (0%) | 0% | 2.3 | 23,000 | Common Stock |
| L. Mary Smith | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2021 | 10,000 | 84,296 | - | - | Stock Option (Right to Buy) | |
| L. Mary Smith | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 55.97 per share. | 13 Oct 2021 | 10,000 | 167,511 (0%) | 0% | 56.0 | 559,675 | Common Stock |
| Daniel Pichl | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2021 | 2,320 | 72,680 | - | - | Stock Option (Right to Buy) | |
| Daniel Pichl | Chief People Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 43.10 per share. | 08 Sep 2021 | 2,320 | 9,236 (0%) | 0% | 43.1 | 99,992 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 77.68 per share. | 19 Jul 2021 | 18,572 | 821,552 (1%) | 0% | 77.7 | 1,442,751 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 76.09 per share. | 19 Jul 2021 | 43,928 | 840,124 (1%) | 0% | 76.1 | 3,342,438 | Common Stock |
| L. Mary Smith | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.30 per share. | 13 Jul 2021 | 10,000 | 177,511 (0%) | 0% | 2.3 | 23,000 | Common Stock |
| L. Mary Smith | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jul 2021 | 10,000 | 94,296 | - | - | Stock Option (Right to Buy) | |
| L. Mary Smith | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 80.88 per share. | 13 Jul 2021 | 10,000 | 167,511 (0%) | 0% | 80.9 | 808,777 | Common Stock |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 85.35 per share. | 01 Jul 2021 | 32,000 | 301,541 (0%) | 0% | 85.3 | 2,731,088 | Common Stock |
| Freda C. Lewis-Hall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 1,106 | 25,227 (0%) | 0% | 0 | Common Stock | |
| Freda C. Lewis-Hall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 6,998 | 6,998 | - | - | Stock Option (Right to Buy) | |
| Stephen P. Squinto | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 6,998 | 6,998 | - | - | Stock Option (Right to Buy) | |
| Stephen P. Squinto | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 1,106 | 126,834 (0%) | 0% | 0 | Common Stock | |
| Alan Fuhrman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 6,998 | 6,998 | - | - | Stock Option (Right to Buy) | |
| Alan Fuhrman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 1,106 | 25,227 (0%) | 0% | 0 | Common Stock | |
| Daniel S. Lynch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 6,998 | 6,998 | - | - | Stock Option (Right to Buy) | |
| Daniel S. Lynch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 1,106 | 292,383 (0%) | 0% | 0 | Common Stock | |
| Julie Hambleton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 1,106 | 5,995 (0%) | 0% | 0 | Common Stock | |
| Julie Hambleton | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 6,998 | 6,998 | - | - | Stock Option (Right to Buy) | |
| Jeffrey Schwartz, | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 1,106 | 1,106 (0%) | 0% | 0 | Common Stock | |
| Jeffrey Schwartz, | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2021 | 6,998 | 6,998 | - | - | Stock Option (Right to Buy) | |
| Stephen P. Squinto | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 76.20 per share. | 27 Apr 2021 | 19,231 | 125,728 (0%) | 0% | 76.2 | 1,465,437 | Common Stock |
| Stephen P. Squinto | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 75.05 per share. | 27 Apr 2021 | 201 | 144,959 (0%) | 0% | 75.0 | 15,085 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 69.04 per share. | 19 Apr 2021 | 38,425 | 908,127 (2%) | 0% | 69.0 | 2,652,827 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 66.39 per share. | 19 Apr 2021 | 24,075 | 884,052 (2%) | 0% | 66.4 | 1,598,279 | Common Stock |
| Stephen P. Squinto | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 75.02 per share. | 14 Apr 2021 | 1,057 | 145,160 (0%) | 0% | 75.0 | 79,291 | Common Stock |
| Stephen P. Squinto | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 75.08 per share. | 14 Apr 2021 | 511 | 146,217 (0%) | 0% | 75.1 | 38,365 | Common Stock |
| L. Mary Smith | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.30 per share. | 13 Apr 2021 | 10,000 | 177,511 (0%) | 0% | 2.3 | 23,000 | Common Stock |
| L. Mary Smith | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Apr 2021 | 10,000 | 104,296 | - | - | Stock Option (Right to Buy) | |
| L. Mary Smith | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 68.07 per share. | 13 Apr 2021 | 10,000 | 167,511 (0%) | 0% | 68.1 | 680,723 | Common Stock |
| Bhavesh Ashar | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 12,500 | 12,500 (0%) | 0% | 0 | Common Stock | |
| Bhavesh Ashar | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2021 | 92,000 | 92,000 | - | - | Stock Option (Right to Buy) | |
| Badreddin Edris | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 84.07 per share. | 25 Jan 2021 | 32,000 | 261,542 (0%) | 0% | 84.1 | 2,690,282 | Common Stock |
| L. Mary Smith | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.30 per share. | 20 Jan 2021 | 8,872 | 177,511 (0%) | 0% | 2.3 | 20,406 | Common Stock |
| L. Mary Smith | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2021 | 8,872 | 114,296 | - | - | Stock Option (Right to Buy) | |
| L. Mary Smith | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2021 | 1,128 | 1,451 | - | - | Stock Option (Right to Buy) | |
| L. Mary Smith | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 78.70 per share. | 20 Jan 2021 | 10,000 | 167,511 (0%) | 0% | 78.7 | 787,016 | Common Stock |
| L. Mary Smith | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.65 per share. | 20 Jan 2021 | 1,128 | 168,639 (0%) | 0% | 1.6 | 1,861 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 78.75 per share. | 19 Jan 2021 | 2,199 | 1,222,997 (2%) | 0% | 78.8 | 173,180 | Common Stock |
| Saqib Islam | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 78.54 per share. | 19 Jan 2021 | 60,301 | 1,225,196 (2%) | 0% | 78.5 | 4,736,209 | Common Stock |
| Herschel S. Weinstein | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 56,000 | 56,000 | - | - | Stock Option (Right to Buy) | |
| Herschel S. Weinstein | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 7,000 | 7,000 (0%) | 0% | 0 | Common Stock | |
| Francis I. Perier | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 10,000 | 10,000 (0%) | 0% | 0 | Common Stock | |
| Francis I. Perier | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| Saqib Islam | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 37,500 | 1,285,497 (2%) | 0% | 0 | Common Stock | |
| Saqib Islam | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Michael Nofi | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 24,000 | 24,000 | - | - | Stock Option (Right to Buy) | |
| Michael Nofi | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 3,000 | 3,000 (0%) | 0% | 0 | Common Stock | |
| Jens Renstrup | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 48,600 | 48,600 | - | - | Stock Option (Right to Buy) | |
| Jens Renstrup | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 6,075 | 250,499 (0%) | 0% | 0 | Common Stock | |
| Badreddin Edris | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 13,000 | 293,542 (0%) | 0% | 0 | Common Stock | |
| Badreddin Edris | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 104,000 | 104,000 | - | - | Stock Option (Right to Buy) | |
| L. Mary Smith | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 11,000 | 167,511 (0%) | 0% | 0 | Common Stock | |
| L. Mary Smith | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 88,000 | 88,000 | - | - | Stock Option (Right to Buy) | |
| Daniel Pichl | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 4,150 | 4,150 (0%) | 0% | 0 | Common Stock | |
| Daniel Pichl | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 33,200 | 33,200 | - | - | Stock Option (Right to Buy) | |
| Daniel Pichl | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Aug 2020 | 75,000 | 75,000 | - | - | Stock Option (Right to Buy) | |
| Freda C. Lewis-Hall | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2020 | 7,464 | 7,464 | - | - | Stock Option (Right to Buy) | |
| Stephen P. Squinto | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2020 | 7,464 | 7,464 | - | - | Stock Option (Right to Buy) | |
| Alan Fuhrman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2020 | 7,464 | 7,464 | - | - | Stock Option (Right to Buy) | |
| Daniel S. Lynch | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2020 | 7,464 | 7,464 | - | - | Stock Option (Right to Buy) | |
| Julie Hambleton | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2020 | 14,668 | 14,668 | - | - | Stock Option (Right to Buy) | |
| Jeffrey Schwartz, | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2020 | 7,464 | 7,464 | - | - | Stock Option (Right to Buy) | |
| Stephen P. Squinto | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Mar 2020 | 20,000 | 20,000 | - | - | Common Stock | |
| Herschel S. Weinstein | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 106,600 | 106,600 | - | - | Stock Option (Right to Buy) | |
| Freda C. Lewis-Hall | Director, Ten Percent Owner | 17 Sep 2019 | 526,602 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Freda C. Lewis-Hall | Director, Ten Percent Owner | 17 Sep 2019 | 3,039,051 | 0 | - | - | Series A Convertible Preferred Stock | ||
| Freda C. Lewis-Hall | Director, Ten Percent Owner | 17 Sep 2019 | 978,194 | 978,194 (2%) | 2% | 0 | Common Stock | ||
| Freda C. Lewis-Hall | Director, Ten Percent Owner | 17 Sep 2019 | 3,039,051 | 4,017,245 (9%) | 7% | 0 | Common Stock | ||
| Freda C. Lewis-Hall | Director, Ten Percent Owner | 17 Sep 2019 | 526,602 | 4,543,847 (10%) | 1% | 0 | Common Stock | ||
| Freda C. Lewis-Hall | Director, Ten Percent Owner | 17 Sep 2019 | 978,194 | 0 | - | - | Junior Series A Convertible Preferred Stock | ||
| Freda C. Lewis-Hall | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 18.00 per share. | 17 Sep 2019 | 50,000 | 4,593,847 (10%) | 0% | 18 | 900,000 | Common Stock |
| Stephen P. Squinto | Director, Ten Percent Owner | 17 Sep 2019 | 6,078,103 | 6,078,103 (14%) | 14% | 0 | Common Stock | ||
| Stephen P. Squinto | Director, Ten Percent Owner | 17 Sep 2019 | 1,053,204 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Stephen P. Squinto | Director, Ten Percent Owner | 17 Sep 2019 | 6,078,103 | 0 | - | - | Series A Convertible Preferred Stock | ||
| Stephen P. Squinto | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 18.00 per share. | 17 Sep 2019 | 275,000 | 7,406,307 (17%) | 0% | 18 | 4,950,000 | Common Stock |
| Stephen P. Squinto | Director, Ten Percent Owner | 17 Sep 2019 | 1,053,204 | 7,131,307 (16%) | 2% | 0 | Common Stock |