1.1M XNAS Volume
XNAS 04 Apr, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 2.78 per share. | 31 Mar 2025 | 150,000 | 2,513,642 (4%) | 0% | 2.8 | 416,250 | Common Stock |
| Robert Lutz | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.83 per share. | 13 Feb 2025 | 38,263 | 361,737 (0%) | 0% | 2.8 | 108,284 | Common Stock |
| Raymond Pratt | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 80,000 | 340,050 (0%) | 0% | 0 | Common Stock | |
| David A. Ramsay | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 40,000 | 2,363,642 (4%) | 0% | 0 | Common Stock | |
| Nevan Charles Elam | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 40,000 | 62,500 (0%) | 0% | 0 | Common Stock | |
| Richard J. Hawkins | Director | Sale of securities on an exchange or to another person at price $ 3.32 per share. | 12 Dec 2024 | 8,000 | 67,241 (0%) | 0% | 3.3 | 26,569 | Common Stock |
| Richard J. Hawkins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 40,000 | 75,241 (0%) | 0% | 0 | Common Stock | |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 3.33 per share. | 12 Dec 2024 | 25,000 | 381,005 (0%) | 0% | 3.3 | 83,278 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Dec 2024 | 12,000 | 430,355 (0%) | 0% | 0 | Common Stock | |
| David L. Lowrance | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 100,000 | 442,355 (0%) | 0% | 0 | Common Stock | |
| David L. Lowrance | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| David L. Lowrance | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.21 per share. | 12 Dec 2024 | 24,350 | 406,005 (0%) | 0% | 3.2 | 78,164 | Common Stock |
| Raymond Pratt | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 280,000 | 280,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 900,000 | 900,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.21 per share. | 12 Dec 2024 | 92,593 | 1,591,081 (3%) | 0% | 3.2 | 297,224 | Common Stock |
| Braden C. Parker | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 20,000 | 105,000 (0%) | 0% | 0 | Common Stock | |
| Braden C. Parker | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Anne Erickson | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 100,000 | 452,935 (0%) | 0% | 0 | Common Stock | |
| Anne Erickson | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.21 per share. | 12 Dec 2024 | 18,263 | 434,672 (0%) | 0% | 3.2 | 58,624 | Common Stock |
| Anne Erickson | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Es-Johansson An van | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 40,000 | 62,500 (0%) | 0% | 0 | Common Stock | |
| Robert Lutz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 100,000 | 400,000 (0%) | 0% | 0 | Common Stock | |
| Robert Lutz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Joseph S. McCracken | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 40,000 | 250,837 (0%) | 0% | 0 | Common Stock | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2024 | 400,000 | 1,683,674 (3%) | 0% | 0 | Common Stock | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 3.31 per share. | 12 Dec 2024 | 54,702 | 1,536,379 (3%) | 0% | 3.3 | 180,828 | Common Stock |
| Joseph S. McCracken | Director | Purchase of securities on an exchange or from another person at price $ 2.95 per share. | 19 Nov 2024 | 20,000 | 210,837 (0%) | 0% | 3.0 | 59,072 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 2.88 per share. | 18 Nov 2024 | 100,000 | 2,323,642 (4%) | 0% | 2.9 | 287,600 | Common Stock |
| Raymond Pratt | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.97 per share. | 10 Nov 2024 | 49,950 | 260,050 (0%) | 0% | 4.0 | 198,302 | Common Stock |
| Anne Erickson | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.57 per share. | 21 Oct 2024 | 381 | 352,935 (0%) | 0% | 3.6 | 1,360 | Common Stock |
| Braden C. Parker | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2024 | 170,000 | 170,000 | - | - | Stock Option (Right to Buy) | |
| Braden C. Parker | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2024 | 85,000 | 85,000 (0%) | 0% | 0 | Common Stock | |
| Anne Erickson | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.47 per share. | 21 Jul 2024 | 381 | 353,316 (0%) | 0% | 4.5 | 1,703 | Common Stock |
| Anne Erickson | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.81 per share. | 21 Apr 2024 | 381 | 353,697 (0%) | 0% | 4.8 | 1,833 | Common Stock |
| Elam Nevan Charles | Director | Sale of securities on an exchange or to another person at price $ 4.71 per share. | 28 Dec 2023 | 93,843 | 22,500 (0%) | 0% | 4.7 | 442,291 | Common Stock |
| Elam Charles Nevan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.23 per share. | 28 Dec 2023 | 40,000 | 116,343 (0%) | 0% | 1.2 | 49,200 | Common Stock |
| Elam Nevan Charles | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.59 per share. | 28 Dec 2023 | 12,000 | 76,343 (0%) | 0% | 1.6 | 19,080 | Common Stock |
| Charles Elam Nevan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2023 | 1,758 | 0 | - | - | Stock Option (Right to Buy) | |
| Elam Charles Nevan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2023 | 12,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Lowrance David L. | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 4.71 per share. | 28 Dec 2023 | 10,000 | 342,355 (0%) | 0% | 4.7 | 47,131 | Common Stock |
| Nevan Charles Elam | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.82 per share. | 28 Dec 2023 | 1,758 | 64,343 (0%) | 0% | 0.8 | 1,442 | Common Stock |
| Pauls Matthew | Director, CHIEF EXECUTIVE OFFICER | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Dec 2023 | 19,000 | 1,283,674 (2%) | 0% | 0 | Common Stock | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 4.71 per share. | 28 Dec 2023 | 84,000 | 1,302,674 (2%) | 0% | 4.7 | 395,900 | Common Stock |
| Charles Nevan Elam | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2023 | 40,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Richard Hawkins J. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2023 | 22,500 | 35,241 (0%) | 0% | 0 | Common Stock | |
| Raymond Pratt | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 150,000 | 310,000 (0%) | 0% | 0 | Common Stock | |
| van An Es-Johansson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 22,500 | 22,500 (0%) | 0% | 0 | Common Stock | |
| David Lowrance L. | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Pauls Matthew | Director, CHIEF EXECUTIVE OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.45 per share. | 14 Dec 2023 | 109,680 | 936,674 (1%) | 0% | 4.5 | 488,076 | Common Stock |
| Robert Lutz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| L. Sun Ricky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 22,500 | 22,500 (0%) | 0% | 0 | Common Stock | |
| Nevan Elam Charles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 22,500 | 62,585 (0%) | 0% | 0 | Common Stock | |
| L. David Lowrance | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 160,000 | 372,355 (0%) | 0% | 0 | Common Stock | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 225,000 | 225,000 | - | - | Stock Option (Right to Buy) | |
| Joseph McCracken S. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 22,500 | 190,837 (0%) | 0% | 0 | Common Stock | |
| David L. Lowrance | CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.45 per share. | 14 Dec 2023 | 30,438 | 212,355 (0%) | 0% | 4.4 | 135,449 | Common Stock |
| Pratt Raymond | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Lutz Robert | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 160,000 | 300,000 (0%) | 0% | 0 | Common Stock | |
| David A. Ramsay | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 22,500 | 2,223,642 (4%) | 0% | 0 | Common Stock | |
| Pauls Matthew | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 450,000 | 1,386,674 (2%) | 0% | 0 | Common Stock | |
| Lowrance L. David | CHIEF FINANCIAL OFFICER | Gift of securities by or to the insider at price $ 0.00 per share. | 14 Dec 2023 | 20,000 | 352,355 (0%) | 0% | 0 | Common Stock | |
| Elam Nevan Charles | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2023 | 10,841 | 0 | - | - | Stock Option (Right to Buy) | |
| Hawkins J. Richard | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.82 per share. | 11 Dec 2023 | 10,841 | 12,741 (0%) | 0% | 0.8 | 8,890 | Common Stock |
| Nevan Charles Elam | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.82 per share. | 11 Dec 2023 | 10,841 | 40,085 (0%) | 0% | 0.8 | 8,890 | Common Stock |
| Richard Hawkins J. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2023 | 10,841 | 0 | - | - | Stock Option (Right to Buy) | |
| Raymond Pratt | Chief Medical Officer | Purchase of securities on an exchange or from another person at price $ 2.93 per share. | 26 Jun 2023 | 6,500 | 160,000 (0%) | 0% | 2.9 | 19,045 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 2.56 per share. | 24 May 2023 | 50,000 | 2,151,142 (4%) | 0% | 2.6 | 127,800 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 2.57 per share. | 24 May 2023 | 12,876 | 2,164,018 (4%) | 0% | 2.6 | 33,130 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 2.63 per share. | 24 May 2023 | 37,124 | 2,201,142 (4%) | 0% | 2.6 | 97,599 | Common Stock |
| Robert Lutz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 140,000 | 140,000 (0%) | 0% | 0 | Common Stock | |
| Robert Lutz | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 350,000 | 350,000 | - | - | Stock Option (Right to Buy) | |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.54 per share. | 29 Dec 2022 | 7,000 | 2,072,142 (4%) | 0% | 1.5 | 10,752 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.55 per share. | 29 Dec 2022 | 29,000 | 2,101,142 (4%) | 0% | 1.5 | 44,834 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.49 per share. | 23 Dec 2022 | 3,293 | 2,065,142 (4%) | 0% | 1.5 | 4,923 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.44 per share. | 23 Dec 2022 | 15,707 | 2,061,849 (4%) | 0% | 1.4 | 22,665 | Common Stock |
| Raymond Pratt | Chief Medical Officer | Purchase of securities on an exchange or from another person at price $ 1.54 per share. | 22 Dec 2022 | 3,500 | 153,500 (0%) | 0% | 1.5 | 5,402 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.48 per share. | 20 Dec 2022 | 41,414 | 2,046,142 (4%) | 0% | 1.5 | 61,127 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.48 per share. | 20 Dec 2022 | 3,586 | 2,004,728 (3%) | 0% | 1.5 | 5,307 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.49 per share. | 16 Dec 2022 | 40,719 | 1,987,312 (3%) | 0% | 1.5 | 60,834 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.50 per share. | 16 Dec 2022 | 13,830 | 2,001,142 (3%) | 0% | 1.5 | 20,759 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.50 per share. | 16 Dec 2022 | 341 | 1,946,593 (3%) | 0% | 1.5 | 512 | Common Stock |
| David A. Ramsay | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Nevan Charles Elam | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Nevan Charles Elam | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 13 Dec 2022 | 1,172 | 29,244 (0%) | 0% | 0.7 | 762 | Common Stock |
| Nevan Charles Elam | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2022 | 1,172 | 0 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| David L. Lowrance | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 250,000 | 250,000 | - | - | Stock Option (Right to Buy) | |
| David L. Lowrance | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 100,000 | 242,793 (0%) | 0% | 0 | Common Stock | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 700,000 | 700,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 325,000 | 1,046,354 (2%) | 0% | 0 | Common Stock | |
| Joseph S. McCracken | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Es-Johansson An van | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Ricky L. Sun | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2022 | 1,172 | 0 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 07 Dec 2022 | 1,172 | 1,900 (0%) | 0% | 0.7 | 762 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.42 per share. | 22 Nov 2022 | 15,495 | 1,941,642 (3%) | 0% | 1.4 | 22,018 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.44 per share. | 22 Nov 2022 | 4,610 | 1,946,252 (3%) | 0% | 1.4 | 6,634 | Common Stock |
| Raymond Pratt | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Nov 2022 | 375,000 | 375,000 | - | - | Stock Option (Right to Buy) | |
| Raymond Pratt | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Nov 2022 | 150,000 | 150,000 (0%) | 0% | 0 | Common Stock | |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.34 per share. | 17 Nov 2022 | 16,100 | 1,901,142 (3%) | 0% | 1.3 | 21,606 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.42 per share. | 17 Nov 2022 | 25,005 | 1,926,147 (3%) | 0% | 1.4 | 35,532 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.27 per share. | 17 Nov 2022 | 8,900 | 1,885,042 (3%) | 0% | 1.3 | 11,303 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.38 per share. | 23 Sep 2022 | 31,107 | 1,802,249 (3%) | 0% | 1.4 | 43,052 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.37 per share. | 23 Sep 2022 | 73,893 | 1,876,142 (3%) | 0% | 1.4 | 101,381 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.42 per share. | 23 Sep 2022 | 30,000 | 1,771,142 (3%) | 0% | 1.4 | 42,660 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.46 per share. | 16 Sep 2022 | 1,400 | 1,740,542 (3%) | 0% | 1.5 | 2,040 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.45 per share. | 16 Sep 2022 | 600 | 1,741,142 (3%) | 0% | 1.5 | 870 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.44 per share. | 16 Sep 2022 | 6,000 | 1,739,142 (3%) | 0% | 1.4 | 8,652 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.38 per share. | 06 Sep 2022 | 2,130 | 1,704,142 (3%) | 0% | 1.4 | 2,950 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.40 per share. | 06 Sep 2022 | 29,000 | 1,733,142 (3%) | 0% | 1.4 | 40,571 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.38 per share. | 06 Sep 2022 | 870 | 1,702,012 (3%) | 0% | 1.4 | 1,201 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.42 per share. | 30 Aug 2022 | 39,494 | 1,661,374 (3%) | 0% | 1.4 | 56,200 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.42 per share. | 30 Aug 2022 | 39,768 | 1,701,142 (3%) | 0% | 1.4 | 56,471 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.41 per share. | 30 Aug 2022 | 20,738 | 1,621,880 (3%) | 0% | 1.4 | 29,261 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.38 per share. | 17 Jun 2022 | 21,094 | 1,562,142 (3%) | 0% | 1.4 | 29,110 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.44 per share. | 17 Jun 2022 | 39,000 | 1,601,142 (3%) | 0% | 1.4 | 56,355 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.33 per share. | 17 Jun 2022 | 39,906 | 1,541,048 (3%) | 0% | 1.3 | 52,915 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.24 per share. | 29 Dec 2021 | 15,000 | 1,466,142 (2%) | 0% | 1.2 | 18,675 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.30 per share. | 29 Dec 2021 | 35,000 | 1,501,142 (2%) | 0% | 1.3 | 45,360 | Common Stock |
| David L. Lowrance | CHIEF FINANCIAL OFFICER | Purchase of securities on an exchange or from another person at price $ 1.14 per share. | 17 Dec 2021 | 4,000 | 142,793 (0%) | 0% | 1.1 | 4,569 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.13 per share. | 15 Dec 2021 | 25,000 | 1,451,142 (2%) | 0% | 1.1 | 28,225 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.08 per share. | 15 Dec 2021 | 15,000 | 1,426,142 (2%) | 0% | 1.1 | 16,260 | Common Stock |
| David A. Ramsay | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Nevan C. Elam | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| David L. Lowrance | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| David L. Lowrance | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 125,000 | 138,793 (0%) | 0% | 0 | Common Stock | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 350,000 | 350,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 400,000 | 783,672 (1%) | 0% | 0 | Common Stock | |
| Joseph S. McCracken | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Badrul A. Chowdhury | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Badrul A. Chowdhury | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 125,000 | 300,000 (0%) | 0% | 0 | Common Stock | |
| Es-Johansson An van | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Ricky L. Sun | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2021 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2021 | 728 | 0 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.55 per share. | 13 Dec 2021 | 728 | 728 (0%) | 0% | 0.5 | 400 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.04 per share. | 10 Dec 2021 | 35,000 | 1,411,142 (2%) | 0% | 1.0 | 36,365 | Common Stock |
| Badrul A. Chowdhury | CHIEF MEDICAL OFFICER | Purchase of securities on an exchange or from another person at price $ 1.05 per share. | 09 Dec 2021 | 25,000 | 175,000 (0%) | 0% | 1.1 | 26,250 | Common Stock |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 1.06 per share. | 08 Dec 2021 | 6,500 | 383,672 (0%) | 0% | 1.1 | 6,889 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.05 per share. | 07 Dec 2021 | 11,843 | 1,362,985 (2%) | 0% | 1.0 | 12,400 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.05 per share. | 07 Dec 2021 | 13,157 | 1,376,142 (2%) | 0% | 1.1 | 13,815 | Common Stock |
| Nevan C. Elam | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2021 | 1,172 | 0 | - | - | Stock Option (Right to Buy) | |
| Nevan C. Elam | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.55 per share. | 06 Dec 2021 | 1,172 | 28,072 (0%) | 0% | 0.6 | 645 | Common Stock |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 1.10 per share. | 02 Dec 2021 | 10,000 | 377,172 (0%) | 0% | 1.1 | 10,954 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.09 per share. | 01 Dec 2021 | 21,394 | 1,351,142 (2%) | 0% | 1.1 | 23,234 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.08 per share. | 01 Dec 2021 | 3,606 | 1,329,748 (2%) | 0% | 1.1 | 3,894 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.08 per share. | 29 Nov 2021 | 9,000 | 1,326,142 (2%) | 0% | 1.1 | 9,765 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.09 per share. | 29 Nov 2021 | 16,000 | 1,317,142 (2%) | 0% | 1.1 | 17,392 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.08 per share. | 18 Nov 2021 | 90,000 | 1,301,142 (2%) | 0% | 1.1 | 97,020 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.07 per share. | 18 Nov 2021 | 49,800 | 1,211,142 (2%) | 0% | 1.1 | 53,236 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.08 per share. | 18 Nov 2021 | 60,200 | 1,161,342 (2%) | 0% | 1.1 | 65,136 | Common Stock |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 1.10 per share. | 18 Nov 2021 | 10,000 | 355,022 (0%) | 0% | 1.1 | 11,000 | Common Stock |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 1.07 per share. | 18 Nov 2021 | 2,150 | 367,172 (0%) | 0% | 1.1 | 2,290 | Common Stock |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 1.11 per share. | 18 Nov 2021 | 10,000 | 365,022 (0%) | 0% | 1.1 | 11,100 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.28 per share. | 28 Sep 2021 | 47,500 | 1,051,142 (2%) | 0% | 1.3 | 60,658 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.30 per share. | 28 Sep 2021 | 50,000 | 1,101,142 (2%) | 0% | 1.3 | 64,900 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.28 per share. | 28 Sep 2021 | 39,552 | 1,003,642 (1%) | 0% | 1.3 | 50,824 | Common Stock |
| Nevan C. Elam | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Aug 2021 | 2,288 | 0 | - | - | Stock Option (Right to Buy) | |
| Nevan C. Elam | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.52 per share. | 18 Aug 2021 | 2,288 | 26,900 (0%) | 0% | 0.5 | 1,190 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.18 per share. | 17 Aug 2021 | 12,948 | 946,302 (1%) | 0% | 1.2 | 15,279 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.22 per share. | 17 Aug 2021 | 17,788 | 964,090 (1%) | 0% | 1.2 | 21,701 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.18 per share. | 17 Aug 2021 | 66,554 | 933,354 (1%) | 0% | 1.2 | 78,201 | Common Stock |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 1.18 per share. | 17 Aug 2021 | 15,000 | 333,122 (0%) | 0% | 1.2 | 17,700 | Common Stock |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 1.19 per share. | 17 Aug 2021 | 11,900 | 345,022 (0%) | 0% | 1.2 | 14,166 | Common Stock |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 1.63 per share. | 21 May 2021 | 10,000 | 318,122 (0%) | 0% | 1.6 | 16,298 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.58 per share. | 19 May 2021 | 5,003 | 866,800 (1%) | 0% | 1.6 | 7,905 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.62 per share. | 18 May 2021 | 50,000 | 861,797 (1%) | 0% | 1.6 | 81,100 | Common Stock |
| Badrul A. Chowdhury | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 1.56 per share. | 15 May 2021 | 50,000 | 150,000 (0%) | 0% | 1.6 | 77,870 | Common Stock |
| Badrul A. Chowdhury | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2021 | 200,000 | 0 | - | - | Restricted Stock Units | |
| Badrul A. Chowdhury | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2021 | 200,000 | 200,000 (0%) | 0% | 0 | Common Stock | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 1.82 per share. | 19 Apr 2021 | 27,400 | 308,122 (0%) | 0% | 1.8 | 49,871 | Common Stock |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 2.07 per share. | 22 Mar 2021 | 24,100 | 280,722 (0%) | 0% | 2.1 | 49,938 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 1.45 per share. | 15 Mar 2021 | 689,655 | 811,797 (1%) | 1% | 1.5 | 1,000,000 | Common Stock |
| David L. Lowrance | CHIEF FINANCIAL OFFICER | Purchase of securities on an exchange or from another person at price $ 1.45 per share. | 15 Mar 2021 | 13,793 | 13,793 (0%) | 0% | 1.5 | 20,000 | Common Stock |
| Joseph S. McCracken | Director | Purchase of securities on an exchange or from another person at price $ 1.45 per share. | 15 Mar 2021 | 68,965 | 168,337 (0%) | 0% | 1.4 | 99,999 | Common Stock |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Purchase of securities on an exchange or from another person at price $ 1.74 per share. | 22 Feb 2021 | 28,700 | 256,622 (0%) | 0% | 1.7 | 50,038 | Common Stock |
| David A. Ramsay | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2020 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2020 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| David L. Lowrance | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2020 | 260,000 | 260,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2020 | 500,000 | 500,000 | - | - | Stock Option (Right to Buy) | |
| Joseph S. McCracken | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2020 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Badrul A. Chowdhury | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2020 | 275,000 | 275,000 | - | - | Stock Option (Right to Buy) | |
| Es-Johansson An van | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2020 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Ricky L Sun | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2020 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Nevan C. Elam | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2020 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Nevan C. Elam | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2020 | 2,930 | 0 | - | - | Stock Option (Right to Buy) | |
| Nevan C. Elam | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.52 per share. | 15 Dec 2020 | 2,930 | 24,612 (0%) | 0% | 0.5 | 1,524 | Common Stock |
| Ricky L Sun | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2020 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| David A. Ramsay | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2019 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Nevan C. Elam | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2019 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2019 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Taneli Jouhikainen | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2019 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| David L. Lowrance | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2019 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2019 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Joseph S. McCracken | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2019 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Roberto Neville | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2019 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Es-Johansson An van | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2019 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Badrul A. Chowdhury | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Nov 2019 | 200,000 | 200,000 | - | - | Restricted Stock Units | |
| Badrul A. Chowdhury | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Nov 2019 | 300,000 | 300,000 | - | - | Stock Option (Right to Buy) | |
| Joseph S. McCracken | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.82 per share. | 05 Jul 2019 | 21,682 | 81,548 (0%) | 0% | 0.8 | 17,779 | Common Stock |
| Joseph S. McCracken | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.82 per share. | 05 Jul 2019 | 2,930 | 84,478 (0%) | 0% | 0.8 | 2,403 | Common Stock |
| Joseph S. McCracken | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2019 | 9,034 | 1,807 | - | - | Stock Option (Right to Buy) | |
| Joseph S. McCracken | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2019 | 5,860 | 0 | - | - | Stock Option (Right to Buy) | |
| Joseph S. McCracken | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2019 | 2,930 | 0 | - | - | Stock Option (Right to Buy) | |
| Joseph S. McCracken | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2019 | 21,682 | 0 | - | - | Stock Option (Right to Buy) | |
| Joseph S. McCracken | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.76 per share. | 05 Jul 2019 | 9,034 | 99,372 (0%) | 0% | 1.8 | 15,900 | Common Stock |
| Joseph S. McCracken | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.46 per share. | 05 Jul 2019 | 5,860 | 90,338 (0%) | 0% | 1.5 | 8,556 | Common Stock |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 2.36 per share. | 26 Jun 2019 | 5,000 | 122,142 (0%) | 0% | 2.4 | 11,800 | Common Stock |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 2.40 per share. | 26 Jun 2019 | 5,000 | 79,685 (0%) | 0% | 2.4 | 12,000 | Common Stock |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 2.39 per share. | 26 Jun 2019 | 5,000 | 84,685 (0%) | 0% | 2.4 | 11,950 | Common Stock |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 2.38 per share. | 26 Jun 2019 | 2,300 | 86,985 (0%) | 0% | 2.4 | 5,474 | Common Stock |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 2.33 per share. | 26 Jun 2019 | 18,000 | 104,985 (0%) | 0% | 2.3 | 41,940 | Common Stock |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 2.35 per share. | 26 Jun 2019 | 12,157 | 117,142 (0%) | 0% | 2.4 | 28,569 | Common Stock |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 2.45 per share. | 26 Jun 2019 | 5,000 | 69,685 (0%) | 0% | 2.5 | 12,250 | Common Stock |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 2.38 per share. | 26 Jun 2019 | 900 | 64,685 (0%) | 0% | 2.4 | 2,142 | Common Stock |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 2.42 per share. | 26 Jun 2019 | 5,000 | 74,685 (0%) | 0% | 2.4 | 12,100 | Common Stock |
| Richard J. Hawkins | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2019 | 444 | 728 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.52 per share. | 14 May 2019 | 21,682 | 21,682 (0%) | 0% | 0.5 | 11,275 | Common Stock |
| Richard J. Hawkins | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.52 per share. | 14 May 2019 | 586 | 22,268 (0%) | 0% | 0.5 | 305 | Common Stock |
| Richard J. Hawkins | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.52 per share. | 14 May 2019 | 2,288 | 24,556 (0%) | 0% | 0.5 | 1,190 | Common Stock |
| Richard J. Hawkins | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.55 per share. | 14 May 2019 | 444 | 25,000 (0%) | 0% | 0.5 | 244 | Common Stock |
| Richard J. Hawkins | None | Sale of securities on an exchange or to another person at price $ 11.07 per share. | 14 May 2019 | 14,591 | 10,409 (0%) | 0% | 11.1 | 161,455 | Common Stock |
| Richard J. Hawkins | None | Sale of securities on an exchange or to another person at price $ 11.16 per share. | 14 May 2019 | 10,409 | 0 (0%) | 0% | 11.2 | 116,167 | Common Stock |
| Richard J. Hawkins | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2019 | 21,682 | 0 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2019 | 586 | 0 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2019 | 2,288 | 0 | - | - | Stock Option (Right to Buy) | |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.51 per share. | 01 May 2019 | 3,800 | 3,800 (0%) | 0% | 1.5 | 5,738 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2019 | 3,700 | 80,684 | - | - | Employee Stock Option (right to buy) | |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2019 | 3,800 | 84,384 | - | - | Employee Stock Option (right to buy) | |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.82 per share. | 01 May 2019 | 3,700 | 0 (0%) | 0% | 10.8 | 40,024 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.51 per share. | 01 May 2019 | 3,700 | 3,700 (0%) | 0% | 1.5 | 5,587 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.76 per share. | 01 May 2019 | 3,800 | 0 (0%) | 0% | 10.8 | 40,903 | Common Stock |
| Taneli Jouhikainen | President and COO | Sale of securities on an exchange or to another person at price $ 9.00 per share. | 04 Apr 2019 | 849 | 183,905 (0%) | 0% | 9 | 7,641 | Common Stock |
| Taneli Jouhikainen | President and COO | Sale of securities on an exchange or to another person at price $ 9.04 per share. | 04 Apr 2019 | 16,336 | 167,569 (0%) | 0% | 9.0 | 147,689 | Common Stock |
| Taneli Jouhikainen | President and COO | Sale of securities on an exchange or to another person at price $ 9.00 per share. | 04 Apr 2019 | 7,815 | 184,754 (0%) | 0% | 9 | 70,335 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 9.00 per share. | 04 Apr 2019 | 2,446 | 0 (0%) | 0% | 9 | 22,014 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Apr 2019 | 4,734 | 88,184 | - | - | Employee Stock Option (right to buy) | |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Apr 2019 | 320 | 92,918 | - | - | Employee Stock Option (right to buy) | |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Apr 2019 | 2,446 | 93,238 | - | - | Employee Stock Option (right to buy) | |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 9.04 per share. | 04 Apr 2019 | 4,734 | 0 (0%) | 0% | 9.0 | 42,780 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.51 per share. | 04 Apr 2019 | 4,734 | 4,734 (0%) | 0% | 1.5 | 7,148 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 9.00 per share. | 04 Apr 2019 | 320 | 0 (0%) | 0% | 9.0 | 2,881 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.51 per share. | 04 Apr 2019 | 320 | 320 (0%) | 0% | 1.5 | 483 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.51 per share. | 04 Apr 2019 | 2,446 | 2,446 (0%) | 0% | 1.5 | 3,693 | Common Stock |
| Nevan C. Elam | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Feb 2019 | 21,682 | 0 | - | - | Stock Option (Right to Buy) | |
| Nevan C. Elam | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.19 per share. | 04 Feb 2019 | 21,682 | 21,682 (0%) | 0% | 0.2 | 4,120 | Common Stock |
| Roberto Neville | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 6.38 per share. | 21 Dec 2018 | 23,517 | 498,028 (1%) | 0% | 6.4 | 149,994 | Common Stock |
| David A. Ramsay | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2018 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Nevan C. Elam | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2018 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2018 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2018 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Joseph S. McCracken | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2018 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Yuri Pikover | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2018 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 9.22 per share. | 01 Nov 2018 | 18,480 | 0 (0%) | 0% | 9.2 | 170,476 | Common Stock |
| Taneli Jouhikainen | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2018 | 375,000 | 375,000 | - | - | Stock Option (Right to Buy) | |
| David L. Lowrance | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2018 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Roberto Neville | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2018 | 400,000 | 400,000 | - | - | Stock Option (Right to Buy) | |
| Taneli Jouhikainen | See Remarks | Sale of securities on an exchange or to another person at price $ 12.11 per share. | 08 Jun 2018 | 2,638 | 207,688 (0%) | 0% | 12.1 | 31,950 | Common Stock |
| Taneli Jouhikainen | See Remarks | Sale of securities on an exchange or to another person at price $ 12.10 per share. | 08 Jun 2018 | 13,494 | 192,569 (0%) | 0% | 12.1 | 163,300 | Common Stock |
| Taneli Jouhikainen | See Remarks | Sale of securities on an exchange or to another person at price $ 12.02 per share. | 08 Jun 2018 | 1,625 | 206,063 (0%) | 0% | 12.0 | 19,539 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.05 per share. | 08 Jun 2018 | 700 | 22,380 (0%) | 0% | 12.1 | 8,436 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.08 per share. | 08 Jun 2018 | 3,900 | 18,480 (0%) | 0% | 12.1 | 47,105 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.13 per share. | 08 Jun 2018 | 675 | 23,080 (0%) | 0% | 12.1 | 8,187 | Common Stock |
| Roberto Neville | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 12.13 per share. | 08 Jun 2018 | 2,737 | 402,648 (1%) | 0% | 12.1 | 33,212 | Common Stock |
| Roberto Neville | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.43 per share. | 08 Jun 2018 | 5,252 | 489,747 (1%) | 0% | 11.4 | 60,030 | Common Stock |
| Roberto Neville | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 12.09 per share. | 08 Jun 2018 | 13,445 | 474,511 (1%) | 0% | 12.1 | 162,586 | Common Stock |
| Roberto Neville | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 12.01 per share. | 08 Jun 2018 | 1,791 | 487,956 (1%) | 0% | 12.0 | 21,513 | Common Stock |
| Roberto Neville | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jun 2018 | 92,351 | 0 | - | - | Stock Option (Right to Buy) | |
| Roberto Neville | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.65 per share. | 08 Jun 2018 | 92,351 | 494,999 (1%) | 0% | 0.6 | 60,028 | Common Stock |
| Yuri Pikover | None | Purchase of securities on an exchange or from another person at price $ 9.00 per share. | 29 Mar 2018 | 3,734 | 153,734 (0%) | 0% | 9.0 | 33,603 | Common Stock |
| Taneli Jouhikainen | See Remarks | Sale of securities on an exchange or to another person at price $ 13.05 per share. | 15 Feb 2018 | 8,890 | 210,326 (0%) | 0% | 13.0 | 115,982 | Common Stock |
| Taneli Jouhikainen | See Remarks | Sale of securities on an exchange or to another person at price $ 12.75 per share. | 15 Feb 2018 | 16,110 | 219,216 (0%) | 0% | 12.7 | 205,338 | Common Stock |
| Roberto Neville | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 13.08 per share. | 15 Feb 2018 | 9,476 | 405,385 (1%) | 0% | 13.1 | 123,917 | Common Stock |
| Roberto Neville | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 12.84 per share. | 15 Feb 2018 | 15,524 | 414,861 (1%) | 0% | 12.8 | 199,257 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 13.30 per share. | 02 Jan 2018 | 2,064 | 23,755 (0%) | 0% | 13.3 | 27,443 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.70 per share. | 02 Jan 2018 | 4,936 | 25,819 (0%) | 0% | 12.7 | 62,687 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 15.06 per share. | 02 Jan 2018 | 3,239 | 30,755 (0%) | 0% | 15.1 | 48,779 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.51 per share. | 02 Jan 2018 | 31,894 | 33,994 (0%) | 0% | 1.5 | 48,160 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2018 | 31,894 | 95,684 | - | - | Employee Stock Option (right to buy) | |
| Nevan C. Elam | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Dec 2017 | 3,750 | 3,750 | - | - | Stock Option (Right to Buy) | |
| Richard J. Hawkins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Dec 2017 | 3,750 | 3,750 | - | - | Stock Option (Right to Buy) | |
| Joseph S. McCracken | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Dec 2017 | 3,750 | 3,750 | - | - | Stock Option (Right to Buy) | |
| Yuri Pikover | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Dec 2017 | 3,750 | 3,750 | - | - | Stock Option (Right to Buy) | |
| Yuri Pikover | Director | Purchase of securities on an exchange or from another person at price $ 7.85 per share. | 27 Oct 2017 | 50,000 | 150,000 (0%) | 0% | 7.9 | 392,500 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 4.75 per share. | 07 Jun 2017 | 21,000 | 22,428 (0%) | 0% | 4.8 | 99,750 | Common Stock |
| Taneli Jouhikainen | See Remarks | Purchase of securities on an exchange or from another person at price $ 4.75 per share. | 07 Jun 2017 | 10,500 | 235,326 (0%) | 0% | 4.8 | 49,875 | Common Stock |
| David L. Lowrance | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 4.75 per share. | 07 Jun 2017 | 2,100 | 2,100 (0%) | 0% | 4.8 | 9,975 | Common Stock |
| Joseph S. McCracken | Director | Purchase of securities on an exchange or from another person at price $ 4.75 per share. | 07 Jun 2017 | 52,250 | 59,866 (0%) | 0% | 4.8 | 248,188 | Common Stock |
| Roberto Neville | Director, Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 4.75 per share. | 07 Jun 2017 | 52,250 | 430,385 (0%) | 0% | 4.8 | 248,188 | Common Stock |
| Yuri Pikover | Director | Purchase of securities on an exchange or from another person at price $ 4.75 per share. | 07 Jun 2017 | 100,000 | 100,000 (0%) | 0% | 4.8 | 475,000 | Common Stock |
| David A. Ramsay | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2017 | 3,750 | 3,750 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2017 | 3,750 | 3,750 | - | - | Stock Option (Right to Buy) | |
| David A. Ramsay | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2017 | 1,142 | 0 | - | - | Restricted Stock Units | |
| David A. Ramsay | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2017 | 1,142 | 23,570 (0%) | 0% | 0 | Common Stock | |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 2.39 per share. | 27 Apr 2017 | 10,000 | 33,570 (0%) | 0% | 2.4 | 23,900 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 2.38 per share. | 27 Apr 2017 | 10,000 | 43,570 (0%) | 0% | 2.4 | 23,800 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 2.37 per share. | 27 Apr 2017 | 5,000 | 48,570 (0%) | 0% | 2.4 | 11,850 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 2.35 per share. | 27 Apr 2017 | 10,215 | 63,785 (0%) | 0% | 2.3 | 24,005 | Common Stock |
| David A. Ramsay | Director | Purchase of securities on an exchange or from another person at price $ 2.36 per share. | 27 Apr 2017 | 5,000 | 53,570 (0%) | 0% | 2.4 | 11,800 | Common Stock |
| Matthew Pauls | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2017 | 227,272 | 227,922 (0%) | 0% | 0 | Common Stock | |
| Matthew Pauls | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2017 | 650 | 650 (0%) | 0% | 0 | Common Stock | |
| Matthew Pauls | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2017 | 650 | 0 | - | - | Restricted Stock Units | |
| Matthew Pauls | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2017 | 898,639 | 898,639 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2017 | 45,535 | 45,535 | - | - | Restricted Stock Units | |
| David A. Ramsay | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2017 | 79,962 | 79,962 | - | - | Restricted Stock Units | |
| Brian M. Culley | Director, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2017 | 2,368,194 | 2,368,194 | - | - | Restricted Stock Units | |
| Brandi L. Roberts | Chief Financial Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2017 | 889,926 | 889,926 | - | - | Restricted Stock Units | |
| Howard Dittrich | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2017 | 63,933 | 63,933 | - | - | Restricted Stock Units | |
| Edwin L. Parsley | Chief Medical Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2017 | 894,572 | 894,572 | - | - | Restricted Stock Units | |
| Shana Hood | General Counsel & VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2017 | 453,556 | 453,556 | - | - | Restricted Stock Units | |
| David A. Ramsay | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2016 | 79,551 | 79,551 | - | - | Stock Option (Right to Buy) | |
| Peter Lichtlen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2016 | 79,551 | 79,551 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2016 | 79,551 | 79,551 | - | - | Stock Option (Right to Buy) | |
| Howard Dittrich | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2016 | 79,551 | 79,551 | - | - | Stock Option (Right to Buy) | |
| R. Martin Emanuele | Senior VP, Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 572,700 | 572,700 | - | - | Employee Stock Option (Right to Buy) | |
| Brian M. Culley | Director, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 1,227,100 | 1,227,100 | - | - | Employee Stock Option (Right to Buy) | |
| Brandi L. Roberts | Chief Financial Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 572,700 | 572,700 | - | - | Employee Stock Option (Right to Buy) | |
| Gregory D. Gorgas | Senior VP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 572,700 | 572,700 | - | - | Employee Stock Option (Right to Buy) | |
| Edwin L. Parsley | Chief Medical Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 572,700 | 572,700 | - | - | Employee Stock Option (Right to Buy) | |
| Peter Lichtlen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Nov 2015 | 37,794 | 37,794 | - | - | Stock Option (Right to Buy) | |
| Peter Lichtlen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Nov 2015 | 64,791 | 64,791 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Oct 2015 | 37,794 | 37,794 | - | - | Stock Option (Right to Buy) | |
| Matthew Pauls | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Oct 2015 | 64,791 | 64,791 | - | - | Stock Option (Right to Buy) | |
| Jack Lief | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2015 | 82,963 | 82,963 | - | - | Stock Option (Right to Buy) | |
| R. Martin Emanuele | Senior VP, Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2015 | 291,500 | 291,500 | - | - | Employee Stock Option (Right to Buy) | |
| Lewis J. Shuster | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2015 | 82,963 | 82,963 | - | - | Stock Option (Right to Buy) | |
| Brian M. Culley | Director, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2015 | 888,900 | 888,900 | - | - | Employee Stock Option (Right to Buy) | |
| David A. Ramsay | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2015 | 82,963 | 82,963 | - | - | Stock Option (Right to Buy) | |
| Brandi L. Roberts | Chief Financial Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2015 | 444,400 | 444,400 | - | - | Employee Stock Option (Right to Buy) | |
| Gregory D. Gorgas | Senior VP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2015 | 417,100 | 417,100 | - | - | Employee Stock Option (Right to Buy) | |
| Howard Dittrich | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2015 | 82,963 | 82,963 | - | - | Stock Option (Right to Buy) | |
| Edwin L. Parsley | Chief Medical Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2015 | 555,850 | 555,850 | - | - | Employee Stock Option (Right to Buy) | |
| Brandi L. Roberts | Chief Financial Officer & SVP | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 26 Mar 2015 | 20,000 | 20,000 | - | - | Common Stock | |
| Brandi L. Roberts | Chief Financial Officer & SVP | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 26 Mar 2015 | 18,000 | 38,000 | - | - | Common Stock | |
| R. Martin Emanuele | Senior VP, Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2015 | 500,250 | 500,250 | - | - | Stock Option (Right to Buy) | |
| Brian M. Culley | Director, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2015 | 2,100,550 | 2,100,550 | - | - | Stock Option (Right to Buy) | |
| Patrick L. Keran | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2015 | 2,100,550 | 2,100,550 | - | - | Stock Option (Right to Buy) | |
| Brandi L. Roberts | Chief Financial Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2015 | 722,800 | 722,800 | - | - | Stock Option (Right to Buy) | |
| Gregory D. Gorgas | Senior VP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2015 | 622,800 | 622,800 | - | - | Stock Option (Right to Buy) | |
| Edwin L. Parsley | Chief Medical Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2015 | 938,300 | 938,300 | - | - | Stock Option (Right to Buy) | |
| Edwin L. Parsley | Chief Medical Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2014 | 600,000 | 600,000 | - | - | Employee Stock Option (Right to Buy) | |
| Jack Lief | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 46,609 | 46,609 | - | - | Stock Option (Right to Buy) | |
| R. Martin Emanuele | Senior VP, Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 285,400 | 285,400 | - | - | Stock Option (Right to Buy) | |
| Lewis J. Shuster | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 46,609 | 46,609 | - | - | Stock Option (Right to Buy) | |
| Brian M. Culley | Director, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 1,114,250 | 1,114,250 | - | - | Stock Option (Right to Buy) | |
| David A. Ramsay | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 46,609 | 46,609 | - | - | Stock Option (Right to Buy) | |
| Patrick L. Keran | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 1,114,250 | 1,114,250 | - | - | Stock Option (Right to Buy) | |
| Santosh Vetticaden | Chief Medical Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 529,300 | 529,300 | - | - | Stock Option (Right to Buy) | |
| Brandi L. Roberts | Chief Financial Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 336,600 | 336,600 | - | - | Stock Option (Right to Buy) | |
| Gregory D. Gorgas | Senior VP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 320,650 | 320,650 | - | - | Stock Option (Right to Buy) | |
| Howard Dittrich | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 46,609 | 46,609 | - | - | Stock Option (Right to Buy) | |
| Howard Dittrich | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 46,609 | 46,609 | - | - | Stock Option (Right to Buy) | |
| R. Martin Emanuele | Senior VP, Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2014 | 115,900 | 115,900 | - | - | Employee Stock Option (Right to Buy) | |
| Brian M. Culley | Director, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2014 | 650,300 | 650,300 | - | - | Employee Stock Option (Right to Buy) | |
| Patrick L. Keran | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2014 | 650,300 | 650,300 | - | - | Employee Stock Option (Right to Buy) | |
| Santosh Vetticaden | Chief Medical Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2014 | 295,100 | 295,100 | - | - | Employee Stock Option (Right to Buy) | |
| Brandi L. Roberts | Chief Financial Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2014 | 101,200 | 101,200 | - | - | Employee Stock Option (Right to Buy) | |
| Gregory D. Gorgas | Senior VP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2014 | 49,500 | 49,500 | - | - | Employee Stock Option (Right to Buy) | |
| Jack Lief | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2013 | 62,451 | 62,451 | - | - | Stock Option (Right to Buy) | |
| Lewis J. Shuster | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2013 | 62,451 | 62,451 | - | - | Stock Option (Right to Buy) | |
| Ted W. Love | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2013 | 62,451 | 62,451 | - | - | Stock Option (Right to Buy) | |
| Brian M. Culley | Director, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2013 | 907,300 | 907,300 | - | - | Employee Stock Option (Right to Buy) | |
| David A. Ramsay | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2013 | 62,451 | 62,451 | - | - | Stock Option (Right to Buy) | |
| Patrick L. Keran | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2013 | 907,300 | 907,300 | - | - | Employee Stock Option (Right to Buy) | |
| Santosh Vetticaden | Chief Medical Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2013 | 125,000 | 125,000 | - | - | Employee Stock Option (Right to Buy) | |
| Brandi L. Roberts | Chief Financial Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2013 | 301,250 | 301,250 | - | - | Employee Stock Option (Right to Buy) | |
| Gregory D. Gorgas | Senior VP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2013 | 292,500 | 292,500 | - | - | Employee Stock Option (Right to Buy) | |
| R. Martin Emanuele | Senior VP, Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2013 | 52,543 | 294,598 | - | - | Common Stock | |
| Brian M. Culley | Director, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2013 | 138,650 | 138,650 | - | - | Employee Stock Option (Right to Buy) | |
| Patrick L. Keran | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2013 | 138,650 | 138,650 | - | - | Employee Stock Option (Right to Buy) | |
| Brandi L. Roberts | Chief Financial Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2013 | 75,750 | 75,750 | - | - | Employee Stock Option (Right to Buy) | |
| Gregory D. Gorgas | Senior VP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2013 | 58,250 | 58,250 | - | - | Employee Stock Option (Right to Buy) | |
| R. Martin Emanuele | Senior VP, Development | Other type of transaction at price $ 0.00 per share. | 13 Dec 2012 | 305,608 | 242,055 | - | - | Common Stock | |
| Ted W. Love | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Sep 2012 | 18,895 | 18,895 | - | - | Stock Option (Right to Buy) | |
| Ted W. Love | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Sep 2012 | 14,171 | 14,171 | - | - | Stock Option (Right to Buy) | |
| Santosh Vetticaden | Chief Medical Officer & SVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Sep 2012 | 600,000 | 600,000 | - | - | Employee Stock Option (Right to Buy) | |
| Jack Lief | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jul 2012 | 27,310 | 27,310 | - | - | Stock Option (Right to Buy) | |
| Lewis J. Shuster | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jul 2012 | 27,310 | 27,310 | - | - | Stock Option (Right to Buy) | |
| David A. Ramsay | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jul 2012 | 27,310 | 27,310 | - | - | Stock Option (Right to Buy) | |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 May 2012 | 50,000 | 100,000 | - | - | Common Stock | |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 09 May 2012 | 10,000 | 10,000 | - | - | Common Stock | |
| David A. Ramsay | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 09 May 2012 | 40,000 | 50,000 | - | - | Common Stock | |
| Brian M. Culley | Director, CEO and Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Mar 2012 | 20,500 | 34,500 | - | - | Common Stock | |
| Brian M. Culley | Director, CEO and Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 13 Mar 2012 | 14,000 | 14,000 | - | - | Common Stock | |
| R. Martin Emanuele | Senior VP, Development | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 Dec 2011 | 41,000 | 547,663 | - | - | Common Stock | |
| Brian M. Culley | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2011 | 425,000 | 425,000 | - | - | Employee Stock Option (Right to Buy) | |
| Patrick L. Keran | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2011 | 425,000 | 425,000 | - | - | Employee Stock Option (Right to Buy) | |
| Brandi L. Roberts | Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2011 | 140,000 | 140,000 | - | - | Employee Stock Option (Right to Buy) | |
| Gregory D. Gorgas | Senior VP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2011 | 160,000 | 160,000 | - | - | Employee Stock Option (Right to Buy) | |
| Gregory D. Gorgas | Senior VP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jul 2011 | 100,000 | 100,000 | - | - | Employee Stock Option (Right to Buy) | |
| Brian M. Culley | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jul 2011 | 250,000 | 250,000 | - | - | Employee Stock Option (Right to Buy) | |
| Patrick L. Keran | President and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jul 2011 | 250,000 | 250,000 | - | - | Employee Stock Option (Right to Buy) | |
| Jack Lief | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2011 | 15,139 | 15,139 | - | - | Stock Option (Right to Buy) | |
| Lewis J. Shuster | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2011 | 10,480 | 10,480 | - | - | Stock Option (Right to Buy) | |
| Lewis J. Shuster | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2011 | 10,480 | 10,480 | - | - | Stock Option (Right to Buy) | |
| Lewis J. Shuster | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2011 | 1,746 | 1,746 | - | - | Stock Option (Right to Buy) | |
| David A. Ramsay | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2011 | 10,480 | 10,480 | - | - | Stock Option (Right to Buy) | |
| David A. Ramsay | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2011 | 10,480 | 10,480 | - | - | Stock Option (Right to Buy) | |
| Brandi L. Roberts | Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2011 | 85,000 | 85,000 | - | - | Employee Stock Option (Right to Buy) | |
| Brian M. Culley | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Jun 2011 | 5,000 | 0 | - | - | COMMON STOCK | |
| Brian M. Culley | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2011 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Patrick L. Keran | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2011 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Jack Lief | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2010 | 4,000 | 4,000 | - | - | Stock Option (Right to Buy) | |
| Michael M. Goldberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2010 | 4,000 | 4,000 | - | - | Stock Option (Right to Buy) | |
| Mark J. Pykett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2010 | 4,000 | 4,000 | - | - | Stock Option (Right to Buy) | |
| Eric K. Rowinsky | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2010 | 4,000 | 4,000 | - | - | Stock Option (Right to Buy) | |
| Odysseas D. Kostas | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2010 | 4,000 | 4,000 | - | - | Stock Option (Right to Buy) | |
| Brian M. Culley | Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 27 May 2010 | 5,000 | 5,000 | - | - | Common Stock | |
| Jack Lief | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 100,000 | 100,000 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Jack Lief | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 100,000 | 100,000 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Michael M. Goldberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 100,000 | 100,000 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Michael M. Goldberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 100,000 | 100,000 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Mark J. Pykett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 100,000 | 100,000 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Mark J. Pykett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 100,000 | 100,000 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Brian M. Culley | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 1,600,000 | 1,600,000 | - | - | Stock Option (Right to Buy) | |
| Eric K. Rowinsky | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 100,000 | 100,000 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Eric K. Rowinsky | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 100,000 | 100,000 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Patrick L. Keran | President, COO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 1,600,000 | 1,600,000 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Odysseas D. Kostas | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 100,000 | 100,000 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Odysseas D. Kostas | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2010 | 33,332 | 33,332 | - | - | Non-qualified Stock Option (Right to Buy) | |
| Brian M. Culley | SVP & Chief Business Officer | Sale or transfer of securities back to the company at price $ 0.00 per share. | 21 Jul 2009 | 1,200,000 | 0 | - | - | Restricted Stock Units | |
| Brian M. Culley | SVP & Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jul 2009 | 1,700,000 | 1,700,000 | - | - | Stock Option (Right to Buy) | |
| Patrick L. Keran | VP, Legal and General Counsel | Sale or transfer of securities back to the company at price $ 0.00 per share. | 21 Jul 2009 | 850,000 | 0 | - | - | Restricted Stock Units | |
| Patrick L. Keran | VP, Legal and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jul 2009 | 1,700,000 | 1,700,000 | - | - | Stock Option (Right to Buy) | |
| Brian M. Culley | SVP & Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2009 | 1,200,000 | 1,200,000 | - | - | Restricted Stock Units | |
| Patrick L. Keran | VP, Legal and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2009 | 850,000 | 850,000 | - | - | Restricted Stock Units | |
| Michele L. Yelmene | VP, Regulatory & QA | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2009 | 450,000 | 450,000 | - | - | Restricted Stock Units | |
| Mark E. Erwin | SVP, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2009 | 650,000 | 650,000 | - | - | Restricted Stock Units | |
| Jack Lief | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2008 | 50,000 | 50,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael M. Goldberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2008 | 50,000 | 50,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Mark J. Pykett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2008 | 50,000 | 50,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric K. Rowinsky | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2008 | 50,000 | 50,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Alexander J. Denner, | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2008 | 50,000 | 150,000 | - | - | OPTION TO PURCHASE COMMON STOCK | |
| Joan M. Robbins | CSO, Sr. VP | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 13 May 2008 | 5,000 | 5,000 | - | - | Common Stock | |
| Joan M. Robbins | CSO, Sr. VP | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 13 May 2008 | 5,000 | 10,000 | - | - | Common Stock | |
| Mark N.K. Bagnall | Director, CFO & Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Apr 2008 | 500,000 | 500,000 | - | - | Incentive Stock Option (right to buy) | |
| Joan M. Robbins | SVP & Chief Science Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2008 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Brian M. Culley | SVP & Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2008 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Patrick L. Keran | VP, Legal and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2008 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Joachim P.H. Schupp | VP, Medical Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2008 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Eric K. Rowinsky | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2008 | 50,000 | 50,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Alexander J. Denner, | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Mar 2008 | 50,000 | 100,000 | - | - | OPTION TO PURCHASE COMMON STOCK | |
| Evan Levine | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 08 Feb 2008 | 3,000 | 4,393,000 | - | - | Common Stock | |
| Evan Levine | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 08 Feb 2008 | 2,000 | 4,395,000 | - | - | Common Stock | |
| James A. Merritt | President & Chf Med Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Dec 2007 | 27,942 | 32,942 | - | - | Common Stock | |
| James A. Merritt | President & Chf Med Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Dec 2007 | 2,058 | 35,000 | - | - | Common Stock | |
| Evan Levine | Director, CEO & Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Dec 2007 | 50,000 | 50,000 | - | - | Common Stock | |
| Evan Levine | Director, CEO & Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Dec 2007 | 10,000 | 60,000 | - | - | Common Stock | |
| Joan M. Robbins | CSO, Sr. VP | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 07 Sep 2007 | 8,000 | 146,500 | - | - | COMMON STOCK | |
| Joan M. Robbins | CSO, Exec VP | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Aug 2007 | 8,000 | 154,500 | - | - | COMMON STOCK | |
| Jack Lief | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2007 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Michael M. Goldberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2007 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Mark N.K. Bagnall | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2007 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Mark J. Pykett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2007 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Alexander J. Denner, | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2007 | 50,000 | 50,000 | - | - | OPTION TO PURCHASE COMMON STOCK | |
| Joan M. Robbins | Senior VP and CS0 | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2007 | 75,000 | 75,000 | - | - | Stock Option (Right to Buy) | |
| Mark J. Cantwell | VP, Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2007 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| James A. Merritt | President & Chf Med Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2007 | 33,333 | 33,333 | - | - | Stock Option (Right to Buy) | |
| Brian M. Culley | SVP & Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2007 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Patrick L. Keran | VP, Legal & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2007 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Joachim P.H. Schupp | VP, Medical Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2007 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| M. Ross Johnson | None | 21 Dec 2006 | 502,528 | 0 | - | - | Common Stock Warrant (Right to Buy) | ||
| M. Ross Johnson | None | 21 Dec 2006 | 502,528 | 1,717,592 | - | - | Common Stock | ||
| M. Ross Johnson | None | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 21 Dec 2006 | 95,813 | 1,621,779 | - | - | Common Stock | |
| Gregory P. Hanson | Senior VP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2006 | 250,000 | 250,000 | - | - | Stock Option (Right to Buy) | |
| Michael M. Goldberg | None | 15 Oct 2006 | 6,000 | 0 | - | - | Warrant to Purchase Common Stock (Right to Buy) | ||
| Michael M. Goldberg | None | 15 Oct 2006 | 6,000 | 26,000 | - | - | Common Stock | ||
| Jack Lief | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2006 | 50,000 | 50,000 | - | - | Option to Purchase Common Stock | |
| James A. Merritt | President & Chf Med Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2006 | 300,000 | 300,000 | - | - | Option to Purchase Common Stock | |
| Patrick L. Keran | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Aug 2006 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Joachim P.H. Schupp | VP, Medical Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Aug 2006 | 100,000 | 100,000 | - | - | Option to Purchase Common Stock | |
| Evan Levine | Director, President & CEO | 28 Jun 2006 | 25,000 | 0 | - | - | Warrant To Purchase Common Stock | ||
| Evan Levine | Director, President & CEO | 28 Jun 2006 | 25,000 | 4,320,000 | - | - | Common Stock | ||
| Evan Levine | Director, President & CEO | 26 Jun 2006 | 25,000 | 4,295,000 | - | - | Common Stock | ||
| Evan Levine | Director, President & CEO | 26 Jun 2006 | 25,000 | 0 | - | - | Warrant To Purchase Common Stock | ||
| Evan Levine | Director, President & CEO | 23 Jun 2006 | 25,000 | 0 | - | - | Warrant To Purchase Common Stock | ||
| Evan Levine | Director, President & CEO | 23 Jun 2006 | 25,000 | 4,270,000 | - | - | Common Stock | ||
| Evan Levine | Director, President & CEO | 21 Jun 2006 | 25,000 | 4,245,000 | - | - | Common Stock | ||
| Evan Levine | Director, President & CEO | 21 Jun 2006 | 25,000 | 0 | - | - | Warrant To Purchase Common Stock | ||
| M. Ross Johnson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2006 | 50,000 | 50,000 | - | - | Option to Purchase Common Stock | |
| Michael M. Goldberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2006 | 50,000 | 50,000 | - | - | Option to Purchase Common Stock | |
| Keith A. Meister | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2006 | 50,000 | 50,000 | - | - | OPTION TO PURCHASE COMMON STOCK | |
| Mark N.K. Bagnall | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2006 | 50,000 | 50,000 | - | - | Option to Purchase Common Stock | |
| Mark J. Pykett | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2006 | 50,000 | 50,000 | - | - | Option to Purchase Common Stock | |
| Evan Levine | Director, President & CEO | 24 Apr 2006 | 25,601 | 0 | - | - | Warrant To Purchase Common Stock | ||
| Evan Levine | Director, President & CEO | 24 Apr 2006 | 25,601 | 4,220,000 | - | - | Common Stock | ||
| Joan M. Robbins | CSO, Exec. VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2006 | 100,000 | 100,000 | - | - | Option to Purchase Common Stock | |
| Carrie E. McQueen | CFO, Treas, Secy, VP Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2006 | 80,000 | 80,000 | - | - | Option to Purchase Common Stock | |
| Brian M. Culley | VP, Business Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2006 | 80,000 | 80,000 | - | - | Option to Purchase Common Stock | |
| Evan Levine | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 12 Sep 2005 | 1,000 | 4,193,399 | - | - | Common Stock | |
| Evan Levine | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 12 Sep 2005 | 4,600 | 4,188,799 | - | - | Common Stock | |
| Evan Levine | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 12 Sep 2005 | 1,100 | 4,187,699 | - | - | Common Stock | |
| Evan Levine | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 12 Sep 2005 | 19,599 | 4,168,100 | - | - | Common Stock | |
| Evan Levine | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 12 Sep 2005 | 28,100 | 4,140,000 | - | - | Common Stock | |
| Evan Levine | Director, President and CEO | 12 Sep 2005 | 54,399 | 4,194,399 | - | - | Common Stock | ||
| Evan Levine | Director, President and CEO | 12 Sep 2005 | 54,399 | 125,601 | - | - | Warrant to purchase common stock | ||
| Carrie E. McQueen | CFO, Treasurer, VP Finance | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 15 Jun 2005 | 5,000 | 25,000 | - | - | Common Stock | |
| Carrie E. McQueen | CFO, Treasurer, VP Finance | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 31 May 2005 | 5,000 | 20,000 | - | - | Common Stock | |
| Carrie E. McQueen | CFO, Treasurer, VP Finance | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 16 May 2005 | 5,000 | 15,000 | - | - | Common Stock | |
| Carrie E. McQueen | CFO, Treasurer, VP Finance | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 02 May 2005 | 5,000 | 10,000 | - | - | Common Stock |