8.8M XNAS Volume
XNAS 19 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| B. Scott Willoughby | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.00 per share. | 24 Feb 2025 | 1,434 | 696,217 (0%) | 0% | 1 | 1,434 | Common Stock |
| D. Gregory Davis | Head of Research & Technology | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.96 per share. | 24 Feb 2025 | 507 | 166,358 (0%) | 0% | 1.0 | 485 | Common Stock |
| Gregory D. Davis | Head of Research & Technology | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.00 per share. | 24 Feb 2025 | 705 | 166,865 (0%) | 0% | 1 | 705 | Common Stock |
| Dubois-Stringfellow Nathalie | SVP-CHIEF DEVELOPMENT OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.96 per share. | 24 Feb 2025 | 1,513 | 713,405 (0%) | 0% | 1.0 | 1,447 | Common Stock |
| Alexander Donald Macrae | Director, PRESIDENT, CEO AND DIRECTOR | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.96 per share. | 24 Feb 2025 | 10,663 | 2,077,848 (1%) | 0% | 1.0 | 10,195 | Common Stock |
| Donald Alexander Macrae | Director, PRESIDENT, CEO AND DIRECTOR | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 375,000 | 2,452,848 (2%) | 0% | 0 | Common Stock | |
| Davis D. Gregory | Head of Research & Technology | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 99,454 | 99,454 | - | - | Stock Option (Right to Buy) | |
| Duraibabu Prathyusha | SVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 560,000 | 560,000 | - | - | Stock Option (Right to Buy) | |
| Gregory D. Davis | Head of Research & Technology | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 49,726 | 216,084 (0%) | 0% | 0 | Common Stock | |
| Duraibabu Prathyusha | SVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 120,000 | 811,803 (0%) | 0% | 0 | Common Stock | |
| Dubois-Stringfellow Nathalie | SVP-CHIEF DEVELOPMENT OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 560,000 | 560,000 | - | - | Stock Option (Right to Buy) | |
| Macrae Alexander Donald | Director, PRESIDENT, CEO AND DIRECTOR | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 1,750,000 | 1,750,000 | - | - | Stock Option (Right to Buy) | |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.96 per share. | 24 Feb 2025 | 1,375 | 691,803 (0%) | 0% | 1.0 | 1,315 | Common Stock |
| B. Scott Willoughby | SVP, GEN. COUNSEL & SECRETARY | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 120,000 | 814,842 (0%) | 0% | 0 | Common Stock | |
| Nathalie Dubois-Stringfellow | SVP-CHIEF DEVELOPMENT OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 120,000 | 833,405 (0%) | 0% | 0 | Common Stock | |
| Willoughby Scott B. | SVP, GEN. COUNSEL & SECRETARY | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2025 | 560,000 | 560,000 | - | - | Stock Option (Right to Buy) | |
| Dubois-Stringfellow Nathalie | SVP-CHIEF DEVELOPMENT OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.00 per share. | 24 Feb 2025 | 1,792 | 714,918 (0%) | 0% | 1 | 1,792 | Common Stock |
| B. Scott Willoughby | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.96 per share. | 24 Feb 2025 | 1,375 | 694,842 (0%) | 0% | 1.0 | 1,315 | Common Stock |
| Alexander Macrae Donald | Director, PRESIDENT, CEO AND DIRECTOR | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.00 per share. | 24 Feb 2025 | 7,488 | 2,088,511 (1%) | 0% | 1 | 7,488 | Common Stock |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.00 per share. | 24 Feb 2025 | 1,792 | 693,178 (0%) | 0% | 1 | 1,792 | Common Stock |
| Alexander Donald Macrae | Director, PRESIDENT, CEO AND DIRECTOR | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.15 per share. | 22 Jan 2025 | 412,584 | 2,095,999 (1%) | 0% | 1.2 | 474,472 | Common Stock |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.15 per share. | 22 Jan 2025 | 129,242 | 694,970 (0%) | 0% | 1.1 | 148,628 | Common Stock |
| Scott B. Willoughby | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.15 per share. | 22 Jan 2025 | 129,549 | 697,651 (0%) | 0% | 1.1 | 148,981 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-CHIEF DEVELOPMENT OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.15 per share. | 22 Jan 2025 | 129,593 | 716,710 (0%) | 0% | 1.2 | 149,032 | Common Stock |
| Gregory D. Davis | Head of Research & Technology | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.15 per share. | 22 Jan 2025 | 30,456 | 167,570 (0%) | 0% | 1.1 | 35,024 | Common Stock |
| Alexander Donald Macrae | Director, PRESIDENT, CEO AND DIRECTOR | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.88 per share. | 24 Nov 2024 | 7,473 | 2,519,225 (2%) | 0% | 1.9 | 14,049 | Common Stock |
| Alexander Donald Macrae | Director, PRESIDENT, CEO AND DIRECTOR | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.94 per share. | 24 Nov 2024 | 10,642 | 2,508,583 (2%) | 0% | 1.9 | 20,645 | Common Stock |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.88 per share. | 24 Nov 2024 | 1,787 | 825,583 (0%) | 0% | 1.9 | 3,360 | Common Stock |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.94 per share. | 24 Nov 2024 | 1,371 | 824,212 (0%) | 0% | 1.9 | 2,660 | Common Stock |
| Scott B. Willoughby | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.88 per share. | 24 Nov 2024 | 1,430 | 828,571 (0%) | 0% | 1.9 | 2,688 | Common Stock |
| Scott B. Willoughby | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.94 per share. | 24 Nov 2024 | 1,371 | 827,200 (0%) | 0% | 1.9 | 2,660 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-CHIEF DEVELOPMENT OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.88 per share. | 24 Nov 2024 | 1,787 | 842,811 (0%) | 0% | 1.9 | 3,360 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-CHIEF DEVELOPMENT OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.94 per share. | 24 Nov 2024 | 1,508 | 841,303 (0%) | 0% | 1.9 | 2,926 | Common Stock |
| Gregory D. Davis | Head of Research & Technology | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.88 per share. | 24 Nov 2024 | 721 | 202,368 (0%) | 0% | 1.9 | 1,355 | Common Stock |
| Gregory D. Davis | Head of Research & Technology | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.94 per share. | 24 Nov 2024 | 505 | 201,863 (0%) | 0% | 1.9 | 980 | Common Stock |
| Alexander Donald Macrae | Director, PRESIDENT, CEO AND DIRECTOR | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.86 per share. | 24 Aug 2024 | 7,492 | 2,526,698 (2%) | 0% | 0.9 | 6,443 | Common Stock |
| Alexander Donald Macrae | Director, PRESIDENT, CEO AND DIRECTOR | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.86 per share. | 24 Aug 2024 | 5,261 | 2,534,190 (2%) | 0% | 0.9 | 4,524 | Common Stock |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.86 per share. | 24 Aug 2024 | 1,371 | 827,370 (0%) | 0% | 0.9 | 1,179 | Common Stock |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.86 per share. | 24 Aug 2024 | 1,787 | 828,741 (0%) | 0% | 0.9 | 1,537 | Common Stock |
| Scott B. Willoughby | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.86 per share. | 24 Aug 2024 | 1,371 | 830,001 (0%) | 0% | 0.9 | 1,179 | Common Stock |
| Scott B. Willoughby | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.86 per share. | 24 Aug 2024 | 1,430 | 831,372 (0%) | 0% | 0.9 | 1,230 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-CHIEF DEVELOPMENT OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.86 per share. | 24 Aug 2024 | 1,508 | 844,598 (0%) | 0% | 0.9 | 1,297 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-CHIEF DEVELOPMENT OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.86 per share. | 24 Aug 2024 | 1,787 | 846,106 (0%) | 0% | 0.9 | 1,537 | Common Stock |
| Amy Pooler | VP, HEAD OF RESEARCH | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.86 per share. | 24 Aug 2024 | 493 | 193,923 (0%) | 0% | 0.9 | 424 | Common Stock |
| Amy Pooler | VP, HEAD OF RESEARCH | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.86 per share. | 24 Aug 2024 | 703 | 194,416 (0%) | 0% | 0.9 | 605 | Common Stock |
| Scott B. Willoughby | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.98 per share. | 13 Aug 2024 | 892 | 832,802 (0%) | 0% | 1.0 | 870 | Common Stock |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.61 per share. | 11 Jun 2024 | 892 | 830,528 (0%) | 0% | 0.6 | 542 | Common Stock |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 25,000 | 87,600 (0%) | 0% | 0 | Common Stock | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 25,000 | 74,600 (0%) | 0% | 0 | Common Stock | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 25,000 | 57,650 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Horn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 25,000 | 74,600 (0%) | 0% | 0 | Common Stock | |
| Kenneth J. Hillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 25,000 | 74,600 (0%) | 0% | 0 | Common Stock | |
| Kenneth J. Hillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 25,000 | 77,100 (0%) | 0% | 0 | Common Stock | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| John H. Markels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 25,000 | 71,384 (0%) | 0% | 0 | Common Stock | |
| John H. Markels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Courtney Beers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 25,000 | 57,650 (0%) | 0% | 0 | Common Stock | |
| Courtney Beers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2024 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Donald Macrae | Director, PRESIDENT, CEO AND DIRECTOR | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.60 per share. | 24 May 2024 | 5,261 | 2,546,943 (2%) | 0% | 0.6 | 3,157 | Common Stock |
| Alexander Donald Macrae | Director, PRESIDENT, CEO AND DIRECTOR | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.60 per share. | 24 May 2024 | 7,492 | 2,539,451 (2%) | 0% | 0.6 | 4,495 | Common Stock |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.60 per share. | 24 May 2024 | 1,371 | 831,420 (0%) | 0% | 0.6 | 823 | Common Stock |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.60 per share. | 24 May 2024 | 1,787 | 832,791 (0%) | 0% | 0.6 | 1,072 | Common Stock |
| Scott B. Willoughby | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.60 per share. | 24 May 2024 | 1,400 | 835,030 (0%) | 0% | 0.6 | 840 | Common Stock |
| Scott B. Willoughby | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.60 per share. | 24 May 2024 | 1,336 | 833,694 (0%) | 0% | 0.6 | 802 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-CHIEF DEVELOPMENT OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.60 per share. | 24 May 2024 | 1,787 | 844,401 (0%) | 0% | 0.6 | 1,072 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-CHIEF DEVELOPMENT OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.60 per share. | 24 May 2024 | 1,508 | 842,893 (0%) | 0% | 0.6 | 905 | Common Stock |
| Amy Pooler | VP, HEAD OF RESEARCH | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.60 per share. | 24 May 2024 | 702 | 195,612 (0%) | 0% | 0.6 | 421 | Common Stock |
| Amy Pooler | VP, HEAD OF RESEARCH | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.60 per share. | 24 May 2024 | 493 | 195,119 (0%) | 0% | 0.6 | 296 | Common Stock |
| Amy Pooler | VP, HEAD OF RESEARCH | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.13 per share. | 24 Feb 2024 | 2,459 | 196,314 (0%) | 0% | 1.1 | 2,779 | Common Stock |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.13 per share. | 24 Feb 2024 | 5,474 | 838,031 (0%) | 0% | 1.1 | 6,186 | Common Stock |
| Prathyusha Duraibabu | SVP, CHIEF FINANCIAL OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.13 per share. | 24 Feb 2024 | 3,453 | 834,578 (0%) | 0% | 1.1 | 3,902 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-CHIEF DEVELOPMENT OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.13 per share. | 24 Feb 2024 | 5,010 | 846,188 (0%) | 0% | 1.1 | 5,661 | Common Stock |
| B. Scott Willoughby | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.13 per share. | 24 Feb 2024 | 3,453 | 836,430 (0%) | 0% | 1.1 | 3,902 | Common Stock |
| B. Willoughby Scott | SVP, GEN. COUNSEL & SECRETARY | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.13 per share. | 24 Feb 2024 | 4,379 | 839,883 (0%) | 0% | 1.1 | 4,948 | Common Stock |
| Donald Macrae Alexander | Director, PRESIDENT, CEO AND DIRECTOR | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.13 per share. | 24 Feb 2024 | 16,115 | 2,576,361 (2%) | 0% | 1.1 | 18,210 | Common Stock |
| Amy Pooler | VP, HEAD OF RESEARCH | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.13 per share. | 24 Feb 2024 | 2,209 | 198,773 (0%) | 0% | 1.1 | 2,496 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-CHIEF DEVELOPMENT OFFICER | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.13 per share. | 24 Feb 2024 | 5,474 | 851,198 (0%) | 0% | 1.1 | 6,186 | Common Stock |
| Donald Macrae Alexander | Director, PRESIDENT, CEO AND DIRECTOR | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.13 per share. | 24 Feb 2024 | 24,157 | 2,552,204 (2%) | 0% | 1.1 | 27,297 | Common Stock |
| Pooler Amy | VP, HEAD OF RESEARCH | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2024 | 150,000 | 200,982 (0%) | 0% | 0 | Common Stock | |
| Alexander Donald Macrae | Director, PRESIDENT, CEO AND DIRECTOR | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2024 | 2,000,000 | 2,592,476 (2%) | 1% | 0 | Common Stock | |
| Dubois-Stringfellow Nathalie | SVP-CHIEF DEVELOPMENT OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2024 | 712,500 | 856,672 (0%) | 0% | 0 | Common Stock | |
| Duraibabu Prathyusha | SVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2024 | 712,500 | 843,505 (0%) | 0% | 0 | Common Stock | |
| Willoughby Scott B. | SVP, GEN. COUNSEL & SECRETARY | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2024 | 712,500 | 844,262 (0%) | 0% | 0 | Common Stock | |
| Alexander Donald Macrae | Director, President, CEO and Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.77 per share. | 25 Aug 2023 | 10,411 | 602,887 (0%) | 0% | 0.8 | 8,016 | Common Stock |
| Prathyusha Duraibabu | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.77 per share. | 25 Aug 2023 | 1,329 | 132,334 (0%) | 0% | 0.8 | 1,023 | Common Stock |
| David Mark McClung | EVP, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.77 per share. | 25 Aug 2023 | 1,925 | 214,396 (0%) | 0% | 0.8 | 1,482 | Common Stock |
| Jason D. Fontenot | SVP, Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.77 per share. | 25 Aug 2023 | 1,029 | 137,300 (0%) | 0% | 0.8 | 792 | Common Stock |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.77 per share. | 25 Aug 2023 | 1,329 | 128,091 (0%) | 0% | 0.8 | 1,023 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.77 per share. | 25 Aug 2023 | 1,462 | 140,634 (0%) | 0% | 0.8 | 1,126 | Common Stock |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.08 per share. | 13 Aug 2023 | 864 | 129,420 (0%) | 0% | 1.1 | 933 | Common Stock |
| David Mark McClung | EVP, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.19 per share. | 25 Jun 2023 | 11,528 | 211,321 (0%) | 0% | 1.2 | 13,718 | Common Stock |
| Prathyusha Duraibabu | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.19 per share. | 11 Jun 2023 | 864 | 133,663 (0%) | 0% | 1.2 | 1,028 | Common Stock |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 27,750 | 27,750 | - | - | Stock Option (Right to Buy) | |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 13,900 | 62,600 (0%) | 0% | 0 | Common Stock | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 27,750 | 27,750 | - | - | Stock Option (Right to Buy) | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 13,900 | 49,600 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Horn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 27,750 | 27,750 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 13,900 | 32,650 (0%) | 0% | 0 | Common Stock | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 13,900 | 49,600 (0%) | 0% | 0 | Common Stock | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 27,750 | 27,750 | - | - | Stock Option (Right to Buy) | |
| Kenneth J. Hillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 27,750 | 27,750 | - | - | Stock Option (Right to Buy) | |
| Kenneth J. Hillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 13,900 | 49,600 (0%) | 0% | 0 | Common Stock | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 13,900 | 52,100 (0%) | 0% | 0 | Common Stock | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 27,750 | 27,750 | - | - | Stock Option (Right to Buy) | |
| John H. Markels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 13,900 | 46,384 (0%) | 0% | 0 | Common Stock | |
| John H. Markels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 27,750 | 27,750 | - | - | Stock Option (Right to Buy) | |
| Courtney Beers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 13,900 | 32,650 (0%) | 0% | 0 | Common Stock | |
| Courtney Beers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2023 | 27,750 | 27,750 | - | - | Stock Option (Right to Buy) | |
| Alexander Donald Macrae | Director, President, CEO and Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.33 per share. | 25 May 2023 | 10,411 | 613,298 (0%) | 0% | 1.3 | 13,847 | Common Stock |
| Prathyusha Duraibabu | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.33 per share. | 25 May 2023 | 1,328 | 132,052 (0%) | 0% | 1.3 | 1,766 | Common Stock |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.33 per share. | 25 May 2023 | 1,750 | 171,467 (0%) | 0% | 1.3 | 2,328 | Common Stock |
| David Mark McClung | EVP, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.33 per share. | 25 May 2023 | 1,925 | 222,849 (0%) | 0% | 1.3 | 2,560 | Common Stock |
| Jason D. Fontenot | SVP, Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.33 per share. | 25 May 2023 | 1,029 | 138,329 (0%) | 0% | 1.3 | 1,369 | Common Stock |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.33 per share. | 25 May 2023 | 1,328 | 125,284 (0%) | 0% | 1.3 | 1,766 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.33 per share. | 25 May 2023 | 1,462 | 137,096 (0%) | 0% | 1.3 | 1,944 | Common Stock |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.65 per share. | 24 Apr 2023 | 3,977 | 126,612 (0%) | 0% | 1.6 | 6,562 | Common Stock |
| Prathyusha Duraibabu | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.66 per share. | 25 Mar 2023 | 345 | 133,380 (0%) | 0% | 1.7 | 573 | Common Stock |
| Alexander Donald Macrae | Director, President, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 157,300 | 678,476 (0%) | 0% | 0 | Common Stock | |
| Alexander Donald Macrae | Director, President, CEO and Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.66 per share. | 24 Feb 2023 | 54,767 | 623,709 (0%) | 0% | 2.7 | 145,680 | Common Stock |
| Alexander Donald Macrae | Director, President, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 734,050 | 734,050 | - | - | Stock Option (Right to Buy) | |
| Prathyusha Duraibabu | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 53,438 | 140,755 (0%) | 0% | 0 | Common Stock | |
| Prathyusha Duraibabu | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.66 per share. | 24 Feb 2023 | 7,030 | 133,725 (0%) | 0% | 2.7 | 18,700 | Common Stock |
| Prathyusha Duraibabu | SVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 249,375 | 249,375 | - | - | Stock Option (Right to Buy) | |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 210,000 | 210,000 | - | - | Stock Option (Right to Buy) | |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.66 per share. | 24 Feb 2023 | 15,618 | 173,217 (0%) | 0% | 2.7 | 41,544 | Common Stock |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 45,000 | 188,835 (0%) | 0% | 0 | Common Stock | |
| David Mark McClung | EVP, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.66 per share. | 24 Feb 2023 | 9,745 | 224,774 (0%) | 0% | 2.7 | 25,922 | Common Stock |
| David Mark McClung | EVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 56,250 | 234,519 (0%) | 0% | 0 | Common Stock | |
| David Mark McClung | EVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 262,500 | 262,500 | - | - | Stock Option (Right to Buy) | |
| Jason D. Fontenot | SVP, Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.66 per share. | 24 Feb 2023 | 6,559 | 139,358 (0%) | 0% | 2.7 | 17,447 | Common Stock |
| Jason D. Fontenot | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 42,750 | 145,917 (0%) | 0% | 0 | Common Stock | |
| Jason D. Fontenot | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 199,500 | 199,500 | - | - | Stock Option (Right to Buy) | |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 199,500 | 199,500 | - | - | Stock Option (Right to Buy) | |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 42,750 | 135,717 (0%) | 0% | 0 | Common Stock | |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.66 per share. | 24 Feb 2023 | 5,128 | 130,589 (0%) | 0% | 2.7 | 13,640 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 53,438 | 148,392 (0%) | 0% | 0 | Common Stock | |
| Nathalie Dubois-Stringfellow | SVP-Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.66 per share. | 24 Feb 2023 | 9,834 | 138,558 (0%) | 0% | 2.7 | 26,158 | Common Stock |
| Nathalie Dubois-Stringfellow | SVP-Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2023 | 249,375 | 249,375 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2022 | 37,500 | 37,500 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2022 | 18,750 | 18,750 (0%) | 0% | 0 | Common Stock | |
| Courtney Beers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2022 | 37,500 | 37,500 | - | - | Stock Option (Right to Buy) | |
| Courtney Beers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Dec 2022 | 18,750 | 18,750 (0%) | 0% | 0 | Common Stock | |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.33 per share. | 13 Aug 2022 | 864 | 92,966 (0%) | 0% | 6.3 | 5,469 | Common Stock |
| David Mark McClung | EVP, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.31 per share. | 25 Jun 2022 | 11,525 | 175,816 (0%) | 0% | 4.3 | 49,673 | Common Stock |
| Prathyusha Duraibabu | SVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 3.76 per share. | 11 Jun 2022 | 864 | 86,595 (0%) | 0% | 3.8 | 3,249 | Common Stock |
| John H. Markels | Director | Purchase of securities on an exchange or from another person at price $ 3.69 per share. | 03 Jun 2022 | 6,784 | 32,484 (0%) | 0% | 3.7 | 25,029 | Common Stock |
| H. Stewart Parker | Director | Purchase of securities on an exchange or from another person at price $ 3.60 per share. | 01 Jun 2022 | 5,000 | 48,700 (0%) | 0% | 3.6 | 17,996 | Common Stock |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.15 per share. | 29 Apr 2022 | 140 | 90,709 (0%) | 0% | 4.2 | 581 | Common Stock |
| Prathyusha Duraibabu | Vice President, Finance | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.83 per share. | 25 Apr 2022 | 662 | 86,772 (0%) | 0% | 4.8 | 3,197 | Common Stock |
| Jason D. Fontenot | SVP, Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.83 per share. | 25 Apr 2022 | 826 | 103,167 (0%) | 0% | 4.8 | 3,990 | Common Stock |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.70 per share. | 24 Apr 2022 | 3,976 | 90,849 (0%) | 0% | 4.7 | 18,687 | Common Stock |
| Prathyusha Duraibabu | Vice President, Finance | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.75 per share. | 25 Mar 2022 | 345 | 87,434 (0%) | 0% | 5.8 | 1,984 | Common Stock |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 12,500 | 43,700 (0%) | 0% | 0 | Common Stock | |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 12,500 | 35,700 (0%) | 0% | 0 | Common Stock | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Joseph S. Zakrzewski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Joseph S. Zakrzewski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 12,500 | 60,700 (0%) | 0% | 0 | Common Stock | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 12,500 | 35,700 (0%) | 0% | 0 | Common Stock | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 12,500 | 35,700 (0%) | 0% | 0 | Common Stock | |
| Kenneth J. Hillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Kenneth J. Hillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 12,500 | 35,700 (0%) | 0% | 0 | Common Stock | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 12,500 | 38,200 (0%) | 0% | 0 | Common Stock | |
| Alexander Donald Macrae | Director, President, CEO and Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.90 per share. | 25 Feb 2022 | 49,890 | 297,176 (0%) | 0% | 5.9 | 294,351 | Common Stock |
| Alexander Donald Macrae | Director, President, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 224,000 | 521,176 (0%) | 0% | 0 | Common Stock | |
| Alexander Donald Macrae | Director, President, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 604,800 | 604,800 | - | - | Stock Option (Right to Buy) | |
| Prathyusha Duraibabu | Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 41,000 | 87,779 (0%) | 0% | 0 | Common Stock | |
| Prathyusha Duraibabu | Vice President, Finance | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.90 per share. | 25 Feb 2022 | 3,474 | 46,779 (0%) | 0% | 5.9 | 20,497 | Common Stock |
| Prathyusha Duraibabu | Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 110,700 | 110,700 | - | - | Stock Option (Right to Buy) | |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.90 per share. | 25 Feb 2022 | 12,388 | 88,429 (0%) | 0% | 5.9 | 73,089 | Common Stock |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 54,000 | 142,429 (0%) | 0% | 0 | Common Stock | |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 145,800 | 145,800 | - | - | Stock Option (Right to Buy) | |
| John H. Markels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 12,500 | 25,700 (0%) | 0% | 0 | Common Stock | |
| John H. Markels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| David Mark McClung | EVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 59,400 | 184,984 (0%) | 0% | 0 | Common Stock | |
| David Mark McClung | EVP, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.90 per share. | 25 Feb 2022 | 4,610 | 125,584 (0%) | 0% | 5.9 | 27,199 | Common Stock |
| David Mark McClung | EVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 160,380 | 160,380 | - | - | Stock Option (Right to Buy) | |
| Robert J. Schott | SVP, Head of Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 41,000 | 75,537 (0%) | 0% | 0 | Common Stock | |
| Robert J. Schott | SVP, Head of Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 110,700 | 110,700 | - | - | Stock Option (Right to Buy) | |
| Jason D. Fontenot | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 121,770 | 121,770 | - | - | Stock Option (Right to Buy) | |
| Jason D. Fontenot | SVP, Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.90 per share. | 25 Feb 2022 | 6,248 | 58,893 (0%) | 0% | 5.9 | 36,863 | Common Stock |
| Jason D. Fontenot | SVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 45,100 | 103,993 (0%) | 0% | 0 | Common Stock | |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.90 per share. | 25 Feb 2022 | 1,566 | 53,825 (0%) | 0% | 5.9 | 9,239 | Common Stock |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 110,700 | 110,700 | - | - | Stock Option (Right to Buy) | |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 41,000 | 94,825 (0%) | 0% | 0 | Common Stock | |
| Robert J. Schott | SVP, Head of Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.76 per share. | 12 Feb 2022 | 5,463 | 34,537 (0%) | 0% | 5.8 | 31,467 | Common Stock |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.12 per share. | 29 Oct 2021 | 140 | 54,455 (0%) | 0% | 8.1 | 1,137 | Common Stock |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Aug 2021 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Scott B. Willoughby | SVP, Gen. Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Aug 2021 | 7,500 | 54,595 (0%) | 0% | 0 | Common Stock | |
| David Mark McClung | EVP, Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.02 per share. | 25 Jun 2021 | 11,525 | 129,294 (0%) | 0% | 12.0 | 138,531 | Common Stock |
| Prathyusha Duraibabu | SVP, CFO, PFO and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2021 | 7,500 | 49,827 (0%) | 0% | 0 | Common Stock | |
| Prathyusha Duraibabu | SVP, CFO, PFO and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2021 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Prathyusha Duraibabu | VP, PFO and PAO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.71 per share. | 25 Apr 2021 | 662 | 40,128 (0%) | 0% | 11.7 | 7,752 | Common Stock |
| Jason D. Fontenot | SVP, Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.71 per share. | 25 Apr 2021 | 811 | 62,496 (0%) | 0% | 11.7 | 9,497 | Common Stock |
| Prathyusha Duraibabu | VP, PFO and PAO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.27 per share. | 25 Mar 2021 | 345 | 40,790 (0%) | 0% | 12.3 | 4,233 | Common Stock |
| Gary H. Loeb | EVP, General Counsel & Sec. | Sale of securities on an exchange or to another person at price $ 13.17 per share. | 23 Mar 2021 | 543 | 83,238 (0%) | 0% | 13.2 | 7,152 | Common Stock |
| Gary H. Loeb | EVP, General Counsel & Sec. | Sale of securities on an exchange or to another person at price $ 13.18 per share. | 23 Mar 2021 | 5,000 | 83,781 (0%) | 0% | 13.2 | 65,901 | Common Stock |
| Gary H. Loeb | EVP, General Counsel & Sec. | Sale of securities on an exchange or to another person at price $ 13.10 per share. | 23 Mar 2021 | 11,981 | 88,781 (0%) | 0% | 13.1 | 156,989 | Common Stock |
| Gary H. Loeb | EVP, General Counsel & Sec. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Mar 2021 | 11,981 | 238,019 | - | - | Stock Option (Right-to-Buy) | |
| Gary H. Loeb | EVP, General Counsel & Sec. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.02 per share. | 23 Mar 2021 | 11,981 | 100,762 (0%) | 0% | 11.0 | 132,031 | Common Stock |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 16,400 | 16,400 | - | - | Stock Option (Right to Buy) | |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 8,200 | 31,200 (0%) | 0% | 0 | Common Stock | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 8,200 | 23,200 (0%) | 0% | 0 | Common Stock | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 16,400 | 16,400 | - | - | Stock Option (Right to Buy) | |
| Joseph S. Zakrzewski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 8,200 | 48,200 (0%) | 0% | 0 | Common Stock | |
| Joseph S. Zakrzewski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 16,400 | 16,400 | - | - | Stock Option (Right to Buy) | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 16,400 | 16,400 | - | - | Stock Option (Right to Buy) | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 8,200 | 23,200 (0%) | 0% | 0 | Common Stock | |
| Gary H. Loeb | EVP, General Counsel & Sec. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.19 per share. | 25 Feb 2021 | 5,762 | 44,781 (0%) | 0% | 11.2 | 64,477 | Common Stock |
| Gary H. Loeb | EVP, General Counsel & Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 44,000 | 88,781 (0%) | 0% | 0 | Common Stock | |
| Gary H. Loeb | EVP, General Counsel & Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 88,000 | 88,000 | - | - | Stock Option (Right to Buy) | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 8,200 | 23,200 (0%) | 0% | 0 | Common Stock | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 16,400 | 16,400 | - | - | Stock Option (Right to Buy) | |
| Kenneth J. Hillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 8,200 | 23,200 (0%) | 0% | 0 | Common Stock | |
| Kenneth J. Hillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 16,400 | 16,400 | - | - | Stock Option (Right to Buy) | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 8,200 | 25,700 (0%) | 0% | 0 | Common Stock | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 16,400 | 16,400 | - | - | Stock Option (Right to Buy) | |
| Alexander Donald Macrae | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 138,375 | 347,066 (0%) | 0% | 0 | Common Stock | |
| Alexander Donald Macrae | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.19 per share. | 25 Feb 2021 | 35,311 | 208,691 (0%) | 0% | 11.2 | 395,130 | Common Stock |
| Alexander Donald Macrae | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 276,750 | 276,750 | - | - | Stock Option (Right to Buy) | |
| Prathyusha Duraibabu | VP, PFO and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 27,500 | 27,500 | - | - | Stock Option (Right to Buy) | |
| Prathyusha Duraibabu | VP, PFO and PAO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.19 per share. | 25 Feb 2021 | 1,863 | 27,385 (0%) | 0% | 11.2 | 20,847 | Common Stock |
| Prathyusha Duraibabu | VP, PFO and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 13,750 | 41,135 (0%) | 0% | 0 | Common Stock | |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 40,000 | 98,199 (0%) | 0% | 0 | Common Stock | |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.19 per share. | 25 Feb 2021 | 7,779 | 58,199 (0%) | 0% | 11.2 | 87,047 | Common Stock |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| John H. Markels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 8,200 | 13,200 (0%) | 0% | 0 | Common Stock | |
| John H. Markels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 16,400 | 16,400 | - | - | Stock Option (Right to Buy) | |
| David Mark McClung | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| David Mark McClung | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 40,000 | 140,000 (0%) | 0% | 0 | Common Stock | |
| Robert J. Schott | SVP, Head of Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2021 | 40,000 | 40,000 (0%) | 0% | 0 | Common Stock | |
| Robert J. Schott | SVP, Head of Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Feb 2021 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Donald Macrae | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.95 per share. | 24 Jan 2021 | 3,977 | 244,002 (0%) | 0% | 14.9 | 59,456 | Common Stock |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Sale of securities on an exchange or to another person at price $ 18.13 per share. | 24 Dec 2020 | 3,331 | 68,442 (0%) | 0% | 18.1 | 60,391 | Common Stock |
| Saira Ramasastry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2020 | 10,000 | 0 | - | - | Stock Option (Right-to-Buy) | |
| Saira Ramasastry | Director | Sale of securities on an exchange or to another person at price $ 13.27 per share. | 17 Dec 2020 | 10,000 | 15,000 (0%) | 0% | 13.3 | 132,747 | Common Stock |
| Saira Ramasastry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.99 per share. | 17 Dec 2020 | 10,000 | 25,000 (0%) | 0% | 6.0 | 59,900 | Common Stock |
| Sung H. Lee | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 9.77 per share. | 25 Nov 2020 | 5,042 | 88,708 (0%) | 0% | 9.8 | 49,260 | Common Stock |
| Kenneth J. Hillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2020 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Kenneth J. Hillan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2020 | 15,000 | 15,000 (0%) | 0% | 0 | Common Stock | |
| David Mark McClung | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2020 | 100,000 | 100,000 (0%) | 0% | 0 | Common Stock | |
| David Mark McClung | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2020 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Stephane Boissel | EVP, Corp. Strategy | Sale or transfer of securities back to the company at price $ 11.23 per share. | 04 Jun 2020 | 14,907 | 70,116 (0%) | 0% | 11.2 | 167,406 | Common Stock |
| Stephane Boissel | EVP, Corp. Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jun 2020 | 1 | 2 | - | - | Free Shares Put Option (right to sell to Issuer) | |
| Stephane Boissel | EVP, Corp. Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jun 2020 | 14,907 | 85,023 (0%) | 0% | - | Common Stock | |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 10,000 | 23,000 (0%) | 0% | 0 | Common Stock | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 10,000 | 15,000 (0%) | 0% | 0 | Common Stock | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Joseph S. Zakrzewski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Joseph S. Zakrzewski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 10,000 | 40,000 (0%) | 0% | 0 | Common Stock | |
| Stephen Dilly | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 10,000 | 15,000 (0%) | 0% | 0 | Common Stock | |
| Stephen Dilly | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 10,000 | 15,000 (0%) | 0% | 0 | Common Stock | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 10,000 | 15,000 (0%) | 0% | 0 | Common Stock | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 10,000 | 17,500 (0%) | 0% | 0 | Common Stock | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Stephane Boissel | EVP, Corp. Strategy | 09 May 2020 | 1 | 2 | - | - | Free Shares Call Options (obligation to sell to Issuer) | ||
| Stephane Boissel | EVP, Corp. Strategy | 09 May 2020 | 1 | 1 | - | - | Free Shares Call Options (obligation to sell to Issuer) | ||
| Prathyusha Duraibabu | VP Principal Acct. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.32 per share. | 25 Apr 2020 | 647 | 26,603 (0%) | 0% | 8.3 | 5,383 | Common Stock |
| Prathyusha Duraibabu | VP Principal Acct. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Mar 2020 | 3,000 | 27,250 (0%) | 0% | 0 | Common Stock | |
| Stephen Dilly | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Mar 2020 | 35,000 | 0 | - | - | Stock Option (Right-to-Buy) | |
| Stephen Dilly | Director | Sale of securities on an exchange or to another person at price $ 6.00 per share. | 19 Mar 2020 | 35,000 | 5,000 (0%) | 0% | 6 | 210,000 | Common Stock |
| Stephen Dilly | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.42 per share. | 19 Mar 2020 | 35,000 | 40,000 (0%) | 0% | 5.4 | 189,700 | Common Stock |
| H. Stewart Parker | Director | Purchase of securities on an exchange or from another person at price $ 5.20 per share. | 18 Mar 2020 | 3,000 | 13,000 (0%) | 0% | 5.2 | 15,585 | Common Stock |
| Joseph S. Zakrzewski | Director | Purchase of securities on an exchange or from another person at price $ 4.99 per share. | 17 Mar 2020 | 5,000 | 30,000 (0%) | 0% | 5.0 | 24,950 | Common Stock |
| Stephen Dilly | Director | Sale of securities on an exchange or to another person at price $ 6.02 per share. | 16 Mar 2020 | 15,000 | 5,000 (0%) | 0% | 6.0 | 90,261 | Common Stock |
| Stephen Dilly | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2020 | 15,000 | 35,000 | - | - | Stock Option (Right-to-Buy) | |
| Stephen Dilly | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.42 per share. | 16 Mar 2020 | 15,000 | 20,000 (0%) | 0% | 5.4 | 81,300 | Common Stock |
| Joseph S. Zakrzewski | Director | Purchase of securities on an exchange or from another person at price $ 5.67 per share. | 12 Mar 2020 | 5,000 | 25,000 (0%) | 0% | 5.7 | 28,350 | Common Stock |
| Joseph S. Zakrzewski | Director | Purchase of securities on an exchange or from another person at price $ 6.31 per share. | 12 Mar 2020 | 15,000 | 20,000 (0%) | 0% | 6.3 | 94,650 | Common Stock |
| Gary Loeb | EVP, General Counsel & Sec. | 25 Feb 2020 | 100,000 | 100,000 | - | - | Stock Option (Right-to-Buy) | ||
| Gary Loeb | EVP, General Counsel & Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 50,000 | 50,000 (0%) | 0% | 0 | Common Stock | |
| Alexander Donald Macrae | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 168,750 | 247,979 (0%) | 0% | 0 | Common Stock | |
| Alexander Donald Macrae | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.80 per share. | 25 Feb 2020 | 7,264 | 79,229 (0%) | 0% | 6.8 | 49,395 | Common Stock |
| Alexander Donald Macrae | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 337,500 | 337,500 | - | - | Stock Option (Right-to-Buy) | |
| Stephane Boissel | EVP, Corp. Strategy | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 55,000 | 70,116 (0%) | 0% | 0 | Common Stock | |
| Stephane Boissel | EVP, Corp. Strategy | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.80 per share. | 25 Feb 2020 | 2,384 | 15,116 (0%) | 0% | 6.8 | 16,211 | Common Stock |
| Stephane Boissel | EVP, Corp. Strategy | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 110,000 | 110,000 | - | - | Stock Option (Right-to-Buy) | |
| Adrian Woolfson | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 50,000 | 50,000 (0%) | 0% | 0 | Common Stock | |
| Adrian Woolfson | EVP Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 100,000 | 100,000 | - | - | Stock Option (Right-to-Buy) | |
| Prathyusha Duraibabu | VP Principal Acct. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 33,000 | 33,000 | - | - | Stock Option (Right-to-Buy) | |
| Prathyusha Duraibabu | VP Principal Acct. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 16,500 | 24,250 (0%) | 0% | 0 | Common Stock | |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 110,000 | 110,000 | - | - | Stock Option (Right-to-Buy) | |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 55,000 | 69,128 (0%) | 0% | 0 | Common Stock | |
| Rolf Andrew Ramelmeier | EVP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.80 per share. | 25 Feb 2020 | 1,703 | 14,128 (0%) | 0% | 6.8 | 11,580 | Common Stock |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 100,500 | 100,500 | - | - | Stock Option (Right-to-Buy) | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2020 | 50,000 | 93,750 (0%) | 0% | 0 | Common Stock | |
| John Markels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2020 | 5,000 | 5,000 (0%) | 0% | 0 | Common Stock | |
| John Markels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2020 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Donald Macrae | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.50 per share. | 24 Jan 2020 | 4,283 | 86,493 (0%) | 0% | 7.5 | 32,123 | Common Stock |
| Stephane Boissel | EVP, Corp. Strategy | 31 Dec 2019 | 1 | 3 | - | - | Free Shares Call Options (obligation to sell to Issuer) | ||
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Nov 2019 | 262,000 | 262,000 | - | - | Stock Option (Right to Buy) | |
| Sung H. Lee | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Nov 2019 | 43,750 | 43,750 (0%) | 0% | 0 | Common Stock | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Nov 2019 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| James R. Meyers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Nov 2019 | 5,000 | 5,000 (0%) | 0% | 0 | Common Stock | |
| Gary H. Loeb | EVP, General Counsel & Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Aug 2019 | 250,000 | 250,000 | - | - | Stock Option (Right to Buy) | |
| Stephane Boissel | EVP, Corp. Strat. & Int. CFO | Sale or transfer of securities back to the company at price $ 11.23 per share. | 12 Aug 2019 | 11,137 | 17,500 (0%) | 0% | 11.2 | 125,069 | Common Stock |
| Stephane Boissel | EVP, Corp. Strat. & Int. CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2019 | 1 | 3 | - | - | Free Shares Put Option (right to sell to Issuer) | |
| Stephane Boissel | EVP, Corp. Strat. & Int. CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2019 | 11,137 | 28,637 (0%) | 0% | - | Common Stock | |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 2,500 | 10,000 (0%) | 0% | 0 | Common Stock | |
| H. Stewart Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Joseph S. Zakrzewski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 2,500 | 5,000 (0%) | 0% | 0 | Common Stock | |
| Joseph S. Zakrzewski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Stephen Dilly | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Stephen Dilly | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 2,500 | 5,000 (0%) | 0% | 0 | Common Stock | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 2,500 | 5,000 (0%) | 0% | 0 | Common Stock | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Robert F. Carey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 2,500 | 5,000 (0%) | 0% | 0 | Common Stock | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 2,500 | 7,500 (0%) | 0% | 0 | Common Stock | |
| Karen L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2019 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | EVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 15 May 2019 | 5,000 | 30,512 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Kathy Yi | EVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.00 per share. | 15 May 2019 | 5,000 | 25,512 (0%) | 0% | 10 | 50,000 | Common Stock |
| Kathy Yi | EVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2019 | 5,000 | 125,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | EVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2019 | 5,000 | 130,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | EVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.11 per share. | 15 Apr 2019 | 5,000 | 25,512 (0%) | 0% | 12.1 | 60,550 | Common Stock |
| Kathy Yi | EVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 15 Apr 2019 | 5,000 | 30,512 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Kathy Yi | EVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2019 | 5,000 | 135,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | EVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 15 Mar 2019 | 5,000 | 30,512 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Kathy Yi | EVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.00 per share. | 15 Mar 2019 | 5,000 | 25,512 (0%) | 0% | 10 | 50,000 | Common Stock |
| Kathy Yi | EVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.00 per share. | 01 Mar 2019 | 5,000 | 25,512 (0%) | 0% | 10 | 50,000 | Common Stock |
| Kathy Yi | EVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2019 | 5,000 | 140,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | EVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 01 Mar 2019 | 5,000 | 30,512 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Heather D. Turner | EVP, General Counsel & Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2019 | 115,500 | 115,500 | - | - | Stock Option (Right-to-Buy) | |
| Heather D. Turner | EVP, General Counsel & Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2019 | 19,250 | 19,250 (0%) | 0% | 0 | Common Stock | |
| Alexander Donald Macrae | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2019 | 63,250 | 90,776 (0%) | 0% | 0 | Common Stock | |
| Alexander Donald Macrae | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2019 | 379,500 | 379,500 | - | - | Stock Option (Right-to-Buy) | |
| Kathy Yi | EVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2019 | 19,250 | 25,512 (0%) | 0% | 0 | Common Stock | |
| Kathy Yi | EVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2019 | 115,500 | 115,500 | - | - | Stock Option (Right-to-Buy) | |
| Stephane Boissel | EVP, Corporate Strategy | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2019 | 105,000 | 105,000 | - | - | Stock Option (Right-to-Buy) | |
| Stephane Boissel | EVP, Corporate Strategy | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2019 | 17,500 | 17,500 (0%) | 0% | 0 | Common Stock | |
| Adrian Woolfson | EVP, Research and Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2019 | 250,000 | 250,000 | - | - | Stock Option (Right-to-Buy) | |
| Alexander Donald Macrae | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.10 per share. | 24 Jan 2019 | 3,974 | 27,526 (0%) | 0% | 11.1 | 44,111 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.10 per share. | 24 Jan 2019 | 834 | 11,291 (0%) | 0% | 11.1 | 9,257 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.10 per share. | 24 Jan 2019 | 988 | 6,262 (0%) | 0% | 11.1 | 10,967 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2019 | 5,000 | 145,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 11.04 per share. | 15 Jan 2019 | 5,000 | 7,250 (0%) | 0% | 11.0 | 55,200 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 15 Jan 2019 | 5,000 | 12,250 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2019 | 5,000 | 130,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 07 Jan 2019 | 5,000 | 17,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 12.33 per share. | 07 Jan 2019 | 5,000 | 12,125 (0%) | 0% | 12.3 | 61,631 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 17 Dec 2018 | 5,000 | 12,250 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 11.44 per share. | 17 Dec 2018 | 5,000 | 7,250 (0%) | 0% | 11.4 | 57,200 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2018 | 5,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 06 Dec 2018 | 5,000 | 17,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 11.49 per share. | 06 Dec 2018 | 5,000 | 12,125 (0%) | 0% | 11.5 | 57,433 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2018 | 5,000 | 135,000 | - | - | Stock Option (Right to Buy) | |
| Stephane Boissel | EVP, Corp. Strat. & Int. CFO | Other type of transaction at price $ 0.00 per share. | 27 Nov 2018 | 4 | 4 | - | - | Free Shares Call Options (obligation to sell to Issuer) | |
| Stephane Boissel | EVP, Corp. Strat. & Int. CFO | Other type of transaction at price $ 0.00 per share. | 27 Nov 2018 | 4 | 4 | - | - | Free Shares Put Options (right to sell to Issuer) | |
| Stephane Boissel | EVP, Corporate Strategy | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Nov 2018 | 283,523 | 283,523 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2018 | 5,000 | 155,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.00 per share. | 15 Nov 2018 | 5,000 | 7,250 (0%) | 0% | 10 | 50,000 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 15 Nov 2018 | 5,000 | 12,250 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| H. Stewart Parker | None | Purchase of securities on an exchange or from another person at price $ 9.00 per share. | 14 Nov 2018 | 2,000 | 7,500 (0%) | 0% | 9.0 | 18,002 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 06 Nov 2018 | 5,000 | 17,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 13.73 per share. | 06 Nov 2018 | 5,000 | 12,125 (0%) | 0% | 13.7 | 68,650 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Nov 2018 | 5,000 | 140,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2018 | 5,000 | 160,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 15 Oct 2018 | 5,000 | 12,250 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 13.97 per share. | 15 Oct 2018 | 5,000 | 7,250 (0%) | 0% | 14.0 | 69,850 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 08 Oct 2018 | 5,000 | 15,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Oct 2018 | 5,000 | 145,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 14.55 per share. | 08 Oct 2018 | 5,000 | 10,125 (0%) | 0% | 14.6 | 72,774 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 17 Sep 2018 | 5,000 | 12,250 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 14.66 per share. | 17 Sep 2018 | 5,000 | 7,250 (0%) | 0% | 14.7 | 73,285 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Sep 2018 | 5,000 | 165,000 | - | - | Stock Option (Right to Buy) | |
| H. Stewart Parker | None | Purchase of securities on an exchange or from another person at price $ 13.52 per share. | 07 Sep 2018 | 2,000 | 5,500 (0%) | 0% | 13.5 | 27,040 | Common Stock |
| Roger A. Jeffs | None | Purchase of securities on an exchange or from another person at price $ 13.56 per share. | 07 Sep 2018 | 7,408 | 9,908 (0%) | 0% | 13.6 | 100,487 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 14.17 per share. | 06 Sep 2018 | 5,000 | 10,125 (0%) | 0% | 14.2 | 70,845 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Sep 2018 | 5,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 06 Sep 2018 | 5,000 | 15,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 16 Aug 2018 | 5,000 | 12,250 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 15.39 per share. | 16 Aug 2018 | 5,000 | 7,250 (0%) | 0% | 15.4 | 76,952 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2018 | 5,000 | 170,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 06 Aug 2018 | 5,000 | 15,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 13.45 per share. | 06 Aug 2018 | 5,000 | 10,125 (0%) | 0% | 13.5 | 67,250 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2018 | 5,000 | 155,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 16 Jul 2018 | 5,000 | 12,250 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 14.77 per share. | 16 Jul 2018 | 5,000 | 7,250 (0%) | 0% | 14.8 | 73,860 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2018 | 5,000 | 175,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2018 | 5,000 | 160,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 06 Jul 2018 | 5,000 | 15,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 15.80 per share. | 06 Jul 2018 | 5,000 | 10,125 (0%) | 0% | 15.8 | 78,975 | Common Stock |
| Karen L. Smith | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2018 | 5,000 | 5,000 (0%) | 0% | 0 | Common Stock | |
| Karen L. Smith | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2018 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 15 Jun 2018 | 5,000 | 12,250 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jun 2018 | 5,000 | 180,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 15.67 per share. | 15 Jun 2018 | 5,000 | 7,250 (0%) | 0% | 15.7 | 78,365 | Common Stock |
| H. Stewart Parker | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 2,500 | 3,500 (0%) | 0% | 0 | Common Stock | |
| H. Stewart Parker | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Joseph S. Zakrzewski | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 2,500 | 2,500 (0%) | 0% | 0 | Common Stock | |
| Joseph S. Zakrzewski | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Roger A. Jeffs | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Roger A. Jeffs | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 2,500 | 2,500 (0%) | 0% | 0 | Common Stock | |
| Steven J. Mento | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Steven J. Mento | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 2,500 | 14,332 (0%) | 0% | 0 | Common Stock | |
| Stephen Dilly | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 2,500 | 2,500 (0%) | 0% | 0 | Common Stock | |
| Stephen Dilly | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 2,500 | 2,500 (0%) | 0% | 0 | Common Stock | |
| Robert F. Carey | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Robert F. Carey | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2018 | 2,500 | 2,500 (0%) | 0% | 0 | Common Stock | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2018 | 5,000 | 165,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 16.67 per share. | 06 Jun 2018 | 5,000 | 10,125 (0%) | 0% | 16.7 | 83,350 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 06 Jun 2018 | 5,000 | 15,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2018 | 5,000 | 185,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 15 May 2018 | 5,000 | 12,250 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 15.38 per share. | 15 May 2018 | 5,000 | 7,250 (0%) | 0% | 15.4 | 76,920 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 May 2018 | 5,000 | 170,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 07 May 2018 | 5,000 | 15,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 16.36 per share. | 07 May 2018 | 5,000 | 10,125 (0%) | 0% | 16.4 | 81,814 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Apr 2018 | 5,000 | 190,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.83 per share. | 16 Apr 2018 | 5,000 | 7,250 (0%) | 0% | 19.8 | 99,144 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 16 Apr 2018 | 5,000 | 12,250 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Apr 2018 | 8,163 | 3,750 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.07 per share. | 13 Apr 2018 | 8,163 | 22,788 (0%) | 0% | 14.1 | 114,853 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 13 Apr 2018 | 8,163 | 14,625 (0%) | 0% | 20 | 163,260 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 17.41 per share. | 06 Apr 2018 | 5,000 | 8,125 (0%) | 0% | 17.4 | 87,065 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 06 Apr 2018 | 5,000 | 13,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Apr 2018 | 5,000 | 175,000 | - | - | Stock Option (Right to Buy) | |
| Steven J. Mento | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Apr 2018 | 10,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Steven J. Mento | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.77 per share. | 02 Apr 2018 | 10,000 | 19,047 (0%) | 0% | 7.8 | 77,700 | Common Stock |
| Steven J. Mento | None | Sale of securities on an exchange or to another person at price $ 18.39 per share. | 02 Apr 2018 | 7,115 | 11,932 (0%) | 0% | 18.4 | 130,868 | Common Stock |
| Steven J. Mento | None | Sale of securities on an exchange or to another person at price $ 18.90 per share. | 02 Apr 2018 | 100 | 11,832 (0%) | 0% | 18.9 | 1,890 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Apr 2018 | 1,563 | 53,125 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Apr 2018 | 715 | 16,605 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.41 per share. | 02 Apr 2018 | 715 | 15,340 (0%) | 0% | 9.4 | 6,728 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Sale of securities on an exchange or to another person at price $ 18.30 per share. | 02 Apr 2018 | 2,278 | 14,625 (0%) | 0% | 18.3 | 41,684 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.50 per share. | 02 Apr 2018 | 1,563 | 16,903 (0%) | 0% | 3.5 | 5,471 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2018 | 5,000 | 195,000 | - | - | Stock Option (Right to Buy) | |
| Kathy Yi | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 25.56 per share. | 15 Mar 2018 | 5,000 | 7,250 (0%) | 0% | 25.6 | 127,812 | Common Stock |
| Kathy Yi | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.55 per share. | 15 Mar 2018 | 5,000 | 12,250 (0%) | 0% | 4.6 | 22,750 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2018 | 5,000 | 180,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 06 Mar 2018 | 5,000 | 13,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.78 per share. | 06 Mar 2018 | 5,000 | 8,125 (0%) | 0% | 24.8 | 123,878 | Common Stock |
| Steven J. Mento | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 5,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Steven J. Mento | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share. | 01 Mar 2018 | 5,000 | 8,480 (0%) | 0% | 6.4 | 32,050 | Common Stock |
| Steven J. Mento | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.03 per share. | 01 Mar 2018 | 10,000 | 18,480 (0%) | 0% | 5.0 | 50,300 | Common Stock |
| Steven J. Mento | None | Sale of securities on an exchange or to another person at price $ 23.27 per share. | 01 Mar 2018 | 9,433 | 9,047 (0%) | 0% | 23.3 | 219,546 | Common Stock |
| Steven J. Mento | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 10,000 | 0 | - | - | StockOption (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Sale of securities on an exchange or to another person at price $ 23.06 per share. | 01 Mar 2018 | 15,000 | 14,625 (0%) | 0% | 23.1 | 345,861 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.07 per share. | 01 Mar 2018 | 8,087 | 24,313 (0%) | 0% | 14.1 | 113,784 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.41 per share. | 01 Mar 2018 | 1,430 | 16,226 (0%) | 0% | 9.4 | 13,456 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.12 per share. | 01 Mar 2018 | 171 | 14,796 (0%) | 0% | 12.1 | 2,073 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 171 | 0 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 8,087 | 11,913 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 1,430 | 17,320 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2018 | 5,312 | 54,688 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.50 per share. | 01 Mar 2018 | 5,312 | 29,625 (0%) | 0% | 3.5 | 18,592 | Common Stock |
| Heather D. Turner | SVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 200,000 | 200,000 | - | - | Stock Option (Right to Buy) | |
| Saira Ramasastry | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2018 | 9,450 | 0 | - | - | Stock Option (Right to Buy) | |
| Saira Ramasastry | None | Sale of securities on an exchange or to another person at price $ 24.88 per share. | 26 Feb 2018 | 9,450 | 0 (0%) | 0% | 24.9 | 235,080 | Common Stock |
| Saira Ramasastry | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.03 per share. | 26 Feb 2018 | 9,450 | 9,450 (0%) | 0% | 5.0 | 47,534 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2018 | 5,000 | 185,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.49 per share. | 06 Feb 2018 | 5,000 | 8,125 (0%) | 0% | 18.5 | 92,436 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 06 Feb 2018 | 5,000 | 13,125 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Steven J. Mento | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.41 per share. | 01 Feb 2018 | 5,000 | 5,000 (0%) | 0% | 6.4 | 32,050 | Common Stock |
| Steven J. Mento | None | Sale of securities on an exchange or to another person at price $ 20.59 per share. | 01 Feb 2018 | 11,520 | 3,480 (0%) | 0% | 20.6 | 237,159 | Common Stock |
| Steven J. Mento | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2018 | 10,000 | 0 | - | - | StockOption (Right to Buy) | |
| Steven J. Mento | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2018 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Steven J. Mento | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.17 per share. | 01 Feb 2018 | 10,000 | 15,000 (0%) | 0% | 10.2 | 101,700 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Sale of securities on an exchange or to another person at price $ 20.59 per share. | 01 Feb 2018 | 15,000 | 14,625 (0%) | 0% | 20.6 | 308,855 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2018 | 15,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.50 per share. | 01 Feb 2018 | 15,000 | 29,625 (0%) | 0% | 3.5 | 52,500 | Common Stock |
| Alexander Donald Macrae | Director, President, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 189,000 | 189,000 | - | - | Stock Option (Right to Buy) | |
| Alexander Donald Macrae | Director, President, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 31,500 | 31,500 (0%) | 0% | 0 | Common Stock | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 50,250 | 50,250 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 8,375 | 14,625 (0%) | 0% | 0 | Common Stock | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 36,750 | 36,750 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 6,125 | 8,125 (0%) | 0% | 0 | Common Stock | |
| Kathy Yi | SVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 7,250 | 7,250 (0%) | 0% | 0 | Common Stock | |
| Kathy Yi | SVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 43,500 | 43,500 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 08 Jan 2018 | 5,000 | 7,000 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jan 2018 | 5,000 | 190,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 17.11 per share. | 08 Jan 2018 | 5,000 | 2,000 (0%) | 0% | 17.1 | 85,545 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Sale of securities on an exchange or to another person at price $ 16.35 per share. | 02 Jan 2018 | 6,974 | 6,250 (0%) | 0% | 16.4 | 114,025 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 02 Jan 2018 | 8,026 | 6,250 (0%) | 0% | 18.0 | 144,869 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2018 | 782 | 18,750 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2018 | 209 | 3,959 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2018 | 8,026 | 171 | - | - | Stock Option (Right to Buy) | |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.41 per share. | 02 Jan 2018 | 782 | 13,015 (0%) | 0% | 9.4 | 7,359 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.87 per share. | 02 Jan 2018 | 209 | 13,224 (0%) | 0% | 8.9 | 1,854 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.12 per share. | 02 Jan 2018 | 8,026 | 14,276 (0%) | 0% | 12.1 | 97,275 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 15.85 per share. | 08 Dec 2017 | 1,252 | 12,233 (0%) | 0% | 15.8 | 19,844 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 16.90 per share. | 08 Dec 2017 | 2,348 | 13,485 (0%) | 0% | 16.9 | 39,681 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.20 per share. | 06 Dec 2017 | 5,000 | 5,000 (0%) | 0% | 3.2 | 16,000 | Common Stock |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2017 | 5,000 | 195,000 | - | - | Stock Option (Right to Buy) | |
| Edward R. Conner | Sr. VP & Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 16.24 per share. | 06 Dec 2017 | 5,000 | 0 (0%) | 0% | 16.2 | 81,200 | Common Stock |
| Curt A. Herberts | Sr.VP & Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.12 per share. | 04 Dec 2017 | 11,803 | 27,636 (0%) | 0% | 12.1 | 143,052 | Common Stock |