1.3M XNAS Volume
XNAS 19 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Margaret A. Horn | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 28,600 | 156,591 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Horn | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 100,100 | 100,100 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 128,100 | 128,100 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 36,600 | 296,345 (0%) | 0% | 0 | Common Stock | |
| Mark A. Goldsmith | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 97,400 | 453,302 (0%) | 0% | 0 | Common Stock | |
| Mark A. Goldsmith | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 341,100 | 0 | - | - | Stock Option (Right to Buy) | |
| Jack Anders | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 20,400 | 116,870 (0%) | 0% | 0 | Common Stock | |
| Jack Anders | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 71,400 | 71,400 | - | - | Stock Option (Right to Buy) | |
| Xiaolin Wang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 66,500 | 66,500 | - | - | Stock Option (Right to Buy) | |
| Xiaolin Wang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 19,000 | 105,039 (0%) | 0% | 0 | Common Stock | |
| Wei Lin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 20,800 | 91,651 (0%) | 0% | 0 | Common Stock | |
| Wei Lin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 72,800 | 72,800 | - | - | Stock Option (Right to Buy) | |
| Jeff Cislini | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 77,000 | 77,000 | - | - | Stock Option (Right to Buy) | |
| Jeff Cislini | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 22,000 | 61,222 (0%) | 0% | 0 | Common Stock | |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 40.50 per share. | 21 Jan 2025 | 2,406 | 39,222 (0%) | 0% | 40.5 | 97,443 | Common Stock |
| Goldsmith A. Mark | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2024 | 30,846 | 0 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.49 per share. | 18 Dec 2024 | 30,846 | 355,902 (0%) | 0% | 0.5 | 15,115 | Common Stock |
| A. Horn Margaret | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 45.40 per share. | 16 Dec 2024 | 4,329 | 127,991 (0%) | 0% | 45.4 | 196,553 | Common Stock |
| Goldsmith A. Mark | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 45.40 per share. | 16 Dec 2024 | 11,714 | 325,056 (0%) | 0% | 45.4 | 531,860 | Common Stock |
| M. Kelsey Stephen | See Remarks | Sale of securities on an exchange or to another person at price $ 45.40 per share. | 16 Dec 2024 | 4,663 | 259,745 (0%) | 0% | 45.4 | 211,718 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 45.40 per share. | 16 Dec 2024 | 1,599 | 41,628 (0%) | 0% | 45.4 | 72,601 | Common Stock |
| Jack Anders | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.40 per share. | 16 Dec 2024 | 2,635 | 96,470 (0%) | 0% | 45.4 | 119,639 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 46.00 per share. | 05 Dec 2024 | 760,869 | 760,869 (1%) | 1% | 46 | 34,999,974 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 46.00 per share. | 05 Dec 2024 | 543,478 | 2,096,612 (3%) | 0% | 46 | 24,999,988 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 55.13 per share. | 15 Nov 2024 | 2,554 | 43,080 (0%) | 0% | 55.1 | 140,811 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Nov 2024 | 16,666 | 6,666 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 59.45 per share. | 13 Nov 2024 | 2,888 | 264,408 (0%) | 0% | 59.5 | 171,694 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 58.49 per share. | 13 Nov 2024 | 13,778 | 267,296 (0%) | 0% | 58.5 | 805,815 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 13 Nov 2024 | 16,666 | 281,074 (0%) | 0% | 4.1 | 68,164 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 06 Nov 2024 | 6,000 | 45,634 (0%) | 0% | 60 | 360,000 | Common Stock |
| Jeff Cislini | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.57 per share. | 06 Nov 2024 | 6,000 | 51,634 (0%) | 0% | 36.6 | 219,420 | Common Stock |
| Jeff Cislini | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Nov 2024 | 6,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 01 Nov 2024 | 9,100 | 309,270 (0%) | 0% | 4.1 | 37,219 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 36,600 | 30,846 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 50,900 | 181,229 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 9,100 | 232,129 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.49 per share. | 01 Nov 2024 | 36,600 | 336,770 (0%) | 0% | 0.5 | 17,934 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 55.56 per share. | 01 Nov 2024 | 50,900 | 300,170 (0%) | 0% | 55.6 | 2,827,821 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 01 Nov 2024 | 50,900 | 351,070 (0%) | 0% | 4.1 | 208,181 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 55.02 per share. | 01 Nov 2024 | 5,000 | 20,424 (0%) | 0% | 55.0 | 275,105 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 55.03 per share. | 01 Nov 2024 | 5,000 | 20,424 (0%) | 0% | 55.0 | 275,134 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 55.02 per share. | 01 Nov 2024 | 9,100 | 300,170 (0%) | 0% | 55.0 | 500,714 | Common Stock |
| Sushil Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.84 per share. | 31 Oct 2024 | 5,000 | 24,948 (0%) | 0% | 24.8 | 124,200 | Common Stock |
| Sushil Patel | Director | Sale of securities on an exchange or to another person at price $ 54.14 per share. | 31 Oct 2024 | 5,000 | 19,948 (0%) | 0% | 54.1 | 270,715 | Common Stock |
| Sushil Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Oct 2024 | 5,000 | 13,400 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 14 Oct 2024 | 16,666 | 281,074 (0%) | 0% | 4.1 | 68,164 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2024 | 16,666 | 23,332 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 50.08 per share. | 14 Oct 2024 | 2,610 | 264,408 (0%) | 0% | 50.1 | 130,702 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 49.38 per share. | 14 Oct 2024 | 14,056 | 267,018 (0%) | 0% | 49.4 | 694,102 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 11 Oct 2024 | 5,369 | 182,320 (0%) | 0% | 4.1 | 21,959 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Oct 2024 | 5,369 | 97,382 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Oct 2024 | 44,631 | 0 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 50.34 per share. | 11 Oct 2024 | 50,000 | 132,320 (0%) | 0% | 50.3 | 2,517,055 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 11 Oct 2024 | 44,631 | 176,951 (0%) | 0% | 4.1 | 182,541 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 11 Oct 2024 | 30,000 | 330,170 (0%) | 0% | 4.1 | 122,700 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 50.36 per share. | 11 Oct 2024 | 30,000 | 300,170 (0%) | 0% | 50.4 | 1,510,773 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Oct 2024 | 30,000 | 241,229 | - | - | Stock Option (Right to Buy) | |
| Jack Anders | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.68 per share. | 11 Oct 2024 | 10,000 | 108,932 (0%) | 0% | 2.7 | 26,800 | Common Stock |
| Jack Anders | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Oct 2024 | 10,000 | 2,814 | - | - | Stock Option (Right to Buy) | |
| Jack Anders | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 50.30 per share. | 11 Oct 2024 | 10,000 | 98,932 (0%) | 0% | 50.3 | 502,979 | Common Stock |
| Jeff Cislini | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Oct 2024 | 6,000 | 36,000 | - | - | Stock Option (Right to Buy) | |
| Jeff Cislini | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.57 per share. | 11 Oct 2024 | 6,000 | 51,634 (0%) | 0% | 36.6 | 219,420 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 50.17 per share. | 11 Oct 2024 | 6,000 | 45,634 (0%) | 0% | 50.2 | 301,027 | Common Stock |
| Barbara L. Weber | Director | Sale of securities on an exchange or to another person at price $ 48.02 per share. | 08 Oct 2024 | 5,200 | 13,065 (0%) | 0% | 48.0 | 249,716 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 01 Oct 2024 | 10,000 | 310,170 (0%) | 0% | 4.1 | 40,900 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 10,000 | 271,229 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 45.46 per share. | 01 Oct 2024 | 2,022 | 300,170 (0%) | 0% | 45.5 | 91,913 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 44.80 per share. | 01 Oct 2024 | 7,978 | 302,192 (0%) | 0% | 44.8 | 357,409 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 44.19 per share. | 16 Sep 2024 | 4,331 | 132,320 (0%) | 0% | 44.2 | 191,367 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 44.19 per share. | 16 Sep 2024 | 4,665 | 264,408 (0%) | 0% | 44.2 | 206,124 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 44.19 per share. | 16 Sep 2024 | 11,715 | 300,170 (0%) | 0% | 44.2 | 517,631 | Common Stock |
| Jack Anders | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 44.19 per share. | 16 Sep 2024 | 2,244 | 98,932 (0%) | 0% | 44.2 | 99,152 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 44.19 per share. | 16 Sep 2024 | 1,454 | 45,634 (0%) | 0% | 44.2 | 64,245 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Sep 2024 | 16,667 | 39,998 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 43.64 per share. | 13 Sep 2024 | 10,701 | 269,073 (0%) | 0% | 43.6 | 467,045 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 42.75 per share. | 13 Sep 2024 | 5,966 | 279,774 (0%) | 0% | 42.7 | 255,042 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 13 Sep 2024 | 16,667 | 285,740 (0%) | 0% | 4.1 | 68,168 | Common Stock |
| Barbara L. Weber | Director | Sale or transfer of securities back to the company at price $ 44.83 per share. | 21 Aug 2024 | 1,808 | 18,265 (0%) | 0% | 44.8 | 81,053 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 42.98 per share. | 13 Aug 2024 | 16,667 | 269,073 (0%) | 0% | 43.0 | 716,389 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 13 Aug 2024 | 16,667 | 285,740 (0%) | 0% | 4.1 | 68,168 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2024 | 16,667 | 56,665 | - | - | Stock Option (Right to Buy) | |
| Frank Clyburn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2024 | 27,744 | 27,744 | - | - | Stock Option (Right to Buy) | |
| Frank Clyburn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2024 | 6,932 | 6,932 (0%) | 0% | 0 | Common Stock | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 01 Aug 2024 | 10,000 | 321,885 (0%) | 0% | 4.1 | 40,900 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 45.60 per share. | 01 Aug 2024 | 6,783 | 315,102 (0%) | 0% | 45.6 | 309,308 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 46.48 per share. | 01 Aug 2024 | 3,217 | 311,885 (0%) | 0% | 46.5 | 149,519 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 10,000 | 281,229 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 15 Jul 2024 | 16,667 | 285,740 (0%) | 0% | 4.1 | 68,168 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 16,667 | 73,332 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 48.06 per share. | 15 Jul 2024 | 3,879 | 269,073 (0%) | 0% | 48.1 | 186,420 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 47.02 per share. | 15 Jul 2024 | 3,800 | 272,952 (0%) | 0% | 47.0 | 178,683 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 46.08 per share. | 15 Jul 2024 | 5,760 | 276,752 (0%) | 0% | 46.1 | 265,406 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 44.94 per share. | 15 Jul 2024 | 2,128 | 282,512 (0%) | 0% | 44.9 | 95,622 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 43.99 per share. | 15 Jul 2024 | 1,100 | 284,640 (0%) | 0% | 44.0 | 48,384 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jul 2024 | 25,000 | 291,229 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 45.01 per share. | 12 Jul 2024 | 5,000 | 25,424 (0%) | 0% | 45.0 | 225,059 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 45.01 per share. | 12 Jul 2024 | 5,000 | 25,424 (0%) | 0% | 45.0 | 225,058 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 45.05 per share. | 12 Jul 2024 | 25,000 | 311,885 (0%) | 0% | 45.0 | 1,126,205 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 12 Jul 2024 | 25,000 | 336,885 (0%) | 0% | 4.1 | 102,250 | Common Stock |
| Sushil Patel | Director | Sale of securities on an exchange or to another person at price $ 44.00 per share. | 09 Jul 2024 | 2,155 | 19,948 (0%) | 0% | 44 | 94,820 | Common Stock |
| Sushil Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2024 | 2,155 | 32,490 | - | - | Stock Option (Right to Buy) | |
| Sushil Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.80 per share. | 09 Jul 2024 | 2,155 | 22,103 (0%) | 0% | 16.8 | 36,204 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 40.83 per share. | 09 Jul 2024 | 2,399 | 47,088 (0%) | 0% | 40.8 | 97,951 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 38.47 per share. | 26 Jun 2024 | 2,000 | 49,487 (0%) | 0% | 38.5 | 76,940 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 39.06 per share. | 24 Jun 2024 | 16,467 | 269,073 (0%) | 0% | 39.1 | 643,152 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 39.00 per share. | 24 Jun 2024 | 200 | 269,073 (0%) | 0% | 39 | 7,800 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 24 Jun 2024 | 200 | 269,273 (0%) | 0% | 4.1 | 818 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 200 | 106,466 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 16,467 | 89,999 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 24 Jun 2024 | 16,467 | 285,540 (0%) | 0% | 4.1 | 67,350 | Common Stock |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,800 | 2,336,294 (3%) | 0% | 0 | Common Stock | |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 16,700 | 16,700 | - | - | Stock Option (Right to Buy) | |
| Sandra J. Horning | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 16,700 | 16,700 | - | - | Stock Option (Right to Buy) | |
| Sandra J. Horning | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,800 | 95,287 (0%) | 0% | 0 | Common Stock | |
| Lorence H. Kim | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 16,700 | 16,700 | - | - | Stock Option (Right to Buy) | |
| Lorence H. Kim | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,800 | 70,500 (0%) | 0% | 0 | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,800 | 20,625 (0%) | 0% | 0 | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 16,700 | 16,700 | - | - | Stock Option (Right to Buy) | |
| Barbara L. Weber | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 16,700 | 16,700 | - | - | Stock Option (Right to Buy) | |
| Barbara L. Weber | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,800 | 20,625 (0%) | 0% | 0 | Common Stock | |
| Sushil Patel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 16,700 | 16,700 | - | - | Stock Option (Right to Buy) | |
| Sushil Patel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,800 | 20,500 (0%) | 0% | 0 | Common Stock | |
| Flavia Borellini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,800 | 22,434 (0%) | 0% | 0 | Common Stock | |
| Flavia Borellini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 16,700 | 16,700 | - | - | Stock Option (Right to Buy) | |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,248 | 2,335,742 (3%) | 0% | 0 | Common Stock | |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 15,955 | 15,955 | - | - | Stock Option (Right to Buy) | |
| Sandra J. Horning | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 2,945 | 93,432 (0%) | 0% | 0 | Common Stock | |
| Sandra J. Horning | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 10,248 | 10,248 | - | - | Stock Option (Right to Buy) | |
| Lorence H. Kim | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,248 | 69,948 (0%) | 0% | 0 | Common Stock | |
| Lorence H. Kim | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 15,955 | 15,955 | - | - | Stock Option (Right to Buy) | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,248 | 20,073 (0%) | 0% | 0 | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 15,955 | 15,955 | - | - | Stock Option (Right to Buy) | |
| Barbara L. Weber | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 15,955 | 15,955 | - | - | Stock Option (Right to Buy) | |
| Barbara L. Weber | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,248 | 20,073 (0%) | 0% | 0 | Common Stock | |
| Sushil Patel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 15,955 | 15,955 | - | - | Stock Option (Right to Buy) | |
| Sushil Patel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,248 | 19,948 (0%) | 0% | 0 | Common Stock | |
| Flavia Borellini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 15,955 | 15,955 | - | - | Stock Option (Right to Buy) | |
| Flavia Borellini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jun 2024 | 4,248 | 21,882 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 37.39 per share. | 17 Jun 2024 | 4,415 | 136,651 (0%) | 0% | 37.4 | 165,064 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 37.39 per share. | 17 Jun 2024 | 3,349 | 269,073 (0%) | 0% | 37.4 | 125,209 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 37.39 per share. | 17 Jun 2024 | 11,950 | 311,885 (0%) | 0% | 37.4 | 446,770 | Common Stock |
| Jack Anders | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 37.39 per share. | 17 Jun 2024 | 1,893 | 101,176 (0%) | 0% | 37.4 | 70,775 | Common Stock |
| Wei Lin | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 37.39 per share. | 17 Jun 2024 | 5,589 | 70,851 (0%) | 0% | 37.4 | 208,954 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 37.39 per share. | 17 Jun 2024 | 1,757 | 51,487 (0%) | 0% | 37.4 | 65,690 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 03 Jun 2024 | 7,500 | 329,822 (0%) | 0% | 4.1 | 30,675 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 7,500 | 316,229 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 40.93 per share. | 03 Jun 2024 | 901 | 322,322 (0%) | 0% | 40.9 | 36,881 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 39.99 per share. | 03 Jun 2024 | 5,699 | 323,223 (0%) | 0% | 40.0 | 227,880 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 39.09 per share. | 03 Jun 2024 | 900 | 328,922 (0%) | 0% | 39.1 | 35,182 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 39.51 per share. | 21 May 2024 | 800 | 52,874 (0%) | 0% | 39.5 | 31,605 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 38.67 per share. | 21 May 2024 | 700 | 53,674 (0%) | 0% | 38.7 | 27,066 | Common Stock |
| Jack Anders | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.68 per share. | 03 May 2024 | 10,000 | 111,959 (0%) | 0% | 2.7 | 26,800 | Common Stock |
| Jack Anders | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 40.03 per share. | 03 May 2024 | 10,000 | 101,959 (0%) | 0% | 40.0 | 400,260 | Common Stock |
| Jack Anders | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2024 | 10,000 | 12,814 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 35.33 per share. | 10 Apr 2024 | 5,000 | 30,424 (0%) | 0% | 35.3 | 176,659 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 35.34 per share. | 10 Apr 2024 | 5,000 | 30,424 (0%) | 0% | 35.3 | 176,687 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 35.48 per share. | 10 Apr 2024 | 7,500 | 452,879 (0%) | 0% | 35.5 | 266,122 | Common Stock |
| Sushil Patel | Director | Sale of securities on an exchange or to another person at price $ 37.00 per share. | 10 Apr 2024 | 2,155 | 15,700 (0%) | 0% | 37 | 79,735 | Common Stock |
| Sushil Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Apr 2024 | 2,155 | 34,645 | - | - | Stock Option (Right to Buy) | |
| Sushil Patel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.80 per share. | 10 Apr 2024 | 2,155 | 17,855 (0%) | 0% | 16.8 | 36,204 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 31.52 per share. | 27 Mar 2024 | 800 | 54,374 (0%) | 0% | 31.5 | 25,212 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 30.38 per share. | 27 Mar 2024 | 700 | 55,174 (0%) | 0% | 30.4 | 21,269 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 31.58 per share. | 18 Mar 2024 | 2,914 | 139,553 (0%) | 0% | 31.6 | 92,033 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 31.58 per share. | 18 Mar 2024 | 2,123 | 270,909 (0%) | 0% | 31.6 | 67,051 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 31.58 per share. | 18 Mar 2024 | 5,788 | 460,379 (0%) | 0% | 31.6 | 182,804 | Common Stock |
| Jack Anders | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 31.58 per share. | 18 Mar 2024 | 1,261 | 101,959 (0%) | 0% | 31.6 | 39,826 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 31.58 per share. | 18 Mar 2024 | 1,252 | 55,874 (0%) | 0% | 31.6 | 39,542 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 11 Mar 2024 | 15,735 | 158,202 (0%) | 0% | 4.1 | 64,356 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2024 | 7,936 | 44,631 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2024 | 15,735 | 52,567 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 34.07 per share. | 11 Mar 2024 | 7,936 | 142,467 (0%) | 0% | 34.1 | 270,345 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 11 Mar 2024 | 7,936 | 150,403 (0%) | 0% | 4.1 | 32,458 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 34.02 per share. | 11 Mar 2024 | 15,735 | 142,467 (0%) | 0% | 34.0 | 535,306 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 143,500 | 143,500 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 41,000 | 142,467 (0%) | 0% | 0 | Common Stock | |
| Stephen M. Kelsey | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 51,400 | 273,032 (0%) | 0% | 0 | Common Stock | |
| Stephen M. Kelsey | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 179,900 | 179,900 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 314,000 | 314,000 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 90,000 | 466,167 (0%) | 0% | 0 | Common Stock | |
| Jack Anders | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 92,400 | 92,400 | - | - | Stock Option (Right to Buy) | |
| Jack Anders | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 26,400 | 103,220 (0%) | 0% | 0 | Common Stock | |
| Xiaolin Wang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 84,700 | 84,700 | - | - | Stock Option (Right to Buy) | |
| Xiaolin Wang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 24,200 | 84,526 (0%) | 0% | 0 | Common Stock | |
| Jeff Cislini | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 73,500 | 73,500 | - | - | Stock Option (Right to Buy) | |
| Jeff Cislini | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 21,000 | 57,126 (0%) | 0% | 0 | Common Stock | |
| Cislini Jeff | General Counsel | Sale of securities on an exchange or to another person at price $ 27.00 per share. | 22 Jan 2024 | 1,500 | 36,126 (0%) | 0% | 27 | 40,500 | Common Stock |
| Stephen Kelsey M. | See Remarks | Sale of securities on an exchange or to another person at price $ 29.01 per share. | 08 Jan 2024 | 3,337 | 221,632 (0%) | 0% | 29.0 | 96,809 | Common Stock |
| Stephen Kelsey M. | See Remarks | Sale of securities on an exchange or to another person at price $ 29.10 per share. | 02 Jan 2024 | 13,330 | 224,969 (0%) | 0% | 29.1 | 387,884 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 29.01 per share. | 27 Dec 2023 | 33,334 | 238,299 (0%) | 0% | 29.0 | 966,996 | Common Stock |
| A. Goldsmith Mark | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 25.90 per share. | 18 Dec 2023 | 8,165 | 376,167 (0%) | 0% | 25.9 | 211,488 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 25.90 per share. | 18 Dec 2023 | 1,229 | 37,284 (0%) | 0% | 25.9 | 31,833 | Common Stock |
| M. Stephen Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 25.90 per share. | 18 Dec 2023 | 2,088 | 271,633 (0%) | 0% | 25.9 | 54,083 | Common Stock |
| Jack Anders | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 25.90 per share. | 18 Dec 2023 | 1,775 | 76,416 (0%) | 0% | 25.9 | 45,976 | Common Stock |
| Margaret Horn A. | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 15 Dec 2023 | 5,000 | 109,460 (0%) | 0% | 4.1 | 20,450 | Common Stock |
| A. Margaret Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2023 | 5,000 | 68,302 | - | - | Stock Option (Right to Buy) | |
| A. Margaret Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 25.90 per share. | 15 Dec 2023 | 2,993 | 101,467 (0%) | 0% | 25.9 | 77,524 | Common Stock |
| Margaret Horn A. | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 26.64 per share. | 15 Dec 2023 | 5,000 | 104,460 (0%) | 0% | 26.6 | 133,183 | Common Stock |
| Horn A. Margaret | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 06 Dec 2023 | 5,000 | 109,460 (0%) | 0% | 4.1 | 20,450 | Common Stock |
| A. Margaret Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2023 | 5,000 | 73,302 | - | - | Stock Option (Right to Buy) | |
| A. Horn Margaret | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 06 Dec 2023 | 5,000 | 104,460 (0%) | 0% | 25 | 125,000 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 31 Aug 2023 | 10,000 | 109,474 (0%) | 0% | 4.1 | 40,900 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Aug 2023 | 10,000 | 108,302 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 34.05 per share. | 31 Aug 2023 | 10,000 | 99,474 (0%) | 0% | 34.0 | 340,458 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 15 Aug 2023 | 5,000 | 104,474 (0%) | 0% | 4.1 | 20,450 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2023 | 5,000 | 118,302 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 30.80 per share. | 15 Aug 2023 | 1,915 | 99,474 (0%) | 0% | 30.8 | 58,981 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 30.36 per share. | 15 Aug 2023 | 3,085 | 101,389 (0%) | 0% | 30.4 | 93,652 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 29.19 per share. | 01 Aug 2023 | 16,666 | 309,114 (0%) | 0% | 29.2 | 486,502 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 32.40 per share. | 01 Aug 2023 | 16,666 | 292,448 (0%) | 0% | 32.4 | 539,978 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 26.02 per share. | 31 Jul 2023 | 1,500 | 43,227 (0%) | 0% | 26.0 | 39,030 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 24.89 per share. | 20 Jun 2023 | 2,102 | 99,474 (0%) | 0% | 24.9 | 52,321 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 24.89 per share. | 20 Jun 2023 | 2,102 | 325,780 (0%) | 0% | 24.9 | 52,321 | Common Stock |
| Jack Anders | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 24.89 per share. | 20 Jun 2023 | 1,249 | 55,094 (0%) | 0% | 24.9 | 31,089 | Common Stock |
| Jeff Cislini | General Counsel | Sale of securities on an exchange or to another person at price $ 25.14 per share. | 20 Jun 2023 | 1,239 | 44,727 (0%) | 0% | 25.1 | 31,148 | Common Stock |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 5,200 | 239,822 (0%) | 0% | 0 | Common Stock | |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Lorence H. Kim | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Lorence H. Kim | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 5,200 | 65,700 (0%) | 0% | 0 | Common Stock | |
| Eric Schmidt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Eric Schmidt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 5,200 | 21,251 (0%) | 0% | 0 | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 5,200 | 15,825 (0%) | 0% | 0 | Common Stock | |
| Barbara L. Weber | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Barbara L. Weber | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 5,200 | 15,825 (0%) | 0% | 0 | Common Stock | |
| Sushil Patel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 5,200 | 15,700 (0%) | 0% | 0 | Common Stock | |
| Sushil Patel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Flavia Borellini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 5,200 | 17,634 (0%) | 0% | 0 | Common Stock | |
| Flavia Borellini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | See Remarks | Sale of securities on an exchange or to another person at price $ 21.78 per share. | 17 Mar 2023 | 1,230 | 100,062 (0%) | 0% | 21.8 | 26,789 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 21.78 per share. | 17 Mar 2023 | 1,230 | 326,369 (0%) | 0% | 21.8 | 26,789 | Common Stock |
| Jack Anders | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 21.78 per share. | 17 Mar 2023 | 665 | 55,233 (0%) | 0% | 21.8 | 14,484 | Common Stock |
| Xiaolin Wang | See Remarks | Sale of securities on an exchange or to another person at price $ 21.78 per share. | 17 Mar 2023 | 714 | 58,813 (0%) | 0% | 21.8 | 15,551 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 22.00 per share. | 07 Mar 2023 | 231,819 | 1,453,134 (2%) | 0% | 22 | 5,100,018 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 22.00 per share. | 07 Mar 2023 | 318,181 | 618,181 (1%) | 0% | 22 | 6,999,982 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 20.43 per share. | 07 Mar 2023 | 93,800 | 1,546,934 (2%) | 0% | 20.4 | 1,916,334 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 20.85 per share. | 07 Mar 2023 | 6,200 | 1,553,134 (2%) | 0% | 20.9 | 129,270 | Common Stock |
| Margaret A. Horn | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 40,000 | 101,292 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Horn | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 140,000 | 140,000 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 140,000 | 140,000 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 40,000 | 327,599 (0%) | 0% | 0 | Common Stock | |
| Mark A. Goldsmith | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 363,000 | 363,000 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 104,000 | 355,872 (0%) | 0% | 0 | Common Stock | |
| Jack Anders | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 26,600 | 55,898 (0%) | 0% | 0 | Common Stock | |
| Jack Anders | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 93,100 | 93,100 | - | - | Stock Option (Right to Buy) | |
| Xiaolin Wang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 29,000 | 59,527 (0%) | 0% | 0 | Common Stock | |
| Xiaolin Wang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 101,500 | 101,500 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.49 per share. | 22 Feb 2023 | 45,000 | 251,872 (0%) | 0% | 0.5 | 22,050 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2023 | 45,000 | 102,446 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | See Remarks | Sale of securities on an exchange or to another person at price $ 22.94 per share. | 19 Dec 2022 | 1,220 | 61,292 (0%) | 0% | 22.9 | 27,985 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 22.94 per share. | 19 Dec 2022 | 1,220 | 287,599 (0%) | 0% | 22.9 | 27,986 | Common Stock |
| Jack Anders | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 22.94 per share. | 19 Dec 2022 | 658 | 29,298 (0%) | 0% | 22.9 | 15,095 | Common Stock |
| Xiaolin Wang | See Remarks | Sale of securities on an exchange or to another person at price $ 22.94 per share. | 19 Dec 2022 | 708 | 30,527 (0%) | 0% | 22.9 | 16,241 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 20.15 per share. | 07 Nov 2022 | 17,767 | 0 (0%) | 0% | 20.2 | 358,069 | Common Stock |
| Margaret A. Horn | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 20.41 per share. | 31 Oct 2022 | 17,767 | 17,767 (0%) | 0% | 20.4 | 362,541 | Common Stock |
| Margaret A. Horn | See Remarks | Sale of securities on an exchange or to another person at price $ 20.15 per share. | 26 Oct 2022 | 17,768 | 35,534 (0%) | 0% | 20.1 | 357,968 | Common Stock |
| Margaret A. Horn | See Remarks | Sale of securities on an exchange or to another person at price $ 19.04 per share. | 19 Sep 2022 | 1,267 | 62,512 (0%) | 0% | 19.0 | 24,127 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 19.04 per share. | 19 Sep 2022 | 1,267 | 288,819 (0%) | 0% | 19.0 | 24,127 | Common Stock |
| Jack Anders | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.04 per share. | 19 Sep 2022 | 449 | 29,956 (0%) | 0% | 19.0 | 8,550 | Common Stock |
| Xiaolin Wang | See Remarks | Sale of securities on an exchange or to another person at price $ 19.04 per share. | 19 Sep 2022 | 735 | 31,235 (0%) | 0% | 19.0 | 13,996 | Common Stock |
| Jack Anders | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2022 | 35,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Jack Anders | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2022 | 10,000 | 30,405 (0%) | 0% | 0 | Common Stock | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Aug 2022 | 10,000 | 147,446 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.49 per share. | 11 Aug 2022 | 10,000 | 206,872 (0%) | 0% | 0.5 | 4,900 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2022 | 10,336 | 157,446 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.49 per share. | 09 Aug 2022 | 10,336 | 196,872 (0%) | 0% | 0.5 | 5,065 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 22 Jul 2022 | 250,000 | 1,221,315 (2%) | 0% | 20 | 5,000,000 | Common Stock |
| Lorence H. Kim | Director | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 22 Jul 2022 | 50,000 | 60,500 (0%) | 0% | 20 | 1,000,000 | Common Stock |
| Lorence H. Kim | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jul 2022 | 10,500 | 10,500 (0%) | 0% | 0 | Common Stock | |
| Lorence H. Kim | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jul 2022 | 36,800 | 36,800 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | See Remarks | Sale of securities on an exchange or to another person at price $ 17.75 per share. | 17 Jun 2022 | 1,145 | 63,779 (0%) | 0% | 17.7 | 20,323 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 17.75 per share. | 17 Jun 2022 | 1,145 | 290,086 (0%) | 0% | 17.7 | 20,323 | Common Stock |
| Jack Anders | See Remarks | Sale of securities on an exchange or to another person at price $ 17.75 per share. | 17 Jun 2022 | 406 | 20,405 (0%) | 0% | 17.7 | 7,206 | Common Stock |
| Xiaolin Wang | See Remarks | Sale of securities on an exchange or to another person at price $ 17.75 per share. | 17 Jun 2022 | 665 | 31,970 (0%) | 0% | 17.7 | 11,803 | Common Stock |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 5,200 | 54,918 (0%) | 0% | 0 | Common Stock | |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Neil Exter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 5,200 | 28,815 (0%) | 0% | 0 | Common Stock | |
| Neil Exter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Eric Schmidt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 5,200 | 16,051 (0%) | 0% | 0 | Common Stock | |
| Eric Schmidt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 5,200 | 10,625 (0%) | 0% | 0 | Common Stock | |
| Barbara L. Weber | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Barbara L. Weber | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 5,200 | 10,625 (0%) | 0% | 0 | Common Stock | |
| Sushil Patel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 36,800 | 36,800 | - | - | Stock Option (Right to Buy) | |
| Sushil Patel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 10,500 | 10,500 (0%) | 0% | 0 | Common Stock | |
| Flavia Borellini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 18,400 | 18,400 | - | - | Stock Option (Right to Buy) | |
| Flavia Borellini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2022 | 5,200 | 12,434 (0%) | 0% | 0 | Common Stock | |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 24.71 per share. | 25 Mar 2022 | 725 | 971,315 (1%) | 0% | 24.7 | 17,915 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 25.26 per share. | 25 Mar 2022 | 12,765 | 970,590 (1%) | 0% | 25.3 | 322,444 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 24.59 per share. | 25 Mar 2022 | 29,235 | 957,825 (1%) | 0% | 24.6 | 718,889 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 23.61 per share. | 22 Mar 2022 | 37,708 | 864,061 (1%) | 0% | 23.6 | 890,286 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 23.69 per share. | 22 Mar 2022 | 53,501 | 826,353 (1%) | 0% | 23.7 | 1,267,439 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 22.15 per share. | 22 Mar 2022 | 5,440 | 701,666 (1%) | 0% | 22.2 | 120,496 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 23.18 per share. | 22 Mar 2022 | 71,186 | 772,852 (1%) | 0% | 23.2 | 1,650,091 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 24.26 per share. | 22 Mar 2022 | 49,119 | 928,590 (1%) | 0% | 24.3 | 1,191,627 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 23.99 per share. | 22 Mar 2022 | 15,410 | 879,471 (1%) | 0% | 24.0 | 369,686 | Common Stock |
| Margaret A. Horn | See Remarks | Sale of securities on an exchange or to another person at price $ 18.61 per share. | 17 Mar 2022 | 321 | 63,987 (0%) | 0% | 18.6 | 5,975 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 18.62 per share. | 17 Mar 2022 | 321 | 290,294 (0%) | 0% | 18.6 | 5,976 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 21.22 per share. | 17 Mar 2022 | 879 | 696,226 (1%) | 0% | 21.2 | 18,652 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 20.73 per share. | 17 Mar 2022 | 74,852 | 695,347 (1%) | 0% | 20.7 | 1,551,682 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 20.38 per share. | 17 Mar 2022 | 76,208 | 620,495 (1%) | 0% | 20.4 | 1,553,119 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 19.28 per share. | 17 Mar 2022 | 5,992 | 544,287 (0%) | 0% | 19.3 | 115,526 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 18.78 per share. | 17 Mar 2022 | 10,120 | 538,295 (0%) | 0% | 18.8 | 190,054 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 18.61 per share. | 17 Mar 2022 | 1,023 | 185,599 (0%) | 0% | 18.6 | 19,042 | Common Stock |
| Jack Anders | See Remarks | Sale of securities on an exchange or to another person at price $ 18.62 per share. | 17 Mar 2022 | 159 | 19,875 (0%) | 0% | 18.6 | 2,960 | Common Stock |
| Xiaolin Wang | See Remarks | Sale of securities on an exchange or to another person at price $ 18.61 per share. | 17 Mar 2022 | 240 | 31,698 (0%) | 0% | 18.6 | 4,467 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 20.93 per share. | 10 Mar 2022 | 3,110 | 528,175 (0%) | 0% | 20.9 | 65,092 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 21.23 per share. | 10 Mar 2022 | 2,489 | 525,065 (0%) | 0% | 21.2 | 52,841 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 20.57 per share. | 10 Mar 2022 | 37,911 | 522,576 (0%) | 0% | 20.6 | 779,829 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 18.35 per share. | 07 Mar 2022 | 95,926 | 334,153 (0%) | 0% | 18.3 | 1,760,242 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 18.91 per share. | 07 Mar 2022 | 7,079 | 341,232 (0%) | 0% | 18.9 | 133,864 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 20.07 per share. | 07 Mar 2022 | 39,600 | 484,665 (0%) | 0% | 20.1 | 794,772 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 19.90 per share. | 07 Mar 2022 | 18,940 | 445,065 (0%) | 0% | 19.9 | 376,906 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 19.36 per share. | 07 Mar 2022 | 42,011 | 426,125 (0%) | 0% | 19.4 | 813,333 | Common Stock |
| Thilo Schroeder | Director | Purchase of securities on an exchange or from another person at price $ 18.23 per share. | 07 Mar 2022 | 42,882 | 384,114 (0%) | 0% | 18.2 | 781,739 | Common Stock |
| Margaret A. Horn | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 38,800 | 64,308 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Horn | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 135,800 | 135,800 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 135,800 | 135,800 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 38,800 | 290,615 (0%) | 0% | 0 | Common Stock | |
| Mark A. Goldsmith | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 363,000 | 363,000 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 104,000 | 186,622 (0%) | 0% | 0 | Common Stock | |
| Jack Anders | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 40,600 | 40,600 | - | - | Stock Option (Right to Buy) | |
| Jack Anders | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 11,600 | 20,034 (0%) | 0% | 0 | Common Stock | |
| Xiaolin Wang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 70,000 | 70,000 | - | - | Stock Option (Right to Buy) | |
| Xiaolin Wang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 20,000 | 31,938 (0%) | 0% | 0 | Common Stock | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2021 | 37,721 | 167,782 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.49 per share. | 06 Dec 2021 | 37,721 | 84,193 (0%) | 0% | 0.5 | 18,483 | Common Stock |
| Margaret A. Horn | See Remarks | Sale of securities on an exchange or to another person at price $ 30.02 per share. | 17 Sep 2021 | 479 | 25,999 (0%) | 0% | 30.0 | 14,380 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 30.02 per share. | 17 Sep 2021 | 335 | 252,158 (0%) | 0% | 30.0 | 10,057 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 30.02 per share. | 17 Sep 2021 | 1,531 | 46,472 (0%) | 0% | 30.0 | 45,961 | Common Stock |
| Jack Anders | See Remarks | Sale of securities on an exchange or to another person at price $ 30.02 per share. | 17 Sep 2021 | 166 | 8,192 (0%) | 0% | 30.0 | 4,983 | Common Stock |
| Xiaolin Wang | See Remarks | Sale of securities on an exchange or to another person at price $ 30.02 per share. | 17 Sep 2021 | 250 | 12,195 (0%) | 0% | 30.0 | 7,505 | Common Stock |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 12,659 | 12,659 | - | - | Stock Option (Right to Buy) | |
| Alexis A. Borisy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 3,617 | 49,718 (0%) | 0% | 0 | Common Stock | |
| Vincent A. Miller | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 12,659 | 12,659 | - | - | Stock Option (Right to Buy) | |
| Vincent A. Miller | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 3,617 | 23,750 (0%) | 0% | 0 | Common Stock | |
| Neil Exter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 12,659 | 12,659 | - | - | Stock Option (Right to Buy) | |
| Neil Exter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 3,617 | 23,615 (0%) | 0% | 0 | Common Stock | |
| Eric Schmidt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 3,617 | 10,851 (0%) | 0% | 0 | Common Stock | |
| Eric Schmidt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 12,659 | 12,659 | - | - | Stock Option (Right to Buy) | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 12,659 | 12,659 | - | - | Stock Option (Right to Buy) | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 3,617 | 5,425 (0%) | 0% | 0 | Common Stock | |
| Barbara Weber | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 12,659 | 12,659 | - | - | Stock Option (Right to Buy) | |
| Barbara Weber | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 3,617 | 5,425 (0%) | 0% | 0 | Common Stock | |
| Flavia Borellini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 25,318 | 25,318 | - | - | Stock Option (Right to Buy) | |
| Flavia Borellini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 7,234 | 7,234 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Horn | See Remarks | Sale of securities on an exchange or to another person at price $ 34.13 per share. | 17 Jun 2021 | 464 | 26,478 (0%) | 0% | 34.1 | 15,835 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 34.12 per share. | 17 Jun 2021 | 324 | 252,493 (0%) | 0% | 34.1 | 11,056 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 33.50 per share. | 17 Jun 2021 | 20 | 48,003 (0%) | 0% | 33.5 | 670 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 34.13 per share. | 17 Jun 2021 | 1,465 | 48,023 (0%) | 0% | 34.1 | 50,000 | Common Stock |
| Jack Anders | See Remarks | Sale of securities on an exchange or to another person at price $ 34.12 per share. | 17 Jun 2021 | 160 | 8,358 (0%) | 0% | 34.1 | 5,460 | Common Stock |
| Xiaolin Wang | See Remarks | Sale of securities on an exchange or to another person at price $ 34.12 per share. | 17 Jun 2021 | 243 | 12,445 (0%) | 0% | 34.1 | 8,291 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 42.85 per share. | 26 Apr 2021 | 24,883 | 1,582,965 (2%) | 0% | 42.8 | 1,066,147 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 42.51 per share. | 26 Apr 2021 | 53 | 1,775,236 (3%) | 0% | 42.5 | 2,253 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 42.51 per share. | 26 Apr 2021 | 47 | 1,571,963 (2%) | 0% | 42.5 | 1,998 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 42.65 per share. | 26 Apr 2021 | 12,371 | 1,775,289 (3%) | 0% | 42.7 | 527,659 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 42.65 per share. | 26 Apr 2021 | 10,955 | 1,572,010 (2%) | 0% | 42.7 | 467,263 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 42.85 per share. | 26 Apr 2021 | 28,101 | 1,787,660 (3%) | 0% | 42.8 | 1,204,027 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 44.80 per share. | 08 Apr 2021 | 21,710 | 1,619,448 (2%) | 0% | 44.8 | 972,697 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 44.80 per share. | 08 Apr 2021 | 24,518 | 1,828,862 (3%) | 0% | 44.8 | 1,098,507 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 43.83 per share. | 08 Apr 2021 | 11,600 | 1,607,848 (2%) | 0% | 43.8 | 508,379 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 43.83 per share. | 08 Apr 2021 | 13,101 | 1,815,761 (3%) | 0% | 43.8 | 574,162 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 46.65 per share. | 05 Apr 2021 | 8,554 | 1,672,837 (2%) | 0% | 46.7 | 399,085 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 45.60 per share. | 05 Apr 2021 | 14,825 | 1,853,380 (3%) | 0% | 45.6 | 676,087 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 45.60 per share. | 05 Apr 2021 | 13,128 | 1,641,158 (2%) | 0% | 45.6 | 598,696 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 48.06 per share. | 05 Apr 2021 | 20,949 | 1,868,205 (3%) | 0% | 48.1 | 1,006,847 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 48.06 per share. | 05 Apr 2021 | 18,551 | 1,654,286 (2%) | 0% | 48.1 | 891,594 | Common Stock |
| Peter Svennilson | Director | Sale of securities on an exchange or to another person at price $ 46.65 per share. | 05 Apr 2021 | 9,661 | 1,889,154 (3%) | 0% | 46.7 | 450,732 | Common Stock |
| Vincent A. Miller | Director | Sale of securities on an exchange or to another person at price $ 49.00 per share. | 22 Mar 2021 | 3,200 | 20,133 (0%) | 0% | 49 | 156,800 | Common Stock |
| Vincent A. Miller | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Mar 2021 | 1,600 | 12,785 | - | - | Stock Option (Right to Buy) | |
| Vincent A. Miller | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Mar 2021 | 1,600 | 16,397 | - | - | Stock Option (Right to Buy) | |
| Vincent A. Miller | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share. | 22 Mar 2021 | 3,200 | 23,333 (0%) | 0% | 4.7 | 15,136 | Common Stock |
| Margaret A. Horn | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 15,000 | 26,198 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Horn | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 52,500 | 52,500 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 52,500 | 52,500 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 15,000 | 252,073 (0%) | 0% | 0 | Common Stock | |
| Mark A. Goldsmith | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 48,000 | 48,744 (0%) | 0% | 0 | Common Stock | |
| Mark A. Goldsmith | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 169,000 | 169,000 | - | - | Stock Option (Right to Buy) | |
| Jack Anders | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 25,900 | 25,900 | - | - | Stock Option (Right to Buy) | |
| Jack Anders | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 7,400 | 7,904 (0%) | 0% | 0 | Common Stock | |
| Xiaolin Wang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 39,200 | 39,200 | - | - | Stock Option (Right to Buy) | |
| Xiaolin Wang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 11,200 | 11,944 (0%) | 0% | 0 | Common Stock | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.12 per share. | 01 Mar 2021 | 5,000 | 5,744 (0%) | 0% | 1.1 | 5,600 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2021 | 5,000 | 58,486 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 46.00 per share. | 01 Mar 2021 | 5,000 | 744 (0%) | 0% | 46.0 | 229,981 | Common Stock |
| Margaret A. Horn | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share. | 05 Feb 2021 | 35,000 | 46,198 (0%) | 0% | 4.7 | 165,550 | Common Stock |
| Margaret A. Horn | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2021 | 35,000 | 189,800 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Horn | See Remarks | Sale of securities on an exchange or to another person at price $ 55.00 per share. | 05 Feb 2021 | 35,000 | 11,198 (0%) | 0% | 55 | 1,925,000 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 55.00 per share. | 05 Feb 2021 | 15,000 | 744 (0%) | 0% | 55 | 825,000 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2021 | 15,000 | 63,486 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.12 per share. | 05 Feb 2021 | 15,000 | 15,744 (0%) | 0% | 1.1 | 16,800 | Common Stock |
| Barbara Weber | Director | Sale of securities on an exchange or to another person at price $ 50.02 per share. | 04 Feb 2021 | 4,100 | 2,708 (0%) | 0% | 50.0 | 205,096 | Common Stock |
| Barbara Weber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Feb 2021 | 5,000 | 12,997 | - | - | Stock Option (Right to Buy) | |
| Barbara Weber | Director | Sale of securities on an exchange or to another person at price $ 51.86 per share. | 04 Feb 2021 | 900 | 1,808 (0%) | 0% | 51.9 | 46,671 | Common Stock |
| Barbara Weber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share. | 04 Feb 2021 | 5,000 | 6,808 (0%) | 0% | 4.7 | 23,650 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2021 | 5,000 | 78,486 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Feb 2021 | 246,604 | 247,093 (0%) | 0% | 0 | Common Stock | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.12 per share. | 02 Feb 2021 | 5,000 | 5,744 (0%) | 0% | 1.1 | 5,600 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 45.26 per share. | 02 Feb 2021 | 4,200 | 1,544 (0%) | 0% | 45.3 | 190,096 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 46.26 per share. | 02 Feb 2021 | 800 | 744 (0%) | 0% | 46.3 | 37,005 | Common Stock |
| Barbara Weber | Director | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 02 Feb 2021 | 5,336 | 1,808 (0%) | 0% | 45 | 240,120 | Common Stock |
| Barbara Weber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2021 | 5,336 | 13,489 | - | - | Stock Option (Right to Buy) | |
| Barbara Weber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.12 per share. | 02 Feb 2021 | 5,336 | 7,144 (0%) | 0% | 1.1 | 5,976 | Common Stock |
| Peter Svennilson | Director | Other type of transaction at price $ 0.00 per share. | 09 Dec 2020 | 22,011 | 22,011 (0%) | 0% | 0 | Common Stock | |
| Peter Svennilson | Director | Other type of transaction at price $ 0.00 per share. | 09 Dec 2020 | 469,635 | 1,681,391 (2%) | 0% | 0 | Common Stock | |
| Peter Svennilson | Director | Other type of transaction at price $ 0.00 per share. | 09 Dec 2020 | 46 | 46 (0%) | 0% | 0 | Common Stock | |
| Peter Svennilson | Director | Other type of transaction at price $ 0.00 per share. | 09 Dec 2020 | 24,857 | 46,868 (0%) | 0% | 0 | Common Stock | |
| Peter Svennilson | Director | Other type of transaction at price $ 0.00 per share. | 09 Dec 2020 | 13,068 | 20,302 (0%) | 0% | 0 | Common Stock | |
| Peter Svennilson | Director | Other type of transaction at price $ 0.00 per share. | 09 Dec 2020 | 46,868 | 0 (0%) | 0% | 0 | Common Stock | |
| Peter Svennilson | Director | Other type of transaction at price $ 0.00 per share. | 09 Dec 2020 | 530,365 | 1,898,815 (3%) | 0% | 0 | Common Stock | |
| Peter Svennilson | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 36.40 per share. | 16 Nov 2020 | 1,075,133 | 2,429,180 (4%) | 1% | 36.4 | 39,134,841 | Common Stock |
| Peter Svennilson | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 36.40 per share. | 16 Nov 2020 | 952,023 | 2,151,026 (3%) | 1% | 36.4 | 34,653,637 | Common Stock |
| Elizabeth McKee Anderson | Director | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 13 Oct 2020 | 4,780 | 26,990 (0%) | 0% | 45 | 215,100 | Common Stock |
| Elizabeth McKee Anderson | Director | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 13 Oct 2020 | 220 | 31,770 (0%) | 0% | 45 | 9,900 | Common Stock |
| Jack Anders | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.68 per share. | 13 Oct 2020 | 10,000 | 10,000 (0%) | 0% | 2.7 | 26,800 | Common Stock |
| Jack Anders | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2020 | 10,000 | 62,201 | - | - | Stock Option (Right to Buy) | |
| Jack Anders | See Remarks | Sale of securities on an exchange or to another person at price $ 44.00 per share. | 13 Oct 2020 | 10,000 | 0 (0%) | 0% | 44 | 440,000 | Common Stock |
| Vincent A. Miller | Director | Sale of securities on an exchange or to another person at price $ 39.00 per share. | 06 Oct 2020 | 6,250 | 20,133 (0%) | 0% | 39 | 243,750 | Common Stock |
| Elizabeth McKee Anderson | Director | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 06 Oct 2020 | 5,000 | 31,990 (0%) | 0% | 40 | 200,000 | Common Stock |
| Jack Anders | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2020 | 10,000 | 72,201 | - | - | Stock Option (Right to Buy) | |
| Jack Anders | See Remarks | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 06 Oct 2020 | 10,000 | 0 (0%) | 0% | 40 | 400,000 | Common Stock |
| Jack Anders | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.68 per share. | 06 Oct 2020 | 10,000 | 10,000 (0%) | 0% | 2.7 | 26,800 | Common Stock |
| Margaret A. Horn | See Remarks | Sale of securities on an exchange or to another person at price $ 35.40 per share. | 01 Oct 2020 | 12,495 | 53,302 (0%) | 0% | 35.4 | 442,321 | Common Stock |
| Margaret A. Horn | See Remarks | Sale of securities on an exchange or to another person at price $ 35.01 per share. | 01 Oct 2020 | 57,505 | 65,797 (0%) | 0% | 35.0 | 2,013,170 | Common Stock |
| Barbara L. Weber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2020 | 2,000 | 26,825 | - | - | Stock Option (Right to Buy) | |
| Barbara L. Weber | Director | Sale of securities on an exchange or to another person at price $ 36.17 per share. | 01 Oct 2020 | 7,196 | 1,808 (0%) | 0% | 36.2 | 260,313 | Common Stock |
| Barbara L. Weber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.12 per share. | 01 Oct 2020 | 7,196 | 9,004 (0%) | 0% | 1.1 | 8,060 | Common Stock |
| Barbara L. Weber | Director | Sale of securities on an exchange or to another person at price $ 36.02 per share. | 01 Oct 2020 | 804 | 1,808 (0%) | 0% | 36.0 | 28,960 | Common Stock |
| Barbara L. Weber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.12 per share. | 01 Oct 2020 | 804 | 2,612 (0%) | 0% | 1.1 | 900 | Common Stock |
| Barbara L. Weber | Director | Sale of securities on an exchange or to another person at price $ 34.76 per share. | 01 Oct 2020 | 2,000 | 1,808 (0%) | 0% | 34.8 | 69,521 | Common Stock |
| Barbara L. Weber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.12 per share. | 01 Oct 2020 | 2,000 | 3,808 (0%) | 0% | 1.1 | 2,240 | Common Stock |
| Barbara L. Weber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2020 | 7,196 | 18,825 | - | - | Stock Option (Right to Buy) | |
| Barbara L. Weber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2020 | 804 | 26,021 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2020 | 13,268 | 172,303 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share. | 28 Sep 2020 | 9,384 | 245,713 (0%) | 0% | 4.7 | 44,386 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2020 | 17,248 | 155,055 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 34.08 per share. | 28 Sep 2020 | 9,384 | 236,329 (0%) | 0% | 34.1 | 319,831 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share. | 28 Sep 2020 | 13,268 | 249,597 (0%) | 0% | 4.7 | 62,758 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 34.14 per share. | 28 Sep 2020 | 13,268 | 236,329 (0%) | 0% | 34.1 | 452,914 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share. | 28 Sep 2020 | 17,248 | 253,577 (0%) | 0% | 4.7 | 81,583 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 34.33 per share. | 28 Sep 2020 | 17,248 | 236,329 (0%) | 0% | 34.3 | 592,060 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2020 | 9,384 | 185,571 | - | - | Stock Option (Right to Buy) | |
| Vincent A. Miller | Director | Sale of securities on an exchange or to another person at price $ 34.07 per share. | 28 Sep 2020 | 450 | 26,383 (0%) | 0% | 34.1 | 15,332 | Common Stock |
| Vincent A. Miller | Director | Sale of securities on an exchange or to another person at price $ 34.11 per share. | 28 Sep 2020 | 5,300 | 26,833 (0%) | 0% | 34.1 | 180,772 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2020 | 20,076 | 563,389 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2020 | 30 | 83,486 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2020 | 42,548 | 520,841 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2020 | 10,447 | 331,229 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2020 | 10,132 | 341,676 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 34.12 per share. | 28 Sep 2020 | 1,312 | 71,879 (0%) | 0% | 34.1 | 44,762 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 34.40 per share. | 28 Sep 2020 | 42,578 | 0 (0%) | 0% | 34.4 | 1,464,854 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.13 per share. | 28 Sep 2020 | 30 | 42,578 (0%) | 0% | 1.1 | 34 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share. | 28 Sep 2020 | 42,548 | 42,548 (0%) | 0% | 4.7 | 201,252 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 34.08 per share. | 28 Sep 2020 | 21,088 | 73,191 (0%) | 0% | 34.1 | 718,652 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 34.14 per share. | 28 Sep 2020 | 30,523 | 0 (0%) | 0% | 34.1 | 1,041,918 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share. | 28 Sep 2020 | 20,076 | 30,523 (0%) | 0% | 4.7 | 94,959 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 28 Sep 2020 | 10,447 | 10,447 (0%) | 0% | 4.1 | 42,728 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 34.08 per share. | 28 Sep 2020 | 7,500 | 94,279 (0%) | 0% | 34.1 | 255,605 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 34.11 per share. | 28 Sep 2020 | 10,132 | 0 (0%) | 0% | 34.1 | 345,567 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 28 Sep 2020 | 10,132 | 10,132 (0%) | 0% | 4.1 | 41,440 | Common Stock |
| Vincent A. Miller | Director | Sale of securities on an exchange or to another person at price $ 34.02 per share. | 23 Sep 2020 | 500 | 32,133 (0%) | 0% | 34.0 | 17,010 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 33.00 per share. | 21 Sep 2020 | 14,902 | 236,427 (0%) | 0% | 33.0 | 491,805 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Sep 2020 | 100 | 194,955 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 34.02 per share. | 21 Sep 2020 | 100 | 236,329 (0%) | 0% | 34.0 | 3,402 | Common Stock |
| Stephen M. Kelsey | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share. | 21 Sep 2020 | 100 | 236,429 (0%) | 0% | 4.7 | 473 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 33.00 per share. | 21 Sep 2020 | 98 | 236,329 (0%) | 0% | 33 | 3,234 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 34.02 per share. | 21 Sep 2020 | 100 | 101,779 (0%) | 0% | 34.0 | 3,402 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 34.01 per share. | 21 Sep 2020 | 100 | 0 (0%) | 0% | 34.0 | 3,401 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 21 Sep 2020 | 100 | 100 (0%) | 0% | 4.1 | 409 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 33.00 per share. | 21 Sep 2020 | 541 | 101,879 (0%) | 0% | 33 | 17,853 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 33.15 per share. | 21 Sep 2020 | 10,097 | 0 (0%) | 0% | 33.1 | 334,713 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 21 Sep 2020 | 10,097 | 10,097 (0%) | 0% | 4.1 | 41,297 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 33.00 per share. | 21 Sep 2020 | 11,459 | 102,420 (0%) | 0% | 33.0 | 378,173 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 33.00 per share. | 21 Sep 2020 | 29,903 | 0 (0%) | 0% | 33.0 | 986,850 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 21 Sep 2020 | 29,903 | 29,903 (0%) | 0% | 4.1 | 122,303 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Sep 2020 | 100 | 351,808 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Sep 2020 | 10,097 | 351,908 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Sep 2020 | 29,903 | 362,005 | - | - | Stock Option (Right to Buy) | |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 31.03 per share. | 17 Sep 2020 | 637 | 251,329 (0%) | 0% | 31.0 | 19,767 | Common Stock |
| Stephen M. Kelsey | See Remarks | Sale of securities on an exchange or to another person at price $ 31.03 per share. | 17 Sep 2020 | 11,363 | 251,966 (0%) | 0% | 31.0 | 352,556 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 29.04 per share. | 16 Sep 2020 | 8,813 | 0 (0%) | 0% | 29.0 | 255,956 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2020 | 6,056 | 391,908 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2020 | 1,286 | 83,516 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2020 | 27,363 | 84,802 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2020 | 8,813 | 112,165 | - | - | Stock Option (Right to Buy) | |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 31.05 per share. | 16 Sep 2020 | 712 | 113,879 (0%) | 0% | 31.0 | 22,106 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 32.18 per share. | 16 Sep 2020 | 200 | 0 (0%) | 0% | 32.2 | 6,437 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 31.66 per share. | 16 Sep 2020 | 7,142 | 200 (0%) | 0% | 31.7 | 226,084 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.09 per share. | 16 Sep 2020 | 6,056 | 7,342 (0%) | 0% | 4.1 | 24,769 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.12 per share. | 16 Sep 2020 | 1,286 | 1,286 (0%) | 0% | 1.1 | 1,440 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 31.03 per share. | 16 Sep 2020 | 11,288 | 114,591 (0%) | 0% | 31.0 | 350,311 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 31.03 per share. | 16 Sep 2020 | 22,658 | 0 (0%) | 0% | 31.0 | 703,191 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 29.76 per share. | 16 Sep 2020 | 4,705 | 22,658 (0%) | 0% | 29.8 | 140,030 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.12 per share. | 16 Sep 2020 | 27,363 | 27,363 (0%) | 0% | 1.1 | 30,647 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.12 per share. | 16 Sep 2020 | 8,813 | 8,813 (0%) | 0% | 1.1 | 9,871 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 29.00 per share. | 09 Sep 2020 | 4,399 | 125,879 (0%) | 0% | 29 | 127,571 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 29.07 per share. | 09 Sep 2020 | 2,544 | 0 (0%) | 0% | 29.1 | 73,948 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.12 per share. | 09 Sep 2020 | 2,544 | 2,544 (0%) | 0% | 1.1 | 2,849 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 29.00 per share. | 09 Sep 2020 | 100 | 130,251 (0%) | 0% | 29 | 2,900 | Common Stock |
| Mark A. Goldsmith | Director, See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2020 | 2,544 | 120,978 | - | - | Stock Option (Right to Buy) |