124.4K XNAS Volume
XNAS 18 Mar, 2025 4:00 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Lloyd M. Segal | Director, PRESIDENT AND CEO | Sale of securities on an exchange or to another person at price $ 1.14 per share. | 12 Mar 2025 | 21,179 | 124,394 | - | 1.1 | 24,144 | Common Shares |
| Steve Forte | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 1.14 per share. | 12 Mar 2025 | 6,884 | 54,786 | - | 1.1 | 7,848 | Common Shares |
| Maria Koehler | EVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 1.14 per share. | 12 Mar 2025 | 3,596 | 227,813 | - | 1.1 | 4,099 | Common Shares |
| Michael Zinda | EVP, CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 1.14 per share. | 12 Mar 2025 | 5,611 | 80,297 | - | 1.1 | 6,397 | Common Shares |
| Lloyd M. Segal | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 40,000 | 145,573 | - | 0 | Common Shares | |
| Lloyd M. Segal | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 237,000 | 237,000 | - | - | Employee Stock Option (right to buy) | |
| Steve Forte | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 14,000 | 61,670 | - | 0 | Common Shares | |
| Steve Forte | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 200,000 | 200,000 | - | - | Employee Stock Option (right to buy) | |
| Steve Forte | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 85,000 | 85,000 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 14,000 | 85,908 | - | 0 | Common Shares | |
| Michael Zinda | EVP, CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 75,000 | 75,000 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2025 | 85,000 | 85,000 | - | - | Employee Stock Option (right to buy) | |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Ann D. Rhoads | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Susan M. Molineaux | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Briggs W. Morrison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| David P. Bonita | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Steven H. Stein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 54,000 | 54,000 | - | - | Stock Option (right to buy) | |
| Samarth Kulkarni | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Thomas Civik | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Lloyd M. Segal | Director, PRESIDENT AND CEO | Sale of securities on an exchange or to another person at price $ 4.62 per share. | 28 Mar 2024 | 2,650 | 110,049 | - | 4.6 | 12,243 | Common Shares |
| Lloyd M. Segal | Director, PRESIDENT AND CEO | Sale of securities on an exchange or to another person at price $ 4.63 per share. | 28 Mar 2024 | 2,491 | 107,558 | - | 4.6 | 11,533 | Common Shares |
| Steve Forte | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 4.61 per share. | 28 Mar 2024 | 789 | 44,775 | - | 4.6 | 3,637 | Common Shares |
| Steve Forte | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 4.62 per share. | 28 Mar 2024 | 825 | 45,564 | - | 4.6 | 3,812 | Common Shares |
| Maria Koehler | EVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 4.66 per share. | 28 Mar 2024 | 300 | 231,409 | - | 4.7 | 1,398 | Common Shares |
| Maria Koehler | EVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 4.64 per share. | 28 Mar 2024 | 500 | 231,709 | - | 4.6 | 2,320 | Common Shares |
| Michael Zinda | EVP, CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 4.64 per share. | 28 Mar 2024 | 450 | 72,318 | - | 4.6 | 2,088 | Common Shares |
| Michael Zinda | EVP, CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 4.66 per share. | 28 Mar 2024 | 410 | 71,908 | - | 4.7 | 1,911 | Common Shares |
| Lloyd M. Segal | Director, PRESIDENT AND CEO | Sale of securities on an exchange or to another person at price $ 4.63 per share. | 25 Mar 2024 | 2,650 | 83,866 | - | 4.6 | 12,270 | Common Shares |
| Lloyd M. Segal | Director, PRESIDENT AND CEO | Sale of securities on an exchange or to another person at price $ 4.79 per share. | 25 Mar 2024 | 2,650 | 89,166 | - | 4.8 | 12,694 | Common Shares |
| Lloyd M. Segal | Director, PRESIDENT AND CEO | Sale of securities on an exchange or to another person at price $ 4.64 per share. | 25 Mar 2024 | 2,650 | 86,516 | - | 4.6 | 12,296 | Common Shares |
| Steve Forte | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 4.60 per share. | 25 Mar 2024 | 825 | 43,037 | - | 4.6 | 3,795 | Common Shares |
| Steve Forte | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 4.79 per share. | 25 Mar 2024 | 825 | 43,862 | - | 4.8 | 3,952 | Common Shares |
| Steve Forte | EVP, CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 4.62 per share. | 25 Mar 2024 | 825 | 42,212 | - | 4.6 | 3,812 | Common Shares |
| Maria Koehler | EVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 4.60 per share. | 25 Mar 2024 | 500 | 232,709 | - | 4.6 | 2,300 | Common Shares |
| Maria Koehler | EVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 4.62 per share. | 25 Mar 2024 | 500 | 232,209 | - | 4.6 | 2,310 | Common Shares |
| Maria Koehler | EVP, CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 4.78 per share. | 25 Mar 2024 | 500 | 233,209 | - | 4.8 | 2,390 | Common Shares |
| Michael Zinda | EVP, CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 4.62 per share. | 25 Mar 2024 | 450 | 72,768 | - | 4.6 | 2,079 | Common Shares |
| Michael Zinda | EVP, CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 4.78 per share. | 25 Mar 2024 | 450 | 73,668 | - | 4.8 | 2,151 | Common Shares |
| Michael Zinda | EVP, CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 4.61 per share. | 25 Mar 2024 | 450 | 73,218 | - | 4.6 | 2,075 | Common Shares |
| Lloyd M. Segal | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 237,000 | 237,000 | - | - | Employee Stock Option (right to buy) | |
| Lloyd M. Segal | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 40,000 | 124,677 | - | 0 | Common Shares | |
| Maria Koehler | EVP, CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 85,000 | 85,000 | - | - | Employee Stock Option (right to buy) | |
| Maria Koehler | EVP, CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 14,000 | 233,709 | - | 0 | Common Shares | |
| Michael Zinda | EVP, CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 85,000 | 85,000 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 14,000 | 74,118 | - | 0 | Common Shares | |
| Steve Forte | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 85,000 | 85,000 | - | - | Employee Stock Option (right to buy) | |
| Steve Forte | EVP, CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 14,000 | 44,687 | - | 0 | Common Shares | |
| Koehler Maria | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.06 per share. | 11 Dec 2023 | 20,190 | 196,153 | - | 2.1 | 41,632 | Common Shares |
| Maria Koehler | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2023 | 20,190 | 24,229 | - | - | Employee Stock Option (right to buy) | |
| Maria Koehler | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.42 per share. | 11 Dec 2023 | 23,556 | 219,709 | - | 2.4 | 57,123 | Common Shares |
| Koehler Maria | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Dec 2023 | 23,556 | 87,691 | - | - | Employee Stock Option (right to buy) | |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Ann D. Rhoads | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Todd A. Foley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Briggs W. Morrison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| David P. Bonita | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Samarth Kulkarni | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Thomas Civik | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2023 | 27,200 | 27,200 | - | - | Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 12.02 per share. | 07 Jun 2023 | 2,869 | 60,118 | - | 12.0 | 34,485 | Common Shares |
| Michael Zinda | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 12.03 per share. | 07 Jun 2023 | 6,404 | 62,987 | - | 12.0 | 77,040 | Common Shares |
| Michael Zinda | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 12.04 per share. | 06 Jun 2023 | 1,200 | 69,391 | - | 12.0 | 14,448 | Common Shares |
| Lloyd M. Segal | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2023 | 78,550 | 84,677 | - | 0 | Common Shares | |
| Lloyd M. Segal | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2023 | 344,200 | 344,200 | - | - | Employee Stock Option (right to buy) | |
| Steve Forte | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2023 | 24,530 | 30,687 | - | 0 | Common Shares | |
| Steve Forte | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2023 | 111,050 | 111,050 | - | - | Employee Stock Option (right to buy) | |
| Maria Koehler | EVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2023 | 119,250 | 119,250 | - | - | Employee Stock Option (right to buy) | |
| Maria Koehler | EVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2023 | 26,450 | 175,963 | - | 0 | Common Shares | |
| Michael Zinda | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2023 | 97,100 | 97,100 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2023 | 24,550 | 70,591 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 3,014 | 25,131 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 62,026 | 62,026 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 4,721 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 4,721 | 4,721 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 287,157 | 563,403 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 21,854 | 42,877 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 1,240 | 22,117 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 65,957 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 2,065 | 65,957 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 9,561 | 18,761 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 1,866 | 63,892 | - | 0 | Common Shares | |
| Jerel Davis | Director | Other type of transaction at price $ 0.00 per share. | 29 Dec 2022 | 8,638 | 16,949 | - | 0 | Common Shares | |
| Maria Koehler | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.43 per share. | 20 Dec 2022 | 51 | 149,513 | - | 2.4 | 124 | Common Shares |
| Maria Koehler | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2022 | 48,456 | 44,419 | - | - | Employee Stock Option (right to buy) | |
| Maria Koehler | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2022 | 51 | 111,247 | - | - | Employee Stock Option (right to buy) | |
| Maria Koehler | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.06 per share. | 20 Dec 2022 | 48,456 | 149,462 | - | 2.1 | 99,916 | Common Shares |
| Jerel Davis | Director | Sale of securities on an exchange or to another person at price $ 16.00 per share. | 09 Dec 2022 | 250,000 | 2,094,451 | - | 16 | 4,000,000 | Common Shares |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 10,099 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 12.25 per share. | 03 Jun 2022 | 250,000 | 2,344,451 | - | 12.3 | 3,062,925 | Common Shares |
| Jerel Davis | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 12.25 per share. | 03 Jun 2022 | 438,795 | 1,464,875 | - | 12.3 | 5,375,985 | Common Shares |
| Jerel Davis | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 12.25 per share. | 03 Jun 2022 | 13,199 | 44,065 | - | 12.3 | 161,710 | Common Shares |
| Jerel Davis | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 12.25 per share. | 03 Jun 2022 | 14,611 | 48,776 | - | 12.3 | 179,010 | Common Shares |
| Jerel Davis | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 12.25 per share. | 03 Jun 2022 | 33,395 | 111,484 | - | 12.3 | 409,146 | Common Shares |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 614,315 | 850,560 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 132,692 | 132,692 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 18,478 | 25,587 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 3,992 | 136,684 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 20,454 | 28,322 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 4,419 | 141,103 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 141,103 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 2,653 | 14,429 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 46,753 | 64,731 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 10,099 | 10,099 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 03 Jun 2022 | 6,448 | 20,877 | - | 0 | Common Shares | |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2022 | 49,000 | 49,000 | - | - | Stock Option (right to buy) | |
| Ann D. Rhoads | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2022 | 49,000 | 49,000 | - | - | Stock Option (right to buy) | |
| Todd A. Foley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2022 | 49,000 | 49,000 | - | - | Stock Option (right to buy) | |
| Briggs W. Morrison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2022 | 49,000 | 49,000 | - | - | Stock Option (right to buy) | |
| David P. Bonita | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2022 | 49,000 | 49,000 | - | - | Stock Option (right to buy) | |
| Samarth Kulkarni | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2022 | 49,000 | 49,000 | - | - | Stock Option (right to buy) | |
| Thomas Civik | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2022 | 49,000 | 49,000 | - | - | Stock Option (right to buy) | |
| Jerel Davis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2022 | 49,000 | 49,000 | - | - | Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 11.30 per share. | 15 Mar 2022 | 533 | 46,041 | - | 11.3 | 6,023 | Common Shares |
| Lloyd M. Segal | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jan 2022 | 300,000 | 300,000 | - | - | Employee Stock Option (right to buy) | |
| Steve Forte | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jan 2022 | 100,000 | 100,000 | - | - | Employee Stock Option (right to buy) | |
| Maria Koehler | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jan 2022 | 115,000 | 115,000 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Jan 2022 | 115,000 | 115,000 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.64 per share. | 23 Nov 2021 | 4,122 | 4,655 | - | 1.6 | 6,748 | Common Shares |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Nov 2021 | 10,473 | 137,993 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Nov 2021 | 19,590 | 35,260 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Nov 2021 | 11,856 | 0 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Nov 2021 | 4,122 | 0 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.42 per share. | 23 Nov 2021 | 10,473 | 46,574 | - | 2.4 | 25,397 | Common Shares |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.06 per share. | 23 Nov 2021 | 19,590 | 36,101 | - | 2.1 | 40,395 | Common Shares |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.64 per share. | 23 Nov 2021 | 11,856 | 16,511 | - | 1.6 | 19,408 | Common Shares |
| Thomas Civik | Director | Purchase of securities on an exchange or from another person at price $ 28.08 per share. | 16 Nov 2021 | 7,500 | 7,500 | - | 28.1 | 210,600 | Common Shares |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 27.20 per share. | 15 Nov 2021 | 16,100 | 4,433 | - | 27.2 | 437,920 | Common Shares |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 27.87 per share. | 15 Nov 2021 | 3,900 | 533 | - | 27.9 | 108,693 | Common Shares |
| Thomas Civik | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Sep 2021 | 42,000 | 42,000 | - | - | Stock Option (right to buy) | |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.00 per share. | 03 Sep 2021 | 212 | 96,216 | - | 34 | 7,208 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.92 per share. | 03 Sep 2021 | 26 | 96,190 | - | 33.9 | 882 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.93 per share. | 03 Sep 2021 | 861 | 3,177,041 | - | 33.9 | 29,214 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.00 per share. | 03 Sep 2021 | 6,985 | 3,177,902 | - | 34 | 237,490 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.24 per share. | 31 Aug 2021 | 483 | 96,428 | - | 34.2 | 16,538 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.24 per share. | 31 Aug 2021 | 15,941 | 3,184,887 | - | 34.2 | 545,820 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.98 per share. | 31 Aug 2021 | 382 | 96,911 | - | 34.0 | 12,980 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.98 per share. | 31 Aug 2021 | 12,586 | 3,200,828 | - | 34.0 | 427,672 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.94 per share. | 31 Aug 2021 | 249 | 97,293 | - | 33.9 | 8,451 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.94 per share. | 31 Aug 2021 | 8,223 | 3,213,414 | - | 33.9 | 279,089 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.52 per share. | 26 Aug 2021 | 4,157 | 3,235,021 | - | 34.5 | 143,500 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.92 per share. | 26 Aug 2021 | 197 | 97,542 | - | 33.9 | 6,682 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.92 per share. | 26 Aug 2021 | 6,500 | 3,221,637 | - | 33.9 | 220,480 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.94 per share. | 26 Aug 2021 | 209 | 97,739 | - | 33.9 | 7,093 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.94 per share. | 26 Aug 2021 | 6,884 | 3,228,137 | - | 33.9 | 233,643 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.52 per share. | 26 Aug 2021 | 126 | 97,948 | - | 34.5 | 4,350 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.06 per share. | 23 Aug 2021 | 209 | 98,401 | - | 34.1 | 7,119 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.34 per share. | 23 Aug 2021 | 208 | 98,074 | - | 34.3 | 7,143 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.34 per share. | 23 Aug 2021 | 6,874 | 3,239,178 | - | 34.3 | 236,053 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.07 per share. | 23 Aug 2021 | 119 | 98,282 | - | 34.1 | 4,054 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.07 per share. | 23 Aug 2021 | 3,920 | 3,246,052 | - | 34.1 | 133,554 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.06 per share. | 23 Aug 2021 | 6,885 | 3,249,972 | - | 34.1 | 234,503 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.99 per share. | 17 Aug 2021 | 2,852 | 3,256,857 | - | 34.0 | 96,939 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.99 per share. | 17 Aug 2021 | 78 | 98,610 | - | 34.0 | 2,651 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.99 per share. | 17 Aug 2021 | 2,852 | 3,256,857 | - | 34.0 | 96,939 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.12 per share. | 17 Aug 2021 | 512 | 98,688 | - | 34.1 | 17,469 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.12 per share. | 17 Aug 2021 | 16,886 | 3,259,439 | - | 34.1 | 576,150 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.12 per share. | 17 Aug 2021 | 16,886 | 3,259,439 | - | 34.1 | 576,150 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 33.99 per share. | 17 Aug 2021 | 78 | 98,610 | - | 34.0 | 2,651 | Common Stock |
| David P. Bonita | Director | Sale of securities on an exchange or to another person at price $ 34.12 per share. | 17 Aug 2021 | 512 | 98,688 | - | 34.1 | 17,469 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 34.45 per share. | 16 Aug 2021 | 700 | 20,533 | - | 34.5 | 24,115 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 33.97 per share. | 16 Aug 2021 | 14,300 | 21,233 | - | 34.0 | 485,771 | Common Stock |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Aug 2021 | 2,279 | 2,279 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Aug 2021 | 2,260 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Aug 2021 | 2,260 | 2,260 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Aug 2021 | 19 | 11,776 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Aug 2021 | 2,279 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 Aug 2021 | 152,071 | 231,211 | - | 0 | Common Shares | |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.10 per share. | 09 Jul 2021 | 313 | 2,242,636 | - | 34.1 | 10,673 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.58 per share. | 09 Jul 2021 | 25,246 | 2,242,949 | - | 33.6 | 847,761 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.06 per share. | 09 Jul 2021 | 1,792 | 2,268,195 | - | 33.1 | 59,244 | Common Shares |
| Lloyd M. Segal | President and CEO | Sale of securities on an exchange or to another person at price $ 35.61 per share. | 28 Jun 2021 | 1,542 | 94,466 | - | 35.6 | 54,911 | Common Stock |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.82 per share. | 28 Jun 2021 | 1,190 | 2,271,177 | - | 34.8 | 41,436 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.29 per share. | 28 Jun 2021 | 1,190 | 2,269,987 | - | 33.3 | 39,615 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.06 per share. | 28 Jun 2021 | 6,080 | 2,272,367 | - | 34.1 | 207,085 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.51 per share. | 24 Jun 2021 | 9,943 | 2,278,447 | - | 33.5 | 333,190 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.53 per share. | 24 Jun 2021 | 2,697 | 2,288,390 | - | 33.5 | 90,430 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.63 per share. | 21 Jun 2021 | 14,006 | 2,293,384 | - | 34.6 | 485,028 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 32.98 per share. | 21 Jun 2021 | 622 | 2,291,087 | - | 33.0 | 20,514 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.09 per share. | 21 Jun 2021 | 189 | 2,291,709 | - | 34.1 | 6,443 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.36 per share. | 21 Jun 2021 | 1,486 | 2,291,898 | - | 33.4 | 49,573 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.80 per share. | 21 Jun 2021 | 2,556 | 2,307,390 | - | 33.8 | 86,393 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.12 per share. | 17 Jun 2021 | 753 | 2,313,912 | - | 34.1 | 25,692 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.03 per share. | 17 Jun 2021 | 1,410 | 2,309,946 | - | 34.0 | 47,982 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.46 per share. | 17 Jun 2021 | 2,556 | 2,311,356 | - | 33.5 | 85,524 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.78 per share. | 17 Jun 2021 | 13,575 | 2,314,665 | - | 33.8 | 458,564 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.33 per share. | 14 Jun 2021 | 1,862 | 2,328,240 | - | 33.3 | 62,060 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.09 per share. | 14 Jun 2021 | 881 | 2,330,102 | - | 33.1 | 29,152 | Common Shares |
| Lloyd M. Segal | President and CEO | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 09 Jun 2021 | 1,576 | 96,008 | - | 35 | 55,160 | Common Stock |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 32.80 per share. | 08 Jun 2021 | 3,985 | 2,354,065 | - | 32.8 | 130,708 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.79 per share. | 08 Jun 2021 | 10,738 | 2,330,983 | - | 34.8 | 373,575 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.42 per share. | 08 Jun 2021 | 4,785 | 2,341,721 | - | 34.4 | 164,700 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.41 per share. | 08 Jun 2021 | 7,559 | 2,346,506 | - | 33.4 | 252,546 | Common Shares |
| Lloyd M. Segal | President and CEO | Sale of securities on an exchange or to another person at price $ 31.74 per share. | 03 Jun 2021 | 6,648 | 126,936 | - | 31.7 | 211,008 | Common Stock |
| Lloyd M. Segal | President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2021 | 5,000 | 283,683 | - | - | Employee Stock Option (right to buy) | |
| Lloyd M. Segal | President and CEO | Sale of securities on an exchange or to another person at price $ 31.25 per share. | 03 Jun 2021 | 5,000 | 5,000 | - | 31.3 | 156,250 | Common Stock |
| Lloyd M. Segal | President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.64 per share. | 03 Jun 2021 | 5,000 | 10,000 | - | 1.6 | 8,185 | Common Stock |
| Lloyd M. Segal | President and CEO | Sale of securities on an exchange or to another person at price $ 31.36 per share. | 03 Jun 2021 | 12,172 | 97,584 | - | 31.4 | 381,714 | Common Stock |
| Lloyd M. Segal | President and CEO | Sale of securities on an exchange or to another person at price $ 30.64 per share. | 03 Jun 2021 | 17,180 | 109,756 | - | 30.6 | 526,395 | Common Stock |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 31.92 per share. | 03 Jun 2021 | 9,824 | 2,373,848 | - | 31.9 | 313,582 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 32.96 per share. | 03 Jun 2021 | 8,379 | 2,358,050 | - | 33.0 | 276,172 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 32.25 per share. | 03 Jun 2021 | 749 | 2,366,429 | - | 32.2 | 24,155 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 30.74 per share. | 03 Jun 2021 | 1,058 | 2,367,178 | - | 30.7 | 32,523 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 31.28 per share. | 03 Jun 2021 | 2,068 | 2,368,236 | - | 31.3 | 64,687 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 30.80 per share. | 03 Jun 2021 | 3,544 | 2,370,304 | - | 30.8 | 109,155 | Common Shares |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 01 Jun 2021 | 1,128 | 1,128 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 01 Jun 2021 | 1,119 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 01 Jun 2021 | 1,119 | 1,119 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 01 Jun 2021 | 9 | 11,757 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 01 Jun 2021 | 1,128 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 01 Jun 2021 | 75,000 | 383,282 | - | 0 | Common Shares | |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 32.67 per share. | 28 May 2021 | 7,377 | 2,393,081 | - | 32.7 | 241,007 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 32.42 per share. | 28 May 2021 | 130 | 2,383,672 | - | 32.4 | 4,215 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 31.83 per share. | 28 May 2021 | 2,608 | 2,383,802 | - | 31.8 | 83,013 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 32.50 per share. | 28 May 2021 | 6,671 | 2,386,410 | - | 32.5 | 216,808 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.59 per share. | 25 May 2021 | 44 | 2,414,551 | - | 33.6 | 1,478 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 32.87 per share. | 25 May 2021 | 2,852 | 2,414,595 | - | 32.9 | 93,745 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 32.74 per share. | 25 May 2021 | 9,839 | 2,404,712 | - | 32.7 | 322,129 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.01 per share. | 25 May 2021 | 751 | 2,403,961 | - | 33.0 | 24,791 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 32.81 per share. | 25 May 2021 | 1,906 | 2,402,055 | - | 32.8 | 62,536 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.16 per share. | 25 May 2021 | 1,597 | 2,400,458 | - | 33.2 | 52,957 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.28 per share. | 21 May 2021 | 8,219 | 2,417,447 | - | 34.3 | 281,747 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.30 per share. | 21 May 2021 | 1,563 | 2,425,666 | - | 33.3 | 52,048 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.80 per share. | 21 May 2021 | 133,359 | 2,427,229 | - | 34.8 | 4,640,893 | Common Shares |
| Lloyd M. Segal | President and CEO | Sale of securities on an exchange or to another person at price $ 35.03 per share. | 20 May 2021 | 3,770 | 133,584 | - | 35.0 | 132,065 | Common Stock |
| Lloyd M. Segal | President and CEO | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 18 May 2021 | 1,800 | 141,154 | - | 35 | 63,000 | Common Stock |
| Lloyd M. Segal | President and CEO | Sale of securities on an exchange or to another person at price $ 35.06 per share. | 18 May 2021 | 3,800 | 137,354 | - | 35.1 | 133,228 | Common Stock |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 18 May 2021 | 1,939 | 2,564,975 | - | 35 | 67,865 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.23 per share. | 18 May 2021 | 4,029 | 2,566,914 | - | 34.2 | 137,913 | Common Shares |
| Todd A. Foley | Director | Other type of transaction at price $ 0.00 per share. | 18 May 2021 | 21,834 | 2,570,943 | - | 0 | Common Shares | |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 35.15 per share. | 18 May 2021 | 40 | 2,592,777 | - | 35.2 | 1,406 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.61 per share. | 18 May 2021 | 3,763 | 2,592,817 | - | 34.6 | 130,237 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 33.90 per share. | 18 May 2021 | 6,509 | 2,596,580 | - | 33.9 | 220,655 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 35.19 per share. | 18 May 2021 | 265 | 2,560,588 | - | 35.2 | 9,325 | Common Shares |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 34.66 per share. | 18 May 2021 | 4,122 | 2,560,853 | - | 34.7 | 142,869 | Common Shares |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 31.65 per share. | 17 May 2021 | 732 | 49,801 | - | 31.6 | 23,165 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 33.07 per share. | 17 May 2021 | 1,829 | 35,533 | - | 33.1 | 60,493 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 32.72 per share. | 17 May 2021 | 12,439 | 37,362 | - | 32.7 | 407,053 | Common Stock |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 21,000 | 21,000 | - | - | Stock Option (right to buy) | |
| Ann D. Rhoads | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 21,000 | 21,000 | - | - | Stock Option (right to buy) | |
| Todd A. Foley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 21,000 | 21,000 | - | - | Stock Option (right to buy) | |
| Briggs Morrison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 21,000 | 21,000 | - | - | Stock Option (right to buy) | |
| David P. Bonita | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 21,000 | 21,000 | - | - | Stock Option (right to buy) | |
| Samarth Kulkarni | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 21,000 | 21,000 | - | - | Stock Option (right to buy) | |
| Jerel Davis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 21,000 | 21,000 | - | - | Stock Option (right to buy) | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 3,473 | 3,473 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 16,079 | 144,879 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 912 | 11,748 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 3,473 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 1,373 | 47,008 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 6,355 | 57,264 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 45,635 | 45,635 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 211,277 | 1,903,670 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 1,930 | 10,836 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 48,528 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 1,520 | 48,528 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 05 May 2021 | 7,035 | 63,387 | - | 0 | Common Shares | |
| Lloyd M. Segal | President and CEO | Sale of securities on an exchange or to another person at price $ 35.01 per share. | 15 Apr 2021 | 5,512 | 142,954 | - | 35.0 | 192,975 | Common Stock |
| Todd A. Foley | Director | Sale of securities on an exchange or to another person at price $ 28.18 per share. | 12 Mar 2021 | 376,412 | 2,627,360 | - | 28.2 | 10,607,290 | Common Shares |
| Todd A. Foley | Director | Other type of transaction at price $ 0.00 per share. | 12 Mar 2021 | 24,271 | 2,603,089 | - | - | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 5,176 | 5,176 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 745 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 745 | 745 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 6 | 8,906 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 751 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 751 | 751 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 50,000 | 458,282 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 5,176 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 824 | 8,900 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 6,000 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 6,000 | 6,000 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 16 Feb 2021 | 300,000 | 2,594,451 | - | 0 | Common Shares | |
| Lloyd M. Segal | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 125,000 | 125,000 | - | - | Employee Stock Option (right to buy) | |
| Steve Forte | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 71,000 | 71,000 | - | - | Employee Stock Option (right to buy) | |
| Maria Koehler | EVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 125,000 | 125,000 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Feb 2021 | 125,000 | 125,000 | - | - | Employee Stock Option (right to buy) | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 751 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 751 | 751 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 50,000 | 508,282 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 4,313 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 4,313 | 4,313 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 745 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 745 | 745 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 6 | 8,076 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 687 | 8,070 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 5,000 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 5,000 | 5,000 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 250,000 | 2,894,451 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 2,764 | 7,383 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 4,328 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 4,328 | 4,328 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 20,037 | 160,958 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 1,820 | 4,619 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 60,472 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 1,893 | 60,472 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 8,766 | 70,422 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 1,711 | 58,579 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 7,919 | 63,619 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 56,868 | 56,868 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 29 Jan 2021 | 263,278 | 2,114,947 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 153,579 | 2,378,225 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 745 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 745 | 745 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 6 | 2,799 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 751 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 751 | 751 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 50,000 | 558,282 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 4,744 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 5,113 | 79,188 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 4,744 | 4,744 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 756 | 2,793 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 5,500 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 5,500 | 5,500 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 275,000 | 3,144,451 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 975 | 2,037 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 1,388 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 1,388 | 1,388 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 11,688 | 180,995 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 1,062 | 1,062 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 35,276 | 0 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 33,173 | 33,173 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 998 | 34,171 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 4,620 | 71,538 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 14 Jan 2021 | 1,105 | 35,276 | - | 0 | Common Shares | |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 34.63 per share. | 28 Dec 2020 | 4,207 | 51,483 | - | 34.6 | 145,688 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 35.01 per share. | 28 Dec 2020 | 950 | 50,533 | - | 35.0 | 33,260 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2020 | 48 | 54,850 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 34.60 per share. | 28 Dec 2020 | 322 | 70,229 | - | 34.6 | 11,141 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.06 per share. | 28 Dec 2020 | 48 | 85,277 | - | 2.1 | 99 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 34.24 per share. | 28 Dec 2020 | 14,726 | 70,551 | - | 34.2 | 504,218 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 33.30 per share. | 28 Dec 2020 | 14,539 | 55,690 | - | 33.3 | 484,149 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.64 per share. | 22 Dec 2020 | 15,706 | 100,935 | - | 1.6 | 25,711 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.06 per share. | 22 Dec 2020 | 25,606 | 126,541 | - | 2.1 | 52,800 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 34.00 per share. | 22 Dec 2020 | 1,612 | 124,929 | - | 34 | 54,808 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 33.36 per share. | 22 Dec 2020 | 39,700 | 85,229 | - | 33.4 | 1,324,392 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.64 per share. | 22 Dec 2020 | 1,976 | 87,205 | - | 1.6 | 3,235 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.06 per share. | 22 Dec 2020 | 4,771 | 91,976 | - | 2.1 | 9,838 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.42 per share. | 22 Dec 2020 | 9,488 | 101,464 | - | 2.4 | 23,008 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 33.48 per share. | 22 Dec 2020 | 12,556 | 88,908 | - | 33.5 | 420,375 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 34.26 per share. | 22 Dec 2020 | 3,679 | 85,229 | - | 34.3 | 126,043 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.06 per share. | 22 Dec 2020 | 432 | 85,661 | - | 2.1 | 891 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 33.14 per share. | 22 Dec 2020 | 432 | 85,229 | - | 33.1 | 14,316 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2020 | 15,706 | 13,832 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2020 | 25,606 | 60,101 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2020 | 1,976 | 11,856 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2020 | 4,771 | 55,330 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2020 | 9,488 | 148,466 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2020 | 432 | 54,898 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.42 per share. | 21 Dec 2020 | 40,000 | 125,229 | - | 2.4 | 97,000 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 33.08 per share. | 21 Dec 2020 | 40,000 | 85,229 | - | 33.1 | 1,323,200 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Dec 2020 | 40,000 | 157,954 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 34.59 per share. | 16 Dec 2020 | 8,121 | 85,429 | - | 34.6 | 280,905 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2020 | 6,876 | 4,122 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2020 | 2,080 | 29,538 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2020 | 8,321 | 85,707 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.64 per share. | 16 Dec 2020 | 6,876 | 92,105 | - | 1.6 | 11,256 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.64 per share. | 16 Dec 2020 | 2,080 | 94,185 | - | 1.6 | 3,405 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 35.17 per share. | 16 Dec 2020 | 8,022 | 86,163 | - | 35.2 | 282,134 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 36.01 per share. | 16 Dec 2020 | 934 | 85,229 | - | 36.0 | 33,633 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.06 per share. | 16 Dec 2020 | 8,321 | 93,550 | - | 2.1 | 17,158 | Common Stock |
| Michael Zinda | EVP, Chief Science Officer | Sale of securities on an exchange or to another person at price $ 35.10 per share. | 16 Dec 2020 | 200 | 85,229 | - | 35.1 | 7,020 | Common Stock |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 15 Dec 2020 | 8,579 | 76,158 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 15 Dec 2020 | 9,497 | 84,301 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 15 Dec 2020 | 285,217 | 2,531,804 | - | 0 | Common Shares | |
| Jerel Davis | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 15 Dec 2020 | 21,707 | 192,683 | - | 0 | Common Shares | |
| Carol A. Schafer | Director | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 23 Jun 2020 | 8,000 | 8,000 | - | 20 | 160,000 | Common Shares |
| Ann D. Rhoads | Director | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 23 Jun 2020 | 4,000 | 4,000 | - | 20 | 80,000 | Common Shares |
| Lloyd M. Segal | President and CEO | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 23 Jun 2020 | 5,000 | 5,000 | - | 20 | 100,000 | Common Stock |
| Todd A. Foley | Director | 23 Jun 2020 | 952,191 | 2,753,772 | - | - | Common Shares | ||
| Todd A. Foley | Director | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 23 Jun 2020 | 250,000 | 3,003,772 | - | 20 | 5,000,000 | Common Shares |
| Todd A. Foley | Director | 23 Jun 2020 | 1,801,581 | 0 | - | - | Class A Preferred Shares | ||
| Todd A. Foley | Director | 23 Jun 2020 | 952,191 | 0 | - | - | Class B Preferred Shares | ||
| Todd A. Foley | Director | 23 Jun 2020 | 1,801,581 | 1,801,581 | - | - | Common Shares | ||
| Briggs Morrison | Director | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 23 Jun 2020 | 4,800 | 4,800 | - | 20 | 96,000 | Common Shares |
| David P. Bonita | Director | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 23 Jun 2020 | 99,200 | 99,200 | - | 20 | 1,984,000 | Common Shares |
| David P. Bonita | Director | 23 Jun 2020 | 2,601,325 | 0 | - | - | Class B Preferred Shares | ||
| David P. Bonita | Director | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 23 Jun 2020 | 675,000 | 3,276,325 | - | 20 | 13,500,000 | Common Shares |
| David P. Bonita | Director | 23 Jun 2020 | 2,601,325 | 2,601,325 | - | - | Common Shares | ||
| Steve Forte | EVP, Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 23 Jun 2020 | 5,000 | 5,000 | - | 20 | 100,000 | Common Shares |
| Jerel Davis | Director | 23 Jun 2020 | 2,054,198 | 0 | - | - | Class A Preferred Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 2,054,198 | 2,705,660 | - | - | Common Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 156,335 | 205,915 | - | - | Common Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 68,398 | 90,090 | - | - | Common Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 61,791 | 81,387 | - | - | Common Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 2,443,883 | 2,443,883 | - | - | Common Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 111,361 | 2,817,021 | - | - | Common Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 8,475 | 214,390 | - | - | Common Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 3,708 | 93,798 | - | - | Common Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 3,350 | 84,737 | - | - | Common Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 875,568 | 3,319,451 | - | - | Common Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 458,282 | 458,282 | - | - | Common Shares | ||
| Jerel Davis | Director | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 23 Jun 2020 | 150,000 | 608,282 | - | 20 | 3,000,000 | Common Shares |
| Jerel Davis | Director | Purchase of securities on an exchange or from another person at price $ 20.00 per share. | 23 Jun 2020 | 100,000 | 3,419,451 | - | 20 | 2,000,000 | Common Shares |
| Jerel Davis | Director | 23 Jun 2020 | 156,335 | 0 | - | - | Class A Preferred Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 68,398 | 0 | - | - | Class A Preferred Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 61,791 | 0 | - | - | Class A Preferred Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 2,443,883 | 0 | - | - | Class A Preferred Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 111,361 | 0 | - | - | Class B Preferred Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 8,475 | 0 | - | - | Class B Preferred Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 3,708 | 0 | - | - | Class B Preferred Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 3,350 | 0 | - | - | Class B Preferred Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 875,568 | 0 | - | - | Class B Preferred Shares | ||
| Jerel Davis | Director | 23 Jun 2020 | 458,282 | 0 | - | - | Class B Preferred Shares | ||
| Ann D. Rhoads | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 38,907 | 38,907 | - | - | Employee Stock Option (right to buy) | |
| Lloyd M. Segal | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 354,668 | 354,668 | - | - | Employee Stock Option (right to buy) | |
| Steve Forte | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 41,240 | 41,240 | - | - | Employee Stock Option (right to buy) | |
| Maria Koehler | EVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 41,240 | 41,240 | - | - | Employee Stock Option (right to buy) | |
| Michael Zinda | EVP, Chief Science Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 41,240 | 41,240 | - | - | Employee Stock Option (right to buy) |