725.1K XNAS Volume
XNAS 19 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Margaret A. Pax | Director | Purchase of securities on an exchange or from another person at price $ 150.69 per share. | 17 Mar 2025 | 250 | 1,043 (0%) | 0% | 150.7 | 37,673 | Common Stock |
| Tony J. Hunt | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 155.38 per share. | 03 Mar 2025 | 10,142 | 136,301 (0%) | 0% | 155.4 | 1,575,864 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 155.38 per share. | 03 Mar 2025 | 386 | 16,062 (0%) | 0% | 155.4 | 59,977 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 4,826 | 16,448 (0%) | 0% | 0 | Common Stock | |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 4,542 | 4,542 | - | - | Stock Option (Right to Buy) | |
| Jason K. Garland | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 6,056 | 6,056 | - | - | Stock Option (Right to Buy) | |
| Jason K. Garland | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 6,435 | 13,795 (0%) | 0% | 0 | Common Stock | |
| James R. Bylund | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 6,435 | 25,198 (0%) | 0% | 0 | Common Stock | |
| James R. Bylund | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 6,056 | 6,056 | - | - | Stock Option (Right to Buy) | |
| James R. Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 155.38 per share. | 03 Mar 2025 | 1,239 | 23,959 (0%) | 0% | 155.4 | 192,516 | Common Stock |
| Olivier Loeillot | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 13,627 | 13,627 | - | - | Stock Option (Right to Buy) | |
| Olivier Loeillot | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 14,480 | 46,693 (0%) | 0% | 0 | Common Stock | |
| Tony J. Hunt | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.54 per share. | 27 Feb 2025 | 2,825 | 146,443 (0%) | 0% | 156.5 | 442,226 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.54 per share. | 27 Feb 2025 | 391 | 11,622 (0%) | 0% | 156.5 | 61,207 | Common Stock |
| Jason K. Garland | CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.54 per share. | 27 Feb 2025 | 316 | 7,360 (0%) | 0% | 156.5 | 49,467 | Common Stock |
| James R. Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.54 per share. | 27 Feb 2025 | 1,285 | 18,763 (0%) | 0% | 156.5 | 201,154 | Common Stock |
| Olivier Loeillot | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 156.54 per share. | 27 Feb 2025 | 343 | 32,213 (0%) | 0% | 156.5 | 53,693 | Common Stock |
| Tony J. Hunt | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.74 per share. | 24 Feb 2025 | 2,380 | 149,268 (0%) | 0% | 164.7 | 392,081 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.74 per share. | 24 Feb 2025 | 275 | 12,013 (0%) | 0% | 164.7 | 45,304 | Common Stock |
| James R. Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.74 per share. | 24 Feb 2025 | 543 | 20,048 (0%) | 0% | 164.7 | 89,454 | Common Stock |
| Hunt J. Tony | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.87 per share. | 05 Dec 2024 | 11,808 | 151,648 (0%) | 0% | 33.9 | 399,937 | Common Stock |
| Tony J. Hunt | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2024 | 11,808 | 8,856 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.87 per share. | 21 Nov 2024 | 24,246 | 164,086 (0%) | 0% | 33.9 | 821,212 | Common Stock |
| Tony J. Hunt | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Nov 2024 | 24,246 | 0 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director | Sale of securities on an exchange or to another person at price $ 139.67 per share. | 21 Nov 2024 | 24,246 | 139,840 (0%) | 0% | 139.7 | 3,386,439 | Common Stock |
| Jason K. Garland | CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 123.41 per share. | 20 Nov 2024 | 367 | 7,676 (0%) | 0% | 123.4 | 45,291 | Common Stock |
| Olivier Loeillot | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 123.41 per share. | 20 Nov 2024 | 861 | 32,556 (0%) | 0% | 123.4 | 106,256 | Common Stock |
| Glenn P. Muir | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.29 per share. | 19 Nov 2024 | 19,000 | 32,283 (0%) | 0% | 36.3 | 689,510 | Common Stock |
| Glenn P. Muir | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Nov 2024 | 19,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.87 per share. | 10 Sep 2024 | 10,000 | 162,031 (0%) | 0% | 33.9 | 338,700 | Common Stock |
| Tony J. Hunt | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2024 | 10,000 | 24,246 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director | Sale of securities on an exchange or to another person at price $ 146.67 per share. | 10 Sep 2024 | 604 | 139,840 (0%) | 0% | 146.7 | 88,589 | Common Stock |
| Tony J. Hunt | Director | Sale of securities on an exchange or to another person at price $ 145.95 per share. | 10 Sep 2024 | 10,723 | 140,444 (0%) | 0% | 146.0 | 1,565,022 | Common Stock |
| Tony J. Hunt | Director | Sale of securities on an exchange or to another person at price $ 144.88 per share. | 10 Sep 2024 | 9,369 | 151,167 (0%) | 0% | 144.9 | 1,357,381 | Common Stock |
| Tony J. Hunt | Director | Sale of securities on an exchange or to another person at price $ 143.77 per share. | 10 Sep 2024 | 1,495 | 160,536 (0%) | 0% | 143.8 | 214,936 | Common Stock |
| Tony J. Hunt | Director | Sale or transfer of securities back to the company at price $ 0.00 per share. | 03 Sep 2024 | 13,146 | 152,031 (0%) | 0% | 0 | Common Stock | |
| Tony J. Hunt | Director | Sale or transfer of securities back to the company at price $ 0.00 per share. | 03 Sep 2024 | 13,057 | 6,528 | - | - | Stock Option (Right to Buy) | |
| Olivier Loeillot | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Sep 2024 | 16,278 | 16,278 | - | - | Stock Option (Right to Buy) | |
| Olivier Loeillot | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Sep 2024 | 17,631 | 33,417 (0%) | 0% | 0 | Common Stock | |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 86.10 per share. | 02 Aug 2024 | 175 | 12,463 (0%) | 0% | 86.1 | 15,068 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2024 | 175 | 0 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 158.85 per share. | 02 Aug 2024 | 175 | 12,288 (0%) | 0% | 158.9 | 27,799 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 159.36 per share. | 02 Aug 2024 | 6,973 | 12,288 (0%) | 0% | 159.4 | 1,111,217 | Common Stock |
| Glenn P. Muir | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 5,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Glenn P. Muir | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.29 per share. | 01 Aug 2024 | 5,000 | 13,283 (0%) | 0% | 36.3 | 181,450 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 165.67 per share. | 01 Aug 2024 | 4,465 | 19,261 (0%) | 0% | 165.7 | 739,717 | Common Stock |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2024 | 2,953 | 0 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.71 per share. | 14 Jun 2024 | 2,953 | 88,170 (0%) | 0% | 67.7 | 199,948 | Common Stock |
| Nicolas M. Barthelemy | Director | Purchase of securities on an exchange or from another person at price $ 125.45 per share. | 14 Jun 2024 | 1,200 | 4,668 (0%) | 0% | 125.5 | 150,540 | Common Stock |
| Martin D. Madaus | Director | Purchase of securities on an exchange or from another person at price $ 124.54 per share. | 14 Jun 2024 | 915 | 3,913 (0%) | 0% | 124.5 | 113,954 | Common Stock |
| Martin D. Madaus | Director | Purchase of securities on an exchange or from another person at price $ 125.46 per share. | 14 Jun 2024 | 700 | 4,613 (0%) | 0% | 125.5 | 87,822 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 124.08 per share. | 14 Jun 2024 | 2,000 | 165,177 (0%) | 0% | 124.1 | 248,160 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 166.36 per share. | 21 May 2024 | 4,274 | 178,975 (0%) | 0% | 166.4 | 711,023 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 171.03 per share. | 21 May 2024 | 969 | 163,177 (0%) | 0% | 171.0 | 165,728 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 170.04 per share. | 21 May 2024 | 3,925 | 164,146 (0%) | 0% | 170.0 | 667,407 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 169.27 per share. | 21 May 2024 | 2,963 | 168,071 (0%) | 0% | 169.3 | 501,547 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 168.33 per share. | 21 May 2024 | 3,933 | 171,034 (0%) | 0% | 168.3 | 662,042 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 167.05 per share. | 21 May 2024 | 4,008 | 174,967 (0%) | 0% | 167.0 | 669,536 | Common Stock |
| Glenn P. Muir | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 701 | 8,283 (0%) | 0% | 0 | Common Stock | |
| Glenn P. Muir | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 1,376 | 1,376 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 1,576 | 1,576 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 803 | 88,170 (0%) | 0% | 0 | Common Stock | |
| Nicolas M. Barthelemy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 701 | 3,468 (0%) | 0% | 0 | Common Stock | |
| Nicolas M. Barthelemy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 1,376 | 1,376 | - | - | Stock Option (Right to Buy) | |
| Martin D. Madaus | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 1,376 | 1,376 | - | - | Stock Option (Right to Buy) | |
| Martin D. Madaus | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 701 | 2,998 (0%) | 0% | 0 | Common Stock | |
| Carrie Eglinton Manner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 701 | 3,493 (0%) | 0% | 0 | Common Stock | |
| Carrie Eglinton Manner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 1,376 | 1,376 | - | - | Stock Option (Right to Buy) | |
| Rohin Mhatre | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 701 | 3,046 (0%) | 0% | 0 | Common Stock | |
| Rohin Mhatre | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 1,376 | 1,376 | - | - | Stock Option (Right to Buy) | |
| Konstantin Konstantinov | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 1,376 | 1,376 | - | - | Stock Option (Right to Buy) | |
| Konstantin Konstantinov | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 701 | 1,921 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Pax | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 701 | 793 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Pax | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 1,376 | 1,376 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.34 per share. | 14 May 2024 | 534 | 23,726 (0%) | 0% | 163.3 | 87,224 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.34 per share. | 14 May 2024 | 334 | 27,419 (0%) | 0% | 163.3 | 54,556 | Common Stock |
| James R. Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 182.95 per share. | 02 Apr 2024 | 444 | 20,591 (0%) | 0% | 183.0 | 81,230 | Common Stock |
| Margaret A. Pax | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2024 | 2,236 | 2,236 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Pax | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2024 | 195 | 195 | - | - | Stock Option (Right to Buy) | |
| Margaret A. Pax | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Mar 2024 | 92 | 92 (0%) | 0% | 0 | Common Stock | |
| Tony J. Hunt | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 18 Mar 2024 | 2,000 | 183,249 (0%) | 0% | 0 | Common Stock | |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2024 | 1,271 | 0 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 193.73 per share. | 11 Mar 2024 | 3,517 | 24,260 (0%) | 0% | 193.7 | 681,348 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 86.10 per share. | 11 Mar 2024 | 1,271 | 27,777 (0%) | 0% | 86.1 | 109,433 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.00 per share. | 08 Mar 2024 | 1 | 201,956 (0%) | 0% | 17 | 17 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2024 | 1 | 0 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 202.55 per share. | 08 Mar 2024 | 156 | 185,249 (0%) | 0% | 202.6 | 31,598 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 201.75 per share. | 08 Mar 2024 | 806 | 185,405 (0%) | 0% | 201.8 | 162,611 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 200.56 per share. | 08 Mar 2024 | 1,305 | 186,211 (0%) | 0% | 200.6 | 261,731 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 199.53 per share. | 08 Mar 2024 | 1,822 | 187,516 (0%) | 0% | 199.5 | 363,544 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 198.55 per share. | 08 Mar 2024 | 1,347 | 189,338 (0%) | 0% | 198.6 | 267,447 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 197.39 per share. | 08 Mar 2024 | 1,666 | 190,685 (0%) | 0% | 197.4 | 328,852 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 196.32 per share. | 08 Mar 2024 | 6,228 | 192,351 (0%) | 0% | 196.3 | 1,222,681 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 195.49 per share. | 08 Mar 2024 | 3,377 | 198,579 (0%) | 0% | 195.5 | 660,170 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 195.72 per share. | 07 Mar 2024 | 2,867 | 201,955 (0%) | 0% | 195.7 | 561,129 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 195.72 per share. | 07 Mar 2024 | 386 | 26,506 (0%) | 0% | 195.7 | 75,548 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 195.72 per share. | 07 Mar 2024 | 386 | 27,753 (0%) | 0% | 195.7 | 75,548 | Common Stock |
| James Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 195.72 per share. | 07 Mar 2024 | 1,206 | 21,035 (0%) | 0% | 195.7 | 236,038 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 195.52 per share. | 04 Mar 2024 | 7,275 | 204,822 (0%) | 0% | 195.5 | 1,422,408 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 193.99 per share. | 04 Mar 2024 | 1,111 | 212,097 (0%) | 0% | 194.0 | 215,523 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 193.99 per share. | 04 Mar 2024 | 135 | 26,892 (0%) | 0% | 194.0 | 26,189 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 193.99 per share. | 04 Mar 2024 | 131 | 28,139 (0%) | 0% | 194.0 | 25,413 | Common Stock |
| James Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 193.99 per share. | 04 Mar 2024 | 197 | 22,263 (0%) | 0% | 194.0 | 38,216 | Common Stock |
| James Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 195.50 per share. | 04 Mar 2024 | 22 | 22,241 (0%) | 0% | 195.5 | 4,301 | Common Stock |
| James Bylund | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 50 | 22,460 (0%) | 0% | 0 | Common Stock | |
| Tony J. Hunt | Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 191.79 per share. | 29 Feb 2024 | 3,322 | 213,208 (0%) | 0% | 191.8 | 637,126 | Common Stock |
| Tony J. Hunt | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Feb 2024 | 2,504 | 216,530 (0%) | 0% | 0 | Common Stock | |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 191.79 per share. | 29 Feb 2024 | 453 | 27,027 (0%) | 0% | 191.8 | 86,881 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Feb 2024 | 404 | 27,480 (0%) | 0% | 0 | Common Stock | |
| Christine Gebski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Feb 2024 | 391 | 29,178 (0%) | 0% | 0 | Common Stock | |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 192.71 per share. | 29 Feb 2024 | 461 | 28,270 (0%) | 0% | 192.7 | 88,839 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 191.79 per share. | 29 Feb 2024 | 447 | 28,731 (0%) | 0% | 191.8 | 85,730 | Common Stock |
| James Bylund | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Feb 2024 | 404 | 23,230 (0%) | 0% | 0 | Common Stock | |
| James Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 191.79 per share. | 29 Feb 2024 | 820 | 22,410 (0%) | 0% | 191.8 | 157,268 | Common Stock |
| J. Tony Hunt | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 19,585 | 19,585 | - | - | Stock Option (Right to Buy) | |
| Jason K. Garland | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 2,523 | 2,523 | - | - | Stock Option (Right to Buy) | |
| Kuriyel Ralf | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 3,520 | 27,076 (0%) | 0% | 0 | Common Stock | |
| A. Karen Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 4,626 | 0 | - | - | Stock Option (Right to Buy) | |
| Garland K. Jason | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 2,540 | 8,043 (0%) | 0% | 0 | Common Stock | |
| Tony J. Hunt | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 19,719 | 214,026 (0%) | 0% | 0 | Common Stock | |
| Bylund James | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 8,632 | 8,632 | - | - | Stock Option (Right to Buy) | |
| Dawes Karen A. | Director | Sale of securities on an exchange or to another person at price $ 193.35 per share. | 27 Feb 2024 | 1,000 | 87,367 (0%) | 0% | 193.4 | 193,350 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 3,497 | 3,497 | - | - | Stock Option (Right to Buy) | |
| Dawes Karen A. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.07 per share. | 27 Feb 2024 | 4,626 | 88,367 (0%) | 0% | 42.1 | 194,616 | Common Stock |
| Olivier Loeillot | President and CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 2,860 | 2,860 | - | - | Stock Option (Right to Buy) | |
| Olivier Loeillot | President and CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 2,880 | 15,786 (0%) | 0% | 0 | Common Stock | |
| Bylund James | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2024 | 8,691 | 22,826 (0%) | 0% | 0 | Common Stock | |
| James Bylund | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Feb 2024 | 940 | 4,000 | - | - | Stock Option (Right to Buy) | |
| Bylund James | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 198.08 per share. | 23 Feb 2024 | 4,373 | 14,135 (0%) | 0% | 198.1 | 866,204 | Common Stock |
| Bylund James | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 94.33 per share. | 23 Feb 2024 | 940 | 18,508 (0%) | 0% | 94.3 | 88,670 | Common Stock |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.12 per share. | 29 Aug 2023 | 7,392 | 84,591 (0%) | 0% | 18.1 | 133,943 | Common Stock |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Aug 2023 | 7,392 | 0 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 171.38 per share. | 29 Aug 2023 | 850 | 83,741 (0%) | 0% | 171.4 | 145,673 | Common Stock |
| Glenn P. Muir | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 686 | 7,582 (0%) | 0% | 0 | Common Stock | |
| Glenn P. Muir | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 1,487 | 1,487 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 1,730 | 1,730 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 798 | 77,199 (0%) | 0% | 0 | Common Stock | |
| Nicolas M. Barthelemy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 686 | 2,767 (0%) | 0% | 0 | Common Stock | |
| Nicolas M. Barthelemy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 1,487 | 1,487 | - | - | Stock Option (Right to Buy) | |
| Martin D. Madaus | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 1,487 | 1,487 | - | - | Stock Option (Right to Buy) | |
| Martin D. Madaus | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 686 | 2,297 (0%) | 0% | 0 | Common Stock | |
| Carrie Eglinton Manner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 686 | 2,167 (0%) | 0% | 0 | Common Stock | |
| Carrie Eglinton Manner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 1,487 | 1,487 | - | - | Stock Option (Right to Buy) | |
| Rohin Mhatre | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 1,487 | 1,487 | - | - | Stock Option (Right to Buy) | |
| Rohin Mhatre | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 686 | 2,345 (0%) | 0% | 0 | Common Stock | |
| Konstantin Konstantinov | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 1,487 | 1,487 | - | - | Stock Option (Right to Buy) | |
| Konstantin Konstantinov | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 May 2023 | 686 | 1,220 (0%) | 0% | 0 | Common Stock | |
| Jon K. Snodgres | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 154.03 per share. | 16 May 2023 | 710 | 37,381 (0%) | 0% | 154.0 | 109,361 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 154.03 per share. | 16 May 2023 | 710 | 23,556 (0%) | 0% | 154.0 | 109,361 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 154.03 per share. | 16 May 2023 | 334 | 32,575 (0%) | 0% | 154.0 | 51,446 | Common Stock |
| James Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.45 per share. | 04 Apr 2023 | 334 | 17,568 (0%) | 0% | 163.4 | 54,592 | Common Stock |
| Martin D. Madaus | Director | 24 Mar 2023 | 11 | 11 (0%) | 0% | 186.2 | 2,048 | Common Stock | |
| Martin D. Madaus | Director | Purchase of securities on an exchange or from another person at price $ 156.18 per share. | 24 Mar 2023 | 500 | 1,611 (0%) | 0% | 156.2 | 78,090 | Common Stock |
| Martin D. Madaus | Director | Purchase of securities on an exchange or from another person at price $ 159.19 per share. | 24 Mar 2023 | 500 | 1,111 (0%) | 0% | 159.2 | 79,595 | Common Stock |
| Martin D. Madaus | Director | Purchase of securities on an exchange or from another person at price $ 161.15 per share. | 24 Mar 2023 | 500 | 611 (0%) | 0% | 161.2 | 80,575 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 20,080 | 20,080 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 188.00 per share. | 02 Mar 2023 | 8,244 | 195,307 (0%) | 0% | 188 | 1,549,872 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 18,584 | 203,551 (0%) | 0% | 0 | Common Stock | |
| Tony J. Hunt | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 19,393 | 184,967 (0%) | 0% | 0 | Common Stock | |
| Jon K. Snodgres | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 4,848 | 32,970 (0%) | 0% | 0 | Common Stock | |
| Jon K. Snodgres | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 8,795 | 41,765 (0%) | 0% | 0 | Common Stock | |
| Jon K. Snodgres | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 188.00 per share. | 02 Mar 2023 | 3,674 | 38,091 (0%) | 0% | 188 | 690,712 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 5,019 | 5,019 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 3,591 | 25,513 (0%) | 0% | 0 | Common Stock | |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 3,468 | 21,922 (0%) | 0% | 0 | Common Stock | |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 3,591 | 3,591 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 188.00 per share. | 02 Mar 2023 | 1,247 | 24,266 (0%) | 0% | 188 | 234,436 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 188.00 per share. | 02 Mar 2023 | 126 | 32,909 (0%) | 0% | 188 | 23,688 | Common Stock |
| Christine Gebski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 3,467 | 32,660 (0%) | 0% | 0 | Common Stock | |
| Christine Gebski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 3,590 | 3,590 | - | - | Stock Option (Right to Buy) | |
| Christine Gebski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 375 | 33,035 (0%) | 0% | 0 | Common Stock | |
| James Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 188.00 per share. | 02 Mar 2023 | 210 | 17,902 (0%) | 0% | 188 | 39,480 | Common Stock |
| James Bylund | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 8,348 | 17,487 (0%) | 0% | 0 | Common Stock | |
| James Bylund | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 8,644 | 8,644 | - | - | Stock Option (Right to Buy) | |
| James Bylund | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 625 | 18,112 (0%) | 0% | 0 | Common Stock | |
| Tony J. Hunt | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 176.37 per share. | 28 Feb 2023 | 6,670 | 165,574 (0%) | 0% | 176.4 | 1,176,388 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 173.44 per share. | 28 Feb 2023 | 3,273 | 174,992 (0%) | 0% | 173.4 | 567,669 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 173.28 per share. | 28 Feb 2023 | 2,748 | 172,244 (0%) | 0% | 173.3 | 476,173 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 173.44 per share. | 28 Feb 2023 | 682 | 28,643 (0%) | 0% | 173.4 | 118,286 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 173.28 per share. | 28 Feb 2023 | 521 | 28,122 (0%) | 0% | 173.3 | 90,279 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 173.44 per share. | 28 Feb 2023 | 458 | 18,812 (0%) | 0% | 173.4 | 79,436 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 173.28 per share. | 28 Feb 2023 | 358 | 18,454 (0%) | 0% | 173.3 | 62,034 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 173.44 per share. | 28 Feb 2023 | 452 | 30,283 (0%) | 0% | 173.4 | 78,395 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 174.37 per share. | 28 Feb 2023 | 630 | 29,193 (0%) | 0% | 174.4 | 109,853 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 173.28 per share. | 28 Feb 2023 | 460 | 29,823 (0%) | 0% | 173.3 | 79,709 | Common Stock |
| James Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 173.44 per share. | 28 Feb 2023 | 594 | 9,139 (0%) | 0% | 173.4 | 103,023 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 200.00 per share. | 16 Feb 2023 | 5,647 | 29,325 (0%) | 0% | 200 | 1,129,400 | Common Stock |
| Martin D. Madaus | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2023 | 1,819 | 1,819 | - | - | Stock Option (Right to Buy) | |
| Martin D. Madaus | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2023 | 111 | 111 (0%) | 0% | 0 | Common Stock | |
| Martin D. Madaus | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2023 | 239 | 239 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.87 per share. | 11 Nov 2022 | 25,000 | 203,265 (0%) | 0% | 33.9 | 846,750 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 200.00 per share. | 11 Nov 2022 | 25,000 | 178,265 (0%) | 0% | 200 | 5,000,000 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Nov 2022 | 25,000 | 34,246 | - | - | Stock Option (Right to Buy) | |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.52 per share. | 07 Oct 2022 | 466 | 34,972 (0%) | 0% | 59.5 | 27,736 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Oct 2022 | 466 | 2,108 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 227.17 per share. | 09 Sep 2022 | 775 | 76,401 (0%) | 0% | 227.2 | 176,057 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 223.26 per share. | 08 Sep 2022 | 1,389 | 200,499 (0%) | 0% | 223.3 | 310,108 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 222.24 per share. | 08 Sep 2022 | 720 | 201,888 (0%) | 0% | 222.2 | 160,013 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 221.46 per share. | 08 Sep 2022 | 1,235 | 202,608 (0%) | 0% | 221.5 | 273,503 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 220.08 per share. | 08 Sep 2022 | 824 | 203,843 (0%) | 0% | 220.1 | 181,346 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.87 per share. | 08 Sep 2022 | 10,000 | 204,667 (0%) | 0% | 33.9 | 338,700 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2022 | 10,000 | 59,246 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 227.01 per share. | 08 Sep 2022 | 245 | 178,265 (0%) | 0% | 227.0 | 55,617 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 226.34 per share. | 08 Sep 2022 | 4,873 | 178,510 (0%) | 0% | 226.3 | 1,102,955 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 225.22 per share. | 08 Sep 2022 | 10,490 | 183,383 (0%) | 0% | 225.2 | 2,362,558 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 224.47 per share. | 08 Sep 2022 | 6,626 | 193,873 (0%) | 0% | 224.5 | 1,487,338 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 215.58 per share. | 16 Aug 2022 | 970 | 41,204 (0%) | 0% | 215.6 | 209,113 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2022 | 970 | 1,940 | - | - | Stock Option (Right to Buy) | |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2022 | 3,047 | 1,524 | - | - | Stock Option (Right to Buy) | |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 253.16 per share. | 16 Aug 2022 | 2,400 | 34,506 (0%) | 0% | 253.2 | 607,584 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 252.70 per share. | 16 Aug 2022 | 4,298 | 36,906 (0%) | 0% | 252.7 | 1,086,105 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 86.10 per share. | 16 Aug 2022 | 3,047 | 40,234 (0%) | 0% | 86.1 | 262,347 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 254.14 per share. | 11 Aug 2022 | 4,040 | 19,270 (0%) | 0% | 254.1 | 1,026,726 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Aug 2022 | 646 | 400 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Aug 2022 | 1,354 | 0 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Aug 2022 | 2,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 255.20 per share. | 11 Aug 2022 | 800 | 23,310 (0%) | 0% | 255.2 | 204,160 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 86.10 per share. | 11 Aug 2022 | 646 | 24,110 (0%) | 0% | 86.1 | 55,621 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.52 per share. | 11 Aug 2022 | 1,354 | 23,464 (0%) | 0% | 59.5 | 80,590 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.05 per share. | 11 Aug 2022 | 2,000 | 22,110 (0%) | 0% | 33.1 | 66,100 | Common Stock |
| Christine Gebski | See Remarks | Sale of securities on an exchange or to another person at price $ 243.01 per share. | 04 Aug 2022 | 3,357 | 30,735 (0%) | 0% | 243.0 | 815,785 | Common Stock |
| James Bylund | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2022 | 2,000 | 8,000 | - | - | Stock Option (Right to Buy) | |
| James Bylund | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 240.40 per share. | 03 Aug 2022 | 2,000 | 9,733 (0%) | 0% | 240.4 | 480,800 | Common Stock |
| James Bylund | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 94.33 per share. | 03 Aug 2022 | 2,000 | 11,733 (0%) | 0% | 94.3 | 188,660 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 220.00 per share. | 01 Aug 2022 | 2,000 | 37,187 (0%) | 0% | 220 | 440,000 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.40 per share. | 21 Jul 2022 | 15,154 | 219,469 (0%) | 0% | 32.4 | 490,990 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2022 | 15,154 | 0 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2022 | 5,000 | 69,246 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 200.00 per share. | 21 Jul 2022 | 24,802 | 194,667 (0%) | 0% | 200 | 4,960,400 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.87 per share. | 21 Jul 2022 | 5,000 | 204,315 (0%) | 0% | 33.9 | 169,350 | Common Stock |
| Glenn P. Muir | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 1,298 | 1,298 | - | - | Stock Option (Right to Buy) | |
| Glenn P. Muir | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 534 | 6,896 (0%) | 0% | 0 | Common Stock | |
| Karen A. Dawes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 644 | 77,176 (0%) | 0% | 0 | Common Stock | |
| Karen A. Dawes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 1,565 | 1,565 | - | - | Stock Option (Right to Buy) | |
| Nicolas M. Barthelemy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 534 | 2,081 (0%) | 0% | 0 | Common Stock | |
| Nicolas M. Barthelemy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 1,298 | 1,298 | - | - | Stock Option (Right to Buy) | |
| Carrie Eglinton Manner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 2,488 | 2,488 | - | - | Stock Option (Right to Buy) | |
| Carrie Eglinton Manner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 1,024 | 1,481 (0%) | 0% | 0 | Common Stock | |
| Rohin Mhatre | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 2,920 | 2,920 | - | - | Stock Option (Right to Buy) | |
| Rohin Mhatre | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 1,202 | 1,659 (0%) | 0% | 0 | Common Stock | |
| Konstantin Konstantinov | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 2,498 | 2,498 | - | - | Stock Option (Right to Buy) | |
| Konstantin Konstantinov | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 534 | 534 (0%) | 0% | 0 | Common Stock | |
| Konstantin Konstantinov | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2022 | 1,298 | 1,298 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 152.84 per share. | 25 May 2022 | 742 | 76,532 (0%) | 0% | 152.8 | 113,407 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 149.18 per share. | 25 May 2022 | 2,576 | 88,671 (0%) | 0% | 149.2 | 384,288 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 150.19 per share. | 25 May 2022 | 7,677 | 80,994 (0%) | 0% | 150.2 | 1,153,009 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 151.14 per share. | 25 May 2022 | 1,845 | 79,149 (0%) | 0% | 151.1 | 278,853 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 152.14 per share. | 25 May 2022 | 1,875 | 77,274 (0%) | 0% | 152.1 | 285,263 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 150.40 per share. | 13 May 2022 | 712 | 39,187 (0%) | 0% | 150.4 | 107,085 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 150.40 per share. | 13 May 2022 | 712 | 20,110 (0%) | 0% | 150.4 | 107,085 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 150.40 per share. | 13 May 2022 | 335 | 34,092 (0%) | 0% | 150.4 | 50,384 | Common Stock |
| James Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 188.02 per share. | 01 Apr 2022 | 335 | 9,733 (0%) | 0% | 188.0 | 62,987 | Common Stock |
| Carrie Eglinton Manner | Director | Purchase of securities on an exchange or from another person at price $ 175.02 per share. | 16 Mar 2022 | 625 | 2,106 (0%) | 0% | 175.0 | 109,388 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.52 per share. | 08 Mar 2022 | 1,214 | 39,899 (0%) | 0% | 59.5 | 72,257 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2022 | 1,214 | 2,574 | - | - | Stock Option (Right to Buy) | |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2022 | 2,952 | 13,707 | - | - | Stock Option (Right to Buy) | |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.87 per share. | 08 Mar 2022 | 2,952 | 38,685 (0%) | 0% | 33.9 | 99,984 | Common Stock |
| Thomas F. Ryan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2022 | 1,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas F. Ryan | Director | Sale of securities on an exchange or to another person at price $ 197.58 per share. | 01 Mar 2022 | 1,000 | 1,457 (0%) | 0% | 197.6 | 197,580 | Common Stock |
| Thomas F. Ryan | Director | Sale of securities on an exchange or to another person at price $ 198.48 per share. | 01 Mar 2022 | 1,000 | 2,457 (0%) | 0% | 198.5 | 198,480 | Common Stock |
| Thomas F. Ryan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.76 per share. | 01 Mar 2022 | 1,000 | 3,457 (0%) | 0% | 38.8 | 38,760 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 194.06 per share. | 01 Mar 2022 | 7,292 | 199,315 (0%) | 0% | 194.1 | 1,415,086 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2022 | 30,074 | 219,975 (0%) | 0% | 0 | Common Stock | |
| Tony J. Hunt | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 196.70 per share. | 27 Feb 2022 | 2,754 | 193,071 (0%) | 0% | 196.7 | 541,712 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 196.70 per share. | 27 Feb 2022 | 3,170 | 189,901 (0%) | 0% | 196.7 | 623,539 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 196.70 per share. | 27 Feb 2022 | 13,368 | 206,607 (0%) | 0% | 196.7 | 2,629,486 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 196.70 per share. | 27 Feb 2022 | 695 | 32,940 (0%) | 0% | 196.7 | 136,707 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 196.70 per share. | 27 Feb 2022 | 2,468 | 35,733 (0%) | 0% | 196.7 | 485,456 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2022 | 5,922 | 38,201 (0%) | 0% | 0 | Common Stock | |
| Jon K. Snodgres | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 196.70 per share. | 27 Feb 2022 | 661 | 32,279 (0%) | 0% | 196.7 | 130,019 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 196.70 per share. | 27 Feb 2022 | 477 | 18,645 (0%) | 0% | 196.7 | 93,826 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2022 | 4,234 | 22,406 (0%) | 0% | 0 | Common Stock | |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 196.70 per share. | 27 Feb 2022 | 1,584 | 20,822 (0%) | 0% | 196.7 | 311,573 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 196.70 per share. | 27 Feb 2022 | 473 | 18,172 (0%) | 0% | 196.7 | 93,039 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 196.70 per share. | 27 Feb 2022 | 598 | 34,427 (0%) | 0% | 196.7 | 117,627 | Common Stock |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 196.70 per share. | 27 Feb 2022 | 462 | 35,025 (0%) | 0% | 196.7 | 90,875 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 20,307 | 20,307 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.21 per share. | 24 Feb 2022 | 1,170 | 195,825 (0%) | 0% | 189.2 | 221,376 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 15,855 | 196,995 (0%) | 0% | 0 | Common Stock | |
| Jon K. Snodgres | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 3,443 | 33,904 (0%) | 0% | 0 | Common Stock | |
| Jon K. Snodgres | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 4,410 | 4,410 | - | - | Stock Option (Right to Buy) | |
| Jon K. Snodgres | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.21 per share. | 24 Feb 2022 | 269 | 33,635 (0%) | 0% | 189.2 | 50,897 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,723 | 2,723 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,126 | 19,310 (0%) | 0% | 0 | Common Stock | |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.21 per share. | 24 Feb 2022 | 188 | 19,122 (0%) | 0% | 189.2 | 35,571 | Common Stock |
| Christine Gebski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,124 | 35,668 (0%) | 0% | 0 | Common Stock | |
| Christine Gebski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 2,721 | 2,721 | - | - | Stock Option (Right to Buy) | |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.21 per share. | 24 Feb 2022 | 181 | 35,487 (0%) | 0% | 189.2 | 34,247 | Common Stock |
| James Bylund | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 4,312 | 4,312 | - | - | Stock Option (Right to Buy) | |
| James Bylund | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2022 | 3,366 | 10,256 (0%) | 0% | 0 | Common Stock | |
| James Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 189.21 per share. | 24 Feb 2022 | 188 | 10,068 (0%) | 0% | 189.2 | 35,571 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2022 | 900 | 30,793 (0%) | 0% | 0 | Common Stock | |
| Jon K. Snodgres | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 182.42 per share. | 17 Feb 2022 | 332 | 30,461 (0%) | 0% | 182.4 | 60,563 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 182.42 per share. | 17 Feb 2022 | 175 | 17,184 (0%) | 0% | 182.4 | 31,924 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2022 | 450 | 17,359 (0%) | 0% | 0 | Common Stock | |
| Christine Gebski | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 182.42 per share. | 17 Feb 2022 | 224 | 33,544 (0%) | 0% | 182.4 | 40,862 | Common Stock |
| Christine Gebski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2022 | 450 | 33,768 (0%) | 0% | 0 | Common Stock | |
| James Bylund | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 182.42 per share. | 17 Feb 2022 | 334 | 6,890 (0%) | 0% | 182.4 | 60,928 | Common Stock |
| James Bylund | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2022 | 900 | 7,224 (0%) | 0% | 0 | Common Stock | |
| Ralf Kuriyel | Senior VP, R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 252.53 per share. | 14 Dec 2021 | 445 | 16,909 (0%) | 0% | 252.5 | 112,376 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2021 | 10,000 | 15,154 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 281.40 per share. | 18 Nov 2021 | 596 | 182,140 (0%) | 0% | 281.4 | 167,714 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 279.08 per share. | 18 Nov 2021 | 970 | 182,736 (0%) | 0% | 279.1 | 270,708 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 278.08 per share. | 18 Nov 2021 | 6,024 | 183,706 (0%) | 0% | 278.1 | 1,675,154 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 277.01 per share. | 18 Nov 2021 | 1,732 | 189,730 (0%) | 0% | 277.0 | 479,781 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 276.20 per share. | 18 Nov 2021 | 4,017 | 191,462 (0%) | 0% | 276.2 | 1,109,495 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 274.83 per share. | 18 Nov 2021 | 1,955 | 195,479 (0%) | 0% | 274.8 | 537,293 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.40 per share. | 18 Nov 2021 | 10,000 | 199,495 (0%) | 0% | 32.4 | 324,000 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 273.91 per share. | 18 Nov 2021 | 2,061 | 197,434 (0%) | 0% | 273.9 | 564,529 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 265.27 per share. | 10 Nov 2021 | 488 | 92,351 (0%) | 0% | 265.3 | 129,452 | Common Stock |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Nov 2021 | 4,783 | 0 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 271.29 per share. | 10 Nov 2021 | 14 | 91,247 (0%) | 0% | 271.3 | 3,798 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 269.94 per share. | 10 Nov 2021 | 255 | 91,261 (0%) | 0% | 269.9 | 68,835 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 267.75 per share. | 10 Nov 2021 | 349 | 91,516 (0%) | 0% | 267.8 | 93,445 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 266.72 per share. | 10 Nov 2021 | 486 | 91,865 (0%) | 0% | 266.7 | 129,626 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 264.21 per share. | 10 Nov 2021 | 336 | 92,839 (0%) | 0% | 264.2 | 88,775 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 263.23 per share. | 10 Nov 2021 | 1,119 | 93,175 (0%) | 0% | 263.2 | 294,554 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 262.28 per share. | 10 Nov 2021 | 1,038 | 94,294 (0%) | 0% | 262.3 | 272,247 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 261.10 per share. | 10 Nov 2021 | 236 | 95,332 (0%) | 0% | 261.1 | 61,620 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 259.75 per share. | 10 Nov 2021 | 462 | 95,568 (0%) | 0% | 259.8 | 120,005 | Common Stock |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.12 per share. | 10 Nov 2021 | 4,783 | 96,030 (0%) | 0% | 26.1 | 124,932 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 304.23 per share. | 02 Nov 2021 | 124 | 92,230 (0%) | 0% | 304.2 | 37,725 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 303.48 per share. | 02 Nov 2021 | 532 | 92,354 (0%) | 0% | 303.5 | 161,451 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 301.97 per share. | 02 Nov 2021 | 446 | 92,886 (0%) | 0% | 302.0 | 134,679 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 301.20 per share. | 02 Nov 2021 | 251 | 93,332 (0%) | 0% | 301.2 | 75,601 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 299.02 per share. | 02 Nov 2021 | 64 | 93,583 (0%) | 0% | 299.0 | 19,137 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 306.49 per share. | 02 Nov 2021 | 283 | 91,247 (0%) | 0% | 306.5 | 86,737 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 305.91 per share. | 02 Nov 2021 | 700 | 91,530 (0%) | 0% | 305.9 | 214,137 | Common Stock |
| Thomas F. Ryan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Nov 2021 | 1,285 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas F. Ryan | Director | Sale of securities on an exchange or to another person at price $ 288.00 per share. | 02 Nov 2021 | 1,000 | 12,337 (0%) | 0% | 288 | 288,000 | Common Stock |
| Thomas F. Ryan | Director | Sale of securities on an exchange or to another person at price $ 302.00 per share. | 02 Nov 2021 | 1,285 | 13,337 (0%) | 0% | 302 | 388,070 | Common Stock |
| Thomas F. Ryan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 128.18 per share. | 02 Nov 2021 | 1,285 | 14,622 (0%) | 0% | 128.2 | 164,711 | Common Stock |
| Nicolas M. Barthelemy | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 128.18 per share. | 29 Oct 2021 | 1,285 | 3,192 (0%) | 0% | 128.2 | 164,711 | Common Stock |
| Nicolas M. Barthelemy | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Oct 2021 | 1,285 | 0 | - | - | Stock Option (Right to Buy) | |
| Nicolas M. Barthelemy | Director | Sale of securities on an exchange or to another person at price $ 288.19 per share. | 29 Oct 2021 | 360 | 1,547 (0%) | 0% | 288.2 | 103,748 | Common Stock |
| Nicolas M. Barthelemy | Director | Sale of securities on an exchange or to another person at price $ 288.20 per share. | 29 Oct 2021 | 1,285 | 1,907 (0%) | 0% | 288.2 | 370,337 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 294.06 per share. | 14 Sep 2021 | 101 | 93,782 (0%) | 0% | 294.1 | 29,700 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 290.00 per share. | 14 Sep 2021 | 13 | 93,908 (0%) | 0% | 290 | 3,770 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 295.81 per share. | 14 Sep 2021 | 27 | 93,647 (0%) | 0% | 295.8 | 7,987 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 295.02 per share. | 14 Sep 2021 | 108 | 93,674 (0%) | 0% | 295.0 | 31,862 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 292.36 per share. | 14 Sep 2021 | 25 | 93,883 (0%) | 0% | 292.4 | 7,309 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Sep 2021 | 25,000 | 25,154 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 296.62 per share. | 09 Sep 2021 | 8 | 189,495 (0%) | 0% | 296.6 | 2,373 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 296.09 per share. | 09 Sep 2021 | 1,631 | 189,503 (0%) | 0% | 296.1 | 482,923 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 294.90 per share. | 09 Sep 2021 | 14,825 | 191,134 (0%) | 0% | 294.9 | 4,371,893 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 294.22 per share. | 09 Sep 2021 | 8,536 | 205,959 (0%) | 0% | 294.2 | 2,511,462 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.40 per share. | 09 Sep 2021 | 25,000 | 214,495 (0%) | 0% | 32.4 | 810,000 | Common Stock |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.76 per share. | 01 Sep 2021 | 3,459 | 97,380 (0%) | 0% | 38.8 | 134,071 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 281.68 per share. | 01 Sep 2021 | 196 | 96,945 (0%) | 0% | 281.7 | 55,209 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 280.27 per share. | 01 Sep 2021 | 239 | 97,141 (0%) | 0% | 280.3 | 66,985 | Common Stock |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Sep 2021 | 3,459 | 0 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 285.44 per share. | 01 Sep 2021 | 851 | 93,921 (0%) | 0% | 285.4 | 242,909 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 284.64 per share. | 01 Sep 2021 | 1,107 | 94,772 (0%) | 0% | 284.6 | 315,096 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 283.56 per share. | 01 Sep 2021 | 661 | 95,879 (0%) | 0% | 283.6 | 187,433 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 282.53 per share. | 01 Sep 2021 | 405 | 96,540 (0%) | 0% | 282.5 | 114,425 | Common Stock |
| Christine Gebski | See Remarks | Sale of securities on an exchange or to another person at price $ 285.33 per share. | 01 Sep 2021 | 3,377 | 33,318 (0%) | 0% | 285.3 | 963,559 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 282.13 per share. | 30 Aug 2021 | 4,001 | 17,354 (0%) | 0% | 282.1 | 1,128,802 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 256.43 per share. | 17 Aug 2021 | 194 | 95,363 (0%) | 0% | 256.4 | 49,747 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 262.30 per share. | 17 Aug 2021 | 40 | 93,921 (0%) | 0% | 262.3 | 10,492 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 260.91 per share. | 17 Aug 2021 | 78 | 93,961 (0%) | 0% | 260.9 | 20,351 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 259.93 per share. | 17 Aug 2021 | 388 | 94,039 (0%) | 0% | 259.9 | 100,853 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 258.91 per share. | 17 Aug 2021 | 634 | 94,427 (0%) | 0% | 258.9 | 164,149 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 257.66 per share. | 17 Aug 2021 | 302 | 95,061 (0%) | 0% | 257.7 | 77,813 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 255.07 per share. | 17 Aug 2021 | 2,231 | 95,557 (0%) | 0% | 255.1 | 569,061 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 254.09 per share. | 17 Aug 2021 | 8,580 | 97,788 (0%) | 0% | 254.1 | 2,180,092 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 253.34 per share. | 17 Aug 2021 | 4,665 | 106,368 (0%) | 0% | 253.3 | 1,181,831 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 251.92 per share. | 17 Aug 2021 | 920 | 111,033 (0%) | 0% | 251.9 | 231,766 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 251.15 per share. | 17 Aug 2021 | 924 | 111,953 (0%) | 0% | 251.2 | 232,063 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Aug 2021 | 1,000 | 189,495 (0%) | 0% | 0 | Common Stock | |
| Thomas F. Ryan | Director | Sale of securities on an exchange or to another person at price $ 250.50 per share. | 04 Aug 2021 | 780 | 971 (0%) | 0% | 250.5 | 195,390 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 200.01 per share. | 20 Jul 2021 | 288 | 117,174 (0%) | 0% | 200.0 | 57,603 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 203.11 per share. | 20 Jul 2021 | 614 | 112,877 (0%) | 0% | 203.1 | 124,710 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 202.29 per share. | 20 Jul 2021 | 2,877 | 113,491 (0%) | 0% | 202.3 | 581,988 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 201.37 per share. | 20 Jul 2021 | 806 | 116,368 (0%) | 0% | 201.4 | 162,304 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 202.29 per share. | 13 Jul 2021 | 630 | 117,911 (0%) | 0% | 202.3 | 127,443 | Common Stock |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 41.19 per share. | 13 Jul 2021 | 2,929 | 118,982 (0%) | 0% | 41.2 | 120,646 | Common Stock |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jul 2021 | 2,929 | 0 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 204.00 per share. | 13 Jul 2021 | 5 | 117,462 (0%) | 0% | 204 | 1,020 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 203.09 per share. | 13 Jul 2021 | 444 | 117,467 (0%) | 0% | 203.1 | 90,172 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 201.27 per share. | 13 Jul 2021 | 441 | 118,541 (0%) | 0% | 201.3 | 88,760 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 189.19 per share. | 10 Jun 2021 | 6,802 | 21,355 (0%) | 0% | 189.2 | 1,286,870 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.52 per share. | 10 Jun 2021 | 2,557 | 27,112 (0%) | 0% | 59.5 | 152,193 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2021 | 1,045 | 2,092 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2021 | 2,557 | 1,354 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 86.10 per share. | 10 Jun 2021 | 1,045 | 28,157 (0%) | 0% | 86.1 | 89,975 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 171.32 per share. | 19 May 2021 | 3,420 | 198,290 (0%) | 0% | 171.3 | 585,914 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 168.29 per share. | 19 May 2021 | 612 | 212,150 (0%) | 0% | 168.3 | 102,993 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 169.45 per share. | 19 May 2021 | 2,529 | 209,621 (0%) | 0% | 169.4 | 428,539 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 170.28 per share. | 19 May 2021 | 7,911 | 201,710 (0%) | 0% | 170.3 | 1,347,085 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 172.52 per share. | 19 May 2021 | 3,036 | 195,254 (0%) | 0% | 172.5 | 523,771 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 173.19 per share. | 19 May 2021 | 1,560 | 193,694 (0%) | 0% | 173.2 | 270,176 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 174.41 per share. | 19 May 2021 | 2,819 | 190,875 (0%) | 0% | 174.4 | 491,662 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 175.15 per share. | 19 May 2021 | 380 | 190,495 (0%) | 0% | 175.2 | 66,557 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 172.60 per share. | 14 May 2021 | 470 | 31,893 (0%) | 0% | 172.6 | 81,122 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 172.29 per share. | 14 May 2021 | 710 | 24,555 (0%) | 0% | 172.3 | 122,326 | Common Stock |
| Christine Gebski | See Remarks | Sale of securities on an exchange or to another person at price $ 172.25 per share. | 14 May 2021 | 445 | 36,695 (0%) | 0% | 172.2 | 76,651 | Common Stock |
| Glenn P. Muir | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 457 | 6,362 (0%) | 0% | 0 | Common Stock | |
| Glenn P. Muir | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 1,151 | 1,151 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 604 | 116,053 (0%) | 0% | 0 | Common Stock | |
| Karen A. Dawes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 1,522 | 1,522 | - | - | Stock Option (Right to Buy) | |
| Nicolas M. Barthelemy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 1,151 | 1,151 | - | - | Stock Option (Right to Buy) | |
| Nicolas M. Barthelemy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 457 | 1,907 (0%) | 0% | 0 | Common Stock | |
| Thomas F. Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 1,151 | 1,151 | - | - | Stock Option (Right to Buy) | |
| Thomas F. Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 457 | 1,751 (0%) | 0% | 0 | Common Stock | |
| Carrie Eglinton Manner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 457 | 457 (0%) | 0% | 0 | Common Stock | |
| Carrie Eglinton Manner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 1,151 | 1,151 | - | - | Stock Option (Right to Buy) | |
| Rohin Mhatre | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 1,151 | 1,151 | - | - | Stock Option (Right to Buy) | |
| Rohin Mhatre | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2021 | 457 | 457 (0%) | 0% | 0 | Common Stock | |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share. | 11 May 2021 | 15,000 | 115,734 (0%) | 0% | 3.2 | 48,300 | Common Stock |
| Karen A. Dawes | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2021 | 15,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 176.85 per share. | 11 May 2021 | 285 | 115,449 (0%) | 0% | 176.8 | 50,402 | Common Stock |
| James Bylund | SVP, Global Operations & IT | Sale of securities on an exchange or to another person at price $ 204.25 per share. | 06 Apr 2021 | 360 | 6,324 (0%) | 0% | 204.3 | 73,530 | Common Stock |
| Christine Gebski | See Remarks | Sale of securities on an exchange or to another person at price $ 196.88 per share. | 16 Mar 2021 | 1,400 | 37,140 (0%) | 0% | 196.9 | 275,632 | Common Stock |
| Thomas F. Ryan | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Mar 2021 | 170 | 1,294 (0%) | 0% | 0 | Common Stock | |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 188.77 per share. | 12 Mar 2021 | 1,171 | 219,779 (0%) | 0% | 188.8 | 221,050 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 194.08 per share. | 12 Mar 2021 | 235 | 212,762 (0%) | 0% | 194.1 | 45,609 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 193.30 per share. | 12 Mar 2021 | 227 | 212,997 (0%) | 0% | 193.3 | 43,879 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 192.17 per share. | 12 Mar 2021 | 1,378 | 213,224 (0%) | 0% | 192.2 | 264,810 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 191.19 per share. | 12 Mar 2021 | 1,081 | 214,602 (0%) | 0% | 191.2 | 206,676 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 190.17 per share. | 12 Mar 2021 | 4,096 | 215,683 (0%) | 0% | 190.2 | 778,936 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 188.06 per share. | 12 Mar 2021 | 914 | 220,950 (0%) | 0% | 188.1 | 171,887 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.52 per share. | 10 Mar 2021 | 150 | 33,265 (0%) | 0% | 59.5 | 8,928 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.87 per share. | 10 Mar 2021 | 5,850 | 33,115 (0%) | 0% | 33.9 | 198,140 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.05 per share. | 10 Mar 2021 | 2,000 | 27,265 (0%) | 0% | 33.1 | 66,100 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2021 | 150 | 3,911 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2021 | 5,850 | 0 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2021 | 2,000 | 2,000 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 192.13 per share. | 10 Mar 2021 | 1,004 | 25,265 (0%) | 0% | 192.1 | 192,899 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 191.33 per share. | 10 Mar 2021 | 642 | 26,269 (0%) | 0% | 191.3 | 122,834 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 190.08 per share. | 10 Mar 2021 | 6,354 | 26,911 (0%) | 0% | 190.1 | 1,207,768 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 194.43 per share. | 04 Mar 2021 | 2,125 | 239,302 (0%) | 0% | 194.4 | 413,164 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 185.22 per share. | 04 Mar 2021 | 1,633 | 221,864 (0%) | 0% | 185.2 | 302,464 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 185.91 per share. | 04 Mar 2021 | 4,746 | 223,497 (0%) | 0% | 185.9 | 882,329 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 186.90 per share. | 04 Mar 2021 | 4,271 | 228,243 (0%) | 0% | 186.9 | 798,250 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 187.48 per share. | 04 Mar 2021 | 595 | 232,514 (0%) | 0% | 187.5 | 111,551 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 193.45 per share. | 04 Mar 2021 | 6,193 | 233,109 (0%) | 0% | 193.5 | 1,198,036 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 195.54 per share. | 04 Mar 2021 | 1,082 | 241,427 (0%) | 0% | 195.5 | 211,574 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 196.44 per share. | 04 Mar 2021 | 461 | 242,509 (0%) | 0% | 196.4 | 90,559 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 197.94 per share. | 04 Mar 2021 | 794 | 242,970 (0%) | 0% | 197.9 | 157,164 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 190.45 per share. | 04 Mar 2021 | 603 | 32,963 (0%) | 0% | 190.4 | 114,841 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 191.43 per share. | 04 Mar 2021 | 500 | 33,566 (0%) | 0% | 191.4 | 95,715 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 192.54 per share. | 04 Mar 2021 | 900 | 34,066 (0%) | 0% | 192.5 | 173,286 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 193.72 per share. | 04 Mar 2021 | 242 | 34,966 (0%) | 0% | 193.7 | 46,880 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 196.30 per share. | 04 Mar 2021 | 500 | 35,208 (0%) | 0% | 196.3 | 98,150 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 197.86 per share. | 04 Mar 2021 | 200 | 35,708 (0%) | 0% | 197.9 | 39,572 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 189.75 per share. | 04 Mar 2021 | 600 | 32,363 (0%) | 0% | 189.8 | 113,850 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 196.23 per share. | 04 Mar 2021 | 400 | 26,940 (0%) | 0% | 196.2 | 78,492 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 190.06 per share. | 04 Mar 2021 | 700 | 25,265 (0%) | 0% | 190.1 | 133,042 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 191.20 per share. | 04 Mar 2021 | 600 | 25,965 (0%) | 0% | 191.2 | 114,720 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 192.24 per share. | 04 Mar 2021 | 350 | 26,565 (0%) | 0% | 192.2 | 67,284 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 194.32 per share. | 04 Mar 2021 | 25 | 26,915 (0%) | 0% | 194.3 | 4,858 | Common Stock |
| Thomas F. Ryan | Director | Sale of securities on an exchange or to another person at price $ 205.00 per share. | 03 Mar 2021 | 1,000 | 1,464 (0%) | 0% | 205 | 205,000 | Common Stock |
| Thomas F. Ryan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2021 | 1,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas F. Ryan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.12 per share. | 03 Mar 2021 | 1,000 | 2,464 (0%) | 0% | 26.1 | 26,120 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 12,601 | 12,601 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 10,437 | 243,764 (0%) | 0% | 0 | Common Stock | |
| Jon K. Snodgres | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 2,410 | 35,908 (0%) | 0% | 0 | Common Stock | |
| Jon K. Snodgres | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 2,910 | 2,910 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 1,686 | 27,340 (0%) | 0% | 0 | Common Stock | |
| Ralf Kuriyel | Senior VP, R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 2,035 | 2,035 | - | - | Stock Option (Right to Buy) | |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jan 2021 | 4,000 | 6,887 | - | - | Stock Option (Right to Buy) | |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.87 per share. | 25 Jan 2021 | 4,000 | 33,498 (0%) | 0% | 33.9 | 135,480 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 195.16 per share. | 04 Jan 2021 | 571 | 29,557 (0%) | 0% | 195.2 | 111,436 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 188.69 per share. | 04 Jan 2021 | 656 | 32,799 (0%) | 0% | 188.7 | 123,781 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 190.09 per share. | 04 Jan 2021 | 1,333 | 31,466 (0%) | 0% | 190.1 | 253,390 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 193.88 per share. | 04 Jan 2021 | 218 | 30,128 (0%) | 0% | 193.9 | 42,266 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 192.74 per share. | 04 Jan 2021 | 918 | 30,346 (0%) | 0% | 192.7 | 176,935 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 190.50 per share. | 04 Jan 2021 | 202 | 31,264 (0%) | 0% | 190.5 | 38,481 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 195.76 per share. | 04 Jan 2021 | 59 | 29,498 (0%) | 0% | 195.8 | 11,550 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 186.18 per share. | 16 Dec 2020 | 435 | 25,654 (0%) | 0% | 186.2 | 80,988 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Nov 2020 | 20,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.05 per share. | 19 Nov 2020 | 20,000 | 253,327 (0%) | 0% | 26.1 | 521,000 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 186.50 per share. | 19 Nov 2020 | 6,300 | 234,757 (0%) | 0% | 186.5 | 1,174,950 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 185.67 per share. | 19 Nov 2020 | 6,823 | 241,057 (0%) | 0% | 185.7 | 1,266,826 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 184.69 per share. | 19 Nov 2020 | 5,447 | 247,880 (0%) | 0% | 184.7 | 1,006,006 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 187.60 per share. | 19 Nov 2020 | 1,430 | 233,327 (0%) | 0% | 187.6 | 268,268 | Common Stock |
| Thomas F. Ryan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.76 per share. | 11 Nov 2020 | 934 | 2,398 (0%) | 0% | 38.8 | 36,202 | Common Stock |
| Thomas F. Ryan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Nov 2020 | 934 | 1,000 | - | - | Stock Option (Right to Buy) | |
| Thomas F. Ryan | Director | Sale of securities on an exchange or to another person at price $ 187.73 per share. | 11 Nov 2020 | 934 | 1,464 (0%) | 0% | 187.7 | 175,340 | Common Stock |
| Nicolas M. Barthelemy | Director | Sale of securities on an exchange or to another person at price $ 195.51 per share. | 09 Nov 2020 | 1,214 | 1,450 (0%) | 0% | 195.5 | 237,349 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.52 per share. | 09 Nov 2020 | 1,893 | 33,455 (0%) | 0% | 59.5 | 112,671 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Nov 2020 | 3,086 | 0 | - | - | Stock Option (Right to Buy) | |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Nov 2020 | 1,893 | 3,788 | - | - | Stock Option (Right to Buy) | |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 193.00 per share. | 09 Nov 2020 | 3,086 | 33,455 (0%) | 0% | 193 | 595,598 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.40 per share. | 09 Nov 2020 | 3,086 | 36,541 (0%) | 0% | 32.4 | 99,986 | Common Stock |
| Jon K. Snodgres | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 194.69 per share. | 09 Nov 2020 | 705 | 31,562 (0%) | 0% | 194.7 | 137,256 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 146.85 per share. | 10 Sep 2020 | 4,856 | 273,822 (0%) | 0% | 146.9 | 713,104 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2020 | 45,351 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 149.30 per share. | 10 Sep 2020 | 2,397 | 233,327 (0%) | 0% | 149.3 | 357,872 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 148.56 per share. | 10 Sep 2020 | 26,966 | 235,724 (0%) | 0% | 148.6 | 4,006,069 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 147.68 per share. | 10 Sep 2020 | 11,132 | 262,690 (0%) | 0% | 147.7 | 1,643,974 | Common Stock |
| Tony J. Hunt | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.05 per share. | 10 Sep 2020 | 45,351 | 278,678 (0%) | 0% | 26.1 | 1,181,394 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Sale of securities on an exchange or to another person at price $ 153.79 per share. | 06 Aug 2020 | 5,000 | 26,089 (0%) | 0% | 153.8 | 768,950 | Common Stock |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2020 | 5,000 | 5,850 | - | - | Stock Option (Right to Buy) | |
| Ralf Kuriyel | Senior VP, R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.87 per share. | 06 Aug 2020 | 5,000 | 31,089 (0%) | 0% | 33.9 | 169,350 | Common Stock |
| Thomas F. Ryan | Director | Sale of securities on an exchange or to another person at price $ 151.96 per share. | 31 Jul 2020 | 2,109 | 2,450 (0%) | 0% | 152.0 | 320,484 | Common Stock |
| Thomas F. Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jul 2020 | 2,109 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas F. Ryan | Director | Sale of securities on an exchange or to another person at price $ 151.77 per share. | 31 Jul 2020 | 986 | 1,464 (0%) | 0% | 151.8 | 149,645 | Common Stock |
| Thomas F. Ryan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.71 per share. | 31 Jul 2020 | 2,109 | 4,559 (0%) | 0% | 67.7 | 142,800 | Common Stock |
| Karen A. Dawes | Director | Sale of securities on an exchange or to another person at price $ 113.58 per share. | 18 Jun 2020 | 2,677 | 116,762 (0%) | 0% | 113.6 | 304,054 | Common Stock |