845.4K XNAS Volume
XNAS 17 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Arthur Frederick Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 1,958 | 1,958 | - | - | Non-Qualified Stock Option (right to buy) | |
| Arthur Frederick Ryan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 166 | 17,748 (0%) | 0% | 0 | Common Stock | |
| Joseph L. Goldstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 1,958 | 1,958 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph L. Goldstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 166 | 6,548 (0%) | 0% | 0 | Common Stock | |
| N. Anthony Coles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 1,958 | 1,958 | - | - | Non-Qualified Stock Option (right to buy) | |
| N. Anthony Coles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 166 | 1,559 (0%) | 0% | 0 | Common Stock | |
| Michael S. Brown | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 166 | 1,548 (0%) | 0% | 0 | Common Stock | |
| Michael S. Brown | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 1,958 | 1,958 | - | - | Non-Qualified Stock Option (right to buy) | |
| Craig B. Thompson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 166 | 620 (0%) | 0% | 0 | Common Stock | |
| Craig B. Thompson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 1,958 | 1,958 | - | - | Non-Qualified Stock Option (right to buy) | |
| Christine A. Poon | Director | 02 Jan 2025 | 14 | 2,186 (0%) | 0% | 0 | Common Stock | ||
| Christine A. Poon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 166 | 2,352 (0%) | 0% | 0 | Common Stock | |
| Christine A. Poon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 1,958 | 1,958 | - | - | Non-Qualified Stock Option (right to buy) | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 1,958 | 1,958 | - | - | Non-Qualified Stock Option (right to buy) | |
| David P. Schenkein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 166 | 448 (0%) | 0% | 0 | Common Stock | |
| Bonnie L. Bassler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 1,958 | 1,958 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bonnie L. Bassler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 166 | 1,548 (0%) | 0% | 0 | Common Stock | |
| Huda Y. Zoghbi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 166 | 1,548 (0%) | 0% | 0 | Common Stock | |
| Huda Y. Zoghbi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 1,958 | 1,958 | - | - | Non-Qualified Stock Option (right to buy) | |
| Kathryn Guarini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 166 | 448 (0%) | 0% | 0 | Common Stock | |
| Kathryn Guarini | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 1,958 | 1,958 | - | - | Non-Qualified Stock Option (right to buy) | |
| George L. Sing | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 413.33 per share. | 31 Dec 2024 | 3,338 | 29,610 (0%) | 0% | 413.3 | 1,379,696 | Common Stock |
| George L. Sing | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 1,958 | 1,958 | - | - | Non-Qualified Stock Option (right to buy) | |
| George L. Sing | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Dec 2024 | 3,338 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| George L. Sing | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2024 | 166 | 27,828 (0%) | 0% | 0 | Common Stock | |
| George L. Sing | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 708.19 per share. | 31 Dec 2024 | 1,948 | 27,662 (0%) | 0% | 708.2 | 1,379,554 | Common Stock |
| Marion McCourt | EVP Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 730.81 per share. | 16 Dec 2024 | 759 | 14,230 (0%) | 0% | 730.8 | 554,685 | Common Stock |
| J. Joseph Larosa | EVP General Counsel and Secret | Payment of exercise price or tax liability using portion of securities received from the company at price $ 730.81 per share. | 16 Dec 2024 | 702 | 30,075 (0%) | 0% | 730.8 | 513,029 | Common Stock |
| P. Van Plew Daniel | EVP & General Mgr, Industrial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 730.81 per share. | 16 Dec 2024 | 969 | 34,792 (0%) | 0% | 730.8 | 708,155 | Common Stock |
| J Murphy Andrew | EVP Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 730.81 per share. | 16 Dec 2024 | 1,054 | 49,074 (0%) | 0% | 730.8 | 770,274 | Common Stock |
| R. Fenimore Christopher | SVP Finance & CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 730.81 per share. | 16 Dec 2024 | 491 | 16,265 (0%) | 0% | 730.8 | 358,828 | Common Stock |
| Jason Pitofsky | VP Controller | Payment of exercise price or tax liability using portion of securities received from the company at price $ 730.81 per share. | 16 Dec 2024 | 298 | 4,664 (0%) | 0% | 730.8 | 217,781 | Common Stock |
| Neil Stahl | EVP Research and Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 730.81 per share. | 16 Dec 2024 | 304 | 48,829 (0%) | 0% | 730.8 | 222,166 | Common Stock |
| Neil Stahl | EVP Research and Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 787.00 per share. | 09 Dec 2024 | 466 | 49,133 (0%) | 0% | 787 | 366,742 | Common Stock |
| Joseph J. Larosa | EVP General Counsel and Secret | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 2,332 | 31,269 (0%) | 0% | 0 | Common Stock | |
| Joseph J. Larosa | EVP General Counsel and Secret | Payment of exercise price or tax liability using portion of securities received from the company at price $ 787.00 per share. | 06 Dec 2024 | 492 | 30,777 (0%) | 0% | 787 | 387,204 | Common Stock |
| Joseph J. Larosa | EVP General Counsel and Secret | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 8,981 | 8,981 | - | - | Non-Qualified Stock Option (right to buy) | |
| Daniel P. Van Plew | EVP & General Mgr, Industrial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 787.00 per share. | 06 Dec 2024 | 492 | 35,761 (0%) | 0% | 787 | 387,204 | Common Stock |
| Daniel P. Van Plew | EVP & General Mgr, Industrial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 3,499 | 36,253 (0%) | 0% | 0 | Common Stock | |
| Daniel P. Van Plew | EVP & General Mgr, Industrial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 13,472 | 13,472 | - | - | Non-Qualified Stock Option (right to buy) | |
| Marion McCourt | EVP Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 787.00 per share. | 06 Dec 2024 | 274 | 14,989 (0%) | 0% | 787 | 215,638 | Common Stock |
| Marion McCourt | EVP Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 2,332 | 15,263 (0%) | 0% | 0 | Common Stock | |
| Marion McCourt | EVP Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 8,981 | 8,981 | - | - | Non-Qualified Stock Option (right to buy) | |
| Christopher R. Fenimore | SVP Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 9,979 | 9,979 | - | - | Non-Qualified Stock Option (right to buy) | |
| Christopher R. Fenimore | SVP Finance & CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 787.00 per share. | 06 Dec 2024 | 1,140 | 16,756 (0%) | 0% | 787 | 897,180 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 2,591 | 17,896 (0%) | 0% | 0 | Common Stock | |
| Andrew J Murphy | EVP Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 787.00 per share. | 06 Dec 2024 | 492 | 50,128 (0%) | 0% | 787 | 387,204 | Common Stock |
| Andrew J Murphy | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 13,472 | 13,472 | - | - | Non-Qualified Stock Option (right to buy) | |
| Andrew J Murphy | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 3,499 | 50,620 (0%) | 0% | 0 | Common Stock | |
| Jason Pitofsky | VP Controller | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 3,236 | 3,236 | - | - | Non-Qualified Stock Option (right to buy) | |
| Jason Pitofsky | VP Controller | Gift of securities by or to the insider at price $ 0.00 per share. | 06 Dec 2024 | 90 | 179 (0%) | 0% | 0 | Common Stock | |
| Jason Pitofsky | VP Controller | Gift of securities by or to the insider at price $ 0.00 per share. | 06 Dec 2024 | 89 | 89 (0%) | 0% | 0 | Common Stock | |
| Jason Pitofsky | VP Controller | Payment of exercise price or tax liability using portion of securities received from the company at price $ 787.00 per share. | 06 Dec 2024 | 149 | 4,962 (0%) | 0% | 787 | 117,263 | Common Stock |
| Jason Pitofsky | VP Controller | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 907 | 5,111 (0%) | 0% | 0 | Common Stock | |
| Andrew J Murphy | EVP Research | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Nov 2024 | 1,185 | 47,121 (0%) | 0% | 0 | Common Stock | |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 1,000 | 6,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 381.40 per share. | 01 Nov 2024 | 1,000 | 13,931 (0%) | 0% | 381.4 | 381,400 | Common Stock |
| Marion McCourt | EVP Commercial | Sale of securities on an exchange or to another person at price $ 844.61 per share. | 01 Nov 2024 | 1,000 | 12,931 (0%) | 0% | 844.6 | 844,610 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1057.50 per share. | 01 Oct 2024 | 2 | 17,584 (0%) | 0% | 1057.5 | 2,115 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1052.50 per share. | 01 Oct 2024 | 4 | 17,596 (0%) | 0% | 1052.5 | 4,210 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1050.67 per share. | 01 Oct 2024 | 6 | 17,609 (0%) | 0% | 1050.7 | 6,304 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1049.67 per share. | 01 Oct 2024 | 9 | 17,615 (0%) | 0% | 1049.7 | 9,447 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1048.50 per share. | 01 Oct 2024 | 12 | 17,624 (0%) | 0% | 1048.5 | 12,582 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1047.42 per share. | 01 Oct 2024 | 12 | 17,636 (0%) | 0% | 1047.4 | 12,569 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1046.56 per share. | 01 Oct 2024 | 9 | 17,648 (0%) | 0% | 1046.6 | 9,419 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1045.29 per share. | 01 Oct 2024 | 7 | 17,657 (0%) | 0% | 1045.3 | 7,317 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1044.67 per share. | 01 Oct 2024 | 9 | 17,664 (0%) | 0% | 1044.7 | 9,402 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1053.50 per share. | 01 Oct 2024 | 4 | 17,592 (0%) | 0% | 1053.5 | 4,214 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1043.40 per share. | 01 Oct 2024 | 5 | 17,673 (0%) | 0% | 1043.4 | 5,217 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1042.00 per share. | 01 Oct 2024 | 1 | 17,678 (0%) | 0% | 1042 | 1,042 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1041.33 per share. | 01 Oct 2024 | 3 | 17,679 (0%) | 0% | 1041.3 | 3,124 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1051.56 per share. | 01 Oct 2024 | 9 | 17,600 (0%) | 0% | 1051.6 | 9,464 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1055.00 per share. | 01 Oct 2024 | 3 | 17,589 (0%) | 0% | 1055 | 3,165 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1056.67 per share. | 01 Oct 2024 | 3 | 17,586 (0%) | 0% | 1056.7 | 3,170 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1059.50 per share. | 01 Oct 2024 | 2 | 17,582 (0%) | 0% | 1059.5 | 2,119 | Common Stock |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 1,000 | 7,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Marion McCourt | EVP Commercial | Sale of securities on an exchange or to another person at price $ 1054.06 per share. | 01 Oct 2024 | 1,000 | 12,931 (0%) | 0% | 1054.1 | 1,054,060 | Common Stock |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 381.40 per share. | 01 Oct 2024 | 1,000 | 13,931 (0%) | 0% | 381.4 | 381,400 | Common Stock |
| George L. Sing | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Sep 2024 | 1,200 | 26,272 (0%) | 0% | 0 | Common Stock | |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1188.50 per share. | 03 Sep 2024 | 4 | 17,692 (0%) | 0% | 1188.5 | 4,754 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1188.00 per share. | 03 Sep 2024 | 3 | 17,696 (0%) | 0% | 1188 | 3,564 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1186.20 per share. | 03 Sep 2024 | 5 | 17,699 (0%) | 0% | 1186.2 | 5,931 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1185.75 per share. | 03 Sep 2024 | 4 | 17,704 (0%) | 0% | 1185.8 | 4,743 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1184.00 per share. | 03 Sep 2024 | 1 | 17,708 (0%) | 0% | 1184 | 1,184 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1183.50 per share. | 03 Sep 2024 | 8 | 17,709 (0%) | 0% | 1183.5 | 9,468 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1179.62 per share. | 03 Sep 2024 | 8 | 17,717 (0%) | 0% | 1179.6 | 9,437 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1178.75 per share. | 03 Sep 2024 | 4 | 17,725 (0%) | 0% | 1178.8 | 4,715 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1177.75 per share. | 03 Sep 2024 | 4 | 17,729 (0%) | 0% | 1177.8 | 4,711 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1176.75 per share. | 03 Sep 2024 | 4 | 17,733 (0%) | 0% | 1176.8 | 4,707 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1175.62 per share. | 03 Sep 2024 | 8 | 17,737 (0%) | 0% | 1175.6 | 9,405 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1174.38 per share. | 03 Sep 2024 | 8 | 17,745 (0%) | 0% | 1174.4 | 9,395 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1172.75 per share. | 03 Sep 2024 | 16 | 17,753 (0%) | 0% | 1172.8 | 18,764 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1170.50 per share. | 03 Sep 2024 | 4 | 17,769 (0%) | 0% | 1170.5 | 4,682 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1169.00 per share. | 03 Sep 2024 | 4 | 17,773 (0%) | 0% | 1169 | 4,676 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1166.50 per share. | 03 Sep 2024 | 4 | 17,778 (0%) | 0% | 1166.5 | 4,666 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1167.00 per share. | 03 Sep 2024 | 1 | 17,777 (0%) | 0% | 1167 | 1,167 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1191.00 per share. | 03 Sep 2024 | 4 | 17,682 (0%) | 0% | 1191 | 4,764 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1190.00 per share. | 03 Sep 2024 | 1 | 17,686 (0%) | 0% | 1190 | 1,190 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1189.20 per share. | 03 Sep 2024 | 5 | 17,687 (0%) | 0% | 1189.2 | 5,946 | Common Stock |
| Marion McCourt | EVP Commercial | Sale of securities on an exchange or to another person at price $ 1178.73 per share. | 03 Sep 2024 | 1,000 | 12,931 (0%) | 0% | 1178.7 | 1,178,730 | Common Stock |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 1,000 | 8,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 381.40 per share. | 03 Sep 2024 | 1,000 | 13,931 (0%) | 0% | 381.4 | 381,400 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 1206.67 per share. | 28 Aug 2024 | 200 | 25 (0%) | 0% | 1206.7 | 241,334 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 1205.67 per share. | 28 Aug 2024 | 235 | 225 (0%) | 0% | 1205.7 | 283,332 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 1206.70 per share. | 28 Aug 2024 | 200 | 25 (0%) | 0% | 1206.7 | 241,340 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 1205.67 per share. | 28 Aug 2024 | 236 | 225 (0%) | 0% | 1205.7 | 284,538 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 1206.15 per share. | 28 Aug 2024 | 450 | 0 (0%) | 0% | 1206.2 | 542,768 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 1205.49 per share. | 28 Aug 2024 | 928 | 450 (0%) | 0% | 1205.5 | 1,118,695 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 1204.71 per share. | 28 Aug 2024 | 2,237 | 1,378 (0%) | 0% | 1204.7 | 2,694,936 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 1206.30 per share. | 28 Aug 2024 | 200 | 0 (0%) | 0% | 1206.3 | 241,260 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 1205.44 per share. | 28 Aug 2024 | 766 | 200 (0%) | 0% | 1205.4 | 923,367 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 1204.79 per share. | 28 Aug 2024 | 228 | 966 (0%) | 0% | 1204.8 | 274,692 | Common Stock |
| Christine A. Poon | Director | Sale of securities on an exchange or to another person at price $ 1161.32 per share. | 15 Aug 2024 | 100 | 2,172 (0%) | 0% | 1161.3 | 116,132 | Common Stock |
| Christine A. Poon | Director | Sale of securities on an exchange or to another person at price $ 1160.45 per share. | 15 Aug 2024 | 234 | 2,272 (0%) | 0% | 1160.4 | 271,545 | Common Stock |
| Christine A. Poon | Director | Sale of securities on an exchange or to another person at price $ 1159.56 per share. | 15 Aug 2024 | 5,352 | 2,506 (0%) | 0% | 1159.6 | 6,205,965 | Common Stock |
| Christine A. Poon | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 413.33 per share. | 15 Aug 2024 | 10,838 | 13,010 (0%) | 0% | 413.3 | 4,479,671 | Common Stock |
| Christine A. Poon | Director | Sale of securities on an exchange or to another person at price $ 1156.30 per share. | 15 Aug 2024 | 2,368 | 9,630 (0%) | 0% | 1156.3 | 2,738,118 | Common Stock |
| Christine A. Poon | Director | Sale of securities on an exchange or to another person at price $ 1158.02 per share. | 15 Aug 2024 | 212 | 7,858 (0%) | 0% | 1158.0 | 245,500 | Common Stock |
| Christine A. Poon | Director | Sale of securities on an exchange or to another person at price $ 1155.72 per share. | 15 Aug 2024 | 1,012 | 11,998 (0%) | 0% | 1155.7 | 1,169,589 | Common Stock |
| Christine A. Poon | Director | Sale of securities on an exchange or to another person at price $ 1157.33 per share. | 15 Aug 2024 | 1,560 | 8,070 (0%) | 0% | 1157.3 | 1,805,435 | Common Stock |
| Christine A. Poon | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2024 | 10,838 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bonnie L. Bassler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 371.40 per share. | 15 Aug 2024 | 756 | 2,138 (0%) | 0% | 371.4 | 280,778 | Common Stock |
| Bonnie L. Bassler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2024 | 756 | 1,516 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bonnie L. Bassler | Director | Sale of securities on an exchange or to another person at price $ 1170.00 per share. | 15 Aug 2024 | 756 | 1,382 (0%) | 0% | 1170 | 884,520 | Common Stock |
| Neil Stahl | EVP Research and Development | Gift of securities by or to the insider at price $ 0.00 per share. | 13 Aug 2024 | 500 | 49,599 (0%) | 0% | 0 | Common Stock | |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1159.69 per share. | 13 Aug 2024 | 331 | 48,306 (0%) | 0% | 1159.7 | 383,857 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1158.78 per share. | 13 Aug 2024 | 189 | 48,637 (0%) | 0% | 1158.8 | 219,009 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1157.41 per share. | 13 Aug 2024 | 178 | 48,826 (0%) | 0% | 1157.4 | 206,019 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1156.43 per share. | 13 Aug 2024 | 1,016 | 49,004 (0%) | 0% | 1156.4 | 1,174,933 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1155.76 per share. | 13 Aug 2024 | 402 | 50,020 (0%) | 0% | 1155.8 | 464,616 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1154.66 per share. | 13 Aug 2024 | 777 | 50,422 (0%) | 0% | 1154.7 | 897,171 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1153.74 per share. | 13 Aug 2024 | 987 | 51,199 (0%) | 0% | 1153.7 | 1,138,741 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1151.46 per share. | 13 Aug 2024 | 185 | 52,383 (0%) | 0% | 1151.5 | 213,020 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1150.41 per share. | 13 Aug 2024 | 844 | 52,568 (0%) | 0% | 1150.4 | 970,946 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1149.60 per share. | 13 Aug 2024 | 294 | 53,412 (0%) | 0% | 1149.6 | 337,982 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1148.52 per share. | 13 Aug 2024 | 537 | 53,706 (0%) | 0% | 1148.5 | 616,755 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1146.61 per share. | 13 Aug 2024 | 51 | 54,243 (0%) | 0% | 1146.6 | 58,477 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1145.58 per share. | 13 Aug 2024 | 148 | 54,294 (0%) | 0% | 1145.6 | 169,546 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1144.89 per share. | 13 Aug 2024 | 45 | 54,442 (0%) | 0% | 1144.9 | 51,520 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1143.28 per share. | 13 Aug 2024 | 79 | 54,487 (0%) | 0% | 1143.3 | 90,319 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1142.94 per share. | 13 Aug 2024 | 48 | 54,566 (0%) | 0% | 1142.9 | 54,861 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1140.31 per share. | 13 Aug 2024 | 55 | 54,614 (0%) | 0% | 1140.3 | 62,717 | Common Stock |
| Andrew J Murphy | EVP Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1141.49 per share. | 13 Aug 2024 | 13,637 | 54,669 (0%) | 0% | 1141.5 | 15,566,499 | Common Stock |
| Andrew J Murphy | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 399.66 per share. | 13 Aug 2024 | 20,000 | 68,306 (0%) | 0% | 399.7 | 7,993,200 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 1152.36 per share. | 13 Aug 2024 | 197 | 52,186 (0%) | 0% | 1152.4 | 227,015 | Common Stock |
| Andrew J Murphy | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2024 | 20,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Neil Stahl | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 1081.83 per share. | 08 Aug 2024 | 100 | 56,096 (0%) | 0% | 1081.8 | 108,183 | Common Stock |
| Neil Stahl | EVP Research and Development | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Aug 2024 | 900 | 50,099 (0%) | 0% | 0 | Common Stock | |
| Neil Stahl | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 1086.15 per share. | 08 Aug 2024 | 300 | 50,999 (0%) | 0% | 1086.2 | 325,845 | Common Stock |
| Neil Stahl | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 1085.01 per share. | 08 Aug 2024 | 1,708 | 51,299 (0%) | 0% | 1085.0 | 1,853,197 | Common Stock |
| Neil Stahl | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 1084.61 per share. | 08 Aug 2024 | 1,883 | 53,007 (0%) | 0% | 1084.6 | 2,042,321 | Common Stock |
| Neil Stahl | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 1083.76 per share. | 08 Aug 2024 | 1,006 | 54,890 (0%) | 0% | 1083.8 | 1,090,263 | Common Stock |
| Neil Stahl | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 1082.69 per share. | 08 Aug 2024 | 200 | 55,896 (0%) | 0% | 1082.7 | 216,538 | Common Stock |
| Jason Pitofsky | VP Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2024 | 487 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Jason Pitofsky | VP Controller | Sale of securities on an exchange or to another person at price $ 1070.00 per share. | 07 Aug 2024 | 487 | 4,204 (0%) | 0% | 1070 | 521,090 | Common Stock |
| Jason Pitofsky | VP Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 372.46 per share. | 07 Aug 2024 | 487 | 4,691 (0%) | 0% | 372.5 | 181,388 | Common Stock |
| Bonnie L. Bassler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2024 | 756 | 2,272 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bonnie L. Bassler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 371.40 per share. | 02 Aug 2024 | 756 | 2,138 (0%) | 0% | 371.4 | 280,778 | Common Stock |
| Bonnie L. Bassler | Director | Sale of securities on an exchange or to another person at price $ 1115.00 per share. | 02 Aug 2024 | 756 | 1,382 (0%) | 0% | 1115 | 842,940 | Common Stock |
| Neil Stahl | EVP Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 555.67 per share. | 02 Aug 2024 | 23,638 | 74,637 (0%) | 0% | 555.7 | 13,134,927 | Common Stock |
| Neil Stahl | EVP Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2024 | 23,638 | 45,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Neil Stahl | EVP Research and Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1093.49 per share. | 02 Aug 2024 | 18,441 | 56,196 (0%) | 0% | 1093.5 | 20,165,049 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1059.00 per share. | 01 Aug 2024 | 1 | 17,880 (0%) | 0% | 1059 | 1,059 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1090.27 per share. | 01 Aug 2024 | 11 | 17,824 (0%) | 0% | 1090.3 | 11,993 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1089.57 per share. | 01 Aug 2024 | 7 | 17,835 (0%) | 0% | 1089.6 | 7,627 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1088.67 per share. | 01 Aug 2024 | 3 | 17,842 (0%) | 0% | 1088.7 | 3,266 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1095.33 per share. | 01 Aug 2024 | 3 | 17,793 (0%) | 0% | 1095.3 | 3,286 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1096.33 per share. | 01 Aug 2024 | 3 | 17,790 (0%) | 0% | 1096.3 | 3,289 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1097.67 per share. | 01 Aug 2024 | 3 | 17,787 (0%) | 0% | 1097.7 | 3,293 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1098.00 per share. | 01 Aug 2024 | 1 | 17,786 (0%) | 0% | 1098 | 1,098 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1099.67 per share. | 01 Aug 2024 | 3 | 17,783 (0%) | 0% | 1099.7 | 3,299 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1100.00 per share. | 01 Aug 2024 | 1 | 17,782 (0%) | 0% | 1100 | 1,100 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1093.43 per share. | 01 Aug 2024 | 7 | 17,797 (0%) | 0% | 1093.4 | 7,654 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1053.00 per share. | 01 Aug 2024 | 1 | 17,881 (0%) | 0% | 1053 | 1,053 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1092.57 per share. | 01 Aug 2024 | 7 | 17,804 (0%) | 0% | 1092.6 | 7,648 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1091.46 per share. | 01 Aug 2024 | 13 | 17,811 (0%) | 0% | 1091.5 | 14,189 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1094.00 per share. | 01 Aug 2024 | 1 | 17,796 (0%) | 0% | 1094 | 1,094 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1087.50 per share. | 01 Aug 2024 | 2 | 17,845 (0%) | 0% | 1087.5 | 2,175 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1086.50 per share. | 01 Aug 2024 | 2 | 17,847 (0%) | 0% | 1086.5 | 2,173 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1085.67 per share. | 01 Aug 2024 | 3 | 17,849 (0%) | 0% | 1085.7 | 3,257 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1084.67 per share. | 01 Aug 2024 | 3 | 17,852 (0%) | 0% | 1084.7 | 3,254 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1084.00 per share. | 01 Aug 2024 | 1 | 17,855 (0%) | 0% | 1084 | 1,084 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1082.00 per share. | 01 Aug 2024 | 1 | 17,856 (0%) | 0% | 1082 | 1,082 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1080.00 per share. | 01 Aug 2024 | 1 | 17,857 (0%) | 0% | 1080 | 1,080 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1076.00 per share. | 01 Aug 2024 | 3 | 17,858 (0%) | 0% | 1076 | 3,228 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1074.00 per share. | 01 Aug 2024 | 1 | 17,861 (0%) | 0% | 1074 | 1,074 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1073.00 per share. | 01 Aug 2024 | 1 | 17,862 (0%) | 0% | 1073 | 1,073 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1070.50 per share. | 01 Aug 2024 | 4 | 17,863 (0%) | 0% | 1070.5 | 4,282 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1068.00 per share. | 01 Aug 2024 | 1 | 17,867 (0%) | 0% | 1068 | 1,068 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1066.25 per share. | 01 Aug 2024 | 4 | 17,869 (0%) | 0% | 1066.3 | 4,265 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1068.00 per share. | 01 Aug 2024 | 1 | 17,868 (0%) | 0% | 1068 | 1,068 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1065.33 per share. | 01 Aug 2024 | 6 | 17,873 (0%) | 0% | 1065.3 | 6,392 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1063.00 per share. | 01 Aug 2024 | 1 | 17,879 (0%) | 0% | 1063 | 1,063 | Common Stock |
| Marion McCourt | EVP Commercial | Sale of securities on an exchange or to another person at price $ 1060.86 per share. | 01 Aug 2024 | 1,137 | 12,931 (0%) | 0% | 1060.9 | 1,206,198 | Common Stock |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 372.46 per share. | 01 Aug 2024 | 1,137 | 14,068 (0%) | 0% | 372.5 | 423,487 | Common Stock |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 1,137 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph J. Larosa | EVP General Counsel and Secret | Sale of securities on an exchange or to another person at price $ 1088.95 per share. | 11 Jul 2024 | 1,866 | 37,937 (0%) | 0% | 1089.0 | 2,031,981 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1047.00 per share. | 01 Jul 2024 | 3 | 17,979 (0%) | 0% | 1047 | 3,141 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1054.00 per share. | 01 Jul 2024 | 1 | 17,955 (0%) | 0% | 1054 | 1,054 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1057.00 per share. | 01 Jul 2024 | 2 | 17,953 (0%) | 0% | 1057 | 2,114 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1057.50 per share. | 01 Jul 2024 | 2 | 17,951 (0%) | 0% | 1057.5 | 2,115 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1058.47 per share. | 01 Jul 2024 | 17 | 17,934 (0%) | 0% | 1058.5 | 17,994 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1059.33 per share. | 01 Jul 2024 | 3 | 17,931 (0%) | 0% | 1059.3 | 3,178 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1060.00 per share. | 01 Jul 2024 | 3 | 17,928 (0%) | 0% | 1060 | 3,180 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1061.67 per share. | 01 Jul 2024 | 3 | 17,925 (0%) | 0% | 1061.7 | 3,185 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1062.32 per share. | 01 Jul 2024 | 19 | 17,906 (0%) | 0% | 1062.3 | 20,184 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1063.80 per share. | 01 Jul 2024 | 5 | 17,901 (0%) | 0% | 1063.8 | 5,319 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1064.57 per share. | 01 Jul 2024 | 7 | 17,894 (0%) | 0% | 1064.6 | 7,452 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1065.67 per share. | 01 Jul 2024 | 3 | 17,891 (0%) | 0% | 1065.7 | 3,197 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1066.50 per share. | 01 Jul 2024 | 4 | 17,887 (0%) | 0% | 1066.5 | 4,266 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1067.67 per share. | 01 Jul 2024 | 3 | 17,884 (0%) | 0% | 1067.7 | 3,203 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1068.00 per share. | 01 Jul 2024 | 2 | 17,882 (0%) | 0% | 1068 | 2,136 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1053.62 per share. | 01 Jul 2024 | 8 | 17,956 (0%) | 0% | 1053.6 | 8,429 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1052.17 per share. | 01 Jul 2024 | 6 | 17,964 (0%) | 0% | 1052.2 | 6,313 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1051.57 per share. | 01 Jul 2024 | 7 | 17,970 (0%) | 0% | 1051.6 | 7,361 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1051.00 per share. | 01 Jul 2024 | 2 | 17,977 (0%) | 0% | 1051 | 2,102 | Common Stock |
| Marion McCourt | EVP Commercial | Sale of securities on an exchange or to another person at price $ 1047.11 per share. | 01 Jul 2024 | 1,137 | 12,931 (0%) | 0% | 1047.1 | 1,190,564 | Common Stock |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 1,137 | 1,137 | - | - | Non-Qualified Stock Option (right to buy) | |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 372.46 per share. | 01 Jul 2024 | 1,137 | 14,068 (0%) | 0% | 372.5 | 423,487 | Common Stock |
| Joseph J. Larosa | EVP General Counsel and Secret | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1060.13 per share. | 24 Jun 2024 | 11,084 | 39,803 (0%) | 0% | 1060.1 | 11,750,481 | Common Stock |
| Joseph J. Larosa | EVP General Counsel and Secret | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 14,450 | 14,450 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph J. Larosa | EVP General Counsel and Secret | Exercise or conversion of derivative security received from the company (such as an option) at price $ 555.67 per share. | 24 Jun 2024 | 14,450 | 50,887 (0%) | 0% | 555.7 | 8,029,432 | Common Stock |
| Bonnie L. Bassler | Director | Sale of securities on an exchange or to another person at price $ 1062.00 per share. | 24 Jun 2024 | 756 | 1,382 (0%) | 0% | 1062 | 802,872 | Common Stock |
| Bonnie L. Bassler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 756 | 3,028 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bonnie L. Bassler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 371.40 per share. | 24 Jun 2024 | 756 | 2,138 (0%) | 0% | 371.4 | 280,778 | Common Stock |
| Michael S. Brown | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2024 | 1,535 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael S. Brown | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 625.60 per share. | 14 Jun 2024 | 1,535 | 2,917 (0%) | 0% | 625.6 | 960,296 | Common Stock |
| Michael S. Brown | Director | Sale of securities on an exchange or to another person at price $ 1040.00 per share. | 14 Jun 2024 | 1,535 | 1,382 (0%) | 0% | 1040 | 1,596,400 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 1015.30 per share. | 11 Jun 2024 | 14,879 | 40,255 (0%) | 0% | 1015.3 | 15,106,649 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 1016.62 per share. | 11 Jun 2024 | 270 | 39,985 (0%) | 0% | 1016.6 | 274,487 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | 11 Jun 2024 | 1,000 | 1,000 (0%) | 0% | 0 | Common Stock | ||
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 1025.27 per share. | 11 Jun 2024 | 1,000 | 0 (0%) | 0% | 1025.3 | 1,025,270 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | 11 Jun 2024 | 1,000 | 14,775 | - | - | Class A Stock | ||
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 1016.04 per share. | 11 Jun 2024 | 1,743 | 55,134 (0%) | 0% | 1016.0 | 1,770,958 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 1015.28 per share. | 11 Jun 2024 | 7,321 | 56,877 (0%) | 0% | 1015.3 | 7,432,865 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Jun 2024 | 75,799 | 0 (0%) | 0% | 0 | Common Stock | |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Jun 2024 | 37,900 | 56,048 (0%) | 0% | 0 | Common Stock | |
| Joseph J. Larosa | EVP General Counsel and Secret | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Jun 2024 | 1,608 | 0 (0%) | 0% | 0 | Common Stock | |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 1015.02 per share. | 06 Jun 2024 | 787 | 64,198 (0%) | 0% | 1015.0 | 798,821 | Common Stock |
| Bonnie L. Bassler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2024 | 827 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bonnie L. Bassler | Director | Sale of securities on an exchange or to another person at price $ 1011.00 per share. | 05 Jun 2024 | 827 | 1,382 (0%) | 0% | 1011 | 836,097 | Common Stock |
| Bonnie L. Bassler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 380.95 per share. | 05 Jun 2024 | 827 | 2,209 (0%) | 0% | 381.0 | 315,046 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 979.50 per share. | 03 Jun 2024 | 2 | 18,080 (0%) | 0% | 979.5 | 1,959 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 1000.00 per share. | 03 Jun 2024 | 5 | 17,982 (0%) | 0% | 1000 | 5,000 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 999.43 per share. | 03 Jun 2024 | 7 | 17,987 (0%) | 0% | 999.4 | 6,996 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 998.43 per share. | 03 Jun 2024 | 14 | 17,994 (0%) | 0% | 998.4 | 13,978 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 997.73 per share. | 03 Jun 2024 | 15 | 18,008 (0%) | 0% | 997.7 | 14,966 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 996.83 per share. | 03 Jun 2024 | 12 | 18,023 (0%) | 0% | 996.8 | 11,962 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 995.83 per share. | 03 Jun 2024 | 6 | 18,035 (0%) | 0% | 995.8 | 5,975 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 994.20 per share. | 03 Jun 2024 | 5 | 18,041 (0%) | 0% | 994.2 | 4,971 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 993.17 per share. | 03 Jun 2024 | 12 | 18,046 (0%) | 0% | 993.2 | 11,918 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 992.14 per share. | 03 Jun 2024 | 7 | 18,058 (0%) | 0% | 992.1 | 6,945 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 990.75 per share. | 03 Jun 2024 | 4 | 18,065 (0%) | 0% | 990.8 | 3,963 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 988.50 per share. | 03 Jun 2024 | 2 | 18,069 (0%) | 0% | 988.5 | 1,977 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 984.50 per share. | 03 Jun 2024 | 2 | 18,071 (0%) | 0% | 984.5 | 1,969 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 983.00 per share. | 03 Jun 2024 | 1 | 18,073 (0%) | 0% | 983 | 983 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 982.00 per share. | 03 Jun 2024 | 3 | 18,074 (0%) | 0% | 982 | 2,946 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 980.00 per share. | 03 Jun 2024 | 3 | 18,077 (0%) | 0% | 980 | 2,940 | Common Stock |
| Marion McCourt | EVP Commercial | Sale of securities on an exchange or to another person at price $ 980.16 per share. | 03 Jun 2024 | 1,138 | 12,931 (0%) | 0% | 980.2 | 1,115,422 | Common Stock |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 1,138 | 2,274 | - | - | Non-Qualified Stock Option (right to buy) | |
| Marion McCourt | EVP Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 372.46 per share. | 03 Jun 2024 | 1,138 | 14,069 (0%) | 0% | 372.5 | 423,859 | Common Stock |
| Michael S. Brown | Director | Sale of securities on an exchange or to another person at price $ 974.86 per share. | 28 May 2024 | 1,172 | 1,382 (0%) | 0% | 974.9 | 1,142,536 | Common Stock |
| Michael S. Brown | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 625.60 per share. | 28 May 2024 | 1,172 | 2,554 (0%) | 0% | 625.6 | 733,203 | Common Stock |
| Michael S. Brown | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 1,172 | 1,535 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph J. Larosa | EVP General Counsel and Secret | Sale of securities on an exchange or to another person at price $ 994.90 per share. | 21 May 2024 | 1,865 | 34,678 (0%) | 0% | 994.9 | 1,855,489 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 980.07 per share. | 17 May 2024 | 143 | 466,877 (0%) | 0% | 980.1 | 140,150 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 979.22 per share. | 17 May 2024 | 22,687 | 467,020 (0%) | 0% | 979.2 | 22,215,564 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 973.80 per share. | 16 May 2024 | 2,653 | 809,728 (0%) | 0% | 973.8 | 2,583,491 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 972.22 per share. | 16 May 2024 | 790 | 812,381 (0%) | 0% | 972.2 | 768,054 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 971.56 per share. | 16 May 2024 | 4,922 | 813,171 (0%) | 0% | 971.6 | 4,782,018 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 970.26 per share. | 16 May 2024 | 4,669 | 818,093 (0%) | 0% | 970.3 | 4,530,144 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 969.39 per share. | 16 May 2024 | 9,501 | 822,762 (0%) | 0% | 969.4 | 9,210,174 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 968.44 per share. | 16 May 2024 | 3,213 | 832,263 (0%) | 0% | 968.4 | 3,111,598 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 967.40 per share. | 16 May 2024 | 907 | 835,476 (0%) | 0% | 967.4 | 877,432 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 978.18 per share. | 16 May 2024 | 379 | 786,383 (0%) | 0% | 978.2 | 370,730 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 977.38 per share. | 16 May 2024 | 1,227 | 786,762 (0%) | 0% | 977.4 | 1,199,245 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 976.52 per share. | 16 May 2024 | 4,886 | 787,989 (0%) | 0% | 976.5 | 4,771,277 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 975.48 per share. | 16 May 2024 | 9,242 | 792,875 (0%) | 0% | 975.5 | 9,015,386 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 974.51 per share. | 16 May 2024 | 7,611 | 802,117 (0%) | 0% | 974.5 | 7,416,996 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 978.44 per share. | 15 May 2024 | 4,865 | 843,240 (0%) | 0% | 978.4 | 4,760,111 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 977.42 per share. | 15 May 2024 | 9,851 | 848,105 (0%) | 0% | 977.4 | 9,628,564 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 976.56 per share. | 15 May 2024 | 6,885 | 857,956 (0%) | 0% | 976.6 | 6,723,616 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 975.60 per share. | 15 May 2024 | 5,225 | 864,841 (0%) | 0% | 975.6 | 5,097,510 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 974.47 per share. | 15 May 2024 | 4,778 | 870,066 (0%) | 0% | 974.5 | 4,656,018 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 973.43 per share. | 15 May 2024 | 1,865 | 874,844 (0%) | 0% | 973.4 | 1,815,447 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 972.50 per share. | 15 May 2024 | 784 | 876,709 (0%) | 0% | 972.5 | 762,440 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 971.28 per share. | 15 May 2024 | 406 | 877,493 (0%) | 0% | 971.3 | 394,340 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 970.36 per share. | 15 May 2024 | 846 | 877,899 (0%) | 0% | 970.4 | 820,925 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 969.14 per share. | 15 May 2024 | 1,930 | 878,745 (0%) | 0% | 969.1 | 1,870,440 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 968.43 per share. | 15 May 2024 | 3,387 | 880,675 (0%) | 0% | 968.4 | 3,280,072 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 989.14 per share. | 15 May 2024 | 120 | 836,383 (0%) | 0% | 989.1 | 118,697 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 988.36 per share. | 15 May 2024 | 373 | 836,503 (0%) | 0% | 988.4 | 368,658 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 987.38 per share. | 15 May 2024 | 182 | 836,876 (0%) | 0% | 987.4 | 179,703 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 986.40 per share. | 15 May 2024 | 442 | 837,058 (0%) | 0% | 986.4 | 435,989 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 985.62 per share. | 15 May 2024 | 647 | 837,500 (0%) | 0% | 985.6 | 637,696 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 984.02 per share. | 15 May 2024 | 53 | 838,147 (0%) | 0% | 984.0 | 52,153 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 983.88 per share. | 15 May 2024 | 727 | 838,200 (0%) | 0% | 983.9 | 715,281 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 982.29 per share. | 15 May 2024 | 303 | 838,927 (0%) | 0% | 982.3 | 297,634 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 981.52 per share. | 15 May 2024 | 2,283 | 839,230 (0%) | 0% | 981.5 | 2,240,810 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 980.72 per share. | 15 May 2024 | 1,223 | 841,513 (0%) | 0% | 980.7 | 1,199,421 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 979.87 per share. | 15 May 2024 | 504 | 842,736 (0%) | 0% | 979.9 | 493,854 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 967.45 per share. | 15 May 2024 | 1,428 | 884,062 (0%) | 0% | 967.5 | 1,381,519 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 966.29 per share. | 15 May 2024 | 782 | 885,490 (0%) | 0% | 966.3 | 755,639 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Sale of securities on an exchange or to another person at price $ 965.69 per share. | 15 May 2024 | 111 | 886,272 (0%) | 0% | 965.7 | 107,192 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 399.66 per share. | 13 May 2024 | 203,204 | 577,633 (0%) | 0% | 399.7 | 81,212,511 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 May 2024 | 203,204 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 988.76 per share. | 13 May 2024 | 299 | 397,259 (0%) | 0% | 988.8 | 295,639 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 987.46 per share. | 13 May 2024 | 228 | 397,558 (0%) | 0% | 987.5 | 225,141 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 986.57 per share. | 13 May 2024 | 103 | 397,786 (0%) | 0% | 986.6 | 101,617 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 985.72 per share. | 13 May 2024 | 281 | 397,889 (0%) | 0% | 985.7 | 276,987 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 984.00 per share. | 13 May 2024 | 305 | 398,170 (0%) | 0% | 984 | 300,120 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 983.91 per share. | 13 May 2024 | 250 | 398,475 (0%) | 0% | 983.9 | 245,978 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 982.66 per share. | 13 May 2024 | 235 | 398,725 (0%) | 0% | 982.7 | 230,925 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 981.50 per share. | 13 May 2024 | 1,081 | 398,960 (0%) | 0% | 981.5 | 1,061,002 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 980.64 per share. | 13 May 2024 | 295 | 400,041 (0%) | 0% | 980.6 | 289,289 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 979.05 per share. | 13 May 2024 | 7,864 | 400,336 (0%) | 0% | 979.0 | 7,699,249 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 980.10 per share. | 13 May 2024 | 2,302 | 408,200 (0%) | 0% | 980.1 | 2,256,190 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Sale of securities on an exchange or to another person at price $ 979.16 per share. | 13 May 2024 | 22,698 | 410,502 (0%) | 0% | 979.2 | 22,224,974 | Common Stock |
| Leonard S. Schleifer | Director, Bd. Co-Chair, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 976.79 per share. | 13 May 2024 | 144,433 | 433,200 (0%) | 0% | 976.8 | 141,080,710 | Common Stock |
| George L. Sing | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 942.53 per share. | 03 May 2024 | 877 | 27,472 (0%) | 0% | 942.5 | 826,599 | Common Stock |
| George L. Sing | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 413.33 per share. | 03 May 2024 | 2,000 | 28,349 (0%) | 0% | 413.3 | 826,660 | Common Stock |
| George L. Sing | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2024 | 2,000 | 3,338 | - | - | Non-Qualified Stock Option (right to buy) | |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 889.67 per share. | 01 May 2024 | 3 | 18,179 (0%) | 0% | 889.7 | 2,669 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 913.00 per share. | 01 May 2024 | 1 | 18,082 (0%) | 0% | 913 | 913 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 912.00 per share. | 01 May 2024 | 1 | 18,083 (0%) | 0% | 912 | 912 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 911.50 per share. | 01 May 2024 | 4 | 18,084 (0%) | 0% | 911.5 | 3,646 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 910.50 per share. | 01 May 2024 | 6 | 18,088 (0%) | 0% | 910.5 | 5,463 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 909.50 per share. | 01 May 2024 | 4 | 18,094 (0%) | 0% | 909.5 | 3,638 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 907.50 per share. | 01 May 2024 | 2 | 18,098 (0%) | 0% | 907.5 | 1,815 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 906.25 per share. | 01 May 2024 | 4 | 18,100 (0%) | 0% | 906.3 | 3,625 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 905.50 per share. | 01 May 2024 | 2 | 18,104 (0%) | 0% | 905.5 | 1,811 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 905.00 per share. | 01 May 2024 | 1 | 18,106 (0%) | 0% | 905 | 905 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 903.00 per share. | 01 May 2024 | 1 | 18,107 (0%) | 0% | 903 | 903 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 903.00 per share. | 01 May 2024 | 1 | 18,108 (0%) | 0% | 903 | 903 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 901.50 per share. | 01 May 2024 | 4 | 18,109 (0%) | 0% | 901.5 | 3,606 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 900.40 per share. | 01 May 2024 | 5 | 18,113 (0%) | 0% | 900.4 | 4,502 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 899.43 per share. | 01 May 2024 | 7 | 18,118 (0%) | 0% | 899.4 | 6,296 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 898.53 per share. | 01 May 2024 | 17 | 18,125 (0%) | 0% | 898.5 | 15,275 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 897.67 per share. | 01 May 2024 | 9 | 18,142 (0%) | 0% | 897.7 | 8,079 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 896.67 per share. | 01 May 2024 | 3 | 18,151 (0%) | 0% | 896.7 | 2,690 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 895.50 per share. | 01 May 2024 | 2 | 18,154 (0%) | 0% | 895.5 | 1,791 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 893.20 per share. | 01 May 2024 | 5 | 18,156 (0%) | 0% | 893.2 | 4,466 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 892.56 per share. | 01 May 2024 | 9 | 18,161 (0%) | 0% | 892.6 | 8,033 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 891.57 per share. | 01 May 2024 | 7 | 18,170 (0%) | 0% | 891.6 | 6,241 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 891.00 per share. | 01 May 2024 | 2 | 18,177 (0%) | 0% | 891 | 1,782 | Common Stock |
| Marion McCourt | EVP Commercial | Sale of securities on an exchange or to another person at price $ 889.41 per share. | 01 May 2024 | 250 | 12,931 (0%) | 0% | 889.4 | 222,353 | Common Stock |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Gift of securities by or to the insider at price $ 0.00 per share. | 29 Apr 2024 | 18,148 | 18,148 (0%) | 0% | 0 | Common Stock | |
| George D. Yancopoulos | Director, Bd. Co-Chair, President & CSO | Gift of securities by or to the insider at price $ 0.00 per share. | 29 Apr 2024 | 36,296 | 0 (0%) | 0% | 0 | Common Stock | |
| Marion McCourt | EVP Commercial | Sale of securities on an exchange or to another person at price $ 964.73 per share. | 01 Apr 2024 | 250 | 13,181 (0%) | 0% | 964.7 | 241,183 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 960.53 per share. | 01 Apr 2024 | 15 | 18,254 (0%) | 0% | 960.5 | 14,408 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 959.00 per share. | 01 Apr 2024 | 2 | 18,278 (0%) | 0% | 959 | 1,918 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 958.00 per share. | 01 Apr 2024 | 2 | 18,280 (0%) | 0% | 958 | 1,916 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 961.57 per share. | 01 Apr 2024 | 14 | 18,240 (0%) | 0% | 961.6 | 13,462 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 959.44 per share. | 01 Apr 2024 | 9 | 18,269 (0%) | 0% | 959.4 | 8,635 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 965.38 per share. | 01 Apr 2024 | 13 | 18,182 (0%) | 0% | 965.4 | 12,550 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 964.44 per share. | 01 Apr 2024 | 16 | 18,195 (0%) | 0% | 964.4 | 15,431 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 963.60 per share. | 01 Apr 2024 | 20 | 18,211 (0%) | 0% | 963.6 | 19,272 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 962.44 per share. | 01 Apr 2024 | 9 | 18,231 (0%) | 0% | 962.4 | 8,662 | Common Stock |
| Andrew J Murphy | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 399.66 per share. | 13 Mar 2024 | 20,000 | 68,306 (0%) | 0% | 399.7 | 7,993,200 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 968.20 per share. | 13 Mar 2024 | 196 | 48,306 (0%) | 0% | 968.2 | 189,767 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 966.29 per share. | 13 Mar 2024 | 17 | 48,502 (0%) | 0% | 966.3 | 16,427 | Common Stock |
| Andrew J Murphy | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2024 | 20,000 | 20,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 965.51 per share. | 13 Mar 2024 | 78 | 48,519 (0%) | 0% | 965.5 | 75,310 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 963.00 per share. | 13 Mar 2024 | 1 | 48,597 (0%) | 0% | 963 | 963 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 961.74 per share. | 13 Mar 2024 | 47 | 48,598 (0%) | 0% | 961.7 | 45,202 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 959.36 per share. | 13 Mar 2024 | 512 | 48,645 (0%) | 0% | 959.4 | 491,192 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 958.34 per share. | 13 Mar 2024 | 477 | 49,157 (0%) | 0% | 958.3 | 457,128 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 957.35 per share. | 13 Mar 2024 | 730 | 49,634 (0%) | 0% | 957.4 | 698,866 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 956.34 per share. | 13 Mar 2024 | 1,108 | 50,364 (0%) | 0% | 956.3 | 1,059,625 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 955.54 per share. | 13 Mar 2024 | 545 | 51,472 (0%) | 0% | 955.5 | 520,769 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 954.66 per share. | 13 Mar 2024 | 870 | 52,017 (0%) | 0% | 954.7 | 830,554 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 953.77 per share. | 13 Mar 2024 | 576 | 52,887 (0%) | 0% | 953.8 | 549,372 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 952.40 per share. | 13 Mar 2024 | 444 | 53,463 (0%) | 0% | 952.4 | 422,866 | Common Stock |
| Andrew J Murphy | EVP Research | Sale of securities on an exchange or to another person at price $ 951.92 per share. | 13 Mar 2024 | 182 | 53,907 (0%) | 0% | 951.9 | 173,249 | Common Stock |
| Andrew J Murphy | EVP Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 971.82 per share. | 13 Mar 2024 | 14,217 | 54,089 (0%) | 0% | 971.8 | 13,816,365 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 983.58 per share. | 01 Mar 2024 | 12 | 18,324 (0%) | 0% | 983.6 | 11,803 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 984.47 per share. | 01 Mar 2024 | 19 | 18,305 (0%) | 0% | 984.5 | 18,705 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 985.80 per share. | 01 Mar 2024 | 10 | 18,295 (0%) | 0% | 985.8 | 9,858 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 986.62 per share. | 01 Mar 2024 | 8 | 18,287 (0%) | 0% | 986.6 | 7,893 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 987.25 per share. | 01 Mar 2024 | 4 | 18,283 (0%) | 0% | 987.3 | 3,949 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 988.00 per share. | 01 Mar 2024 | 1 | 18,282 (0%) | 0% | 988 | 988 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 969.00 per share. | 01 Mar 2024 | 1 | 18,379 (0%) | 0% | 969 | 969 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 968.00 per share. | 01 Mar 2024 | 1 | 18,381 (0%) | 0% | 968 | 968 | Common Stock |
| Marion McCourt | EVP Commercial | Sale of securities on an exchange or to another person at price $ 967.50 per share. | 01 Mar 2024 | 358 | 13,431 (0%) | 0% | 967.5 | 346,365 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 969.00 per share. | 01 Mar 2024 | 1 | 18,380 (0%) | 0% | 969 | 969 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 970.50 per share. | 01 Mar 2024 | 4 | 18,375 (0%) | 0% | 970.5 | 3,882 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 972.00 per share. | 01 Mar 2024 | 1 | 18,374 (0%) | 0% | 972 | 972 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 972.50 per share. | 01 Mar 2024 | 2 | 18,372 (0%) | 0% | 972.5 | 1,945 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 975.00 per share. | 01 Mar 2024 | 1 | 18,371 (0%) | 0% | 975 | 975 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 975.50 per share. | 01 Mar 2024 | 2 | 18,369 (0%) | 0% | 975.5 | 1,951 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 977.00 per share. | 01 Mar 2024 | 2 | 18,367 (0%) | 0% | 977 | 1,954 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 977.50 per share. | 01 Mar 2024 | 2 | 18,365 (0%) | 0% | 977.5 | 1,955 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 978.00 per share. | 01 Mar 2024 | 1 | 18,364 (0%) | 0% | 978 | 978 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 980.00 per share. | 01 Mar 2024 | 1 | 18,363 (0%) | 0% | 980 | 980 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 980.00 per share. | 01 Mar 2024 | 1 | 18,362 (0%) | 0% | 980 | 980 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 981.67 per share. | 01 Mar 2024 | 15 | 18,347 (0%) | 0% | 981.7 | 14,725 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 982.64 per share. | 01 Mar 2024 | 11 | 18,336 (0%) | 0% | 982.6 | 10,809 | Common Stock |
| L. George Sing | Director | Sale of securities on an exchange or to another person at price $ 995.00 per share. | 26 Feb 2024 | 500 | 26,349 (0%) | 0% | 995 | 497,500 | Common Stock |
| J. Larosa Joseph | EVP General Counsel and Secret | Sale of securities on an exchange or to another person at price $ 990.00 per share. | 26 Feb 2024 | 1,000 | 36,543 (0%) | 0% | 990 | 990,000 | Common Stock |
| George Sing L. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 413.33 per share. | 26 Feb 2024 | 500 | 26,849 (0%) | 0% | 413.3 | 206,665 | Common Stock |
| George L. Sing | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 413.33 per share. | 26 Feb 2024 | 500 | 26,849 (0%) | 0% | 413.3 | 206,665 | Common Stock |
| L. Sing George | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2024 | 1,000 | 5,338 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bassler L. Bonnie | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 391.92 per share. | 26 Feb 2024 | 854 | 2,236 (0%) | 0% | 391.9 | 334,700 | Common Stock |
| L. Bassler Bonnie | Director | Sale of securities on an exchange or to another person at price $ 979.25 per share. | 26 Feb 2024 | 854 | 1,382 (0%) | 0% | 979.3 | 836,280 | Common Stock |
| Sing L. George | Director | Sale of securities on an exchange or to another person at price $ 990.00 per share. | 26 Feb 2024 | 500 | 26,349 (0%) | 0% | 990 | 495,000 | Common Stock |
| L. Bassler Bonnie | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2024 | 854 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Neil Stahl | EVP Research and Development | Gift of securities by or to the insider at price $ 0.00 per share. | 26 Feb 2024 | 1,020 | 50,999 (0%) | 0% | 0 | Common Stock | |
| George L. Sing | Director | Sale of securities on an exchange or to another person at price $ 970.00 per share. | 22 Feb 2024 | 1,000 | 26,349 (0%) | 0% | 970 | 970,000 | Common Stock |
| George L. Sing | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2024 | 3,000 | 6,838 | - | - | Non-Qualified Stock Option (right to buy) | |
| L. George Sing | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 413.33 per share. | 22 Feb 2024 | 500 | 26,849 (0%) | 0% | 413.3 | 206,665 | Common Stock |
| George L. Sing | Director | Sale of securities on an exchange or to another person at price $ 965.00 per share. | 22 Feb 2024 | 1,000 | 26,349 (0%) | 0% | 965 | 965,000 | Common Stock |
| George Sing L. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2024 | 500 | 6,338 | - | - | Non-Qualified Stock Option (right to buy) | |
| Sing L. George | Director | Sale of securities on an exchange or to another person at price $ 960.00 per share. | 22 Feb 2024 | 1,000 | 26,349 (0%) | 0% | 960 | 960,000 | Common Stock |
| L. George Sing | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 413.33 per share. | 22 Feb 2024 | 1,000 | 27,349 (0%) | 0% | 413.3 | 413,330 | Common Stock |
| Sing L. George | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 413.33 per share. | 22 Feb 2024 | 1,000 | 27,349 (0%) | 0% | 413.3 | 413,330 | Common Stock |
| Sing L. George | Director | Sale of securities on an exchange or to another person at price $ 985.00 per share. | 22 Feb 2024 | 500 | 26,349 (0%) | 0% | 985 | 492,500 | Common Stock |
| Larosa J. Joseph | EVP General Counsel and Secret | Sale of securities on an exchange or to another person at price $ 967.65 per share. | 22 Feb 2024 | 1,000 | 37,543 (0%) | 0% | 967.7 | 967,650 | Common Stock |
| George Sing L. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 413.33 per share. | 22 Feb 2024 | 1,000 | 27,349 (0%) | 0% | 413.3 | 413,330 | Common Stock |
| George Yancopoulos D. | Director, Bd. Co-Chair, President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Feb 2024 | 172,723 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| D. Yancopoulos George | Director, Bd. Co-Chair, President & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 953.83 per share. | 15 Feb 2024 | 123,601 | 801,608 (0%) | 0% | 953.8 | 117,894,342 | Common Stock |
| Yancopoulos George D. | Director, Bd. Co-Chair, President & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 399.66 per share. | 15 Feb 2024 | 172,723 | 925,209 (0%) | 0% | 399.7 | 69,030,474 | Common Stock |
| Van Plew P. Daniel | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 947.81 per share. | 14 Feb 2024 | 240 | 21,215 (0%) | 0% | 947.8 | 227,474 | Common Stock |
| P. Daniel Van Plew | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 940.44 per share. | 14 Feb 2024 | 4,261 | 25,136 (0%) | 0% | 940.4 | 4,007,215 | Common Stock |
| P. Van Plew Daniel | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 949.07 per share. | 14 Feb 2024 | 112 | 20,953 (0%) | 0% | 949.1 | 106,296 | Common Stock |
| P. Daniel Van Plew | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 950.45 per share. | 14 Feb 2024 | 375 | 20,578 (0%) | 0% | 950.5 | 356,419 | Common Stock |
| Daniel P. Van Plew | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 945.81 per share. | 14 Feb 2024 | 95 | 21,455 (0%) | 0% | 945.8 | 89,852 | Common Stock |
| P. Daniel Van Plew | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 939.60 per share. | 14 Feb 2024 | 750 | 29,397 (0%) | 0% | 939.6 | 704,700 | Common Stock |
| Daniel Van Plew P. | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 938.13 per share. | 14 Feb 2024 | 226 | 30,147 (0%) | 0% | 938.1 | 212,017 | Common Stock |
| Daniel P. Van Plew | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 941.41 per share. | 14 Feb 2024 | 275 | 24,861 (0%) | 0% | 941.4 | 258,888 | Common Stock |
| Daniel Van Plew P. | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 944.30 per share. | 14 Feb 2024 | 620 | 21,550 (0%) | 0% | 944.3 | 585,466 | Common Stock |
| Van Plew Daniel P. | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 948.70 per share. | 14 Feb 2024 | 150 | 21,065 (0%) | 0% | 948.7 | 142,305 | Common Stock |
| Daniel P. Van Plew | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 951.77 per share. | 14 Feb 2024 | 200 | 20,378 (0%) | 0% | 951.8 | 190,354 | Common Stock |
| Van Plew P. Daniel | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 943.51 per share. | 14 Feb 2024 | 2,691 | 22,170 (0%) | 0% | 943.5 | 2,538,985 | Common Stock |
| P. Daniel Van Plew | EVP & General Mgr, Industrial | Sale of securities on an exchange or to another person at price $ 937.94 per share. | 14 Feb 2024 | 439 | 30,373 (0%) | 0% | 937.9 | 411,756 | Common Stock |
| Daniel P. Van Plew | EVP & General Mgr, Industrial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 951.68 per share. | 09 Feb 2024 | 8,600 | 24,028 (0%) | 0% | 951.7 | 8,184,448 | Common Stock |
| R. Christopher Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 953.47 per share. | 09 Feb 2024 | 1,342 | 16,072 (0%) | 0% | 953.5 | 1,279,557 | Common Stock |
| Van Plew Daniel P. | EVP & General Mgr, Industrial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 372.46 per share. | 09 Feb 2024 | 12,250 | 32,628 (0%) | 0% | 372.5 | 4,562,635 | Common Stock |
| Daniel P. Van Plew | EVP & General Mgr, Industrial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2024 | 12,250 | 12,250 | - | - | Non-Qualified Stock Option (right to buy) | |
| Fenimore Christopher R. | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 955.00 per share. | 09 Feb 2024 | 600 | 14,372 (0%) | 0% | 955 | 573,000 | Common Stock |
| Daniel P. Van Plew | EVP & General Mgr, Industrial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 951.68 per share. | 09 Feb 2024 | 16,341 | 30,812 (0%) | 0% | 951.7 | 15,551,403 | Common Stock |
| P. Daniel Van Plew | EVP & General Mgr, Industrial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 381.40 per share. | 09 Feb 2024 | 23,125 | 47,153 (0%) | 0% | 381.4 | 8,819,875 | Common Stock |
| Daniel P. Van Plew | EVP & General Mgr, Industrial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2024 | 23,125 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Fenimore Christopher R. | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 950.49 per share. | 09 Feb 2024 | 344 | 18,947 (0%) | 0% | 950.5 | 326,969 | Common Stock |
| Fenimore Christopher R. | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 952.62 per share. | 09 Feb 2024 | 1,046 | 17,414 (0%) | 0% | 952.6 | 996,441 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 951.39 per share. | 09 Feb 2024 | 487 | 18,460 (0%) | 0% | 951.4 | 463,327 | Common Stock |
| Christopher R. Fenimore | SVP Finance & CFO | Sale of securities on an exchange or to another person at price $ 954.57 per share. | 09 Feb 2024 | 1,100 | 14,972 (0%) | 0% | 954.6 | 1,050,027 | Common Stock |
| George Sing L. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 413.33 per share. | 08 Feb 2024 | 500 | 26,849 (0%) | 0% | 413.3 | 206,665 | Common Stock |
| L. Sing George | Director | Sale of securities on an exchange or to another person at price $ 945.00 per share. | 08 Feb 2024 | 500 | 26,349 (0%) | 0% | 945 | 472,500 | Common Stock |
| Sing George L. | Director | Sale of securities on an exchange or to another person at price $ 955.00 per share. | 08 Feb 2024 | 500 | 26,349 (0%) | 0% | 955 | 477,500 | Common Stock |
| Sing George L. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2024 | 500 | 9,838 | - | - | Non-Qualified Stock Option (right to buy) | |
| Sing George L. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Feb 2024 | 500 | 10,338 | - | - | Non-Qualified Stock Option (right to buy) | |
| George Sing L. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 413.33 per share. | 08 Feb 2024 | 500 | 26,849 (0%) | 0% | 413.3 | 206,665 | Common Stock |
| Stahl Neil | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 953.00 per share. | 07 Feb 2024 | 19 | 52,019 (0%) | 0% | 953 | 18,107 | Common Stock |
| Stahl Neil | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 951.49 per share. | 07 Feb 2024 | 1,237 | 53,097 (0%) | 0% | 951.5 | 1,176,993 | Common Stock |
| Stahl Neil | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 948.69 per share. | 07 Feb 2024 | 1,894 | 58,062 (0%) | 0% | 948.7 | 1,796,819 | Common Stock |
| Larosa Joseph J. | EVP General Counsel and Secret | Sale of securities on an exchange or to another person at price $ 950.00 per share. | 07 Feb 2024 | 1,000 | 38,543 (0%) | 0% | 950 | 950,000 | Common Stock |
| Neil Stahl | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 947.34 per share. | 07 Feb 2024 | 100 | 59,956 (0%) | 0% | 947.3 | 94,734 | Common Stock |
| Neil Stahl | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 952.49 per share. | 07 Feb 2024 | 1,059 | 52,038 (0%) | 0% | 952.5 | 1,008,687 | Common Stock |
| Neil Stahl | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 950.43 per share. | 07 Feb 2024 | 3,127 | 54,334 (0%) | 0% | 950.4 | 2,971,995 | Common Stock |
| Neil Stahl | EVP Research and Development | Sale of securities on an exchange or to another person at price $ 949.45 per share. | 07 Feb 2024 | 601 | 57,461 (0%) | 0% | 949.4 | 570,619 | Common Stock |
| Marion McCourt | EVP Commercial | Sale of securities on an exchange or to another person at price $ 934.71 per share. | 05 Feb 2024 | 1,000 | 13,789 (0%) | 0% | 934.7 | 934,710 | Common Stock |
| Stahl Neil | EVP Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2024 | 30,750 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Robert Landry E. | EVP Finance CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2024 | 400 | 11,787 | - | - | Non-Qualified Stock Option (right to buy) | |
| Landry E. Robert | EVP Finance CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 956.65 per share. | 02 Feb 2024 | 281 | 23,693 (0%) | 0% | 956.7 | 268,819 | Common Stock |
| Landry Robert E. | EVP Finance CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 378.98 per share. | 02 Feb 2024 | 400 | 23,974 (0%) | 0% | 379.0 | 151,592 | Common Stock |
| Stahl Neil | EVP Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 399.66 per share. | 02 Feb 2024 | 30,750 | 82,769 (0%) | 0% | 399.7 | 12,289,545 | Common Stock |
| Neil Stahl | EVP Research and Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 956.65 per share. | 02 Feb 2024 | 22,713 | 60,056 (0%) | 0% | 956.6 | 21,728,391 | Common Stock |
| Frederick Arthur Ryan | Director | Sale of securities on an exchange or to another person at price $ 955.40 per share. | 01 Feb 2024 | 10 | 18,429 (0%) | 0% | 955.4 | 9,554 | Common Stock |
| Arthur Ryan Frederick | Director | Sale of securities on an exchange or to another person at price $ 947.33 per share. | 01 Feb 2024 | 3 | 18,463 (0%) | 0% | 947.3 | 2,842 | Common Stock |
| Ryan Arthur Frederick | Director | Sale of securities on an exchange or to another person at price $ 945.00 per share. | 01 Feb 2024 | 1 | 18,466 (0%) | 0% | 945 | 945 | Common Stock |
| Marion McCourt | EVP Commercial | Sale of securities on an exchange or to another person at price $ 945.61 per share. | 01 Feb 2024 | 273 | 14,789 (0%) | 0% | 945.6 | 258,152 | Common Stock |
| Frederick Ryan Arthur | Director | Sale of securities on an exchange or to another person at price $ 954.60 per share. | 01 Feb 2024 | 5 | 18,439 (0%) | 0% | 954.6 | 4,773 | Common Stock |
| Arthur Ryan Frederick | Director | Sale of securities on an exchange or to another person at price $ 960.50 per share. | 01 Feb 2024 | 10 | 18,396 (0%) | 0% | 960.5 | 9,605 | Common Stock |
| Frederick Arthur Ryan | Director | Sale of securities on an exchange or to another person at price $ 958.60 per share. | 01 Feb 2024 | 5 | 18,414 (0%) | 0% | 958.6 | 4,793 | Common Stock |
| Ryan Frederick Arthur | Director | Sale of securities on an exchange or to another person at price $ 949.00 per share. | 01 Feb 2024 | 1 | 18,462 (0%) | 0% | 949 | 949 | Common Stock |
| Arthur Ryan Frederick | Director | Sale of securities on an exchange or to another person at price $ 940.00 per share. | 01 Feb 2024 | 1 | 18,481 (0%) | 0% | 940 | 940 | Common Stock |
| Arthur Ryan Frederick | Director | Sale of securities on an exchange or to another person at price $ 951.33 per share. | 01 Feb 2024 | 3 | 18,447 (0%) | 0% | 951.3 | 2,854 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 950.00 per share. | 01 Feb 2024 | 2 | 18,450 (0%) | 0% | 950 | 1,900 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 961.25 per share. | 01 Feb 2024 | 4 | 18,392 (0%) | 0% | 961.3 | 3,845 | Common Stock |
| Frederick Arthur Ryan | Director | Sale of securities on an exchange or to another person at price $ 957.67 per share. | 01 Feb 2024 | 3 | 18,419 (0%) | 0% | 957.7 | 2,873 | Common Stock |
| Arthur Ryan Frederick | Director | Sale of securities on an exchange or to another person at price $ 942.60 per share. | 01 Feb 2024 | 5 | 18,470 (0%) | 0% | 942.6 | 4,713 | Common Stock |
| Ryan Frederick Arthur | Director | Sale of securities on an exchange or to another person at price $ 953.33 per share. | 01 Feb 2024 | 3 | 18,444 (0%) | 0% | 953.3 | 2,860 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 959.62 per share. | 01 Feb 2024 | 8 | 18,406 (0%) | 0% | 959.6 | 7,677 | Common Stock |
| Arthur Frederick Ryan | Director | Sale of securities on an exchange or to another person at price $ 963.75 per share. | 01 Feb 2024 | 4 | 18,382 (0%) | 0% | 963.8 | 3,855 | Common Stock |
| Frederick Ryan Arthur | Director | Sale of securities on an exchange or to another person at price $ 956.14 per share. | 01 Feb 2024 | 7 | 18,422 (0%) | 0% | 956.1 | 6,693 | Common Stock |
| Frederick Arthur Ryan | Director | Sale of securities on an exchange or to another person at price $ 962.50 per share. | 01 Feb 2024 | 6 | 18,386 (0%) | 0% | 962.5 | 5,775 | Common Stock |
| Ryan Frederick Arthur | Director | Sale of securities on an exchange or to another person at price $ 949.50 per share. | 01 Feb 2024 | 10 | 18,452 (0%) | 0% | 949.5 | 9,495 | Common Stock |
| Ryan Frederick Arthur | Director | Sale of securities on an exchange or to another person at price $ 941.83 per share. | 01 Feb 2024 | 6 | 18,475 (0%) | 0% | 941.8 | 5,651 | Common Stock |
| Frederick Arthur Ryan | Director | Sale of securities on an exchange or to another person at price $ 943.67 per share. | 01 Feb 2024 | 3 | 18,467 (0%) | 0% | 943.7 | 2,831 | Common Stock |
| Landry Robert E. | EVP Finance CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 953.42 per share. | 31 Jan 2024 | 282 | 23,574 (0%) | 0% | 953.4 | 268,864 | Common Stock |
| E. Landry Robert | EVP Finance CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2024 | 400 | 12,187 | - | - | Non-Qualified Stock Option (right to buy) | |
| E. Landry Robert | EVP Finance CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 378.98 per share. | 31 Jan 2024 | 400 | 23,856 (0%) | 0% | 379.0 | 151,592 | Common Stock |
| Bonnie L. Bassler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 380.95 per share. | 30 Jan 2024 | 827 | 2,209 (0%) | 0% | 381.0 | 315,046 | Common Stock |
| L. Bonnie Bassler | Director | Sale of securities on an exchange or to another person at price $ 959.00 per share. | 30 Jan 2024 | 827 | 1,382 (0%) | 0% | 959 | 793,093 | Common Stock |
| Bonnie L. Bassler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 827 | 827 | - | - | Non-Qualified Stock Option (right to buy) | |
| Christopher R. Fenimore | SVP Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 555.67 per share. | 23 Jan 2024 | 5,000 | 21,860 (0%) | 0% | 555.7 | 2,778,350 | Common Stock |
| L. Joseph Goldstein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 625.60 per share. | 23 Jan 2024 | 2,707 | 9,089 (0%) | 0% | 625.6 | 1,693,499 | Common Stock |
| Christopher R. Fenimore | SVP Controller | Payment of exercise price or tax liability using portion of securities received from the company at price $ 948.50 per share. | 23 Jan 2024 | 3,986 | 17,874 (0%) | 0% | 948.5 | 3,780,721 | Common Stock |
| E. Robert Landry | EVP Finance CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 378.98 per share. | 23 Jan 2024 | 500 | 23,808 (0%) | 0% | 379.0 | 189,490 | Common Stock |
| Fenimore Christopher R. | SVP Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2024 | 5,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) |