4.7M
XNAS Volume
High volume+gain today
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| William Ho | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 450,000 | 450,000 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 515,000 | 515,000 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 1,746,000 | 1,746,000 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 75,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 56,000 | 56,000 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 75,000 | 75,000 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 7,807 | 0 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 7,807 | 7,807 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 20,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 20,000 | 20,000 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 55,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 55,000 | 55,000 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 55,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 55,000 | 55,000 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 56,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 20,000 | 20,000 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 75,000 | 75,000 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | CHIEF SCIENTIFIC OFFICER | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 75,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 56,000 | 56,000 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | CHIEF SCIENTIFIC OFFICER | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 56,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 55,000 | 55,000 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | CHIEF SCIENTIFIC OFFICER | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 55,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 50,000 | 50,000 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | CHIEF SCIENTIFIC OFFICER | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 50,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | CHIEF SCIENTIFIC OFFICER | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 20,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 275,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 83,333 | 0 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 83,333 | 83,333 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 60,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 60,000 | 60,000 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 150,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 300,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 300,000 | 300,000 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Sale or transfer of securities back to the company at price $ 0.00 per share. | 13 Nov 2024 | 250,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 250,000 | 250,000 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Nov 2024 | 275,000 | 275,000 | - | - | Employee Stock Option (right to buy) | |
| Michael F. Giordano | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 36,490 | 36,490 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 36,490 | 36,490 | - | - | Stock Option (right to buy) | |
| William J. Rieflin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 36,490 | 36,490 | - | - | Stock Option (right to buy) | |
| Lori Lyons-Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 36,490 | 36,490 | - | - | Stock Option (right to buy) | |
| Linda Kozick | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 36,490 | 36,490 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 36,490 | 36,490 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Mar 2024 | 8,574 | 8,574 | - | - | Stock Option (right to buy) | |
| William J. Rieflin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Mar 2024 | 11,871 | 11,871 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Mar 2024 | 6,925 | 6,925 | - | - | Stock Option (right to buy) | |
| G. Brockstedt Dirk | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 75,000 | 75,000 | - | - | Employee Stock Option (right to buy) | |
| Wong Brian Russell | Director, PRESIDENT AND CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 275,000 | 275,000 | - | - | Employee Stock Option (right to buy) | |
| William Ho | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 75,000 | 75,000 | - | - | Employee Stock Option (right to buy) | |
| Brockstedt Dirk G. | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 22.78 per share. | 05 Jan 2024 | 898 | 27,820 (0%) | 0% | 22.8 | 20,456 | Common Stock |
| Brockstedt Dirk G. | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Dec 2023 | 8,000 | 7,690 | - | - | Employee Stock Option (right to buy) | |
| G. Brockstedt Dirk | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 29 Dec 2023 | 8,000 | 27,070 (0%) | 0% | 6.2 | 49,440 | Common Stock |
| Ho William | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 21.68 per share. | 21 Dec 2023 | 2,500 | 15,020 (0%) | 0% | 21.7 | 54,200 | Common Stock |
| William Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.92 per share. | 18 Aug 2023 | 2,500 | 21,289 (0%) | 0% | 18.9 | 47,300 | Common Stock |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jul 2023 | 460 | 1,841 | - | - | Employee Stock Option (right to buy) | |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.00 per share. | 28 Jul 2023 | 460 | 23,789 (0%) | 0% | 12 | 5,520 | Common Stock |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.00 per share. | 23 Jun 2023 | 920 | 23,329 (0%) | 0% | 12 | 11,040 | Common Stock |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jun 2023 | 920 | 2,301 | - | - | Employee Stock Option (right to buy) | |
| Michael F. Giordano | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 12,940 | 12,940 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 12,940 | 12,940 | - | - | Stock Option (right to buy) | |
| William J. Rieflin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 12,940 | 12,940 | - | - | Stock Option (right to buy) | |
| Lori Lyons-Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 12,940 | 12,940 | - | - | Stock Option (right to buy) | |
| Linda Kozick | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 12,940 | 12,940 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 12,940 | 12,940 | - | - | Stock Option (right to buy) | |
| William Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.88 per share. | 19 Apr 2023 | 5,000 | 20,992 (0%) | 0% | 18.9 | 94,400 | Common Stock |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Apr 2023 | 460 | 3,802 | - | - | Employee Stock Option (right to buy) | |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.00 per share. | 13 Apr 2023 | 460 | 22,381 (0%) | 0% | 12 | 5,520 | Common Stock |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 4,477 | 4,477 | - | - | Stock Option (right to buy) | |
| William J. Rieflin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 6,026 | 6,026 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 3,616 | 3,616 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 20.05 per share. | 14 Mar 2023 | 2,500 | 6,500 (0%) | 0% | 20.1 | 50,125 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 19.95 per share. | 14 Mar 2023 | 600 | 14,900 (0%) | 0% | 20.0 | 11,970 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 18.48 per share. | 14 Mar 2023 | 400 | 14,300 (0%) | 0% | 18.5 | 7,392 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 18.75 per share. | 14 Mar 2023 | 1,500 | 13,900 (0%) | 0% | 18.8 | 28,125 | Common Stock |
| William Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.62 per share. | 07 Mar 2023 | 5,000 | 25,532 (0%) | 0% | 29.6 | 148,100 | Common Stock |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.00 per share. | 03 Mar 2023 | 460 | 30,532 (0%) | 0% | 12 | 5,520 | Common Stock |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 460 | 3,681 | - | - | Option (right to buy) | |
| William Ho | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 56,000 | 56,000 | - | - | Employee Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 56,000 | 56,000 | - | - | Employee Stock Option (right to buy) | |
| Brian Russell Wong | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 250,000 | 250,000 | - | - | Employee Stock Option (right to buy) | |
| William Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 24 Jan 2023 | 5,000 | 30,072 (0%) | 0% | 30 | 150,000 | Common Stock |
| William Ho | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 25.56 per share. | 19 Jan 2023 | 5,000 | 35,072 (0%) | 0% | 25.6 | 127,800 | Common Stock |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 12 Jan 2023 | 1,042 | 38,692 (0%) | 0% | 6.3 | 6,565 | Common Stock |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jan 2023 | 1,380 | 4,601 | - | - | Option (right to buy) | |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jan 2023 | 1,042 | 0 | - | - | Option (right to buy) | |
| William Ho | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.00 per share. | 12 Jan 2023 | 1,380 | 40,072 (0%) | 0% | 12 | 16,560 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 21.97 per share. | 05 Jan 2023 | 742 | 19,070 (0%) | 0% | 22.0 | 16,299 | Common Stock |
| Michael F. Giordano | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2022 | 8,500 | 8,500 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2022 | 8,500 | 8,500 | - | - | Stock Option (right to buy) | |
| William J. Rieflin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2022 | 8,500 | 8,500 | - | - | Stock Option (right to buy) | |
| Lori Lyons-Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2022 | 8,500 | 8,500 | - | - | Stock Option (right to buy) | |
| Linda Kozick | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2022 | 8,500 | 8,500 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2022 | 8,500 | 8,500 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 11.80 per share. | 10 May 2022 | 2,500 | 13,800 (0%) | 0% | 11.8 | 29,500 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 10.54 per share. | 10 May 2022 | 2,000 | 11,300 (0%) | 0% | 10.5 | 21,080 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 10.62 per share. | 10 May 2022 | 400 | 4,000 (0%) | 0% | 10.6 | 4,248 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 10.49 per share. | 10 May 2022 | 600 | 3,600 (0%) | 0% | 10.5 | 6,294 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 10.51 per share. | 10 May 2022 | 1,000 | 3,000 (0%) | 0% | 10.5 | 10,510 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 11.30 per share. | 10 May 2022 | 500 | 1,800 (0%) | 0% | 11.3 | 5,650 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 15.05 per share. | 04 May 2022 | 720 | 19,812 (0%) | 0% | 15.1 | 10,836 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 23.05 per share. | 11 Apr 2022 | 2,647 | 19,812 (0%) | 0% | 23.0 | 61,013 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 11 Apr 2022 | 2,647 | 22,459 (0%) | 0% | 6.2 | 16,358 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Apr 2022 | 1,290 | 2,113 | - | - | Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Apr 2022 | 1,357 | 15,690 | - | - | Option (right to buy) | |
| Michael F. Giordano | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 3,213 | 3,213 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 3,868 | 3,868 | - | - | Stock Option (right to buy) | |
| William J. Rieflin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 5,207 | 5,207 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2022 | 3,124 | 3,124 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 23.91 per share. | 11 Mar 2022 | 2,648 | 19,812 (0%) | 0% | 23.9 | 63,314 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 11 Mar 2022 | 2,648 | 22,460 (0%) | 0% | 6.2 | 16,365 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2022 | 2,648 | 17,047 | - | - | Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Feb 2022 | 2,647 | 19,695 | - | - | Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 11 Feb 2022 | 2,647 | 22,459 (0%) | 0% | 6.2 | 16,358 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 22.47 per share. | 11 Feb 2022 | 2,647 | 19,812 (0%) | 0% | 22.5 | 59,478 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2022 | 55,000 | 55,000 | - | - | Stock Option (right to buy) | |
| Brian Russell Wong | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2022 | 300,000 | 300,000 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 11 Jan 2022 | 2,648 | 22,460 (0%) | 0% | 6.2 | 16,365 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 32.16 per share. | 11 Jan 2022 | 2,648 | 19,812 (0%) | 0% | 32.2 | 85,160 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jan 2022 | 2,648 | 22,342 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 36.73 per share. | 03 Jan 2022 | 820 | 18,992 (0%) | 0% | 36.7 | 30,119 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 30.88 per share. | 10 Dec 2021 | 2,647 | 19,812 (0%) | 0% | 30.9 | 81,739 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2021 | 2,647 | 611 | - | - | Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 10 Dec 2021 | 2,647 | 22,459 (0%) | 0% | 6.3 | 16,676 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 11 Nov 2021 | 2,648 | 22,460 (0%) | 0% | 6.3 | 16,682 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Nov 2021 | 2,648 | 3,258 | - | - | Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.69 per share. | 11 Nov 2021 | 2,648 | 19,812 (0%) | 0% | 35.7 | 94,507 | Common Stock |
| Lori Lyons-Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Nov 2021 | 22,500 | 22,500 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 30.70 per share. | 18 Oct 2021 | 500 | 9,300 (0%) | 0% | 30.7 | 15,350 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 29.69 per share. | 13 Oct 2021 | 400 | 8,800 (0%) | 0% | 29.7 | 11,876 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 30.78 per share. | 11 Oct 2021 | 2,647 | 19,812 (0%) | 0% | 30.8 | 81,475 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Oct 2021 | 2,647 | 24,990 | - | - | Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 11 Oct 2021 | 2,647 | 22,459 (0%) | 0% | 6.2 | 16,358 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.78 per share. | 10 Sep 2021 | 2,648 | 19,812 (0%) | 0% | 35.8 | 94,745 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2021 | 2,648 | 27,637 | - | - | Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 10 Sep 2021 | 2,648 | 22,460 (0%) | 0% | 6.2 | 16,365 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 31.11 per share. | 23 Aug 2021 | 500 | 500 (0%) | 0% | 31.1 | 15,557 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 30.80 per share. | 23 Aug 2021 | 25 | 2,000 (0%) | 0% | 30.8 | 770 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 31.00 per share. | 23 Aug 2021 | 500 | 1,975 (0%) | 0% | 31 | 15,500 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 31.00 per share. | 23 Aug 2021 | 225 | 1,475 (0%) | 0% | 31 | 6,975 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 32.05 per share. | 23 Aug 2021 | 250 | 1,250 (0%) | 0% | 32.1 | 8,013 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 31.50 per share. | 23 Aug 2021 | 500 | 1,000 (0%) | 0% | 31.5 | 15,750 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 29.82 per share. | 20 Aug 2021 | 100 | 7,900 (0%) | 0% | 29.8 | 2,982 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 29.47 per share. | 20 Aug 2021 | 500 | 8,400 (0%) | 0% | 29.5 | 14,735 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 11 Aug 2021 | 2,647 | 22,459 (0%) | 0% | 6.2 | 16,358 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 31.19 per share. | 11 Aug 2021 | 2,647 | 19,812 (0%) | 0% | 31.2 | 82,560 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Aug 2021 | 2,647 | 30,285 | - | - | Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 12 Jul 2021 | 2,648 | 22,460 (0%) | 0% | 6.2 | 16,365 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jul 2021 | 2,648 | 32,932 | - | - | Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 33.53 per share. | 12 Jul 2021 | 2,648 | 19,812 (0%) | 0% | 33.5 | 88,787 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 30.20 per share. | 07 Jul 2021 | 600 | 7,400 (0%) | 0% | 30.2 | 18,120 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 30.15 per share. | 07 Jul 2021 | 400 | 7,800 (0%) | 0% | 30.2 | 12,060 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 31.54 per share. | 16 Jun 2021 | 500 | 6,600 (0%) | 0% | 31.5 | 15,770 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 31.60 per share. | 16 Jun 2021 | 5 | 305 (0%) | 0% | 31.6 | 158 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 31.53 per share. | 16 Jun 2021 | 100 | 6,800 (0%) | 0% | 31.5 | 3,153 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 31.56 per share. | 16 Jun 2021 | 100 | 6,700 (0%) | 0% | 31.6 | 3,156 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jun 2021 | 2,647 | 35,580 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 11 Jun 2021 | 2,647 | 22,459 (0%) | 0% | 6.2 | 16,358 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 18.55 per share. | 11 Jun 2021 | 2,647 | 19,812 (0%) | 0% | 18.6 | 49,102 | Common Stock |
| Michael F. Giordano | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2021 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2021 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| William J. Rieflin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2021 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Peter Svennilson | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2021 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Linda Kozick | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2021 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2021 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 11 May 2021 | 2,648 | 22,460 (0%) | 0% | 6.2 | 16,365 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2021 | 2,648 | 38,227 | - | - | Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 18.19 per share. | 11 May 2021 | 2,648 | 19,812 (0%) | 0% | 18.2 | 48,167 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 21.56 per share. | 05 May 2021 | 2,084 | 19,812 (0%) | 0% | 21.6 | 44,931 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 19.40 per share. | 13 Apr 2021 | 300 | 6,100 (0%) | 0% | 19.4 | 5,820 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 19.50 per share. | 13 Apr 2021 | 400 | 5,800 (0%) | 0% | 19.5 | 7,800 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 21.07 per share. | 09 Apr 2021 | 74 | 5,100 (0%) | 0% | 21.1 | 1,559 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 21.09 per share. | 09 Apr 2021 | 500 | 1,300 (0%) | 0% | 21.1 | 10,545 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 20.95 per share. | 09 Apr 2021 | 300 | 800 (0%) | 0% | 21.0 | 6,286 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 21.24 per share. | 09 Apr 2021 | 300 | 5,400 (0%) | 0% | 21.2 | 6,372 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 21.00 per share. | 09 Apr 2021 | 100 | 5,026 (0%) | 0% | 21 | 2,100 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 21.00 per share. | 09 Apr 2021 | 21 | 4,926 (0%) | 0% | 21 | 441 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 20.99 per share. | 09 Apr 2021 | 79 | 4,905 (0%) | 0% | 21.0 | 1,658 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 20.92 per share. | 09 Apr 2021 | 26 | 4,826 (0%) | 0% | 20.9 | 544 | Common Stock |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2021 | 3,822 | 3,822 | - | - | Stock Option (right to buy) | |
| Peter Svennilson | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2021 | 2,229 | 2,229 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2021 | 3,025 | 3,025 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 21.22 per share. | 16 Feb 2021 | 9,877 | 19,812 (0%) | 0% | 21.2 | 209,590 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 16 Feb 2021 | 8,245 | 28,057 (0%) | 0% | 6.3 | 51,944 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 16 Feb 2021 | 1,632 | 29,689 (0%) | 0% | 6.2 | 10,086 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2021 | 8,245 | 5,906 | - | - | Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2021 | 1,632 | 3,403 | - | - | Option (right to buy) | |
| Wendye Robbins | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 11 Feb 2021 | 300 | 300 (0%) | 0% | 0 | Common Stock | |
| Wendye Robbins | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 11 Feb 2021 | 300 | 4,800 (0%) | 0% | 0 | Common Stock | |
| Dirk G. Brockstedt | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2021 | 50,000 | 50,000 | - | - | Stock Option (right to buy) | |
| Brian Russell Wong | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2021 | 150,000 | 150,000 | - | - | Stock Option (right to buy) | |
| Karen C. Lam | VP, Finance and Controller | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jan 2021 | 18,000 | 18,000 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 19.76 per share. | 05 Jan 2021 | 821 | 18,735 (0%) | 0% | 19.8 | 16,225 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 05 Jan 2021 | 1,179 | 17,556 (0%) | 0% | 19.7 | 23,203 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Dec 2020 | 9,300 | 45,910 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 30 Dec 2020 | 9,300 | 19,556 (0%) | 0% | 6.2 | 57,474 | Common Stock |
| William J. Rieflin | Director | Purchase of securities on an exchange or from another person at price $ 16.22 per share. | 19 Nov 2020 | 10,000 | 18,000 (0%) | 0% | 16.2 | 162,200 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 16.09 per share. | 19 Nov 2020 | 500 | 500 (0%) | 0% | 16.1 | 8,045 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 16.08 per share. | 19 Nov 2020 | 500 | 5,100 (0%) | 0% | 16.1 | 8,040 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 16 Nov 2020 | 6,508 | 20,133 (0%) | 0% | 6.3 | 41,000 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Nov 2020 | 6,508 | 14,151 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Nov 2020 | 3,369 | 5,035 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 17.01 per share. | 16 Nov 2020 | 9,877 | 10,256 (0%) | 0% | 17.0 | 168,008 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 16 Nov 2020 | 3,369 | 13,625 (0%) | 0% | 6.2 | 20,820 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.06 per share. | 02 Nov 2020 | 1,910 | 10,256 (0%) | 0% | 28.1 | 53,595 | Common Stock |
| Karen C. Lam | VP, Finance and Controller | Sale of securities on an exchange or to another person at price $ 28.14 per share. | 02 Nov 2020 | 2,022 | 12,735 (0%) | 0% | 28.1 | 56,899 | Common Stock |
| Brian Russell Wong | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 40.05 per share. | 12 Oct 2020 | 20,000 | 337,000 (1%) | 0% | 40.1 | 801,040 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 28.55 per share. | 28 Sep 2020 | 200 | 6,550 (0%) | 0% | 28.6 | 5,710 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 28.80 per share. | 28 Sep 2020 | 300 | 6,350 (0%) | 0% | 28.8 | 8,640 | Common Stock |
| Brian Russell Wong | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 30.06 per share. | 23 Sep 2020 | 2,000 | 357,000 (1%) | 0% | 30.1 | 60,120 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 29.50 per share. | 23 Sep 2020 | 100 | 5,850 (0%) | 0% | 29.5 | 2,950 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 29.10 per share. | 23 Sep 2020 | 300 | 5,750 (0%) | 0% | 29.1 | 8,730 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 28.00 per share. | 23 Sep 2020 | 200 | 6,050 (0%) | 0% | 28 | 5,600 | Common Stock |
| Peter Svennilson | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 30.85 per share. | 22 Sep 2020 | 608,000 | 3,835,679 (15%) | 2% | 30.9 | 18,756,800 | Common Stock |
| Peter Svennilson | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 22.75 per share. | 17 Aug 2020 | 538,654 | 4,443,679 (18%) | 2% | 22.8 | 12,254,379 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 23.13 per share. | 17 Aug 2020 | 1,502 | 18,631 (0%) | 0% | 23.1 | 34,741 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 24.07 per share. | 17 Aug 2020 | 8,375 | 10,256 (0%) | 0% | 24.1 | 201,586 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2020 | 9,877 | 58,579 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 17 Aug 2020 | 9,877 | 20,133 (0%) | 0% | 6.2 | 61,040 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 22.75 per share. | 24 Jul 2020 | 400 | 5,450 (0%) | 0% | 22.8 | 9,100 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 22.25 per share. | 24 Jul 2020 | 500 | 5,050 (0%) | 0% | 22.3 | 11,125 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 26.30 per share. | 29 Jun 2020 | 500 | 4,100 (0%) | 0% | 26.3 | 13,150 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 26.50 per share. | 29 Jun 2020 | 500 | 4,600 (0%) | 0% | 26.5 | 13,250 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 26.02 per share. | 29 Jun 2020 | 1,650 | 3,600 (0%) | 0% | 26.0 | 42,933 | Common Stock |
| Michael F. Giordano | Director | Sale of securities on an exchange or to another person at price $ 33.37 per share. | 25 Jun 2020 | 19,013 | 0 (0%) | 0% | 33.4 | 634,464 | Common Stock |
| Michael F. Giordano | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.00 per share. | 25 Jun 2020 | 8,944 | 8,944 (0%) | 0% | 12 | 107,328 | Common Stock |
| Michael F. Giordano | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 25 Jun 2020 | 10,069 | 10,069 (0%) | 0% | 6.2 | 62,226 | Common Stock |
| Michael F. Giordano | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2020 | 8,944 | 6,390 | - | - | Stock Option (right to buy) | |
| Michael F. Giordano | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2020 | 10,069 | 6,597 | - | - | Stock Option (right to buy) | |
| Karen C. Lam | VP, Finance & Controller | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 25 Jun 2020 | 875 | 12,735 (0%) | 0% | 35 | 30,625 | Common Stock |
| Michael F. Giordano | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| William J. Rieflin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Peter Svennilson | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 22,500 | 22,500 | - | - | Stock Option (right to buy) | |
| Linda Kozick | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2020 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 15 May 2020 | 9,877 | 10,256 (0%) | 0% | 15 | 148,155 | Common Stock |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2020 | 9,877 | 68,456 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.18 per share. | 15 May 2020 | 9,877 | 20,133 (0%) | 0% | 6.2 | 61,040 | Common Stock |
| Karen C. Lam | VP, Finance & Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 12 May 2020 | 2,777 | 13,610 (0%) | 0% | 1.9 | 5,165 | Common Stock |
| Karen C. Lam | VP, Finance & Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2020 | 2,777 | 5,556 | - | - | Stock option (right to buy) | |
| Karen C. Lam | VP, Finance & Controller | Sale of securities on an exchange or to another person at price $ 15.40 per share. | 07 May 2020 | 1,831 | 10,833 (0%) | 0% | 15.4 | 28,197 | Common Stock |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2020 | 3,984 | 3,984 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2020 | 3,154 | 3,154 | - | - | Stock Option (right to buy) | |
| Dirk G. Brockstedt | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2020 | 8,000 | 8,000 (0%) | 0% | 0 | Common Stock | |
| Dirk G. Brockstedt | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2020 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Brian Russell Wong | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2020 | 22,000 | 147,000 (0%) | 0% | 0 | Common Stock | |
| Brian Russell Wong | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2020 | 60,000 | 60,000 | - | - | Stock Option (right to buy) | |
| Karen C. Lam | VP, Finance & Controller | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2020 | 2,500 | 10,833 (0%) | 0% | 0 | Common Stock | |
| Karen C. Lam | VP, Finance & Controller | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2020 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | 31 Dec 2019 | 22 | 1,950 (0%) | 0% | 23.1 | 508 | Common Stock | |
| Wendye Robbins | Director | 31 Dec 2019 | 200 | 1,928 (0%) | 0% | 21.9 | 4,374 | Common Stock | |
| Wendye Robbins | Director | 31 Dec 2019 | 78 | 1,728 (0%) | 0% | 26.6 | 2,075 | Common Stock | |
| Wendye Robbins | Director | 31 Dec 2019 | 50 | 1,650 (0%) | 0% | 12.8 | 638 | Common Stock | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2019 | 22,500 | 22,500 | - | - | Stock Option (right to buy) | |
| David V. Goeddel | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 12.00 per share. | 04 Nov 2019 | 625,000 | 4,982,333 (20%) | 2% | 12 | 7,500,000 | Common Stock |
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 1,454,016 | 1,454,016 (5%) | 6% | - | Common Stock | ||
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 145,401 | 1,599,417 (6%) | 0% | - | Common Stock | ||
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 145,401 | 145,401 (0%) | 0% | - | Common Stock | ||
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 14,781,963 | 0 | - | - | Series A Preferred Stock | ||
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 7,000,000 | 0 | - | - | Series B Preferred Stock | ||
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 4,362,050 | 0 | - | - | Series C Preferred Stock | ||
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 872,410 | 0 | - | - | Series C-2 Preferred Stock | ||
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 872,410 | 0 | - | - | Series C-2 Preferred Stock | ||
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 8,724,100 | 0 | - | - | Series C Preferred Stock | ||
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 2,463,659 | 2,463,659 (10%) | 11% | - | Common Stock | ||
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 1,166,666 | 3,630,325 (14%) | 5% | - | Common Stock | ||
| David V. Goeddel | Director, Ten Percent Owner | 04 Nov 2019 | 727,008 | 4,357,333 (17%) | 3% | - | Common Stock | ||
| William J. Rieflin | Director | 04 Nov 2019 | 16,666 | 76,722 (0%) | 0% | - | Common Stock | ||
| William J. Rieflin | Director | 04 Nov 2019 | 43,390 | 60,056 (0%) | 0% | - | Common Stock | ||
| William J. Rieflin | Director | 04 Nov 2019 | 100,000 | 0 | - | - | Series B Preferred Stock | ||
| William J. Rieflin | Director | 04 Nov 2019 | 260,344 | 0 | - | - | Series A Preferred Stock | ||
| William J. Rieflin | Director | Purchase of securities on an exchange or from another person at price $ 12.00 per share. | 04 Nov 2019 | 8,000 | 8,000 (0%) | 0% | 12 | 96,000 | Common Stock |
| Brian Russell Wong | Director, President and CEO | 04 Nov 2019 | 150,000 | 0 | - | - | Series B Preferred Stock | ||
| Brian Russell Wong | Director, President and CEO | 04 Nov 2019 | 25,000 | 355,000 (1%) | 0% | - | Common Stock | ||
| Brian Russell Wong | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 12.00 per share. | 04 Nov 2019 | 25,000 | 125,000 (0%) | 0% | 12 | 300,000 | Common Stock |
| Wendye Robbins | Director | Purchase of securities on an exchange or from another person at price $ 12.00 per share. | 04 Nov 2019 | 1,600 | 1,600 (0%) | 0% | 12 | 19,200 | Common Stock |
| Michael F. Giordano | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Oct 2019 | 15,334 | 15,334 | - | - | Stock Option (right to buy) | |
| William J. Rieflin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Oct 2019 | 3,333 | 3,333 | - | - | Stock Option (right to buy) | |
| William J. Rieflin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Oct 2019 | 15,334 | 15,334 | - | - | Stock Option (right to buy) | |
| Brian Russell Wong | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Oct 2019 | 83,333 | 83,333 | - | - | Stock Option (right to buy) | |
| Linda Kozick | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Oct 2019 | 3,333 | 3,333 | - | - | Stock Option (right to buy) | |
| Linda Kozick | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Oct 2019 | 15,334 | 15,334 | - | - | Stock Option (right to buy) | |
| Wendye Robbins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Oct 2019 | 32,000 | 32,000 | - | - | Stock Option (right to buy) |