28.27 1.01 (3.71%)
1.8M XNYS Volume
XNYS 17 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.76 per share. | 06 Mar 2025 | 886 | 39,859 (0%) | 0% | 27.8 | 24,595 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.68 per share. | 06 Mar 2025 | 2,300 | 42,159 (0%) | 0% | 28.7 | 65,964 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.68 per share. | 06 Mar 2025 | 693 | 41,466 (0%) | 0% | 28.7 | 19,875 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2025 | 6,755 | 6,755 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Sale of securities on an exchange or to another person at price $ 27.44 per share. | 06 Mar 2025 | 7,800 | 33,666 (0%) | 0% | 27.4 | 214,032 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 2,300 | 2,299 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 2,941 | 0 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Grant, award, or other acquisition of securities at price $ 27.76 per share. | 06 Mar 2025 | 17,355 | 43,028 (0%) | 0% | 27.8 | 481,775 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.76 per share. | 06 Mar 2025 | 5,224 | 37,804 (0%) | 0% | 27.8 | 145,018 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.76 per share. | 06 Mar 2025 | 2,941 | 40,745 (0%) | 0% | 27.8 | 81,642 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2025 | 5,485 | 5,485 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 2,163 | 0 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2025 | 1,759 | 1,758 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Grant, award, or other acquisition of securities at price $ 27.76 per share. | 06 Mar 2025 | 12,762 | 44,232 (0%) | 0% | 27.8 | 354,273 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.76 per share. | 06 Mar 2025 | 6,650 | 37,582 (0%) | 0% | 27.8 | 184,604 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.76 per share. | 06 Mar 2025 | 2,163 | 39,745 (0%) | 0% | 27.8 | 60,045 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.76 per share. | 06 Mar 2025 | 1,127 | 38,618 (0%) | 0% | 27.8 | 31,286 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.68 per share. | 06 Mar 2025 | 1,759 | 40,377 (0%) | 0% | 28.7 | 50,448 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.68 per share. | 06 Mar 2025 | 917 | 39,460 (0%) | 0% | 28.7 | 26,300 | Ordinary Shares |
| Patrick Lockwood-Taylor | Director, CEO | Grant, award, or other acquisition of securities at price $ 27.76 per share. | 06 Mar 2025 | 16,389 | 61,798 (0%) | 0% | 27.8 | 454,959 | Ordinary Shares |
| Patrick Lockwood-Taylor | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.76 per share. | 06 Mar 2025 | 5,925 | 55,873 (0%) | 0% | 27.8 | 164,478 | Ordinary Shares |
| Patrick Lockwood-Taylor | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2025 | 23,454 | 23,454 | - | - | Restricted Stock Units | |
| Julia M. Brown | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.47 per share. | 05 Mar 2025 | 5,548 | 5,548 (0%) | 0% | 29.5 | 163,500 | Ordinary Shares |
| Julia M. Brown | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.47 per share. | 05 Mar 2025 | 2,664 | 2,884 (0%) | 0% | 29.5 | 78,508 | Ordinary Shares |
| Julia M. Brown | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2025 | 5,548 | 0 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Sale of securities on an exchange or to another person at price $ 28.27 per share. | 09 Dec 2024 | 17,598 | 5,409 (0%) | 0% | 28.3 | 497,495 | Ordinary Shares |
| Katherine C. Doyle | Director | Sale of securities on an exchange or to another person at price $ 27.30 per share. | 13 Sep 2024 | 8,954 | 6,009 (0%) | 0% | 27.3 | 244,444 | Ordinary Shares |
| David Ball | EVP & CBDO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Sep 2024 | 15,402 | 15,402 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Sale of securities on an exchange or to another person at price $ 29.40 per share. | 26 Aug 2024 | 13,000 | 20,553 (0%) | 0% | 29.4 | 382,246 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Sale of securities on an exchange or to another person at price $ 27.42 per share. | 20 Aug 2024 | 6,683 | 7,000 (0%) | 0% | 27.4 | 183,281 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Sale of securities on an exchange or to another person at price $ 27.46 per share. | 20 Aug 2024 | 7,800 | 73,553 (0%) | 0% | 27.5 | 214,149 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Sale of securities on an exchange or to another person at price $ 27.86 per share. | 20 Aug 2024 | 20,500 | 81,353 (0%) | 0% | 27.9 | 571,130 | Ordinary Shares |
| Patrick Lockwood-Taylor | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.16 per share. | 10 Jul 2024 | 28,326 | 48,826 (0%) | 0% | 27.2 | 769,334 | Ordinary Shares |
| Patrick Lockwood-Taylor | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2024 | 28,326 | 56,651 | - | - | Restricted Stock Units | |
| Patrick Lockwood-Taylor | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.16 per share. | 10 Jul 2024 | 4,280 | 45,409 (0%) | 0% | 27.2 | 116,245 | Ordinary Shares |
| Patrick Lockwood-Taylor | Director, CEO | Grant, award, or other acquisition of securities at price $ 27.16 per share. | 10 Jul 2024 | 11,837 | 49,689 (0%) | 0% | 27.2 | 321,493 | Ordinary Shares |
| Patrick Lockwood-Taylor | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.16 per share. | 10 Jul 2024 | 10,974 | 37,852 (0%) | 0% | 27.2 | 298,054 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 25.72 per share. | 08 Jul 2024 | 920 | 18,930 (0%) | 0% | 25.7 | 23,662 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.72 per share. | 08 Jul 2024 | 479 | 18,451 (0%) | 0% | 25.7 | 12,320 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2024 | 920 | 919 | - | - | Restricted Stock Units | |
| Todd W. Kingma | Executive VP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2024 | 21,715 | 21,715 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Purchase of securities on an exchange or from another person at price $ 27.90 per share. | 28 May 2024 | 1,000 | 101,853 (0%) | 0% | 27.9 | 27,900 | Ordinary Shares |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.22 per share. | 14 May 2024 | 8,764 | 27,214 (0%) | 0% | 30.2 | 264,848 | Ordinary Shares |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 8,764 | 0 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2024 | 9,904 | 9,904 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 30.22 per share. | 14 May 2024 | 4,207 | 23,007 (0%) | 0% | 30.2 | 127,136 | Ordinary Shares |
| Orlando D. Ashford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 10,955 | 0 | - | - | Restricted Stock Units | |
| Orlando D. Ashford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.22 per share. | 14 May 2024 | 10,955 | 20,992 (0%) | 0% | 30.2 | 331,060 | Ordinary Shares |
| Orlando D. Ashford | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 30.22 per share. | 14 May 2024 | 5,259 | 15,733 (0%) | 0% | 30.2 | 158,927 | Ordinary Shares |
| Orlando D. Ashford | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2024 | 12,380 | 12,380 | - | - | Restricted Stock Units | |
| Geoffrey M. Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2024 | 9,904 | 9,904 | - | - | Restricted Stock Units | |
| Geoffrey M. Parker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.22 per share. | 14 May 2024 | 8,764 | 24,469 (0%) | 0% | 30.2 | 264,848 | Ordinary Shares |
| Geoffrey M. Parker | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 30.22 per share. | 14 May 2024 | 4,207 | 20,262 (0%) | 0% | 30.2 | 127,136 | Ordinary Shares |
| Geoffrey M. Parker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 8,764 | 0 | - | - | Restricted Stock Units | |
| Bradley A. Alford | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2024 | 9,904 | 9,904 | - | - | Restricted Stock Units | |
| Bradley A. Alford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 8,764 | 0 | - | - | Restricted Stock Units | |
| Bradley A. Alford | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 30.22 per share. | 14 May 2024 | 4,207 | 36,010 (0%) | 0% | 30.2 | 127,136 | Ordinary Shares |
| Bradley A. Alford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.22 per share. | 14 May 2024 | 8,764 | 40,217 (0%) | 0% | 30.2 | 264,848 | Ordinary Shares |
| Donal O'Connor | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 8,764 | 0 | - | - | Restricted Stock Units | |
| Donal O'Connor | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.22 per share. | 14 May 2024 | 8,764 | 29,694 (0%) | 0% | 30.2 | 264,848 | Ordinary Shares |
| Donal O'Connor | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 30.22 per share. | 14 May 2024 | 4,207 | 25,487 (0%) | 0% | 30.2 | 127,136 | Ordinary Shares |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2024 | 9,904 | 9,904 | - | - | Restricted Stock Units | |
| Katherine C. Doyle | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 8,764 | 0 | - | - | Restricted Stock Units | |
| Katherine C. Doyle | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.22 per share. | 14 May 2024 | 8,764 | 19,170 (0%) | 0% | 30.2 | 264,848 | Ordinary Shares |
| Katherine C. Doyle | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 30.22 per share. | 14 May 2024 | 4,207 | 14,963 (0%) | 0% | 30.2 | 127,136 | Ordinary Shares |
| Katherine C. Doyle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2024 | 9,904 | 9,904 | - | - | Restricted Stock Units | |
| Adriana Karaboutis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.22 per share. | 14 May 2024 | 8,764 | 26,686 (0%) | 0% | 30.2 | 264,848 | Ordinary Shares |
| Adriana Karaboutis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 8,764 | 0 | - | - | Restricted Stock Units | |
| Adriana Karaboutis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2024 | 9,904 | 9,904 | - | - | Restricted Stock Units | |
| Adriana Karaboutis | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 30.22 per share. | 14 May 2024 | 4,207 | 22,479 (0%) | 0% | 30.2 | 127,136 | Ordinary Shares |
| Erica L. Mann | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2024 | 9,904 | 9,904 | - | - | Restricted Stock Units | |
| Erica L. Mann | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.22 per share. | 14 May 2024 | 8,764 | 21,665 (0%) | 0% | 30.2 | 264,848 | Ordinary Shares |
| Erica L. Mann | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 30.22 per share. | 14 May 2024 | 4,207 | 17,458 (0%) | 0% | 30.2 | 127,136 | Ordinary Shares |
| Erica L. Mann | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 8,764 | 0 | - | - | Restricted Stock Units | |
| Albert A. Manzone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2024 | 8,764 | 0 | - | - | Restricted Stock Units | |
| Albert A. Manzone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.22 per share. | 14 May 2024 | 8,764 | 11,612 (0%) | 0% | 30.2 | 264,848 | Ordinary Shares |
| Albert A. Manzone | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 30.22 per share. | 14 May 2024 | 4,207 | 7,405 (0%) | 0% | 30.2 | 127,136 | Ordinary Shares |
| Albert A. Manzone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2024 | 9,904 | 9,904 | - | - | Restricted Stock Units | |
| Julia M. Brown | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2024 | 9,904 | 9,904 | - | - | Restricted Stock Units | |
| Kyle L. Hanson | EVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 12,420 | 12,420 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 6,640 | 6,640 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 6,210 | 6,210 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 8,121 | 8,121 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 13,376 | 13,376 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 6,210 | 6,210 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 7,166 | 7,166 | - | - | Restricted Stock Units | |
| Patrick Lockwood-Taylor | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2024 | 53,503 | 53,503 | - | - | Restricted Stock Units | |
| Kyle L. Hanson | EVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 3,518 | 7,034 | - | - | Restricted Stock Units | |
| Kyle L. Hanson | EVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.09 per share. | 06 Mar 2024 | 3,518 | 12,284 (0%) | 0% | 28.1 | 98,821 | Ordinary Shares |
| Kyle L. Hanson | EVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.09 per share. | 06 Mar 2024 | 1,147 | 11,137 (0%) | 0% | 28.1 | 32,219 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 1,881 | 3,760 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.09 per share. | 06 Mar 2024 | 1,881 | 11,389 (0%) | 0% | 28.1 | 52,837 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.09 per share. | 06 Mar 2024 | 696 | 10,693 (0%) | 0% | 28.1 | 19,551 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.09 per share. | 06 Mar 2024 | 1,759 | 20,914 (0%) | 0% | 28.1 | 49,410 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 2,249 | 2,249 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.69 per share. | 06 Mar 2024 | 1,170 | 21,078 (0%) | 0% | 29.7 | 34,737 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 1,759 | 3,517 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.69 per share. | 06 Mar 2024 | 2,249 | 22,248 (0%) | 0% | 29.7 | 66,773 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.09 per share. | 06 Mar 2024 | 915 | 19,999 (0%) | 0% | 28.1 | 25,702 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.09 per share. | 06 Mar 2024 | 693 | 31,497 (0%) | 0% | 28.1 | 19,466 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 2,942 | 2,941 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 2,300 | 4,599 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.69 per share. | 06 Mar 2024 | 886 | 33,553 (0%) | 0% | 29.7 | 26,305 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.69 per share. | 06 Mar 2024 | 2,942 | 34,439 (0%) | 0% | 29.7 | 87,348 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.09 per share. | 06 Mar 2024 | 2,300 | 32,190 (0%) | 0% | 28.1 | 64,607 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.69 per share. | 06 Mar 2024 | 5,468 | 100,853 (0%) | 0% | 29.7 | 162,345 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 5,468 | 5,468 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 3,788 | 7,576 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.09 per share. | 06 Mar 2024 | 3,788 | 95,385 (0%) | 0% | 28.1 | 106,405 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 1,759 | 3,517 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 2,163 | 2,163 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.09 per share. | 06 Mar 2024 | 1,759 | 31,347 (0%) | 0% | 28.1 | 49,410 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.09 per share. | 06 Mar 2024 | 915 | 30,432 (0%) | 0% | 28.1 | 25,702 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.69 per share. | 06 Mar 2024 | 2,163 | 32,595 (0%) | 0% | 29.7 | 64,219 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.69 per share. | 06 Mar 2024 | 1,125 | 31,470 (0%) | 0% | 29.7 | 33,401 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 29.69 per share. | 06 Mar 2024 | 526 | 18,010 (0%) | 0% | 29.7 | 15,617 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.09 per share. | 06 Mar 2024 | 2,030 | 17,402 (0%) | 0% | 28.1 | 57,023 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.09 per share. | 06 Mar 2024 | 612 | 16,790 (0%) | 0% | 28.1 | 17,191 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.69 per share. | 06 Mar 2024 | 1,746 | 18,536 (0%) | 0% | 29.7 | 51,839 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 2,030 | 4,058 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2024 | 1,746 | 1,746 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.26 per share. | 05 Mar 2024 | 627 | 3,889 (0%) | 0% | 27.3 | 17,092 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Grant, award, or other acquisition of securities at price $ 27.26 per share. | 05 Mar 2024 | 9,652 | 13,541 (0%) | 0% | 27.3 | 263,114 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.26 per share. | 05 Mar 2024 | 4,033 | 9,508 (0%) | 0% | 27.3 | 109,940 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2024 | 1,693 | 0 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.26 per share. | 05 Mar 2024 | 1,693 | 4,516 (0%) | 0% | 27.3 | 46,151 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 27.26 per share. | 05 Mar 2024 | 9,028 | 23,850 (0%) | 0% | 27.3 | 246,103 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.26 per share. | 05 Mar 2024 | 824 | 14,822 (0%) | 0% | 27.3 | 22,462 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.26 per share. | 05 Mar 2024 | 1,583 | 15,646 (0%) | 0% | 27.3 | 43,153 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2024 | 1,583 | 0 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.26 per share. | 05 Mar 2024 | 4,695 | 19,155 (0%) | 0% | 27.3 | 127,986 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.26 per share. | 05 Mar 2024 | 624 | 21,638 (0%) | 0% | 27.3 | 17,010 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2024 | 2,071 | 0 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.26 per share. | 05 Mar 2024 | 3,554 | 29,890 (0%) | 0% | 27.3 | 96,882 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.26 per share. | 05 Mar 2024 | 2,071 | 22,262 (0%) | 0% | 27.3 | 56,455 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Grant, award, or other acquisition of securities at price $ 27.26 per share. | 05 Mar 2024 | 11,806 | 33,444 (0%) | 0% | 27.3 | 321,832 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.26 per share. | 05 Mar 2024 | 3,411 | 72,152 (0%) | 0% | 27.3 | 92,984 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Grant, award, or other acquisition of securities at price $ 27.26 per share. | 05 Mar 2024 | 19,445 | 91,597 (0%) | 0% | 27.3 | 530,071 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.26 per share. | 05 Mar 2024 | 1,279 | 26,755 (0%) | 0% | 27.3 | 34,866 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.26 per share. | 05 Mar 2024 | 666 | 26,089 (0%) | 0% | 27.3 | 18,155 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Grant, award, or other acquisition of securities at price $ 27.26 per share. | 05 Mar 2024 | 7,291 | 33,380 (0%) | 0% | 27.3 | 198,753 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.26 per share. | 05 Mar 2024 | 3,792 | 29,588 (0%) | 0% | 27.3 | 103,370 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2024 | 1,279 | 0 | - | - | Restricted Stock Units | |
| Julia M. Brown | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 5,548 | 5,548 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2024 | 1,698 | 0 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.26 per share. | 05 Mar 2024 | 1,698 | 14,144 (0%) | 0% | 27.3 | 46,287 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.26 per share. | 05 Mar 2024 | 512 | 13,632 (0%) | 0% | 27.3 | 13,957 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 27.26 per share. | 05 Mar 2024 | 2,490 | 16,122 (0%) | 0% | 27.3 | 67,877 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.26 per share. | 05 Mar 2024 | 750 | 15,372 (0%) | 0% | 27.3 | 20,445 | Ordinary Shares |
| Willis Robert | EVP & CHRO | Purchase of securities on an exchange or from another person at price $ 25.87 per share. | 29 Feb 2024 | 6,000 | 25,105 (0%) | 0% | 25.9 | 155,220 | Ordinary Shares |
| Patrick Lockwood-Taylor | Director, CEO | Purchase of securities on an exchange or from another person at price $ 26.54 per share. | 29 Feb 2024 | 9,500 | 20,500 (0%) | 0% | 26.5 | 252,168 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Purchase of securities on an exchange or from another person at price $ 26.30 per share. | 29 Feb 2024 | 371 | 25,476 (0%) | 0% | 26.3 | 9,757 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 26.44 per share. | 29 Feb 2024 | 1,545 | 12,446 (0%) | 0% | 26.4 | 40,850 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Purchase of securities on an exchange or from another person at price $ 31.01 per share. | 24 Nov 2023 | 5,550 | 19,105 (0%) | 0% | 31.0 | 172,106 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 29.34 per share. | 16 Nov 2023 | 2,040 | 10,901 (0%) | 0% | 29.3 | 59,854 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 29.34 per share. | 16 Nov 2023 | 2,040 | 10,380 (0%) | 0% | 29.3 | 59,854 | Ordinary Shares |
| Patrick Lockwood-Taylor | Director, CEO | Purchase of securities on an exchange or from another person at price $ 28.99 per share. | 14 Nov 2023 | 11,000 | 11,000 (0%) | 0% | 29.0 | 318,868 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2023 | 738 | 0 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 30.46 per share. | 06 Oct 2023 | 217 | 8,861 (0%) | 0% | 30.5 | 6,610 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 30.46 per share. | 06 Oct 2023 | 738 | 9,078 (0%) | 0% | 30.5 | 22,479 | Ordinary Shares |
| Albert A. Manzone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.88 per share. | 15 Aug 2023 | 5,478 | 5,478 (0%) | 0% | 38.9 | 212,985 | Ordinary Shares |
| Albert A. Manzone | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2023 | 5,478 | 0 | - | - | Restricted Stock Units | |
| Albert A. Manzone | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.88 per share. | 15 Aug 2023 | 2,630 | 2,848 (0%) | 0% | 38.9 | 102,254 | Ordinary Shares |
| Patrick Lockwood-Taylor | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jul 2023 | 84,977 | 84,977 | - | - | Restricted Stock Units | |
| Kyle L. Hanson | EVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.63 per share. | 07 Jul 2023 | 9,732 | 9,732 (0%) | 0% | 32.6 | 317,555 | Ordinary Shares |
| Kyle L. Hanson | EVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.63 per share. | 07 Jul 2023 | 786 | 8,766 (0%) | 0% | 32.6 | 25,647 | Ordinary Shares |
| Kyle L. Hanson | EVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.63 per share. | 07 Jul 2023 | 2,677 | 9,552 (0%) | 0% | 32.6 | 87,351 | Ordinary Shares |
| Kyle L. Hanson | EVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.63 per share. | 07 Jul 2023 | 2,857 | 6,875 (0%) | 0% | 32.6 | 93,224 | Ordinary Shares |
| Kyle L. Hanson | EVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2023 | 2,677 | 5,352 | - | - | Restricted Stock Units | |
| Kyle L. Hanson | EVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2023 | 9,732 | 0 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.63 per share. | 07 Jul 2023 | 271 | 8,340 (0%) | 0% | 32.6 | 8,843 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.63 per share. | 07 Jul 2023 | 920 | 8,611 (0%) | 0% | 32.6 | 30,020 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2023 | 920 | 1,839 | - | - | Restricted Stock Units | |
| Geoffrey M. Parker | Director | Purchase of securities on an exchange or from another person at price $ 33.06 per share. | 13 Jun 2023 | 10,000 | 25,879 (0%) | 0% | 33.1 | 330,637 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Purchase of securities on an exchange or from another person at price $ 33.41 per share. | 23 May 2023 | 2,900 | 68,741 (0%) | 0% | 33.4 | 96,902 | Ordinary Shares |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.86 per share. | 17 May 2023 | 7,778 | 22,184 (0%) | 0% | 32.9 | 255,585 | Ordinary Shares |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2023 | 7,778 | 0 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.86 per share. | 17 May 2023 | 3,734 | 18,450 (0%) | 0% | 32.9 | 122,699 | Ordinary Shares |
| Orlando D. Ashford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2023 | 9,723 | 0 | - | - | Restricted Stock Units | |
| Orlando D. Ashford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.86 per share. | 17 May 2023 | 9,723 | 14,705 (0%) | 0% | 32.9 | 319,498 | Ordinary Shares |
| Orlando D. Ashford | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.86 per share. | 17 May 2023 | 4,668 | 10,037 (0%) | 0% | 32.9 | 153,390 | Ordinary Shares |
| Geoffrey M. Parker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2023 | 7,778 | 0 | - | - | Restricted Stock Units | |
| Geoffrey M. Parker | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.86 per share. | 17 May 2023 | 3,734 | 15,705 (0%) | 0% | 32.9 | 122,699 | Ordinary Shares |
| Geoffrey M. Parker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.86 per share. | 17 May 2023 | 7,778 | 19,439 (0%) | 0% | 32.9 | 255,585 | Ordinary Shares |
| Bradley A. Alford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2023 | 7,778 | 0 | - | - | Restricted Stock Units | |
| Bradley A. Alford | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.86 per share. | 17 May 2023 | 3,734 | 31,453 (0%) | 0% | 32.9 | 122,699 | Ordinary Shares |
| Bradley A. Alford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.86 per share. | 17 May 2023 | 7,778 | 35,187 (0%) | 0% | 32.9 | 255,585 | Ordinary Shares |
| Donal O'Connor | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2023 | 7,778 | 0 | - | - | Restricted Stock Units | |
| Donal O'Connor | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.86 per share. | 17 May 2023 | 7,778 | 24,664 (0%) | 0% | 32.9 | 255,585 | Ordinary Shares |
| Donal O'Connor | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.86 per share. | 17 May 2023 | 3,734 | 20,930 (0%) | 0% | 32.9 | 122,699 | Ordinary Shares |
| Katherine C. Doyle | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2023 | 7,778 | 0 | - | - | Restricted Stock Units | |
| Katherine C. Doyle | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.86 per share. | 17 May 2023 | 3,734 | 10,406 (0%) | 0% | 32.9 | 122,699 | Ordinary Shares |
| Katherine C. Doyle | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.86 per share. | 17 May 2023 | 7,778 | 14,140 (0%) | 0% | 32.9 | 255,585 | Ordinary Shares |
| Adriana Karaboutis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.86 per share. | 17 May 2023 | 7,778 | 21,656 (0%) | 0% | 32.9 | 255,585 | Ordinary Shares |
| Adriana Karaboutis | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.86 per share. | 17 May 2023 | 3,734 | 17,922 (0%) | 0% | 32.9 | 122,699 | Ordinary Shares |
| Adriana Karaboutis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2023 | 7,778 | 0 | - | - | Restricted Stock Units | |
| Erica L. Mann | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2023 | 7,778 | 0 | - | - | Restricted Stock Units | |
| Erica L. Mann | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 32.86 per share. | 17 May 2023 | 3,734 | 12,901 (0%) | 0% | 32.9 | 122,699 | Ordinary Shares |
| Erica L. Mann | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.86 per share. | 17 May 2023 | 7,778 | 16,635 (0%) | 0% | 32.9 | 255,585 | Ordinary Shares |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2023 | 8,764 | 8,764 | - | - | Restricted Stock Units | |
| Orlando D. Ashford | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2023 | 10,955 | 10,955 | - | - | Restricted Stock Units | |
| Geoffrey M. Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2023 | 8,764 | 8,764 | - | - | Restricted Stock Units | |
| Bradley A. Alford | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2023 | 8,764 | 8,764 | - | - | Restricted Stock Units | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2023 | 8,764 | 8,764 | - | - | Restricted Stock Units | |
| Katherine C. Doyle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2023 | 8,764 | 8,764 | - | - | Restricted Stock Units | |
| Adriana Karaboutis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2023 | 8,764 | 8,764 | - | - | Restricted Stock Units | |
| Erica L. Mann | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2023 | 8,764 | 8,764 | - | - | Restricted Stock Units | |
| Albert A. Manzone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2023 | 8,764 | 8,764 | - | - | Restricted Stock Units | |
| Murray S. Kessler | Director, CEO | Sale of securities on an exchange or to another person at price $ 35.75 per share. | 11 May 2023 | 197,646 | 2,668 (0%) | 0% | 35.8 | 7,066,358 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Sale of securities on an exchange or to another person at price $ 35.57 per share. | 13 Mar 2023 | 3,523 | 3,023 (0%) | 0% | 35.6 | 125,317 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Sale of securities on an exchange or to another person at price $ 35.59 per share. | 13 Mar 2023 | 200 | 2,823 (0%) | 0% | 35.6 | 7,118 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Sale of securities on an exchange or to another person at price $ 35.70 per share. | 10 Mar 2023 | 9,000 | 25,130 (0%) | 0% | 35.7 | 321,309 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Sale of securities on an exchange or to another person at price $ 36.92 per share. | 08 Mar 2023 | 4,500 | 20,191 (0%) | 0% | 36.9 | 166,133 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.71 per share. | 07 Mar 2023 | 510 | 7,691 (0%) | 0% | 37.7 | 19,232 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2023 | 1,746 | 3,492 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.71 per share. | 07 Mar 2023 | 1,746 | 8,201 (0%) | 0% | 37.7 | 65,842 | Ordinary Shares |
| Kyle L. Hanson | EVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 10,552 | 10,552 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.71 per share. | 06 Mar 2023 | 1,159 | 6,546 (0%) | 0% | 37.7 | 43,706 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 5,641 | 5,641 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 2,406 | 4,810 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.71 per share. | 06 Mar 2023 | 2,406 | 7,705 (0%) | 0% | 37.7 | 90,730 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 26,994 | 53,986 | - | - | Restricted Stock Units | |
| Murray S. Kessler | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.71 per share. | 06 Mar 2023 | 11,850 | 200,314 (0%) | 0% | 37.7 | 446,864 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 79,140 | 79,140 | - | - | Restricted Stock Units | |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.71 per share. | 06 Mar 2023 | 26,994 | 212,164 (0%) | 0% | 37.7 | 1,017,944 | Ordinary Shares |
| Geoffrey M. Parker | Director | Purchase of securities on an exchange or from another person at price $ 38.05 per share. | 06 Mar 2023 | 5,000 | 15,879 (0%) | 0% | 38.1 | 190,270 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.71 per share. | 06 Mar 2023 | 2,250 | 15,233 (0%) | 0% | 37.7 | 84,848 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.71 per share. | 06 Mar 2023 | 1,170 | 14,063 (0%) | 0% | 37.7 | 44,121 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 2,250 | 4,498 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 5,276 | 5,276 | - | - | Restricted Stock Units | |
| James E. Dillard | EVP & President CSCA | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.71 per share. | 06 Mar 2023 | 2,498 | 34,130 (0%) | 0% | 37.7 | 94,200 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.71 per share. | 06 Mar 2023 | 5,537 | 36,628 (0%) | 0% | 37.7 | 208,800 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 12,175 | 12,175 | - | - | Restricted Stock Units | |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 5,537 | 11,074 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 6,899 | 6,899 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 2,942 | 5,883 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.71 per share. | 06 Mar 2023 | 1,099 | 24,691 (0%) | 0% | 37.7 | 41,443 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.71 per share. | 06 Mar 2023 | 2,942 | 25,790 (0%) | 0% | 37.7 | 110,943 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 11,364 | 11,364 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 5,468 | 10,936 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.71 per share. | 06 Mar 2023 | 5,468 | 65,841 (0%) | 0% | 37.7 | 206,198 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.71 per share. | 06 Mar 2023 | 2,163 | 14,680 (0%) | 0% | 37.7 | 81,567 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2023 | 2,163 | 4,326 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.71 per share. | 06 Mar 2023 | 1,125 | 13,555 (0%) | 0% | 37.7 | 42,424 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 5,276 | 5,276 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2023 | 6,088 | 6,088 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 1,261 | 0 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 1,693 | 5,998 (0%) | 0% | 38.8 | 65,604 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 521 | 4,305 (0%) | 0% | 38.8 | 20,189 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 1,261 | 4,826 (0%) | 0% | 38.8 | 48,864 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 2,928 | 3,565 (0%) | 0% | 38.8 | 113,460 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Grant, award, or other acquisition of securities at price $ 38.75 per share. | 03 Mar 2023 | 6,493 | 6,493 (0%) | 0% | 38.8 | 251,604 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 1,693 | 1,693 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 699 | 5,299 (0%) | 0% | 38.7 | 27,086 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 14,060 | 0 | - | - | Restricted Stock Units | |
| Murray S. Kessler | Director, CEO | Grant, award, or other acquisition of securities at price $ 38.75 per share. | 03 Mar 2023 | 72,410 | 192,911 (0%) | 0% | 38.8 | 2,805,888 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 28,494 | 164,417 (0%) | 0% | 38.8 | 1,104,143 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 14,060 | 178,477 (0%) | 0% | 38.8 | 544,825 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 5,203 | 173,274 (0%) | 0% | 38.7 | 201,616 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 18,884 | 192,158 (0%) | 0% | 38.8 | 731,755 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 6,988 | 185,170 (0%) | 0% | 38.8 | 270,785 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 18,884 | 18,884 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 38.75 per share. | 03 Mar 2023 | 5,419 | 14,537 (0%) | 0% | 38.7 | 209,986 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 1,584 | 1,583 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 1,052 | 0 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 824 | 12,983 (0%) | 0% | 38.8 | 31,930 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 1,584 | 13,807 (0%) | 0% | 38.8 | 61,380 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 548 | 12,223 (0%) | 0% | 38.8 | 21,235 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 1,052 | 12,771 (0%) | 0% | 38.8 | 40,765 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 2,818 | 11,719 (0%) | 0% | 38.8 | 109,198 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 2,680 | 32,300 (0%) | 0% | 38.8 | 103,850 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 900 | 29,620 (0%) | 0% | 38.8 | 34,875 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 1,995 | 30,520 (0%) | 0% | 38.7 | 77,306 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 4,690 | 28,525 (0%) | 0% | 38.8 | 181,738 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Grant, award, or other acquisition of securities at price $ 38.75 per share. | 03 Mar 2023 | 10,277 | 33,215 (0%) | 0% | 38.8 | 398,234 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 2,680 | 2,680 | - | - | Restricted Stock Units | |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 1,995 | 0 | - | - | Restricted Stock Units | |
| James E. Dillard | EVP & President CSCA | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 1,209 | 31,091 (0%) | 0% | 38.8 | 46,849 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 774 | 22,848 (0%) | 0% | 38.8 | 29,993 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Grant, award, or other acquisition of securities at price $ 38.75 per share. | 03 Mar 2023 | 7,941 | 23,627 (0%) | 0% | 38.8 | 307,714 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 3,042 | 20,585 (0%) | 0% | 38.8 | 117,878 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 1,542 | 22,127 (0%) | 0% | 38.8 | 59,753 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 576 | 21,551 (0%) | 0% | 38.8 | 22,320 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 2,071 | 23,622 (0%) | 0% | 38.7 | 80,251 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 2,071 | 2,071 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 1,542 | 0 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 2,540 | 0 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Grant, award, or other acquisition of securities at price $ 38.75 per share. | 03 Mar 2023 | 13,081 | 54,422 (0%) | 0% | 38.8 | 506,889 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 2,540 | 56,962 (0%) | 0% | 38.8 | 98,425 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 3,411 | 60,373 (0%) | 0% | 38.7 | 132,176 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 3,411 | 3,411 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 666 | 12,517 (0%) | 0% | 38.8 | 25,808 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 952 | 0 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 1,279 | 1,279 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Grant, award, or other acquisition of securities at price $ 38.75 per share. | 03 Mar 2023 | 4,905 | 13,999 (0%) | 0% | 38.8 | 190,069 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 2,551 | 11,448 (0%) | 0% | 38.7 | 98,851 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 952 | 12,400 (0%) | 0% | 38.8 | 36,890 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 496 | 11,904 (0%) | 0% | 38.8 | 19,220 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 1,279 | 13,183 (0%) | 0% | 38.7 | 49,561 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 510 | 0 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 1,698 | 7,090 (0%) | 0% | 38.8 | 65,798 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 237 | 5,392 (0%) | 0% | 38.8 | 9,184 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.75 per share. | 03 Mar 2023 | 510 | 5,629 (0%) | 0% | 38.8 | 19,763 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 314 | 5,119 (0%) | 0% | 38.8 | 12,168 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 38.75 per share. | 03 Mar 2023 | 677 | 5,433 (0%) | 0% | 38.8 | 26,234 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2023 | 1,698 | 1,698 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.75 per share. | 03 Mar 2023 | 635 | 6,455 (0%) | 0% | 38.7 | 24,606 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 31.65 per share. | 16 Dec 2022 | 2,368 | 9,118 (0%) | 0% | 31.6 | 74,947 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Oct 2022 | 739 | 738 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.09 per share. | 07 Oct 2022 | 739 | 4,973 (0%) | 0% | 38.1 | 28,149 | Ordinary Shares |
| Alison Ives | EVP & Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.09 per share. | 07 Oct 2022 | 217 | 4,756 (0%) | 0% | 38.1 | 8,266 | Ordinary Shares |
| Albert A. Manzone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2022 | 5,478 | 5,478 | - | - | Restricted Stock Units | |
| Alison Ives | EVP & Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jul 2022 | 2,759 | 2,759 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2022 | 6,599 | 0 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.57 per share. | 17 May 2022 | 3,168 | 14,406 (0%) | 0% | 38.6 | 122,190 | Ordinary Shares |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 7,778 | 7,778 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.57 per share. | 17 May 2022 | 6,599 | 17,574 (0%) | 0% | 38.6 | 254,523 | Ordinary Shares |
| Orlando D. Ashford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2022 | 6,599 | 0 | - | - | Restricted Stock Units | |
| Orlando D. Ashford | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.57 per share. | 17 May 2022 | 3,168 | 4,982 (0%) | 0% | 38.6 | 122,190 | Ordinary Shares |
| Orlando D. Ashford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.57 per share. | 17 May 2022 | 6,599 | 8,150 (0%) | 0% | 38.6 | 254,523 | Ordinary Shares |
| Orlando D. Ashford | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 9,723 | 9,723 | - | - | Restricted Stock Units | |
| Geoffrey M. Parker | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.57 per share. | 17 May 2022 | 3,168 | 11,661 (0%) | 0% | 38.6 | 122,190 | Ordinary Shares |
| Geoffrey M. Parker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.57 per share. | 17 May 2022 | 6,599 | 14,829 (0%) | 0% | 38.6 | 254,523 | Ordinary Shares |
| Geoffrey M. Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 7,778 | 7,778 | - | - | Restricted Stock Units | |
| Geoffrey M. Parker | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2022 | 6,599 | 0 | - | - | Restricted Stock Units | |
| Bradley A. Alford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.57 per share. | 17 May 2022 | 6,599 | 30,577 (0%) | 0% | 38.6 | 254,523 | Ordinary Shares |
| Bradley A. Alford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2022 | 6,599 | 0 | - | - | Restricted Stock Units | |
| Bradley A. Alford | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 7,778 | 7,778 | - | - | Restricted Stock Units | |
| Bradley A. Alford | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.57 per share. | 17 May 2022 | 3,168 | 27,409 (0%) | 0% | 38.6 | 122,190 | Ordinary Shares |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 7,778 | 7,778 | - | - | Restricted Stock Units | |
| Donal O'Connor | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2022 | 6,599 | 0 | - | - | Restricted Stock Units | |
| Donal O'Connor | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.57 per share. | 17 May 2022 | 3,168 | 16,886 (0%) | 0% | 38.6 | 122,190 | Ordinary Shares |
| Donal O'Connor | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.57 per share. | 17 May 2022 | 6,599 | 20,054 (0%) | 0% | 38.6 | 254,523 | Ordinary Shares |
| Katherine C. Doyle | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.57 per share. | 17 May 2022 | 6,599 | 9,530 (0%) | 0% | 38.6 | 254,523 | Ordinary Shares |
| Katherine C. Doyle | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2022 | 6,599 | 0 | - | - | Restricted Stock Units | |
| Katherine C. Doyle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 7,778 | 7,778 | - | - | Restricted Stock Units | |
| Katherine C. Doyle | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.57 per share. | 17 May 2022 | 3,168 | 6,362 (0%) | 0% | 38.6 | 122,190 | Ordinary Shares |
| Adriana Karaboutis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.57 per share. | 17 May 2022 | 6,599 | 17,046 (0%) | 0% | 38.6 | 254,523 | Ordinary Shares |
| Adriana Karaboutis | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2022 | 6,599 | 0 | - | - | Restricted Stock Units | |
| Adriana Karaboutis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 7,778 | 7,778 | - | - | Restricted Stock Units | |
| Adriana Karaboutis | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.57 per share. | 17 May 2022 | 3,168 | 13,878 (0%) | 0% | 38.6 | 122,190 | Ordinary Shares |
| Erica L. Mann | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.57 per share. | 17 May 2022 | 6,599 | 12,289 (0%) | 0% | 38.6 | 254,523 | Ordinary Shares |
| Erica L. Mann | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2022 | 6,599 | 0 | - | - | Restricted Stock Units | |
| Erica L. Mann | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 7,778 | 7,778 | - | - | Restricted Stock Units | |
| Erica L. Mann | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.57 per share. | 17 May 2022 | 3,432 | 8,857 (0%) | 0% | 38.6 | 132,372 | Ordinary Shares |
| Theodore R. Samuels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.57 per share. | 17 May 2022 | 6,599 | 26,693 (0%) | 0% | 38.6 | 254,523 | Ordinary Shares |
| Theodore R. Samuels | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2022 | 6,599 | 0 | - | - | Restricted Stock Units | |
| Theodore R. Samuels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 7,778 | 7,778 | - | - | Restricted Stock Units | |
| Raymond P. Silcock | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2022 | 3,963 | 0 | - | - | Restricted Stock Units | |
| Raymond P. Silcock | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.27 per share. | 05 Apr 2022 | 3,963 | 60,955 (0%) | 0% | 36.3 | 143,738 | Ordinary Shares |
| Raymond P. Silcock | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 36.27 per share. | 05 Apr 2022 | 1,467 | 59,488 (0%) | 0% | 36.3 | 53,208 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Sale of securities on an exchange or to another person at price $ 37.23 per share. | 14 Mar 2022 | 2,259 | 0 (0%) | 0% | 37.2 | 84,103 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Sale of securities on an exchange or to another person at price $ 37.13 per share. | 14 Mar 2022 | 24,485 | 0 (0%) | 0% | 37.1 | 909,079 | Ordinary Shares |
| Todd W. Kingma | Executive VP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 2,959 | 42,994 (0%) | 0% | 37.2 | 110,164 | Ordinary Shares |
| Todd W. Kingma | Executive VP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 6,324 | 40,035 (0%) | 0% | 37.2 | 235,443 | Ordinary Shares |
| Todd W. Kingma | Executive VP, General Counsel | Grant, award, or other acquisition of securities at price $ 37.23 per share. | 04 Mar 2022 | 14,503 | 46,359 (0%) | 0% | 37.2 | 539,947 | Ordinary Shares |
| Todd W. Kingma | Executive VP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 11,628 | 11,628 | - | - | Restricted Stock Units | |
| Todd W. Kingma | Executive VP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 3,412 | 6,822 | - | - | Restricted Stock Units | |
| Todd W. Kingma | Executive VP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 3,412 | 46,677 (0%) | 0% | 37.2 | 127,029 | Ordinary Shares |
| Todd W. Kingma | Executive VP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 1,408 | 45,269 (0%) | 0% | 37.2 | 52,420 | Ordinary Shares |
| Todd W. Kingma | Executive VP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 2,959 | 0 | - | - | Restricted Stock Units | |
| Todd W. Kingma | Executive VP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 2,540 | 2,540 | - | - | Restricted Stock Units | |
| Todd W. Kingma | Executive VP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 1,048 | 43,265 (0%) | 0% | 37.2 | 39,017 | Ordinary Shares |
| Todd W. Kingma | Executive VP, General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 2,540 | 44,313 (0%) | 0% | 37.2 | 94,564 | Ordinary Shares |
| Todd W. Kingma | Executive VP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 1,221 | 41,773 (0%) | 0% | 37.2 | 45,458 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Grant, award, or other acquisition of securities at price $ 37.23 per share. | 04 Mar 2022 | 7,200 | 25,028 (0%) | 0% | 37.2 | 268,056 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 521 | 23,491 (0%) | 0% | 37.2 | 19,397 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 1,261 | 1,261 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 1,694 | 25,185 (0%) | 0% | 37.2 | 63,068 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 699 | 24,486 (0%) | 0% | 37.2 | 26,024 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 1,469 | 0 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 7,216 | 7,216 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 1,694 | 3,386 | - | - | Restricted Stock Units | |
| Thomas M. Farrington | EVP and CIO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 3,140 | 21,888 (0%) | 0% | 37.2 | 116,902 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 1,469 | 23,357 (0%) | 0% | 37.2 | 54,691 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 606 | 22,751 (0%) | 0% | 37.2 | 22,561 | Ordinary Shares |
| Thomas M. Farrington | EVP and CIO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 1,261 | 24,012 (0%) | 0% | 37.2 | 46,947 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 14,060 | 113,808 (0%) | 0% | 37.2 | 523,454 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Grant, award, or other acquisition of securities at price $ 37.23 per share. | 04 Mar 2022 | 80,286 | 123,768 (0%) | 0% | 37.2 | 2,989,048 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 34,341 | 89,427 (0%) | 0% | 37.2 | 1,278,515 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 16,384 | 105,811 (0%) | 0% | 37.2 | 609,976 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 6,063 | 99,748 (0%) | 0% | 37.2 | 225,725 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 80,980 | 80,980 | - | - | Restricted Stock Units | |
| Murray S. Kessler | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 6,988 | 120,501 (0%) | 0% | 37.2 | 260,163 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 16,384 | 0 | - | - | Restricted Stock Units | |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 14,060 | 14,060 | - | - | Restricted Stock Units | |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 18,884 | 37,768 | - | - | Restricted Stock Units | |
| Murray S. Kessler | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 18,884 | 127,489 (0%) | 0% | 37.2 | 703,051 | Ordinary Shares |
| Murray S. Kessler | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 5,203 | 108,605 (0%) | 0% | 37.2 | 193,708 | Ordinary Shares |
| Raymond P. Silcock | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 1,804 | 56,992 (0%) | 0% | 37.2 | 67,163 | Ordinary Shares |
| Raymond P. Silcock | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 37.23 per share. | 04 Mar 2022 | 19,422 | 57,118 (0%) | 0% | 37.2 | 723,081 | Ordinary Shares |
| Raymond P. Silcock | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 5,481 | 51,637 (0%) | 0% | 37.2 | 204,058 | Ordinary Shares |
| Raymond P. Silcock | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 3,628 | 55,265 (0%) | 0% | 37.2 | 135,070 | Ordinary Shares |
| Raymond P. Silcock | EVP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 1,343 | 53,922 (0%) | 0% | 37.2 | 50,000 | Ordinary Shares |
| Raymond P. Silcock | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 4,874 | 9,746 | - | - | Restricted Stock Units | |
| Raymond P. Silcock | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 20,764 | 20,764 | - | - | Restricted Stock Units | |
| Raymond P. Silcock | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 4,874 | 58,796 (0%) | 0% | 37.2 | 181,459 | Ordinary Shares |
| Raymond P. Silcock | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 3,628 | 3,628 | - | - | Restricted Stock Units | |
| Orlando D. Ashford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 2,984 | 2,984 (0%) | 0% | 37.2 | 111,094 | Ordinary Shares |
| Orlando D. Ashford | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 1,433 | 1,551 (0%) | 0% | 37.2 | 53,351 | Ordinary Shares |
| Orlando D. Ashford | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 2,984 | 0 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 638 | 10,222 (0%) | 0% | 37.2 | 23,753 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 37.23 per share. | 04 Mar 2022 | 6,008 | 12,759 (0%) | 0% | 37.2 | 223,678 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 3,125 | 9,634 (0%) | 0% | 37.2 | 116,344 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 1,226 | 10,860 (0%) | 0% | 37.2 | 45,644 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 1,052 | 11,274 (0%) | 0% | 37.2 | 39,166 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 548 | 10,726 (0%) | 0% | 37.2 | 20,402 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 1,584 | 12,310 (0%) | 0% | 37.2 | 58,972 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 824 | 11,486 (0%) | 0% | 37.2 | 30,678 | Ordinary Shares |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 1,226 | 0 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 1,052 | 1,052 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 1,584 | 3,167 | - | - | Restricted Stock Units | |
| Grainne Quinn | EVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 6,748 | 6,748 | - | - | Restricted Stock Units | |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 2,681 | 5,360 | - | - | Restricted Stock Units | |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 1,996 | 1,995 | - | - | Restricted Stock Units | |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 2,325 | 0 | - | - | Restricted Stock Units | |
| James E. Dillard | EVP & President CSCA | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 1,210 | 22,938 (0%) | 0% | 37.2 | 45,048 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 2,681 | 24,148 (0%) | 0% | 37.2 | 99,814 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 901 | 21,467 (0%) | 0% | 37.2 | 33,544 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 1,996 | 22,368 (0%) | 0% | 37.2 | 74,311 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 1,049 | 20,372 (0%) | 0% | 37.2 | 39,054 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 2,325 | 21,421 (0%) | 0% | 37.2 | 86,560 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 5,140 | 19,096 (0%) | 0% | 37.2 | 191,362 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Grant, award, or other acquisition of securities at price $ 37.23 per share. | 04 Mar 2022 | 11,395 | 24,236 (0%) | 0% | 37.2 | 424,236 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 16,611 | 16,611 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 8,825 | 8,825 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 3,906 | 16,630 (0%) | 0% | 37.2 | 145,420 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Grant, award, or other acquisition of securities at price $ 37.23 per share. | 04 Mar 2022 | 8,805 | 20,536 (0%) | 0% | 37.2 | 327,810 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 1,797 | 18,427 (0%) | 0% | 37.2 | 66,902 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 797 | 17,630 (0%) | 0% | 37.2 | 29,672 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 1,542 | 19,172 (0%) | 0% | 37.2 | 57,409 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 684 | 18,488 (0%) | 0% | 37.2 | 25,465 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 2,071 | 20,559 (0%) | 0% | 37.2 | 77,103 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 919 | 19,640 (0%) | 0% | 37.2 | 34,214 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Sale of securities on an exchange or to another person at price $ 36.73 per share. | 04 Mar 2022 | 3,954 | 15,686 (0%) | 0% | 36.7 | 145,232 | Ordinary Shares |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 1,797 | 0 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 1,542 | 1,542 | - | - | Restricted Stock Units | |
| Ronald Craig Janish | EVP, Gbl Ops & SC & CTO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 2,071 | 4,142 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 196 | 37,960 (0%) | 0% | 37.2 | 7,297 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 2,540 | 2,540 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 3,412 | 6,822 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 16,404 | 16,404 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 31 | 41,341 (0%) | 0% | 37.2 | 1,154 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 3,412 | 41,372 (0%) | 0% | 37.2 | 127,029 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 2,959 | 0 | - | - | Restricted Stock Units | |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 2,540 | 38,156 (0%) | 0% | 37.2 | 94,564 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 180 | 35,616 (0%) | 0% | 37.2 | 6,701 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 2,959 | 35,796 (0%) | 0% | 37.2 | 110,164 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 882 | 32,837 (0%) | 0% | 37.2 | 32,837 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Grant, award, or other acquisition of securities at price $ 37.23 per share. | 04 Mar 2022 | 14,503 | 33,719 (0%) | 0% | 37.2 | 539,947 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 286 | 6,954 (0%) | 0% | 37.2 | 10,648 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 550 | 7,240 (0%) | 0% | 37.2 | 20,477 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 1,122 | 6,690 (0%) | 0% | 37.2 | 41,772 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Grant, award, or other acquisition of securities at price $ 37.23 per share. | 04 Mar 2022 | 2,156 | 7,812 (0%) | 0% | 37.2 | 80,268 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 1,479 | 5,656 (0%) | 0% | 37.2 | 55,063 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Grant, award, or other acquisition of securities at price $ 37.23 per share. | 04 Mar 2022 | 2,843 | 7,135 (0%) | 0% | 37.2 | 105,845 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 1,650 | 8,604 (0%) | 0% | 37.2 | 61,430 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 858 | 7,746 (0%) | 0% | 37.2 | 31,943 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 580 | 8,326 (0%) | 0% | 37.2 | 21,593 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 302 | 8,024 (0%) | 0% | 37.2 | 11,243 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 952 | 8,976 (0%) | 0% | 37.2 | 35,443 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 496 | 8,480 (0%) | 0% | 37.2 | 18,466 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 37.23 per share. | 04 Mar 2022 | 1,280 | 9,760 (0%) | 0% | 37.2 | 47,654 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.23 per share. | 04 Mar 2022 | 666 | 9,094 (0%) | 0% | 37.2 | 24,795 | Ordinary Shares |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 550 | 0 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 1,650 | 0 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 580 | 0 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 952 | 952 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 1,280 | 2,558 | - | - | Restricted Stock Units | |
| Robert Willis | EVP & CHRO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 6,489 | 6,489 | - | - | Restricted Stock Units | |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 36.95 per share. | 07 Feb 2022 | 4,297 | 14,900 (0%) | 0% | 36.9 | 158,774 | Ordinary Shares |
| James E. Dillard | EVP & President CSCA | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Feb 2022 | 4,297 | 0 | - | - | Restricted Stock Units | |
| James E. Dillard | EVP & President CSCA | Payment of exercise price or tax liability using portion of securities received from the company at price $ 36.95 per share. | 07 Feb 2022 | 2,059 | 12,841 (0%) | 0% | 36.9 | 76,080 | Ordinary Shares |
| Todd W. Kingma | Executive VP, General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2021 | 10,000 | 20,000 (0%) | 0% | 0 | Ordinary Shares | |
| Todd W. Kingma | Executive VP, General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2021 | 10,000 | 41,856 (0%) | 0% | 0 | Ordinary Shares | |
| Todd W. Kingma | Executive VP, General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2021 | 10,000 | 10,000 (0%) | 0% | 0 | Ordinary Shares | |
| Todd W. Kingma | Executive VP, General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2021 | 10,000 | 31,856 (0%) | 0% | 0 | Ordinary Shares | |
| Todd W. Kingma | Executive VP, General Counsel | Purchase of securities on an exchange or from another person at price $ 37.55 per share. | 17 Dec 2021 | 3,000 | 51,856 (0%) | 0% | 37.5 | 112,648 | Ordinary Shares |
| Geoffrey M. Parker | Director | Purchase of securities on an exchange or from another person at price $ 36.85 per share. | 16 Dec 2021 | 5,000 | 10,879 (0%) | 0% | 36.9 | 184,270 | Ordinary Shares |
| Bradley A. Alford | Director | Purchase of securities on an exchange or from another person at price $ 36.88 per share. | 16 Dec 2021 | 13,000 | 23,978 (0%) | 0% | 36.9 | 479,409 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Purchase of securities on an exchange or from another person at price $ 37.08 per share. | 06 Dec 2021 | 1,255 | 13,683 (0%) | 0% | 37.1 | 46,535 | Ordinary Shares |
| Svend Andersen | EVP & President CHCI | Purchase of securities on an exchange or from another person at price $ 37.11 per share. | 06 Dec 2021 | 2,400 | 12,428 (0%) | 0% | 37.1 | 89,064 | Ordinary Shares |
| Raymond P. Silcock | EVP, Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 36.03 per share. | 03 Dec 2021 | 27,500 | 37,696 (0%) | 0% | 36.0 | 990,930 | Ordinary Shares |
| Rolf A. Classon | Director | Purchase of securities on an exchange or from another person at price $ 35.67 per share. | 02 Dec 2021 | 2,800 | 17,442 (0%) | 0% | 35.7 | 99,874 | Ordinary Shares |
| Katherine C. Doyle | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 41.28 per share. | 12 Aug 2021 | 2,706 | 2,931 (0%) | 0% | 41.3 | 111,704 | Ordinary Shares |
| Katherine C. Doyle | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 41.28 per share. | 12 Aug 2021 | 5,637 | 5,637 (0%) | 0% | 41.3 | 232,695 | Ordinary Shares |
| Katherine C. Doyle | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2021 | 5,637 | 0 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 6,599 | 6,599 | - | - | Restricted Stock Units | |
| Rolf A. Classon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 8,249 | 8,249 | - | - | Restricted Stock Units | |
| Orlando D. Ashford | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 6,599 | 6,599 | - | - | Restricted Stock Units | |
| Geoffrey M. Parker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 6,599 | 6,599 | - | - | Restricted Stock Units | |
| Bradley A. Alford | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 6,599 | 6,599 | - | - | Restricted Stock Units | |
| Donal O'Connor | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 6,599 | 6,599 | - | - | Restricted Stock Units | |
| Katherine C. Doyle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 6,599 | 6,599 | - | - | Restricted Stock Units | |
| Adriana Karaboutis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 6,599 | 6,599 | - | - | Restricted Stock Units | |
| Erica L. Mann | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 6,599 | 6,599 | - | - | Restricted Stock Units | |
| Theodore R. Samuels | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 6,599 | 6,599 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 May 2021 | 5,804 | 0 | - | - | Restricted Stock Units | |
| Jeffrey B. Kindler | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.96 per share. | 07 May 2021 | 5,804 | 13,761 (0%) | 0% | 43.0 | 249,340 | Ordinary Shares |
| Jeffrey B. Kindler | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 42.96 per share. | 07 May 2021 | 2,786 | 10,975 (0%) | 0% | 43.0 | 119,687 | Ordinary Shares |