XNAS 14 Jul, 2025 3:01 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 267.81 per share. | 24 Jun 2025 | 100 | 0 (0%) | 0% | 267.8 | 26,781 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 266.57 per share. | 24 Jun 2025 | 507 | 100 (0%) | 0% | 266.6 | 135,149 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 265.35 per share. | 24 Jun 2025 | 1,100 | 607 (0%) | 0% | 265.4 | 291,888 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 263.50 per share. | 24 Jun 2025 | 300 | 1,707 (0%) | 0% | 263.5 | 79,050 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 262.90 per share. | 23 Jun 2025 | 100 | 0 (0%) | 0% | 262.9 | 26,290 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 261.57 per share. | 23 Jun 2025 | 3,074 | 100 (0%) | 0% | 261.6 | 804,070 | American Depositary Shares |
| Xiaobin Wu | President and COO | Sale of securities on an exchange or to another person at price $ 260.00 per share. | 23 Jun 2025 | 1,363 | 0 (0%) | 0% | 260 | 354,380 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 260.00 per share. | 23 Jun 2025 | 1,028 | 0 (0%) | 0% | 260 | 267,280 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 256.49 per share. | 16 Jun 2025 | 1,460 | 0 (0%) | 0% | 256.5 | 374,473 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 266.05 per share. | 16 Jun 2025 | 3,680 | 1,460 (0%) | 0% | 266.0 | 979,046 | American Depositary Shares |
| Xiaobin Wu | President and COO | Sale of securities on an exchange or to another person at price $ 250.87 per share. | 16 Jun 2025 | 630 | 0 (0%) | 0% | 250.9 | 158,047 | American Depositary Shares |
| Xiaobin Wu | President and COO | Sale of securities on an exchange or to another person at price $ 266.22 per share. | 16 Jun 2025 | 100 | 630 (0%) | 0% | 266.2 | 26,622 | American Depositary Shares |
| Xiaobin Wu | President and COO | Sale of securities on an exchange or to another person at price $ 265.47 per share. | 16 Jun 2025 | 1,443 | 730 (0%) | 0% | 265.5 | 383,072 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 251.37 per share. | 16 Jun 2025 | 470 | 0 (0%) | 0% | 251.4 | 118,142 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 266.40 per share. | 16 Jun 2025 | 1,177 | 470 (0%) | 0% | 266.4 | 313,558 | American Depositary Shares |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 266.50 per share. | 16 Jun 2025 | 422 | 0 (0%) | 0% | 266.5 | 112,463 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 348,374 | 348,374 | - | - | Share Option (Right to Buy) | |
| John V. Oyler | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 185,055 | 8,281,841 (1%) | 0% | 0 | Ordinary Shares | |
| Qingqing Yi | Director | Other type of transaction at price $ 0.00 per share. | 10 Jun 2025 | 29,614 | 27,326 (0%) | 0% | 0 | Ordinary Shares | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 264.08 per share. | 10 Jun 2025 | 6,787 | 100 (0%) | 0% | 264.1 | 1,792,314 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 262.20 per share. | 10 Jun 2025 | 15,878 | 22,981 (0%) | 0% | 262.2 | 4,163,262 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 261.20 per share. | 10 Jun 2025 | 2,901 | 38,859 (0%) | 0% | 261.2 | 757,753 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 10 Jun 2025 | 41,760 | 41,760 (0%) | 0% | 6.5 | 271,440 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 98,696 | 5,180,861 (0%) | 0% | 0 | Ordinary Shares | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 542,880 | 7 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 185,796 | 185,796 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 264.85 per share. | 10 Jun 2025 | 100 | 0 (0%) | 0% | 264.9 | 26,485 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 263.17 per share. | 10 Jun 2025 | 16,094 | 6,887 (0%) | 0% | 263.2 | 4,235,501 | American Depositary Shares |
| Titus B. Ball | Principal Accounting Officer | Sale of securities on an exchange or to another person at price $ 258.36 per share. | 10 Jun 2025 | 134 | 0 (0%) | 0% | 258.4 | 34,620 | American Depositary Shares |
| Titus B. Ball | Principal Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 29,601 | 73,983 (0%) | 0% | 0 | Ordinary Shares | |
| Xiaobin Wu | President and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 232,245 | 232,245 | - | - | Share Option (Right to Buy) | |
| Xiaobin Wu | President and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 123,370 | 1,274,296 (0%) | 0% | 0 | Ordinary Shares | |
| Lai Wang | Global Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 162,565 | 162,565 | - | - | Share Option (Right to Buy) | |
| Lai Wang | Global Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 86,359 | 1,058,304 (0%) | 0% | 0 | Ordinary Shares | |
| Chan Henry Lee | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 88,244 | 88,244 | - | - | Share Option (Right to Buy) | |
| Chan Henry Lee | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 46,878 | 283,920 (0%) | 0% | 0 | Ordinary Shares | |
| Aaron Rosenberg | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 119,873 | 119,873 | - | - | Share Option (Right to Buy) | |
| Aaron Rosenberg | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2025 | 63,674 | 230,802 (0%) | 0% | 0 | Ordinary Shares | |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 255.74 per share. | 06 Jun 2025 | 400 | 0 (0%) | 0% | 255.7 | 102,295 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 254.97 per share. | 06 Jun 2025 | 927 | 400 (0%) | 0% | 255.0 | 236,358 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 253.49 per share. | 06 Jun 2025 | 1,000 | 1,327 (0%) | 0% | 253.5 | 253,490 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 251.88 per share. | 06 Jun 2025 | 1,400 | 2,327 (0%) | 0% | 251.9 | 352,626 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 250.84 per share. | 06 Jun 2025 | 1,400 | 3,727 (0%) | 0% | 250.8 | 351,177 | American Depositary Shares |
| Xiaobin Wu | President and COO | Sale of securities on an exchange or to another person at price $ 255.77 per share. | 06 Jun 2025 | 234 | 0 (0%) | 0% | 255.8 | 59,850 | American Depositary Shares |
| Xiaobin Wu | President and COO | Sale of securities on an exchange or to another person at price $ 255.30 per share. | 06 Jun 2025 | 400 | 234 (0%) | 0% | 255.3 | 102,122 | American Depositary Shares |
| Xiaobin Wu | President and COO | Sale of securities on an exchange or to another person at price $ 253.50 per share. | 06 Jun 2025 | 400 | 634 (0%) | 0% | 253.5 | 101,399 | American Depositary Shares |
| Xiaobin Wu | President and COO | Sale of securities on an exchange or to another person at price $ 251.85 per share. | 06 Jun 2025 | 500 | 1,034 (0%) | 0% | 251.9 | 125,926 | American Depositary Shares |
| Xiaobin Wu | President and COO | Sale of securities on an exchange or to another person at price $ 250.74 per share. | 06 Jun 2025 | 400 | 1,534 (0%) | 0% | 250.7 | 100,294 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 253.19 per share. | 06 Jun 2025 | 300 | 300 (0%) | 0% | 253.2 | 75,956 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 250.71 per share. | 06 Jun 2025 | 600 | 802 (0%) | 0% | 250.7 | 150,425 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 251.89 per share. | 06 Jun 2025 | 202 | 600 (0%) | 0% | 251.9 | 50,882 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 255.30 per share. | 06 Jun 2025 | 300 | 0 (0%) | 0% | 255.3 | 76,590 | American Depositary Shares |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 255.78 per share. | 06 Jun 2025 | 470 | 230 (0%) | 0% | 255.8 | 120,217 | American Depositary Shares |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 256.80 per share. | 06 Jun 2025 | 230 | 0 (0%) | 0% | 256.8 | 59,063 | American Depositary Shares |
| Anthony C. Hooper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 10,985 | 64,740 (0%) | 0% | 0 | Ordinary Shares | |
| Anthony C. Hooper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 22,750 | 22,750 | - | - | Share Option (Right to Buy) | |
| Shalini Sharp | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 10,985 | 19,136 (0%) | 0% | 0 | Ordinary Shares | |
| Shalini Sharp | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 22,750 | 22,750 | - | - | Share Option (Right to Buy) | |
| Olivier Raymond Brandicourt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 10,985 | 27,326 (0%) | 0% | 0 | Ordinary Shares | |
| Olivier Raymond Brandicourt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 22,750 | 22,750 | - | - | Share Option (Right to Buy) | |
| Qingqing Yi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 22,750 | 22,750 | - | - | Share Option (Right to Buy) | |
| Qingqing Yi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 10,985 | 56,940 (0%) | 0% | 0 | Ordinary Shares | |
| Corazon Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 22,750 | 22,750 | - | - | Share Option (Right to Buy) | |
| Corazon Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 10,985 | 57,226 (0%) | 0% | 0 | Ordinary Shares | |
| Alessandro Riva | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 22,750 | 22,750 | - | - | Share Option (Right to Buy) | |
| Alessandro Riva | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 10,985 | 56,940 (0%) | 0% | 0 | Ordinary Shares | |
| Margaret Dugan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 22,750 | 22,750 | - | - | Share Option (Right to Buy) | |
| Margaret Dugan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2025 | 10,985 | 56,940 (0%) | 0% | 0 | Ordinary Shares | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 222.83 per share. | 13 May 2025 | 10,221 | 31,539 (0%) | 0% | 222.8 | 2,277,501 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 223.41 per share. | 13 May 2025 | 21,235 | 10,304 (0%) | 0% | 223.4 | 4,744,092 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 224.32 per share. | 13 May 2025 | 10,104 | 200 (0%) | 0% | 224.3 | 2,266,542 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 225.68 per share. | 13 May 2025 | 200 | 0 (0%) | 0% | 225.7 | 45,136 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 May 2025 | 542,880 | 542,887 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 13 May 2025 | 41,760 | 41,760 (0%) | 0% | 6.5 | 271,440 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.85 per share. | 09 May 2025 | 1,990,603 | 8,163,437 (1%) | 0% | 17.9 | 35,532,264 | Ordinary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.50 per share. | 09 May 2025 | 4,055,415 | 10,154,040 (1%) | 0% | 0.5 | 2,027,708 | Ordinary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 May 2025 | 4,055,415 | 7 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Apr 2025 | 542,880 | 1,085,767 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 249.45 per share. | 14 Apr 2025 | 365 | 0 (0%) | 0% | 249.5 | 91,050 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 248.90 per share. | 14 Apr 2025 | 535 | 365 (0%) | 0% | 248.9 | 133,162 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 247.46 per share. | 14 Apr 2025 | 1,475 | 900 (0%) | 0% | 247.5 | 365,007 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 246.40 per share. | 14 Apr 2025 | 1,869 | 2,375 (0%) | 0% | 246.4 | 460,516 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 245.56 per share. | 14 Apr 2025 | 2,056 | 4,244 (0%) | 0% | 245.6 | 504,876 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 244.56 per share. | 14 Apr 2025 | 1,592 | 6,300 (0%) | 0% | 244.6 | 389,337 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 243.41 per share. | 14 Apr 2025 | 6,398 | 7,892 (0%) | 0% | 243.4 | 1,557,363 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 242.59 per share. | 14 Apr 2025 | 15,041 | 14,290 (0%) | 0% | 242.6 | 3,648,733 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 241.51 per share. | 14 Apr 2025 | 2,229 | 29,331 (0%) | 0% | 241.5 | 538,323 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 240.41 per share. | 14 Apr 2025 | 5,516 | 31,560 (0%) | 0% | 240.4 | 1,326,124 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 239.51 per share. | 14 Apr 2025 | 2,884 | 37,076 (0%) | 0% | 239.5 | 690,755 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 238.48 per share. | 14 Apr 2025 | 805 | 39,960 (0%) | 0% | 238.5 | 191,976 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 237.56 per share. | 14 Apr 2025 | 995 | 40,765 (0%) | 0% | 237.6 | 236,373 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 14 Apr 2025 | 41,760 | 41,760 (0%) | 0% | 6.5 | 271,440 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2025 | 214,201 | 0 | - | - | Share Option (Right to Buy) | |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 283.79 per share. | 01 Apr 2025 | 5,083 | 0 (0%) | 0% | 283.8 | 1,442,521 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 282.76 per share. | 01 Apr 2025 | 12,221 | 5,083 (0%) | 0% | 282.8 | 3,455,641 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 281.67 per share. | 01 Apr 2025 | 6,364 | 17,304 (0%) | 0% | 281.7 | 1,792,571 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 280.31 per share. | 01 Apr 2025 | 28,253 | 23,668 (0%) | 0% | 280.3 | 7,919,638 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 174.43 per share. | 01 Apr 2025 | 35,444 | 51,921 (0%) | 0% | 174.4 | 6,182,497 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 119.96 per share. | 01 Apr 2025 | 16,477 | 16,477 (0%) | 0% | 120.0 | 1,976,581 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2025 | 460,772 | 296,049 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Mar 2025 | 542,880 | 1,628,647 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 264.01 per share. | 18 Mar 2025 | 1,107 | 0 (0%) | 0% | 264.0 | 292,262 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 263.08 per share. | 18 Mar 2025 | 6,923 | 1,107 (0%) | 0% | 263.1 | 1,821,298 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 262.12 per share. | 18 Mar 2025 | 11,245 | 8,030 (0%) | 0% | 262.1 | 2,947,557 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 261.44 per share. | 18 Mar 2025 | 10,448 | 19,275 (0%) | 0% | 261.4 | 2,731,492 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 259.86 per share. | 18 Mar 2025 | 2,694 | 29,723 (0%) | 0% | 259.9 | 700,063 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 259.08 per share. | 18 Mar 2025 | 6,926 | 32,417 (0%) | 0% | 259.1 | 1,794,380 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 258.25 per share. | 18 Mar 2025 | 2,417 | 39,343 (0%) | 0% | 258.3 | 624,200 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 18 Mar 2025 | 41,760 | 41,760 (0%) | 0% | 6.5 | 271,440 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Gift of securities by or to the insider at price $ 0.00 per share. | 11 Mar 2025 | 158,717 | 5,082,165 (0%) | 0% | 0 | Ordinary Shares | |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.50 per share. | 10 Mar 2025 | 497,822 | 6,098,625 (0%) | 0% | 0.5 | 248,911 | Ordinary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 1,033,552 | 4,055,422 | - | - | Share Option (Right to Buy) | |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 246.85 per share. | 10 Mar 2025 | 700 | 0 (0%) | 0% | 246.8 | 172,793 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 246.11 per share. | 10 Mar 2025 | 4,913 | 700 (0%) | 0% | 246.1 | 1,209,128 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 245.19 per share. | 10 Mar 2025 | 3,006 | 5,613 (0%) | 0% | 245.2 | 737,028 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 244.04 per share. | 10 Mar 2025 | 5,313 | 8,619 (0%) | 0% | 244.0 | 1,296,584 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 243.04 per share. | 10 Mar 2025 | 9,309 | 13,932 (0%) | 0% | 243.0 | 2,262,455 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 241.92 per share. | 10 Mar 2025 | 7,069 | 23,241 (0%) | 0% | 241.9 | 1,710,157 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 240.70 per share. | 10 Mar 2025 | 2,200 | 30,310 (0%) | 0% | 240.7 | 529,533 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 239.59 per share. | 10 Mar 2025 | 6,800 | 32,510 (0%) | 0% | 239.6 | 1,629,200 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 238.74 per share. | 10 Mar 2025 | 1,900 | 39,310 (0%) | 0% | 238.7 | 453,605 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 10 Mar 2025 | 41,210 | 41,210 (0%) | 0% | 6.5 | 267,865 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.50 per share. | 07 Mar 2025 | 708,747 | 5,600,803 (0%) | 0% | 0.5 | 354,374 | Ordinary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 246.03 per share. | 07 Mar 2025 | 1,400 | 57,190 (0%) | 0% | 246.0 | 344,443 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 07 Mar 2025 | 58,590 | 58,590 (0%) | 0% | 6.5 | 380,835 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 246.69 per share. | 07 Mar 2025 | 1,190 | 53,900 (0%) | 0% | 246.7 | 293,567 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 246.91 per share. | 07 Mar 2025 | 13,918 | 39,982 (0%) | 0% | 246.9 | 3,436,548 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 247.99 per share. | 07 Mar 2025 | 7,600 | 32,382 (0%) | 0% | 248.0 | 1,884,710 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 249.04 per share. | 07 Mar 2025 | 8,905 | 23,477 (0%) | 0% | 249.0 | 2,217,708 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 249.97 per share. | 07 Mar 2025 | 12,578 | 10,899 (0%) | 0% | 250.0 | 3,144,087 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 251.00 per share. | 07 Mar 2025 | 2,300 | 8,599 (0%) | 0% | 251.0 | 577,304 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 252.24 per share. | 07 Mar 2025 | 3,299 | 5,300 (0%) | 0% | 252.2 | 832,127 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 253.21 per share. | 07 Mar 2025 | 1,100 | 4,200 (0%) | 0% | 253.2 | 278,526 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 254.10 per share. | 07 Mar 2025 | 1,300 | 2,900 (0%) | 0% | 254.1 | 330,326 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 255.02 per share. | 07 Mar 2025 | 2,400 | 500 (0%) | 0% | 255.0 | 612,053 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 256.10 per share. | 07 Mar 2025 | 500 | 0 (0%) | 0% | 256.1 | 128,050 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2025 | 1,470,417 | 5,088,974 | - | - | Share Option (Right to Buy) | |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 246.10 per share. | 07 Mar 2025 | 2,100 | 55,090 (0%) | 0% | 246.1 | 516,800 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 262.03 per share. | 05 Mar 2025 | 3,400 | 1,800 (0%) | 0% | 262.0 | 890,900 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2025 | 1,007,578 | 6,559,391 | - | - | Share Option (Right to Buy) | |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 264.27 per share. | 05 Mar 2025 | 100 | 0 (0%) | 0% | 264.3 | 26,427 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 262.97 per share. | 05 Mar 2025 | 1,700 | 100 (0%) | 0% | 263.0 | 447,047 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 261.08 per share. | 05 Mar 2025 | 2,906 | 5,200 (0%) | 0% | 261.1 | 758,697 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 259.77 per share. | 05 Mar 2025 | 6,705 | 8,106 (0%) | 0% | 259.8 | 1,741,786 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 258.91 per share. | 05 Mar 2025 | 8,200 | 14,811 (0%) | 0% | 258.9 | 2,123,073 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 257.92 per share. | 05 Mar 2025 | 13,598 | 23,011 (0%) | 0% | 257.9 | 3,507,199 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 256.91 per share. | 05 Mar 2025 | 3,500 | 36,609 (0%) | 0% | 256.9 | 899,200 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 05 Mar 2025 | 40,109 | 40,109 (0%) | 0% | 6.5 | 260,709 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.50 per share. | 05 Mar 2025 | 486,161 | 4,892,056 (0%) | 0% | 0.5 | 243,081 | Ordinary Shares |
| John V. Oyler | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 201,084 | 4,405,895 (0%) | 0% | 0 | Ordinary Shares | |
| Xiaobin Wu | President, COO & GM China | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 103,883 | 1,175,210 (0%) | 0% | 0 | Ordinary Shares | |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2025 | 583,349 | 214,201 | - | - | Share Option (Right to Buy) | |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2025 | 91,624 | 2 | - | - | Share Option (Right to Buy) | |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 263.00 per share. | 05 Mar 2025 | 200 | 0 (0%) | 0% | 263 | 52,600 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 262.51 per share. | 05 Mar 2025 | 22,537 | 200 (0%) | 0% | 262.5 | 5,916,235 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 261.61 per share. | 05 Mar 2025 | 11,360 | 22,737 (0%) | 0% | 261.6 | 2,971,882 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 260.39 per share. | 05 Mar 2025 | 17,824 | 34,097 (0%) | 0% | 260.4 | 4,641,188 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 119.96 per share. | 05 Mar 2025 | 44,873 | 51,921 (0%) | 0% | 120.0 | 5,382,965 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 169.65 per share. | 05 Mar 2025 | 7,048 | 7,048 (0%) | 0% | 169.6 | 1,195,693 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 69,251 | 990,171 (0%) | 0% | 0 | Ordinary Shares | |
| Chan Henry Lee | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 40,209 | 246,142 (0%) | 0% | 0 | Ordinary Shares | |
| Aaron Rosenberg | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 48,581 | 167,128 (0%) | 0% | 0 | Ordinary Shares | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 255.71 per share. | 04 Mar 2025 | 1,214 | 2,132 (0%) | 0% | 255.7 | 310,435 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 254.77 per share. | 04 Mar 2025 | 1,275 | 3,346 (0%) | 0% | 254.8 | 324,836 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 253.55 per share. | 04 Mar 2025 | 825 | 4,621 (0%) | 0% | 253.6 | 209,180 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 252.72 per share. | 04 Mar 2025 | 2,000 | 5,446 (0%) | 0% | 252.7 | 505,431 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 251.70 per share. | 04 Mar 2025 | 700 | 7,446 (0%) | 0% | 251.7 | 176,193 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 257.41 per share. | 04 Mar 2025 | 323 | 0 (0%) | 0% | 257.4 | 83,144 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 256.83 per share. | 04 Mar 2025 | 1,809 | 323 (0%) | 0% | 256.8 | 464,607 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.50 per share. | 03 Mar 2025 | 1,220,531 | 4,199,364 (0%) | 0% | 0.5 | 610,266 | Ordinary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2025 | 2,533,531 | 7,566,969 | - | - | Share Option (Right to Buy) | |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 249.25 per share. | 03 Mar 2025 | 600 | 0 (0%) | 0% | 249.2 | 149,549 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 248.63 per share. | 03 Mar 2025 | 3,900 | 600 (0%) | 0% | 248.6 | 969,671 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 247.63 per share. | 03 Mar 2025 | 6,480 | 4,500 (0%) | 0% | 247.6 | 1,604,611 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 246.57 per share. | 03 Mar 2025 | 7,243 | 10,980 (0%) | 0% | 246.6 | 1,785,905 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 245.51 per share. | 03 Mar 2025 | 19,232 | 18,223 (0%) | 0% | 245.5 | 4,721,706 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 245.36 per share. | 03 Mar 2025 | 1,090 | 37,455 (0%) | 0% | 245.4 | 267,437 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 244.56 per share. | 03 Mar 2025 | 18,386 | 38,545 (0%) | 0% | 244.6 | 4,496,442 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 244.45 per share. | 03 Mar 2025 | 4,910 | 56,931 (0%) | 0% | 244.5 | 1,200,272 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 243.44 per share. | 03 Mar 2025 | 11,195 | 61,841 (0%) | 0% | 243.4 | 2,725,326 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 242.46 per share. | 03 Mar 2025 | 8,192 | 73,036 (0%) | 0% | 242.5 | 1,986,233 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 241.38 per share. | 03 Mar 2025 | 13,816 | 81,228 (0%) | 0% | 241.4 | 3,334,881 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 240.53 per share. | 03 Mar 2025 | 5,956 | 95,044 (0%) | 0% | 240.5 | 1,432,605 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 03 Mar 2025 | 101,000 | 101,000 (0%) | 0% | 6.5 | 656,500 | American Depositary Shares |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 275.00 per share. | 27 Feb 2025 | 1,205 | 0 (0%) | 0% | 275 | 331,375 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 255.86 per share. | 21 Feb 2025 | 575 | 3,098 (0%) | 0% | 255.9 | 147,117 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 254.82 per share. | 21 Feb 2025 | 1,327 | 3,673 (0%) | 0% | 254.8 | 338,149 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 260.17 per share. | 21 Feb 2025 | 400 | 0 (0%) | 0% | 260.2 | 104,067 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 258.73 per share. | 21 Feb 2025 | 1,782 | 400 (0%) | 0% | 258.7 | 461,058 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 258.18 per share. | 21 Feb 2025 | 437 | 2,182 (0%) | 0% | 258.2 | 112,826 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 256.70 per share. | 21 Feb 2025 | 479 | 2,619 (0%) | 0% | 256.7 | 122,957 | American Depositary Shares |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 260.22 per share. | 21 Feb 2025 | 100 | 0 (0%) | 0% | 260.2 | 26,022 | American Depositary Shares |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 258.69 per share. | 21 Feb 2025 | 598 | 100 (0%) | 0% | 258.7 | 154,699 | American Depositary Shares |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 256.84 per share. | 21 Feb 2025 | 504 | 698 (0%) | 0% | 256.8 | 129,449 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 398,502 | 368,097 | - | - | Share Option (Right to Buy) | |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 240.07 per share. | 18 Feb 2025 | 21,267 | 0 (0%) | 0% | 240.1 | 5,105,513 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 169.65 per share. | 18 Feb 2025 | 21,267 | 21,267 (0%) | 0% | 169.7 | 3,607,947 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 242.08 per share. | 18 Feb 2025 | 3,159 | 0 (0%) | 0% | 242.1 | 764,729 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 241.26 per share. | 18 Feb 2025 | 7,919 | 3,159 (0%) | 0% | 241.3 | 1,910,559 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 240.31 per share. | 18 Feb 2025 | 19,576 | 11,078 (0%) | 0% | 240.3 | 4,704,244 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 169.65 per share. | 18 Feb 2025 | 30,654 | 30,654 (0%) | 0% | 169.6 | 5,200,451 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 276,471 | 91,626 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Feb 2025 | 542,880 | 2,171,527 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 04 Feb 2025 | 41,760 | 41,760 (0%) | 0% | 6.5 | 271,440 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 223.00 per share. | 04 Feb 2025 | 9,099 | 32,661 (0%) | 0% | 223.0 | 2,029,059 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 224.18 per share. | 04 Feb 2025 | 1,519 | 31,142 (0%) | 0% | 224.2 | 340,532 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 225.27 per share. | 04 Feb 2025 | 2,161 | 28,981 (0%) | 0% | 225.3 | 486,805 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 226.35 per share. | 04 Feb 2025 | 17,805 | 11,176 (0%) | 0% | 226.4 | 4,030,169 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 227.00 per share. | 04 Feb 2025 | 9,776 | 1,400 (0%) | 0% | 227.0 | 2,219,131 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 228.04 per share. | 04 Feb 2025 | 1,400 | 0 (0%) | 0% | 228.0 | 319,259 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 07 Jan 2025 | 41,760 | 41,760 (0%) | 0% | 6.5 | 271,440 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 175.46 per share. | 07 Jan 2025 | 19,251 | 22,509 (0%) | 0% | 175.5 | 3,377,728 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 176.67 per share. | 07 Jan 2025 | 11,310 | 11,199 (0%) | 0% | 176.7 | 1,998,090 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 177.42 per share. | 07 Jan 2025 | 4,260 | 6,939 (0%) | 0% | 177.4 | 755,810 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 178.39 per share. | 07 Jan 2025 | 5,638 | 1,301 (0%) | 0% | 178.4 | 1,005,766 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 179.18 per share. | 07 Jan 2025 | 1,301 | 0 (0%) | 0% | 179.2 | 233,119 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2025 | 542,880 | 2,714,407 | - | - | Share Option (Right to Buy) |