52,081
XNAS Volume
High volume+loss today
XNAS 04 Apr, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| J. Kupfer David | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2024 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| Hans Hasler Peter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2024 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| Luthringer Remy | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2024 | 105,000 | 105,000 | - | - | Employee Stock Option (right to buy) | |
| Race Geoffrey | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2024 | 95,000 | 95,000 | - | - | Employee Stock Option (right to buy) | |
| Frederick Ahlholm W. | SVP, CFO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2024 | 47,500 | 47,500 | - | - | Employee Stock Option (right to buy) | |
| Jan van Heek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2024 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| Laghrissi-Thode Fouzia | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2024 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| Frederick W. Ahlholm | SVP, CFO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2023 | 19,843 | 21,098 (0%) | 0% | 0 | Common Stock | |
| Frederick W. Ahlholm | SVP, CFO and Secretary | Sale of securities on an exchange or to another person at price $ 4.48 per share. | 28 Apr 2023 | 3,580 | 17,518 (0%) | 0% | 4.5 | 16,038 | Common Stock |
| Geoffrey Race | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2023 | 46,987 | 73,406 (0%) | 0% | 0 | Common Stock | |
| Geoffrey Race | President | Sale of securities on an exchange or to another person at price $ 3.85 per share. | 28 Apr 2023 | 22,082 | 51,324 (0%) | 0% | 3.9 | 85,016 | Common Stock |
| Remy Luthringer | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2023 | 88,077 | 96,388 (0%) | 0% | 0 | Common Stock | |
| Remy Luthringer | Director, CEO | Sale of securities on an exchange or to another person at price $ 3.85 per share. | 28 Apr 2023 | 23,753 | 72,635 (0%) | 0% | 3.8 | 91,449 | Common Stock |
| Remy Luthringer | Director, CEO | Sale of securities on an exchange or to another person at price $ 3.76 per share. | 28 Apr 2023 | 3,641 | 68,994 (0%) | 0% | 3.8 | 13,690 | Common Stock |
| Frederick W. Ahlholm | SVP, CFO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 26,000 | 26,000 | - | - | Employee Stock Option (right to buy) | |
| Geoffrey Race | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 38,000 | 38,000 | - | - | Employee Stock Option (right to buy) | |
| Remy Luthringer | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2022 | 45,000 | 45,000 | - | - | Employee Stock Option (right to buy) | |
| William F. Doyle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2022 | 2,500 | 2,500 | - | - | Stock Option (right to buy) | |
| Hans Peter Hasler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2022 | 2,500 | 2,500 | - | - | Stock Option (right to buy) | |
| Jan van Heek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2022 | 2,500 | 2,500 | - | - | Stock Option (right to buy) | |
| Jeryl L. Hilleman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2022 | 2,500 | 2,500 | - | - | Stock Option (right to buy) | |
| Fouzia Laghrissi-Thode | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2022 | 2,500 | 2,500 | - | - | Stock Option (right to buy) | |
| David J. Kupfer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2022 | 2,500 | 2,500 | - | - | Stock Option (right to buy) | |
| Frederick W. Ahlholm | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2022 | 180,000 | 180,000 | - | - | Employee Stock Option (right to buy) | |
| Geoffrey Race | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2022 | 200,000 | 200,000 | - | - | Employee Stock Option (right to buy) | |
| Remy Luthringer | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2022 | 505,000 | 505,000 | - | - | Employee Stock Option (right to buy) | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2020 | 5,000 | 11,884 (0%) | 0% | - | Common Stock | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2020 | 5,000 | 0 | - | - | Restricted Stock Unit | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 2.64 per share. | 14 Dec 2020 | 1,845 | 10,039 (0%) | 0% | 2.6 | 4,871 | Common Stock |
| Geoff Race | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2020 | 12,500 | 0 | - | - | Restricted Stock Unit | |
| Geoff Race | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2020 | 12,500 | 217,544 (0%) | 0% | - | Common Stock | |
| Geoff Race | EVP, CFO & CBO | Sale of securities on an exchange or to another person at price $ 2.64 per share. | 14 Dec 2020 | 6,190 | 211,354 (0%) | 0% | 2.6 | 16,342 | Common Stock |
| Joseph Reilly | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 2.64 per share. | 14 Dec 2020 | 3,228 | 31,747 (0%) | 0% | 2.6 | 8,522 | Common Stock |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2020 | 8,750 | 0 | - | - | Restricted Stock Unit | |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2020 | 8,750 | 34,975 (0%) | 0% | - | Common Stock | |
| Remy Luthringer | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2020 | 18,750 | 0 | - | - | Restricted Stock Unit | |
| Remy Luthringer | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2020 | 18,750 | 67,790 (0%) | 0% | - | Common Stock | |
| Remy Luthringer | Director, CEO | Sale of securities on an exchange or to another person at price $ 2.64 per share. | 14 Dec 2020 | 1,300 | 66,490 (0%) | 0% | 2.6 | 3,432 | Common Stock |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Oct 2020 | 85,000 | 85,000 | - | - | Employee Stock Option (right to buy) | |
| Geoff Race | EVP, CFO & CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Oct 2020 | 140,000 | 140,000 | - | - | Employee Stock Option (right to buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Oct 2020 | 85,000 | 85,000 | - | - | Employee Stock Option (right to buy) | |
| Remy Luthringer | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Oct 2020 | 200,000 | 200,000 | - | - | Employee Stock Option (right to buy) | |
| Michael Davidson | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Oct 2020 | 85,000 | 85,000 | - | - | Employee Stock Option (right to buy) | |
| Jay B. Saoud | SVP and Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Oct 2020 | 100,000 | 100,000 | - | - | Employee Stock Option (right to buy) | |
| Devin Whittemore Smith | SVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Oct 2020 | 85,000 | 85,000 | - | - | Employee Stock Option (right to buy) | |
| Jan Van Heek | Director | Purchase of securities on an exchange or from another person at price $ 2.97 per share. | 10 Sep 2020 | 7,000 | 20,333 (0%) | 0% | 3.0 | 20,790 | Common Stock |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2020 | 137,784 | 137,784 | - | - | Employee Stock Option (right to buy) | |
| Geoff Race | EVP, CFO & CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2020 | 275,568 | 275,568 | - | - | Employee Stock Option (right to buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2020 | 153,531 | 153,531 | - | - | Employee Stock Option (right to buy) | |
| Remy Luthringer | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2020 | 354,302 | 354,302 | - | - | Employee Stock Option (right to buy) | |
| Michael Davidson | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2020 | 137,784 | 137,784 | - | - | Employee Stock Option (right to buy) | |
| Jay B. Saoud | SVP and Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2020 | 236,202 | 236,202 | - | - | Employee Stock Option (right to buy) | |
| Rick Russell | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2020 | 185,025 | 185,025 | - | - | Employee Stock Option (right to buy) | |
| Devin Whittemore Smith | SVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2020 | 153,531 | 153,531 | - | - | Employee Stock Option (right to buy) | |
| William F. Doyle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2020 | 40,000 | 40,000 | - | - | Stock Option (right to buy) | |
| Hans Peter Hasler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Jan Van Heek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Jeryl L. Hilleman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Fouzia Laghrissi-Thode | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| David J. Kupfer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2020 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 26 May 2020 | 8,339 | 6,884 (0%) | 0% | 15 | 125,085 | Common Stock |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2019 | 37,216 | 37,216 | - | - | Employee Stock Option (right to buy) | |
| Geoffrey Race | EVP, CFO & CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2019 | 74,432 | 74,432 | - | - | Employee Stock Option (right to buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2019 | 41,469 | 41,469 | - | - | Employee Stock Option (right to buy) | |
| Remy Luthringer | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2019 | 95,698 | 95,698 | - | - | Employee Stock Option (right to buy) | |
| Michael Davidson | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2019 | 37,216 | 37,216 | - | - | Employee Stock Option (right to buy) | |
| Jay B. Saoud | SVP and Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2019 | 63,798 | 63,798 | - | - | Employee Stock Option (right to buy) | |
| Rick Russell | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2019 | 49,975 | 49,975 | - | - | Employee Stock Option (right to buy) | |
| Devin Whittemore Smith | SVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Dec 2019 | 41,469 | 41,469 | - | - | Employee Stock Option (right to buy) | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 7.10 per share. | 14 Dec 2019 | 1,557 | 15,223 (0%) | 0% | 7.1 | 11,055 | Common Stock |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2019 | 5,000 | 5,000 | - | - | Restricted Stock Unit | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2019 | 5,000 | 16,780 (0%) | 0% | - | Common Stock | |
| Geoffrey Race | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2019 | 12,500 | 210,870 (0%) | 0% | - | Common Stock | |
| Geoffrey Race | EVP, CFO & CBO | Sale of securities on an exchange or to another person at price $ 7.10 per share. | 14 Dec 2019 | 5,826 | 205,044 (0%) | 0% | 7.1 | 41,365 | Common Stock |
| Geoffrey Race | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2019 | 12,500 | 12,500 | - | - | Restricted Stock Unit | |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2019 | 8,750 | 28,949 (0%) | 0% | - | Common Stock | |
| Joseph Reilly | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 7.10 per share. | 14 Dec 2019 | 2,724 | 26,225 (0%) | 0% | 7.1 | 19,340 | Common Stock |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2019 | 8,750 | 8,750 | - | - | Restricted Stock Unit | |
| Remy Luthringer | Director, CEO | Sale of securities on an exchange or to another person at price $ 7.10 per share. | 14 Dec 2019 | 2,412 | 49,040 (0%) | 0% | 7.1 | 17,125 | Common Stock |
| Remy Luthringer | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2019 | 18,750 | 51,452 (0%) | 0% | - | Common Stock | |
| Remy Luthringer | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2019 | 18,750 | 18,750 | - | - | Restricted Stock Unit | |
| Rick Russell | President | Sale of securities on an exchange or to another person at price $ 7.42 per share. | 12 Dec 2019 | 3,113 | 33,770 (0%) | 0% | 7.4 | 23,098 | Common Stock |
| William F. Doyle | Director | Purchase of securities on an exchange or from another person at price $ 5.50 per share. | 27 Jun 2019 | 3,500 | 26,111 (0%) | 0% | 5.5 | 19,250 | Common Stock |
| Hans Peter Hasler | Director | Purchase of securities on an exchange or from another person at price $ 5.60 per share. | 26 Jun 2019 | 10,000 | 10,000 (0%) | 0% | 5.6 | 56,000 | Common Stock |
| Jan van Heek | Director | Purchase of securities on an exchange or from another person at price $ 5.37 per share. | 26 Jun 2019 | 10,000 | 13,333 (0%) | 0% | 5.4 | 53,700 | Common Stock |
| Jeryl L. Hilleman | Director | Purchase of securities on an exchange or from another person at price $ 5.25 per share. | 26 Jun 2019 | 1,000 | 1,000 (0%) | 0% | 5.3 | 5,250 | Common Stock |
| David J. Kupfer | Director | Purchase of securities on an exchange or from another person at price $ 5.55 per share. | 26 Jun 2019 | 10,000 | 219,188 (0%) | 0% | 5.6 | 55,500 | Common Stock |
| William F. Doyle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2019 | 20,000 | 20,000 | - | - | Stock option (right to buy) | |
| William F. Doyle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Hans Peter Hasler | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Jan van Heek | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Jeryl L. Hilleman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Fouzia Laghrissi-Thode | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| David J. Kupfer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| William F. Doyle | None | Purchase of securities on an exchange or from another person at price $ 6.50 per share. | 20 Dec 2018 | 2,000 | 22,611 (0%) | 0% | 6.5 | 13,000 | Common Stock |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2018 | 5,000 | 10,000 | - | - | Restricted Stock Unit | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2018 | 5,000 | 13,339 (0%) | 0% | 0 | Common Stock | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 7.46 per share. | 14 Dec 2018 | 1,559 | 11,780 (0%) | 0% | 7.5 | 11,630 | Common Stock |
| Geoff Race | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2018 | 12,500 | 25,000 | - | - | Restricted Stock Unit | |
| Geoff Race | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2018 | 12,500 | 204,369 (0%) | 0% | 0 | Common Stock | |
| Geoff Race | EVP, CFO & CBO | Sale of securities on an exchange or to another person at price $ 7.46 per share. | 14 Dec 2018 | 5,999 | 198,370 (0%) | 0% | 7.5 | 44,753 | Common Stock |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2018 | 8,750 | 17,500 | - | - | Restricted Stock Unit | |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2018 | 8,750 | 22,927 (0%) | 0% | 0 | Common Stock | |
| Joseph Reilly | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 7.46 per share. | 14 Dec 2018 | 2,728 | 20,199 (0%) | 0% | 7.5 | 20,351 | Common Stock |
| Remy Luthringer | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2018 | 18,750 | 35,306 (0%) | 0% | 0 | Common Stock | |
| Remy Luthringer | Director, CEO | Sale of securities on an exchange or to another person at price $ 7.46 per share. | 14 Dec 2018 | 2,604 | 32,702 (0%) | 0% | 7.5 | 19,426 | Common Stock |
| Remy Luthringer | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2018 | 18,750 | 37,500 | - | - | Restricted Stock Unit | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2018 | 120,000 | 120,000 | - | - | Employee Stock Option (right to buy) | |
| Geoff Race | EVP, CFO & CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2018 | 175,000 | 175,000 | - | - | Employee Stock Option (right to buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2018 | 120,000 | 120,000 | - | - | Employee Stock Option (right to buy) | |
| Remy Luthringer | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2018 | 410,000 | 410,000 | - | - | Employee Stock Option (right to buy) | |
| Michael Davidson | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2018 | 175,000 | 175,000 | - | - | Employee Stock Option (right to buy) | |
| Jay B. Saoud | SVP and Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2018 | 96,000 | 96,000 | - | - | Employee Stock Option (right to buy) | |
| Rick Russell | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2018 | 260,000 | 260,000 | - | - | Employee Stock Option (right to buy) | |
| Rick Russell | President | Sale of securities on an exchange or to another person at price $ 7.96 per share. | 11 Dec 2018 | 3,117 | 36,883 (0%) | 0% | 8.0 | 24,811 | Common Stock |
| Devin Whittemore Smith | SVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2018 | 120,000 | 120,000 | - | - | Employee Stock Option (right to buy) | |
| William F. Doyle | None | Purchase of securities on an exchange or from another person at price $ 8.00 per share. | 10 Dec 2018 | 2,000 | 16,611 (0%) | 0% | 8 | 16,000 | Common Stock |
| William F. Doyle | None | Purchase of securities on an exchange or from another person at price $ 7.95 per share. | 10 Dec 2018 | 4,000 | 20,611 (0%) | 0% | 8.0 | 31,800 | Common Stock |
| William F. Doyle | None | Purchase of securities on an exchange or from another person at price $ 8.20 per share. | 20 Nov 2018 | 2,000 | 14,611 (0%) | 0% | 8.2 | 16,400 | Common Stock |
| William F. Doyle | None | Purchase of securities on an exchange or from another person at price $ 10.00 per share. | 11 Oct 2018 | 600 | 12,611 (0%) | 0% | 10 | 6,000 | Common Stock |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2018 | 15,000 | 27,400 | - | - | Employee Stock Option (Right to Buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2018 | 10,000 | 47,524 | - | - | Employee Stock Option (Right to Buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.71 per share. | 01 Oct 2018 | 15,000 | 29,177 (0%) | 0% | 4.7 | 70,650 | Common Stock |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 01 Oct 2018 | 10,000 | 39,177 (0%) | 0% | 5.2 | 51,900 | Common Stock |
| Joseph Reilly | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 12.02 per share. | 01 Oct 2018 | 23,300 | 15,877 (0%) | 0% | 12.0 | 280,066 | Common Stock |
| Joseph Reilly | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 12.62 per share. | 01 Oct 2018 | 1,700 | 14,177 (0%) | 0% | 12.6 | 21,454 | Common Stock |
| William F. Doyle | None | Purchase of securities on an exchange or from another person at price $ 10.50 per share. | 17 Sep 2018 | 1,800 | 12,011 (0%) | 0% | 10.5 | 18,900 | Common Stock |
| William F. Doyle | None | Purchase of securities on an exchange or from another person at price $ 10.50 per share. | 13 Sep 2018 | 2,000 | 10,011 (0%) | 0% | 10.5 | 21,000 | Common Stock |
| William F. Doyle | None | Purchase of securities on an exchange or from another person at price $ 10.50 per share. | 13 Sep 2018 | 200 | 10,211 (0%) | 0% | 10.5 | 2,100 | Common Stock |
| William F. Doyle | None | Purchase of securities on an exchange or from another person at price $ 9.72 per share. | 10 Sep 2018 | 4,011 | 8,011 (0%) | 0% | 9.7 | 38,987 | Common Stock |
| William F. Doyle | None | Purchase of securities on an exchange or from another person at price $ 9.88 per share. | 10 Sep 2018 | 4,000 | 4,000 (0%) | 0% | 9.9 | 39,520 | Common Stock |
| Joseph Reilly | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 10.00 per share. | 23 Aug 2018 | 25,000 | 14,177 (0%) | 0% | 10 | 250,000 | Common Stock |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2018 | 25,000 | 42,400 | - | - | Employee Stock Option (Right to Buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.71 per share. | 23 Aug 2018 | 25,000 | 39,177 (0%) | 0% | 4.7 | 117,750 | Common Stock |
| William F. Doyle | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Devin Whittemore Smith | SVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2018 | 200,000 | 200,000 | - | - | Employee Stock Option (Righ to Buy) | |
| Jeryl L. Hilleman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jul 2018 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| William F. Doyle | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Hans Peter Hasler | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Jan Van Heek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Fouzia Laghrissi-Thode | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| David J. Kupfer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Marc D. Beer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2018 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Marc D. Beer | None | Sale or transfer of securities back to the company at price $ 0.00 per share. | 31 Jan 2018 | 12,500 | 0 | - | - | Stock Option (Right to Buy) | |
| Marc D. Beer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2018 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Marc D. Beer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2018 | 80,356 | 80,356 | - | - | Stock Option (Right to Buy) | |
| Marc D. Beer | None | Sale or transfer of securities back to the company at price $ 0.00 per share. | 31 Jan 2018 | 12,500 | 0 | - | - | Stock Option (Right to Buy) | |
| Marc D. Beer | None | Sale or transfer of securities back to the company at price $ 0.00 per share. | 31 Jan 2018 | 80,356 | 0 | - | - | Stock Option (Right to Buy) | |
| Marc D. Beer | None | Sale or transfer of securities back to the company at price $ 0.00 per share. | 31 Jan 2018 | 127,513 | 0 | - | - | Stock Option (Right to Buy) | |
| Marc D. Beer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2018 | 127,513 | 127,513 | - | - | Stock Option (Right to Buy) | |
| Marc D. Beer | None | Sale or transfer of securities back to the company at price $ 0.00 per share. | 31 Jan 2018 | 7,500 | 0 | - | - | Stock Option (Right to Buy) | |
| Marc D. Beer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2018 | 7,500 | 7,500 | - | - | Stock Option (Right to Buy) | |
| Remy Luthringer | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2018 | 200,000 | 200,000 | - | - | Employee Stock Option (Right to Buy) | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 5.80 per share. | 13 Dec 2017 | 1,661 | 8,339 (0%) | 0% | 5.8 | 9,634 | Common Stock |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2017 | 120,000 | 120,000 | - | - | Employee Stock Option (Right to Buy) | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2017 | 5,000 | 10,000 (0%) | 0% | 0 | Common Stock | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2017 | 5,000 | 15,000 | - | - | Restricted Stock Unit | |
| Geoff Race | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2017 | 12,500 | 37,500 | - | - | Restricted Stock Unit | |
| Geoff Race | EVP, CFO & CBO | Sale of securities on an exchange or to another person at price $ 5.79 per share. | 13 Dec 2017 | 5,829 | 191,869 (0%) | 0% | 5.8 | 33,750 | Common Stock |
| Geoff Race | EVP, CFO & CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2017 | 12,500 | 197,698 (0%) | 0% | 0 | Common Stock | |
| Geoff Race | EVP, CFO & CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2017 | 200,000 | 200,000 | - | - | Employee Stock Option (Right to Buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2017 | 8,750 | 26,250 | - | - | Restricted Stock Unit | |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2017 | 8,750 | 17,083 (0%) | 0% | 0 | Common Stock | |
| Joseph Reilly | SVP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2017 | 120,000 | 120,000 | - | - | Employee Stock Option (Right to Buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 5.80 per share. | 13 Dec 2017 | 2,906 | 14,177 (0%) | 0% | 5.8 | 16,855 | Common Stock |
| Remy Luthringer | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2017 | 18,750 | 56,250 | - | - | Restricted Stock Unit | |
| Remy Luthringer | Director, CEO | Sale of securities on an exchange or to another person at price $ 5.85 per share. | 13 Dec 2017 | 2,194 | 16,556 (0%) | 0% | 5.9 | 12,835 | Common Stock |
| Remy Luthringer | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2017 | 18,750 | 18,750 (0%) | 0% | 0 | Common Stock | |
| Remy Luthringer | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2017 | 350,000 | 350,000 | - | - | Employee Stock Option (Right to Buy) | |
| Michael Davidson | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2017 | 125,000 | 125,000 | - | - | Employee Stock Option (Right to Buy) | |
| Jay B. Saoud | SVP and Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2017 | 175,000 | 175,000 | - | - | Employee Stock Option (Right to Buy) | |
| Rick Russell | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2017 | 775,000 | 775,000 | - | - | Employee Stock option (Right to Buy) | |
| Rick Russell | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2017 | 40,000 | 40,000 (0%) | 0% | 0 | Common Stock | |
| William F. Doyle | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Dec 2017 | 40,000 | 40,000 | - | - | Option Grant (Right to Buy) | |
| Hans Peter Hasler | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Dec 2017 | 40,000 | 40,000 | - | - | Option Grant (Right to Buy) | |
| Jay B. Saoud | SVP and Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2017 | 100,000 | 100,000 | - | - | Employee Stock Option (Right to Buy) | |
| Nico Vandervelpen | None | Sale or transfer of securities back to the company at price $ 0.00 per share. | 24 Jul 2017 | 25,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Nico Vandervelpen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Nico Vandervelpen | None | Sale or transfer of securities back to the company at price $ 0.00 per share. | 24 Jul 2017 | 12,500 | 0 | - | - | Stock Option (Right to Buy) | |
| Nico Vandervelpen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Nico Vandervelpen | None | Sale or transfer of securities back to the company at price $ 0.00 per share. | 24 Jul 2017 | 12,500 | 0 | - | - | Stock Option (Right to Buy) | |
| Nico Vandervelpen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2017 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.71 per share. | 01 Jun 2017 | 7,250 | 26,631 (0%) | 0% | 4.7 | 34,148 | Common Stock |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2017 | 7,250 | 49,750 | - | - | Employee Stock Option (Right to Buy) | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 11.00 per share. | 01 Jun 2017 | 10,381 | 5,000 (0%) | 0% | 11 | 114,191 | Common Stock |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2017 | 14,381 | 43,143 | - | - | Employee Stock Option (Right to Buy) | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 10.00 per share. | 01 Jun 2017 | 11,250 | 15,381 (0%) | 0% | 10 | 112,500 | Common Stock |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 01 Jun 2017 | 14,381 | 19,381 (0%) | 0% | 5.2 | 74,637 | Common Stock |
| Marc D. Beer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Jan Van Heek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Mark S. Levine | SVP,General Counsel & Sec. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 01 Jun 2017 | 17,500 | 17,500 (0%) | 0% | 5.2 | 90,825 | Common Stock |
| Mark S. Levine | SVP,General Counsel & Sec. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2017 | 17,500 | 39,774 | - | - | Employee Stock Option (Right to Buy) | |
| Mark S. Levine | SVP,General Counsel & Sec. | Sale of securities on an exchange or to another person at price $ 11.00 per share. | 01 Jun 2017 | 17,500 | 0 (0%) | 0% | 11 | 192,500 | Common Stock |
| Nico Vandervelpen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Fouzia Laghrissi-Thode | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| David J. Kupfer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Marc D. Beer | None | Purchase of securities on an exchange or from another person at price $ 8.34 per share. | 17 Mar 2017 | 25,000 | 25,000 (0%) | 0% | 8.3 | 208,500 | Common Stock |
| Marc D. Beer | None | Purchase of securities on an exchange or from another person at price $ 7.89 per share. | 17 Mar 2017 | 25,000 | 50,000 (0%) | 0% | 7.9 | 197,250 | Common Stock |
| Geoff Race | EVP, CFO & CBO | Sale of securities on an exchange or to another person at price $ 11.02 per share. | 03 Feb 2017 | 19,758 | 186,890 (0%) | 0% | 11.0 | 217,733 | Common Stock |
| Geoff Race | EVP, CFO & CBO | Sale of securities on an exchange or to another person at price $ 11.00 per share. | 03 Feb 2017 | 1,692 | 185,198 (0%) | 0% | 11 | 18,612 | Common Stock |
| Remy Luthringer | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 11.00 per share. | 03 Feb 2017 | 2,185 | 0 (0%) | 0% | 11 | 24,035 | Common Stock |
| Remy Luthringer | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.71 per share. | 03 Feb 2017 | 2,185 | 2,185 (0%) | 0% | 4.7 | 10,291 | Common Stock |
| Remy Luthringer | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.71 per share. | 03 Feb 2017 | 32,096 | 32,096 (0%) | 0% | 4.7 | 151,172 | Common Stock |
| Remy Luthringer | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 11.02 per share. | 03 Feb 2017 | 32,096 | 0 (0%) | 0% | 11.0 | 353,698 | Common Stock |
| Remy Luthringer | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2017 | 32,096 | 287,904 | - | - | Stock Option (Right to Buy) | |
| Remy Luthringer | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2017 | 2,185 | 285,719 | - | - | Stock Option (Right to Buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jan 2017 | 1,600 | 67,400 | - | - | Stock Option (Right to Buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.71 per share. | 11 Jan 2017 | 1,600 | 9,933 (0%) | 0% | 4.7 | 7,536 | Common Stock |
| Joseph Reilly | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 12.03 per share. | 11 Jan 2017 | 1,600 | 8,333 (0%) | 0% | 12.0 | 19,248 | Common Stock |
| Mark S. Levine | SVP,General Counsel & Sec. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2017 | 17,250 | 51,750 | - | - | Stock Option (Right to Buy) | |
| Mark S. Levine | SVP,General Counsel & Sec. | Sale of securities on an exchange or to another person at price $ 12.00 per share. | 04 Jan 2017 | 17,500 | 0 (0%) | 0% | 12 | 210,000 | Common Stock |
| Mark S. Levine | SVP,General Counsel & Sec. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.19 per share. | 04 Jan 2017 | 250 | 17,500 (0%) | 0% | 5.2 | 1,298 | Common Stock |
| Mark S. Levine | SVP,General Counsel & Sec. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.71 per share. | 04 Jan 2017 | 17,250 | 17,250 (0%) | 0% | 4.7 | 81,248 | Common Stock |
| Mark S. Levine | SVP,General Counsel & Sec. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2017 | 250 | 57,274 | - | - | Stock Option (Right to Buy) | |
| Michael Davidson | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2017 | 145,000 | 145,000 | - | - | Stock Option (Right to Buy) | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2016 | 12,000 | 57,000 | - | - | Employee Stock Option (Right to Buy) | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2016 | 12,000 | 22,000 | - | - | Common Stock | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 27 Dec 2016 | 17,000 | 5,000 | - | - | Common Stock | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2016 | 20,000 | 20,000 | - | - | Restricted Stock Unit | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2016 | 35,000 | 35,000 | - | - | Employee Stock Option (Right to Buy) | |
| Geoff Race | EVP, CFO & Chief Business Off. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2016 | 50,000 | 50,000 | - | - | Restricted Stock Unit | |
| Geoff Race | EVP, CFO & Chief Business Off. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2016 | 100,000 | 100,000 | - | - | Employee Stock Option (Right to Buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2016 | 35,000 | 35,000 | - | - | Restricted Stock Unit | |
| Joseph Reilly | SVP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2016 | 60,000 | 60,000 | - | - | Employee Stock Option (Right to Buy) | |
| Remy Luthringer | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2016 | 75,000 | 75,000 | - | - | Restricted Stock Unit | |
| Remy Luthringer | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2016 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Mark S. Levine | SVP,General Counsel & Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2016 | 20,000 | 20,000 | - | - | Restricted Stock Units | |
| Mark S. Levine | SVP,General Counsel & Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2016 | 35,000 | 35,000 | - | - | Employee Stock Option (Right to Buy) | |
| Michèle Ollier | Director, Ten Percent Owner | 12 Dec 2016 | 202,634 | 0 | - | - | Warrant Shares | ||
| Michèle Ollier | Director, Ten Percent Owner | 12 Dec 2016 | 202,634 | 4,690,906 | - | - | Common Stock | ||
| Francesco De Rubertis | Director, Ten Percent Owner | 12 Dec 2016 | 202,634 | 0 | - | - | Warrant Shares | ||
| Francesco De Rubertis | Director, Ten Percent Owner | 12 Dec 2016 | 202,634 | 4,690,906 | - | - | Common Stock | ||
| Michèle Ollier | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 10 Aug 2016 | 1,000,000 | 4,488,272 | - | - | Common Stock | |
| Francesco De Rubertis | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 10 Aug 2016 | 1,000,000 | 4,488,272 | - | - | Common Stock | |
| David J. Kupfer | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Jun 2016 | 27,700 | 209,188 | - | - | Common Stock | |
| David J. Kupfer | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Jun 2016 | 27,935 | 27,935 | - | - | Common Stock | |
| Jan Van Heek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| Marc D. Beer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| Nico Vandervelpen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| Fouzia Laghrissi-Thode | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| David J. Kupfer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (right to buy) | |
| David J. Kupfer | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 17 Mar 2016 | 181,488 | 181,488 | - | - | Common Stock | |
| Frederick W. Ahlholm | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2015 | 69,000 | 69,000 | - | - | Stock Option (right to buy) | |
| Geoff Race | EVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2015 | 175,000 | 175,000 | - | - | Stock Option (right to buy) | |
| Joseph Reilly | SVP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2015 | 69,000 | 69,000 | - | - | Stock Option (right to buy) | |
| Remy Luthringer | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2015 | 320,000 | 320,000 | - | - | Stock Option (right to buy) | |
| Mark S. Levine | SVP,General Counsel & Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2015 | 69,000 | 69,000 | - | - | Stock Option (right to buy) | |
| Nico Vandervelpen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Dec 2015 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| David J. Kupfer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Nov 2015 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Fouzia Laghrissi-Thode | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2015 | 25,000 | 25,000 | - | - | Stock Option (right to buy) | |
| Frederick W. Ahlholm | VP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2015 | 57,524 | 57,524 | - | - | Stock Option (right to buy) | |
| Geoff Race | EVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2015 | 213,133 | 213,133 | - | - | Stock Option (right to buy) | |
| Joseph Reilly | VP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2015 | 57,524 | 57,524 | - | - | Stock Option (right to buy) | |
| Remy Luthringer | Director, President, CEO & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2015 | 399,623 | 399,623 | - | - | Stock Option (right to buy) | |
| Mark S. Levine | VP,General Counsel & Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2015 | 57,524 | 57,524 | - | - | Stock Option (right to buy) | |
| Michèle Ollier | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Mar 2015 | 202,634 | 202,634 | - | - | Warrant Shares | |
| Michèle Ollier | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Mar 2015 | 202,634 | 5,488,272 | - | - | Common Stock | |
| Francesco De Rubertis | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Mar 2015 | 202,634 | 202,634 | - | - | Warrant Shares | |
| Francesco De Rubertis | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Mar 2015 | 202,634 | 5,488,272 | - | - | Common Stock | |
| Jan Van Heek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2015 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Marc D. Beer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2015 | 7,500 | 7,500 | - | - | Stock Option (right to buy) | |
| Mark S. Levine | Vice President,General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Sep 2014 | 93,541 | 93,541 | - | - | Employee Stock Option (Right to Buy) | |
| Michèle Ollier | Director, Ten Percent Owner | 07 Jul 2014 | 114,077 | 0 | - | - | Convertible Promissory Note | ||
| Michèle Ollier | Director, Ten Percent Owner | 07 Jul 2014 | 61,922 | 0 | - | - | Convertible Promissory Note | ||
| Michèle Ollier | Director, Ten Percent Owner | 07 Jul 2014 | 114,077 | 3,602,883 | - | - | Common Stock | ||
| Michèle Ollier | Director, Ten Percent Owner | 07 Jul 2014 | 61,922 | 3,664,805 | - | - | Common Stock | ||
| Michèle Ollier | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 07 Jul 2014 | 1,287,500 | 4,952,305 | - | - | Common Stock | |
| Michèle Ollier | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 07 Jul 2014 | 333,333 | 5,285,638 | - | - | Common Stock | |
| Francesco De Rubertis | Director, Ten Percent Owner | 07 Jul 2014 | 114,077 | 0 | - | - | Convertible Promissory Note | ||
| Francesco De Rubertis | Director, Ten Percent Owner | 07 Jul 2014 | 61,922 | 0 | - | - | Convertible Promissory Note | ||
| Francesco De Rubertis | Director, Ten Percent Owner | 07 Jul 2014 | 114,077 | 3,602,883 | - | - | Common Stock | ||
| Francesco De Rubertis | Director, Ten Percent Owner | 07 Jul 2014 | 61,922 | 3,664,805 | - | - | Common Stock | ||
| Francesco De Rubertis | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 07 Jul 2014 | 1,287,500 | 4,952,305 | - | - | Common Stock | |
| Francesco De Rubertis | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 07 Jul 2014 | 333,333 | 5,285,638 | - | - | Common Stock | |
| Lorenzo Pellegrini | Director, Ten Percent Owner | 07 Jul 2014 | 114,078 | 0 | - | - | Convertible Promissory Note | ||
| Lorenzo Pellegrini | Director, Ten Percent Owner | 07 Jul 2014 | 61,923 | 0 | - | - | Convertible Promissory Note | ||
| Lorenzo Pellegrini | Director, Ten Percent Owner | 07 Jul 2014 | 114,078 | 3,083,789 | - | - | Common Stock | ||
| Lorenzo Pellegrini | Director, Ten Percent Owner | 07 Jul 2014 | 61,923 | 3,145,712 | - | - | Common Stock | ||
| Lorenzo Pellegrini | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 07 Jul 2014 | 737,500 | 3,883,212 | - | - | Common Stock | |
| G. Jan Van Heek | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2014 | 51,967 | 51,967 | - | - | Stock Option (Right to Buy) | |
| G. Jan Van Heek | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 30 Jun 2014 | 3,333 | 3,333 | - | - | Common Stock | |
| Marc D. Beer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2014 | 127,513 | 127,513 | - | - | Stock Option (Right to Buy) | |
| Frederick W. Ahlholm | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2014 | 93,541 | 93,541 | - | - | Employee Stock Option (Right to Buy) | |
| Frederick W. Ahlholm | Chief Accounting Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 30 Jun 2014 | 10,000 | 10,000 | - | - | Common Stock | |
| Rogerio Coelho Vivaldi | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2014 | 498,621 | 498,621 | - | - | Employee Stock Option (right to buy) | |
| Rogerio Coelho Vivaldi | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 30 Jun 2014 | 41,667 | 41,667 | - | - | Common Stock | |
| Geoff Race | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2014 | 97,143 | 97,143 | - | - | Employee Stock Option (Right to Buy) | |
| Geoff Race | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2014 | 249,442 | 346,585 | - | - | Employee Stock Option (Right to Buy) | |
| Geoff Race | EVP and CFO | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 30 Jun 2014 | 33,333 | 206,648 | - | - | Common Stock | |
| Joseph Reilly | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2014 | 93,541 | 93,541 | - | - | Employee Stock Option (Right to Buy) | |
| Joseph Reilly | Chief Business Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 30 Jun 2014 | 8,333 | 8,333 | - | - | Common Stock | |
| Remy Luthringer | EVP and Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2014 | 441,973 | 441,973 | - | - | Employee Stock Option (Right to Buy) | |
| Remy Luthringer | EVP and Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2014 | 207,869 | 649,842 | - | - | Employee Stock Option (Right to Buy) |