510.1K XNAS Volume
XNAS 19 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 50,000 | 25,000 | - | - | Performance Restricted Stock Units | |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 44.21 per share. | 15 Mar 2025 | 27,279 | 138,641 (0%) | 0% | 44.2 | 1,206,122 | Common Stock |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 50,000 | 165,920 (0%) | 0% | - | Common Stock | |
| Peter Radovich | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 44.21 per share. | 15 Mar 2025 | 7,879 | 18,672 (0%) | 0% | 44.2 | 348,364 | Common Stock |
| Peter Radovich | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 14,440 | 26,551 (0%) | 0% | - | Common Stock | |
| Peter Radovich | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 14,440 | 7,220 | - | - | Performance Restricted Stock Units | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 5,315 | 9,547 (0%) | 0% | - | Common Stock | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Sale of securities on an exchange or to another person at price $ 44.21 per share. | 15 Mar 2025 | 2,900 | 6,647 (0%) | 0% | 44.2 | 128,221 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 52,900 | 0 | - | - | Stock Option (right to buy) | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2025 | 5,315 | 2,658 | - | - | Performance Restricted Stock Units | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Sale of securities on an exchange or to another person at price $ 44.36 per share. | 15 Mar 2025 | 1,806 | 4,841 (0%) | 0% | 44.4 | 80,113 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Sale of securities on an exchange or to another person at price $ 44.75 per share. | 15 Mar 2025 | 2,789 | 6,647 (0%) | 0% | 44.7 | 124,802 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Sale of securities on an exchange or to another person at price $ 44.33 per share. | 15 Mar 2025 | 50,111 | 9,436 (0%) | 0% | 44.3 | 2,221,626 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.94 per share. | 15 Mar 2025 | 52,900 | 59,547 (0%) | 0% | 2.9 | 155,526 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 43.95 per share. | 14 Mar 2025 | 21 | 168,672 (0%) | 0% | 44.0 | 923 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 44.11 per share. | 14 Mar 2025 | 528 | 168,651 (0%) | 0% | 44.1 | 23,291 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 43.37 per share. | 10 Mar 2025 | 577 | 167,160 (0%) | 0% | 43.4 | 25,023 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 43.77 per share. | 10 Mar 2025 | 963 | 168,123 (0%) | 0% | 43.8 | 42,155 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 42.66 per share. | 10 Mar 2025 | 758 | 166,583 (0%) | 0% | 42.7 | 32,339 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 43.89 per share. | 06 Mar 2025 | 1,335 | 165,245 (0%) | 0% | 43.9 | 58,597 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 43.21 per share. | 06 Mar 2025 | 580 | 165,825 (0%) | 0% | 43.2 | 25,064 | Common Stock |
| Peter Radovich | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 45.74 per share. | 04 Mar 2025 | 1,169 | 12,111 (0%) | 0% | 45.7 | 53,470 | Common Stock |
| Peter Radovich | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 45.57 per share. | 04 Mar 2025 | 13,681 | 13,280 (0%) | 0% | 45.6 | 623,458 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 44.55 per share. | 04 Mar 2025 | 267 | 163,910 (0%) | 0% | 44.5 | 11,894 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 45.96 per share. | 04 Mar 2025 | 56 | 163,643 (0%) | 0% | 46.0 | 2,574 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 45.55 per share. | 04 Mar 2025 | 1,279 | 163,587 (0%) | 0% | 45.5 | 58,257 | Common Stock |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.94 per share. | 03 Mar 2025 | 40,000 | 155,920 (0%) | 0% | 2.9 | 117,440 | Common Stock |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2025 | 40,000 | 238,487 | - | - | Employee Stock Option (right to buy) | |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 47.19 per share. | 03 Mar 2025 | 20,608 | 115,920 (0%) | 0% | 47.2 | 972,492 | Common Stock |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 46.61 per share. | 03 Mar 2025 | 19,392 | 136,528 (0%) | 0% | 46.6 | 903,861 | Common Stock |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 48.22 per share. | 03 Feb 2025 | 9,102 | 115,920 (0%) | 0% | 48.2 | 438,921 | Common Stock |
| Peter Radovich | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 48.22 per share. | 03 Feb 2025 | 2,627 | 26,961 (0%) | 0% | 48.2 | 126,681 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 1,772 | 5,296 (0%) | 0% | - | Common Stock | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 1,772 | 1,771 | - | - | Restricted Stock Units | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Sale of securities on an exchange or to another person at price $ 48.22 per share. | 31 Jan 2025 | 1,064 | 4,232 (0%) | 0% | 48.2 | 51,309 | Common Stock |
| Eric H. Bjerkholt | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2025 | 2,667 | 35,946 (0%) | 0% | - | Common Stock | |
| Eric H. Bjerkholt | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2025 | 2,667 | 5,333 | - | - | Restricted Stock Units | |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2025 | 12,500 | 25,000 | - | - | Restricted Stock Units | |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2025 | 12,500 | 131,859 (0%) | 0% | - | Common Stock | |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 47.92 per share. | 23 Jan 2025 | 6,837 | 125,022 (0%) | 0% | 47.9 | 327,658 | Common Stock |
| Peter Radovich | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2025 | 5,750 | 32,765 (0%) | 0% | - | Common Stock | |
| Peter Radovich | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 47.92 per share. | 23 Jan 2025 | 3,177 | 29,588 (0%) | 0% | 47.9 | 152,256 | Common Stock |
| Peter Radovich | PRESIDENT AND COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2025 | 5,750 | 11,500 | - | - | Restricted Stock Units | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Sale of securities on an exchange or to another person at price $ 47.92 per share. | 23 Jan 2025 | 902 | 3,524 (0%) | 0% | 47.9 | 43,228 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2025 | 1,500 | 4,426 (0%) | 0% | - | Common Stock | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2025 | 1,500 | 3,000 | - | - | Restricted Stock Units | |
| Eric H. Bjerkholt | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 40,000 | 40,000 | - | - | Stock Option (right to buy) | |
| Eric H. Bjerkholt | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 10,000 | 10,000 | - | - | Restricted Stock Units | |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 153,550 | 153,550 | - | - | Stock Option (right to buy) | |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 75,000 | 75,000 | - | - | Performance Restricted Stock Units | |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 38,390 | 38,390 | - | - | Restricted Stock Units | |
| Peter Radovich | PRESIDENT AND COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 50,000 | 50,000 | - | - | Stock Option (right to buy) | |
| Peter Radovich | PRESIDENT AND COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 21,660 | 21,660 | - | - | Performance Restricted Stock Units | |
| Peter Radovich | PRESIDENT AND COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 12,500 | 12,500 | - | - | Restricted Stock Units | |
| Joanne Quan | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 10,000 | 10,000 | - | - | Restricted Stock Units | |
| Joanne Quan | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 40,000 | 40,000 | - | - | Stock Option (right to buy) | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 4,625 | 4,625 | - | - | Restricted Stock Units | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 18,500 | 18,500 | - | - | Stock Option (right to buy) | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2025 | 7,973 | 7,973 | - | - | Performance Restricted Stock Units | |
| Joanne Quan | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2025 | 12,500 | 25,000 | - | - | Restricted Stock Units | |
| Joanne Quan | CHIEF MEDICAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2025 | 12,500 | 12,618 (0%) | 0% | - | Common Stock | |
| Joanne Quan | CHIEF MEDICAL OFFICER | Sale of securities on an exchange or to another person at price $ 45.86 per share. | 16 Jan 2025 | 6,969 | 5,649 (0%) | 0% | 45.9 | 319,598 | Common Stock |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 42.82 per share. | 07 Jan 2025 | 7,489 | 119,359 (0%) | 0% | 42.8 | 320,644 | Common Stock |
| Peter Radovich | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 42.82 per share. | 07 Jan 2025 | 1,998 | 27,015 (0%) | 0% | 42.8 | 85,545 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jan 2025 | 1,250 | 3,676 (0%) | 0% | - | Common Stock | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Sale of securities on an exchange or to another person at price $ 42.81 per share. | 06 Jan 2025 | 750 | 2,926 (0%) | 0% | 42.8 | 32,111 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jan 2025 | 1,250 | 0 | - | - | Restricted Stock Units | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.94 per share. | 14 Nov 2024 | 2,500 | 4,926 (0%) | 0% | 2.9 | 7,350 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Nov 2024 | 2,500 | 52,900 | - | - | Stock Option (right to buy) | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Sale of securities on an exchange or to another person at price $ 47.10 per share. | 14 Nov 2024 | 2,500 | 2,426 (0%) | 0% | 47.1 | 117,752 | Common Stock |
| Eric H. Bjerkholt | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 21.05 per share. | 08 Nov 2024 | 475 | 33,279 (0%) | 0% | 21.0 | 9,997 | Common Stock |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 21.05 per share. | 08 Nov 2024 | 65 | 126,848 (0%) | 0% | 21.0 | 1,368 | Common Stock |
| Joanne Quan | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 21.04 per share. | 08 Nov 2024 | 118 | 118 (0%) | 0% | 21.0 | 2,483 | Common Stock |
| Michael G. Grey | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Sep 2024 | 102,788 | 186,410 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 37.40 per share. | 18 Sep 2024 | 115 | 162,308 (0%) | 0% | 37.4 | 4,301 | Common Stock |
| Eric H. Bjerkholt | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2024 | 18,334 | 32,804 (0%) | 0% | - | Common Stock | |
| Eric H. Bjerkholt | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2024 | 18,334 | 36,666 | - | - | Restricted Stock Units | |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 41.58 per share. | 06 Sep 2024 | 230 | 162,193 (0%) | 0% | 41.6 | 9,563 | Common Stock |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jul 2024 | 34,013 | 278,487 | - | - | Stock Option (right to buy) | |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.94 per share. | 23 Jul 2024 | 34,013 | 126,783 (0%) | 0% | 2.9 | 99,862 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 1,042 | 2,801 (0%) | 0% | - | Common Stock | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 1,042 | 1,041 | - | - | Restricted Stock Units | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Sale of securities on an exchange or to another person at price $ 34.00 per share. | 01 Jul 2024 | 375 | 2,426 (0%) | 0% | 34 | 12,750 | Common Stock |
| Pamela Vig | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 34.00 per share. | 24 Jun 2024 | 30,559 | 27,406 (0%) | 0% | 34 | 1,039,006 | Common Stock |
| Pamela Vig | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.94 per share. | 24 Jun 2024 | 30,559 | 57,965 (0%) | 0% | 2.9 | 89,721 | Common Stock |
| Pamela Vig | CHIEF SCIENTIFIC OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 30,559 | 125,691 | - | - | Stock Option (right to buy) | |
| Laura A. Brege | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 5,703 | 5,703 | - | - | Restricted Stock Units | |
| Laura A. Brege | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 8,779 | 8,779 | - | - | Stock Option (right to buy) | |
| Michael G. Grey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 5,703 | 5,703 | - | - | Deferred Stock Units | |
| Michael G. Grey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 8,779 | 8,779 | - | - | Stock Option (right to buy) | |
| Timothy P. Walbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 5,703 | 5,703 | - | - | Restricted Stock Units | |
| Timothy P. Walbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 8,779 | 8,779 | - | - | Stock Option (right to buy) | |
| Patrick J. Heron | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 5,703 | 5,703 | - | - | Restricted Stock Units | |
| Patrick J. Heron | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 8,779 | 8,779 | - | - | Stock Option (right to buy) | |
| Saira Ramasastry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2024 | 5,000 | 2,500 | - | - | Stock Option (right to buy) | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 5,703 | 5,703 | - | - | Restricted Stock Units | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 8,779 | 8,779 | - | - | Stock Option (right to buy) | |
| Saira Ramasastry | Director | Sale of securities on an exchange or to another person at price $ 25.68 per share. | 05 Jun 2024 | 5,000 | 0 (0%) | 0% | 25.7 | 128,400 | Common Stock |
| Saira Ramasastry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.12 per share. | 05 Jun 2024 | 5,000 | 5,000 (0%) | 0% | 14.1 | 70,600 | Common Stock |
| Laurent Fischer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 8,779 | 8,779 | - | - | Stock Option (right to buy) | |
| Laurent Fischer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 5,703 | 5,703 | - | - | Deferred Stock Units | |
| William Carl Fairey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 5,703 | 5,703 | - | - | Restricted Stock Units | |
| William Carl Fairey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 8,779 | 8,779 | - | - | Stock Option (right to buy) | |
| Lon Cardon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 5,703 | 5,703 | - | - | Restricted Stock Units | |
| Lon Cardon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 8,779 | 8,779 | - | - | Stock Option (right to buy) | |
| Eric H. Bjerkholt | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 21.05 per share. | 10 May 2024 | 470 | 14,470 (0%) | 0% | 21.0 | 9,892 | Common Stock |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 21.05 per share. | 10 May 2024 | 817 | 92,770 (0%) | 0% | 21.0 | 17,195 | Common Stock |
| Pamela Vig | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 21.04 per share. | 10 May 2024 | 94 | 27,406 (0%) | 0% | 21.0 | 1,978 | Common Stock |
| Eric H. Bjerkholt | CHIEF FINANCIAL OFFICER | Purchase of securities on an exchange or from another person at price $ 24.80 per share. | 27 Mar 2024 | 2,000 | 14,000 (0%) | 0% | 24.8 | 49,600 | Common Stock |
| Peter Radovich | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 25.80 per share. | 25 Mar 2024 | 4,303 | 29,013 (0%) | 0% | 25.8 | 111,017 | Common Stock |
| Eric H. Bjerkholt | CHIEF FINANCIAL OFFICER | Purchase of securities on an exchange or from another person at price $ 25.80 per share. | 18 Mar 2024 | 2,000 | 12,000 (0%) | 0% | 25.8 | 51,600 | Common Stock |
| Vig Pamela | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 26.19 per share. | 02 Feb 2024 | 1,214 | 28,691 (0%) | 0% | 26.2 | 31,797 | Common Stock |
| Peter Radovich | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 26.19 per share. | 02 Feb 2024 | 1,790 | 34,695 (0%) | 0% | 26.2 | 46,883 | Common Stock |
| Longpre Lara | CHIEF DEVELOPMENT OFFICER | Sale of securities on an exchange or to another person at price $ 26.19 per share. | 02 Feb 2024 | 847 | 104,407 (0%) | 0% | 26.2 | 22,184 | Common Stock |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 26.19 per share. | 02 Feb 2024 | 6,013 | 104,112 (0%) | 0% | 26.2 | 157,491 | Common Stock |
| Howe Jolanda | SVP, GLOBAL CONTROLLER | Sale of securities on an exchange or to another person at price $ 26.19 per share. | 31 Jan 2024 | 735 | 1,759 (0%) | 0% | 26.2 | 19,251 | Common Stock |
| Howe Jolanda | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2024 | 1,772 | 2,494 (0%) | 0% | - | Common Stock | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2024 | 1,772 | 3,543 | - | - | Restricted Stock Units | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 4,500 | 4,500 | - | - | Restricted Stock Units | |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 18,000 | 18,000 | - | - | Stock Option (right to buy) | |
| Peetz Christopher | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 37,500 | 37,500 | - | - | Restricted Stock Units | |
| Peter Radovich | PRESIDENT AND COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 17,250 | 17,250 | - | - | Restricted Stock Units | |
| H. Bjerkholt Eric | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Pamela Vig | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 8,000 | 8,000 | - | - | Restricted Stock Units | |
| Longpre Lara | CHIEF DEVELOPMENT OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 8,000 | 8,000 | - | - | Restricted Stock Units | |
| Eric H. Bjerkholt | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 8,000 | 8,000 | - | - | Restricted Stock Units | |
| Lara Longpre | CHIEF DEVELOPMENT OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Vig Pamela | CHIEF SCIENTIFIC OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Peetz Christopher | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 150,000 | 150,000 | - | - | Stock Option (right to buy) | |
| Radovich Peter | PRESIDENT AND COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2024 | 70,000 | 70,000 | - | - | Stock Option (right to buy) | |
| Joanne Quan | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 75,000 | 75,000 | - | - | Stock Option (right to buy) | |
| Joanne Quan | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2024 | 37,500 | 37,500 | - | - | Restricted Stock Units | |
| Pamela Vig | HEAD OF RESEARCH & DEVELOPMENT | Sale of securities on an exchange or to another person at price $ 28.03 per share. | 08 Jan 2024 | 1,408 | 29,905 (0%) | 0% | 28.0 | 39,472 | Common Stock |
| Christopher Peetz | Director, PRESIDENT AND CEO | Sale of securities on an exchange or to another person at price $ 28.03 per share. | 08 Jan 2024 | 5,209 | 110,125 (0%) | 0% | 28.0 | 146,033 | Common Stock |
| Radovich Peter | CHIEF OPERATING OFFICER | Sale of securities on an exchange or to another person at price $ 28.03 per share. | 08 Jan 2024 | 1,408 | 36,485 (0%) | 0% | 28.0 | 39,473 | Common Stock |
| Longpre Lara | CHIEF DEVELOPMENT OFFICER | Sale of securities on an exchange or to another person at price $ 28.04 per share. | 08 Jan 2024 | 1,019 | 105,254 (0%) | 0% | 28.0 | 28,568 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Sale of securities on an exchange or to another person at price $ 28.04 per share. | 06 Jan 2024 | 528 | 722 (0%) | 0% | 28.0 | 14,803 | Common Stock |
| Jolanda Howe | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jan 2024 | 1,250 | 1,250 (0%) | 0% | - | Common Stock | |
| Howe Jolanda | SVP, GLOBAL CONTROLLER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jan 2024 | 1,250 | 1,250 | - | - | Restricted Stock Units | |
| Howe Jolanda | SVP, Global Controller | Sale of securities on an exchange or to another person at price $ 32.40 per share. | 05 Dec 2023 | 2,500 | 0 (0%) | 0% | 32.4 | 81,000 | Common Stock |
| Jolanda Howe | SVP, Global Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.94 per share. | 05 Dec 2023 | 2,500 | 2,500 (0%) | 0% | 2.9 | 7,350 | Common Stock |
| Jolanda Howe | SVP, Global Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2023 | 2,500 | 55,400 | - | - | Stock Option (right to buy) | |
| Peter Radovich | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 22.29 per share. | 10 Nov 2023 | 218 | 37,893 (0%) | 0% | 22.3 | 4,859 | Common Stock |
| Pamela Vig | Head of Research & Development | Grant, award, or other acquisition of securities at price $ 22.29 per share. | 10 Nov 2023 | 527 | 31,313 (0%) | 0% | 22.3 | 11,745 | Common Stock |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 22.29 per share. | 10 Nov 2023 | 434 | 106,273 (0%) | 0% | 22.3 | 9,673 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 28.30 per share. | 09 Nov 2023 | 2,910 | 161,963 (0%) | 0% | 28.3 | 82,353 | Common Stock |
| Michael G. Grey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Sep 2023 | 14,216 | 331,176 | - | - | Stock Option (right to buy) | |
| Michael G. Grey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Sep 2023 | 392 | 345,392 | - | - | Stock Option (right to buy) | |
| Michael G. Grey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.94 per share. | 13 Sep 2023 | 392 | 392 (0%) | 0% | 2.9 | 1,151 | Common Stock |
| Michael G. Grey | Director | Sale of securities on an exchange or to another person at price $ 32.00 per share. | 13 Sep 2023 | 392 | 0 (0%) | 0% | 32 | 12,544 | Common Stock |
| Michael G. Grey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.94 per share. | 13 Sep 2023 | 14,216 | 14,216 (0%) | 0% | 2.9 | 41,738 | Common Stock |
| Michael G. Grey | Director | Sale of securities on an exchange or to another person at price $ 32.00 per share. | 13 Sep 2023 | 14,216 | 0 (0%) | 0% | 32 | 454,912 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 31.02 per share. | 13 Sep 2023 | 2,625 | 159,053 (0%) | 0% | 31.0 | 81,425 | Common Stock |
| Eric H. Bjerkholt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Sep 2023 | 110,000 | 110,000 | - | - | Stock Option (right to buy) | |
| Eric H. Bjerkholt | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 29.65 per share. | 11 Sep 2023 | 10,000 | 10,000 (0%) | 0% | 29.6 | 296,492 | Common Stock |
| Eric H. Bjerkholt | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Sep 2023 | 55,000 | 55,000 | - | - | Restricted Stock Units | |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 30.60 per share. | 11 Sep 2023 | 3,750 | 156,428 (0%) | 0% | 30.6 | 114,764 | Common Stock |
| Patrick J. Heron | Director | Purchase of securities on an exchange or from another person at price $ 30.30 per share. | 11 Sep 2023 | 4,687 | 152,678 (0%) | 0% | 30.3 | 142,027 | Common Stock |
| Patrick J. Heron | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 26.25 per share. | 31 Aug 2023 | 147,991 | 147,991 (0%) | 0% | 26.3 | 3,884,764 | Common Stock |
| Jolanda Howe | SVP, Global Controller | Sale of securities on an exchange or to another person at price $ 26.23 per share. | 25 Aug 2023 | 3,459 | 0 (0%) | 0% | 26.2 | 90,743 | Common Stock |
| Christopher Peetz | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.65 per share. | 03 Jul 2023 | 5,498 | 115,334 (0%) | 0% | 25.6 | 141,005 | Common Stock |
| Peter Radovich | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 25.65 per share. | 03 Jul 2023 | 1,425 | 37,675 (0%) | 0% | 25.6 | 36,546 | Common Stock |
| Pamela Vig | Head of Research & Development | Sale of securities on an exchange or to another person at price $ 25.65 per share. | 03 Jul 2023 | 1,425 | 30,786 (0%) | 0% | 25.6 | 36,546 | Common Stock |
| Lara Longpre | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 25.65 per share. | 03 Jul 2023 | 1,004 | 105,839 (0%) | 0% | 25.6 | 25,749 | Common Stock |
| Jolanda Howe | SVP, Global Controller | Sale of securities on an exchange or to another person at price $ 25.65 per share. | 30 Jun 2023 | 915 | 3,459 (0%) | 0% | 25.6 | 23,467 | Common Stock |
| Jolanda Howe | SVP, Global Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jun 2023 | 1,042 | 4,374 (0%) | 0% | - | Common Stock | |
| Jolanda Howe | SVP, Global Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jun 2023 | 1,563 | 3,332 (0%) | 0% | - | Common Stock | |
| Jolanda Howe | SVP, Global Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jun 2023 | 1,042 | 2,083 | - | - | Restricted Stock Units | |
| Jolanda Howe | SVP, Global Controller | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jun 2023 | 1,563 | 0 | - | - | Performance Restricted Stock Units | |
| Anthony A. Florence | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 2,000,000 | 2,186,243 (8%) | 8% | 0 | Common Stock | |
| Anthony A. Florence | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 11,348 | 11,348 (0%) | 0% | 0 | Common Stock | |
| Anthony A. Florence | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 384 | 384 (0%) | 0% | 0 | Common Stock | |
| Anthony A. Florence | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 0 (0%) | 0% | 0 | Common Stock | |
| Anthony A. Florence | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 30,000 (0%) | 0% | 0 | Common Stock | |
| Sandell D Scott | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 1,455 | 1,455 (0%) | 0% | 0 | Common Stock | |
| Sandell D Scott | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 2,000,000 | 2,186,243 (8%) | 8% | 0 | Common Stock | |
| Sandell D Scott | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 30,000 (0%) | 0% | 0 | Common Stock | |
| Sandell D Scott | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 0 (0%) | 0% | 0 | Common Stock | |
| Sandell D Scott | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 163 | 163 (0%) | 0% | 0 | Common Stock | |
| Sandell D Scott | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 163 | 163 (0%) | 0% | 0 | Common Stock | |
| Sandell D Scott | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 11,348 | 11,348 (0%) | 0% | 0 | Common Stock | |
| Forest Baskett | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 1,548 | 1,548 (0%) | 0% | 0 | Common Stock | |
| Forest Baskett | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 2,000,000 | 2,186,243 (8%) | 8% | 0 | Common Stock | |
| Forest Baskett | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 30,000 (0%) | 0% | 0 | Common Stock | |
| Forest Baskett | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 0 (0%) | 0% | 0 | Common Stock | |
| Paul Walker | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 114 | 114 (0%) | 0% | 0 | Common Stock | |
| Paul Walker | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 2,000,000 | 2,186,243 (8%) | 8% | 0 | Common Stock | |
| Paul Walker | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 30,000 (0%) | 0% | 0 | Common Stock | |
| Paul Walker | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 0 (0%) | 0% | 0 | Common Stock | |
| Ali Behbahani | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 135 | 135 (0%) | 0% | 0 | Common Stock | |
| Ali Behbahani | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 2,000,000 | 2,186,243 (8%) | 8% | 0 | Common Stock | |
| Ali Behbahani | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 30,000 (0%) | 0% | 0 | Common Stock | |
| Ali Behbahani | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 0 (0%) | 0% | 0 | Common Stock | |
| Carmen Chang | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 30,000 (0%) | 0% | 0 | Common Stock | |
| Carmen Chang | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 2,000,000 | 2,186,243 (8%) | 8% | 0 | Common Stock | |
| Carmen Chang | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 135 | 135 (0%) | 0% | 0 | Common Stock | |
| Carmen Chang | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 0 (0%) | 0% | 0 | Common Stock | |
| Mohamad Makhzoumi | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 0 (0%) | 0% | 0 | Common Stock | |
| Mohamad Makhzoumi | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 11,348 | 11,348 (0%) | 0% | 0 | Common Stock | |
| Mohamad Makhzoumi | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 2,000,000 | 2,186,243 (8%) | 8% | 0 | Common Stock | |
| Mohamad Makhzoumi | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 30,000 | 30,000 (0%) | 0% | 0 | Common Stock | |
| Mohamad Makhzoumi | Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 13 Jun 2023 | 153 | 153 (0%) | 0% | 0 | Common Stock | |
| Laura A. Brege | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2023 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Michael G. Grey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2023 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Timothy P. Walbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2023 | 1,417 | 1,417 | - | - | Stock Option (right to buy) | |
| Patrick J. Heron | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2023 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2023 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Laurent Fischer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2023 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| William Carl Fairey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2023 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Lon Cardon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2023 | 7,083 | 7,083 | - | - | Stock Option (right to buy) | |
| Michael G. Grey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.94 per share. | 08 Jun 2023 | 14,608 | 14,608 (0%) | 0% | 2.9 | 42,889 | Common Stock |
| Michael G. Grey | Director | Sale of securities on an exchange or to another person at price $ 29.00 per share. | 08 Jun 2023 | 14,608 | 0 (0%) | 0% | 29 | 423,632 | Common Stock |
| Michael G. Grey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jun 2023 | 14,608 | 345,784 | - | - | Stock Option (right to buy) | |
| Christopher Peetz | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 16.92 per share. | 10 May 2023 | 1,256 | 120,832 (0%) | 0% | 16.9 | 21,256 | Common Stock |
| Peter Radovich | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 16.92 per share. | 10 May 2023 | 968 | 39,100 (0%) | 0% | 16.9 | 16,382 | Common Stock |
| Pamela Vig | Head of Research & Development | Grant, award, or other acquisition of securities at price $ 16.92 per share. | 10 May 2023 | 684 | 32,211 (0%) | 0% | 16.9 | 11,576 | Common Stock |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 16.92 per share. | 10 May 2023 | 684 | 106,843 (0%) | 0% | 16.9 | 11,576 | Common Stock |
| Michael G. Grey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2023 | 14,608 | 360,392 | - | - | Stock Option (right to buy) | |
| Michael G. Grey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.94 per share. | 03 May 2023 | 14,608 | 14,608 (0%) | 0% | 2.9 | 42,889 | Common Stock |
| Michael G. Grey | Director | Sale of securities on an exchange or to another person at price $ 28.00 per share. | 03 May 2023 | 14,608 | 0 (0%) | 0% | 28 | 409,024 | Common Stock |
| Timothy P. Walbert | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Apr 2023 | 34,000 | 34,000 | - | - | Stock Option (right to buy) | |
| Christopher Peetz | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 200,000 | 200,000 | - | - | Stock Option (right to buy) | |
| Christopher Peetz | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 50,000 | 119,576 (0%) | 0% | 0 | Common Stock | |
| Peter Radovich | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 14,440 | 38,132 (0%) | 0% | 0 | Common Stock | |
| Peter Radovich | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 57,750 | 57,750 | - | - | Stock Option (right to buy) | |
| Pamela Vig | Head of Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 9,625 | 31,527 (0%) | 0% | 0 | Common Stock | |
| Pamela Vig | Head of Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 38,500 | 38,500 | - | - | Stock Option (right to buy) | |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 9,625 | 106,159 (0%) | 0% | 0 | Common Stock | |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 38,500 | 38,500 | - | - | Stock Option (right to buy) | |
| Christopher Peetz | Director, CHIEF EXECUTIVE OFFICER | Sale of securities on an exchange or to another person at price $ 20.62 per share. | 09 Jan 2023 | 5,159 | 91,953 (0%) | 0% | 20.6 | 106,390 | Common Stock |
| Peter Radovich | PRESIDENT AND COO | Sale of securities on an exchange or to another person at price $ 20.62 per share. | 09 Jan 2023 | 1,379 | 33,316 (0%) | 0% | 20.6 | 28,438 | Common Stock |
| Pamela Vig | CHIEF SCIENTIFIC OFFICER | Sale of securities on an exchange or to another person at price $ 20.62 per share. | 09 Jan 2023 | 1,379 | 27,312 (0%) | 0% | 20.6 | 28,438 | Common Stock |
| Niall O’Donnell | Director | Sale of securities on an exchange or to another person at price $ 19.69 per share. | 11 Nov 2022 | 93,770 | 1,621,118 (6%) | 0% | 19.7 | 1,846,022 | Common Stock |
| Niall O’Donnell | Director | Sale of securities on an exchange or to another person at price $ 19.60 per share. | 11 Nov 2022 | 32,109 | 1,714,888 (6%) | 0% | 19.6 | 629,423 | Common Stock |
| Niall O’Donnell | Director | Sale of securities on an exchange or to another person at price $ 19.99 per share. | 11 Nov 2022 | 174,121 | 1,746,997 (6%) | 0% | 20.0 | 3,481,410 | Common Stock |
| Christopher Peetz | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 17.04 per share. | 10 Nov 2022 | 49 | 69,576 (0%) | 0% | 17.0 | 835 | Common Stock |
| Peter Radovich | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 17.05 per share. | 10 Nov 2022 | 292 | 23,692 (0%) | 0% | 17.1 | 4,979 | Common Stock |
| Ian Clements | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 17.05 per share. | 10 Nov 2022 | 325 | 30,011 (0%) | 0% | 17.1 | 5,542 | Common Stock |
| Pamela Vig | Head of Research & Development | Grant, award, or other acquisition of securities at price $ 17.05 per share. | 10 Nov 2022 | 660 | 21,902 (0%) | 0% | 17.1 | 11,254 | Common Stock |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 17.05 per share. | 10 Nov 2022 | 82 | 96,534 (0%) | 0% | 17.0 | 1,398 | Common Stock |
| Edward T. Mathers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Laura A. Brege | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Patrick J. Heron | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Saira Ramasastry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 34,000 | 34,000 | - | - | Stock Option (right to buy) | |
| Laurent Fischer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Carol L. Brosgart | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 15,583 | 15,583 | - | - | Stock Option (right to buy) | |
| William C. Fairey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 12,750 | 12,750 | - | - | Stock Option (right to buy) | |
| Niall O’Donnell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2022 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Christopher Peetz | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 13.57 per share. | 10 May 2022 | 1,500 | 69,527 (0%) | 0% | 13.6 | 20,349 | Common STock |
| Peter Radovich | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 13.57 per share. | 10 May 2022 | 1,169 | 23,400 (0%) | 0% | 13.6 | 15,859 | Common Stock |
| Ian Clements | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 13.57 per share. | 10 May 2022 | 1,125 | 29,686 (0%) | 0% | 13.6 | 15,262 | Common Stock |
| Pamela Vig | Head of Research & Development | Grant, award, or other acquisition of securities at price $ 13.57 per share. | 10 May 2022 | 807 | 21,242 (0%) | 0% | 13.6 | 10,948 | Common Stock |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 13.57 per share. | 10 May 2022 | 1,454 | 96,452 (0%) | 0% | 13.6 | 19,725 | Common Stock |
| Christopher Peetz | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 40,000 | 68,027 (0%) | 0% | 0 | Common Stock | |
| Christopher Peetz | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 240,000 | 240,000 | - | - | Stock Option (right to buy) | |
| Peter Radovich | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 10,000 | 22,231 (0%) | 0% | 0 | Common Stock | |
| Peter Radovich | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 60,000 | 60,000 | - | - | Stock Option (right to buy) | |
| Ian Clements | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 10,000 | 28,561 (0%) | 0% | 0 | Common Stock | |
| Ian Clements | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 60,000 | 60,000 | - | - | Stock Option (right to buy) | |
| Pamela Vig | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 10,000 | 20,435 (0%) | 0% | 0 | Common Stock | |
| Pamela Vig | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 60,000 | 60,000 | - | - | Stock Option (right to buy) | |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 60,000 | 60,000 | - | - | Stock Option (right to buy) | |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2022 | 10,000 | 94,998 (0%) | 0% | 0 | Common Stock | |
| Christopher Peetz | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 14.40 per share. | 24 Nov 2021 | 7,000 | 28,027 (0%) | 0% | 14.4 | 100,800 | Common Stock |
| Ian Clements | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 13.90 per share. | 24 Nov 2021 | 750 | 18,561 (0%) | 0% | 13.9 | 10,425 | Common Stock |
| Ian Clements | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 14.40 per share. | 24 Nov 2021 | 700 | 17,811 (0%) | 0% | 14.4 | 10,080 | Common Stock |
| Peter Radovich | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 13.51 per share. | 10 Nov 2021 | 958 | 12,231 (0%) | 0% | 13.5 | 12,947 | Common Stock |
| Ian Clements | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 13.52 per share. | 10 Nov 2021 | 458 | 17,111 (0%) | 0% | 13.5 | 6,190 | Common Stock |
| Pamela Vig | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 13.52 per share. | 10 Nov 2021 | 768 | 10,435 (0%) | 0% | 13.5 | 10,380 | Common Stock |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 13.52 per share. | 10 Nov 2021 | 753 | 84,998 (0%) | 0% | 13.5 | 10,177 | Common Stock |
| Edwin Jonathan Tucker | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 13.51 per share. | 10 Nov 2021 | 70 | 45,838 (0%) | 0% | 13.5 | 946 | Common Stock |
| William C. Fairey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Aug 2021 | 34,000 | 34,000 | - | - | Stock Option (right to buy) | |
| Edward T. Mathers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2021 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Laura Brege | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2021 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Patrick J. Heron | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2021 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Laurent Fischer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2021 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Carol L. Brosgart | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2021 | 34,000 | 34,000 | - | - | Stock Option (right to buy) | |
| Niall O’Donnell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jun 2021 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Christopher Peetz | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 14.62 per share. | 10 May 2021 | 1,453 | 2,824 (0%) | 0% | 14.6 | 21,243 | Common STock |
| Peter Radovich | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 14.62 per share. | 10 May 2021 | 1,006 | 4,512 (0%) | 0% | 14.6 | 14,708 | Common Stock |
| Ian Clements | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 14.62 per share. | 10 May 2021 | 981 | 8,852 (0%) | 0% | 14.6 | 14,342 | Common Stock |
| Pamela Vig | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 14.62 per share. | 10 May 2021 | 699 | 2,906 (0%) | 0% | 14.6 | 10,219 | Common Stock |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 14.62 per share. | 10 May 2021 | 1,259 | 77,081 (0%) | 0% | 14.6 | 18,407 | Common Stock |
| Edwin Jonathan Tucker | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 14.62 per share. | 10 May 2021 | 1,483 | 39,007 (0%) | 0% | 14.6 | 21,681 | Common Stock |
| Edwin Jonathan Tucker | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2021 | 1,082 | 69,751 | - | - | Stock Option (right to buy) | |
| Edwin Jonathan Tucker | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.70 per share. | 05 Mar 2021 | 1,082 | 37,524 (0%) | 0% | 7.7 | 8,331 | Common Stock |
| Christopher Peetz | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 175,000 | 175,000 | - | - | Stock Option (right to buy) | |
| Peter Radovich | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 65,000 | 65,000 | - | - | Stock Option (right to buy) | |
| Ian Clements | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 75,000 | 75,000 | - | - | Stock Option (right to buy) | |
| Pamela Vig | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 65,000 | 65,000 | - | - | Stock Option (right to buy) | |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 65,000 | 65,000 | - | - | Stock Option (right to buy) | |
| Edwin Jonathan Tucker | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2021 | 65,000 | 65,000 | - | - | Stock Option (right to buy) | |
| Edwin Jonathan Tucker | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.70 per share. | 28 Dec 2020 | 4,167 | 36,442 (0%) | 0% | 7.7 | 32,086 | Common Stock |
| Edwin Jonathan Tucker | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2020 | 4,167 | 70,833 | - | - | Stock Option (right to buy) | |
| Christopher Peetz | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 18.60 per share. | 23 Dec 2020 | 2,000 | 201,570 (0%) | 0% | 18.6 | 37,200 | Common Stock |
| Christopher Peetz | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 18.76 per share. | 23 Dec 2020 | 3,000 | 199,570 (0%) | 0% | 18.8 | 56,280 | Common Stock |
| Ian Clements | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 18.65 per share. | 23 Dec 2020 | 1,562 | 7,841 (0%) | 0% | 18.6 | 29,131 | Common Stock |
| Ian Clements | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 18.55 per share. | 23 Dec 2020 | 908 | 6,279 (0%) | 0% | 18.5 | 16,843 | Common Stock |
| Christopher Peetz | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 15.27 per share. | 10 Nov 2020 | 1,371 | 1,371 (0%) | 0% | 15.3 | 20,930 | Common STock |
| Ian Clements | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 15.27 per share. | 10 Nov 2020 | 1,371 | 5,371 (0%) | 0% | 15.3 | 20,930 | Common Stock |
| Pamela Vig | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 15.27 per share. | 10 Nov 2020 | 595 | 2,207 (0%) | 0% | 15.3 | 9,083 | Common Stock |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 15.27 per share. | 10 Nov 2020 | 822 | 75,822 (0%) | 0% | 15.3 | 12,549 | Common Stock |
| Edwin Jonathan Tucker | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 15.27 per share. | 10 Nov 2020 | 1,275 | 32,275 (0%) | 0% | 15.3 | 19,464 | Common Stock |
| Edwin Jonathan Tucker | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2020 | 25,000 | 75,000 | - | - | Stock Option (right to buy) | |
| Edwin Jonathan Tucker | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.70 per share. | 30 Oct 2020 | 25,000 | 31,000 (0%) | 0% | 7.7 | 192,500 | Common Stock |
| Edward T. Mathers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2020 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Laura Brege | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2020 | 14,167 | 14,167 | - | - | Stock Option (right to buy) | |
| Patrick J. Heron | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2020 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Laurent Fischer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2020 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Niall O’Donnell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2020 | 17,000 | 17,000 | - | - | Stock Option (right to buy) | |
| Edwin Jonathan Tucker | Chief Medical Officer | Purchase of securities on an exchange or from another person at price $ 9.91 per share. | 19 Mar 2020 | 2,000 | 3,500 (0%) | 0% | 9.9 | 19,818 | Common Stock |
| Edwin Jonathan Tucker | Chief Medical Officer | Purchase of securities on an exchange or from another person at price $ 11.90 per share. | 19 Mar 2020 | 2,500 | 6,000 (0%) | 0% | 11.9 | 29,740 | Common Stock |
| Christopher Peetz | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 170,000 | 170,000 | - | - | Stock Option (right to buy) | |
| Ian Clements | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 65,000 | 65,000 | - | - | Stock Option (right to buy) | |
| Pamela Vig | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 52,000 | 52,000 | - | - | Stock Option (right to buy) | |
| Lara Longpre | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 52,000 | 52,000 | - | - | Stock Option (right to buy) | |
| Edwin Jonathan Tucker | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2020 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Edwin Jonathan Tucker | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Oct 2019 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Laurent Fischer | None | Purchase of securities on an exchange or from another person at price $ 9.47 per share. | 16 Sep 2019 | 452 | 5,102 (0%) | 0% | 9.5 | 4,280 | Common Stock |
| Laurent Fischer | None | Purchase of securities on an exchange or from another person at price $ 9.37 per share. | 16 Sep 2019 | 1,648 | 6,750 (0%) | 0% | 9.4 | 15,435 | Common Stock |
| Laura Brege | None | Purchase of securities on an exchange or from another person at price $ 11.22 per share. | 10 Sep 2019 | 10,000 | 10,000 (0%) | 0% | 11.2 | 112,200 | Common Stock |
| Lara Longpre | CHIEF DEVELOPMENT OFFICER | Purchase of securities on an exchange or from another person at price $ 10.64 per share. | 10 Sep 2019 | 965 | 105,372 (0%) | 0% | 10.6 | 10,268 | Common Stock |
| Lara Longpre | CHIEF DEVELOPMENT OFFICER | Sale of securities on an exchange or to another person at price $ 20.62 per share. | 10 Sep 2019 | 1,003 | 104,369 (0%) | 0% | 20.6 | 20,684 | Common Stock |
| Laurent Fischer | None | Purchase of securities on an exchange or from another person at price $ 10.54 per share. | 06 Sep 2019 | 1,670 | 3,390 (0%) | 0% | 10.5 | 17,602 | Common Stock |
| Laurent Fischer | None | Purchase of securities on an exchange or from another person at price $ 10.71 per share. | 06 Sep 2019 | 1,720 | 1,720 (0%) | 0% | 10.7 | 18,429 | Common Stock |
| Laurent Fischer | None | Purchase of securities on an exchange or from another person at price $ 10.29 per share. | 06 Sep 2019 | 960 | 4,650 (0%) | 0% | 10.3 | 9,881 | Common Stock |
| Laurent Fischer | None | Purchase of securities on an exchange or from another person at price $ 11.30 per share. | 06 Sep 2019 | 300 | 3,690 (0%) | 0% | 11.3 | 3,390 | Common Stock |
| Christopher Peetz | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 10.91 per share. | 06 Sep 2019 | 4,750 | 192,250 (0%) | 0% | 10.9 | 51,806 | Common Stock |
| Christopher Peetz | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 11.35 per share. | 06 Sep 2019 | 2,320 | 196,570 (0%) | 0% | 11.4 | 26,332 | Common Stock |
| Christopher Peetz | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 10.90 per share. | 06 Sep 2019 | 2,000 | 194,250 (0%) | 0% | 10.9 | 21,800 | Common Stock |
| Ian Clements | SVP Finance & Communications | Purchase of securities on an exchange or from another person at price $ 11.87 per share. | 06 Sep 2019 | 2,199 | 4,000 (0%) | 0% | 11.9 | 26,102 | Common Stock |
| Ian Clements | SVP Finance & Communications | Purchase of securities on an exchange or from another person at price $ 11.07 per share. | 06 Sep 2019 | 1,801 | 1,801 (0%) | 0% | 11.1 | 19,937 | Common Stock |
| Pamela Vig | Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 11.92 per share. | 06 Sep 2019 | 12 | 1,612 (0%) | 0% | 11.9 | 143 | Common Stock |
| Pamela Vig | Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 10.96 per share. | 06 Sep 2019 | 1,600 | 1,600 (0%) | 0% | 11.0 | 17,539 | Common Stock |
| Patrick J. Heron | Director, Ten Percent Owner | 22 Jul 2019 | 3,116,912 | 3,116,912 (13%) | 13% | 0 | Common Stock | ||
| Patrick J. Heron | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 450,000 | 3,566,912 (15%) | 1% | 15 | 6,750,000 | Common Stock |
| Patrick J. Heron | Director, Ten Percent Owner | 22 Jul 2019 | 24,935,300 | 0 | - | - | Series A Preferred Stock | ||
| Niall O’Donnell | None | 22 Jul 2019 | 1,496,118 | 1,621,118 (7%) | 6% | 0 | Common Stock | ||
| Niall O’Donnell | None | 22 Jul 2019 | 11,968,944 | 0 | - | - | Series A Preferred Stock | ||
| Niall O’Donnell | None | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 300,000 | 1,921,118 (8%) | 1% | 15 | 4,500,000 | Common Stock |
| Anthony A. Florence | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 450,000 | 4,186,243 (16%) | 1% | 15 | 6,750,000 | Common Stock |
| Anthony A. Florence | Ten Percent Owner | 22 Jul 2019 | 3,736,243 | 3,736,243 (14%) | 16% | - | Common Stock | ||
| Anthony A. Florence | Ten Percent Owner | 22 Jul 2019 | 29,889,945 | 0 | - | - | Series A Preferred Stock | ||
| Michael G. Grey | Director, Executive Chairman | 22 Jul 2019 | 63,585 | 0 | - | - | Series A Prefered Stock | ||
| Michael G. Grey | Director, Executive Chairman | 22 Jul 2019 | 7,948 | 289,198 (1%) | 0% | - | Common Stock | ||
| Peter J. Barris | Ten Percent Owner | 22 Jul 2019 | 3,736,243 | 3,736,243 (14%) | 16% | - | Common Stock | ||
| Peter J. Barris | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 450,000 | 4,186,243 (16%) | 1% | 15 | 6,750,000 | Common Stock |
| Peter J. Barris | Ten Percent Owner | 22 Jul 2019 | 29,889,945 | 0 | - | - | Series A Preferred Stock | ||
| David M. Mott | Ten Percent Owner | 22 Jul 2019 | 3,736,243 | 3,736,243 (14%) | 16% | - | Common Stock | ||
| David M. Mott | Ten Percent Owner | 22 Jul 2019 | 29,889,945 | 0 | - | - | Series A Preferred Stock | ||
| David M. Mott | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 450,000 | 4,186,243 (16%) | 1% | 15 | 6,750,000 | Common Stock |
| Sandell D Scott | Ten Percent Owner | 22 Jul 2019 | 3,736,243 | 3,736,243 (14%) | 16% | - | Common Stock | ||
| Sandell D Scott | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 450,000 | 4,186,243 (16%) | 1% | 15 | 6,750,000 | Common Stock |
| Sandell D Scott | Ten Percent Owner | 22 Jul 2019 | 29,889,945 | 0 | - | - | Series A Preferred Stock | ||
| Forest Baskett | Ten Percent Owner | 22 Jul 2019 | 3,736,243 | 3,736,243 (14%) | 16% | - | Common Stock | ||
| Forest Baskett | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 450,000 | 4,186,243 (16%) | 1% | 15 | 6,750,000 | Common Stock |
| Forest Baskett | Ten Percent Owner | 22 Jul 2019 | 29,889,945 | 0 | - | - | Series A Preferred Stock | ||
| Joshua Makower | Ten Percent Owner | 22 Jul 2019 | 3,736,243 | 3,736,243 (14%) | 16% | - | Common Stock | ||
| Joshua Makower | Ten Percent Owner | 22 Jul 2019 | 29,889,945 | 0 | - | - | Series A Preferred Stock | ||
| Joshua Makower | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 450,000 | 4,186,243 (16%) | 1% | 15 | 6,750,000 | Common Stock |
| Flynn E James | Other, Possible Member of 10% Group | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 166,000 | 166,000 (0%) | 0% | 15 | 2,490,000 | Common Stock |
| Flynn E James | Other, Possible Member of 10% Group | 22 Jul 2019 | 12,467,650 | 0 | - | - | Series A Preferred Stock | ||
| Flynn E James | Other, Possible Member of 10% Group | 22 Jul 2019 | 12,467,650 | 0 | - | - | Series A Preferred Stock | ||
| Flynn E James | Other, Possible Member of 10% Group | 22 Jul 2019 | 1,558,456 | 1,558,456 (6%) | 6% | - | Common Stock | ||
| Flynn E James | Other, Possible Member of 10% Group | 22 Jul 2019 | 1,558,456 | 1,558,456 (6%) | 6% | - | Common Stock | ||
| Flynn E James | Other, Possible Member of 10% Group | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 166,000 | 1,724,456 (6%) | 0% | 15 | 2,490,000 | Common Stock |
| Paul Walker | Ten Percent Owner | 22 Jul 2019 | 3,736,243 | 3,736,243 (14%) | 16% | - | Common Stock | ||
| Paul Walker | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 450,000 | 4,186,243 (16%) | 1% | 15 | 6,750,000 | Common Stock |
| Paul Walker | Ten Percent Owner | 22 Jul 2019 | 29,889,945 | 0 | - | - | Series A Preferred Stock | ||
| Ali Behbahani | Ten Percent Owner | 22 Jul 2019 | 29,889,945 | 0 | - | - | Series A Preferred Stock | ||
| Ali Behbahani | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 450,000 | 4,186,243 (16%) | 1% | 15 | 6,750,000 | Common Stock |
| Ali Behbahani | Ten Percent Owner | 22 Jul 2019 | 3,736,243 | 3,736,243 (14%) | 16% | - | Common Stock | ||
| Peter Sonsini | Ten Percent Owner | 22 Jul 2019 | 3,736,243 | 3,736,243 (14%) | 16% | - | Common Stock | ||
| Peter Sonsini | Ten Percent Owner | 22 Jul 2019 | 29,889,945 | 0 | - | - | Series A Preferred Stock | ||
| Peter Sonsini | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 450,000 | 4,186,243 (16%) | 1% | 15 | 6,750,000 | Common Stock |
| Carmen Chang | Ten Percent Owner | 22 Jul 2019 | 3,736,243 | 3,736,243 (14%) | 16% | - | Common Stock | ||
| Carmen Chang | Ten Percent Owner | 22 Jul 2019 | 29,889,945 | 0 | - | - | Series A Preferred Stock | ||
| Carmen Chang | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 15.00 per share. | 22 Jul 2019 | 450,000 | 4,186,243 (16%) | 1% | 15 | 6,750,000 | Common Stock |
| Laura Brege | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jul 2019 | 17,000 | 17,000 | - | - | Stock Option (right to buy) |