930.1K XNAS Volume
XNAS 20 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Kathleen Ford | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 1,817 | 21,367 (0%) | 0% | 7.9 | 14,303 | Common Stock |
| Teresa Brophy Bair | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 2,437 | 112,792 (0%) | 0% | 7.9 | 19,184 | Common Stock |
| Teresa Brophy Bair | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 4,844 | 107,948 (0%) | 0% | 7.9 | 38,131 | Common Stock |
| Thomas Doyle | SVP, Finance & Accounting | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 1,122 | 88,193 (0%) | 0% | 7.9 | 8,832 | Common Stock |
| Thomas Doyle | SVP, Finance & Accounting | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 699 | 89,315 (0%) | 0% | 7.9 | 5,502 | Common Stock |
| Thomas Doyle | SVP, Finance & Accounting | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 2,241 | 90,901 (0%) | 0% | 7.9 | 17,641 | Common Stock |
| Thomas Doyle | SVP, Finance & Accounting | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 887 | 90,014 (0%) | 0% | 7.9 | 6,982 | Common Stock |
| Brian T. Powl | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 1,583 | 59,667 (0%) | 0% | 7.9 | 12,461 | Common Stock |
| Mollie Leoni | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 1,353 | 89,610 (0%) | 0% | 7.9 | 10,651 | Common Stock |
| Mollie Leoni | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 2,253 | 90,963 (0%) | 0% | 7.9 | 17,735 | Common Stock |
| Mollie Leoni | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 541 | 88,253 (0%) | 0% | 7.9 | 4,259 | Common Stock |
| Mollie Leoni | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 816 | 88,794 (0%) | 0% | 7.9 | 6,423 | Common Stock |
| Francis Burrows | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 846 | 22,025 (0%) | 0% | 7.9 | 6,660 | Common Stock |
| Francis Burrows | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 7.87 per share. | 28 Jan 2025 | 1,320 | 20,705 (0%) | 0% | 7.9 | 10,391 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 625,000 | 625,000 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 185,000 | 185,000 | - | - | Option to purchase common stock | |
| Teresa Brophy Bair | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 46,250 | 115,229 (0%) | 0% | 0 | Common Stock | |
| Teresa Brophy Bair | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 92,500 | 92,500 | - | - | Option to purchase common stock | |
| Thomas Doyle | SVP, Finance & Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 21,250 | 71,892 (0%) | 0% | 0 | Common Stock | |
| Thomas Doyle | SVP, Finance & Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 21,250 | 93,142 (0%) | 0% | 0 | Common Stock | |
| Thomas Doyle | SVP, Finance & Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 42,500 | 42,500 | - | - | Option to purchase common stock | |
| Brian T. Powl | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 46,250 | 61,250 (0%) | 0% | 0 | Common Stock | |
| Brian T. Powl | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 92,500 | 92,500 | - | - | Option to purchase common stock | |
| Mollie Leoni | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 92,500 | 92,500 | - | - | Option to purchase common stock | |
| Mollie Leoni | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 46,250 | 93,216 (0%) | 0% | 0 | Common Stock | |
| Francis Burrows | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 185,000 | 185,000 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 16.03 per share. | 18 Nov 2024 | 526 | 23,184 (0%) | 0% | 16.0 | 8,434 | Common Stock |
| Michael J. Vasconcelles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Sep 2024 | 17,333 | 17,333 | - | - | Option to purchase common stock | |
| Michael J. Vasconcelles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Sep 2024 | 52,000 | 52,000 | - | - | Option to purchase common stock | |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Faheem Hasnain | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Mary T. Szela | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Thomas R. Malley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Helen Collins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Diane L. Parks | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Teresa Brophy Bair | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 22.15 per share. | 20 May 2024 | 2,615 | 68,979 (0%) | 0% | 22.1 | 57,916 | Common Stock |
| Thomas Doyle | SVP, Finance & Accounting | Sale of securities on an exchange or to another person at price $ 17.80 per share. | 29 Jan 2024 | 594 | 49,817 (0%) | 0% | 17.8 | 10,573 | Common Stock |
| Ford Kathleen | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 17.80 per share. | 29 Jan 2024 | 1,496 | 21,602 (0%) | 0% | 17.8 | 26,630 | Common Stock |
| Stephen Dale | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 21.55 per share. | 29 Jan 2024 | 4,825 | 38,817 (0%) | 0% | 21.6 | 103,980 | Common Stock |
| Thomas Doyle | SVP, Finance & Accounting | Sale of securities on an exchange or to another person at price $ 17.80 per share. | 29 Jan 2024 | 963 | 48,093 (0%) | 0% | 17.8 | 17,142 | Common Stock |
| Dale Stephen | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 17.80 per share. | 29 Jan 2024 | 2,758 | 43,642 (0%) | 0% | 17.8 | 49,094 | Common Stock |
| Doyle Thomas | SVP, Finance & Accounting | Sale of securities on an exchange or to another person at price $ 17.80 per share. | 29 Jan 2024 | 761 | 49,056 (0%) | 0% | 17.8 | 13,546 | Common Stock |
| Stephen Dale | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 17.80 per share. | 29 Jan 2024 | 4,400 | 46,400 (0%) | 0% | 17.8 | 78,322 | Common Stock |
| Teresa Brophy Bair | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 17.80 per share. | 29 Jan 2024 | 2,053 | 68,979 (0%) | 0% | 17.8 | 36,544 | Common Stock |
| E. Troy Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.23 per share. | 24 Jan 2024 | 84,107 | 559 (0%) | 0% | 20.2 | 1,701,485 | Common Stock |
| Wilson E. Troy | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.23 per share. | 24 Jan 2024 | 6,945 | 559 (0%) | 0% | 20.2 | 140,497 | Common Stock |
| E. Troy Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 24 Jan 2024 | 84,107 | 84,666 (0%) | 0% | 6.1 | 517,258 | Common Stock |
| Wilson E. Troy | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.80 per share. | 24 Jan 2024 | 6,945 | 7,504 (0%) | 0% | 4.8 | 33,336 | Common Stock |
| Wilson Troy E. | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 560,000 | 560,000 | - | - | Option to purchase common stock | |
| Bair Brophy Teresa | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 92,500 | 92,500 | - | - | Option to purchase common stock | |
| Dale Stephen | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 185,000 | 185,000 | - | - | Option to purchase common stock | |
| Doyle Thomas | SVP, Finance & Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 42,500 | 42,500 | - | - | Option to purchase common stock | |
| Ford Kathleen | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 185,000 | 185,000 | - | - | Option to purchase common stock | |
| Bair Teresa Brophy | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 46,250 | 71,032 (0%) | 0% | 0 | Common Stock | |
| Doyle Thomas | SVP, Finance & Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 21,250 | 50,411 (0%) | 0% | 0 | Common Stock | |
| Brian T. Powl | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 15,000 | 15,000 (0%) | 0% | 0 | Common Stock | |
| Brian T. Powl | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 30,000 | 30,000 | - | - | Option to purchase common stock | |
| Troy Wilson E. | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 07 Dec 2023 | 1,000 | 279,194 (0%) | 0% | 0 | Common Stock | |
| E. Wilson Troy | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 07 Dec 2023 | 2,000 | 559 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Malley | Director | Purchase of securities on an exchange or from another person at price $ 11.50 per share. | 16 Jun 2023 | 50,000 | 139,557 (0%) | 0% | 11.5 | 575,000 | Common stock |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 02 Jun 2023 | 8,394 | 0 (0%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 02 Jun 2023 | 27,966 | 2,559 (0%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 02 Jun 2023 | 300,000 | 300,000 (0%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 02 Jun 2023 | 300,000 | 280,194 (0%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 02 Jun 2023 | 300,000 | 580,194 (1%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 02 Jun 2023 | 212,500 | 880,194 (1%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 02 Jun 2023 | 8,394 | 1,134,012 (2%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 02 Jun 2023 | 41,318 | 1,092,694 (2%) | 0% | 0 | Common Stock | |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2023 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Faheem Hasnain | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2023 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Mary T. Szela | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2023 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Thomas R. Malley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2023 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Helen Collins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2023 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Diane L. Parks | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2023 | 26,000 | 26,000 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 185,000 | 185,000 | - | - | Option to purchase common stock | |
| Teresa Brophy Bair | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 23,125 | 23,125 (0%) | 0% | 0 | Common Stock | |
| Teresa Brophy Bair | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 138,750 | 138,750 | - | - | Option to purchase common stock | |
| Stephen Dale | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 185,000 | 185,000 | - | - | Option to purchase common stock | |
| Stephen Dale | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 23,125 | 50,800 (0%) | 0% | 0 | Common Stock | |
| Thomas Doyle | SVP, Finance & Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 63,750 | 63,750 | - | - | Option to purchase common stock | |
| Thomas Doyle | SVP, Finance & Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 10,625 | 27,466 (0%) | 0% | 0 | Common Stock | |
| Kathleen Ford | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 13.89 per share. | 27 Jan 2023 | 1,821 | 21,214 (0%) | 0% | 13.9 | 25,294 | Common Stock |
| Kirsten Flowers | CCO & Chief Strategy Officer | Sale of securities on an exchange or to another person at price $ 13.89 per share. | 27 Jan 2023 | 1,906 | 20,605 (0%) | 0% | 13.9 | 26,474 | Common Stock |
| Stephen Dale | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 13.87 per share. | 27 Jan 2023 | 4,840 | 27,675 (0%) | 0% | 13.9 | 67,124 | Common Stock |
| Stephen Dale | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 13.89 per share. | 27 Jan 2023 | 4,385 | 32,515 (0%) | 0% | 13.9 | 60,909 | Common Stock |
| Thomas Doyle | SVP, Finance & Accounting | Sale of securities on an exchange or to another person at price $ 13.89 per share. | 27 Jan 2023 | 866 | 16,841 (0%) | 0% | 13.9 | 12,029 | Common Stock |
| Thomas Doyle | SVP, Finance & Accounting | Sale of securities on an exchange or to another person at price $ 13.89 per share. | 27 Jan 2023 | 682 | 17,707 (0%) | 0% | 13.9 | 9,473 | Common Stock |
| Teresa Brophy Bair | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 15.22 per share. | 17 Nov 2022 | 2,100 | 0 (0%) | 0% | 15.2 | 31,965 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jul 2022 | 560,000 | 560,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 14 Jul 2022 | 11,985 | 30,525 (0%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 14 Jul 2022 | 1,084,300 | 1,125,618 (2%) | 2% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 14 Jul 2022 | 1,084,300 | 8,394 (0%) | 2% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 14 Jul 2022 | 41,318 | 1,092,694 (2%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 14 Jul 2022 | 17,708 | 1,134,012 (2%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 14 Jul 2022 | 468,297 | 1,151,720 (2%) | 1% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 14 Jul 2022 | 41,318 | 41,318 (0%) | 0% | 0 | Common Stock | |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Faheem Hasnain | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Mary T. Szela | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Thomas R. Malley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Steven H. Stein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Helen Collins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Diane L. Parks | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jun 2022 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Thomas Doyle | SVP, Finance & Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2022 | 8,390 | 15,000 (0%) | 0% | 0 | Common Stock | |
| Thomas Doyle | SVP, Finance & Accounting | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2022 | 39,281 | 39,281 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2022 | 495,000 | 495,000 | - | - | Option to purchase common stock | |
| Marc Grasso | CFO, CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2022 | 21,900 | 21,900 (0%) | 0% | 0 | Common Stock | |
| Marc Grasso | CFO, CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2022 | 131,000 | 131,000 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2022 | 171,000 | 171,000 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2022 | 21,900 | 23,035 (0%) | 0% | 0 | Common Stock | |
| Kirsten Flowers | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2022 | 21,900 | 22,511 (0%) | 0% | 0 | Common Stock | |
| Kirsten Flowers | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2022 | 171,000 | 171,000 | - | - | Option to purchase common stock | |
| Stephen Dale | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2022 | 261,000 | 261,000 | - | - | Option to purchase common stock | |
| Stephen Dale | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2022 | 36,900 | 36,900 (0%) | 0% | 0 | Common Stock | |
| Helen Collins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jul 2021 | 19,166 | 19,166 | - | - | Option to purchase common stock | |
| Helen Collins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jul 2021 | 46,000 | 46,000 | - | - | Option to purchase common stock | |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Faheem Hasnain | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Mary T. Szela | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Thomas R. Malley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Robert E. Hoffman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Steven H. Stein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Diane L. Parks | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2021 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2021 | 46,000 | 46,000 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 29.43 per share. | 15 Mar 2021 | 6,250 | 0 (0%) | 0% | 29.4 | 183,951 | Common Stock |
| Kathleen Ford | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2021 | 6,250 | 215,625 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.43 per share. | 15 Mar 2021 | 6,250 | 6,250 (0%) | 0% | 19.4 | 121,438 | Common Stock |
| Marc Grasso | CFO, CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2021 | 175,000 | 175,000 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2021 | 140,000 | 140,000 | - | - | Option to purchase common stock | |
| James Basta | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2021 | 125,000 | 125,000 | - | - | Option to purchase common stock | |
| Kirsten Flowers | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2021 | 125,000 | 125,000 | - | - | Option to purchase common stock | |
| Stephen Dale | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jan 2021 | 100,000 | 100,000 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.43 per share. | 15 Dec 2020 | 6,250 | 6,250 (0%) | 0% | 19.4 | 121,438 | Common Stock |
| Kathleen Ford | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.60 per share. | 15 Dec 2020 | 3,125 | 0 (0%) | 0% | 40.6 | 126,886 | Common Stock |
| Kathleen Ford | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2020 | 9,375 | 221,875 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.43 per share. | 15 Dec 2020 | 3,125 | 3,125 (0%) | 0% | 19.4 | 60,719 | Common Stock |
| Kathleen Ford | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 40.60 per share. | 15 Dec 2020 | 6,250 | 0 (0%) | 0% | 40.6 | 253,781 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2020 | 11,855 | 90,210 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 01 Dec 2020 | 11,855 | 39,951 (0%) | 0% | 6.1 | 72,908 | Common Stock |
| Kathleen Ford | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 39.43 per share. | 10 Nov 2020 | 6,250 | 0 (0%) | 0% | 39.4 | 246,438 | Common Stock |
| Kathleen Ford | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Nov 2020 | 6,250 | 231,250 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.43 per share. | 10 Nov 2020 | 6,250 | 6,250 (0%) | 0% | 19.4 | 121,438 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.00 per share. | 06 Oct 2020 | 99,900 | 106,736 (0%) | 0% | 32 | 3,196,800 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2020 | 50,370 | 102,065 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2020 | 4,586 | 152,435 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 34.00 per share. | 06 Oct 2020 | 50,370 | 28,096 (0%) | 0% | 34 | 1,712,580 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 06 Oct 2020 | 50,370 | 78,466 (0%) | 0% | 6.2 | 309,776 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 34.00 per share. | 06 Oct 2020 | 4,586 | 28,096 (0%) | 0% | 34 | 155,924 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 06 Oct 2020 | 4,586 | 32,682 (0%) | 0% | 6.2 | 28,204 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 34.00 per share. | 06 Oct 2020 | 106,736 | 0 (0%) | 0% | 34 | 3,629,024 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.00 per share. | 06 Oct 2020 | 100 | 206,636 (0%) | 0% | 32 | 3,200 | Common Stock |
| Marc Grasso | CFO, CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2020 | 7,898 | 105,000 | - | - | Option to purchase common stock | |
| Marc Grasso | CFO, CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2020 | 2,102 | 247,898 | - | - | Option to purchase common stock | |
| Marc Grasso | CFO, CBO | Sale of securities on an exchange or to another person at price $ 29.00 per share. | 14 Sep 2020 | 10,000 | 0 (0%) | 0% | 29 | 290,000 | Common Stock |
| Marc Grasso | CFO, CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.00 per share. | 14 Sep 2020 | 2,102 | 10,000 (0%) | 0% | 29 | 60,958 | Common Stock |
| Marc Grasso | CFO, CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.00 per share. | 14 Sep 2020 | 7,898 | 7,898 (0%) | 0% | 29 | 229,042 | Common Stock |
| Kathleen Ford | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.43 per share. | 14 Sep 2020 | 6,250 | 6,250 (0%) | 0% | 19.4 | 121,438 | Common Stock |
| Kathleen Ford | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2020 | 6,250 | 237,500 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2020 | 6,250 | 243,750 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 29.43 per share. | 14 Sep 2020 | 6,250 | 0 (0%) | 0% | 29.4 | 183,938 | Common Stock |
| Kathleen Ford | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.43 per share. | 14 Sep 2020 | 6,250 | 6,250 (0%) | 0% | 19.4 | 121,438 | Common Stock |
| Kathleen Ford | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 29.43 per share. | 14 Sep 2020 | 6,250 | 0 (0%) | 0% | 29.4 | 183,938 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 11 Sep 2020 | 17,926 | 46,022 (0%) | 0% | 6.2 | 110,245 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2020 | 17,926 | 157,021 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 28.82 per share. | 11 Sep 2020 | 98,490 | 206,736 (0%) | 0% | 28.8 | 2,838,876 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 28.00 per share. | 11 Sep 2020 | 485 | 305,226 (0%) | 0% | 28 | 13,580 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 28.00 per share. | 11 Sep 2020 | 17,926 | 28,096 (0%) | 0% | 28 | 501,928 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 28.00 per share. | 08 Sep 2020 | 1,025 | 305,711 (0%) | 0% | 28 | 28,700 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 08 Sep 2020 | 37,030 | 65,126 (0%) | 0% | 6.2 | 227,735 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 28.00 per share. | 08 Sep 2020 | 37,030 | 28,096 (0%) | 0% | 28 | 1,036,840 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 26.00 per share. | 08 Sep 2020 | 50,000 | 306,736 (0%) | 0% | 26 | 1,300,000 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2020 | 37,030 | 174,947 | - | - | Option to purchase common stock | |
| Marc Grasso | CFO, CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2020 | 10,000 | 112,898 | - | - | Option to purchase common stock | |
| Marc Grasso | CFO, CBO | Sale of securities on an exchange or to another person at price $ 26.00 per share. | 08 Sep 2020 | 10,000 | 0 (0%) | 0% | 26 | 260,000 | Common Stock |
| Marc Grasso | CFO, CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.47 per share. | 08 Sep 2020 | 10,000 | 10,000 (0%) | 0% | 15.5 | 154,700 | Common Stock |
| Marc Grasso | CFO, CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Aug 2020 | 10,000 | 122,898 | - | - | Option to purchase common stock | |
| Marc Grasso | CFO, CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.47 per share. | 25 Aug 2020 | 10,000 | 10,000 (0%) | 0% | 15.5 | 154,700 | Common Stock |
| Marc Grasso | CFO, CBO | Sale of securities on an exchange or to another person at price $ 23.00 per share. | 25 Aug 2020 | 10,000 | 0 (0%) | 0% | 23 | 230,000 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.80 per share. | 24 Aug 2020 | 6,568 | 34,664 (0%) | 0% | 4.8 | 31,526 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Aug 2020 | 215 | 6,945 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Aug 2020 | 22,838 | 211,977 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Aug 2020 | 6,568 | 7,160 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 22.37 per share. | 24 Aug 2020 | 23,053 | 28,096 (0%) | 0% | 22.4 | 515,788 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.80 per share. | 24 Aug 2020 | 215 | 51,149 (0%) | 0% | 4.8 | 1,032 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 24 Aug 2020 | 22,838 | 50,934 (0%) | 0% | 6.2 | 140,454 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 22.04 per share. | 24 Aug 2020 | 6,568 | 28,096 (0%) | 0% | 22.0 | 144,770 | Common Stock |
| Stephen Dale | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Aug 2020 | 200,000 | 200,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 22.00 per share. | 17 Aug 2020 | 521 | 28,096 (0%) | 0% | 22 | 11,462 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2020 | 11,913 | 13,728 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2020 | 521 | 25,641 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2020 | 12,901 | 26,162 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 22.09 per share. | 17 Aug 2020 | 11,913 | 28,096 (0%) | 0% | 22.1 | 263,196 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.80 per share. | 17 Aug 2020 | 11,913 | 40,009 (0%) | 0% | 4.8 | 57,182 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.80 per share. | 17 Aug 2020 | 521 | 28,617 (0%) | 0% | 4.8 | 2,501 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 22.00 per share. | 17 Aug 2020 | 12,901 | 28,096 (0%) | 0% | 22.0 | 283,868 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.80 per share. | 17 Aug 2020 | 12,901 | 40,997 (0%) | 0% | 4.8 | 61,925 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 22.00 per share. | 17 Aug 2020 | 50,000 | 356,736 (0%) | 0% | 22 | 1,100,000 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Aug 2020 | 26,041 | 1,795,017 (3%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Aug 2020 | 26,041 | 28,096 (0%) | 0% | 0 | Common Stock | |
| Marc Grasso | CFO, CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2020 | 7,102 | 132,898 | - | - | Option to purchase common stock | |
| Marc Grasso | CFO, CBO | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 07 Aug 2020 | 10,000 | 0 (0%) | 0% | 20 | 200,000 | Common Stock |
| Marc Grasso | CFO, CBO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.47 per share. | 07 Aug 2020 | 7,102 | 10,000 (0%) | 0% | 15.5 | 109,868 | Common Stock |
| Faheem Hasnain | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2020 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Mary T. Szela | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2020 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Thomas R. Malley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2020 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Robert E. Hoffman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2020 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Steven H. Stein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2020 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| Diane L. Parks | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2020 | 23,000 | 23,000 | - | - | Option to purchase common stock | |
| James Basta | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Mar 2020 | 25,000 | 25,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.80 per share. | 11 Feb 2020 | 26,911 | 54,137 (0%) | 0% | 4.8 | 129,173 | Common stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Feb 2020 | 26,911 | 39,063 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Feb 2020 | 1,185 | 234,815 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 11 Feb 2020 | 1,185 | 27,226 (0%) | 0% | 6.2 | 7,288 | Common stock |
| Bridget A. Martell | Acting Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2020 | 50,000 | 50,000 | - | - | Option to purchase common stock | |
| Bridget A. Martell | Acting Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2020 | 50,000 | 50,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2020 | 393,950 | 393,950 | - | - | Option to purchase common stock | |
| Marc Grasso | CFO, CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2020 | 111,723 | 111,723 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2020 | 45,393 | 45,393 | - | - | Option to purchase common stock | |
| Kirsten Flowers | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2020 | 250,000 | 250,000 | - | - | Option to purchase common stock | |
| James Basta | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Nov 2019 | 175,000 | 175,000 | - | - | Option to purchase common stock | |
| Diane L. Parks | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Oct 2019 | 8,666 | 8,666 | - | - | Option to purchase common stock | |
| Diane L. Parks | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Oct 2019 | 30,000 | 30,000 | - | - | Option to purchase common stock | |
| Kathleen Ford | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Aug 2019 | 250,000 | 250,000 | - | - | Option to purchase common stock | |
| Antonio Gualberto | Head of Development & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.15 per share. | 10 Jul 2019 | 18,000 | 357,973 (0%) | 0% | 6.2 | 110,700 | Common Stock |
| Antonio Gualberto | Head of Development & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2019 | 18,000 | 151,000 | - | - | Option to purchase common stock | |
| Antonio Gualberto | Head of Development & CMO | Sale of securities on an exchange or to another person at price $ 21.11 per share. | 10 Jul 2019 | 18,000 | 339,973 (0%) | 0% | 21.1 | 379,903 | Common Stock |
| Faheem Hasnain | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2019 | 13,000 | 13,000 | - | - | Option to purchase common stock | |
| Mary T. Szela | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2019 | 13,000 | 13,000 | - | - | Option to purchase common stock | |
| Thomas R. Malley | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2019 | 13,000 | 13,000 | - | - | Option to purchase common stock | |
| Robert E. Hoffman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2019 | 13,000 | 13,000 | - | - | Option to purchase common stock | |
| Steven H. Stein | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jun 2019 | 13,000 | 13,000 | - | - | Option to purchase common stock | |
| Annette North | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2019 | 100,000 | 100,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2019 | 220,000 | 220,000 | - | - | Option to purchase common stock | |
| Antonio Gualberto | Head of Development & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2019 | 140,000 | 140,000 | - | - | Option to purchase common stock | |
| Pingda Ren | SVP Chemistry&Pharma Sciences | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2019 | 75,000 | 75,000 | - | - | Option to purchase common stock | |
| John Farnam | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2019 | 125,000 | 125,000 | - | - | Option to purchase common stock | |
| Marc Grasso | CFO, CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jan 2019 | 140,000 | 140,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2018 | 32,985 | 1,768,976 (4%) | 0% | 0 | Common Stock | |
| Troy E. Wilson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2018 | 32,985 | 26,041 (0%) | 0% | 0 | Common Stock | |
| Mary T. Szela | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Nov 2018 | 30,000 | 30,000 | - | - | Option to purchase common stock | |
| Mary T. Szela | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Nov 2018 | 7,583 | 7,583 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Nov 2018 | 26,041 | 65,974 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.80 per share. | 06 Nov 2018 | 26,041 | 59,026 (0%) | 0% | 4.8 | 124,997 | Common Stock |
| Marc Grasso | CFO, CBO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Aug 2018 | 250,000 | 250,000 | - | - | Option to purchase common stock | |
| John Farnam | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jul 2018 | 115,000 | 115,000 | - | - | Option to purchase common stock | |
| Faheem Hasnain | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 13,000 | 13,000 | - | - | Option to purchase common stock | |
| Thomas R. Malley | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 13,000 | 13,000 | - | - | Option to purchase common stock | |
| Robert E. Hoffman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 13,000 | 13,000 | - | - | Option to purchase common stock | |
| Steven H. Stein | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2018 | 13,000 | 13,000 | - | - | Option to purchase common stock | |
| Heidi Henson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 81,000 | 81,000 | - | - | Option to purchase common stock | |
| Annette North | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 70,000 | 70,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 275,000 | 275,000 | - | - | Option to purchase common stock | |
| Yi Liu | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 43,000 | 43,000 | - | - | Option to purchase common stock | |
| Antonio Gualberto | Head of Development & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 100,000 | 100,000 | - | - | Option to purchase common stock | |
| Pingda Ren | SVP Chemistry&Pharma Sciences | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jan 2018 | 43,000 | 43,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.80 per share. | 22 Aug 2017 | 27,985 | 32,985 (0%) | 0% | 4.8 | 134,328 | Common Stock |
| Troy E. Wilson | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Aug 2017 | 27,985 | 92,015 | - | - | Option to purchase common stock | |
| Faheem Hasnain | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2017 | 10,000 | 10,000 | - | - | Option to purchase common stock | |
| Thomas R. Malley | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2017 | 10,000 | 10,000 | - | - | Option to purchase common stock | |
| Robert E. Hoffman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2017 | 10,000 | 10,000 | - | - | Option to purchase common stock | |
| Steven H. Stein | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2017 | 10,000 | 10,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Apr 2017 | 5,000 | 120,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.80 per share. | 21 Apr 2017 | 5,000 | 5,000 (0%) | 0% | 4.8 | 24,000 | Common Stock |
| Heidi Henson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2017 | 100,000 | 100,000 | - | - | Option to purchase common stock | |
| Annette North | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2017 | 72,000 | 72,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2017 | 236,000 | 236,000 | - | - | Option to purchase common stock | |
| Yi Liu | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2017 | 63,000 | 63,000 | - | - | Option to purchase common stock | |
| Antonio Gualberto | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2017 | 169,000 | 169,000 | - | - | Option to purchase common stock | |
| Pingda Ren | SVP-Chemistry&Pharma Sciences | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2017 | 55,000 | 55,000 | - | - | Option to purchase common stock | |
| Steven H. Stein | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2017 | 30,000 | 30,000 | - | - | Option to purchase common stock | |
| Steven H. Stein | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2017 | 3,333 | 3,333 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2016 | 1,000 | 1,735,991 | - | - | Common Stock | |
| Robert E. Hoffman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2016 | 10,000 | 10,000 | - | - | Option to purchase common stock | |
| Faheem Hasnain | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2016 | 10,000 | 10,000 | - | - | Option to purchase common stock | |
| Thomas R. Malley | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2016 | 10,000 | 10,000 | - | - | Option to purchase common stock | |
| Heidi Henson | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2016 | 80,000 | 80,000 | - | - | Option to purchase common stock | |
| Annette North | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2016 | 80,000 | 80,000 | - | - | Option to purchase common stock | |
| Troy E. Wilson | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2016 | 125,000 | 125,000 | - | - | Option to purchase common stock | |
| Yi Liu | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2016 | 50,000 | 50,000 | - | - | Option to purchase common stock | |
| Antonio Gualberto | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2016 | 75,000 | 75,000 | - | - | Option to purchase common stock | |
| Pingda Ren | SVP-Chemistry&Pharma Sciences | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jan 2016 | 50,000 | 50,000 | - | - | Option to purchase common stock | |
| Thomas R. Malley | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 10 Nov 2015 | 50,000 | 89,557 | - | - | Common stock |