151.6K XNAS Volume
XNAS 20 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 176.80 per share. | 13 Mar 2025 | 4,944 | 1,552,012 (8%) | 0% | 176.8 | 874,123 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 179.57 per share. | 13 Mar 2025 | 1,256 | 1,533,056 (8%) | 0% | 179.6 | 225,544 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 178.77 per share. | 13 Mar 2025 | 6,769 | 1,534,312 (8%) | 0% | 178.8 | 1,210,077 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 177.62 per share. | 13 Mar 2025 | 10,931 | 1,541,081 (8%) | 0% | 177.6 | 1,941,611 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 176.80 per share. | 13 Mar 2025 | 4,944 | 1,552,012 (8%) | 0% | 176.8 | 874,123 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 175.83 per share. | 13 Mar 2025 | 1,100 | 1,556,956 (8%) | 0% | 175.8 | 193,408 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 179.55 per share. | 13 Mar 2025 | 1,331 | 1,463,711 (8%) | 0% | 179.5 | 238,977 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 178.76 per share. | 13 Mar 2025 | 6,514 | 1,465,042 (8%) | 0% | 178.8 | 1,164,415 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 177.66 per share. | 13 Mar 2025 | 10,937 | 1,471,556 (8%) | 0% | 177.7 | 1,943,027 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 176.88 per share. | 13 Mar 2025 | 4,579 | 1,482,493 (8%) | 0% | 176.9 | 809,924 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 175.97 per share. | 13 Mar 2025 | 1,639 | 1,487,072 (8%) | 0% | 176.0 | 288,419 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 179.55 per share. | 13 Mar 2025 | 1,331 | 1,463,711 (8%) | 0% | 179.5 | 238,977 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 178.76 per share. | 13 Mar 2025 | 6,514 | 1,465,042 (8%) | 0% | 178.8 | 1,164,415 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 177.66 per share. | 13 Mar 2025 | 10,937 | 1,471,556 (8%) | 0% | 177.7 | 1,943,027 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 176.88 per share. | 13 Mar 2025 | 4,579 | 1,482,493 (8%) | 0% | 176.9 | 809,924 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 175.97 per share. | 13 Mar 2025 | 1,639 | 1,487,072 (8%) | 0% | 176.0 | 288,419 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 179.57 per share. | 13 Mar 2025 | 1,256 | 1,533,056 (8%) | 0% | 179.6 | 225,544 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 178.77 per share. | 13 Mar 2025 | 6,769 | 1,534,312 (8%) | 0% | 178.8 | 1,210,077 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 177.62 per share. | 13 Mar 2025 | 10,931 | 1,541,081 (8%) | 0% | 177.6 | 1,941,611 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 175.83 per share. | 13 Mar 2025 | 1,100 | 1,556,956 (8%) | 0% | 175.8 | 193,408 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 176.39 per share. | 26 Feb 2025 | 4,721 | 1,558,056 (9%) | 0% | 176.4 | 832,737 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 12,149 | 1,562,777 (9%) | 0% | 179.2 | 2,177,708 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 26,250 | 1,574,926 (9%) | 0% | 0 | Common Stock | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 4,050 | 1,548,676 (8%) | 0% | 179.3 | 725,963 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 8,750 | 1,552,726 (8%) | 0% | 0 | Common Stock | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 5,786 | 1,543,976 (8%) | 0% | 179.3 | 1,037,141 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 12,500 | 1,549,762 (8%) | 0% | 0 | Common Stock | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 10,414 | 1,488,711 (8%) | 0% | 179.3 | 1,866,710 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 22,500 | 1,499,125 (8%) | 0% | 0 | Common Stock | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 3,471 | 1,476,625 (8%) | 0% | 179.3 | 622,177 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 7,500 | 1,480,096 (8%) | 0% | 0 | Common Stock | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 176.39 per share. | 26 Feb 2025 | 3,286 | 1,472,596 (8%) | 0% | 176.4 | 579,618 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 22,900 | 22,900 | - | - | Restricted Stock Units | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 26,250 | 26,250 | - | - | Performance Stock Units | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 39,300 | 39,300 | - | - | Stock Option (Right to Buy) | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 7,500 | 0 | - | - | Performance Stock Units | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 22,500 | 22,500 | - | - | Performance Stock Units | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 16,000 | 16,000 | - | - | Restricted Stock Units | |
| Kathryn A. Romano | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 176.39 per share. | 26 Feb 2025 | 2,268 | 13,354 (0%) | 0% | 176.4 | 400,053 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 175.22 per share. | 26 Feb 2025 | 750 | 12,604 (0%) | 0% | 175.2 | 131,415 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 5,000 | 17,604 (0%) | 0% | 0 | Common Stock | |
| Kathryn A. Romano | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 2,315 | 15,289 (0%) | 0% | 179.3 | 414,964 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 7,500 | 22,789 (0%) | 0% | 0 | Common Stock | |
| Kathryn A. Romano | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 3,471 | 19,318 (0%) | 0% | 179.3 | 622,177 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 5,000 | 0 | - | - | Performance Stock Units | |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 7,500 | 7,500 | - | - | Performance Stock Units | |
| Kathryn A. Romano | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Kathryn A. Romano | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 2,200 | 2,200 | - | - | Restricted Stock Units | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 8,750 | 26,250 | - | - | Restricted Stock Units | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 176.39 per share. | 26 Feb 2025 | 4,721 | 1,532,541 (8%) | 0% | 176.4 | 832,737 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 12,500 | 1,545,041 (8%) | 0% | 0 | Common Stock | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 5,786 | 1,539,255 (8%) | 0% | 179.3 | 1,037,141 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 8,750 | 1,548,005 (8%) | 0% | 0 | Common Stock | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 4,050 | 1,543,955 (8%) | 0% | 179.3 | 725,963 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 26,250 | 1,570,205 (9%) | 0% | 0 | Common Stock | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 12,149 | 1,558,056 (9%) | 0% | 179.2 | 2,177,708 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 7,500 | 1,483,382 (8%) | 0% | 0 | Common Stock | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 3,471 | 1,479,911 (8%) | 0% | 179.3 | 622,177 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 22,500 | 1,502,411 (8%) | 0% | 0 | Common Stock | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 179.25 per share. | 26 Feb 2025 | 10,414 | 1,491,997 (8%) | 0% | 179.3 | 1,866,710 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 176.39 per share. | 26 Feb 2025 | 3,286 | 1,488,711 (8%) | 0% | 176.4 | 579,618 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2025 | 12,500 | 0 | - | - | Performance Stock Units | |
| Krishnan M. Suma | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 163.04 per share. | 13 Dec 2024 | 5,942 | 1,494,940 (8%) | 0% | 163.0 | 968,804 | Common Stock |
| M. Krishnan Suma | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 163.92 per share. | 13 Dec 2024 | 8,923 | 1,486,017 (8%) | 0% | 163.9 | 1,462,617 | Common Stock |
| S. Krish Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 169.48 per share. | 13 Dec 2024 | 953 | 1,477,229 (8%) | 0% | 169.5 | 161,515 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 163.07 per share. | 13 Dec 2024 | 6,302 | 1,555,960 (8%) | 0% | 163.1 | 1,027,661 | Common Stock |
| Krishnan M. Suma | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 166.96 per share. | 13 Dec 2024 | 798 | 1,478,382 (8%) | 0% | 167.0 | 133,233 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 165.79 per share. | 13 Dec 2024 | 2,114 | 1,479,180 (8%) | 0% | 165.8 | 350,490 | Common Stock |
| M. Krishnan Suma | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 165.79 per share. | 13 Dec 2024 | 2,114 | 1,479,180 (8%) | 0% | 165.8 | 350,490 | Common Stock |
| Krishnan Suma M. | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 164.92 per share. | 13 Dec 2024 | 4,723 | 1,481,294 (8%) | 0% | 164.9 | 778,894 | Common Stock |
| M. Krishnan Suma | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 166.93 per share. | 13 Dec 2024 | 923 | 1,539,770 (8%) | 0% | 166.9 | 154,074 | Common Stock |
| Suma Krishnan M. | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 170.43 per share. | 13 Dec 2024 | 727 | 1,476,502 (8%) | 0% | 170.4 | 123,903 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 171.62 per share. | 13 Dec 2024 | 620 | 1,475,882 (8%) | 0% | 171.6 | 106,407 | Common Stock |
| S. Krishnan Krish | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 168.31 per share. | 13 Dec 2024 | 200 | 1,478,182 (8%) | 0% | 168.3 | 33,662 | Common Stock |
| S. Krish Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 170.43 per share. | 13 Dec 2024 | 727 | 1,476,502 (8%) | 0% | 170.4 | 123,903 | Common Stock |
| S. Krish Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 164.92 per share. | 13 Dec 2024 | 4,723 | 1,481,294 (8%) | 0% | 164.9 | 778,894 | Common Stock |
| Suma Krishnan M. | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 169.48 per share. | 13 Dec 2024 | 953 | 1,477,229 (8%) | 0% | 169.5 | 161,515 | Common Stock |
| Suma Krishnan M. | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 171.63 per share. | 13 Dec 2024 | 640 | 1,537,262 (8%) | 0% | 171.6 | 109,842 | Common Stock |
| M. Suma Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 163.91 per share. | 13 Dec 2024 | 8,381 | 1,547,579 (8%) | 0% | 163.9 | 1,373,756 | Common Stock |
| M. Krishnan Suma | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 169.65 per share. | 13 Dec 2024 | 911 | 1,538,859 (8%) | 0% | 169.6 | 154,550 | Common Stock |
| S. Krish Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 163.91 per share. | 13 Dec 2024 | 8,381 | 1,547,579 (8%) | 0% | 163.9 | 1,373,756 | Common Stock |
| S. Krish Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 163.07 per share. | 13 Dec 2024 | 6,302 | 1,555,960 (8%) | 0% | 163.1 | 1,027,661 | Common Stock |
| S. Krish Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 165.82 per share. | 13 Dec 2024 | 1,977 | 1,540,693 (8%) | 0% | 165.8 | 327,833 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 166.96 per share. | 13 Dec 2024 | 798 | 1,478,382 (8%) | 0% | 167.0 | 133,233 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 170.47 per share. | 13 Dec 2024 | 957 | 1,537,902 (8%) | 0% | 170.5 | 163,139 | Common Stock |
| Krishnan Krish S. | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 169.65 per share. | 13 Dec 2024 | 911 | 1,538,859 (8%) | 0% | 169.6 | 154,550 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 170.47 per share. | 13 Dec 2024 | 957 | 1,537,902 (8%) | 0% | 170.5 | 163,139 | Common Stock |
| Krishnan Krish S. | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 163.92 per share. | 13 Dec 2024 | 8,923 | 1,486,017 (8%) | 0% | 163.9 | 1,462,617 | Common Stock |
| S. Krishnan Krish | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 163.04 per share. | 13 Dec 2024 | 5,942 | 1,494,940 (8%) | 0% | 163.0 | 968,804 | Common Stock |
| Krishnan S. Krish | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 171.62 per share. | 13 Dec 2024 | 620 | 1,475,882 (8%) | 0% | 171.6 | 106,407 | Common Stock |
| Krishnan Krish S. | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 164.93 per share. | 13 Dec 2024 | 4,909 | 1,542,670 (8%) | 0% | 164.9 | 809,644 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 164.93 per share. | 13 Dec 2024 | 4,909 | 1,542,670 (8%) | 0% | 164.9 | 809,644 | Common Stock |
| M. Suma Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 168.31 per share. | 13 Dec 2024 | 200 | 1,478,182 (8%) | 0% | 168.3 | 33,662 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 171.63 per share. | 13 Dec 2024 | 640 | 1,537,262 (8%) | 0% | 171.6 | 109,842 | Common Stock |
| Krishnan Suma M. | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 165.82 per share. | 13 Dec 2024 | 1,977 | 1,540,693 (8%) | 0% | 165.8 | 327,833 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 166.93 per share. | 13 Dec 2024 | 923 | 1,539,770 (8%) | 0% | 166.9 | 154,074 | Common Stock |
| Dino A. Rossi | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 13 Sep 2024 | 5,000 | 78,691 (0%) | 0% | 0 | Common Stock | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 201.52 per share. | 12 Sep 2024 | 1,895 | 1,500,882 (8%) | 0% | 201.5 | 381,876 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 200.42 per share. | 12 Sep 2024 | 4,159 | 1,502,777 (8%) | 0% | 200.4 | 833,526 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 199.22 per share. | 12 Sep 2024 | 2,945 | 1,506,936 (8%) | 0% | 199.2 | 586,712 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 198.43 per share. | 12 Sep 2024 | 3,392 | 1,509,881 (8%) | 0% | 198.4 | 673,085 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 197.55 per share. | 12 Sep 2024 | 1,385 | 1,513,273 (8%) | 0% | 197.5 | 273,600 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 196.07 per share. | 12 Sep 2024 | 2,727 | 1,514,658 (8%) | 0% | 196.1 | 534,674 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 195.43 per share. | 12 Sep 2024 | 8,497 | 1,517,385 (8%) | 0% | 195.4 | 1,660,566 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 201.81 per share. | 12 Sep 2024 | 800 | 1,562,262 (9%) | 0% | 201.8 | 161,447 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 200.98 per share. | 12 Sep 2024 | 2,395 | 1,563,062 (9%) | 0% | 201.0 | 481,337 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 200.15 per share. | 12 Sep 2024 | 3,600 | 1,565,457 (9%) | 0% | 200.2 | 720,548 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 198.93 per share. | 12 Sep 2024 | 4,008 | 1,569,057 (9%) | 0% | 198.9 | 797,297 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 198.08 per share. | 12 Sep 2024 | 2,086 | 1,573,065 (9%) | 0% | 198.1 | 413,196 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 197.04 per share. | 12 Sep 2024 | 1,696 | 1,575,151 (9%) | 0% | 197.0 | 334,178 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 195.72 per share. | 12 Sep 2024 | 6,458 | 1,576,847 (9%) | 0% | 195.7 | 1,263,977 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 195.16 per share. | 12 Sep 2024 | 3,957 | 1,583,305 (9%) | 0% | 195.2 | 772,259 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 195.43 per share. | 12 Sep 2024 | 8,497 | 1,517,385 (8%) | 0% | 195.4 | 1,660,566 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 201.81 per share. | 12 Sep 2024 | 800 | 1,562,262 (9%) | 0% | 201.8 | 161,447 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 200.98 per share. | 12 Sep 2024 | 2,395 | 1,563,062 (9%) | 0% | 201.0 | 481,337 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 200.15 per share. | 12 Sep 2024 | 3,600 | 1,565,457 (9%) | 0% | 200.2 | 720,548 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 198.93 per share. | 12 Sep 2024 | 4,008 | 1,569,057 (9%) | 0% | 198.9 | 797,297 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 198.08 per share. | 12 Sep 2024 | 2,086 | 1,573,065 (9%) | 0% | 198.1 | 413,196 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 197.04 per share. | 12 Sep 2024 | 1,696 | 1,575,151 (9%) | 0% | 197.0 | 334,178 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 195.72 per share. | 12 Sep 2024 | 6,458 | 1,576,847 (9%) | 0% | 195.7 | 1,263,977 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 195.16 per share. | 12 Sep 2024 | 3,957 | 1,583,305 (9%) | 0% | 195.2 | 772,259 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 201.52 per share. | 12 Sep 2024 | 1,895 | 1,500,882 (8%) | 0% | 201.5 | 381,876 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 200.42 per share. | 12 Sep 2024 | 4,159 | 1,502,777 (8%) | 0% | 200.4 | 833,526 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 199.22 per share. | 12 Sep 2024 | 2,945 | 1,506,936 (8%) | 0% | 199.2 | 586,712 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 198.43 per share. | 12 Sep 2024 | 3,392 | 1,509,881 (8%) | 0% | 198.4 | 673,085 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 197.55 per share. | 12 Sep 2024 | 1,385 | 1,513,273 (8%) | 0% | 197.5 | 273,600 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 196.07 per share. | 12 Sep 2024 | 2,727 | 1,514,658 (8%) | 0% | 196.1 | 534,674 | Common Stock |
| Daniel S. Janney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Dino A. Rossi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Julian S. Gangolli | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Christopher Mason | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Everett Rand Sutherland | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Catherine Mazzacco | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2024 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 176.68 per share. | 11 Jun 2024 | 5,705 | 1,593,707 (9%) | 0% | 176.7 | 1,007,951 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 177.68 per share. | 11 Jun 2024 | 5,447 | 1,588,260 (9%) | 0% | 177.7 | 967,814 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 178.36 per share. | 11 Jun 2024 | 998 | 1,587,262 (9%) | 0% | 178.4 | 178,000 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 171.40 per share. | 11 Jun 2024 | 900 | 1,549,982 (8%) | 0% | 171.4 | 154,257 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 172.24 per share. | 11 Jun 2024 | 2,099 | 1,547,883 (8%) | 0% | 172.2 | 361,529 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 173.41 per share. | 11 Jun 2024 | 1,206 | 1,546,677 (8%) | 0% | 173.4 | 209,137 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 174.50 per share. | 11 Jun 2024 | 1,724 | 1,544,953 (8%) | 0% | 174.5 | 300,831 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 175.33 per share. | 11 Jun 2024 | 4,975 | 1,539,978 (8%) | 0% | 175.3 | 872,273 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 176.37 per share. | 11 Jun 2024 | 5,867 | 1,534,111 (8%) | 0% | 176.4 | 1,034,792 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 177.38 per share. | 11 Jun 2024 | 6,358 | 1,527,753 (8%) | 0% | 177.4 | 1,127,773 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 178.14 per share. | 11 Jun 2024 | 1,871 | 1,525,882 (8%) | 0% | 178.1 | 333,309 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 171.49 per share. | 11 Jun 2024 | 1,100 | 1,611,162 (9%) | 0% | 171.5 | 188,637 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 172.21 per share. | 11 Jun 2024 | 1,882 | 1,609,280 (9%) | 0% | 172.2 | 324,104 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 173.49 per share. | 11 Jun 2024 | 1,318 | 1,607,962 (9%) | 0% | 173.5 | 228,657 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 174.83 per share. | 11 Jun 2024 | 4,000 | 1,603,962 (9%) | 0% | 174.8 | 699,304 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 175.76 per share. | 11 Jun 2024 | 4,550 | 1,599,412 (9%) | 0% | 175.8 | 799,693 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 171.40 per share. | 11 Jun 2024 | 900 | 1,549,982 (8%) | 0% | 171.4 | 154,257 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 172.24 per share. | 11 Jun 2024 | 2,099 | 1,547,883 (8%) | 0% | 172.2 | 361,529 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 173.41 per share. | 11 Jun 2024 | 1,206 | 1,546,677 (8%) | 0% | 173.4 | 209,137 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 174.50 per share. | 11 Jun 2024 | 1,724 | 1,544,953 (8%) | 0% | 174.5 | 300,831 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 176.37 per share. | 11 Jun 2024 | 5,867 | 1,534,111 (8%) | 0% | 176.4 | 1,034,792 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 175.33 per share. | 11 Jun 2024 | 4,975 | 1,539,978 (8%) | 0% | 175.3 | 872,273 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 178.36 per share. | 11 Jun 2024 | 998 | 1,587,262 (9%) | 0% | 178.4 | 178,000 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 177.68 per share. | 11 Jun 2024 | 5,447 | 1,588,260 (9%) | 0% | 177.7 | 967,814 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 176.68 per share. | 11 Jun 2024 | 5,705 | 1,593,707 (9%) | 0% | 176.7 | 1,007,951 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 175.76 per share. | 11 Jun 2024 | 4,550 | 1,599,412 (9%) | 0% | 175.8 | 799,693 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 174.83 per share. | 11 Jun 2024 | 4,000 | 1,603,962 (9%) | 0% | 174.8 | 699,304 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 173.49 per share. | 11 Jun 2024 | 1,318 | 1,607,962 (9%) | 0% | 173.5 | 228,657 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 172.21 per share. | 11 Jun 2024 | 1,882 | 1,609,280 (9%) | 0% | 172.2 | 324,104 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 171.49 per share. | 11 Jun 2024 | 1,100 | 1,611,162 (9%) | 0% | 171.5 | 188,637 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 178.14 per share. | 11 Jun 2024 | 1,871 | 1,525,882 (8%) | 0% | 178.1 | 333,309 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 177.38 per share. | 11 Jun 2024 | 6,358 | 1,527,753 (8%) | 0% | 177.4 | 1,127,773 | Common Stock |
| Julian S. Gangolli | Director | Sale of securities on an exchange or to another person at price $ 164.34 per share. | 20 May 2024 | 7,090 | 1,980 (0%) | 0% | 164.3 | 1,165,180 | Common Stock |
| Julian S. Gangolli | Director | Sale of securities on an exchange or to another person at price $ 163.71 per share. | 20 May 2024 | 10,930 | 9,070 (0%) | 0% | 163.7 | 1,789,310 | Common Stock |
| Julian S. Gangolli | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.75 per share. | 20 May 2024 | 20,000 | 20,000 (0%) | 0% | 22.8 | 455,000 | Common Stock |
| Julian S. Gangolli | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 May 2024 | 20,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Julian S. Gangolli | Director | Sale of securities on an exchange or to another person at price $ 165.76 per share. | 20 May 2024 | 1,980 | 0 (0%) | 0% | 165.8 | 328,200 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 173.30 per share. | 11 Mar 2024 | 3,587 | 1,551,682 (8%) | 0% | 173.3 | 621,624 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 174.13 per share. | 11 Mar 2024 | 800 | 1,550,882 (8%) | 0% | 174.1 | 139,305 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 172.21 per share. | 11 Mar 2024 | 2,800 | 1,555,269 (8%) | 0% | 172.2 | 482,176 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 171.09 per share. | 11 Mar 2024 | 5,469 | 1,558,069 (9%) | 0% | 171.1 | 935,713 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 170.42 per share. | 11 Mar 2024 | 8,040 | 1,563,538 (9%) | 0% | 170.4 | 1,370,174 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 168.96 per share. | 11 Mar 2024 | 1,646 | 1,571,578 (9%) | 0% | 169.0 | 278,104 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 168.15 per share. | 11 Mar 2024 | 2,658 | 1,573,224 (9%) | 0% | 168.2 | 446,945 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 174.00 per share. | 11 Mar 2024 | 1,314 | 1,612,262 (9%) | 0% | 174.0 | 228,631 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 173.09 per share. | 11 Mar 2024 | 3,359 | 1,613,576 (9%) | 0% | 173.1 | 581,402 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 172.06 per share. | 11 Mar 2024 | 2,816 | 1,616,935 (9%) | 0% | 172.1 | 484,519 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 170.93 per share. | 11 Mar 2024 | 8,002 | 1,619,751 (9%) | 0% | 170.9 | 1,367,770 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 170.32 per share. | 11 Mar 2024 | 5,109 | 1,627,753 (9%) | 0% | 170.3 | 870,186 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 168.88 per share. | 11 Mar 2024 | 2,254 | 1,632,862 (9%) | 0% | 168.9 | 380,660 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 167.99 per share. | 11 Mar 2024 | 2,146 | 1,635,116 (9%) | 0% | 168.0 | 360,511 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 174.13 per share. | 11 Mar 2024 | 800 | 1,550,882 (8%) | 0% | 174.1 | 139,305 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 174.00 per share. | 11 Mar 2024 | 1,314 | 1,612,262 (9%) | 0% | 174.0 | 228,631 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 173.09 per share. | 11 Mar 2024 | 3,359 | 1,613,576 (9%) | 0% | 173.1 | 581,402 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 172.06 per share. | 11 Mar 2024 | 2,816 | 1,616,935 (9%) | 0% | 172.1 | 484,519 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 170.93 per share. | 11 Mar 2024 | 8,002 | 1,619,751 (9%) | 0% | 170.9 | 1,367,770 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 170.32 per share. | 11 Mar 2024 | 5,109 | 1,627,753 (9%) | 0% | 170.3 | 870,186 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 168.88 per share. | 11 Mar 2024 | 2,254 | 1,632,862 (9%) | 0% | 168.9 | 380,660 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 167.99 per share. | 11 Mar 2024 | 2,146 | 1,635,116 (9%) | 0% | 168.0 | 360,511 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 173.30 per share. | 11 Mar 2024 | 3,587 | 1,551,682 (8%) | 0% | 173.3 | 621,624 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 172.21 per share. | 11 Mar 2024 | 2,800 | 1,555,269 (8%) | 0% | 172.2 | 482,176 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 171.09 per share. | 11 Mar 2024 | 5,469 | 1,558,069 (9%) | 0% | 171.1 | 935,713 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 170.42 per share. | 11 Mar 2024 | 8,040 | 1,563,538 (9%) | 0% | 170.4 | 1,370,174 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 168.96 per share. | 11 Mar 2024 | 1,646 | 1,571,578 (9%) | 0% | 169.0 | 278,104 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 168.15 per share. | 11 Mar 2024 | 2,658 | 1,573,224 (9%) | 0% | 168.2 | 446,945 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 12,500 | 1,643,047 (9%) | 0% | 0 | Common Stock | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2024 | 52,500 | 52,500 | - | - | Performance Stock Units | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2024 | 35,000 | 35,000 | - | - | Restricted Stock Units | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 12,500 | 12,500 | - | - | Performance Stock Units | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.08 per share. | 28 Feb 2024 | 3,471 | 1,575,882 (9%) | 0% | 163.1 | 566,051 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 7,500 | 1,579,353 (9%) | 0% | 0 | Common Stock | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.08 per share. | 28 Feb 2024 | 5,785 | 1,637,262 (9%) | 0% | 163.1 | 943,418 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2024 | 45,000 | 45,000 | - | - | Performance Stock Units | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 7,500 | 7,500 | - | - | Performance Stock Units | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.08 per share. | 28 Feb 2024 | 5,785 | 1,637,262 (9%) | 0% | 163.1 | 943,418 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 12,500 | 1,643,047 (9%) | 0% | 0 | Common Stock | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.08 per share. | 28 Feb 2024 | 3,471 | 1,575,882 (9%) | 0% | 163.1 | 566,051 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 7,500 | 1,579,353 (9%) | 0% | 0 | Common Stock | |
| Kathryn A. Romano | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2024 | 15,000 | 15,000 | - | - | Performance Stock Units | |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 648 | 13,584 (0%) | 0% | 63.5 | 41,180 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 162.71 per share. | 28 Feb 2024 | 648 | 12,936 (0%) | 0% | 162.7 | 105,436 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 900 | 13,836 (0%) | 0% | 63.6 | 57,195 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 163.68 per share. | 28 Feb 2024 | 900 | 12,936 (0%) | 0% | 163.7 | 147,308 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 1,429 | 14,365 (0%) | 0% | 63.6 | 90,813 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 164.81 per share. | 28 Feb 2024 | 1,429 | 12,936 (0%) | 0% | 164.8 | 235,510 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 300 | 13,236 (0%) | 0% | 63.6 | 19,065 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 166.06 per share. | 28 Feb 2024 | 300 | 12,936 (0%) | 0% | 166.1 | 49,819 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 300 | 13,236 (0%) | 0% | 63.6 | 19,065 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 167.85 per share. | 28 Feb 2024 | 300 | 12,936 (0%) | 0% | 167.9 | 50,355 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 1,216 | 14,152 (0%) | 0% | 63.6 | 77,277 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 169.09 per share. | 28 Feb 2024 | 1,216 | 12,936 (0%) | 0% | 169.1 | 205,619 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 117 | 13,053 (0%) | 0% | 63.5 | 7,435 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 169.82 per share. | 28 Feb 2024 | 117 | 12,936 (0%) | 0% | 169.8 | 19,869 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.56 per share. | 28 Feb 2024 | 90 | 13,026 (0%) | 0% | 63.6 | 5,720 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 172.23 per share. | 28 Feb 2024 | 90 | 12,936 (0%) | 0% | 172.2 | 15,501 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 5,000 | 17,936 (0%) | 0% | 0 | Common Stock | |
| Kathryn A. Romano | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 163.08 per share. | 28 Feb 2024 | 2,314 | 15,622 (0%) | 0% | 163.1 | 377,367 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 5,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 5,000 | 5,000 | - | - | Performance Stock Units | |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 523 | 13,459 (0%) | 0% | 63.6 | 33,237 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 163.13 per share. | 28 Feb 2024 | 523 | 12,936 (0%) | 0% | 163.1 | 85,319 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 744 | 13,680 (0%) | 0% | 63.5 | 47,281 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 164.60 per share. | 28 Feb 2024 | 744 | 12,936 (0%) | 0% | 164.6 | 122,465 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 130 | 13,066 (0%) | 0% | 63.6 | 8,262 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 165.22 per share. | 28 Feb 2024 | 130 | 12,936 (0%) | 0% | 165.2 | 21,479 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 100 | 13,036 (0%) | 0% | 63.6 | 6,355 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 166.22 per share. | 28 Feb 2024 | 100 | 12,936 (0%) | 0% | 166.2 | 16,622 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 700 | 13,636 (0%) | 0% | 63.6 | 44,485 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 168.91 per share. | 28 Feb 2024 | 700 | 12,936 (0%) | 0% | 168.9 | 118,240 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 203 | 13,139 (0%) | 0% | 63.6 | 12,901 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 169.47 per share. | 28 Feb 2024 | 203 | 12,936 (0%) | 0% | 169.5 | 34,402 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 100 | 13,036 (0%) | 0% | 63.6 | 6,355 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 171.45 per share. | 28 Feb 2024 | 100 | 12,936 (0%) | 0% | 171.5 | 17,145 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 637 | 13,573 (0%) | 0% | 63.5 | 40,481 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 162.73 per share. | 28 Feb 2024 | 637 | 12,936 (0%) | 0% | 162.7 | 103,656 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 786 | 13,722 (0%) | 0% | 63.5 | 49,950 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 163.49 per share. | 28 Feb 2024 | 786 | 12,936 (0%) | 0% | 163.5 | 128,506 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 1,600 | 14,536 (0%) | 0% | 63.6 | 101,680 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 164.84 per share. | 28 Feb 2024 | 1,600 | 12,936 (0%) | 0% | 164.8 | 263,751 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 200 | 13,136 (0%) | 0% | 63.6 | 12,710 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 166.04 per share. | 28 Feb 2024 | 200 | 12,936 (0%) | 0% | 166.0 | 33,208 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 300 | 13,236 (0%) | 0% | 63.6 | 19,065 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 167.85 per share. | 28 Feb 2024 | 300 | 12,936 (0%) | 0% | 167.9 | 50,355 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 1,133 | 14,069 (0%) | 0% | 63.5 | 72,002 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 169.10 per share. | 28 Feb 2024 | 1,133 | 12,936 (0%) | 0% | 169.1 | 191,585 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 210 | 13,146 (0%) | 0% | 63.6 | 13,346 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 169.75 per share. | 28 Feb 2024 | 210 | 12,936 (0%) | 0% | 169.8 | 35,648 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 28 Feb 2024 | 134 | 13,070 (0%) | 0% | 63.6 | 8,516 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 171.66 per share. | 28 Feb 2024 | 134 | 12,936 (0%) | 0% | 171.7 | 23,002 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 2,500 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 5,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Kathryn Romano A. | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 157.00 per share. | 26 Feb 2024 | 1,533 | 11,023 (0%) | 0% | 157 | 240,681 | Common Stock |
| Krishnan M. Suma | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 157.00 per share. | 26 Feb 2024 | 2,353 | 1,571,853 (9%) | 0% | 157 | 369,421 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.26 per share. | 26 Feb 2024 | 3,087 | 15,643 (0%) | 0% | 52.3 | 161,327 | Common Stock |
| Romano Kathryn A. | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 135.00 per share. | 26 Feb 2024 | 5,000 | 12,556 (0%) | 0% | 135 | 675,000 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.26 per share. | 26 Feb 2024 | 5,000 | 17,556 (0%) | 0% | 52.3 | 261,300 | Common Stock |
| A. Kathryn Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2024 | 1,913 | 0 | - | - | Stock Option (Right to Buy) | |
| A. Romano Kathryn | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2024 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Romano Kathryn A. | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2024 | 3,087 | 1,913 | - | - | Stock Option (Right to Buy) | |
| Krish Krishnan S. | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 157.00 per share. | 26 Feb 2024 | 3,791 | 1,630,547 (9%) | 0% | 157 | 595,187 | Common Stock |
| Romano A. Kathryn | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 140.00 per share. | 26 Feb 2024 | 3,087 | 12,556 (0%) | 0% | 140 | 432,180 | Common Stock |
| A. Romano Kathryn | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.26 per share. | 26 Feb 2024 | 1,913 | 12,936 (0%) | 0% | 52.3 | 99,973 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.26 per share. | 22 Jan 2024 | 2,500 | 15,056 (0%) | 0% | 52.3 | 130,650 | Common Stock |
| Romano Kathryn A. | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jan 2024 | 2,500 | 10,000 | - | - | Stock Option (Right to Buy) | |
| A. Kathryn Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 130.00 per share. | 22 Jan 2024 | 2,500 | 12,556 (0%) | 0% | 130 | 325,000 | Common Stock |
| Krishnan M. Suma | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 107.66 per share. | 11 Dec 2023 | 100 | 1,574,206 (9%) | 0% | 107.7 | 10,766 | Common Stock |
| M. Suma Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 107.66 per share. | 11 Dec 2023 | 100 | 1,634,338 (9%) | 0% | 107.7 | 10,766 | Common Stock |
| Krishnan Krish S. | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 106.11 per share. | 11 Dec 2023 | 14,237 | 1,634,438 (9%) | 0% | 106.1 | 1,510,667 | Common Stock |
| Suma Krishnan M. | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 105.06 per share. | 11 Dec 2023 | 4,541 | 1,591,811 (9%) | 0% | 105.1 | 477,087 | Common Stock |
| S. Krish Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 106.04 per share. | 11 Dec 2023 | 17,505 | 1,574,306 (9%) | 0% | 106.0 | 1,856,241 | Common Stock |
| Krish Krishnan S. | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 104.41 per share. | 11 Dec 2023 | 4,400 | 1,654,938 (9%) | 0% | 104.4 | 459,424 | Common Stock |
| Krishnan M. Suma | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 104.26 per share. | 11 Dec 2023 | 2,854 | 1,596,352 (9%) | 0% | 104.3 | 297,569 | Common Stock |
| Krishnan M. Suma | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 105.50 per share. | 11 Dec 2023 | 6,263 | 1,648,675 (9%) | 0% | 105.5 | 660,771 | Common Stock |
| Krishnan M. Suma | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 104.41 per share. | 11 Dec 2023 | 4,400 | 1,654,938 (9%) | 0% | 104.4 | 459,424 | Common Stock |
| S. Krishnan Krish | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 105.06 per share. | 11 Dec 2023 | 4,541 | 1,591,811 (9%) | 0% | 105.1 | 477,087 | Common Stock |
| Krishnan Krish S. | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 104.26 per share. | 11 Dec 2023 | 2,854 | 1,596,352 (9%) | 0% | 104.3 | 297,569 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 106.11 per share. | 11 Dec 2023 | 14,237 | 1,634,438 (9%) | 0% | 106.1 | 1,510,667 | Common Stock |
| S. Krish Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 105.50 per share. | 11 Dec 2023 | 6,263 | 1,648,675 (9%) | 0% | 105.5 | 660,771 | Common Stock |
| Krishnan M. Suma | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 106.04 per share. | 11 Dec 2023 | 17,505 | 1,574,306 (9%) | 0% | 106.0 | 1,856,241 | Common Stock |
| S. Krish Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 107.66 per share. | 11 Dec 2023 | 100 | 1,634,338 (9%) | 0% | 107.7 | 10,766 | Common Stock |
| Krish Krishnan S. | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 107.66 per share. | 11 Dec 2023 | 100 | 1,574,206 (9%) | 0% | 107.7 | 10,766 | Common Stock |
| Daniel S. Janney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Dino A. Rossi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Julian S. Gangolli | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Christopher Mason | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Everett Rand Sutherland | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Catherine Mazzacco | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2023 | 2,180 | 2,180 | - | - | Stock Option (Right to Buy) | |
| Andrew C. Orth | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 129.70 per share. | 09 Jun 2023 | 333 | 100 (0%) | 0% | 129.7 | 43,189 | Common Stock |
| Andrew C. Orth | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 09 Jun 2023 | 12,500 | 12,600 (0%) | 0% | 63.6 | 794,375 | Common Stock |
| Andrew C. Orth | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 128.10 per share. | 09 Jun 2023 | 5,261 | 7,339 (0%) | 0% | 128.1 | 673,958 | Common Stock |
| Andrew C. Orth | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 128.94 per share. | 09 Jun 2023 | 6,906 | 433 (0%) | 0% | 128.9 | 890,488 | Common Stock |
| Andrew C. Orth | Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jun 2023 | 12,500 | 37,500 | - | - | Stock Option (Right to Buy) | |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 129.02 per share. | 08 Jun 2023 | 1,073 | 151,685 (0%) | 0% | 129.0 | 138,440 | Common Stock |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 128.84 per share. | 08 Jun 2023 | 5,000 | 117,362 (0%) | 0% | 128.8 | 644,188 | Common Stock |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 129.29 per share. | 08 Jun 2023 | 3,935 | 122,362 (0%) | 0% | 129.3 | 508,773 | Common Stock |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 127.86 per share. | 08 Jun 2023 | 5,000 | 126,297 (0%) | 0% | 127.9 | 639,306 | Common Stock |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 127.96 per share. | 08 Jun 2023 | 10,000 | 131,297 (0%) | 0% | 128.0 | 1,279,584 | Common Stock |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 127.96 per share. | 08 Jun 2023 | 5,000 | 141,297 (0%) | 0% | 128.0 | 639,790 | Common Stock |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 128.73 per share. | 08 Jun 2023 | 5,388 | 146,297 (0%) | 0% | 128.7 | 693,616 | Common Stock |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 128.53 per share. | 08 Jun 2023 | 10,000 | 107,362 (0%) | 0% | 128.5 | 1,285,262 | Common Stock |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 127.96 per share. | 08 Jun 2023 | 4,604 | 152,758 (0%) | 0% | 128.0 | 589,118 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 116.95 per share. | 31 May 2023 | 5,716 | 1,684,738 (9%) | 0% | 116.9 | 668,485 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 117.60 per share. | 31 May 2023 | 400 | 1,684,338 (9%) | 0% | 117.6 | 47,042 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 115.98 per share. | 31 May 2023 | 20,143 | 1,629,063 (9%) | 0% | 116.0 | 2,336,099 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 116.00 per share. | 31 May 2023 | 18,884 | 1,690,454 (9%) | 0% | 116.0 | 2,190,450 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 116.86 per share. | 31 May 2023 | 4,557 | 1,624,506 (9%) | 0% | 116.9 | 532,542 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 117.57 per share. | 31 May 2023 | 300 | 1,624,206 (9%) | 0% | 117.6 | 35,272 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 117.60 per share. | 31 May 2023 | 400 | 1,684,338 (9%) | 0% | 117.6 | 47,042 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 116.95 per share. | 31 May 2023 | 5,716 | 1,684,738 (9%) | 0% | 116.9 | 668,485 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 116.00 per share. | 31 May 2023 | 18,884 | 1,690,454 (9%) | 0% | 116.0 | 2,190,450 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 117.57 per share. | 31 May 2023 | 300 | 1,624,206 (9%) | 0% | 117.6 | 35,272 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 116.86 per share. | 31 May 2023 | 4,557 | 1,624,506 (9%) | 0% | 116.9 | 532,542 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 115.98 per share. | 31 May 2023 | 20,143 | 1,629,063 (9%) | 0% | 116.0 | 2,336,099 | Common Stock |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 95.02 per share. | 19 May 2023 | 50,000 | 157,362 (0%) | 0% | 95.0 | 4,751,185 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2023 | 12,500 | 37,500 | - | - | Stock Option (Right to Buy) | |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2023 | 12,500 | 12,500 | - | - | Stock Option (Right to Buy) | |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2023 | 12,500 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2023 | 12,500 | 37,500 | - | - | Stock Option (Right to Buy) | |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 110.00 per share. | 19 May 2023 | 12,500 | 12,556 (0%) | 0% | 110 | 1,375,000 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 63.55 per share. | 19 May 2023 | 12,500 | 25,056 (0%) | 0% | 63.6 | 794,375 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 109.99 per share. | 19 May 2023 | 3,154 | 12,556 (0%) | 0% | 110.0 | 346,919 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.26 per share. | 19 May 2023 | 3,154 | 15,710 (0%) | 0% | 52.3 | 164,828 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 109.17 per share. | 19 May 2023 | 2,955 | 12,556 (0%) | 0% | 109.2 | 322,603 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.26 per share. | 19 May 2023 | 2,955 | 15,511 (0%) | 0% | 52.3 | 154,428 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 107.88 per share. | 19 May 2023 | 1,300 | 12,556 (0%) | 0% | 107.9 | 140,241 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.26 per share. | 19 May 2023 | 1,300 | 13,856 (0%) | 0% | 52.3 | 67,938 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 106.81 per share. | 19 May 2023 | 2,570 | 12,556 (0%) | 0% | 106.8 | 274,498 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.26 per share. | 19 May 2023 | 2,570 | 15,126 (0%) | 0% | 52.3 | 134,308 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 105.80 per share. | 19 May 2023 | 2,521 | 12,556 (0%) | 0% | 105.8 | 266,731 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.26 per share. | 19 May 2023 | 2,521 | 15,077 (0%) | 0% | 52.3 | 131,747 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 95.08 per share. | 19 May 2023 | 3,428 | 12,556 (0%) | 0% | 95.1 | 325,937 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 95.04 per share. | 19 May 2023 | 12,500 | 15,984 (0%) | 0% | 95.0 | 1,188,061 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.26 per share. | 19 May 2023 | 12,500 | 28,484 (0%) | 0% | 52.3 | 653,250 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 95.05 per share. | 19 May 2023 | 12,500 | 15,984 (0%) | 0% | 95.1 | 1,188,125 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 52.26 per share. | 19 May 2023 | 12,500 | 28,484 (0%) | 0% | 52.3 | 653,250 | Common Stock |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 90.74 per share. | 09 May 2023 | 17,100 | 207,362 (1%) | 0% | 90.7 | 1,551,579 | Common Stock |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 90.32 per share. | 19 Apr 2023 | 7,900 | 224,462 (1%) | 0% | 90.3 | 713,493 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 89.12 per share. | 17 Apr 2023 | 500 | 1,709,338 (9%) | 0% | 89.1 | 44,559 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 85.55 per share. | 17 Apr 2023 | 1,050 | 1,733,288 (10%) | 0% | 85.5 | 89,826 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 86.80 per share. | 17 Apr 2023 | 4,298 | 1,728,990 (9%) | 0% | 86.8 | 373,051 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 87.41 per share. | 17 Apr 2023 | 9,428 | 1,719,562 (9%) | 0% | 87.4 | 824,114 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 88.41 per share. | 17 Apr 2023 | 9,724 | 1,709,838 (9%) | 0% | 88.4 | 859,662 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 85.55 per share. | 17 Apr 2023 | 1,050 | 1,676,213 (9%) | 0% | 85.5 | 89,826 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 86.80 per share. | 17 Apr 2023 | 4,297 | 1,671,916 (9%) | 0% | 86.8 | 372,964 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 87.41 per share. | 17 Apr 2023 | 9,429 | 1,662,487 (9%) | 0% | 87.4 | 824,202 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 88.41 per share. | 17 Apr 2023 | 9,724 | 1,652,763 (9%) | 0% | 88.4 | 859,662 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 89.12 per share. | 17 Apr 2023 | 500 | 1,652,263 (9%) | 0% | 89.1 | 44,559 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 89.12 per share. | 17 Apr 2023 | 500 | 1,713,688 (9%) | 0% | 89.1 | 44,559 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 87.41 per share. | 17 Apr 2023 | 9,429 | 1,659,430 (9%) | 0% | 87.4 | 824,202 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 86.80 per share. | 17 Apr 2023 | 4,297 | 1,668,859 (9%) | 0% | 86.8 | 372,964 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 85.55 per share. | 17 Apr 2023 | 1,050 | 1,673,156 (9%) | 0% | 85.5 | 89,826 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 88.41 per share. | 17 Apr 2023 | 9,724 | 1,714,188 (9%) | 0% | 88.4 | 859,662 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 87.41 per share. | 17 Apr 2023 | 9,428 | 1,723,912 (9%) | 0% | 87.4 | 824,114 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 86.80 per share. | 17 Apr 2023 | 4,298 | 1,733,340 (10%) | 0% | 86.8 | 373,051 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 85.55 per share. | 17 Apr 2023 | 1,050 | 1,737,638 (10%) | 0% | 85.5 | 89,826 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 89.12 per share. | 17 Apr 2023 | 500 | 1,649,206 (9%) | 0% | 89.1 | 44,559 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 88.41 per share. | 17 Apr 2023 | 9,724 | 1,649,706 (9%) | 0% | 88.4 | 859,662 | Common Stock |
| Catherine Mazzacco | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Mar 2023 | 13,600 | 13,600 | - | - | Stock Option (Right to Buy) | |
| Dino A. Rossi | Director | Sale of securities on an exchange or to another person at price $ 83.25 per share. | 01 Mar 2023 | 40,000 | 83,691 (0%) | 0% | 83.2 | 3,329,972 | Common Stock |
| Andrew C. Orth | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 10,000 | 10,000 | - | - | Performance Stock Units | |
| Andrew C. Orth | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2023 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2023 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.46 per share. | 26 Feb 2023 | 4,350 | 1,734,338 (10%) | 0% | 78.5 | 341,301 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2023 | 25,000 | 25,000 | - | - | Performance Stock Units | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.46 per share. | 26 Feb 2023 | 3,057 | 1,674,206 (9%) | 0% | 78.5 | 239,852 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2023 | 15,000 | 15,000 | - | - | Performance Stock Units | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2023 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Kathryn A. Romano | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2023 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Kathryn A. Romano | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2023 | 10,000 | 10,000 | - | - | Performance Stock Units | |
| Kathryn A. Romano | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.46 per share. | 26 Feb 2023 | 2,144 | 15,984 (0%) | 0% | 78.5 | 168,218 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.70 per share. | 17 Jan 2023 | 20,617 | 1,743,071 (10%) | 0% | 80.7 | 1,663,831 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.56 per share. | 17 Jan 2023 | 804 | 1,677,263 (9%) | 0% | 81.6 | 65,574 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.75 per share. | 17 Jan 2023 | 2,048 | 1,678,067 (9%) | 0% | 80.8 | 165,382 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.56 per share. | 17 Jan 2023 | 803 | 1,738,688 (10%) | 0% | 81.6 | 65,492 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.75 per share. | 17 Jan 2023 | 2,048 | 1,739,491 (10%) | 0% | 80.8 | 165,382 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 82.72 per share. | 17 Jan 2023 | 345 | 1,680,115 (9%) | 0% | 82.7 | 28,537 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.41 per share. | 17 Jan 2023 | 1,186 | 1,680,460 (9%) | 0% | 81.4 | 96,548 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.70 per share. | 17 Jan 2023 | 20,617 | 1,681,646 (9%) | 0% | 80.7 | 1,663,831 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 82.71 per share. | 17 Jan 2023 | 346 | 1,741,539 (10%) | 0% | 82.7 | 28,619 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.41 per share. | 17 Jan 2023 | 1,186 | 1,741,885 (10%) | 0% | 81.4 | 96,548 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.41 per share. | 17 Jan 2023 | 1,186 | 1,680,460 (9%) | 0% | 81.4 | 96,548 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.41 per share. | 17 Jan 2023 | 1,186 | 1,741,885 (10%) | 0% | 81.4 | 96,548 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.70 per share. | 17 Jan 2023 | 20,617 | 1,743,071 (10%) | 0% | 80.7 | 1,663,831 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 82.72 per share. | 17 Jan 2023 | 345 | 1,680,115 (9%) | 0% | 82.7 | 28,537 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.70 per share. | 17 Jan 2023 | 20,617 | 1,681,646 (9%) | 0% | 80.7 | 1,663,831 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.56 per share. | 17 Jan 2023 | 803 | 1,738,688 (10%) | 0% | 81.6 | 65,492 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.75 per share. | 17 Jan 2023 | 2,048 | 1,739,491 (10%) | 0% | 80.8 | 165,382 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.56 per share. | 17 Jan 2023 | 804 | 1,677,263 (9%) | 0% | 81.6 | 65,574 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.75 per share. | 17 Jan 2023 | 2,048 | 1,678,067 (9%) | 0% | 80.8 | 165,382 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 82.71 per share. | 17 Jan 2023 | 346 | 1,741,539 (10%) | 0% | 82.7 | 28,619 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.09 per share. | 04 Jan 2023 | 3,938 | 1,702,263 (9%) | 0% | 80.1 | 315,385 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.08 per share. | 04 Jan 2023 | 3,748 | 1,763,688 (10%) | 0% | 80.1 | 300,140 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.08 per share. | 04 Jan 2023 | 3,748 | 1,763,688 (10%) | 0% | 80.1 | 300,140 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.09 per share. | 04 Jan 2023 | 3,938 | 1,702,263 (9%) | 0% | 80.1 | 315,385 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.28 per share. | 29 Dec 2022 | 7,447 | 1,769,699 (10%) | 0% | 80.3 | 597,849 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.33 per share. | 29 Dec 2022 | 1,700 | 1,706,201 (9%) | 0% | 80.3 | 136,554 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.33 per share. | 29 Dec 2022 | 1,700 | 1,767,436 (10%) | 0% | 80.3 | 136,567 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.10 per share. | 29 Dec 2022 | 528 | 1,707,901 (9%) | 0% | 81.1 | 42,822 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.30 per share. | 29 Dec 2022 | 7,484 | 1,708,429 (9%) | 0% | 80.3 | 600,957 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.10 per share. | 29 Dec 2022 | 563 | 1,769,136 (10%) | 0% | 81.1 | 45,662 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.30 per share. | 29 Dec 2022 | 7,484 | 1,708,429 (9%) | 0% | 80.3 | 600,957 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.33 per share. | 29 Dec 2022 | 1,700 | 1,767,436 (10%) | 0% | 80.3 | 136,567 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.33 per share. | 29 Dec 2022 | 1,700 | 1,706,201 (9%) | 0% | 80.3 | 136,554 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.10 per share. | 29 Dec 2022 | 563 | 1,769,136 (10%) | 0% | 81.1 | 45,662 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.28 per share. | 29 Dec 2022 | 7,447 | 1,769,699 (10%) | 0% | 80.3 | 597,849 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.10 per share. | 29 Dec 2022 | 528 | 1,707,901 (9%) | 0% | 81.1 | 42,822 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.10 per share. | 16 Dec 2022 | 10,527 | 1,715,913 (9%) | 0% | 80.1 | 843,170 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.10 per share. | 16 Dec 2022 | 10,572 | 1,777,146 (10%) | 0% | 80.1 | 846,816 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.10 per share. | 16 Dec 2022 | 10,527 | 1,715,913 (9%) | 0% | 80.1 | 843,170 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.10 per share. | 16 Dec 2022 | 10,572 | 1,777,146 (10%) | 0% | 80.1 | 846,816 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 23 Nov 2022 | 4 | 1,787,718 (10%) | 0% | 80 | 320 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 23 Nov 2022 | 4 | 1,787,718 (10%) | 0% | 80 | 320 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.04 per share. | 08 Nov 2022 | 823 | 1,726,440 (9%) | 0% | 80.0 | 65,871 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.05 per share. | 08 Nov 2022 | 966 | 1,787,722 (10%) | 0% | 80.1 | 77,331 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.04 per share. | 08 Nov 2022 | 823 | 1,726,440 (9%) | 0% | 80.0 | 65,871 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.05 per share. | 08 Nov 2022 | 966 | 1,787,722 (10%) | 0% | 80.1 | 77,331 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.62 per share. | 05 Aug 2022 | 13,432 | 1,729,839 (9%) | 0% | 81.6 | 1,096,316 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.24 per share. | 05 Aug 2022 | 9,088 | 1,804,600 (10%) | 0% | 80.2 | 729,208 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.61 per share. | 05 Aug 2022 | 13,058 | 1,791,542 (10%) | 0% | 81.6 | 1,065,639 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.22 per share. | 05 Aug 2022 | 8,992 | 1,743,271 (10%) | 0% | 80.2 | 721,332 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 82.19 per share. | 05 Aug 2022 | 2,854 | 1,788,688 (10%) | 0% | 82.2 | 234,576 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 82.20 per share. | 05 Aug 2022 | 2,576 | 1,727,263 (9%) | 0% | 82.2 | 211,755 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 82.20 per share. | 05 Aug 2022 | 2,576 | 1,727,263 (9%) | 0% | 82.2 | 211,755 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.24 per share. | 05 Aug 2022 | 9,088 | 1,804,600 (10%) | 0% | 80.2 | 729,208 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.62 per share. | 05 Aug 2022 | 13,432 | 1,729,839 (9%) | 0% | 81.6 | 1,096,316 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 80.22 per share. | 05 Aug 2022 | 8,992 | 1,743,271 (10%) | 0% | 80.2 | 721,332 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 81.61 per share. | 05 Aug 2022 | 13,058 | 1,791,542 (10%) | 0% | 81.6 | 1,065,639 | Common Stock |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 82.19 per share. | 05 Aug 2022 | 2,854 | 1,788,688 (10%) | 0% | 82.2 | 234,576 | Common Stock |
| Daniel S. Janney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Dino A. Rossi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Julian S. Gangolli | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Christopher Mason | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Everett Rand Sutherland | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2022 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Andrew C. Orth | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 62.50 per share. | 26 Feb 2022 | 4,655 | 1,813,688 (10%) | 0% | 62.5 | 290,938 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2022 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2022 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Suma M. Krishnan | Director, President, R&D, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 62.50 per share. | 26 Feb 2022 | 3,282 | 1,752,263 (10%) | 0% | 62.5 | 205,125 | Common Stock |
| Kathryn A. Romano | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2022 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Kathryn A. Romano | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 62.50 per share. | 26 Feb 2022 | 1,472 | 18,128 (0%) | 0% | 62.5 | 92,000 | Common Stock |
| Jing Marantz | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2022 | 205,000 | 205,000 | - | - | Stock Option (Right to Buy) | |
| Everett Rand Sutherland | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2022 | 13,600 | 13,600 | - | - | Stock Option (Right to Buy) | |
| Daniel S. Janney | Director | Sale of securities on an exchange or to another person at price $ 70.50 per share. | 10 Dec 2021 | 100,000 | 266,362 (1%) | 0% | 70.5 | 7,050,000 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 70.50 per share. | 10 Dec 2021 | 100,000 | 50,000 (0%) | 0% | 70.5 | 7,050,000 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 70.50 per share. | 10 Dec 2021 | 100,000 | 50,000 (0%) | 0% | 70.5 | 7,050,000 | Common Stock |
| Daniel S. Janney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2021 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Dino A. Rossi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2021 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Julian S. Gangolli | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2021 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Jing Marantz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2021 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Christopher Mason | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2021 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 40,800 | 1,927,262 (11%) | 0% | - | Common Stock | |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 61,200 | 61,200 | - | - | Stock Option (Right to Buy) | |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 42,600 | 42,600 | - | - | Stock Option (Right to Buy) | |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 28,400 | 1,864,464 (10%) | 0% | - | Common Stock | |
| Kathryn A. Romano | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 29,400 | 29,400 | - | - | Stock Option (Right to Buy) | |
| Kathryn A. Romano | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 19,600 | 19,600 (0%) | 0% | - | Common Stock | |
| Jing Marantz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2021 | 13,600 | 13,600 | - | - | Stock Option (Right to Buy) | |
| Christopher Mason | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2021 | 13,600 | 13,600 | - | - | Stock Option (Right to Buy) | |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 46.21 per share. | 15 Sep 2020 | 14,435 | 1,871,629 (10%) | 0% | 46.2 | 667,031 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 47.29 per share. | 15 Sep 2020 | 1,126 | 1,836,064 (10%) | 0% | 47.3 | 53,248 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 46.63 per share. | 15 Sep 2020 | 7,437 | 1,837,190 (10%) | 0% | 46.6 | 346,813 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 46.09 per share. | 15 Sep 2020 | 10,594 | 1,844,627 (10%) | 0% | 46.1 | 488,297 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 46.85 per share. | 15 Sep 2020 | 5,142 | 1,855,221 (10%) | 0% | 46.8 | 240,896 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 46.24 per share. | 15 Sep 2020 | 9,749 | 1,860,363 (10%) | 0% | 46.2 | 450,821 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 47.15 per share. | 15 Sep 2020 | 1,517 | 1,870,112 (10%) | 0% | 47.1 | 71,523 | Common Stock |
| Daniel S. Janney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2020 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Dino A. Rossi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2020 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Julian S. Gangolli | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2020 | 6,800 | 6,800 | - | - | Stock Option (Right to Buy) | |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 42.24 per share. | 15 Jun 2020 | 8,652 | 1,919,834 (11%) | 0% | 42.2 | 365,427 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 45.07 per share. | 15 Jun 2020 | 11,719 | 1,886,064 (10%) | 0% | 45.1 | 528,182 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 44.56 per share. | 15 Jun 2020 | 11,311 | 1,897,783 (10%) | 0% | 44.6 | 504,058 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 43.21 per share. | 15 Jun 2020 | 10,740 | 1,909,094 (11%) | 0% | 43.2 | 464,070 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 41.31 per share. | 15 Jun 2020 | 7,578 | 1,928,486 (11%) | 0% | 41.3 | 313,038 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 56.84 per share. | 15 May 2020 | 6,784 | 1,899,939 (10%) | 0% | 56.8 | 385,589 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 57.43 per share. | 15 May 2020 | 3,842 | 1,932,620 (11%) | 0% | 57.4 | 220,639 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 58.09 per share. | 15 May 2020 | 12,445 | 1,920,175 (11%) | 0% | 58.1 | 722,873 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 59.03 per share. | 15 May 2020 | 10,552 | 1,909,623 (11%) | 0% | 59.0 | 622,874 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 55.99 per share. | 15 May 2020 | 2,900 | 1,906,723 (11%) | 0% | 56.0 | 162,357 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 57.63 per share. | 15 May 2020 | 5,371 | 1,894,568 (10%) | 0% | 57.6 | 309,532 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 59.11 per share. | 15 May 2020 | 1,805 | 1,892,763 (10%) | 0% | 59.1 | 106,699 | Common Stock |
| Krish S. Krishnan | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 59.73 per share. | 15 May 2020 | 6,301 | 1,886,462 (10%) | 0% | 59.7 | 376,345 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 40.14 per share. | 16 Mar 2020 | 2,559 | 1,948,903 (11%) | 0% | 40.1 | 102,714 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 40.20 per share. | 16 Mar 2020 | 659 | 1,936,064 (11%) | 0% | 40.2 | 26,493 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 42.00 per share. | 16 Mar 2020 | 4 | 1,936,723 (11%) | 0% | 42 | 168 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 41.27 per share. | 16 Mar 2020 | 1,396 | 1,936,727 (11%) | 0% | 41.3 | 57,607 | Common Stock |
| Suma M. Krishnan | Director, Chief Operating Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 40.49 per share. | 16 Mar 2020 | 10,780 | 1,938,123 (11%) | 0% | 40.5 | 436,429 | Common Stock |