40,714
XNAS Volume
High volume today
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 10.08 per share. | 21 Feb 2025 | 303 | 49,129 | - | 10.1 | 3,053 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 10.08 per share. | 21 Feb 2025 | 106 | 6,517 | - | 10.1 | 1,068 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 10.07 per share. | 21 Feb 2025 | 96 | 2,832 | - | 10.1 | 967 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 9.92 per share. | 23 Jan 2025 | 13 | 49,432 | - | 9.9 | 129 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 9.46 per share. | 23 Jan 2025 | 116 | 49,445 | - | 9.5 | 1,097 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 10.00 per share. | 23 Jan 2025 | 5 | 6,623 | - | 10 | 50 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 9.45 per share. | 23 Jan 2025 | 47 | 6,628 | - | 9.4 | 444 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 10.00 per share. | 23 Jan 2025 | 4 | 2,928 | - | 10 | 40 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 9.47 per share. | 23 Jan 2025 | 32 | 2,932 | - | 9.5 | 303 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.44 per share. | 10 Jan 2025 | 979 | 1,139,915 | - | 0.4 | 431 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.44 per share. | 10 Jan 2025 | 409 | 153,541 | - | 0.4 | 180 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.44 per share. | 10 Jan 2025 | 332 | 68,174 | - | 0.4 | 146 | Common Stock |
| Edward Miller | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 11 Dec 2024 | 57,549 | 346,348 | - | 0 | Common Stock | |
| Edward Miller | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 11 Dec 2024 | 57,549 | 153,950 | - | 0 | Common Stock | |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.55 per share. | 19 Nov 2024 | 3,186 | 1,140,894 | - | 0.5 | 1,748 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.55 per share. | 19 Nov 2024 | 432 | 211,499 | - | 0.5 | 237 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.55 per share. | 19 Nov 2024 | 554 | 68,506 | - | 0.5 | 304 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.55 per share. | 19 Nov 2024 | 8,706 | 723,363 | - | 0.5 | 4,775 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.86 per share. | 05 Nov 2024 | 5,136 | 1,144,080 | - | 0.9 | 4,442 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.86 per share. | 05 Nov 2024 | 2,272 | 211,931 | - | 0.9 | 1,965 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.86 per share. | 05 Nov 2024 | 1,655 | 69,060 | - | 0.9 | 1,431 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.86 per share. | 05 Nov 2024 | 10,609 | 732,069 | - | 0.9 | 9,176 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.78 per share. | 21 Oct 2024 | 1,546 | 1,151,098 | - | 0.8 | 1,204 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.77 per share. | 21 Oct 2024 | 1,882 | 1,149,216 | - | 0.8 | 1,445 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.77 per share. | 21 Oct 2024 | 766 | 214,203 | - | 0.8 | 588 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.78 per share. | 21 Oct 2024 | 635 | 214,969 | - | 0.8 | 495 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.77 per share. | 21 Oct 2024 | 486 | 70,715 | - | 0.8 | 373 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.78 per share. | 21 Oct 2024 | 479 | 71,201 | - | 0.8 | 373 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.78 per share. | 21 Oct 2024 | 9,752 | 742,678 | - | 0.8 | 7,597 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.81 per share. | 03 Oct 2024 | 940 | 1,152,644 | - | 0.8 | 766 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.81 per share. | 03 Oct 2024 | 377 | 215,604 | - | 0.8 | 307 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.81 per share. | 03 Oct 2024 | 301 | 71,680 | - | 0.8 | 245 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.81 per share. | 03 Oct 2024 | 1,493 | 752,430 | - | 0.8 | 1,216 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.74 per share. | 20 Aug 2024 | 5,390 | 753,923 | - | 0.7 | 3,996 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.76 per share. | 19 Aug 2024 | 3,159 | 1,153,584 | - | 0.8 | 2,399 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.76 per share. | 19 Aug 2024 | 422 | 215,981 | - | 0.8 | 321 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.76 per share. | 19 Aug 2024 | 544 | 71,981 | - | 0.8 | 413 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.76 per share. | 19 Aug 2024 | 3,091 | 759,313 | - | 0.8 | 2,348 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.73 per share. | 05 Aug 2024 | 5,251 | 1,156,743 | - | 0.7 | 3,858 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.73 per share. | 05 Aug 2024 | 2,323 | 216,403 | - | 0.7 | 1,707 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.73 per share. | 05 Aug 2024 | 1,692 | 72,525 | - | 0.7 | 1,243 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.73 per share. | 05 Aug 2024 | 10,847 | 762,404 | - | 0.7 | 7,970 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.74 per share. | 19 Jul 2024 | 1,858 | 1,161,994 | - | 0.7 | 1,373 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 19 Jul 2024 | 1,542 | 1,163,852 | - | 0.8 | 1,157 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 19 Jul 2024 | 634 | 219,483 | - | 0.8 | 476 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.74 per share. | 19 Jul 2024 | 757 | 218,726 | - | 0.7 | 560 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 19 Jul 2024 | 479 | 74,698 | - | 0.7 | 359 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.74 per share. | 19 Jul 2024 | 481 | 74,217 | - | 0.7 | 356 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 19 Jul 2024 | 9,731 | 773,251 | - | 0.8 | 7,299 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.72 per share. | 02 Jul 2024 | 939 | 1,165,394 | - | 0.7 | 676 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.72 per share. | 02 Jul 2024 | 379 | 220,117 | - | 0.7 | 273 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.72 per share. | 02 Jul 2024 | 304 | 75,177 | - | 0.7 | 219 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.72 per share. | 02 Jul 2024 | 1,489 | 782,982 | - | 0.7 | 1,072 | Common Stock |
| David L. Hallal | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 35,000 | 2,143,662 | - | 0 | Common Stock | |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 35,000 | 100,197 | - | 0 | Common Stock | |
| Jeffrey S. Bornstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 35,000 | 110,197 | - | 0 | Common Stock | |
| Shawn Cline Tomasello | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 35,000 | 70,000 | - | 0 | Common Stock | |
| Juan Vera | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 35,000 | 2,409,928 | - | 0 | Common Stock | |
| Malcolm Brenner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 35,000 | 100,197 | - | 0 | Common Stock | |
| Derek N. Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 35,000 | 70,000 | - | 0 | Common Stock | |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.79 per share. | 21 May 2024 | 5,149 | 784,471 | - | 0.8 | 4,080 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 17 May 2024 | 3,143 | 1,129,996 | - | 0.7 | 2,355 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 17 May 2024 | 420 | 220,496 | - | 0.8 | 315 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 17 May 2024 | 541 | 75,481 | - | 0.7 | 405 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 17 May 2024 | 3,075 | 789,620 | - | 0.7 | 2,304 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.80 per share. | 03 May 2024 | 4,957 | 1,133,139 | - | 0.8 | 3,946 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.80 per share. | 03 May 2024 | 2,311 | 220,916 | - | 0.8 | 1,840 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.80 per share. | 03 May 2024 | 1,597 | 76,022 | - | 0.8 | 1,271 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.80 per share. | 03 May 2024 | 10,240 | 792,695 | - | 0.8 | 8,151 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 19 Apr 2024 | 1,521 | 1,139,953 | - | 0.8 | 1,142 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 19 Apr 2024 | 1,857 | 1,138,096 | - | 0.8 | 1,393 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 19 Apr 2024 | 757 | 223,227 | - | 0.8 | 568 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 19 Apr 2024 | 626 | 223,984 | - | 0.8 | 470 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 19 Apr 2024 | 480 | 77,619 | - | 0.8 | 360 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 19 Apr 2024 | 473 | 78,099 | - | 0.8 | 355 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.75 per share. | 19 Apr 2024 | 9,601 | 802,935 | - | 0.8 | 7,207 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.77 per share. | 02 Apr 2024 | 885 | 1,141,474 | - | 0.8 | 683 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.77 per share. | 02 Apr 2024 | 368 | 224,610 | - | 0.8 | 284 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.77 per share. | 02 Apr 2024 | 281 | 78,572 | - | 0.8 | 217 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.77 per share. | 02 Apr 2024 | 1,533 | 812,536 | - | 0.8 | 1,183 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.70 per share. | 20 Feb 2024 | 385 | 224,978 | - | 0.7 | 268 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.70 per share. | 20 Feb 2024 | 2,893 | 1,142,359 | - | 0.7 | 2,011 | Common Stock |
| Brainard M. Diana | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.70 per share. | 20 Feb 2024 | 3,097 | 819,224 | - | 0.7 | 2,153 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.71 per share. | 20 Feb 2024 | 5,155 | 814,069 | - | 0.7 | 3,650 | Common Stock |
| Hagen Brett R. | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.69 per share. | 20 Feb 2024 | 494 | 78,853 | - | 0.7 | 343 | Common Stock |
| R. Hagen Brett | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.67 per share. | 08 Feb 2024 | 11,150 | 79,347 | - | 0.7 | 7,494 | Common Stock |
| Diana Brainard M. | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.67 per share. | 05 Feb 2024 | 41,421 | 822,321 | - | 0.7 | 27,752 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.67 per share. | 05 Feb 2024 | 18,331 | 1,145,252 | - | 0.7 | 12,282 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.67 per share. | 05 Feb 2024 | 8,869 | 225,363 | - | 0.7 | 5,942 | Common Stock |
| Hagen R. Brett | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.67 per share. | 05 Feb 2024 | 5,792 | 90,497 | - | 0.7 | 3,881 | Common Stock |
| Hagen R. Brett | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.67 per share. | 23 Jan 2024 | 901 | 96,289 | - | 0.7 | 604 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.67 per share. | 23 Jan 2024 | 3,205 | 1,163,583 | - | 0.7 | 2,150 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.67 per share. | 23 Jan 2024 | 9,500 | 863,742 | - | 0.7 | 6,369 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.67 per share. | 23 Jan 2024 | 1,302 | 234,232 | - | 0.7 | 873 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 0.64 per share. | 04 Jan 2024 | 424 | 235,534 | - | 0.6 | 271 | Common Stock |
| Hagen R. Brett | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.64 per share. | 04 Jan 2024 | 310 | 97,190 | - | 0.6 | 198 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.64 per share. | 04 Jan 2024 | 961 | 1,166,788 | - | 0.6 | 614 | Common Stock |
| M. Diana Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.64 per share. | 04 Jan 2024 | 1,664 | 873,242 | - | 0.6 | 1,063 | Common Stock |
| Brett Hagen R. | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 0.74 per share. | 27 Dec 2023 | 28,335 | 97,500 | - | 0.7 | 20,838 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 2.50 per share. | 17 Aug 2023 | 10,516 | 1,173,701 | - | 2.5 | 26,243 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 2.50 per share. | 17 Aug 2023 | 1,653 | 127,175 | - | 2.5 | 4,125 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 2.50 per share. | 17 Aug 2023 | 11,361 | 895,938 | - | 2.5 | 28,351 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 2.79 per share. | 17 Aug 2023 | 4,055 | 891,883 | - | 2.8 | 11,313 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.35 per share. | 19 Jul 2023 | 1,437 | 1,184,217 | - | 3.3 | 4,810 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.56 per share. | 19 Jul 2023 | 1,198 | 1,185,654 | - | 3.6 | 4,267 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 3.56 per share. | 19 Jul 2023 | 342 | 129,170 | - | 3.6 | 1,218 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 3.35 per share. | 19 Jul 2023 | 342 | 128,828 | - | 3.3 | 1,145 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 3.56 per share. | 19 Jul 2023 | 8,342 | 907,299 | - | 3.6 | 29,710 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.05 per share. | 05 Jul 2023 | 2,983 | 1,186,852 | - | 3.0 | 9,084 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 3.05 per share. | 05 Jul 2023 | 5,275 | 915,641 | - | 3.0 | 16,063 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 5.64 per share. | 09 Jun 2023 | 5,045 | 129,512 | - | 5.6 | 28,453 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 4.21 per share. | 18 May 2023 | 4,536 | 916,628 | - | 4.2 | 19,115 | Common Stock |
| David Hallal | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 35,000 | 2,108,662 | - | 0 | Common Stock | |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 35,000 | 65,197 | - | 0 | Common Stock | |
| Jeffrey S. Bornstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 35,000 | 75,197 | - | 0 | Common Stock | |
| Shawn Cline Tomasello | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 35,000 | 35,000 | - | 0 | Common Stock | |
| Juan Vera | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 35,000 | 2,374,928 | - | 0 | Common Stock | |
| Malcolm Brenner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 35,000 | 65,197 | - | 0 | Common Stock | |
| Derek N. Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 35,000 | 35,000 | - | 0 | Common Stock | |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.63 per share. | 19 Apr 2023 | 1,466 | 1,185,055 | - | 3.6 | 5,315 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.71 per share. | 19 Apr 2023 | 1,217 | 1,186,521 | - | 3.7 | 4,513 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 3.71 per share. | 19 Apr 2023 | 348 | 134,906 | - | 3.7 | 1,291 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 3.62 per share. | 19 Apr 2023 | 349 | 134,557 | - | 3.6 | 1,265 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 3.71 per share. | 19 Apr 2023 | 8,408 | 921,164 | - | 3.7 | 31,183 | Common Stock |
| Derek N. Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 45,000 | 45,000 | - | - | Stock Option (Right to Buy) | |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 6.63 per share. | 21 Feb 2023 | 5,122 | 929,572 | - | 6.6 | 33,935 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 292,500 | 1,012,362 | - | - | Stock Option (Right to Buy) | |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 157,500 | 1,187,738 | - | 0 | Common Stock | |
| Edward Miller | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 162,500 | 497,844 | - | - | Stock Option (Right to Buy) | |
| Edward Miller | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 87,500 | 235,958 | - | 0 | Common Stock | |
| Brett R. Hagen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 61,250 | 135,254 | - | 0 | Common Stock | |
| Brett R. Hagen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 113,750 | 251,708 | - | - | Stock Option (Right to Buy) | |
| Diana M. Brainard | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 617,500 | 1,836,875 | - | - | Stock Option (Right to Buy) | |
| Diana M. Brainard | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Feb 2023 | 332,500 | 934,964 | - | 0 | Common Stock | |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 5.14 per share. | 19 Jan 2023 | 1,426 | 1,030,238 | - | 5.1 | 7,335 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 5.08 per share. | 19 Jan 2023 | 5,111 | 1,031,664 | - | 5.1 | 25,952 | Common Stock |
| Edward Miller | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Jan 2023 | 98,346 | 288,799 | - | 0 | Common Stock | |
| Edward Miller | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Jan 2023 | 98,346 | 151,031 | - | 0 | Common Stock | |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 5.14 per share. | 19 Jan 2023 | 541 | 148,458 | - | 5.1 | 2,783 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 5.08 per share. | 19 Jan 2023 | 2,032 | 148,999 | - | 5.1 | 10,318 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 5.08 per share. | 19 Jan 2023 | 1,557 | 74,342 | - | 5.1 | 7,906 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 5.14 per share. | 19 Jan 2023 | 338 | 74,004 | - | 5.1 | 1,739 | Common Stock |
| Diana M. Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 5.08 per share. | 19 Jan 2023 | 34,435 | 601,607 | - | 5.1 | 174,851 | Common Stock |
| Diana Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 7.27 per share. | 18 Nov 2022 | 4,515 | 633,033 | - | 7.3 | 32,810 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 7.50 per share. | 16 Nov 2022 | 16,074 | 333,726 | - | 7.5 | 120,528 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 8.91 per share. | 14 Nov 2022 | 2,358 | 190,453 | - | 8.9 | 21,018 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 8.20 per share. | 11 Nov 2022 | 36,592 | 349,800 | - | 8.2 | 299,904 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 8.18 per share. | 10 Nov 2022 | 18,011 | 75,899 | - | 8.2 | 147,258 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 8.00 per share. | 10 Nov 2022 | 5,989 | 93,910 | - | 8.0 | 47,925 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 8.00 per share. | 08 Nov 2022 | 13,109 | 386,392 | - | 8.0 | 104,901 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 8.00 per share. | 08 Nov 2022 | 299 | 399,501 | - | 8 | 2,392 | Common Stock |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 9.36 per share. | 20 Oct 2022 | 1,449 | 1,036,775 | - | 9.4 | 13,564 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 9.36 per share. | 20 Oct 2022 | 553 | 249,377 | - | 9.4 | 5,176 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 9.36 per share. | 20 Oct 2022 | 345 | 113,233 | - | 9.4 | 3,229 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 9.36 per share. | 20 Oct 2022 | 1,070 | 399,800 | - | 9.4 | 10,016 | Common Stock |
| Ercem Atillasoy | See Remarks | Sale of securities on an exchange or to another person at price $ 8.48 per share. | 20 Oct 2022 | 1,527 | 131,372 | - | 8.5 | 12,956 | Common Stock |
| Ercem Atillasoy | See Remarks | Sale of securities on an exchange or to another person at price $ 9.36 per share. | 20 Oct 2022 | 568 | 132,899 | - | 9.4 | 5,317 | Common Stock |
| David Hallal | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 7.35 per share. | 29 Sep 2022 | 400,000 | 720,965 | - | 7.4 | 2,940,920 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 7.89 per share. | 02 Sep 2022 | 493 | 400,870 | - | 7.9 | 3,889 | Common Stock |
| Diana Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 7.76 per share. | 18 Aug 2022 | 4,564 | 637,548 | - | 7.8 | 35,429 | Common Stock |
| Vikas Sinha | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2022 | 100,000 | 1,038,224 | - | 0 | Common Stock | |
| Edward Miller | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2022 | 15,000 | 249,930 | - | 0 | Common Stock | |
| Brett R. Hagen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2022 | 20,000 | 113,578 | - | 0 | Common Stock | |
| Jeroen B. Van Beek | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2022 | 15,000 | 401,363 | - | 0 | Common Stock | |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 8.30 per share. | 16 Aug 2022 | 15,590 | 386,363 | - | 8.3 | 129,473 | Common Stock |
| Ann Leen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2022 | 15,000 | 43,000 | - | 0 | Common Stock | |
| Diana Brainard | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2022 | 100,000 | 642,112 | - | 0 | Common Stock | |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 4.61 per share. | 28 Jul 2022 | 3,253,796 | 16,674,766 | - | 4.6 | 15,000,000 | Common Stock |
| David Hallal | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 4.61 per share. | 28 Jul 2022 | 3,253,796 | 16,674,766 | - | 4.6 | 15,000,000 | Common Stock |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 4.61 per share. | 28 Jul 2022 | 3,253,796 | 16,674,766 | - | 4.6 | 15,000,000 | Common Stock |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 4.61 per share. | 28 Jul 2022 | 867,678 | 867,678 | - | 4.6 | 3,999,996 | Common Stock |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 4.61 per share. | 28 Jul 2022 | 1,393,874 | 4,193,874 | - | 4.6 | 6,425,759 | Common Stock |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 4.61 per share. | 28 Jul 2022 | 1,626,898 | 2,038,583 | - | 4.6 | 7,500,000 | Common Stock |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 4.61 per share. | 28 Jul 2022 | 325,379 | 668,072 | - | 4.6 | 1,499,997 | Common Stock |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 4.61 per share. | 28 Jul 2022 | 684,622 | 2,059,884 | - | 4.6 | 3,156,107 | Common Stock |
| David Hallal | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 5.33 per share. | 21 Jul 2022 | 4,227 | 2,073,662 | - | 5.3 | 22,528 | Common Stock |
| Ercem Atillasoy | See Remarks | Sale of securities on an exchange or to another person at price $ 5.38 per share. | 21 Jul 2022 | 1,533 | 133,467 | - | 5.4 | 8,245 | Common Stock |
| Vikas Sinha | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 5.21 per share. | 20 Jul 2022 | 1,432 | 938,224 | - | 5.2 | 7,467 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 5.21 per share. | 20 Jul 2022 | 1,058 | 401,953 | - | 5.2 | 5,517 | Common Stock |
| Ercem Atillasoy | See Remarks | Sale of securities on an exchange or to another person at price $ 5.21 per share. | 20 Jul 2022 | 563 | 135,000 | - | 5.2 | 2,936 | Common Stock |
| Vikas Sinha | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 29,400 | 939,656 | - | 0 | Common Stock | |
| Vikas Sinha | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 54,600 | 54,600 | - | - | Stock Option (Right to Buy) | |
| Edward Miller | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 14,000 | 234,930 | - | 0 | Common Stock | |
| Edward Miller | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 26,000 | 26,000 | - | - | Stock Option (Right to Buy) | |
| Brett R. Hagen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 10,500 | 93,578 | - | 0 | Common Stock | |
| Brett R. Hagen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 19,500 | 19,500 | - | - | Stock Option (Right to Buy) | |
| Ercem Atillasoy | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 14,000 | 135,563 | - | 0 | Common Stock | |
| Ercem Atillasoy | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 26,000 | 26,000 | - | - | Stock Option (Right to Buy) | |
| Diana Brainard | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 48,125 | 542,112 | - | 0 | Common Stock | |
| Diana Brainard | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2022 | 89,375 | 89,375 | - | - | Stock Option (Right to Buy) | |
| David Hallal | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 3.67 per share. | 03 Jun 2022 | 65,725 | 2,077,889 | - | 3.7 | 241,106 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2022 | 26,000 | 26,000 | - | - | Stock Option (Right to Buy) | |
| Jeroen B. Van Beek | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2022 | 14,000 | 403,011 | - | 0 | Common Stock | |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 3.63 per share. | 03 Jun 2022 | 515 | 389,011 | - | 3.6 | 1,871 | Common Stock |
| Diana Brainard | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 4.33 per share. | 18 May 2022 | 29,135 | 492,165 | - | 4.3 | 126,257 | Common Stock |
| David Hallal | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 27,500 | 27,500 | - | - | Stock Option (Right to Buy) | |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 27,500 | 27,500 | - | - | Stock Option (Right to Buy) | |
| Jeffrey S. Bornstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 27,500 | 27,500 | - | - | Stock Option (Right to Buy) | |
| Shawn Cline Tomasello | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 27,500 | 27,500 | - | - | Stock Option (Right to Buy) | |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 4.40 per share. | 17 May 2022 | 15,262 | 389,526 | - | 4.4 | 67,167 | Common Stock |
| Juan Vera | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 27,500 | 27,500 | - | - | Stock Option (Right to Buy) | |
| Malcolm Brenner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2022 | 27,500 | 27,500 | - | - | Stock Option (Right to Buy) | |
| Jeffrey S. Bornstein | Director | Purchase of securities on an exchange or from another person at price $ 4.64 per share. | 26 Apr 2022 | 5,000 | 40,197 | - | 4.6 | 23,197 | Common Stock |
| David Hallal | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 5.87 per share. | 21 Apr 2022 | 4,227 | 2,143,614 | - | 5.9 | 24,812 | Common Stock |
| Vikas Sinha | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 6.68 per share. | 20 Apr 2022 | 1,162 | 906,633 | - | 6.7 | 7,767 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 6.68 per share. | 20 Apr 2022 | 276 | 80,368 | - | 6.7 | 1,845 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 6.68 per share. | 20 Apr 2022 | 852 | 404,788 | - | 6.7 | 5,695 | Common Stock |
| Ercem Atillasoy | See Remarks | Sale of securities on an exchange or to another person at price $ 5.86 per share. | 20 Apr 2022 | 1,587 | 121,563 | - | 5.9 | 9,301 | Common Stock |
| Ercem Atillasoy | See Remarks | Sale of securities on an exchange or to another person at price $ 6.68 per share. | 20 Apr 2022 | 453 | 123,150 | - | 6.7 | 3,028 | Common Stock |
| Shawn Cline Tomasello | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2022 | 45,000 | 45,000 | - | - | Stock Option (Right to Buy) | |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 9.01 per share. | 02 Mar 2022 | 516 | 382,384 | - | 9.0 | 4,651 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 8.32 per share. | 16 Feb 2022 | 15,322 | 382,900 | - | 8.3 | 127,525 | Common Stock |
| Jeffrey S. Bornstein | Director | Purchase of securities on an exchange or from another person at price $ 8.87 per share. | 10 Feb 2022 | 5,000 | 35,197 | - | 8.9 | 44,350 | Common Stock |
| Ercem Atillasoy | See Remarks | Sale of securities on an exchange or to another person at price $ 8.24 per share. | 25 Jan 2022 | 4,639 | 100,347 | - | 8.2 | 38,248 | Common Stock |
| David Hallal | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 8.01 per share. | 24 Jan 2022 | 17,100 | 2,213,566 | - | 8.0 | 136,889 | Common Stock |
| Vikas Sinha | Director, See Remarks | Sale of securities on an exchange or to another person at price $ 8.75 per share. | 20 Jan 2022 | 6,450 | 858,957 | - | 8.8 | 56,454 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 8.75 per share. | 20 Jan 2022 | 1,563 | 63,202 | - | 8.8 | 13,680 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 8.75 per share. | 20 Jan 2022 | 4,656 | 398,222 | - | 8.8 | 40,752 | Common Stock |
| Vikas Sinha | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 119,162 | 119,162 | - | - | Stock Option (Right to Buy) | |
| Vikas Sinha | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 48,838 | 907,795 | - | 0 | Common Stock | |
| Edward Miller | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 56,744 | 56,744 | - | - | Stock Option (Right to Buy) | |
| Edward Miller | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 23,256 | 217,307 | - | 0 | Common Stock | |
| Brett R. Hagen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 42,558 | 42,558 | - | - | Stock Option (Right to Buy) | |
| Brett R. Hagen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 17,442 | 80,644 | - | 0 | Common Stock | |
| Jeroen B. Van Beek | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 23,256 | 405,640 | - | 0 | Common Stock | |
| Jeroen B. Van Beek | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 56,744 | 56,744 | - | - | Stock Option (Right to Buy) | |
| Ann Leen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 81,250 | 473,594 | - | - | Stock Option (Right to Buy) | |
| Ann Leen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 43,750 | 124,006 | - | 0 | Common Stock | |
| Ann Leen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 56,744 | 366,344 | - | - | Stock Option (Right to Buy) | |
| Ann Leen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 26,000 | 392,344 | - | - | Stock Option (Right to Buy) | |
| Ann Leen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 23,256 | 51,256 | - | 0 | Common Stock | |
| Ann Leen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 14,000 | 65,256 | - | 0 | Common Stock | |
| Ercem Atillasoy | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 23,256 | 123,603 | - | 0 | Common Stock | |
| Ercem Atillasoy | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 56,744 | 56,744 | - | - | Stock Option (Right to Buy) | |
| Diana Brainard | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 315,000 | 521,300 | - | 0 | Common Stock | |
| Diana Brainard | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 585,000 | 585,000 | - | - | Stock Option (Right to Buy) | |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 21.13 per share. | 16 Nov 2021 | 15,203 | 403,392 | - | 21.1 | 321,262 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 22.26 per share. | 12 Nov 2021 | 14,266 | 2,294,876 | - | 22.3 | 317,628 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 21.76 per share. | 12 Nov 2021 | 100 | 2,288,154 | - | 21.8 | 2,176 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 21.92 per share. | 12 Nov 2021 | 6,122 | 2,288,254 | - | 21.9 | 134,167 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 23.18 per share. | 12 Nov 2021 | 500 | 2,294,376 | - | 23.2 | 11,588 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.77 per share. | 10 Nov 2021 | 120 | 342,693 | - | 24.8 | 2,972 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.76 per share. | 10 Nov 2021 | 680 | 1,375,262 | - | 24.8 | 16,840 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.81 per share. | 05 Nov 2021 | 1,257 | 343,385 | - | 24.8 | 31,180 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.79 per share. | 05 Nov 2021 | 572 | 342,813 | - | 24.8 | 14,179 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.79 per share. | 05 Nov 2021 | 3,243 | 1,375,942 | - | 24.8 | 80,388 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.80 per share. | 05 Nov 2021 | 7,124 | 1,379,185 | - | 24.8 | 176,709 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.78 per share. | 27 Oct 2021 | 330 | 344,642 | - | 24.8 | 8,177 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.78 per share. | 27 Oct 2021 | 1,870 | 1,386,309 | - | 24.8 | 46,334 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.77 per share. | 21 Oct 2021 | 859 | 346,137 | - | 24.8 | 21,277 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.82 per share. | 21 Oct 2021 | 1,165 | 344,972 | - | 24.8 | 28,913 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.82 per share. | 21 Oct 2021 | 6,604 | 1,388,179 | - | 24.8 | 163,900 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.77 per share. | 21 Oct 2021 | 4,864 | 1,394,783 | - | 24.8 | 120,480 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.73 per share. | 21 Oct 2021 | 15 | 346,996 | - | 24.7 | 371 | Common Stock |
| Morana Jovan-Embiricos | Director | Sale of securities on an exchange or to another person at price $ 24.75 per share. | 21 Oct 2021 | 85 | 1,399,647 | - | 24.8 | 2,104 | Common Stock |
| Ercem Atillasoy | See Remarks | Sale of securities on an exchange or to another person at price $ 24.23 per share. | 21 Oct 2021 | 1,514 | 104,986 | - | 24.2 | 36,690 | Common Stock |
| Agustin Melian | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 23.29 per share. | 04 Oct 2021 | 10,678 | 461,540 | - | 23.3 | 248,690 | Common Stock |
| Agustin Melian | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 26.02 per share. | 04 Oct 2021 | 333 | 453,529 | - | 26.0 | 8,666 | Common Stock |
| Agustin Melian | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 25.41 per share. | 04 Oct 2021 | 2,967 | 453,862 | - | 25.4 | 75,377 | Common Stock |
| Agustin Melian | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.23 per share. | 04 Oct 2021 | 4,711 | 456,829 | - | 24.2 | 114,129 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 25.04 per share. | 29 Sep 2021 | 1,000 | 434,179 | - | 25.0 | 25,037 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 25.07 per share. | 29 Sep 2021 | 3,413 | 418,595 | - | 25.1 | 85,575 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 25.17 per share. | 29 Sep 2021 | 12,171 | 422,008 | - | 25.2 | 306,294 | Common Stock |
| Agustin Melian | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.12 per share. | 28 Sep 2021 | 3,750 | 472,218 | - | 24.1 | 90,432 | Common Stock |
| David Hallal | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Jeffrey S. Bornstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| John Wilson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Juan Vera | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Malcolm Brenner | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 May 2021 | 818,663 | 0 | - | 0 | Common Stock | |
| Malcolm Brenner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Diana Brainard | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 500,000 | 500,000 | - | - | Stock Option (Right to Buy) | |
| Diana Brainard | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 170,000 | 206,300 | - | 0 | Common Stock | |
| Diana Brainard | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 30,000 | 36,300 | - | 0 | Common Stock | |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 22.75 per share. | 10 May 2021 | 150,000 | 2,309,142 | - | 22.8 | 3,412,500 | Common Stock |
| Agustin Melian | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.03 per share. | 05 Apr 2021 | 800 | 478,918 | - | 24.0 | 19,224 | Common Stock |
| Agustin Melian | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.01 per share. | 05 Apr 2021 | 2,950 | 475,968 | - | 24.0 | 70,842 | Common Stock |
| Agustin Melian | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 23.89 per share. | 05 Apr 2021 | 18,212 | 498,304 | - | 23.9 | 435,085 | Common Stock |
| Agustin Melian | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 19.99 per share. | 05 Apr 2021 | 18,586 | 479,718 | - | 20.0 | 371,534 | Common Stock |
| Agustin Melian | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 25.97 per share. | 22 Mar 2021 | 3,750 | 516,516 | - | 26.0 | 97,394 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 16 Mar 2021 | 3,025 | 2,459,142 | - | 30.0 | 90,751 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 30.87 per share. | 09 Mar 2021 | 3,397 | 3,165,723 | - | 30.9 | 104,876 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 30.87 per share. | 09 Mar 2021 | 10,188 | 5,415,261 | - | 30.9 | 314,535 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 32.31 per share. | 09 Mar 2021 | 300 | 3,169,120 | - | 32.3 | 9,694 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 32.31 per share. | 09 Mar 2021 | 900 | 5,425,449 | - | 32.3 | 29,081 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 31.60 per share. | 09 Mar 2021 | 8,418 | 3,169,420 | - | 31.6 | 265,974 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 31.59 per share. | 09 Mar 2021 | 25,256 | 5,426,349 | - | 31.6 | 797,921 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 30.93 per share. | 09 Mar 2021 | 9,467 | 3,177,838 | - | 30.9 | 292,807 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 30.93 per share. | 09 Mar 2021 | 28,402 | 5,451,605 | - | 30.9 | 878,449 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 31.70 per share. | 09 Mar 2021 | 10,169 | 3,187,306 | - | 31.7 | 322,318 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 31.70 per share. | 09 Mar 2021 | 30,506 | 5,480,008 | - | 31.7 | 966,921 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 31.30 per share. | 09 Mar 2021 | 52,440 | 5,510,514 | - | 31.3 | 1,641,157 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 31.30 per share. | 09 Mar 2021 | 17,480 | 3,197,475 | - | 31.3 | 547,052 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 31.63 per share. | 09 Mar 2021 | 769 | 3,164,954 | - | 31.6 | 24,322 | Common Stock |
| John Wilson | Director | Sale of securities on an exchange or to another person at price $ 31.63 per share. | 09 Mar 2021 | 2,308 | 5,412,953 | - | 31.6 | 72,997 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 35.46 per share. | 04 Mar 2021 | 13,876 | 886,515 | - | 35.5 | 492,025 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 34.40 per share. | 04 Mar 2021 | 701 | 818,663 | - | 34.4 | 24,117 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 33.31 per share. | 04 Mar 2021 | 2,300 | 819,364 | - | 33.3 | 76,604 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 32.19 per share. | 04 Mar 2021 | 6,141 | 821,664 | - | 32.2 | 197,670 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 31.27 per share. | 04 Mar 2021 | 15,289 | 827,805 | - | 31.3 | 478,075 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 30.39 per share. | 04 Mar 2021 | 23,660 | 843,094 | - | 30.4 | 719,034 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 37.41 per share. | 04 Mar 2021 | 10,947 | 866,754 | - | 37.4 | 409,555 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 36.58 per share. | 04 Mar 2021 | 8,814 | 877,701 | - | 36.6 | 322,405 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 34.67 per share. | 04 Mar 2021 | 15,961 | 900,391 | - | 34.7 | 553,314 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 39.14 per share. | 01 Mar 2021 | 2,200 | 192,811 | - | 39.1 | 86,108 | Common Stock |
| Edward Miller | General Counsel | Sale of securities on an exchange or to another person at price $ 38.58 per share. | 01 Mar 2021 | 3,800 | 195,011 | - | 38.6 | 146,592 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 39.21 per share. | 01 Mar 2021 | 1,600 | 488,230 | - | 39.2 | 62,733 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 38.62 per share. | 01 Mar 2021 | 4,332 | 489,830 | - | 38.6 | 167,301 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 37.28 per share. | 01 Mar 2021 | 4,190 | 2,366,720 | - | 37.3 | 156,189 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 38.28 per share. | 01 Mar 2021 | 11,570 | 2,392,194 | - | 38.3 | 442,842 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 38.73 per share. | 01 Mar 2021 | 20,584 | 2,371,610 | - | 38.7 | 797,266 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 39.53 per share. | 01 Mar 2021 | 700 | 2,370,910 | - | 39.5 | 27,671 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 38.30 per share. | 01 Mar 2021 | 9,001 | 2,357,719 | - | 38.3 | 344,708 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 39.10 per share. | 01 Mar 2021 | 1,803 | 2,355,916 | - | 39.1 | 70,500 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 37.01 per share. | 01 Mar 2021 | 1,300 | 2,354,616 | - | 37.0 | 48,114 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 38.22 per share. | 01 Mar 2021 | 7,142 | 2,347,474 | - | 38.2 | 272,954 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 38.63 per share. | 01 Mar 2021 | 7,546 | 2,339,928 | - | 38.6 | 291,518 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 39.18 per share. | 01 Mar 2021 | 3,159 | 2,462,167 | - | 39.2 | 123,758 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 38.46 per share. | 01 Mar 2021 | 6,359 | 2,465,326 | - | 38.5 | 244,572 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 37.35 per share. | 01 Mar 2021 | 3,727 | 943,198 | - | 37.3 | 139,199 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 38.27 per share. | 01 Mar 2021 | 7,317 | 935,881 | - | 38.3 | 280,016 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 39.14 per share. | 01 Mar 2021 | 1,614 | 934,267 | - | 39.1 | 63,173 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 36.91 per share. | 01 Mar 2021 | 3,383 | 930,884 | - | 36.9 | 124,861 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 37.73 per share. | 01 Mar 2021 | 6,032 | 924,852 | - | 37.7 | 227,617 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 38.53 per share. | 01 Mar 2021 | 8,500 | 916,352 | - | 38.5 | 327,472 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 38.39 per share. | 01 Mar 2021 | 12,825 | 955,794 | - | 38.4 | 492,327 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 39.00 per share. | 01 Mar 2021 | 8,869 | 946,925 | - | 39.0 | 345,900 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 43.14 per share. | 22 Feb 2021 | 800 | 64,765 | - | 43.1 | 34,509 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 42.82 per share. | 19 Feb 2021 | 2,200 | 496,280 | - | 42.8 | 94,201 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 41.53 per share. | 19 Feb 2021 | 600 | 498,480 | - | 41.5 | 24,917 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 41.71 per share. | 19 Feb 2021 | 4,165 | 499,080 | - | 41.7 | 173,720 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 40.32 per share. | 19 Feb 2021 | 700 | 494,162 | - | 40.3 | 28,227 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 39.18 per share. | 19 Feb 2021 | 1,418 | 494,862 | - | 39.2 | 55,556 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 40.97 per share. | 19 Feb 2021 | 600 | 2,403,764 | - | 41.0 | 24,582 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 39.11 per share. | 19 Feb 2021 | 4,825 | 2,406,664 | - | 39.1 | 188,692 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 38.33 per share. | 19 Feb 2021 | 1,125 | 2,411,489 | - | 38.3 | 43,116 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 43.40 per share. | 19 Feb 2021 | 380 | 2,412,614 | - | 43.4 | 16,493 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 41.79 per share. | 19 Feb 2021 | 13,233 | 2,426,935 | - | 41.8 | 553,011 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 41.58 per share. | 19 Feb 2021 | 2,891 | 2,424,044 | - | 41.6 | 120,215 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 42.80 per share. | 19 Feb 2021 | 11,050 | 2,412,994 | - | 42.8 | 472,907 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 40.13 per share. | 19 Feb 2021 | 2,300 | 2,404,364 | - | 40.1 | 92,294 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 39.59 per share. | 19 Feb 2021 | 1,907 | 2,472,485 | - | 39.6 | 75,498 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 40.56 per share. | 19 Feb 2021 | 800 | 2,471,685 | - | 40.6 | 32,448 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 38.83 per share. | 19 Feb 2021 | 1,492 | 2,474,392 | - | 38.8 | 57,931 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 42.84 per share. | 19 Feb 2021 | 4,506 | 2,475,884 | - | 42.8 | 193,034 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 41.54 per share. | 19 Feb 2021 | 1,200 | 2,480,390 | - | 41.5 | 49,846 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 41.75 per share. | 19 Feb 2021 | 7,541 | 2,481,590 | - | 41.8 | 314,868 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 42.80 per share. | 19 Feb 2021 | 8,779 | 977,418 | - | 42.8 | 375,746 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 41.78 per share. | 19 Feb 2021 | 11,990 | 988,531 | - | 41.8 | 500,935 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 41.58 per share. | 19 Feb 2021 | 2,334 | 986,197 | - | 41.6 | 97,054 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 41.19 per share. | 19 Feb 2021 | 200 | 968,619 | - | 41.2 | 8,238 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 40.40 per share. | 19 Feb 2021 | 1,801 | 968,819 | - | 40.4 | 72,769 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 39.46 per share. | 19 Feb 2021 | 3,688 | 970,620 | - | 39.5 | 145,529 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 38.75 per share. | 19 Feb 2021 | 2,800 | 974,308 | - | 38.7 | 108,499 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 43.37 per share. | 19 Feb 2021 | 310 | 977,108 | - | 43.4 | 13,446 | Common Stock |
| Jeffrey S. Bornstein | Director | Sale of securities on an exchange or to another person at price $ 40.39 per share. | 18 Feb 2021 | 19,771 | 812 | - | 40.4 | 798,606 | Common Stock |
| Jeffrey S. Bornstein | Director | Sale of securities on an exchange or to another person at price $ 41.27 per share. | 18 Feb 2021 | 812 | 0 | - | 41.3 | 33,513 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 39.36 per share. | 18 Feb 2021 | 200 | 66,106 | - | 39.4 | 7,871 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 40.39 per share. | 18 Feb 2021 | 541 | 65,565 | - | 40.4 | 21,853 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 39.84 per share. | 18 Feb 2021 | 535 | 504,795 | - | 39.8 | 21,312 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 41.50 per share. | 18 Feb 2021 | 750 | 503,245 | - | 41.5 | 31,126 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 40.44 per share. | 18 Feb 2021 | 800 | 503,995 | - | 40.4 | 32,349 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 40.44 per share. | 18 Feb 2021 | 4,032 | 2,443,878 | - | 40.4 | 163,069 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 41.49 per share. | 18 Feb 2021 | 3,710 | 2,440,168 | - | 41.5 | 153,923 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 39.48 per share. | 18 Feb 2021 | 1,200 | 2,447,910 | - | 39.5 | 47,376 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 40.44 per share. | 18 Feb 2021 | 1,100 | 2,490,431 | - | 40.4 | 44,484 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 41.50 per share. | 18 Feb 2021 | 1,300 | 2,489,131 | - | 41.5 | 53,950 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 39.20 per share. | 18 Feb 2021 | 300 | 2,491,531 | - | 39.2 | 11,760 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 40.34 per share. | 18 Feb 2021 | 2,800 | 1,003,503 | - | 40.3 | 112,950 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 41.49 per share. | 18 Feb 2021 | 2,982 | 1,000,521 | - | 41.5 | 123,732 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 39.68 per share. | 18 Feb 2021 | 975 | 1,006,303 | - | 39.7 | 38,684 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 17.82 per share. | 17 Feb 2021 | 15,205 | 441,608 | - | 17.8 | 270,953 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 39.65 per share. | 17 Feb 2021 | 15,196 | 490,134 | - | 39.6 | 602,521 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 37.93 per share. | 17 Feb 2021 | 512 | 472,522 | - | 37.9 | 19,420 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 22.80 per share. | 17 Feb 2021 | 15,201 | 457,321 | - | 22.8 | 346,583 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 22.87 per share. | 17 Feb 2021 | 508 | 456,813 | - | 22.9 | 11,618 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 19.86 per share. | 17 Feb 2021 | 513 | 441,095 | - | 19.9 | 10,188 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 25.08 per share. | 17 Feb 2021 | 5,916 | 435,179 | - | 25.1 | 148,362 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 38.56 per share. | 16 Feb 2021 | 600 | 68,026 | - | 38.6 | 23,138 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 42.67 per share. | 16 Feb 2021 | 300 | 68,626 | - | 42.7 | 12,802 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 41.82 per share. | 16 Feb 2021 | 2,750 | 68,926 | - | 41.8 | 115,014 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 41.68 per share. | 16 Feb 2021 | 200 | 66,306 | - | 41.7 | 8,336 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 41.17 per share. | 16 Feb 2021 | 1,300 | 66,506 | - | 41.2 | 53,520 | Common Stock |
| Brett R. Hagen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 39.86 per share. | 16 Feb 2021 | 220 | 67,806 | - | 39.9 | 8,769 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 39.72 per share. | 16 Feb 2021 | 400 | 506,730 | - | 39.7 | 15,887 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 42.52 per share. | 16 Feb 2021 | 400 | 507,630 | - | 42.5 | 17,009 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 41.76 per share. | 16 Feb 2021 | 2,700 | 508,030 | - | 41.8 | 112,761 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 41.56 per share. | 16 Feb 2021 | 100 | 505,330 | - | 41.6 | 4,156 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 41.22 per share. | 16 Feb 2021 | 1,300 | 505,430 | - | 41.2 | 53,582 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 38.42 per share. | 16 Feb 2021 | 500 | 507,130 | - | 38.4 | 19,212 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 42.53 per share. | 16 Feb 2021 | 966 | 2,456,570 | - | 42.5 | 41,081 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 41.79 per share. | 16 Feb 2021 | 9,434 | 2,457,536 | - | 41.8 | 394,284 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 16 Feb 2021 | 1,400 | 2,453,170 | - | 40.0 | 56,003 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 41.26 per share. | 16 Feb 2021 | 4,060 | 2,449,110 | - | 41.3 | 167,507 | Common Stock |
| Juan Vera | Director | Sale of securities on an exchange or to another person at price $ 38.71 per share. | 16 Feb 2021 | 2,000 | 2,454,570 | - | 38.7 | 77,421 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 38.63 per share. | 16 Feb 2021 | 500 | 2,493,617 | - | 38.6 | 19,313 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 42.79 per share. | 16 Feb 2021 | 200 | 2,494,117 | - | 42.8 | 8,558 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 41.82 per share. | 16 Feb 2021 | 2,850 | 2,494,317 | - | 41.8 | 119,175 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 41.28 per share. | 16 Feb 2021 | 1,386 | 2,491,831 | - | 41.3 | 57,215 | Common Stock |
| Ann Leen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 39.85 per share. | 16 Feb 2021 | 400 | 2,493,217 | - | 39.9 | 15,940 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 41.99 per share. | 16 Feb 2021 | 200 | 1,007,278 | - | 42.0 | 8,398 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 41.29 per share. | 16 Feb 2021 | 2,765 | 1,007,478 | - | 41.3 | 114,169 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 39.97 per share. | 16 Feb 2021 | 1,000 | 1,010,243 | - | 40.0 | 39,966 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 38.66 per share. | 16 Feb 2021 | 1,200 | 1,011,243 | - | 38.7 | 46,393 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 43.13 per share. | 16 Feb 2021 | 100 | 1,012,443 | - | 43.1 | 4,313 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 42.25 per share. | 16 Feb 2021 | 1,000 | 1,012,543 | - | 42.3 | 42,250 | Common Stock |
| Malcolm Brenner | Director | Sale of securities on an exchange or to another person at price $ 41.75 per share. | 16 Feb 2021 | 5,120 | 1,013,543 | - | 41.8 | 213,769 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 41.19 per share. | 02 Feb 2021 | 48,910 | 510,730 | - | 41.2 | 2,014,603 | Common Stock |
| Agustin Melian | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 41.19 per share. | 02 Feb 2021 | 54,849 | 520,266 | - | 41.2 | 2,259,230 | Common Stock |
| David Hallal | Director, Chief Executive Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2021 | 147,000 | 2,230,666 | - | 0 | Common Stock | |
| David Hallal | Director, Chief Executive Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2021 | 273,000 | 273,000 | - | - | Stock Option (Right to Buy) | |
| Vikas Sinha | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 58,800 | 865,407 | - | 0 | Common Stock | |
| Vikas Sinha | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 109,200 | 109,200 | - | - | Stock Option (Right to Buy) | |
| Edward Miller | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Jan 2021 | 41,514 | 166,051 | - | 0 | Common Stock | |
| Edward Miller | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 28,000 | 194,051 | - | 0 | Common Stock | |
| Edward Miller | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 52,000 | 52,000 | - | - | Stock Option (Right to Buy) | |
| Edward Miller | General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Jan 2021 | 41,514 | 198,811 | - | 0 | Common Stock | |
| Brett R. Hagen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 17,500 | 71,676 | - | 0 | Common Stock | |
| Brett R. Hagen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 32,500 | 32,500 | - | - | Stock Option (Right to Buy) | |
| Jeroen B. Van Beek | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 35,000 | 559,640 | - | 0 | Common Stock | |
| Jeroen B. Van Beek | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 65,000 | 65,000 | - | - | Stock Option (Right to Buy) | |
| Ann Leen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 28,000 | 28,000 | - | 0 | Common Stock | |
| Ann Leen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 52,000 | 52,000 | - | - | Stock Option (Right to Buy) | |
| Ann Leen | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Jan 2021 | 60,394 | 0 | - | 0 | Common Stock | |
| Ann Leen | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Jan 2021 | 60,394 | 60,394 | - | 0 | Common Stock | |
| Agustin Melian | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 81,250 | 81,250 | - | - | Stock Option (Right to Buy) | |
| Agustin Melian | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 43,750 | 575,115 | - | 0 | Common Stock | |
| Ercem Atillasoy | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 28,000 | 106,500 | - | 0 | Common Stock | |
| Ercem Atillasoy | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2021 | 52,000 | 52,000 | - | - | Stock Option (Right to Buy) | |
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | 03 Aug 2020 | 20,000,000 | 0 | - | - | Series A-2 Convertible Preferred Stock | ||
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | 03 Aug 2020 | 13,420,970 | 13,420,970 | - | - | Common Stock | ||
| David Hallal | Director, Chief Executive Officer, Ten Percent Owner | 03 Aug 2020 | 13,420,970 | 13,420,970 | - | - | Common Stock | ||
| David Hallal | Director, Chief Executive Officer, Ten Percent Owner | 03 Aug 2020 | 1,100,000 | 0 | - | - | Series A-4 Convertible Preferred Stock | ||
| David Hallal | Director, Chief Executive Officer, Ten Percent Owner | 03 Aug 2020 | 233,333 | 0 | - | - | Series A-4 Convertible Preferred Stock | ||
| David Hallal | Director, Chief Executive Officer, Ten Percent Owner | 03 Aug 2020 | 20,000,000 | 0 | - | - | Series A-2 Convertible Preferred Stock | ||
| David Hallal | Director, Chief Executive Officer, Ten Percent Owner | 03 Aug 2020 | 738,153 | 738,153 | - | - | Common Stock | ||
| David Hallal | Director, Chief Executive Officer, Ten Percent Owner | 03 Aug 2020 | 156,577 | 1,120,965 | - | - | Common Stock | ||
| Morana Jovan-Embiricos | Director, Ten Percent Owner | 03 Aug 2020 | 20,000,000 | 0 | - | - | Series A-2 Convertible Preferred Stock | ||
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 17.00 per share. | 03 Aug 2020 | 2,800,000 | 2,800,000 | - | 17 | 47,600,000 | Common Stock |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 17.00 per share. | 03 Aug 2020 | 100,000 | 347,011 | - | 17 | 1,700,000 | Common Stock |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | 03 Aug 2020 | 411,685 | 411,685 | - | - | Common Stock | ||
| Morana Jovan-Embiricos | Director, Ten Percent Owner | 03 Aug 2020 | 1,399,732 | 1,399,732 | - | - | Common Stock | ||
| Morana Jovan-Embiricos | Director, Ten Percent Owner | 03 Aug 2020 | 247,011 | 247,011 | - | - | Common Stock | ||
| Morana Jovan-Embiricos | Director, Ten Percent Owner | 03 Aug 2020 | 13,420,970 | 13,420,970 | - | - | Common Stock | ||
| Morana Jovan-Embiricos | Director, Ten Percent Owner | 03 Aug 2020 | 613,496 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Morana Jovan-Embiricos | Director, Ten Percent Owner | 03 Aug 2020 | 2,085,889 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Morana Jovan-Embiricos | Director, Ten Percent Owner | 03 Aug 2020 | 368,098 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Jeffrey S. Bornstein | Director | 03 Aug 2020 | 20,583 | 20,583 | - | - | Common Stock | ||
| Jeffrey S. Bornstein | Director | 03 Aug 2020 | 30,674 | 0 | - | - | Series B Preferred Convertible Stock | ||
| Edward Miller | General Counsel | 03 Aug 2020 | 48,819 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Edward Miller | General Counsel | 03 Aug 2020 | 32,759 | 32,759 | - | - | Common Stock | ||
| Brett R. Hagen | Chief Accounting Officer | 03 Aug 2020 | 6,500 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Brett R. Hagen | Chief Accounting Officer | 03 Aug 2020 | 4,361 | 54,176 | - | - | Common Stock | ||
| Jeroen B. Van Beek | Chief Commercial Officer | 03 Aug 2020 | 10,000 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Jeroen B. Van Beek | Chief Commercial Officer | Purchase of securities on an exchange or from another person at price $ 17.00 per share. | 03 Aug 2020 | 3,000 | 524,640 | - | 17 | 51,000 | Common Stock |
| Jeroen B. Van Beek | Chief Commercial Officer | 03 Aug 2020 | 6,710 | 521,640 | - | - | Common Stock | ||
| John Wilson | Director | 03 Aug 2020 | 4,745,943 | 0 | - | - | Series A-3 Convertible Preferred Stock | ||
| John Wilson | Director | 03 Aug 2020 | 3,499,001 | 0 | - | - | Series A-3 Convertible Preferred Stock | ||
| John Wilson | Director | 03 Aug 2020 | 2,347,999 | 5,562,954 | - | - | Common Stock | ||
| John Wilson | Director | 03 Aug 2020 | 3,184,758 | 3,214,955 | - | - | Common Stock | ||
| Juan Vera | Director | 03 Aug 2020 | 3,631,293 | 0 | - | - | Series A-3 Convertible Preferred Stock | ||
| Juan Vera | Director | 03 Aug 2020 | 2,436,773 | 2,466,970 | - | - | Common Stock | ||
| Ann Leen | Chief Scientific Officer | 03 Aug 2020 | 3,631,293 | 0 | - | - | Series A-3 Convertible Preferred Stock | ||
| Ann Leen | Chief Scientific Officer | 03 Aug 2020 | 2,436,773 | 2,436,773 | - | - | Common Stock | ||
| Ercem Atillasoy | See Remarks | Purchase of securities on an exchange or from another person at price $ 17.00 per share. | 03 Aug 2020 | 3,500 | 78,500 | - | 17 | 59,500 | Common Stock |
| Diana Brainard | Director | Purchase of securities on an exchange or from another person at price $ 17.00 per share. | 03 Aug 2020 | 6,300 | 6,300 | - | 17 | 107,100 | Common Stock |
| Malcolm Brenner | Director | 03 Aug 2020 | 1,018,663 | 1,018,663 | - | - | Common Stock | ||
| Malcolm Brenner | Director | 03 Aug 2020 | 1,518,018 | 0 | - | - | Series A-3 Convertible Preferred Stock | ||
| Vikas Sinha | Director, See Remarks, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 436,900 | 436,900 | - | - | Stock Option (Right to Buy) | |
| David Hallal | Director, Chief Executive Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 1,101,000 | 1,101,000 | - | - | Stock Option (Right to Buy) | |
| Morana Jovan-Embiricos | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Jeffrey S. Bornstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Edward Miller | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 200,600 | 200,600 | - | - | Stock Option (Right to Buy) | |
| Brett R. Hagen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 43,400 | 43,400 | - | - | Stock Option (Right to Buy) | |
| Jeroen B. Van Beek | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 237,200 | 237,200 | - | - | Stock Option (Right to Buy) | |
| John Wilson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Juan Vera | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) | |
| Ann Leen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 257,600 | 257,600 | - | - | Stock Option (Right to Buy) | |
| Agustin Melian | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 220,700 | 220,700 | - | - | Stock Option (Right to Buy) | |
| Ercem Atillasoy | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 75,000 | 75,000 | - | 0 | Common Stock | |
| Ercem Atillasoy | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 407,400 | 407,400 | - | - | Stock Option (Right to Buy) | |
| Diana Brainard | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 45,000 | 45,000 | - | - | Stock Option (Right to Buy) | |
| Malcolm Brenner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2020 | 22,500 | 22,500 | - | - | Stock Option (Right to Buy) |