758.1K XNAS Volume
XNAS 17 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Robert Iannone | EVP, Global Head of R&D & CMO | Sale of securities on an exchange or to another person at price $ 138.41 per share. | 10 Mar 2025 | 2,403 | 79,621 (0%) | 0% | 138.4 | 332,605 | Ordinary Shares |
| Mary E. Henderson | SVP, Technical Operations | Sale or transfer of securities back to the company at price $ 138.23 per share. | 07 Mar 2025 | 698 | 23,077 (0%) | 0% | 138.2 | 96,485 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale or transfer of securities back to the company at price $ 138.23 per share. | 07 Mar 2025 | 1,333 | 8,152 (0%) | 0% | 138.2 | 184,261 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 137.81 per share. | 07 Mar 2025 | 1,140 | 7,012 (0%) | 0% | 137.8 | 157,103 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale or transfer of securities back to the company at price $ 138.95 per share. | 05 Mar 2025 | 22,251 | 441,807 (0%) | 0% | 138.9 | 3,091,776 | Ordinary Shares |
| Renee D. Gala | President & COO | Sale or transfer of securities back to the company at price $ 138.95 per share. | 05 Mar 2025 | 5,704 | 88,895 (0%) | 0% | 139.0 | 792,571 | Ordinary Shares |
| Robert Iannone | EVP, Global Head of R&D & CMO | Sale of securities on an exchange or to another person at price $ 138.21 per share. | 05 Mar 2025 | 5,532 | 83,572 (0%) | 0% | 138.2 | 764,578 | Ordinary Shares |
| Robert Iannone | EVP, Global Head of R&D & CMO | Sale of securities on an exchange or to another person at price $ 140.00 per share. | 05 Mar 2025 | 1,548 | 82,024 (0%) | 0% | 140 | 216,720 | Ordinary Shares |
| Robert Iannone | EVP, Global Head of R&D & CMO | Sale or transfer of securities back to the company at price $ 138.95 per share. | 05 Mar 2025 | 5,239 | 89,104 (0%) | 0% | 138.9 | 727,959 | Ordinary Shares |
| Philip L. Johnson | EVP & Chief Financial Officer | Sale or transfer of securities back to the company at price $ 138.95 per share. | 05 Mar 2025 | 1,149 | 50,060 (0%) | 0% | 139.0 | 159,654 | Ordinary Shares |
| Neena M. Patil | EVP & Chief Legal Officer | Sale or transfer of securities back to the company at price $ 138.95 per share. | 05 Mar 2025 | 4,088 | 47,526 (0%) | 0% | 139.0 | 568,028 | Ordinary Shares |
| Samantha Pearce | EVP, Chief Commercial Officer | Sale or transfer of securities back to the company at price $ 138.95 per share. | 05 Mar 2025 | 1,905 | 41,226 (0%) | 0% | 139.0 | 264,700 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 30,814 | 470,558 (0%) | 0% | 0 | Ordinary Shares | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 144.25 per share. | 27 Feb 2025 | 6,500 | 464,058 (0%) | 0% | 144.3 | 937,625 | Ordinary Shares |
| Mary E. Henderson | SVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 3,852 | 23,775 (0%) | 0% | 0 | Ordinary Shares | |
| Mary E. Henderson | SVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 5,392 | 19,923 (0%) | 0% | 0 | Ordinary Shares | |
| Renee D. Gala | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 11,555 | 94,599 (0%) | 0% | 0 | Ordinary Shares | |
| Renee D. Gala | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 23,111 | 83,044 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Iannone | EVP, G R&D and CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 17,718 | 85,484 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Iannone | EVP, G R&D and CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 8,859 | 94,343 (0%) | 0% | 0 | Ordinary Shares | |
| Philip L. Johnson | EVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 7,704 | 51,209 (0%) | 0% | 0 | Ordinary Shares | |
| Philip L. Johnson | EVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 15,407 | 43,505 (0%) | 0% | 0 | Ordinary Shares | |
| Neena M. Patil | EVP & Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 12,518 | 45,836 (0%) | 0% | 0 | Ordinary Shares | |
| Neena M. Patil | EVP & Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 144.87 per share. | 27 Feb 2025 | 3,800 | 33,318 (0%) | 0% | 144.9 | 550,506 | Ordinary Shares |
| Neena M. Patil | EVP & Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 5,778 | 51,614 (0%) | 0% | 0 | Ordinary Shares | |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 144.42 per share. | 27 Feb 2025 | 313 | 8,237 (0%) | 0% | 144.4 | 45,202 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale or transfer of securities back to the company at price $ 142.43 per share. | 27 Feb 2025 | 497 | 7,369 (0%) | 0% | 142.4 | 70,788 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 144.42 per share. | 27 Feb 2025 | 4,500 | 8,237 (0%) | 0% | 144.4 | 649,873 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 123.36 per share. | 27 Feb 2025 | 313 | 8,550 (0%) | 0% | 123.4 | 38,612 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale or transfer of securities back to the company at price $ 142.43 per share. | 27 Feb 2025 | 371 | 7,866 (0%) | 0% | 142.4 | 52,840 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 313 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patricia Carr | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 4,500 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 143.29 per share. | 27 Feb 2025 | 773 | 9,485 (0%) | 0% | 143.3 | 110,767 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 2,889 | 10,258 (0%) | 0% | 0 | Ordinary Shares | |
| Patricia Carr | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 113.10 per share. | 27 Feb 2025 | 4,500 | 12,737 (0%) | 0% | 113.1 | 508,950 | Ordinary Shares |
| Samantha Pearce | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 11,941 | 37,353 (0%) | 0% | 0 | Ordinary Shares | |
| Samantha Pearce | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 5,778 | 43,131 (0%) | 0% | 0 | Ordinary Shares | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 122.31 per share. | 03 Feb 2025 | 1,500 | 439,744 (0%) | 0% | 122.3 | 183,465 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 122.62 per share. | 17 Jan 2025 | 13,840 | 441,244 (0%) | 0% | 122.6 | 1,697,061 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 29,559 | 455,084 (0%) | 0% | 0 | Ordinary Shares | |
| Renee D. Gala | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 7,741 | 63,233 (0%) | 0% | 0 | Ordinary Shares | |
| Renee D. Gala | President & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 122.62 per share. | 17 Jan 2025 | 3,300 | 59,933 (0%) | 0% | 122.6 | 404,646 | Ordinary Shares |
| Robert Iannone | EVP, G R&D and CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 122.62 per share. | 17 Jan 2025 | 2,181 | 67,766 (0%) | 0% | 122.6 | 267,434 | Ordinary Shares |
| Robert Iannone | EVP, G R&D and CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 7,506 | 69,947 (0%) | 0% | 0 | Ordinary Shares | |
| Neena M. Patil | EVP & Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 122.62 per share. | 17 Jan 2025 | 1,905 | 37,118 (0%) | 0% | 122.6 | 233,591 | Ordinary Shares |
| Neena M. Patil | EVP & Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 5,864 | 39,023 (0%) | 0% | 0 | Ordinary Shares | |
| Patricia Carr | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 1,641 | 8,237 (0%) | 0% | 0 | Ordinary Shares | |
| Samantha Pearce | EVP, Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 122.62 per share. | 17 Jan 2025 | 1,365 | 25,412 (0%) | 0% | 122.6 | 167,376 | Ordinary Shares |
| Samantha Pearce | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2025 | 2,533 | 26,777 (0%) | 0% | 0 | Ordinary Shares | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 123.43 per share. | 02 Jan 2025 | 1,500 | 425,525 (0%) | 0% | 123.4 | 185,145 | Ordinary Shares |
| Renee D. Gala | President & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 123.45 per share. | 05 Dec 2024 | 80 | 55,492 (0%) | 0% | 123.5 | 9,876 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 121.17 per share. | 02 Dec 2024 | 2,000 | 427,025 (0%) | 0% | 121.2 | 242,340 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 122.49 per share. | 02 Dec 2024 | 53 | 6,596 (0%) | 0% | 122.5 | 6,492 | Ordinary Shares |
| Neena M. Patil | EVP & Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 123.41 per share. | 08 Nov 2024 | 3,700 | 33,048 (0%) | 0% | 123.4 | 456,617 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 110.84 per share. | 01 Nov 2024 | 1,000 | 428,976 (0%) | 0% | 110.8 | 110,840 | Ordinary Shares |
| Mary E. Henderson | SVP, Technical Operations | Sale of securities on an exchange or to another person at price $ 108.30 per share. | 06 Sep 2024 | 1,410 | 14,531 (0%) | 0% | 108.3 | 152,703 | Ordinary Shares |
| Patrick G. Enright | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2024 | 3,731 | 24,677 (0%) | 0% | 0 | Ordinary Shares | |
| Norbert G. Riedel | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 111.35 per share. | 02 Aug 2024 | 1,484 | 5,322 (0%) | 0% | 111.3 | 165,243 | Ordinary Shares |
| Norbert G. Riedel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2024 | 3,731 | 6,806 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2024 | 3,731 | 14,175 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 111.35 per share. | 02 Aug 2024 | 1,484 | 12,691 (0%) | 0% | 111.3 | 165,243 | Ordinary Shares |
| Heather Ann McSharry | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 111.35 per share. | 02 Aug 2024 | 1,608 | 18,901 (0%) | 0% | 111.4 | 179,051 | Ordinary Shares |
| Heather Ann McSharry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2024 | 3,731 | 20,509 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth W. O'Keefe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2024 | 3,731 | 28,454 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth W. O'Keefe | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 111.35 per share. | 02 Aug 2024 | 1,484 | 26,970 (0%) | 0% | 111.3 | 165,243 | Ordinary Shares |
| Patrick Thomas Kennedy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2024 | 3,731 | 5,154 (0%) | 0% | 0 | Ordinary Shares | |
| Seamus C. Mulligan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2024 | 3,731 | 1,176,106 (2%) | 0% | 0 | Ordinary Shares | |
| Laura J. Hamill | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2024 | 3,731 | 5,231 (0%) | 0% | 0 | Ordinary Shares | |
| Jennifer E. Cook | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 111.35 per share. | 02 Aug 2024 | 1,484 | 9,135 (0%) | 0% | 111.3 | 165,243 | Ordinary Shares |
| Jennifer E. Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2024 | 3,731 | 10,619 (0%) | 0% | 0 | Ordinary Shares | |
| Anne O'Riordan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2024 | 3,731 | 16,282 (0%) | 0% | 0 | Ordinary Shares | |
| Anne O'Riordan | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 111.35 per share. | 02 Aug 2024 | 1,484 | 14,798 (0%) | 0% | 111.3 | 165,243 | Ordinary Shares |
| Samantha Pearce | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2024 | 6,996 | 24,078 (0%) | 0% | 0 | Ordinary Shares | |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 108.82 per share. | 07 Jun 2024 | 163 | 6,596 (0%) | 0% | 108.8 | 17,738 | Ordinary Shares |
| Neena M. Patil | EVP & Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 109.65 per share. | 03 May 2024 | 5,000 | 36,629 (0%) | 0% | 109.7 | 548,250 | Ordinary Shares |
| Renee D. Gala | President & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 115.21 per share. | 05 Apr 2024 | 1,736 | 55,357 (0%) | 0% | 115.2 | 200,005 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 116.98 per share. | 06 Mar 2024 | 1,768 | 6,596 (0%) | 0% | 117.0 | 206,821 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 117.51 per share. | 06 Mar 2024 | 700 | 8,364 (0%) | 0% | 117.5 | 82,257 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 120.85 per share. | 06 Mar 2024 | 1,236 | 9,064 (0%) | 0% | 120.9 | 149,371 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.53 per share. | 05 Mar 2024 | 22,436 | 429,809 (0%) | 0% | 117.5 | 2,636,903 | Ordinary Shares |
| Renee D. Gala | President & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.53 per share. | 05 Mar 2024 | 3,622 | 57,093 (0%) | 0% | 117.5 | 425,694 | Ordinary Shares |
| Robert Iannone | EVP, Global Head of R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.53 per share. | 05 Mar 2024 | 4,294 | 62,226 (0%) | 0% | 117.5 | 504,674 | Ordinary Shares |
| Neena M. Patil | EVP & Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.53 per share. | 05 Mar 2024 | 3,432 | 41,629 (0%) | 0% | 117.5 | 403,363 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.53 per share. | 05 Mar 2024 | 2,474 | 16,922 (0%) | 0% | 117.5 | 290,769 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 50,187 | 452,245 (0%) | 0% | 0 | Ordinary Shares | |
| Mary E. Henderson | SVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 5,178 | 15,941 (0%) | 0% | 0 | Ordinary Shares | |
| Patrick Thomas Kennedy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 1,423 | 1,423 (0%) | 0% | 0 | Common Stock | |
| Renee D. Gala | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 19,916 | 60,715 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Iannone | EVP, Global Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 16,928 | 66,520 (0%) | 0% | 0 | Ordinary Shares | |
| Philip L. Johnson | EVP & Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 119.65 per share. | 01 Mar 2024 | 12,000 | 27,932 (0%) | 0% | 119.7 | 1,435,800 | Ordinary Shares |
| Philip L. Johnson | EVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 15,932 | 15,932 (0%) | 0% | 0 | Ordinary Shares | |
| Neena M. Patil | EVP & Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 12,348 | 45,061 (0%) | 0% | 0 | Ordinary Shares | |
| Patricia Carr | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 2,987 | 10,300 (0%) | 0% | 0 | Ordinary Shares | |
| Samantha Pearce | SVP, Head of Europe & Internat | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 5,065 | 19,396 (0%) | 0% | 0 | Ordinary Shares | |
| Pearce Samantha | SVP, Head of Europe & Internat | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2024 | 2,210 | 15,369 (0%) | 0% | 0 | Ordinary Shares | |
| Pearce Samantha | SVP, Head of Europe & Internat | Payment of exercise price or tax liability using portion of securities received from the company at price $ 119.13 per share. | 17 Jan 2024 | 1,038 | 14,331 (0%) | 0% | 119.1 | 123,657 | Ordinary Shares |
| Gala Renee D. | President & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 119.13 per share. | 17 Jan 2024 | 3,204 | 40,799 (0%) | 0% | 119.1 | 381,693 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2024 | 1,327 | 7,363 (0%) | 0% | 0 | Ordinary Shares | |
| Iannone Robert | EVP, Global Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2024 | 5,970 | 51,322 (0%) | 0% | 0 | Ordinary Shares | |
| Iannone Robert | EVP, Global Head of R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 119.13 per share. | 17 Jan 2024 | 1,730 | 49,592 (0%) | 0% | 119.1 | 206,095 | Ordinary Shares |
| Cozadd Bruce C. | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2024 | 26,545 | 414,303 (0%) | 0% | 0 | Ordinary Shares | |
| Renee Gala D. | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2024 | 7,079 | 44,003 (0%) | 0% | 0 | Ordinary Shares | |
| Neena Patil M. | EVP & Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2024 | 5,087 | 34,369 (0%) | 0% | 0 | Ordinary Shares | |
| Cozadd Bruce C. | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 119.13 per share. | 17 Jan 2024 | 12,245 | 402,058 (0%) | 0% | 119.1 | 1,458,747 | Ordinary Shares |
| Patil Neena M. | EVP & Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 119.13 per share. | 17 Jan 2024 | 1,656 | 32,713 (0%) | 0% | 119.1 | 197,279 | Ordinary Shares |
| Carr Patricia | SVP, Chief Accounting Officer | 31 Dec 2023 | 50 | 5,986 (0%) | 0% | 121.4 | 6,070 | Ordinary Shares | |
| Cook Jennifer E. | Director | Sale of securities on an exchange or to another person at price $ 119.27 per share. | 04 Dec 2023 | 417 | 6,888 (0%) | 0% | 119.3 | 49,736 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 143.47 per share. | 29 Aug 2023 | 142 | 5,986 (0%) | 0% | 143.5 | 20,373 | Ordinary Shares |
| Neena M. Patil | EVP & Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 139.59 per share. | 15 Aug 2023 | 750 | 30,686 (0%) | 0% | 139.6 | 104,695 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 138.16 per share. | 14 Aug 2023 | 158 | 6,128 (0%) | 0% | 138.2 | 21,829 | Ordinary Shares |
| Patrick G. Enright | Director | Sale of securities on an exchange or to another person at price $ 138.16 per share. | 11 Aug 2023 | 1,241 | 20,946 (0%) | 0% | 138.2 | 171,455 | Ordinary Shares |
| Patrick G. Enright | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Aug 2023 | 3,075 | 22,187 (0%) | 0% | 0 | Ordinary Shares | |
| Norbert G. Riedel | Director | Sale of securities on an exchange or to another person at price $ 138.16 per share. | 11 Aug 2023 | 1,241 | 13,705 (0%) | 0% | 138.2 | 171,454 | Ordinary Shares |
| Norbert G. Riedel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Aug 2023 | 3,075 | 14,946 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director | Sale of securities on an exchange or to another person at price $ 138.16 per share. | 11 Aug 2023 | 1,241 | 10,444 (0%) | 0% | 138.2 | 171,455 | Ordinary Shares |
| Rick E. Winningham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Aug 2023 | 3,075 | 11,685 (0%) | 0% | 0 | Ordinary Shares | |
| Mary E. Henderson | SVP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Aug 2023 | 10,763 | 10,763 (0%) | 0% | 0 | Ordinary Shares | |
| Heather Ann McSharry | Director | Sale of securities on an exchange or to another person at price $ 138.16 per share. | 11 Aug 2023 | 1,344 | 16,778 (0%) | 0% | 138.2 | 185,685 | Ordinary Shares |
| Heather Ann McSharry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Aug 2023 | 3,075 | 18,122 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth W. O'Keefe | Director | Sale of securities on an exchange or to another person at price $ 138.16 per share. | 11 Aug 2023 | 1,241 | 24,723 (0%) | 0% | 138.2 | 171,455 | Ordinary Shares |
| Kenneth W. O'Keefe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Aug 2023 | 3,075 | 25,964 (0%) | 0% | 0 | Ordinary Shares | |
| Peter P. Gray | Director | Sale of securities on an exchange or to another person at price $ 138.16 per share. | 11 Aug 2023 | 1,241 | 16,068 (0%) | 0% | 138.2 | 171,455 | Ordinary Shares |
| Peter P. Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Aug 2023 | 3,075 | 17,309 (0%) | 0% | 0 | Ordinary Shares | |
| Seamus C. Mulligan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Aug 2023 | 3,075 | 1,172,375 (2%) | 0% | 0 | Ordinary Shares | |
| Catherine Angell Sohn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Aug 2023 | 3,075 | 16,109 (0%) | 0% | 0 | Ordinary Shares | |
| Catherine Angell Sohn | Director | Sale of securities on an exchange or to another person at price $ 138.16 per share. | 11 Aug 2023 | 1,241 | 14,868 (0%) | 0% | 138.2 | 171,455 | Ordinary Shares |
| Jennifer E. Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Aug 2023 | 3,075 | 8,546 (0%) | 0% | 0 | Ordinary Shares | |
| Jennifer E. Cook | Director | Sale of securities on an exchange or to another person at price $ 138.16 per share. | 11 Aug 2023 | 1,241 | 7,305 (0%) | 0% | 138.2 | 171,454 | Ordinary Shares |
| Anne O'Riordan | Director | Sale of securities on an exchange or to another person at price $ 138.16 per share. | 11 Aug 2023 | 1,241 | 12,551 (0%) | 0% | 138.2 | 171,454 | Ordinary Shares |
| Anne O'Riordan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Aug 2023 | 3,075 | 13,792 (0%) | 0% | 0 | Ordinary Shares | |
| Neena M. Patil | EVP & Chief Legal Officer | Sale or transfer of securities back to the company at price $ 131.51 per share. | 07 Aug 2023 | 1,390 | 31,436 (0%) | 0% | 131.5 | 182,799 | Ordinary Shares |
| Seamus C. Mulligan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.76 per share. | 08 Jun 2023 | 4,500 | 1,169,300 (2%) | 0% | 81.8 | 367,920 | Ordinary Shares |
| Seamus C. Mulligan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jun 2023 | 4,500 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 127.91 per share. | 07 Jun 2023 | 126 | 6,286 (0%) | 0% | 127.9 | 16,117 | Ordinary Shares |
| Robert Iannone | EVP, Global Head of Research a | Sale or transfer of securities back to the company at price $ 129.73 per share. | 05 Jun 2023 | 1,311 | 45,315 (0%) | 0% | 129.7 | 170,076 | Ordinary Shares |
| Kim Sablich | EVP, GM of U.S. | Sale or transfer of securities back to the company at price $ 129.73 per share. | 05 Jun 2023 | 2,082 | 28,478 (0%) | 0% | 129.7 | 270,098 | Ordinary Shares |
| Neena M. Patil | EVP & Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 128.01 per share. | 01 Jun 2023 | 74 | 32,826 (0%) | 0% | 128.0 | 9,473 | Ordinary Shares |
| Neena M. Patil | EVP & Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 127.98 per share. | 01 Jun 2023 | 1,526 | 32,900 (0%) | 0% | 128.0 | 195,290 | Ordinary Shares |
| Renee D. Gala | EVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 131.75 per share. | 18 May 2023 | 6,000 | 35,978 (0%) | 0% | 131.7 | 790,474 | Ordinary Shares |
| Renee D. Gala | EVP & Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 145.78 per share. | 05 Apr 2023 | 1,807 | 41,978 (0%) | 0% | 145.8 | 263,424 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 133.22 per share. | 15 Mar 2023 | 1,023 | 6,286 (0%) | 0% | 133.2 | 136,284 | Ordinary Shares |
| Kim Sablich | EVP, GM of U.S., Commercial Ma | Sale of securities on an exchange or to another person at price $ 140.19 per share. | 08 Mar 2023 | 1,261 | 30,560 (0%) | 0% | 140.2 | 176,780 | Ordinary Shares |
| Kim Sablich | EVP, GM of U.S., Commercial Ma | Sale of securities on an exchange or to another person at price $ 139.42 per share. | 08 Mar 2023 | 1,752 | 31,821 (0%) | 0% | 139.4 | 244,264 | Ordinary Shares |
| Kenneth W. O'Keefe | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.76 per share. | 07 Mar 2023 | 4,500 | 25,579 (0%) | 0% | 81.8 | 367,920 | Ordinary Shares |
| Kenneth W. O'Keefe | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2023 | 4,500 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Kenneth W. O'Keefe | Director | Sale of securities on an exchange or to another person at price $ 138.39 per share. | 07 Mar 2023 | 2,690 | 22,889 (0%) | 0% | 138.4 | 372,267 | Ordinary Shares |
| Seamus C. Mulligan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.13 per share. | 04 Mar 2023 | 4,500 | 1,164,800 (2%) | 0% | 59.1 | 266,085 | Ordinary Shares |
| Seamus C. Mulligan | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2023 | 4,500 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2023 | 42,388 | 409,466 (0%) | 0% | 0 | Ordinary Shares | |
| Bruce C. Cozadd | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.78 per share. | 03 Mar 2023 | 21,882 | 387,584 (0%) | 0% | 142.8 | 3,124,312 | Ordinary Shares |
| Daniel N. Swisher | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.78 per share. | 03 Mar 2023 | 5,426 | 55,014 (0%) | 0% | 142.8 | 774,724 | Ordinary Shares |
| Daniel N. Swisher | President and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2023 | 13,456 | 60,440 (0%) | 0% | 0 | Ordinary Shares | |
| Renee D. Gala | EVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2023 | 12,784 | 45,342 (0%) | 0% | 0 | Ordinary Shares | |
| Renee D. Gala | EVP & Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.78 per share. | 03 Mar 2023 | 1,557 | 43,785 (0%) | 0% | 142.8 | 222,308 | Ordinary Shares |
| Robert Iannone | EVP, Global Head of Research a | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.78 per share. | 03 Mar 2023 | 2,274 | 46,489 (0%) | 0% | 142.8 | 324,682 | Ordinary Shares |
| Robert Iannone | EVP, Global Head of Research a | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2023 | 12,447 | 48,763 (0%) | 0% | 0 | Ordinary Shares | |
| Kim Sablich | EVP, GM of U.S., Commercial Ma | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.78 per share. | 03 Mar 2023 | 1,610 | 33,573 (0%) | 0% | 142.8 | 229,876 | Ordinary Shares |
| Kim Sablich | EVP, GM of U.S., Commercial Ma | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2023 | 10,429 | 35,183 (0%) | 0% | 0 | Ordinary Shares | |
| Neena M. Patil | EVP & Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.78 per share. | 03 Mar 2023 | 1,923 | 34,339 (0%) | 0% | 142.8 | 274,566 | Ordinary Shares |
| Neena M. Patil | EVP & Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2023 | 9,419 | 36,262 (0%) | 0% | 0 | Ordinary Shares | |
| Patricia Carr | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2023 | 2,523 | 8,457 (0%) | 0% | 0 | Ordinary Shares | |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 140.76 per share. | 03 Mar 2023 | 1,148 | 7,309 (0%) | 0% | 140.8 | 161,594 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2023 | 3,870 | 15,179 (0%) | 0% | 0 | Ordinary Shares | |
| Samantha Pearce | SVP, Head of Europe & Internat | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.78 per share. | 03 Mar 2023 | 2,020 | 13,159 (0%) | 0% | 142.8 | 288,416 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Sale of securities on an exchange or to another person at price $ 157.26 per share. | 02 Feb 2023 | 531 | 11,309 (0%) | 0% | 157.3 | 83,505 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2023 | 531 | 6,907 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 109.45 per share. | 02 Feb 2023 | 531 | 11,840 (0%) | 0% | 109.5 | 58,118 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 155.79 per share. | 01 Feb 2023 | 1,000 | 367,078 (0%) | 0% | 155.8 | 155,790 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 159.59 per share. | 03 Jan 2023 | 1,000 | 370,078 (0%) | 0% | 159.6 | 159,590 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 160.00 per share. | 03 Jan 2023 | 2,000 | 368,078 (0%) | 0% | 160 | 320,000 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2023 | 531 | 7,438 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Head of Europe & Internat | Sale of securities on an exchange or to another person at price $ 159.59 per share. | 03 Jan 2023 | 531 | 11,309 (0%) | 0% | 159.6 | 84,742 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 109.45 per share. | 03 Jan 2023 | 531 | 11,840 (0%) | 0% | 109.5 | 58,118 | Ordinary Shares |
| Renee D. Gala | EVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 160.00 per share. | 21 Dec 2022 | 2,635 | 32,558 (0%) | 0% | 160 | 421,600 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2022 | 531 | 7,969 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Head of Europe & Internat | Sale of securities on an exchange or to another person at price $ 155.45 per share. | 13 Dec 2022 | 531 | 11,309 (0%) | 0% | 155.5 | 82,544 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 109.45 per share. | 13 Dec 2022 | 531 | 11,840 (0%) | 0% | 109.5 | 58,118 | Ordinary Shares |
| Robert Iannone | EVP, Global Head of R&D | Sale of securities on an exchange or to another person at price $ 151.54 per share. | 09 Dec 2022 | 1,844 | 36,316 (0%) | 0% | 151.5 | 279,440 | Ordinary Shares |
| Daniel N. Swisher | President and COO | Other type of transaction at price $ 0.00 per share. | 05 Dec 2022 | 10,465 | 46,984 (0%) | 0% | 0 | Ordinary Shares | |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 152.06 per share. | 05 Dec 2022 | 63 | 5,934 (0%) | 0% | 152.1 | 9,580 | Ordinary Shares |
| Jennifer Cook | Director | Sale of securities on an exchange or to another person at price $ 154.68 per share. | 02 Dec 2022 | 420 | 5,471 (0%) | 0% | 154.7 | 64,966 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 157.00 per share. | 01 Dec 2022 | 1,000 | 371,078 (0%) | 0% | 157 | 157,000 | Ordinary Shares |
| Neena M. Patil | EVP & Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 142.34 per share. | 16 Nov 2022 | 3,510 | 26,769 (0%) | 0% | 142.3 | 499,613 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 150.00 per share. | 10 Nov 2022 | 2,000 | 372,028 (0%) | 0% | 150 | 300,000 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Nov 2022 | 531 | 8,500 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Nov 2022 | 532 | 9,031 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Head of Europe & Internat | Sale of securities on an exchange or to another person at price $ 155.00 per share. | 10 Nov 2022 | 531 | 11,309 (0%) | 0% | 155 | 82,305 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 109.45 per share. | 10 Nov 2022 | 531 | 11,840 (0%) | 0% | 109.5 | 58,118 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Sale of securities on an exchange or to another person at price $ 155.00 per share. | 10 Nov 2022 | 532 | 11,309 (0%) | 0% | 155 | 82,460 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 109.45 per share. | 10 Nov 2022 | 532 | 11,841 (0%) | 0% | 109.4 | 58,227 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 134.02 per share. | 03 Oct 2022 | 13,791 | 405,422 (0%) | 0% | 134.0 | 1,848,307 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Oct 2022 | 62,905 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 135.80 per share. | 03 Oct 2022 | 7,748 | 374,028 (0%) | 0% | 135.8 | 1,052,213 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 135.18 per share. | 03 Oct 2022 | 23,646 | 381,776 (0%) | 0% | 135.2 | 3,196,386 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.13 per share. | 03 Oct 2022 | 62,905 | 419,213 (0%) | 0% | 59.1 | 3,719,573 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 155.10 per share. | 06 Sep 2022 | 1,000 | 353,311 (0%) | 0% | 155.1 | 155,100 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Sep 2022 | 9,700 | 62,905 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 155.22 per share. | 06 Sep 2022 | 542 | 356,308 (0%) | 0% | 155.2 | 84,129 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 154.31 per share. | 06 Sep 2022 | 474 | 356,850 (0%) | 0% | 154.3 | 73,143 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 153.13 per share. | 06 Sep 2022 | 1,170 | 357,324 (0%) | 0% | 153.1 | 179,162 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 152.41 per share. | 06 Sep 2022 | 4,517 | 358,494 (0%) | 0% | 152.4 | 688,436 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.13 per share. | 06 Sep 2022 | 9,700 | 363,011 (0%) | 0% | 59.1 | 573,561 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Sale of securities on an exchange or to another person at price $ 156.98 per share. | 02 Sep 2022 | 531 | 11,309 (0%) | 0% | 157.0 | 83,356 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Sep 2022 | 531 | 9,563 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 109.45 per share. | 02 Sep 2022 | 531 | 11,840 (0%) | 0% | 109.5 | 58,118 | Ordinary Shares |
| Peter P. Gray | Director | Sale of securities on an exchange or to another person at price $ 158.00 per share. | 18 Aug 2022 | 8,000 | 14,234 (0%) | 0% | 158 | 1,264,000 | Ordinary Shares |
| Peter P. Gray | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Aug 2022 | 8,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Peter P. Gray | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 55.28 per share. | 18 Aug 2022 | 8,000 | 22,234 (0%) | 0% | 55.3 | 442,240 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 113.10 per share. | 15 Aug 2022 | 2,000 | 7,934 (0%) | 0% | 113.1 | 226,200 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Aug 2022 | 2,000 | 4,500 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 160.29 per share. | 15 Aug 2022 | 2,000 | 5,934 (0%) | 0% | 160.3 | 320,580 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 156.86 per share. | 15 Aug 2022 | 142 | 5,934 (0%) | 0% | 156.9 | 22,274 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 152.32 per share. | 08 Aug 2022 | 158 | 6,076 (0%) | 0% | 152.3 | 24,067 | Ordinary Shares |
| Patrick G. Enright | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2022 | 2,561 | 25,175 (0%) | 0% | 0 | Ordinary Shares | |
| Patrick G. Enright | Director | Sale of securities on an exchange or to another person at price $ 152.33 per share. | 05 Aug 2022 | 1,089 | 24,086 (0%) | 0% | 152.3 | 165,883 | Ordinary Shares |
| Norbert G. Riedel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2022 | 8,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Norbert G. Riedel | Director | Sale of securities on an exchange or to another person at price $ 152.32 per share. | 05 Aug 2022 | 1,089 | 11,871 (0%) | 0% | 152.3 | 165,877 | Ordinary Shares |
| Norbert G. Riedel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2022 | 2,561 | 12,960 (0%) | 0% | 0 | Ordinary Shares | |
| Norbert G. Riedel | Director | Sale of securities on an exchange or to another person at price $ 155.86 per share. | 05 Aug 2022 | 8,000 | 10,399 (0%) | 0% | 155.9 | 1,246,920 | Ordinary Shares |
| Norbert G. Riedel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 55.28 per share. | 05 Aug 2022 | 8,000 | 18,399 (0%) | 0% | 55.3 | 442,240 | Ordinary Shares |
| Rick E. Winningham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2022 | 2,561 | 9,699 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director | Sale of securities on an exchange or to another person at price $ 152.32 per share. | 05 Aug 2022 | 1,089 | 8,610 (0%) | 0% | 152.3 | 165,879 | Ordinary Shares |
| Heather Ann McSharry | Director | Sale of securities on an exchange or to another person at price $ 154.59 per share. | 05 Aug 2022 | 5,500 | 15,047 (0%) | 0% | 154.6 | 850,268 | Ordinary Shares |
| Heather Ann McSharry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2022 | 8,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Heather Ann McSharry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 55.28 per share. | 05 Aug 2022 | 8,000 | 20,547 (0%) | 0% | 55.3 | 442,240 | Ordinary Shares |
| Heather Ann McSharry | Director | Sale of securities on an exchange or to another person at price $ 152.32 per share. | 05 Aug 2022 | 1,179 | 12,547 (0%) | 0% | 152.3 | 179,590 | Ordinary Shares |
| Heather Ann McSharry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2022 | 2,561 | 13,726 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth W. O'Keefe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2022 | 2,561 | 22,168 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth W. O'Keefe | Director | Sale of securities on an exchange or to another person at price $ 152.33 per share. | 05 Aug 2022 | 1,089 | 21,079 (0%) | 0% | 152.3 | 165,883 | Ordinary Shares |
| Peter P. Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2022 | 2,561 | 15,413 (0%) | 0% | 0 | Ordinary Shares | |
| Peter P. Gray | Director | Sale of securities on an exchange or to another person at price $ 152.32 per share. | 05 Aug 2022 | 1,179 | 14,234 (0%) | 0% | 152.3 | 179,588 | Ordinary Shares |
| Seamus C. Mulligan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2022 | 2,561 | 1,160,300 (2%) | 0% | 0 | Ordinary Shares | |
| Catherine A. Sohn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2022 | 2,561 | 14,123 (0%) | 0% | 0 | Ordinary Shares | |
| Catherine A. Sohn | Director | Sale of securities on an exchange or to another person at price $ 152.32 per share. | 05 Aug 2022 | 1,089 | 13,034 (0%) | 0% | 152.3 | 165,880 | Ordinary Shares |
| Jennifer Cook | Director | Sale of securities on an exchange or to another person at price $ 152.32 per share. | 05 Aug 2022 | 1,089 | 5,891 (0%) | 0% | 152.3 | 165,879 | Ordinary Shares |
| Jennifer Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2022 | 2,561 | 6,980 (0%) | 0% | 0 | Ordinary Shares | |
| Anne O'Riordan | Director | Sale of securities on an exchange or to another person at price $ 152.32 per share. | 05 Aug 2022 | 1,089 | 10,717 (0%) | 0% | 152.3 | 165,877 | Ordinary Shares |
| Anne O'Riordan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Aug 2022 | 2,561 | 11,806 (0%) | 0% | 0 | Ordinary Shares | |
| Neena M. Patil | EVP and Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.72 per share. | 05 Aug 2022 | 1,321 | 30,279 (0%) | 0% | 153.7 | 203,064 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Sale of securities on an exchange or to another person at price $ 155.00 per share. | 04 Aug 2022 | 531 | 11,309 (0%) | 0% | 155 | 82,305 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Aug 2022 | 531 | 10,094 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 109.45 per share. | 04 Aug 2022 | 531 | 11,840 (0%) | 0% | 109.5 | 58,118 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.13 per share. | 01 Aug 2022 | 68 | 361,612 (0%) | 0% | 59.1 | 4,021 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2022 | 68 | 72,605 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2022 | 9,632 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 154.94 per share. | 01 Aug 2022 | 1,000 | 354,311 (0%) | 0% | 154.9 | 154,940 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 155.27 per share. | 01 Aug 2022 | 1,100 | 355,311 (0%) | 0% | 155.3 | 170,795 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 154.50 per share. | 01 Aug 2022 | 2,601 | 356,411 (0%) | 0% | 154.5 | 401,858 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 153.48 per share. | 01 Aug 2022 | 2,600 | 359,012 (0%) | 0% | 153.5 | 399,052 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 01 Aug 2022 | 9,632 | 361,544 (0%) | 0% | 46.8 | 451,067 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Sale of securities on an exchange or to another person at price $ 155.00 per share. | 12 Jul 2022 | 532 | 11,309 (0%) | 0% | 155 | 82,460 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jul 2022 | 532 | 10,625 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 109.45 per share. | 12 Jul 2022 | 532 | 11,841 (0%) | 0% | 109.4 | 58,227 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 156.95 per share. | 05 Jul 2022 | 1,000 | 353,412 (0%) | 0% | 157.0 | 156,950 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 160.00 per share. | 05 Jul 2022 | 1,500 | 351,912 (0%) | 0% | 160 | 240,000 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 156.65 per share. | 05 Jul 2022 | 5,839 | 354,848 (0%) | 0% | 156.7 | 914,687 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2022 | 9,700 | 9,632 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 05 Jul 2022 | 9,700 | 360,687 (0%) | 0% | 46.8 | 454,251 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 157.13 per share. | 05 Jul 2022 | 436 | 354,412 (0%) | 0% | 157.1 | 68,509 | Ordinary Shares |
| Christopher John Tovey | EVP, COO & Managing Director E | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.02 per share. | 05 Jul 2022 | 4,032 | 19,872 (0%) | 0% | 0.0 | 81 | Ordinary Shares |
| Christopher John Tovey | EVP, COO & Managing Director E | Sale of securities on an exchange or to another person at price $ 160.00 per share. | 05 Jul 2022 | 4,032 | 15,840 (0%) | 0% | 160 | 645,120 | Ordinary Shares |
| Christopher John Tovey | EVP, COO & Managing Director E | Sale of securities on an exchange or to another person at price $ 160.00 per share. | 05 Jul 2022 | 1,177 | 14,663 (0%) | 0% | 160 | 188,320 | Ordinary Shares |
| Christopher John Tovey | EVP, COO & Managing Director E | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2022 | 4,032 | 4,031 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jun 2022 | 8,508 | 11,157 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Head of Europe & Internat | Sale of securities on an exchange or to another person at price $ 155.00 per share. | 27 Jun 2022 | 8,508 | 11,309 (0%) | 0% | 155 | 1,318,740 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 109.45 per share. | 27 Jun 2022 | 8,508 | 19,817 (0%) | 0% | 109.5 | 931,201 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Sale of securities on an exchange or to another person at price $ 155.00 per share. | 08 Jun 2022 | 5,835 | 13,961 (0%) | 0% | 155 | 904,425 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 109.45 per share. | 08 Jun 2022 | 5,835 | 19,796 (0%) | 0% | 109.5 | 638,641 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Internat | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jun 2022 | 5,835 | 19,665 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Head of Europe & Internat | Sale of securities on an exchange or to another person at price $ 155.00 per share. | 08 Jun 2022 | 2,652 | 11,309 (0%) | 0% | 155 | 411,060 | Ordinary Shares |
| Robert Iannone | EVP, Global Head of R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 149.25 per share. | 06 Jun 2022 | 1,295 | 38,109 (0%) | 0% | 149.3 | 193,279 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Sale of securities on an exchange or to another person at price $ 152.59 per share. | 06 Jun 2022 | 101 | 24,754 (0%) | 0% | 152.6 | 15,412 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Sale of securities on an exchange or to another person at price $ 151.87 per share. | 06 Jun 2022 | 1,317 | 24,855 (0%) | 0% | 151.9 | 200,016 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Sale of securities on an exchange or to another person at price $ 150.68 per share. | 06 Jun 2022 | 573 | 26,172 (0%) | 0% | 150.7 | 86,337 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Sale of securities on an exchange or to another person at price $ 149.22 per share. | 06 Jun 2022 | 250 | 26,745 (0%) | 0% | 149.2 | 37,306 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Sale of securities on an exchange or to another person at price $ 148.21 per share. | 06 Jun 2022 | 200 | 26,995 (0%) | 0% | 148.2 | 29,642 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Sale of securities on an exchange or to another person at price $ 152.15 per share. | 06 Jun 2022 | 1,388 | 27,195 (0%) | 0% | 152.1 | 211,184 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Payment of exercise price or tax liability using portion of securities received from the company at price $ 149.25 per share. | 06 Jun 2022 | 1,759 | 28,583 (0%) | 0% | 149.3 | 262,531 | Ordinary Shares |
| Patricia Carr | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 150.26 per share. | 02 Jun 2022 | 131 | 6,234 (0%) | 0% | 150.3 | 19,684 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 145.42 per share. | 01 Jun 2022 | 2,412 | 355,937 (0%) | 0% | 145.4 | 350,753 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 146.05 per share. | 01 Jun 2022 | 1,360 | 354,577 (0%) | 0% | 146.1 | 198,628 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 01 Jun 2022 | 9,700 | 358,349 (0%) | 0% | 46.8 | 454,251 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2022 | 9,700 | 19,332 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 150.00 per share. | 01 Jun 2022 | 1,000 | 350,987 (0%) | 0% | 150 | 150,000 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 149.68 per share. | 01 Jun 2022 | 489 | 351,987 (0%) | 0% | 149.7 | 73,194 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 148.82 per share. | 01 Jun 2022 | 831 | 352,476 (0%) | 0% | 148.8 | 123,669 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 148.13 per share. | 01 Jun 2022 | 1,270 | 353,307 (0%) | 0% | 148.1 | 188,125 | Ordinary Shares |
| Neena M. Patil | Chief Legal Officer (CLO) | Gift of securities by or to the insider at price $ 0.00 per share. | 10 May 2022 | 161 | 32,516 (0%) | 0% | 0 | Ordinary Shares | |
| Neena M. Patil | Chief Legal Officer (CLO) | Sale of securities on an exchange or to another person at price $ 152.15 per share. | 10 May 2022 | 1,000 | 31,600 (0%) | 0% | 152.2 | 152,150 | Ordinary Shares |
| Neena M. Patil | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 153.92 per share. | 06 May 2022 | 296 | 32,677 (0%) | 0% | 153.9 | 45,559 | Ordinary Shares |
| Christopher John Tovey | EVP, COO & Managing Director E | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.22 per share. | 05 May 2022 | 1,096 | 15,840 (0%) | 0% | 153.2 | 167,929 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 02 May 2022 | 9,700 | 355,762 (0%) | 0% | 46.8 | 454,251 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 May 2022 | 9,700 | 29,032 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 158.67 per share. | 02 May 2022 | 1,000 | 348,502 (0%) | 0% | 158.7 | 158,670 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 158.53 per share. | 02 May 2022 | 716 | 349,502 (0%) | 0% | 158.5 | 113,507 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 156.97 per share. | 02 May 2022 | 767 | 350,218 (0%) | 0% | 157.0 | 120,396 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 156.13 per share. | 02 May 2022 | 3,177 | 350,985 (0%) | 0% | 156.1 | 496,025 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 155.34 per share. | 02 May 2022 | 1,600 | 354,162 (0%) | 0% | 155.3 | 248,544 | Ordinary Shares |
| Renee D. Gala | EVP & CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 162.88 per share. | 05 Apr 2022 | 1,633 | 34,995 (0%) | 0% | 162.9 | 265,983 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 158.64 per share. | 04 Apr 2022 | 1,000 | 349,562 (0%) | 0% | 158.6 | 158,640 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Apr 2022 | 9,700 | 38,732 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 160.00 per share. | 04 Apr 2022 | 3,500 | 346,062 (0%) | 0% | 160 | 560,000 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 158.37 per share. | 04 Apr 2022 | 1,294 | 350,562 (0%) | 0% | 158.4 | 204,934 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 157.49 per share. | 04 Apr 2022 | 3,228 | 351,856 (0%) | 0% | 157.5 | 508,362 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 156.33 per share. | 04 Apr 2022 | 1,750 | 355,084 (0%) | 0% | 156.3 | 273,569 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 04 Apr 2022 | 9,700 | 356,834 (0%) | 0% | 46.8 | 454,251 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Mar 2022 | 1,288 | 0 | - | - | Incentive Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.13 per share. | 17 Mar 2022 | 1,288 | 347,134 (0%) | 0% | 59.1 | 76,159 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 44,788 | 367,775 (0%) | 0% | 0 | Ordinary Shares | |
| Bruce C. Cozadd | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.96 per share. | 03 Mar 2022 | 21,929 | 345,846 (0%) | 0% | 154.0 | 3,376,189 | Ordinary Shares |
| Daniel N. Swisher | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.96 per share. | 03 Mar 2022 | 4,802 | 57,251 (0%) | 0% | 154.0 | 739,316 | Ordinary Shares |
| Daniel N. Swisher | President and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 13,507 | 62,053 (0%) | 0% | 0 | Ordinary Shares | |
| Christopher John Tovey | EVP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 7,820 | 16,936 (0%) | 0% | 0 | Ordinary Shares | |
| Renee D. Gala | EVP & CFO | Sale or transfer of securities back to the company at price $ 153.96 per share. | 03 Mar 2022 | 720 | 36,628 (0%) | 0% | 154.0 | 110,851 | Ordinary Shares |
| Renee D. Gala | EVP & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 11,730 | 37,348 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Iannone | EVP, Global Head of R&D and Ch | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 11,374 | 40,584 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Iannone | EVP, Global Head of R&D and Ch | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.96 per share. | 03 Mar 2022 | 1,327 | 39,257 (0%) | 0% | 154.0 | 204,305 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.96 per share. | 03 Mar 2022 | 746 | 30,342 (0%) | 0% | 154.0 | 114,854 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 9,953 | 31,088 (0%) | 0% | 0 | Ordinary Shares | |
| Neena M. Patil | Chief Legal Officer (CLO) and | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.96 per share. | 03 Mar 2022 | 1,228 | 32,973 (0%) | 0% | 154.0 | 189,063 | Ordinary Shares |
| Neena M. Patil | Chief Legal Officer (CLO) and | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 8,886 | 34,201 (0%) | 0% | 0 | Ordinary Shares | |
| Patricia Carr | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 2,488 | 8,296 (0%) | 0% | 0 | Ordinary Shares | |
| Samantha Pearce | SVP, Head of Europe & Interna | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.96 per share. | 03 Mar 2022 | 1,836 | 13,961 (0%) | 0% | 154.0 | 282,671 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Interna | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 3,839 | 15,797 (0%) | 0% | 0 | Ordinary Shares | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 135.73 per share. | 01 Mar 2022 | 3,260 | 332,228 (0%) | 0% | 135.7 | 442,486 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2022 | 9,700 | 48,432 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 150.00 per share. | 01 Mar 2022 | 6,000 | 322,987 (0%) | 0% | 150 | 900,000 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 137.40 per share. | 01 Mar 2022 | 200 | 328,987 (0%) | 0% | 137.4 | 27,481 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 136.73 per share. | 01 Mar 2022 | 3,041 | 329,187 (0%) | 0% | 136.7 | 415,792 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 01 Mar 2022 | 9,700 | 335,488 (0%) | 0% | 46.8 | 454,251 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 138.11 per share. | 01 Feb 2022 | 2,050 | 330,110 (0%) | 0% | 138.1 | 283,134 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2022 | 9,700 | 58,132 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 140.26 per share. | 01 Feb 2022 | 2,186 | 325,788 (0%) | 0% | 140.3 | 306,618 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 139.24 per share. | 01 Feb 2022 | 2,136 | 327,974 (0%) | 0% | 139.2 | 297,416 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 01 Feb 2022 | 9,700 | 332,160 (0%) | 0% | 46.8 | 454,251 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 127.58 per share. | 03 Jan 2022 | 1,181 | 325,251 (0%) | 0% | 127.6 | 150,672 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 126.72 per share. | 03 Jan 2022 | 1,819 | 326,432 (0%) | 0% | 126.7 | 230,504 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2022 | 9,700 | 67,832 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 03 Jan 2022 | 9,700 | 328,251 (0%) | 0% | 46.8 | 454,251 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 129.34 per share. | 03 Jan 2022 | 140 | 322,460 (0%) | 0% | 129.3 | 18,108 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 128.67 per share. | 03 Jan 2022 | 2,651 | 322,600 (0%) | 0% | 128.7 | 341,104 | Ordinary Shares |
| Daniel N. Swisher | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 131.01 per share. | 03 Jan 2022 | 1,624 | 48,546 (0%) | 0% | 131.0 | 212,760 | Ordinary Shares |
| Jennifer Cook | Director | Sale of securities on an exchange or to another person at price $ 121.30 per share. | 02 Dec 2021 | 417 | 4,419 (0%) | 0% | 121.3 | 50,582 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2021 | 9,700 | 77,532 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 123.06 per share. | 01 Dec 2021 | 2,758 | 318,551 (0%) | 0% | 123.1 | 339,413 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 122.38 per share. | 01 Dec 2021 | 3,990 | 321,309 (0%) | 0% | 122.4 | 488,313 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 01 Dec 2021 | 9,700 | 325,299 (0%) | 0% | 46.8 | 454,251 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Sale of securities on an exchange or to another person at price $ 135.01 per share. | 11 Nov 2021 | 2,748 | 21,135 (0%) | 0% | 135.0 | 371,000 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 133.70 per share. | 01 Nov 2021 | 1,893 | 320,199 (0%) | 0% | 133.7 | 253,087 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2021 | 9,700 | 87,232 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 135.45 per share. | 01 Nov 2021 | 2,729 | 315,536 (0%) | 0% | 135.4 | 369,634 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 134.78 per share. | 01 Nov 2021 | 1,934 | 318,265 (0%) | 0% | 134.8 | 260,670 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 01 Nov 2021 | 9,700 | 322,092 (0%) | 0% | 46.8 | 454,251 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 04 Oct 2021 | 9,700 | 318,990 (0%) | 0% | 46.8 | 454,251 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Oct 2021 | 9,700 | 96,932 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 129.87 per share. | 04 Oct 2021 | 6,598 | 312,392 (0%) | 0% | 129.9 | 856,903 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 131.58 per share. | 01 Sep 2021 | 500 | 309,290 (0%) | 0% | 131.6 | 65,790 | Ordinary Shares |
| Patrick G. Enright | Director | Grant, award, or other acquisition of securities at price $ 137.75 per share. | 18 Aug 2021 | 2,000 | 2,000 (0%) | 0% | 137.8 | 275,500 | Ordinary Shares |
| Norbert G. Riedel | Director | Sale of securities on an exchange or to another person at price $ 147.96 per share. | 06 Aug 2021 | 1,306 | 10,399 (0%) | 0% | 148.0 | 193,236 | Ordinary Shares |
| Rick E. Winningham | Director | Sale of securities on an exchange or to another person at price $ 147.96 per share. | 06 Aug 2021 | 1,306 | 7,138 (0%) | 0% | 148.0 | 193,236 | Ordinary Shares |
| Heather Ann McSharry | Director | Sale of securities on an exchange or to another person at price $ 147.96 per share. | 06 Aug 2021 | 1,414 | 11,165 (0%) | 0% | 148.0 | 209,215 | Ordinary Shares |
| Kenneth W. O'Keefe | Director | Sale of securities on an exchange or to another person at price $ 147.96 per share. | 06 Aug 2021 | 1,306 | 19,607 (0%) | 0% | 148.0 | 193,236 | Ordinary Shares |
| Peter P. Gray | Director | Sale of securities on an exchange or to another person at price $ 147.96 per share. | 06 Aug 2021 | 1,414 | 12,852 (0%) | 0% | 148.0 | 209,215 | Ordinary Shares |
| Catherine A. Sohn | Director | Sale of securities on an exchange or to another person at price $ 147.96 per share. | 06 Aug 2021 | 1,306 | 11,562 (0%) | 0% | 148.0 | 193,236 | Ordinary Shares |
| Patricia Carr | SVP, Finance & PAO | Sale of securities on an exchange or to another person at price $ 147.96 per share. | 06 Aug 2021 | 157 | 6,035 (0%) | 0% | 148.0 | 23,230 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Aug 2021 | 2,652 | 0 | - | - | Incentive Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 05 Aug 2021 | 2,652 | 309,790 (0%) | 0% | 46.8 | 124,193 | Ordinary Shares |
| Paul L. Berns | Director | Sale of securities on an exchange or to another person at price $ 154.00 per share. | 05 Aug 2021 | 1,450 | 8,290 (0%) | 0% | 154 | 223,300 | Ordinary Shares |
| Elmar Schnee | Director | Sale of securities on an exchange or to another person at price $ 154.00 per share. | 05 Aug 2021 | 1,632 | 8,270 (0%) | 0% | 154 | 251,328 | Ordinary Shares |
| Neena M. Patil | CLO&SVP Legal and Corp Affairs | Payment of exercise price or tax liability using portion of securities received from the company at price $ 148.49 per share. | 05 Aug 2021 | 993 | 25,233 (0%) | 0% | 148.5 | 147,451 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 169.98 per share. | 02 Aug 2021 | 1,500 | 307,388 (0%) | 0% | 170.0 | 254,970 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 170.00 per share. | 02 Aug 2021 | 250 | 307,138 (0%) | 0% | 170 | 42,500 | Ordinary Shares |
| Patrick G. Enright | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2021 | 2,246 | 22,614 (0%) | 0% | 0 | Ordinary Shares | |
| Norbert G. Riedel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2021 | 2,246 | 11,705 (0%) | 0% | 0 | Ordinary Shares | |
| Rick E. Winningham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2021 | 2,246 | 8,444 (0%) | 0% | 0 | Ordinary Shares | |
| Heather Ann McSharry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2021 | 2,246 | 12,579 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth W. O'Keefe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2021 | 2,246 | 20,913 (0%) | 0% | 0 | Ordinary Shares | |
| Peter P. Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2021 | 2,246 | 14,266 (0%) | 0% | 0 | Ordinary Shares | |
| Seamus C. Mulligan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2021 | 2,246 | 1,157,739 (2%) | 0% | 0 | Ordinary Shares | |
| Catherine A. Sohn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2021 | 2,246 | 12,868 (0%) | 0% | 0 | Ordinary Shares | |
| Jennifer Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2021 | 2,246 | 4,836 (0%) | 0% | 0 | Ordinary Shares | |
| Anne O'Riordan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2021 | 2,246 | 9,711 (0%) | 0% | 0 | Ordinary Shares | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 180.67 per share. | 01 Jul 2021 | 10,850 | 308,888 (0%) | 0% | 180.7 | 1,960,270 | Ordinary Shares |
| Robert Iannone | EVP R&D, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 176.47 per share. | 05 Jun 2021 | 1,206 | 29,086 (0%) | 0% | 176.5 | 212,823 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Payment of exercise price or tax liability using portion of securities received from the company at price $ 176.47 per share. | 05 Jun 2021 | 1,452 | 23,883 (0%) | 0% | 176.5 | 256,234 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 179.07 per share. | 01 Jun 2021 | 1,750 | 319,738 (0%) | 0% | 179.1 | 313,373 | Ordinary Shares |
| Christopher John Tovey | EVP COO & Managing Dir EUR/INT | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2021 | 9,091 | 9,116 (0%) | 0% | 0 | Ordinary Shares | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 170.00 per share. | 03 May 2021 | 500 | 321,341 (0%) | 0% | 170 | 85,000 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 164.24 per share. | 03 May 2021 | 1,500 | 321,841 (0%) | 0% | 164.2 | 246,360 | Ordinary Shares |
| Renee D. Gala | EVP & CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.71 per share. | 05 Apr 2021 | 1,515 | 25,347 (0%) | 0% | 164.7 | 249,536 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 164.96 per share. | 01 Apr 2021 | 1,500 | 323,341 (0%) | 0% | 165.0 | 247,440 | Ordinary Shares |
| Patricia Carr | VP, Finance & PAO | Sale of securities on an exchange or to another person at price $ 161.61 per share. | 08 Mar 2021 | 1,089 | 7,006 (0%) | 0% | 161.6 | 175,988 | Ordinary Shares |
| Patricia Carr | VP, Finance & PAO | Sale of securities on an exchange or to another person at price $ 161.50 per share. | 08 Mar 2021 | 961 | 6,045 (0%) | 0% | 161.5 | 155,202 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.75 per share. | 05 Mar 2021 | 21,516 | 324,841 (0%) | 0% | 164.8 | 3,544,761 | Ordinary Shares |
| Daniel N. Swisher | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.75 per share. | 05 Mar 2021 | 3,718 | 49,961 (0%) | 0% | 164.8 | 612,541 | Ordinary Shares |
| Robert Iannone | EVP R&D, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.75 per share. | 05 Mar 2021 | 741 | 30,145 (0%) | 0% | 164.8 | 122,080 | Ordinary Shares |
| Neena M. Patil | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.75 per share. | 05 Mar 2021 | 691 | 26,147 (0%) | 0% | 164.7 | 113,842 | Ordinary Shares |
| Samantha Pearce | SVP, Head of Europe & Intl | Payment of exercise price or tax liability using portion of securities received from the company at price $ 164.75 per share. | 05 Mar 2021 | 1,402 | 11,958 (0%) | 0% | 164.8 | 230,980 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 170.00 per share. | 01 Mar 2021 | 9,600 | 346,357 (0%) | 0% | 170 | 1,632,000 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 37,925 | 355,957 (0%) | 0% | 0 | Ordinary Shares | |
| Daniel N. Swisher | President and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 11,695 | 53,679 (0%) | 0% | 0 | Ordinary Shares | |
| Renee D. Gala | EVP & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 10,115 | 26,862 (0%) | 0% | 0 | Ordinary Shares | |
| Robert Iannone | EVP, Research & Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 8,535 | 30,886 (0%) | 0% | 0 | Ordinary Shares | |
| Jennifer Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 6,475 | 6,475 | - | - | Non-Qualified Stock Option (right to buy) | |
| Jennifer Cook | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 2,590 | 2,590 (0%) | 0% | 0 | Ordinary Shares | |
| Kim Sablich | EVP & GM, North America | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 8,535 | 25,335 (0%) | 0% | 0 | Ordinary Shares | |
| Neena M. Patil | Chief Legal Officer (CLO) and | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 7,270 | 26,838 (0%) | 0% | 0 | Ordinary Shares | |
| Patricia Carr | VP, Finance & PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 1,895 | 8,095 (0%) | 0% | 0 | Ordinary Shares | |
| Samantha Pearce | SVP, Head of Europe & Intl | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2021 | 3,160 | 13,360 (0%) | 0% | 0 | Ordinary Shares | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 160.00 per share. | 01 Feb 2021 | 250 | 318,032 (0%) | 0% | 160 | 40,000 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 156.15 per share. | 01 Feb 2021 | 1,250 | 318,282 (0%) | 0% | 156.2 | 195,188 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 162.01 per share. | 04 Jan 2021 | 7,950 | 319,532 (0%) | 0% | 162.0 | 1,287,980 | Ordinary Shares |
| Daniel N. Swisher | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 160.40 per share. | 04 Jan 2021 | 1,607 | 41,984 (0%) | 0% | 160.4 | 257,763 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 150.00 per share. | 01 Dec 2020 | 250 | 327,482 (0%) | 0% | 150 | 37,500 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 140.58 per share. | 01 Dec 2020 | 1,000 | 327,732 (0%) | 0% | 140.6 | 140,580 | Ordinary Shares |
| Patrick G. Enright | Director | Sale of securities on an exchange or to another person at price $ 147.00 per share. | 12 Nov 2020 | 5,083 | 21,991 (0%) | 0% | 147.0 | 747,217 | Ordinary Shares |
| Patrick G. Enright | Director | Sale of securities on an exchange or to another person at price $ 145.81 per share. | 12 Nov 2020 | 3,223 | 27,074 (0%) | 0% | 145.8 | 469,946 | Ordinary Shares |
| Patrick G. Enright | Director | Sale of securities on an exchange or to another person at price $ 147.61 per share. | 12 Nov 2020 | 1,623 | 20,368 (0%) | 0% | 147.6 | 239,575 | Ordinary Shares |
| Kenneth W. O'Keefe | Director | Sale of securities on an exchange or to another person at price $ 156.44 per share. | 05 Nov 2020 | 4,513 | 18,667 (0%) | 0% | 156.4 | 706,003 | Ordinary Shares |
| Kenneth W. O'Keefe | Director | Sale of securities on an exchange or to another person at price $ 155.14 per share. | 05 Nov 2020 | 1,746 | 23,180 (0%) | 0% | 155.1 | 270,867 | Ordinary Shares |
| Kenneth W. O'Keefe | Director | Sale of securities on an exchange or to another person at price $ 153.74 per share. | 05 Nov 2020 | 2,740 | 24,926 (0%) | 0% | 153.7 | 421,255 | Ordinary Shares |
| Kenneth W. O'Keefe | Director | Sale of securities on an exchange or to another person at price $ 152.57 per share. | 05 Nov 2020 | 2,001 | 27,666 (0%) | 0% | 152.6 | 305,295 | Ordinary Shares |
| Catherine A. Sohn | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 81.76 per share. | 04 Nov 2020 | 4,500 | 15,122 (0%) | 0% | 81.8 | 367,920 | Ordinary Shares |
| Catherine A. Sohn | Director | Sale of securities on an exchange or to another person at price $ 156.00 per share. | 04 Nov 2020 | 4,500 | 10,622 (0%) | 0% | 156 | 702,000 | Ordinary Shares |
| Catherine A. Sohn | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2020 | 4,500 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Catherine A. Sohn | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2020 | 8,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Catherine A. Sohn | Director | Sale of securities on an exchange or to another person at price $ 152.00 per share. | 04 Nov 2020 | 8,000 | 10,622 (0%) | 0% | 152 | 1,216,000 | Ordinary Shares |
| Catherine A. Sohn | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 46.83 per share. | 04 Nov 2020 | 8,000 | 18,622 (0%) | 0% | 46.8 | 374,640 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 154.00 per share. | 02 Nov 2020 | 2,500 | 328,680 (0%) | 0% | 154 | 385,000 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 145.13 per share. | 02 Nov 2020 | 1,000 | 331,180 (0%) | 0% | 145.1 | 145,130 | Ordinary Shares |
| Patrick G. Enright | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Nov 2020 | 9,929 | 30,297 (0%) | 0% | - | Ordinary Shares | |
| Patrick G. Enright | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Nov 2020 | 9,929 | 0 | - | - | Phantom Stock | |
| Paul L. Berns | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Nov 2020 | 4,691 | 14,431 (0%) | 0% | - | Ordinary Shares | |
| Paul L. Berns | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Nov 2020 | 4,691 | 0 | - | - | Phantom Stock | |
| Paul L. Berns | Director | Sale of securities on an exchange or to another person at price $ 150.90 per share. | 02 Nov 2020 | 3,825 | 9,740 (0%) | 0% | 150.9 | 577,186 | Ordinary Shares |
| Paul L. Berns | Director | Sale of securities on an exchange or to another person at price $ 149.28 per share. | 02 Nov 2020 | 400 | 13,565 (0%) | 0% | 149.3 | 59,711 | Ordinary Shares |
| Paul L. Berns | Director | Sale of securities on an exchange or to another person at price $ 147.44 per share. | 02 Nov 2020 | 466 | 13,965 (0%) | 0% | 147.4 | 68,707 | Ordinary Shares |
| Kenneth W. O'Keefe | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Nov 2020 | 22,249 | 0 | - | - | Phantom Stock | |
| Kenneth W. O'Keefe | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Nov 2020 | 22,249 | 29,667 (0%) | 0% | - | Ordinary Shares | |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 141.94 per share. | 01 Oct 2020 | 4,500 | 332,180 (0%) | 0% | 141.9 | 638,730 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 134.90 per share. | 01 Sep 2020 | 500 | 336,680 (0%) | 0% | 134.9 | 67,450 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Sale of securities on an exchange or to another person at price $ 130.00 per share. | 27 Aug 2020 | 3,000 | 337,180 (0%) | 0% | 130 | 390,000 | Ordinary Shares |
| Patricia Carr | VP, Finance & PAO | Sale of securities on an exchange or to another person at price $ 123.80 per share. | 12 Aug 2020 | 142 | 6,200 (0%) | 0% | 123.8 | 17,580 | Ordinary Shares |
| Patricia Carr | VP, Finance & PAO | Sale of securities on an exchange or to another person at price $ 125.87 per share. | 07 Aug 2020 | 158 | 6,342 (0%) | 0% | 125.9 | 19,887 | Ordinary Shares |
| Patrick G. Enright | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 6,765 | 6,765 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick G. Enright | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 2,705 | 20,368 (0%) | 0% | 0 | Ordinary Shares | |
| Norbert G. Riedel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 2,705 | 10,390 (0%) | 0% | 0 | Ordinary Shares | |
| Norbert G. Riedel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 6,765 | 6,765 | - | - | Non-Qualified Stock Option (right to buy) | |
| Norbert G. Riedel | Director | Sale of securities on an exchange or to another person at price $ 125.87 per share. | 06 Aug 2020 | 931 | 9,459 (0%) | 0% | 125.9 | 117,186 | Ordinary Shares |
| Paul L. Berns | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 6,765 | 6,765 | - | - | Non-Qualified Stock Option (right to buy) | |
| Paul L. Berns | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 2,705 | 10,671 (0%) | 0% | 0 | Ordinary Shares | |
| Paul L. Berns | Director | Sale of securities on an exchange or to another person at price $ 125.87 per share. | 06 Aug 2020 | 931 | 9,740 (0%) | 0% | 125.9 | 117,185 | Ordinary Shares |
| Rick E. Winningham | Director | Sale of securities on an exchange or to another person at price $ 125.87 per share. | 06 Aug 2020 | 931 | 6,198 (0%) | 0% | 125.9 | 117,185 | Ordinary Shares |
| Rick E. Winningham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 6,765 | 6,765 | - | - | Non-Qualified Stock Option (right to buy) | |
| Rick E. Winningham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 2,705 | 7,129 (0%) | 0% | 0 | Ordinary Shares | |
| Heather Ann McSharry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 6,765 | 6,765 | - | - | Non-Qualified Stock Option (right to buy) | |
| Heather Ann McSharry | Director | Sale of securities on an exchange or to another person at price $ 125.87 per share. | 06 Aug 2020 | 1,009 | 10,333 (0%) | 0% | 125.9 | 127,003 | Ordinary Shares |
| Heather Ann McSharry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 2,705 | 11,342 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth W. O'Keefe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 2,705 | 8,349 (0%) | 0% | 0 | Ordinary Shares | |
| Kenneth W. O'Keefe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 6,765 | 6,765 | - | - | Non-Qualified Stock Option (right to buy) | |
| Kenneth W. O'Keefe | Director | Sale of securities on an exchange or to another person at price $ 125.87 per share. | 06 Aug 2020 | 931 | 7,418 (0%) | 0% | 125.9 | 117,186 | Ordinary Shares |
| Peter P. Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 6,765 | 6,765 | - | - | Non-Qualified Stock Option (right to buy) | |
| Peter P. Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 2,705 | 12,020 (0%) | 0% | 0 | Ordinary Shares | |
| Elmar Schnee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 6,765 | 6,765 | - | - | Non-Qualified Stock Option (right to buy) | |
| Elmar Schnee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 2,705 | 9,902 (0%) | 0% | 0 | Ordinary Shares | |
| Seamus C. Mulligan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 2,705 | 1,155,493 (2%) | 0% | 0 | Ordinary Shares | |
| Seamus C. Mulligan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 6,765 | 6,765 | - | - | Non-Qualified Stock Option (right to buy) | |
| Catherine A. Sohn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 6,765 | 6,765 | - | - | Non-Qualified Stock Option (right to buy) | |
| Catherine A. Sohn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 2,705 | 11,553 (0%) | 0% | 0 | Ordinary Shares | |
| Catherine A. Sohn | Director | Sale of securities on an exchange or to another person at price $ 125.87 per share. | 06 Aug 2020 | 931 | 10,622 (0%) | 0% | 125.9 | 117,186 | Ordinary Shares |
| Kim Sablich | EVP & GM, North America | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 38,856 | 38,856 | - | - | Non-Qualified Stock Option (right to buy) | |
| Kim Sablich | EVP & GM, North America | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 3,144 | 3,144 | - | - | Incentive Stock Option (right to buy) | |
| Kim Sablich | EVP & GM, North America | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 16,800 | 16,800 (0%) | 0% | 0 | Ordinary Shares | |
| Anne O'Riordan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 6,765 | 6,765 | - | - | Non-Qualified Stock Option (right to buy) | |
| Anne O'Riordan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Aug 2020 | 2,705 | 7,465 (0%) | 0% | 0 | Ordinary Shares | |
| Neena M. Patil | SVP, General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 122.24 per share. | 05 Aug 2020 | 987 | 19,489 (0%) | 0% | 122.2 | 120,651 | Ordinary Shares |
| Robert Iannone | EVP, Research & Development | Payment of exercise price or tax liability using portion of securities received from the company at price $ 120.65 per share. | 05 Jun 2020 | 943 | 22,204 (0%) | 0% | 120.7 | 113,773 | Ordinary Shares |
| Patricia Carr | VP, Finance & PAO | Sale of securities on an exchange or to another person at price $ 124.00 per share. | 05 Jun 2020 | 138 | 6,500 (0%) | 0% | 124 | 17,112 | Ordinary Shares |
| Seamus C. Mulligan | Director | Purchase of securities on an exchange or from another person at price $ 110.65 per share. | 26 May 2020 | 15,000 | 1,117,788 (1%) | 0% | 110.6 | 1,659,747 | Ordinary Shares |
| Seamus C. Mulligan | Director | Purchase of securities on an exchange or from another person at price $ 112.32 per share. | 26 May 2020 | 11,482 | 1,152,788 (2%) | 0% | 112.3 | 1,289,646 | Ordinary Shares |
| Seamus C. Mulligan | Director | Purchase of securities on an exchange or from another person at price $ 111.56 per share. | 26 May 2020 | 9,884 | 1,141,306 (2%) | 0% | 111.6 | 1,102,682 | Ordinary Shares |
| Seamus C. Mulligan | Director | Purchase of securities on an exchange or from another person at price $ 110.52 per share. | 26 May 2020 | 8,391 | 1,131,422 (2%) | 0% | 110.5 | 927,352 | Ordinary Shares |
| Seamus C. Mulligan | Director | Purchase of securities on an exchange or from another person at price $ 109.55 per share. | 26 May 2020 | 5,243 | 1,123,031 (2%) | 0% | 109.6 | 574,379 | Ordinary Shares |
| Renee D. Gala | EVP & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2020 | 16,600 | 16,600 (0%) | 0% | 0 | Ordinary Shares | |
| Renee D. Gala | EVP & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2020 | 37,848 | 37,848 | - | - | Non-Qualified Stock Option (right to buy) | |
| Renee D. Gala | EVP & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2020 | 3,652 | 3,652 | - | - | Incentive Stock Option (right to buy) | |
| Samantha Pearce | SVP, Europe and Rest of World | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2020 | 25,500 | 25,500 | - | - | Non-Qualified Stock Option (right to buy) | |
| Samantha Pearce | SVP, Europe and Rest of World | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 May 2020 | 10,200 | 10,200 (0%) | 0% | 0 | Ordinary Shares | |
| Michael P Miller | EVP, US Commercial | Sale of securities on an exchange or to another person at price $ 102.17 per share. | 12 Mar 2020 | 1,500 | 22,118 (0%) | 0% | 102.2 | 153,255 | Ordinary Shares |
| Patricia Carr | VP, Finance & PAO | Sale of securities on an exchange or to another person at price $ 102.17 per share. | 12 Mar 2020 | 600 | 6,500 (0%) | 0% | 102.2 | 61,302 | Ordinary Shares |
| Patricia Carr | VP, Finance & PAO | Sale of securities on an exchange or to another person at price $ 111.45 per share. | 06 Mar 2020 | 568 | 7,100 (0%) | 0% | 111.4 | 63,303 | Ordinary Shares |
| Patricia Carr | VP, Finance & PAO | Sale of securities on an exchange or to another person at price $ 119.17 per share. | 06 Mar 2020 | 232 | 7,668 (0%) | 0% | 119.2 | 27,648 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 124.50 per share. | 05 Mar 2020 | 15,071 | 340,033 (0%) | 0% | 124.5 | 1,876,340 | Ordinary Shares |
| Daniel N. Swisher | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 124.50 per share. | 05 Mar 2020 | 1,735 | 43,391 (0%) | 0% | 124.5 | 216,008 | Ordinary Shares |
| Michael P Miller | EVP, US Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 124.50 per share. | 05 Mar 2020 | 2,423 | 23,618 (0%) | 0% | 124.5 | 301,664 | Ordinary Shares |
| Patricia Carr | VP, Finance & PAO | Sale of securities on an exchange or to another person at price $ 119.75 per share. | 03 Mar 2020 | 247 | 8,153 (0%) | 0% | 119.7 | 29,578 | Ordinary Shares |
| Patricia Carr | VP, Finance & PAO | Sale of securities on an exchange or to another person at price $ 118.67 per share. | 03 Mar 2020 | 253 | 7,900 (0%) | 0% | 118.7 | 30,024 | Ordinary Shares |
| Bruce C. Cozadd | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 885 | 885 | - | - | Incentive Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 129,115 | 129,115 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bruce C. Cozadd | Director, Chairman & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2020 | 52,000 | 355,104 (0%) | 0% | 0 | Ordinary Shares |