29,502 XNAS Volume
XNAS 26 Mar, 2025 10:47 AM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Michel Detheux | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 77,000 | 135,903 | - | 0 | Common Stock | |
| Michel Detheux | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 459,000 | 459,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Call | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 24,000 | 161,898 | - | 0 | Common Stock | |
| Matthew Call | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 145,000 | 145,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Gall | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 24,000 | 89,429 | - | 0 | Common Stock | |
| Matthew Gall | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 145,000 | 145,000 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 15,300 | 46,300 | - | 0 | Common Stock | |
| Yvonne McGrath | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2025 | 91,000 | 91,000 | - | - | Stock Option (Right to Buy) | |
| Feltquate David | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2024 | 47,000 | 47,000 | - | 0 | Common Stock | |
| Matthew Gall | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 7.73 per share. | 19 Nov 2024 | 5,000 | 65,429 | - | 7.7 | 38,635 | Common Stock |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Aug 2024 | 442,800 | 442,800 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Aug 2024 | 442,800 | 147,600 | - | - | Stock Option (Right to Buy) | |
| David Feltquate | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2024 | 350,000 | 350,000 | - | - | Stock Option (Right to Buy) | |
| Ann D. Rhoads | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2024 | 24,200 | 24,200 | - | - | Stock Option (Right to Buy) | |
| David L. Hallal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2024 | 24,200 | 24,200 | - | - | Stock Option (Right to Buy) | |
| Tim Van Hauwermeiren | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2024 | 24,200 | 24,200 | - | - | Stock Option (Right to Buy) | |
| Tony W. Ho | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2024 | 24,200 | 24,200 | - | - | Stock Option (Right to Buy) | |
| Aaron I. Davis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2024 | 24,200 | 24,200 | - | - | Stock Option (Right to Buy) | |
| Robert Iannone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2024 | 24,200 | 24,200 | - | - | Stock Option (Right to Buy) | |
| Jill DeSimone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2024 | 24,200 | 24,200 | - | - | Stock Option (Right to Buy) | |
| David K. Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jun 2024 | 24,200 | 24,200 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 590,400 | 590,400 | - | - | Stock Option (Right to Buy) | |
| Matthew Call | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 225,000 | 225,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Gall | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 163,200 | 163,200 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 153,600 | 153,600 | - | - | Stock Option (Right to Buy) | |
| Jill DeSimone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Mar 2024 | 44,766 | 44,766 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2023 | 30,000 | 58,903 | - | 0 | Common Stock | |
| Call Matthew | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2023 | 44,000 | 137,898 | - | 0 | Common Stock | |
| David Lee K. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2023 | 44,766 | 44,766 | - | - | Stock Option (Right to Buy) | |
| McGrath Yvonne | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2023 | 31,000 | 31,000 | - | 0 | Common Stock | |
| Gall Matthew | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Dec 2023 | 41,000 | 60,429 | - | 0 | Common Stock | |
| Ann D. Rhoads | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 22,383 | 22,383 | - | - | Stock Option (Right to Buy) | |
| David Hallal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 22,383 | 22,383 | - | - | Stock Option (Right to Buy) | |
| Tim Van Hauwermeiren | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 22,383 | 22,383 | - | - | Stock Option (Right to Buy) | |
| Robert Iannone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 22,383 | 22,383 | - | - | Stock Option (Right to Buy) | |
| Derek DiRocco | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2023 | 22,383 | 22,383 | - | - | Stock Option (Right to Buy) | |
| Matthew Call | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.95 per share. | 28 Mar 2023 | 40,226 | 93,898 | - | 3.0 | 118,667 | Common Stock |
| Matthew Call | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Mar 2023 | 40,226 | 107,864 | - | - | Stock Option (right to buy) | |
| Michel Detheux | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 346,000 | 346,000 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 09 Mar 2023 | 254,997 | 91,003 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 09 Mar 2023 | 254,997 | 254,997 | - | - | Stock Option (Right to Buy) | |
| Matthew Call | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 130,000 | 130,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Gall | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 130,000 | 130,000 | - | - | Stock Option (Right to Buy) | |
| Joanne Jenkins Lager | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 130,000 | 130,000 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Mar 2023 | 130,000 | 130,000 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 264,375 | 88,125 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 264,375 | 264,375 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2022 | 11,500 | 144,464 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.64 per share. | 18 Apr 2022 | 33 | 26,263 | - | 32.6 | 1,077 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 31.87 per share. | 18 Apr 2022 | 11,467 | 26,296 | - | 31.9 | 365,453 | Common Stock |
| Michel Detheux | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.23 per share. | 18 Apr 2022 | 11,500 | 37,763 | - | 4.2 | 48,645 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 34.11 per share. | 21 Mar 2022 | 9,908 | 28,970 | - | 34.1 | 337,962 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 36.51 per share. | 21 Mar 2022 | 1,548 | 26,263 | - | 36.5 | 56,517 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 35.22 per share. | 21 Mar 2022 | 1,159 | 27,811 | - | 35.2 | 40,820 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 33.44 per share. | 21 Mar 2022 | 5,822 | 38,878 | - | 33.4 | 194,688 | Common Stock |
| Michel Detheux | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2022 | 10,000 | 44,700 | - | 0 | Common Stock | |
| Michel Detheux | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2022 | 352,500 | 352,500 | - | - | Stock Option (Right to Buy) | |
| Matthew Call | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2022 | 85,000 | 85,000 | - | - | Option (right to buy) | |
| Matthew Gall | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2022 | 85,000 | 85,000 | - | - | Stock Option (Right to Buy) | |
| Joanne Jenkins Lager | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.30 per share. | 11 Mar 2022 | 3,500 | 3,500 | - | 4.3 | 15,050 | Common Stock |
| Joanne Jenkins Lager | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 36.01 per share. | 11 Mar 2022 | 3,500 | 0 | - | 36.0 | 126,035 | Common Stock |
| Joanne Jenkins Lager | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2022 | 85,000 | 85,000 | - | - | Stock Option (Right to Buy) | |
| Joanne Jenkins Lager | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2022 | 3,500 | 178,938 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2022 | 85,000 | 85,000 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2022 | 10,000 | 85,123 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.24 per share. | 01 Mar 2022 | 10,000 | 10,000 | - | 4.2 | 42,400 | Common Stock |
| Yvonne McGrath | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 36.76 per share. | 01 Mar 2022 | 10,000 | 0 | - | 36.8 | 367,570 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 35.32 per share. | 23 Feb 2022 | 544 | 34,700 | - | 35.3 | 19,214 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 34.30 per share. | 23 Feb 2022 | 13,956 | 35,244 | - | 34.3 | 478,691 | Common Stock |
| Joanne Jenkins Lager | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.30 per share. | 11 Feb 2022 | 3,500 | 3,500 | - | 4.3 | 15,050 | Common Stock |
| Joanne Jenkins Lager | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Feb 2022 | 3,500 | 182,438 | - | - | Stock Option (right to buy) | |
| Joanne Jenkins Lager | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 36.27 per share. | 11 Feb 2022 | 1,518 | 0 | - | 36.3 | 55,058 | Common Stock |
| Joanne Jenkins Lager | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.52 per share. | 11 Feb 2022 | 1,982 | 1,518 | - | 35.5 | 70,401 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 36.21 per share. | 25 Jan 2022 | 4,412 | 49,200 | - | 36.2 | 159,759 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 35.45 per share. | 25 Jan 2022 | 10,088 | 53,612 | - | 35.5 | 357,620 | Common Stock |
| Joanne Jenkins Lager | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 39.25 per share. | 14 Jan 2022 | 2,777 | 723 | - | 39.2 | 108,997 | Common Stock |
| Joanne Jenkins Lager | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jan 2022 | 3,500 | 185,938 | - | - | Stock Option (Right to Buy) | |
| Joanne Jenkins Lager | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 39.58 per share. | 14 Jan 2022 | 723 | 0 | - | 39.6 | 28,616 | Common Stock |
| Joanne Jenkins Lager | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.30 per share. | 14 Jan 2022 | 3,500 | 3,500 | - | 4.3 | 15,050 | Common Stock |
| Detlev Biniszkiewicz | Director | Sale of securities on an exchange or to another person at price $ 51.90 per share. | 03 Jan 2022 | 3,500 | 0 | - | 51.9 | 181,650 | Common Stock |
| Detlev Biniszkiewicz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2022 | 3,500 | 13,108 | - | - | Stock Option (Right to Buy) | |
| Detlev Biniszkiewicz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.00 per share. | 03 Jan 2022 | 3,500 | 3,500 | - | 19 | 66,500 | Common Stock |
| Joanne Jenkins Lager | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 51.90 per share. | 03 Jan 2022 | 7,000 | 0 | - | 51.9 | 363,300 | Common Stock |
| Joanne Jenkins Lager | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2022 | 7,000 | 189,438 | - | - | Stock Option (Right to Buy) | |
| Joanne Jenkins Lager | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.30 per share. | 03 Jan 2022 | 7,000 | 7,000 | - | 4.3 | 30,100 | Common Stock |
| Matthew Gall | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 46.45 per share. | 27 Dec 2021 | 5,000 | 14,429 | - | 46.5 | 232,250 | Common Stock |
| David Hallal | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.30 per share. | 20 Dec 2021 | 20,000 | 20,000 | - | 4.3 | 86,000 | Common Stock |
| David Hallal | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2021 | 30,000 | 37,039 | - | - | Stock Option (Right to Buy) | |
| David Hallal | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2021 | 20,000 | 114,682 | - | - | Stock Option (Right to Buy) | |
| David Hallal | Director | Sale of securities on an exchange or to another person at price $ 43.57 per share. | 20 Dec 2021 | 50,000 | 0 | - | 43.6 | 2,178,500 | Common Stock |
| David Hallal | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.95 per share. | 20 Dec 2021 | 30,000 | 50,000 | - | 3.0 | 88,500 | Common Stock |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Dec 2021 | 106,200 | 37,800 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Dec 2021 | 776,600 | 776,600 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Dec 2021 | 776,600 | 258,824 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Dec 2021 | 52,700 | 52,700 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Dec 2021 | 52,700 | 17,544 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Dec 2021 | 185,000 | 185,000 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Dec 2021 | 185,000 | 155,964 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Dec 2021 | 313,442 | 313,442 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Dec 2021 | 313,442 | 90,000 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 45.37 per share. | 02 Dec 2021 | 9,493 | 63,700 | - | 45.4 | 430,697 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.62 per share. | 02 Dec 2021 | 5,007 | 73,193 | - | 44.6 | 223,412 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.92 per share. | 02 Dec 2021 | 149 | 78,200 | - | 44.9 | 6,693 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.31 per share. | 02 Dec 2021 | 1,514 | 78,349 | - | 44.3 | 67,085 | Common Stock |
| Michel Detheux | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.30 per share. | 02 Dec 2021 | 1,663 | 79,863 | - | 4.3 | 7,151 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 45.06 per share. | 02 Dec 2021 | 5,580 | 78,200 | - | 45.1 | 251,435 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.15 per share. | 02 Dec 2021 | 13,646 | 83,780 | - | 44.2 | 602,471 | Common Stock |
| Michel Detheux | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.30 per share. | 02 Dec 2021 | 19,226 | 97,426 | - | 4.3 | 82,672 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 43.94 per share. | 02 Dec 2021 | 9,111 | 78,200 | - | 43.9 | 400,337 | Common Stock |
| Michel Detheux | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.30 per share. | 02 Dec 2021 | 9,111 | 87,311 | - | 4.3 | 39,177 | Common Stock |
| Michel Detheux | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2021 | 1,663 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2021 | 19,226 | 61,663 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2021 | 9,111 | 80,889 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Dec 2021 | 106,200 | 106,200 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 36.08 per share. | 22 Nov 2021 | 14,500 | 78,200 | - | 36.1 | 523,160 | Common Stock |
| Michel Detheux | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Nov 2021 | 16,263 | 0 | - | - | Stock Option (right to buy) | |
| Michel Detheux | Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.45 per share. | 22 Nov 2021 | 16,263 | 92,700 | - | 12.4 | 202,474 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.00 per share. | 01 Nov 2021 | 81 | 96,913 | - | 28 | 2,268 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.89 per share. | 01 Nov 2021 | 6,085 | 76,437 | - | 28.9 | 175,777 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.41 per share. | 01 Nov 2021 | 14,391 | 82,522 | - | 28.4 | 408,920 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.00 per share. | 21 Oct 2021 | 196 | 96,994 | - | 28 | 5,488 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.00 per share. | 15 Oct 2021 | 201 | 97,190 | - | 28 | 5,628 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.01 per share. | 15 Oct 2021 | 1,635 | 97,391 | - | 28.0 | 45,796 | Common Stock |
| Matthew Gall | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Oct 2021 | 14,429 | 42,388 | - | - | Stock Option (right to buy) | |
| Matthew Gall | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.16 per share. | 11 Oct 2021 | 14,429 | 19,429 | - | 6.2 | 88,883 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.16 per share. | 23 Sep 2021 | 5,322 | 100,115 | - | 28.2 | 149,862 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.02 per share. | 23 Sep 2021 | 1,089 | 99,026 | - | 28.0 | 30,512 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.12 per share. | 27 Aug 2021 | 4,093 | 125,689 | - | 28.1 | 115,095 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.01 per share. | 27 Aug 2021 | 2,322 | 129,782 | - | 28.0 | 65,039 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.17 per share. | 27 Aug 2021 | 8,248 | 132,104 | - | 28.2 | 232,346 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.06 per share. | 23 Aug 2021 | 7,499 | 141,438 | - | 28.1 | 210,422 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.00 per share. | 23 Aug 2021 | 861 | 140,352 | - | 28.0 | 24,109 | Common Stock |
| Michel Detheux | Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.26 per share. | 23 Aug 2021 | 225 | 141,213 | - | 28.3 | 6,359 | Common Stock |
| Matthew Call | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.95 per share. | 30 Jul 2021 | 53,672 | 53,672 | - | 2.9 | 158,332 | Common Stock |
| Matthew Call | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2021 | 53,672 | 148,090 | - | - | Stock Option (right to buy) | |
| Ann D. Rhoads | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2021 | 16,608 | 16,608 | - | - | Stock Option (Right to Buy) | |
| David Hallal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2021 | 16,608 | 16,608 | - | - | Stock Option (Right to Buy) | |
| Tim Van Hauwermeiren | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2021 | 16,608 | 0 | - | - | Stock Option (Right to Buy) | |
| Robert Iannone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2021 | 4,560 | 4,560 | - | - | Stock Option (Right to Buy) | |
| Detlev Biniszkiewicz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2021 | 16,608 | 16,608 | - | - | Stock Option (Right to Buy) | |
| Derek DiRocco | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2021 | 16,608 | 0 | - | - | Stock Option (Right to Buy) | |
| Matthew Roden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2021 | 16,608 | 0 | - | - | Stock Option (Right to Buy) | |
| Matthew Gall | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 26.09 per share. | 16 Jun 2021 | 5,000 | 5,000 | - | 26.1 | 130,447 | Common Stock |
| Michel Detheux | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 29.26 per share. | 14 Jun 2021 | 3,937 | 148,937 | - | 29.3 | 115,199 | Common Stock |
| Michel Detheux | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 28.38 per share. | 14 Jun 2021 | 25,063 | 152,874 | - | 28.4 | 711,336 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 08 Jun 2021 | 7,927 | 0 | - | 20 | 158,540 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jun 2021 | 7,927 | 95,123 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | VP, Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.23 per share. | 08 Jun 2021 | 7,927 | 7,927 | - | 4.2 | 33,531 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.23 per share. | 01 Jun 2021 | 7,604 | 7,604 | - | 4.2 | 32,165 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 323 | 103,050 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | VP, Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 7,604 | 103,373 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | VP, Research and Development | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 01 Jun 2021 | 323 | 0 | - | 20 | 6,460 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.23 per share. | 01 Jun 2021 | 323 | 323 | - | 4.2 | 1,366 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Sale of securities on an exchange or to another person at price $ 20.18 per share. | 01 Jun 2021 | 7,604 | 0 | - | 20.2 | 153,443 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Sale of securities on an exchange or to another person at price $ 21.92 per share. | 24 May 2021 | 7,927 | 0 | - | 21.9 | 173,796 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 May 2021 | 7,927 | 110,977 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | VP, Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.23 per share. | 24 May 2021 | 7,927 | 7,927 | - | 4.2 | 33,531 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.23 per share. | 17 May 2021 | 7,926 | 7,926 | - | 4.2 | 33,527 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2021 | 7,926 | 118,904 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | VP, Research and Development | Sale of securities on an exchange or to another person at price $ 26.01 per share. | 17 May 2021 | 90 | 0 | - | 26.0 | 2,341 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Sale of securities on an exchange or to another person at price $ 25.43 per share. | 17 May 2021 | 2,029 | 90 | - | 25.4 | 51,602 | Common Stock |
| Yvonne McGrath | VP, Research and Development | Sale of securities on an exchange or to another person at price $ 24.41 per share. | 17 May 2021 | 5,807 | 2,119 | - | 24.4 | 141,777 | Common Stock |
| Robert Iannone | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Apr 2021 | 33,217 | 0 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 144,000 | 144,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Call | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 72,000 | 72,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Gall | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 72,000 | 72,000 | - | - | Stock Option (Right to Buy) | |
| Joanne Jenkins Lager | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 122,000 | 122,000 | - | - | Stock Option (Right to Buy) | |
| Yvonne McGrath | VP, Research and Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 45,000 | 45,000 | - | - | Stock Option (Right to Buy) | |
| Matthew Roden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Nov 2020 | 33,217 | 0 | - | - | Stock Option (Right to Buy) | |
| Ann D. Rhoads | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jul 2020 | 16,608 | 0 | - | - | Stock Option (Right to Buy) | |
| David Hallal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jul 2020 | 16,608 | 0 | - | - | Stock Option (Right to Buy) | |
| Tim Van Hauwermeiren | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jul 2020 | 16,608 | 0 | - | - | Stock Option (Right to Buy) | |
| Detlev Biniszkiewicz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jul 2020 | 16,608 | 0 | - | - | Stock Option (Right to Buy) | |
| Derek DiRocco | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jul 2020 | 16,608 | 0 | - | - | Stock Option (Right to Buy) | |
| Michel Detheux | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jul 2020 | 1,035,424 | 0 | - | - | Stock Option (Right to Buy) |