189.6K XNAS Volume
XNAS 27 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.11 per share. | 24 Mar 2025 | 756 | 186,541 | - | 54.1 | 40,907 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.11 per share. | 24 Mar 2025 | 3,026 | 746,171 | - | 54.1 | 163,737 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.11 per share. | 24 Mar 2025 | 1,956 | 482,308 | - | 54.1 | 105,839 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.01 per share. | 19 Mar 2025 | 941 | 487,676 | - | 54.0 | 50,823 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.02 per share. | 19 Mar 2025 | 5,228 | 188,981 | - | 54.0 | 282,417 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.02 per share. | 19 Mar 2025 | 20,911 | 755,933 | - | 54.0 | 1,129,612 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.02 per share. | 19 Mar 2025 | 13,517 | 488,617 | - | 54.0 | 730,188 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.00 per share. | 19 Mar 2025 | 1,320 | 187,297 | - | 54 | 71,280 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.00 per share. | 19 Mar 2025 | 5,279 | 749,197 | - | 54 | 285,066 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.00 per share. | 19 Mar 2025 | 3,412 | 484,264 | - | 54 | 184,248 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.01 per share. | 19 Mar 2025 | 364 | 188,617 | - | 54.0 | 19,660 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.01 per share. | 19 Mar 2025 | 1,457 | 754,476 | - | 54.0 | 78,693 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.44 per share. | 10 Mar 2025 | 10,733 | 194,209 | - | 54.4 | 584,305 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 55.05 per share. | 10 Mar 2025 | 603 | 529,884 | - | 55.0 | 33,195 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.01 per share. | 10 Mar 2025 | 3,567 | 205,175 | - | 54.0 | 192,654 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.01 per share. | 10 Mar 2025 | 14,267 | 820,707 | - | 54.0 | 770,561 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.01 per share. | 10 Mar 2025 | 9,222 | 530,487 | - | 54.0 | 498,080 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 55.02 per share. | 10 Mar 2025 | 53 | 208,742 | - | 55.0 | 2,916 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 55.01 per share. | 10 Mar 2025 | 211 | 834,974 | - | 55.0 | 11,607 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 55.01 per share. | 10 Mar 2025 | 136 | 539,709 | - | 55.0 | 7,481 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.29 per share. | 10 Mar 2025 | 26,596 | 208,795 | - | 54.3 | 1,443,897 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.29 per share. | 10 Mar 2025 | 106,384 | 835,185 | - | 54.3 | 5,775,587 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.29 per share. | 10 Mar 2025 | 68,766 | 539,845 | - | 54.3 | 3,733,306 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.44 per share. | 10 Mar 2025 | 42,930 | 776,844 | - | 54.4 | 2,337,109 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 54.44 per share. | 10 Mar 2025 | 27,750 | 502,134 | - | 54.4 | 1,510,710 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 55.05 per share. | 10 Mar 2025 | 233 | 204,942 | - | 55.1 | 12,827 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 55.05 per share. | 10 Mar 2025 | 933 | 819,774 | - | 55.1 | 51,362 | Common Stock |
| John D. Quisel | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 54.58 per share. | 18 Feb 2025 | 5,574 | 154,828 | - | 54.6 | 304,229 | Common Stock |
| Jean M. Franchi | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 54.58 per share. | 18 Feb 2025 | 3,136 | 69,530 | - | 54.6 | 171,163 | Common Stock |
| Pamela Stephenson | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 54.58 per share. | 18 Feb 2025 | 3,137 | 69,529 | - | 54.6 | 171,217 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 54.58 per share. | 18 Feb 2025 | 1,638 | 68,498 | - | 54.6 | 89,402 | Common Stock |
| Rahul Khara | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 54.58 per share. | 18 Feb 2025 | 1,161 | 37,583 | - | 54.6 | 63,367 | Common Stock |
| Jonathan Yu | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 54.58 per share. | 18 Feb 2025 | 1,610 | 40,555 | - | 54.6 | 87,874 | Common Stock |
| John D. Quisel | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 117,505 | 117,505 | - | - | Stock Option (Right to Buy) | |
| John D. Quisel | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 78,337 | 160,402 | - | 0 | Common Stock | |
| Jean M. Franchi | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 36,000 | 72,666 | - | 0 | Common Stock | |
| Jean M. Franchi | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 36,000 | 36,000 | - | - | Stock Option (Right to Buy) | |
| Pamela Stephenson | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 36,000 | 36,000 | - | - | Stock Option (Right to Buy) | |
| Pamela Stephenson | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 36,000 | 72,666 | - | 0 | Common Stock | |
| Rahul Khara | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 36,000 | 36,000 | - | - | Stock Option (Right to Buy) | |
| Rahul Khara | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 24,000 | 38,035 | - | 0 | Common Stock | |
| Jonathan Yu | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 24,000 | 42,165 | - | 0 | Common Stock | |
| Jonathan Yu | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Feb 2025 | 36,000 | 36,000 | - | - | Stock Option (Right to Buy) | |
| Rahul Khara | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.69 per share. | 03 Feb 2025 | 7,500 | 21,535 | - | 14.7 | 110,175 | Common Stock |
| Rahul Khara | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 55.39 per share. | 03 Feb 2025 | 5,687 | 15,848 | - | 55.4 | 315,031 | Common Stock |
| Rahul Khara | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 56.01 per share. | 03 Feb 2025 | 1,813 | 14,035 | - | 56.0 | 101,542 | Common Stock |
| Rahul Khara | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 7,500 | 64,804 | - | - | Stock Option (Right to Buy) | |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 4,233 | 0 | - | - | Stock Option (Right to Buy) | |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.65 per share. | 03 Feb 2025 | 4,233 | 44,638 | - | 2.6 | 11,217 | Common Stock |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.65 per share. | 03 Feb 2025 | 1,498 | 46,136 | - | 2.7 | 3,970 | Common Stock |
| William Savage | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2025 | 24,000 | 70,136 | - | 0 | Common Stock | |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 1,498 | 0 | - | - | Stock Option (Right to Buy) | |
| William Savage | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2025 | 36,000 | 36,000 | - | - | Stock Option (Right to Buy) | |
| Rahul Khara | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.69 per share. | 02 Jan 2025 | 7,500 | 21,535 | - | 14.7 | 110,175 | Common Stock |
| Rahul Khara | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 61.96 per share. | 02 Jan 2025 | 4,000 | 17,535 | - | 62.0 | 247,840 | Common Stock |
| Rahul Khara | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 62.95 per share. | 02 Jan 2025 | 1,400 | 16,135 | - | 63.0 | 88,135 | Common Stock |
| Rahul Khara | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 64.13 per share. | 02 Jan 2025 | 2,100 | 14,035 | - | 64.1 | 134,683 | Common Stock |
| Rahul Khara | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 7,500 | 72,304 | - | - | Stock Option (Right to Buy) | |
| John D. Quisel | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 30 Dec 2024 | 13,012 | 85,077 | - | 9.9 | 128,298 | Common Stock |
| John D. Quisel | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Dec 2024 | 10,000 | 215,420 | - | - | Stock Option (Right to Buy) | |
| John D. Quisel | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Dec 2024 | 13,012 | 155,375 | - | - | Stock Option (Right to Buy) | |
| John D. Quisel | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 30 Dec 2024 | 10,000 | 82,065 | - | 1.0 | 10,100 | Common Stock |
| John D. Quisel | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 62.41 per share. | 30 Dec 2024 | 1,900 | 72,065 | - | 62.4 | 118,580 | Common Stock |
| John D. Quisel | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 61.87 per share. | 30 Dec 2024 | 11,112 | 73,965 | - | 61.9 | 687,477 | Common Stock |
| Quisel D. John | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Dec 2024 | 19,820 | 41,830 | - | - | Stock Option (Right to Buy) | |
| D. John Quisel | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 63.80 per share. | 23 Dec 2024 | 4,212 | 72,065 | - | 63.8 | 268,733 | Common Stock |
| John D. Quisel | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 63.12 per share. | 23 Dec 2024 | 12,194 | 76,277 | - | 63.1 | 769,667 | Common Stock |
| Quisel John D. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.65 per share. | 23 Dec 2024 | 19,820 | 91,885 | - | 2.7 | 52,523 | Common Stock |
| D. Quisel John | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 62.38 per share. | 23 Dec 2024 | 3,414 | 88,471 | - | 62.4 | 212,957 | Common Stock |
| Quisel D. John | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2024 | 12,791 | 225,420 | - | - | Stock Option (Right to Buy) | |
| Quisel D. John | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 65.58 per share. | 16 Dec 2024 | 5,767 | 78,870 | - | 65.6 | 378,194 | Common Stock |
| Quisel D. John | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 66.35 per share. | 16 Dec 2024 | 6,305 | 72,565 | - | 66.4 | 418,361 | Common Stock |
| John Quisel D. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 16 Dec 2024 | 12,791 | 84,856 | - | 1.0 | 12,919 | Common Stock |
| D. John Quisel | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 67.20 per share. | 16 Dec 2024 | 500 | 72,065 | - | 67.2 | 33,599 | Common Stock |
| Quisel John D. | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 64.66 per share. | 16 Dec 2024 | 219 | 84,637 | - | 64.7 | 14,160 | Common Stock |
| White William R. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2024 | 1,756 | 0 | - | - | Stock Option (Right to Buy) | |
| White R. William | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2024 | 201 | 1,804 | - | - | Stock Option (Right to Buy) | |
| William White R. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.65 per share. | 02 Dec 2024 | 1,756 | 1,756 | - | 2.6 | 4,653 | Common Stock |
| R. William White | Director | Sale of securities on an exchange or to another person at price $ 64.58 per share. | 02 Dec 2024 | 1,762 | 173 | - | 64.6 | 113,790 | Common Stock |
| R. White William | Director | Sale of securities on an exchange or to another person at price $ 63.50 per share. | 02 Dec 2024 | 22 | 1,935 | - | 63.5 | 1,397 | Common Stock |
| R. William White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 02 Dec 2024 | 201 | 1,957 | - | 9.9 | 1,982 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 65.34 per share. | 02 Dec 2024 | 173 | 0 | - | 65.3 | 11,303 | Common Stock |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 25 Nov 2024 | 5,263 | 45,668 | - | 9.9 | 51,893 | Common Stock |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2024 | 8,920 | 30,004 | - | - | Stock Option (Right to Buy) | |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Nov 2024 | 5,263 | 5,258 | - | - | Stock Option (Right to Buy) | |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 67.02 per share. | 25 Nov 2024 | 1,904 | 40,405 | - | 67.0 | 127,613 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 65.79 per share. | 25 Nov 2024 | 3,542 | 42,309 | - | 65.8 | 233,018 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 64.98 per share. | 25 Nov 2024 | 8,737 | 45,851 | - | 65.0 | 567,696 | Common Stock |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.50 per share. | 25 Nov 2024 | 8,920 | 54,588 | - | 13.5 | 120,420 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 60.16 per share. | 15 Nov 2024 | 1,219 | 40,505 | - | 60.2 | 73,333 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 59.54 per share. | 15 Nov 2024 | 7,839 | 41,724 | - | 59.5 | 466,710 | Common Stock |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 15 Nov 2024 | 9,158 | 49,563 | - | 9.9 | 90,298 | Common Stock |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2024 | 9,158 | 36,034 | - | - | Stock Option (Right to Buy) | |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 61.10 per share. | 15 Nov 2024 | 100 | 40,405 | - | 61.1 | 6,110 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 01 Nov 2024 | 201 | 201 | - | 9.9 | 1,982 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 7,136 | 0 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 201 | 2,005 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 58.94 per share. | 01 Nov 2024 | 5,346 | 0 | - | 58.9 | 315,118 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 57.59 per share. | 01 Nov 2024 | 1,790 | 5,346 | - | 57.6 | 103,089 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 45.69 per share. | 01 Nov 2024 | 7,136 | 7,136 | - | 45.7 | 326,044 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 46.74 per share. | 01 Nov 2024 | 129 | 0 | - | 46.7 | 6,030 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 45.68 per share. | 01 Nov 2024 | 72 | 129 | - | 45.7 | 3,289 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 49.03 per share. | 01 Oct 2024 | 32 | 169 | - | 49.0 | 1,569 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 01 Oct 2024 | 201 | 201 | - | 9.9 | 1,982 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 201 | 2,206 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 52.53 per share. | 01 Oct 2024 | 79 | 0 | - | 52.5 | 4,150 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 51.52 per share. | 01 Oct 2024 | 50 | 79 | - | 51.5 | 2,576 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 50.45 per share. | 01 Oct 2024 | 40 | 129 | - | 50.5 | 2,018 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 47.41 per share. | 16 Sep 2024 | 1,500 | 40,405 | - | 47.4 | 71,115 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 03 Sep 2024 | 201 | 201 | - | 9.9 | 1,982 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 1,756 | 1,756 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 201 | 2,407 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 52.30 per share. | 03 Sep 2024 | 10 | 0 | - | 52.3 | 523 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 51.54 per share. | 03 Sep 2024 | 50 | 10 | - | 51.5 | 2,577 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 50.29 per share. | 03 Sep 2024 | 337 | 60 | - | 50.3 | 16,947 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 49.43 per share. | 03 Sep 2024 | 1,560 | 397 | - | 49.4 | 77,111 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.65 per share. | 03 Sep 2024 | 1,756 | 1,957 | - | 2.6 | 4,653 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 50.59 per share. | 03 Sep 2024 | 1,500 | 41,905 | - | 50.6 | 75,885 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 201 | 2,608 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 43.95 per share. | 01 Aug 2024 | 57 | 0 | - | 43.9 | 2,505 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 43.24 per share. | 01 Aug 2024 | 144 | 57 | - | 43.2 | 6,226 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 01 Aug 2024 | 201 | 201 | - | 9.9 | 1,982 | Common Stock |
| John D. Quisel | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2024 | 3,000 | 238,211 | - | - | Stock Option (Right to Buy) | |
| John D. Quisel | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 08 Jul 2024 | 3,000 | 72,065 | - | 1.0 | 3,030 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 45.06 per share. | 01 Jul 2024 | 18 | 183 | - | 45.1 | 811 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 01 Jul 2024 | 201 | 201 | - | 9.9 | 1,982 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 201 | 2,809 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 46.45 per share. | 01 Jul 2024 | 74 | 0 | - | 46.4 | 3,437 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 45.92 per share. | 01 Jul 2024 | 109 | 74 | - | 45.9 | 5,005 | Common Stock |
| Kevin Bitterman | Director | Purchase of securities on an exchange or from another person at price $ 36.00 per share. | 17 Jun 2024 | 222,223 | 420,549 | - | 36 | 8,000,028 | Common Stock |
| Mona Ashiya | Director | Purchase of securities on an exchange or from another person at price $ 36.00 per share. | 17 Jun 2024 | 28,404 | 608,611 | - | 36 | 1,022,544 | Common Stock |
| Mona Ashiya | Director | Purchase of securities on an exchange or from another person at price $ 36.00 per share. | 17 Jun 2024 | 10,986 | 235,391 | - | 36 | 395,496 | Common Stock |
| Mona Ashiya | Director | Purchase of securities on an exchange or from another person at price $ 36.00 per share. | 17 Jun 2024 | 43,944 | 941,569 | - | 36 | 1,581,984 | Common Stock |
| Georges Gemayel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Liam Ratcliffe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Kevin Bitterman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Mark Chin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Mona Ashiya | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Donald W. Nicholson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jun 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.65 per share. | 03 Jun 2024 | 1,756 | 1,756 | - | 2.6 | 4,653 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 201 | 3,010 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 1,756 | 3,512 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 36.72 per share. | 03 Jun 2024 | 95 | 0 | - | 36.7 | 3,488 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 36.10 per share. | 03 Jun 2024 | 1,755 | 95 | - | 36.1 | 63,359 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 35.15 per share. | 03 Jun 2024 | 107 | 1,850 | - | 35.1 | 3,761 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 03 Jun 2024 | 201 | 1,957 | - | 9.9 | 1,982 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2024 | 201 | 3,211 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 01 May 2024 | 201 | 201 | - | 9.9 | 1,982 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 28.51 per share. | 01 May 2024 | 162 | 39 | - | 28.5 | 4,619 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 29.10 per share. | 01 May 2024 | 39 | 0 | - | 29.1 | 1,135 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Apr 2024 | 1,756 | 5,268 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Apr 2024 | 804 | 3,412 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 11 Apr 2024 | 804 | 2,560 | - | 9.9 | 7,927 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 31.79 per share. | 11 Apr 2024 | 2,482 | 78 | - | 31.8 | 78,897 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 32.18 per share. | 11 Apr 2024 | 78 | 0 | - | 32.2 | 2,510 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.65 per share. | 11 Apr 2024 | 1,756 | 1,756 | - | 2.6 | 4,653 | Common Stock |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Apr 2024 | 8,777 | 1,498 | - | - | Stock Option (Right to Buy) | |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.65 per share. | 10 Apr 2024 | 21,870 | 43,405 | - | 2.7 | 57,956 | Common Stock |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Apr 2024 | 13,093 | 4,233 | - | - | Stock Option (Right to Buy) | |
| Kevin Bitterman | Director | Sale of securities on an exchange or to another person at price $ 73.50 per share. | 05 Mar 2024 | 26,157 | 677,503 | - | 73.5 | 1,922,540 | Common Stock |
| Pamela Stephenson | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2024 | 55,000 | 55,000 | - | - | Stock Option (Right to Buy) | |
| Pamela Stephenson | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2024 | 36,666 | 36,666 | - | 0 | Common Stock | |
| M. Franchi Jean | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2024 | 55,000 | 55,000 | - | - | Stock Option (Right to Buy) | |
| Jean Franchi M. | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2024 | 36,666 | 36,666 | - | 0 | Common Stock | |
| Bitterman Kevin | Director | Sale of securities on an exchange or to another person at price $ 67.65 per share. | 23 Jan 2024 | 20,000 | 198,326 | - | 67.7 | 1,353,000 | Common Stock |
| Bitterman Kevin | Director | Sale of securities on an exchange or to another person at price $ 67.65 per share. | 23 Jan 2024 | 82,500 | 703,660 | - | 67.7 | 5,581,125 | Common Stock |
| Kevin Bitterman | Director | Sale of securities on an exchange or to another person at price $ 64.00 per share. | 10 Jan 2024 | 20,000 | 786,160 | - | 64 | 1,280,000 | Common Stock |
| John D. Quisel | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2024 | 99,550 | 99,550 | - | - | Stock Option (Right to Buy) | |
| John D. Quisel | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2024 | 66,365 | 69,065 | - | 0 | Common Stock | |
| Joanne Bryce | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2024 | 27,250 | 27,250 | - | - | Stock Option (Right to Buy) | |
| Joanne Bryce | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2024 | 18,165 | 23,665 | - | 0 | Common Stock | |
| William Savage | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2024 | 27,800 | 27,800 | - | - | Stock Option (Right to Buy) | |
| William Savage | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2024 | 18,535 | 21,535 | - | 0 | Common Stock | |
| Rahul Khara | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2024 | 14,035 | 14,035 | - | 0 | Common Stock | |
| Rahul Khara | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2024 | 21,050 | 21,050 | - | - | Stock Option (Right to Buy) | |
| Jonathan Yu | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2024 | 27,250 | 27,250 | - | - | Stock Option (Right to Buy) | |
| Jonathan Yu | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2024 | 18,165 | 18,165 | - | 0 | Common Stock | |
| John D. Quisel | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 29 Dec 2023 | 2,700 | 2,700 | - | 1.0 | 2,727 | Common Stock |
| John Quisel D. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Dec 2023 | 2,700 | 241,211 | - | - | Stock Option (Right to Buy) | |
| Bryce Joanne | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 27 Dec 2023 | 3,000 | 5,500 | - | 9.9 | 29,580 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2023 | 3,000 | 73,745 | - | - | Stock Option (Right to Buy) | |
| Ashiya Mona | Director | Sale of securities on an exchange or to another person at price $ 59.24 per share. | 18 Dec 2023 | 1,724 | 0 | - | 59.2 | 102,130 | Common Stock |
| Mona Ashiya | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 38.00 per share. | 18 Dec 2023 | 1,724 | 1,724 | - | 38 | 65,512 | Common Stock |
| Mona Ashiya | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2023 | 1,724 | 0 | - | - | Stock Options (Right to Buy) | |
| Ashiya Mona | Director | Sale of securities on an exchange or to another person at price $ 56.75 per share. | 14 Dec 2023 | 228,500 | 897,625 | - | 56.8 | 12,967,375 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 56.75 per share. | 14 Dec 2023 | 147,600 | 580,207 | - | 56.8 | 8,376,300 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 56.75 per share. | 14 Dec 2023 | 57,100 | 224,405 | - | 56.8 | 3,240,425 | Common Stock |
| Kevin Bitterman | Director | Sale of securities on an exchange or to another person at price $ 59.99 per share. | 12 Dec 2023 | 3,508 | 826,749 | - | 60.0 | 210,445 | Common Stock |
| Bitterman Kevin | Director | Sale of securities on an exchange or to another person at price $ 65.10 per share. | 12 Dec 2023 | 18,615 | 836,856 | - | 65.1 | 1,211,837 | Common Stock |
| Bitterman Kevin | Director | Sale of securities on an exchange or to another person at price $ 59.87 per share. | 12 Dec 2023 | 20,823 | 861,401 | - | 59.9 | 1,246,673 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 63.73 per share. | 12 Dec 2023 | 1,091 | 20,320 | - | 63.7 | 69,532 | Common Stock |
| Ashiya Mona | Director | Sale of securities on an exchange or to another person at price $ 58.56 per share. | 12 Dec 2023 | 14,100 | 281,505 | - | 58.6 | 825,696 | Common Stock |
| William White R. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.86 per share. | 12 Dec 2023 | 5,427 | 26,511 | - | 9.9 | 53,510 | Common Stock |
| Bitterman Kevin | Director | Sale of securities on an exchange or to another person at price $ 62.42 per share. | 12 Dec 2023 | 4,155 | 856,824 | - | 62.4 | 259,355 | Common Stock |
| Kevin Bitterman | Director | Sale of securities on an exchange or to another person at price $ 59.74 per share. | 12 Dec 2023 | 120 | 806,160 | - | 59.7 | 7,169 | Common Stock |
| Kevin Bitterman | Director | Sale of securities on an exchange or to another person at price $ 60.99 per share. | 12 Dec 2023 | 422 | 860,979 | - | 61.0 | 25,738 | Common Stock |
| Bitterman Kevin | Director | Sale of securities on an exchange or to another person at price $ 65.77 per share. | 12 Dec 2023 | 6,599 | 830,257 | - | 65.8 | 434,016 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 60.16 per share. | 12 Dec 2023 | 3,600 | 295,605 | - | 60.2 | 216,576 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 65.22 per share. | 12 Dec 2023 | 2,500 | 2,500 | - | 65.2 | 163,062 | Common Stock |
| Ashiya Mona | Director | Sale of securities on an exchange or to another person at price $ 57.73 per share. | 12 Dec 2023 | 100 | 1,126,125 | - | 57.7 | 5,773 | Common Stock |
| Ashiya Mona | Director | Sale of securities on an exchange or to another person at price $ 58.56 per share. | 12 Dec 2023 | 36,400 | 727,907 | - | 58.6 | 2,131,584 | Common Stock |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2023 | 7,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Kevin Bitterman | Director | Sale of securities on an exchange or to another person at price $ 63.78 per share. | 12 Dec 2023 | 688 | 855,471 | - | 63.8 | 43,881 | Common Stock |
| R. William White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.50 per share. | 12 Dec 2023 | 7,000 | 33,511 | - | 13.5 | 94,500 | Common Stock |
| Ashiya Mona | Director | Sale of securities on an exchange or to another person at price $ 60.16 per share. | 12 Dec 2023 | 14,400 | 1,182,425 | - | 60.2 | 866,304 | Common Stock |
| William R. White | Director | Sale of securities on an exchange or to another person at price $ 66.10 per share. | 12 Dec 2023 | 4,057 | 0 | - | 66.1 | 268,151 | Common Stock |
| Bryce Joanne | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2023 | 2,500 | 2,253 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2023 | 21,084 | 7,024 | - | - | Stock Option (Right to Buy) | |
| White William R. | Director | Sale of securities on an exchange or to another person at price $ 59.44 per share. | 12 Dec 2023 | 12,100 | 21,411 | - | 59.4 | 719,214 | Common Stock |
| White R. William | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.65 per share. | 12 Dec 2023 | 21,084 | 21,084 | - | 2.7 | 55,873 | Common Stock |
| Ashiya Mona | Director | Sale of securities on an exchange or to another person at price $ 57.73 per share. | 12 Dec 2023 | 100 | 727,807 | - | 57.7 | 5,773 | Common Stock |
| Bryce Joanne | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.65 per share. | 12 Dec 2023 | 2,500 | 5,000 | - | 2.7 | 6,625 | Common Stock |
| R. White William | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2023 | 5,427 | 4,216 | - | - | Stock Option (Right to Buy) | |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 60.16 per share. | 12 Dec 2023 | 9,300 | 764,307 | - | 60.2 | 559,488 | Common Stock |
| Mona Ashiya | Director | Sale of securities on an exchange or to another person at price $ 58.56 per share. | 12 Dec 2023 | 56,200 | 1,126,225 | - | 58.6 | 3,291,072 | Common Stock |
| White William R. | Director | Sale of securities on an exchange or to another person at price $ 65.26 per share. | 12 Dec 2023 | 16,263 | 4,057 | - | 65.3 | 1,061,341 | Common Stock |
| Bitterman Kevin | Director | Sale of securities on an exchange or to another person at price $ 62.90 per share. | 12 Dec 2023 | 665 | 856,159 | - | 62.9 | 41,829 | Common Stock |
| Kevin Bitterman | Director | Sale of securities on an exchange or to another person at price $ 58.27 per share. | 12 Dec 2023 | 20,429 | 806,280 | - | 58.3 | 1,190,398 | Common Stock |
| Bitterman Kevin | Director | Sale of securities on an exchange or to another person at price $ 60.50 per share. | 12 Dec 2023 | 40 | 826,709 | - | 60.5 | 2,420 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 56.55 per share. | 05 Dec 2023 | 1,293 | 2,600 | - | 56.5 | 73,115 | Common Stock |
| Bryce Joanne | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2023 | 526 | 0 | - | - | Stock Option (Right to Buy) | |
| Joanne Bryce | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 57.06 per share. | 05 Dec 2023 | 100 | 2,500 | - | 57.1 | 5,706 | Common Stock |
| Bryce Joanne | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2023 | 755 | 752 | - | - | Stock Option (Right to Buy) | |
| Bryce Joanne | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 05 Dec 2023 | 526 | 4,286 | - | 1.0 | 531 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 55.29 per share. | 05 Dec 2023 | 1,148 | 3,893 | - | 55.3 | 63,478 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 05 Dec 2023 | 755 | 5,041 | - | 1.0 | 763 | Common Stock |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.65 per share. | 21 Aug 2023 | 3,000 | 3,000 | - | 2.7 | 7,950 | Common Stock |
| William Savage | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Aug 2023 | 3,000 | 17,326 | - | - | Stock Option (Right to Buy) | |
| Kevin Bitterman | Director | Sale of securities on an exchange or to another person at price $ 52.40 per share. | 15 Aug 2023 | 72,931 | 882,224 | - | 52.4 | 3,821,584 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 53.96 per share. | 15 Aug 2023 | 1,839 | 0 | - | 54.0 | 99,240 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 53.26 per share. | 15 Aug 2023 | 2,125 | 1,839 | - | 53.3 | 113,175 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 52.27 per share. | 15 Aug 2023 | 3,708 | 3,964 | - | 52.3 | 193,820 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 48.90 per share. | 09 Aug 2023 | 3,200 | 12,741 | - | 48.9 | 156,481 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 50.91 per share. | 09 Aug 2023 | 1,481 | 7,672 | - | 50.9 | 75,401 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 50.22 per share. | 09 Aug 2023 | 3,588 | 9,153 | - | 50.2 | 180,182 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2023 | 4,521 | 1,507 | - | - | Stock Option (Right to Buy) | |
| Joanne Bryce | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 01 Aug 2023 | 4,521 | 5,781 | - | 1.0 | 4,566 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 49.63 per share. | 01 Aug 2023 | 3,067 | 2,714 | - | 49.6 | 152,213 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 50.50 per share. | 01 Aug 2023 | 1,454 | 1,260 | - | 50.5 | 73,420 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 51.23 per share. | 28 Jun 2023 | 359 | 1,260 | - | 51.2 | 18,391 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 49.30 per share. | 28 Jun 2023 | 4,808 | 6,524 | - | 49.3 | 237,042 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jun 2023 | 7,880 | 526 | - | - | Stock Option (Right to Buy) | |
| Joanne Bryce | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.01 per share. | 28 Jun 2023 | 7,880 | 11,332 | - | 1.0 | 7,959 | Common Stock |
| Joanne Bryce | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 50.50 per share. | 28 Jun 2023 | 4,905 | 1,619 | - | 50.5 | 247,681 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 28 Jun 2023 | 1,300 | 17,505 | - | 50.0 | 65,004 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 50.72 per share. | 28 Jun 2023 | 1,564 | 15,941 | - | 50.7 | 79,327 | Common Stock |
| William Savage | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 49.20 per share. | 28 Jun 2023 | 1,520 | 18,805 | - | 49.2 | 74,783 | Common Stock |
| Brian MacDonald | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 49.24 per share. | 28 Jun 2023 | 2,247 | 25,153 | - | 49.2 | 110,649 | Common Stock |
| Brian MacDonald | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 50.38 per share. | 28 Jun 2023 | 1,900 | 23,253 | - | 50.4 | 95,730 | Common Stock |
| Brian MacDonald | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 50.80 per share. | 28 Jun 2023 | 953 | 22,300 | - | 50.8 | 48,415 | Common Stock |
| Brian MacDonald | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 44.37 per share. | 28 Jun 2023 | 736 | 21,564 | - | 44.4 | 32,656 | Common Stock |
| Brian MacDonald | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 45.49 per share. | 28 Jun 2023 | 2,230 | 19,334 | - | 45.5 | 101,453 | Common Stock |
| Brian MacDonald | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 46.51 per share. | 28 Jun 2023 | 1,934 | 17,400 | - | 46.5 | 89,952 | Common Stock |
| Brian MacDonald | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 47.24 per share. | 28 Jun 2023 | 200 | 17,200 | - | 47.2 | 9,448 | Common Stock |
| Brian MacDonald | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 44.85 per share. | 28 Jun 2023 | 2,923 | 14,277 | - | 44.9 | 131,102 | Common Stock |
| Brian MacDonald | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 45.45 per share. | 28 Jun 2023 | 1,401 | 12,876 | - | 45.5 | 63,676 | Common Stock |
| Brian MacDonald | Chief Innovation Officer | Sale of securities on an exchange or to another person at price $ 46.76 per share. | 28 Jun 2023 | 600 | 12,276 | - | 46.8 | 28,058 | Common Stock |
| Georges Gemayel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2023 | 7,136 | 7,136 | - | - | Stock Option (Right to Buy) | |
| Liam Ratcliffe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2023 | 7,136 | 7,136 | - | - | Stock Option (Right to Buy) | |
| Kevin Bitterman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2023 | 7,136 | 7,136 | - | - | Stock Option (Right to Buy) | |
| Mark Chin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2023 | 7,136 | 7,136 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2023 | 7,136 | 7,136 | - | - | Stock Option (Right to Buy) | |
| Mona Ashiya | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2023 | 7,136 | 7,136 | - | - | Stock Option (Right to Buy) | |
| Donald W. Nicholson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2023 | 7,136 | 7,136 | - | - | Stock Option (Right to Buy) | |
| Mona Ashiya | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 23.00 per share. | 15 Feb 2023 | 37,049 | 773,607 | - | 23 | 852,127 | Common Stock |
| Mona Ashiya | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 23.00 per share. | 15 Feb 2023 | 14,329 | 299,205 | - | 23 | 329,567 | Common Stock |
| Mona Ashiya | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 23.00 per share. | 15 Feb 2023 | 57,318 | 1,196,825 | - | 23 | 1,318,314 | Common Stock |
| Georges Gemayel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 7,000 | 7,000 | - | - | Stock Option (Right to Buy) | |
| Liam Ratcliffe | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 7,000 | 7,000 | - | - | Stock Option (Right to Buy) | |
| John D. Quisel | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 132,002 | 132,002 | - | - | Stock Option (Right to Buy) | |
| Kevin Bitterman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 7,000 | 7,000 | - | - | Stock Option (Right to Buy) | |
| Mark Chin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 7,000 | 7,000 | - | - | Stock Option (Right to Buy) | |
| William R. White | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 7,000 | 7,000 | - | - | Stock Option (Right to Buy) | |
| Mona Ashiya | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 7,000 | 7,000 | - | - | Stock Option (Right to Buy) | |
| Jay T. Backstrom | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 7,000 | 7,000 | - | - | Stock Option (Right to Buy) | |
| Donald W. Nicholson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 7,000 | 7,000 | - | - | Stock Option (Right to Buy) | |
| Joanne Bryce | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 33,847 | 33,847 | - | - | Stock Option (Right to Buy) | |
| William Savage | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 38,924 | 38,924 | - | - | Stock Option (Right to Buy) | |
| Rahul Khara | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 28,770 | 28,770 | - | - | Stock Option (Right to Buy) | |
| Jonathan Yu | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 33,847 | 33,847 | - | - | Stock Option (Right to Buy) | |
| Brian MacDonald | Chief Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Dec 2022 | 33,847 | 33,847 | - | - | Stock Option (Right to Buy) | |
| Brian Piekos | CFO | Grant, award, or other acquisition of securities at price $ 1.09 per share. | 31 May 2022 | 9,960 | 17,615 | - | 1.1 | 10,856 | Common Stock |
| Brian Piekos | CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jan 2022 | 280,876 | 280,876 | - | - | Restricted Stock Units | |
| Georges Gemayel | Director, Executive Chair of the Board | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 793,274 | 793,274 | - | - | Stock Option (Right to Buy) | |
| Jason Patrick Meyenburg | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2022 | 123,600 | 123,600 | - | - | Restricted Stock Units | |
| Georges Gemayel | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2021 | 23,514 | 23,514 | - | - | Stock Option (Right to Buy) | |
| Georges Gemayel | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2021 | 17,245 | 17,245 | - | - | Stock Option (Right to Buy) | |
| Brian Piekos | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Oct 2021 | 90,720 | 90,720 | - | - | Restricted Stock Units | |
| Carl L Gordon | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Oct 2021 | 17,245 | 17,245 | - | - | Stock Option (Right to Buy) | |
| David Charles Lubner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Oct 2021 | 17,245 | 17,245 | - | - | Stock Option (Right to Buy) | |
| Jason P. Rhodes | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Oct 2021 | 17,245 | 17,245 | - | - | Stock Option (Right to Buy) | |
| Tuyen Ong | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Oct 2021 | 17,245 | 17,245 | - | - | Stock Option (Right to Buy) | |
| Jim Tananbaum | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Oct 2021 | 17,245 | 17,245 | - | - | Stock Option (Right to Buy) | |
| Jason Patrick Meyenburg | Director, President & CEO | Purchase of securities on an exchange or from another person at price $ 9.46 per share. | 14 May 2021 | 13,000 | 13,000 | - | 9.5 | 122,929 | Common Stock |
| Brian Piekos | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 9.46 per share. | 14 May 2021 | 7,655 | 7,655 | - | 9.5 | 72,432 | Common Stock |
| Georges Gemayel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Apr 2021 | 45,466 | 45,466 | - | - | Stock Option (Right to Buy) | |
| Walter Strapps | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2021 | 9,000 | 9,000 | - | - | Stock Option (Right to Buy) | |
| Samuel B. Barone | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Apr 2021 | 255,212 | 255,212 | - | - | Stock Option (Right to Buy) | |
| Brian Piekos | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Apr 2021 | 377,734 | 377,734 | - | - | Stock Option (Right to Buy) | |
| David Charles Lubner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Mar 2021 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| David Charles Lubner | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Mar 2021 | 58,855 | 58,855 | - | - | Stock Option (Right to Buy) | |
| Tuyen Ong | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Mar 2021 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Walter Strapps | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 99,133 | 99,133 | - | - | Stock Option (Right to Buy) | |
| Scott Lauder | Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2021 | 272,615 | 272,615 | - | - | Stock Option (Right to Buy) | |
| Precillia Redmond | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2021 | 25,489 | 25,489 | - | - | Stock Option (Right to Buy) | |
| Tuyen Ong | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2021 | 58,855 | 58,855 | - | - | Stock Option (Right to Buy) | |
| Jason Patrick Meyenburg | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2021 | 1,124,832 | 1,124,832 | - | - | Stock Option (Right to Buy) | |
| Jim Tananbaum | Director | 05 Feb 2021 | 2,928,750 | 2,928,750 | - | 0 | Common Stock | ||
| Jim Tananbaum | Director | 05 Feb 2021 | 2,928,750 | 0 | - | - | Common Stock | ||
| Jim Tananbaum | Director | Grant, award, or other acquisition of securities at price $ 10.00 per share. | 05 Feb 2021 | 1,500,000 | 1,500,000 | - | 10 | 15,000,000 | Common Stock |
| Marc Uknis | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2021 | 277,117 | 277,117 | - | - | Stock Option (Right to Buy) | |
| Scott Lauder | Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2021 | 243,996 | 243,996 | - | - | Stock Option (Right to Buy) | |
| Precillia Redmond | Chief People Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2021 | 77,450 | 77,450 | - | - | Stock Option (Right to Buy) | |
| Walter Strapps | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2021 | 79,094 | 79,094 | - | - | Stock Option (Right to Buy) |