119.4K XNAS Volume
XNAS 18 Mar, 2025 10:50 AM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.32 per share. | 11 Mar 2025 | 140 | 180,980 (0%) | 0% | 32.3 | 4,525 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 415 | 99,492 (0%) | 0% | 28.2 | 11,708 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 320 | 93,466 (0%) | 0% | 28.2 | 9,028 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 437 | 181,120 (0%) | 0% | 28.2 | 12,328 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 554 | 56,799 (0%) | 0% | 28.2 | 15,629 | Common Stock |
| Eric E. Swayze | EVP Research | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 415 | 48,432 (0%) | 0% | 28.2 | 11,708 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Other type of transaction at price $ 28.21 per share. | 28 Feb 2025 | 414 | 55,465 (0%) | 0% | 28.2 | 11,680 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 32.35 per share. | 20 Feb 2025 | 1,207 | 56,245 (0%) | 0% | 32.3 | 39,046 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 31.65 per share. | 04 Feb 2025 | 38,843 | 180,683 (0%) | 0% | 31.7 | 1,229,463 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 31.62 per share. | 04 Feb 2025 | 6,165 | 57,452 (0%) | 0% | 31.6 | 194,939 | Common Stock |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 3,714 | 49,384 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 32.20 per share. | 30 Jan 2025 | 1,484 | 61,056 (0%) | 0% | 32.2 | 47,780 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 4,032 | 62,540 (0%) | 0% | 0 | Common Stock | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 32.40 per share. | 30 Jan 2025 | 1,406 | 99,077 (0%) | 0% | 32.4 | 45,561 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 3,820 | 100,483 (0%) | 0% | 0 | Common Stock | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 32.46 per share. | 30 Jan 2025 | 1,327 | 93,146 (0%) | 0% | 32.5 | 43,079 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 3,607 | 94,473 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 25,372 | 232,768 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.45 per share. | 30 Jan 2025 | 13,242 | 219,526 (0%) | 0% | 32.4 | 429,655 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 32.44 per share. | 30 Jan 2025 | 1,523 | 110,500 (0%) | 0% | 32.4 | 49,404 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 4,138 | 112,023 (0%) | 0% | 0 | Common Stock | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 32.49 per share. | 30 Jan 2025 | 1,406 | 63,617 (0%) | 0% | 32.5 | 45,685 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jan 2025 | 3,820 | 65,023 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 32.31 per share. | 30 Jan 2025 | 1,367 | 48,017 (0%) | 0% | 32.3 | 44,162 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 18,901 | 60,724 | - | - | Restricted Stock Unit | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 18,901 | 103,735 (0%) | 0% | 0 | Common Stock | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 32.86 per share. | 15 Jan 2025 | 7,072 | 96,663 (0%) | 0% | 32.9 | 232,407 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 64,801 | - | - | Performance Restricted Stock Units | |
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 79,625 | - | - | Restricted Stock Unit | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 18,011 | 97,618 (0%) | 0% | 0 | Common Stock | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 18,011 | 38,489 | - | - | Restricted Stock Unit | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 56,500 | - | - | Restricted Stock Unit | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 63,482 | - | - | Performance Restricted Stock Units | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 32.90 per share. | 15 Jan 2025 | 6,752 | 90,866 (0%) | 0% | 32.9 | 222,114 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 73,448 | 240,841 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 73,448 | 252,159 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 129,395 | 325,607 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 169,950 | 630,201 | - | - | Performance Restricted Stock Units | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 32.63 per share. | 15 Jan 2025 | 33,445 | 207,396 (0%) | 0% | 32.6 | 1,091,444 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 23,887 | 84,669 | - | - | Restricted Stock Unit | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 23,887 | 116,755 (0%) | 0% | 0 | Common Stock | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 32.81 per share. | 15 Jan 2025 | 8,870 | 107,885 (0%) | 0% | 32.8 | 290,989 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 31,000 | 86,635 | - | - | Performance Restricted Stock Units | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 46,500 | 108,556 | - | - | Restricted Stock Unit | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 80,414 | - | - | Restricted Stock Unit | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 19,690 | 68,563 (0%) | 0% | 0 | Common Stock | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 32.83 per share. | 15 Jan 2025 | 7,360 | 61,203 (0%) | 0% | 32.8 | 241,629 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 64,801 | - | - | Performance Restricted Stock Units | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 19,690 | 60,724 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 1,931 | 7,939 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 1,931 | 1,931 (0%) | 0% | 0 | Common Stock | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 18,700 | 18,700 | - | - | Performance Restricted Stock Units | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 28,050 | 28,050 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 49 | 622 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 19,111 | 52,824 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 32.84 per share. | 15 Jan 2025 | 7,154 | 45,670 (0%) | 0% | 32.8 | 234,959 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 49 | 206 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 32.68 per share. | 15 Jan 2025 | 22 | 184 (0%) | 0% | 32.7 | 719 | Common Stock |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 64,482 | - | - | Performance Restricted Stock Units | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 79,728 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 19,111 | 60,617 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 245 | 671 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 32.70 per share. | 15 Jan 2025 | 3,401 | 25,017 (0%) | 0% | 32.7 | 111,213 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 8,787 | 28,418 (0%) | 0% | 0 | Common Stock | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 2,460 | 8,324 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 3,750 | 10,784 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 8,787 | 77,348 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 86,135 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 51,290 | - | - | Performance Restricted Stock Units | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 32.70 per share. | 15 Jan 2025 | 1,029 | 3,071 (0%) | 0% | 32.7 | 33,648 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 2,460 | 4,100 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 17,372 | 65,031 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 32.79 per share. | 15 Jan 2025 | 6,523 | 58,508 (0%) | 0% | 32.8 | 213,889 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 65,437 | - | - | Performance Restricted Stock Units | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 78,308 | - | - | Restricted Stock Unit | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 17,372 | 60,936 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 32.70 per share. | 15 Jan 2025 | 5,400 | 55,051 (0%) | 0% | 32.7 | 176,580 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 14,283 | 60,451 (0%) | 0% | 0 | Common Stock | |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 14,283 | 63,090 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 33,000 | 77,373 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 22,000 | 53,338 | - | - | Performance Restricted Stock Units | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | 15 Jan 2025 | 22,000 | 22,000 | - | - | Performance Restricted Stock Units | ||
| Shannon L. Devers | EVP, Chief Human Resources Ofc | 15 Jan 2025 | 12,295 | 63,226 | - | - | Restricted Stock Unit | ||
| Shannon L. Devers | EVP, Chief Human Resources Ofc | 15 Jan 2025 | 12,295 | 20,204 (0%) | 0% | 0 | Common Stock | ||
| Shannon L. Devers | EVP, Chief Human Resources Ofc | 15 Jan 2025 | 4,267 | 15,937 (0%) | 0% | 32.8 | 139,855 | Common Stock | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | 15 Jan 2025 | 33,000 | 75,521 | - | - | Restricted Stock Unit | ||
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 86,263 | 86,263 | - | - | Non-Qualified Stock Option (right to buy) | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 31,000 | 31,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 18,700 | 18,700 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 163 | 163 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 2,500 | 2,500 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | 02 Jan 2025 | 22,000 | 22,000 | - | - | Non-Qualified Stock Option (right to buy) | ||
| Michael Hayden | Director | Purchase of securities on an exchange or from another person at price $ 36.23 per share. | 23 Dec 2024 | 2,500 | 35,219 (0%) | 0% | 36.2 | 90,583 | Common Stock |
| Michael Hayden | Director | Purchase of securities on an exchange or from another person at price $ 36.20 per share. | 23 Dec 2024 | 2,500 | 32,719 (0%) | 0% | 36.2 | 90,496 | Common Stock |
| Joseph Loscalzo | Director | Sale of securities on an exchange or to another person at price $ 37.86 per share. | 12 Nov 2024 | 13,508 | 32,251 (0%) | 0% | 37.9 | 511,426 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 38.05 per share. | 12 Nov 2024 | 6,630 | 167,393 (0%) | 0% | 38.1 | 252,294 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 37.92 per share. | 12 Nov 2024 | 1,194 | 33,713 (0%) | 0% | 37.9 | 45,278 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 38.32 per share. | 15 Oct 2024 | 53 | 157 (0%) | 0% | 38.3 | 2,031 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2024 | 125 | 210 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2024 | 125 | 426 | - | - | Restricted Stock Unit | |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | 15 Oct 2024 | 11,280 | 42,521 | - | - | Restricted Stock Unit | ||
| Shannon L. Devers | EVP, Chief Human Resourses Ofc | 29 Sep 2024 | 15,040 | 15,040 | - | - | Non-Qualified Stock Option (right to buy) | ||
| Richard S. Geary | EVP, Chief Development Officer | Other type of transaction at price $ 38.64 per share. | 30 Aug 2024 | 11 | 84,834 (0%) | 0% | 38.6 | 425 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Other type of transaction at price $ 38.64 per share. | 30 Aug 2024 | 177 | 79,607 (0%) | 0% | 38.6 | 6,839 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Other type of transaction at price $ 38.64 per share. | 30 Aug 2024 | 140 | 174,023 (0%) | 0% | 38.6 | 5,410 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Other type of transaction at price $ 38.64 per share. | 30 Aug 2024 | 246 | 48,873 (0%) | 0% | 38.6 | 9,506 | Common Stock |
| Eric E. Swayze | EVP Research | Other type of transaction at price $ 38.64 per share. | 30 Aug 2024 | 11 | 34,907 (0%) | 0% | 38.6 | 425 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Other type of transaction at price $ 38.67 per share. | 30 Aug 2024 | 12 | 46,168 (0%) | 0% | 38.7 | 464 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 49.63 per share. | 28 Aug 2024 | 331 | 84,823 (0%) | 0% | 49.6 | 16,428 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 49.16 per share. | 28 Aug 2024 | 320 | 85,154 (0%) | 0% | 49.2 | 15,731 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 48.00 per share. | 05 Aug 2024 | 2,430 | 85,508 (0%) | 0% | 48 | 116,640 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.42 per share. | 16 Jul 2024 | 12,000 | 12,000 (0%) | 0% | 24.4 | 293,040 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2024 | 12,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 16 Jul 2024 | 12,000 | 0 (0%) | 0% | 50 | 600,000 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 87,265 (0%) | 0% | 0 | Common Stock | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 132,756 (0%) | 0% | 0 | Common Stock | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 45,759 (0%) | 0% | 0 | Common Stock | |
| Joseph Loscalzo | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 42,007 (0%) | 0% | 0 | Common Stock | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 151,934 (0%) | 0% | 0 | Common Stock | |
| Allene M. Diaz | Director | Sale of securities on an exchange or to another person at price $ 48.94 per share. | 15 Jul 2024 | 900 | 16,453 (0%) | 0% | 48.9 | 44,044 | Common Stock |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 4,079 | - | - | Restricted Stock Unit | |
| Allene M. Diaz | Director | Sale of securities on an exchange or to another person at price $ 50.17 per share. | 15 Jul 2024 | 737 | 15,716 (0%) | 0% | 50.2 | 36,975 | Common Stock |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2024 | 4,677 | 17,353 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joan E. Herman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael Hayden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael Hayden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Michael J. Yang | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 9,870 | - | - | Restricted Stock Unit | |
| Allene M. Diaz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 10,111 | 10,111 | - | - | Non-Qualified Stock Option (right to buy) | |
| Allene M. Diaz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 4,079 | 8,756 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 35.53 per share. | 17 Jun 2024 | 16,000 | 163,257 (0%) | 0% | 35.5 | 568,480 | Common Stock |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jun 2024 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Spencer R. Berthelsen | Director | Sale of securities on an exchange or to another person at price $ 40.29 per share. | 17 Jun 2024 | 16,000 | 147,257 (0%) | 0% | 40.3 | 644,640 | Common Stock |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 35.53 per share. | 09 May 2024 | 16,000 | 128,079 (0%) | 0% | 35.5 | 568,480 | Common Stock |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 May 2024 | 16,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.57 per share. | 03 May 2024 | 1,318 | 4,682 (0%) | 0% | 42.6 | 56,110 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.90 per share. | 03 May 2024 | 930 | 0 (0%) | 0% | 42.9 | 39,893 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.55 per share. | 03 May 2024 | 1,070 | 930 (0%) | 0% | 42.5 | 45,526 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.98 per share. | 03 May 2024 | 731 | 2,000 (0%) | 0% | 43.0 | 31,416 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.59 per share. | 03 May 2024 | 1,269 | 2,731 (0%) | 0% | 42.6 | 54,044 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.94 per share. | 03 May 2024 | 682 | 4,000 (0%) | 0% | 42.9 | 29,288 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2024 | 10,838 | 53,135 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 41.60 per share. | 15 Apr 2024 | 4,006 | 19,631 (0%) | 0% | 41.6 | 166,641 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2024 | 10,838 | 23,637 (0%) | 0% | 0 | Common Stock | |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2024 | 1,875 | 44,373 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 41.66 per share. | 15 Apr 2024 | 905 | 46,156 (0%) | 0% | 41.7 | 37,698 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2024 | 1,875 | 47,061 (0%) | 0% | 0 | Common Stock | |
| Richard S. Geary | Officer Level 14 | Other type of transaction at price $ 34.43 per share. | 29 Feb 2024 | 604 | 87,938 (0%) | 0% | 34.4 | 20,793 | Common Stock |
| C. Frank Bennett | Officer Level 14 | Other type of transaction at price $ 34.43 per share. | 29 Feb 2024 | 383 | 79,462 (0%) | 0% | 34.4 | 13,185 | Common Stock |
| Brett P. Monia | Director, CEO Level 15 | Other type of transaction at price $ 34.43 per share. | 29 Feb 2024 | 538 | 174,289 (0%) | 0% | 34.4 | 18,521 | Common Stock |
| Eric E. Swayze | Officer Level 14 | Other type of transaction at price $ 34.42 per share. | 29 Feb 2024 | 605 | 34,929 (0%) | 0% | 34.4 | 20,827 | Common Stock |
| Brian Birchler | Vice President Level 14 | Other type of transaction at price $ 34.43 per share. | 29 Feb 2024 | 604 | 45,186 (0%) | 0% | 34.4 | 20,793 | Common Stock |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2024 | 65,203 | 65,203 | - | - | Non-Qualified Stock Option (right to buy) | |
| Monia P. Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.49 per share. | 16 Feb 2024 | 387 | 173,751 (0%) | 0% | 44.5 | 17,219 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 50.04 per share. | 02 Feb 2024 | 1,995 | 87,300 (0%) | 0% | 50.0 | 99,836 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 49.52 per share. | 02 Feb 2024 | 1,885 | 79,047 (0%) | 0% | 49.5 | 93,337 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.37 per share. | 02 Feb 2024 | 23,907 | 173,732 (0%) | 0% | 49.4 | 1,180,348 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.37 per share. | 02 Feb 2024 | 23,907 | 173,732 (0%) | 0% | 49.4 | 1,180,348 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 49.54 per share. | 02 Feb 2024 | 2,162 | 92,868 (0%) | 0% | 49.5 | 107,105 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 49.67 per share. | 02 Feb 2024 | 1,995 | 48,627 (0%) | 0% | 49.7 | 99,099 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 49.56 per share. | 02 Feb 2024 | 1,940 | 34,291 (0%) | 0% | 49.6 | 96,149 | Common Stock |
| Onaiza Cadoret-Manier | EVP,Chf GL Pdt Str & Oper Ofc | Sale of securities on an exchange or to another person at price $ 49.60 per share. | 02 Feb 2024 | 2,162 | 35,788 (0%) | 0% | 49.6 | 107,240 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 49.59 per share. | 02 Feb 2024 | 2,106 | 47,659 (0%) | 0% | 49.6 | 104,437 | Common Stock |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 4,140 | 37,950 (0%) | 0% | 0 | Common Stock | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 49.59 per share. | 01 Feb 2024 | 2,071 | 49,812 (0%) | 0% | 49.6 | 102,701 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 20,416 | 197,639 (0%) | 0% | 0 | Common Stock | |
| S. Geary Richard | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 3,820 | 89,295 (0%) | 0% | 0 | Common Stock | |
| L. Elizabeth Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 49.54 per share. | 01 Feb 2024 | 2,125 | 92,905 (0%) | 0% | 49.5 | 105,272 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 3,609 | 80,932 (0%) | 0% | 0 | Common Stock | |
| C. Bennett Frank | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 49.52 per share. | 01 Feb 2024 | 1,853 | 79,079 (0%) | 0% | 49.5 | 91,752 | Common Stock |
| Richard Geary S. | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 50.04 per share. | 01 Feb 2024 | 1,961 | 87,334 (0%) | 0% | 50.0 | 98,135 | Common Stock |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Sale of securities on an exchange or to another person at price $ 49.60 per share. | 01 Feb 2024 | 2,125 | 35,825 (0%) | 0% | 49.6 | 105,404 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 4,033 | 51,883 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.37 per share. | 01 Feb 2024 | 23,501 | 174,138 (0%) | 0% | 49.4 | 1,160,303 | Common Stock |
| O'Neil R. Patrick | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 3,820 | 50,622 (0%) | 0% | 0 | Common Stock | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 4,140 | 95,030 (0%) | 0% | 0 | Common Stock | |
| R. Patrick O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 49.67 per share. | 01 Feb 2024 | 1,961 | 48,661 (0%) | 0% | 49.7 | 97,410 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 25,372 | 177,223 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 52.00 per share. | 31 Jan 2024 | 10,773 | 32,516 (0%) | 0% | 52 | 560,196 | Common Stock |
| Swayze E. Eric | EVP Research | Sale of securities on an exchange or to another person at price $ 49.56 per share. | 31 Jan 2024 | 1,907 | 34,324 (0%) | 0% | 49.6 | 94,513 | Common Stock |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 3,715 | 36,231 (0%) | 0% | 0 | Common Stock | |
| R. O'Neil Patrick | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 51.75 per share. | 25 Jan 2024 | 6,450 | 46,802 (0%) | 0% | 51.8 | 333,788 | Common Stock |
| P. Monia Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 51.75 per share. | 25 Jan 2024 | 2,285 | 151,851 (0%) | 0% | 51.8 | 118,249 | Common Stock |
| P. Monia Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 32,059 | 154,136 (0%) | 0% | 50.4 | 1,616,319 | Common Stock |
| E. Swayze Eric | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 17,069 | 46,728 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 21 | 551 | - | - | Restricted Stock Unit | |
| S. Richard Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 19,852 | 92,813 (0%) | 0% | 0 | Common Stock | |
| Elizabeth Hougen L. | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 22,487 | 99,573 (0%) | 0% | 0 | Common Stock | |
| E. Eric Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 50.44 per share. | 16 Jan 2024 | 9 | 85 (0%) | 0% | 50.4 | 454 | Common Stock |
| T. Joseph Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 564 | 1,640 (0%) | 0% | 50.4 | 28,435 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 1,353 | 2,204 (0%) | 0% | 0 | Common Stock | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 15,162 | 53,332 (0%) | 0% | 0 | Common Stock | |
| C. Bennett Frank | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 18,314 | 23,500 | - | - | Restricted Stock Unit | |
| T. Joseph Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 1,460 | 12,799 (0%) | 0% | 50.4 | 73,609 | Common Stock |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 5,564 | 33,810 (0%) | 0% | 50.4 | 280,520 | Common Stock |
| Baroldi T. Joseph | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 3,688 | 14,259 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 5,482 | 47,850 (0%) | 0% | 50.4 | 276,386 | Common Stock |
| C. Bennett Frank | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 18,314 | 84,068 (0%) | 0% | 0 | Common Stock | |
| S. Geary Richard | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 19,852 | 46,625 | - | - | Restricted Stock Unit | |
| C. Bennett Frank | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 6,745 | 77,323 (0%) | 0% | 50.4 | 340,063 | Common Stock |
| Birchler Brian | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 12,080 | 46,248 | - | - | Restricted Stock Unit | |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 15,062 | 39,374 (0%) | 0% | 0 | Common Stock | |
| R. Patrick O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 20,641 | 47,414 | - | - | Restricted Stock Unit | |
| L. Hougen Elizabeth | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 22,487 | 62,056 | - | - | Restricted Stock Unit | |
| Baroldi Joseph T. | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 3,688 | 63,973 | - | - | Restricted Stock Unit | |
| R. O'Neil Patrick | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 7,744 | 53,252 (0%) | 0% | 50.4 | 390,429 | Common Stock |
| Richard Geary S. | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 7,338 | 85,475 (0%) | 0% | 50.4 | 369,960 | Common Stock |
| Swayze Eric E. | EVP Research | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 6,296 | 43,289 (0%) | 0% | 50.4 | 317,425 | Common Stock |
| Birchler Brian | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 12,080 | 49,079 (0%) | 0% | 0 | Common Stock | |
| Patrick O'Neil R. | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 20,641 | 60,996 (0%) | 0% | 0 | Common Stock | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 15,162 | 45,308 | - | - | Restricted Stock Unit | |
| L. Hougen Elizabeth | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 8,683 | 90,890 (0%) | 0% | 50.4 | 437,771 | Common Stock |
| Monia P. Brett | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 68,084 | 186,195 (0%) | 0% | 0 | Common Stock | |
| Swayze Eric E. | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 21 | 94 (0%) | 0% | 0 | Common Stock | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 1,353 | 7,034 | - | - | Restricted Stock Unit | |
| Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 15,062 | 66,997 | - | - | Restricted Stock Unit | |
| Swayze Eric E. | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 17,069 | 49,585 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 68,084 | 196,212 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 16 Jan 2024 | 4,497 | 44,582 (0%) | 0% | 50.4 | 226,725 | Common Stock |
| Elizabeth Hougen L. | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 27,000 | 55,635 | - | - | Performance Restricted Stock Units | |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 27,000 | 55,635 | - | - | Performance Restricted Stock Units | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 31,338 | - | - | Performance Restricted Stock Units | |
| Joseph Baroldi T. | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 2,625 | 8,387 | - | - | Restricted Stock Unit | |
| E. Swayze Eric | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 42,482 | - | - | Performance Restricted Stock Units | |
| S. Geary Richard | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 66,477 | - | - | Restricted Stock Unit | |
| Baroldi T. Joseph | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 29,290 | - | - | Performance Restricted Stock Units | |
| Monia P. Brett | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 143,550 | 460,251 | - | - | Performance Restricted Stock Units | |
| Geary S. Richard | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 42,801 | - | - | Performance Restricted Stock Units | |
| Joseph Baroldi T. | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 67,661 | - | - | Restricted Stock Unit | |
| R. Patrick O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 42,801 | - | - | Performance Restricted Stock Units | |
| Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 32,400 | 82,059 | - | - | Restricted Stock Unit | |
| L. Hougen Elizabeth | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 32,400 | 84,543 | - | - | Restricted Stock Unit | |
| Bennett C. Frank | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 41,814 | - | - | Restricted Stock Unit | |
| E. Swayze Eric | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 63,797 | - | - | Restricted Stock Unit | |
| O'Neil R. Patrick | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 68,055 | - | - | Restricted Stock Unit | |
| Swayze E. Eric | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 116 | 572 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 87,435 | 264,296 | - | - | Restricted Stock Unit | |
| Michael Yang J. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 5,791 | 5,791 | - | - | Restricted Stock Unit | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 17,000 | 41,482 | - | - | Performance Restricted Stock Units | |
| Baroldi T. Joseph | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 1,800 | 5,762 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2024 | 20,400 | 58,328 | - | - | Restricted Stock Unit | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2024 | 17,000 | 43,437 | - | - | Performance Restricted Stock Units | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 32.60 per share. | 12 Jan 2024 | 8,000 | 46,170 (0%) | 0% | 32.6 | 260,800 | Common Stock |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Jan 2024 | 20,400 | 60,470 | - | - | Restricted Stock Unit | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 53.50 per share. | 12 Jan 2024 | 8,000 | 38,170 (0%) | 0% | 53.5 | 427,999 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jan 2024 | 8,000 | 24,265 | - | - | Non-Qualified Stock Option (right to buy) | |
| Swayze Eric E. | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 27,200 | 27,200 | - | - | Non-Qualified Stock Option (right to buy) | |
| Cadoret-Manier Onaiza | EVP, Chf GL Pdt Str & Oper Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 43,200 | 43,200 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett Monia P. | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 116,580 | 116,580 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick O'Neil R. | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 27,200 | 27,200 | - | - | Non-Qualified Stock Option (right to buy) | |
| Birchler Brian | EVP, Corp and Development Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 27,200 | 27,200 | - | - | Non-Qualified Stock Option (right to buy) | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 27,200 | 27,200 | - | - | Non-Qualified Stock Option (right to buy) | |
| S. Richard Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 27,200 | 27,200 | - | - | Non-Qualified Stock Option (right to buy) | |
| E. Eric Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 154 | 154 | - | - | Non-Qualified Stock Option (right to buy) | |
| L. Hougen Elizabeth | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 43,200 | 43,200 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 27,200 | 27,200 | - | - | Non-Qualified Stock Option (right to buy) | |
| Baroldi T. Joseph | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 3,500 | 3,500 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Bennett Frank | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2024 | 27,200 | 27,200 | - | - | Non-Qualified Stock Option (right to buy) | |
| L. Elizabeth Hougen | EVP, Finance & CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 50.50 per share. | 28 Dec 2023 | 43,798 | 77,086 (0%) | 0% | 50.5 | 2,211,799 | Common Stock |
| Birchler Brian | EVP, Corp and Development Ops | Payment of exercise price or tax liability using portion of securities received from the company at price $ 50.50 per share. | 28 Dec 2023 | 11,029 | 36,999 (0%) | 0% | 50.5 | 556,965 | Common Stock |
| Eric Swayze E. | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 28 Dec 2023 | 27,100 | 59,616 (0%) | 0% | 47.3 | 1,282,914 | Common Stock |
| Birchler Brian | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2023 | 11,500 | 15,482 | - | - | Non-Qualified Stock Option (right to buy) | |
| L. Elizabeth Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2023 | 45,225 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric Swayze E. | EVP Research | Sale of securities on an exchange or to another person at price $ 50.19 per share. | 28 Dec 2023 | 27,100 | 32,516 (0%) | 0% | 50.2 | 1,360,081 | Common Stock |
| L. Hougen Elizabeth | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 28 Dec 2023 | 45,225 | 120,884 (0%) | 0% | 47.3 | 2,140,952 | Common Stock |
| E. Eric Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2023 | 27,100 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Birchler Brian | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 28 Dec 2023 | 11,500 | 48,028 (0%) | 0% | 47.3 | 544,410 | Common Stock |
| Parshall B. Lynne | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 26 Dec 2023 | 25,113 | 107,701 (0%) | 0% | 47.3 | 1,188,849 | Common Stock |
| Parshall B. Lynne | Director | Sale of securities on an exchange or to another person at price $ 50.23 per share. | 26 Dec 2023 | 50,000 | 82,588 (0%) | 0% | 50.2 | 2,511,515 | Common Stock |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 26 Dec 2023 | 25,000 | 61,052 (0%) | 0% | 47.3 | 1,183,500 | Common Stock |
| Lynne Parshall B. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Dec 2023 | 25,113 | 92,525 | - | - | Non-Qualified Stock Option (right to buy) | |
| B. Parshall Lynne | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 26 Dec 2023 | 42,525 | 125,113 (0%) | 0% | 47.3 | 2,013,134 | Common Stock |
| Patrick O'Neil R. | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 26 Dec 2023 | 20,825 | 61,180 (0%) | 0% | 47.3 | 985,856 | Common Stock |
| B. Parshall Lynne | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Dec 2023 | 50,000 | 42,525 | - | - | Non-Qualified Stock Option (right to buy) | |
| Lynne B. Parshall | Director | Sale of securities on an exchange or to another person at price $ 51.46 per share. | 26 Dec 2023 | 25,113 | 82,588 (0%) | 0% | 51.5 | 1,292,390 | Common Stock |
| B. Parshall Lynne | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 26 Dec 2023 | 50,000 | 132,588 (0%) | 0% | 47.3 | 2,367,000 | Common Stock |
| B. Lynne Parshall | Director | Sale of securities on an exchange or to another person at price $ 50.19 per share. | 26 Dec 2023 | 42,525 | 82,588 (0%) | 0% | 50.2 | 2,134,223 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 51.46 per share. | 26 Dec 2023 | 20,825 | 40,355 (0%) | 0% | 51.5 | 1,071,717 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Dec 2023 | 25,000 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| R. O'Neil Patrick | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Dec 2023 | 20,825 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Schneider Eugene | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 51.46 per share. | 26 Dec 2023 | 25,000 | 36,052 (0%) | 0% | 51.5 | 1,286,575 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Dec 2023 | 42,525 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Frank Bennett C. | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2023 | 16,113 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Frank C. Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 20 Dec 2023 | 16,113 | 81,867 (0%) | 0% | 47.3 | 762,789 | Common Stock |
| C. Bennett Frank | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 20 Dec 2023 | 6,500 | 72,254 (0%) | 0% | 47.3 | 307,710 | Common Stock |
| P. Monia Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.29 per share. | 20 Dec 2023 | 17,500 | 118,111 (0%) | 0% | 49.3 | 862,577 | Common Stock |
| Monia P. Brett | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2023 | 6,500 | 17,500 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 49.29 per share. | 20 Dec 2023 | 4,112 | 72,961 (0%) | 0% | 49.3 | 202,681 | Common Stock |
| Brett Monia P. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 20 Dec 2023 | 6,500 | 124,611 (0%) | 0% | 47.3 | 307,710 | Common Stock |
| Brett Monia P. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 20 Dec 2023 | 17,500 | 135,611 (0%) | 0% | 47.3 | 828,450 | Common Stock |
| S. Richard Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2023 | 4,112 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bennett Frank C. | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2023 | 6,500 | 16,113 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 49.29 per share. | 20 Dec 2023 | 16,113 | 65,754 (0%) | 0% | 49.3 | 794,211 | Common Stock |
| Monia Brett P. | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.64 per share. | 20 Dec 2023 | 6,500 | 118,111 (0%) | 0% | 49.6 | 322,643 | Common Stock |
| P. Brett Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2023 | 17,500 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Geary S. Richard | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2023 | 6,500 | 4,112 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard Geary S. | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 20 Dec 2023 | 6,500 | 79,461 (0%) | 0% | 47.3 | 307,710 | Common Stock |
| Frank C. Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 49.64 per share. | 20 Dec 2023 | 6,500 | 65,754 (0%) | 0% | 49.6 | 322,643 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 49.64 per share. | 20 Dec 2023 | 6,500 | 72,961 (0%) | 0% | 49.6 | 322,643 | Common Stock |
| Richard Geary S. | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 20 Dec 2023 | 4,112 | 77,073 (0%) | 0% | 47.3 | 194,662 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 50.19 per share. | 14 Dec 2023 | 4,042 | 72,961 (0%) | 0% | 50.2 | 202,856 | Common Stock |
| C. Bennett Frank | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2023 | 14,002 | 31,223 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 49.21 per share. | 14 Dec 2023 | 6,571 | 72,961 (0%) | 0% | 49.2 | 323,381 | Common Stock |
| Michael J. Yang | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2023 | 12,356 | 12,356 | - | - | Non-Qualified Stock Option (right to buy) | |
| Monia Brett P. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2023 | 9,140 | 24,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Bennett Frank | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.19 per share. | 14 Dec 2023 | 8,610 | 65,754 (0%) | 0% | 50.2 | 432,110 | Common Stock |
| Bennett C. Frank | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2023 | 8,610 | 22,613 | - | - | Non-Qualified Stock Option (right to buy) | |
| Richard Geary S. | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 14 Dec 2023 | 6,571 | 79,532 (0%) | 0% | 47.3 | 311,071 | Common Stock |
| Bennett Frank C. | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 49.21 per share. | 14 Dec 2023 | 14,002 | 65,754 (0%) | 0% | 49.2 | 689,085 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.21 per share. | 14 Dec 2023 | 14,860 | 118,111 (0%) | 0% | 49.2 | 731,310 | Common Stock |
| Frank C. Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 14 Dec 2023 | 8,610 | 74,364 (0%) | 0% | 47.3 | 407,597 | Common Stock |
| Monia P. Brett | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.19 per share. | 14 Dec 2023 | 9,140 | 118,111 (0%) | 0% | 50.2 | 458,709 | Common Stock |
| Monia P. Brett | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2023 | 14,860 | 33,140 | - | - | Non-Qualified Stock Option (right to buy) | |
| S. Richard Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2023 | 4,042 | 10,612 | - | - | Non-Qualified Stock Option (right to buy) | |
| Bennett Frank C. | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 14 Dec 2023 | 14,002 | 79,756 (0%) | 0% | 47.3 | 662,855 | Common Stock |
| Geary S. Richard | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 14 Dec 2023 | 4,042 | 77,003 (0%) | 0% | 47.3 | 191,348 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2023 | 6,571 | 14,654 | - | - | Non-Qualified Stock Option (right to buy) | |
| P. Brett Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 14 Dec 2023 | 14,860 | 132,971 (0%) | 0% | 47.3 | 703,472 | Common Stock |
| Monia Brett P. | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 47.34 per share. | 14 Dec 2023 | 9,140 | 127,251 (0%) | 0% | 47.3 | 432,688 | Common Stock |
| Allene M. Diaz | Director | Sale of securities on an exchange or to another person at price $ 41.05 per share. | 01 Aug 2023 | 657 | 12,676 (0%) | 0% | 41.1 | 26,970 | Common Stock |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 87,255 (0%) | 0% | 0 | Common Stock | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 4,677 | - | - | Restricted Stock Unit | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 10,010 | - | - | Restricted Stock Unit | |
| B. Lynne Parshall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 92,588 (0%) | 0% | 0 | Common Stock | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 106,746 (0%) | 0% | 0 | Common Stock | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 4,677 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 10,010 | - | - | Restricted Stock Unit | |
| Joseph H. Wender | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 112,079 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 23,901 (0%) | 0% | 0 | Common Stock | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 4,677 | - | - | Restricted Stock Unit | |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 10,010 | - | - | Restricted Stock Unit | |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 42.00 per share. | 17 Jul 2023 | 3,555 | 20,346 (0%) | 0% | 42 | 149,310 | Common Stock |
| Joseph Klein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 18,568 (0%) | 0% | 0 | Common Stock | |
| Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 10,010 | - | - | Restricted Stock Unit | |
| Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 35,749 (0%) | 0% | 0 | Common Stock | |
| Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 41,082 (0%) | 0% | 0 | Common Stock | |
| Joseph Loscalzo | Director, Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 4,677 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 31,997 (0%) | 0% | 0 | Common Stock | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 4,677 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 10,010 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 37,330 (0%) | 0% | 0 | Common Stock | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 4,677 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 10,010 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 147,257 (0%) | 0% | 0 | Common Stock | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 141,924 (0%) | 0% | 0 | Common Stock | |
| Michael Hayden | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 24,886 (0%) | 0% | 0 | Common Stock | |
| Michael Hayden | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 30,219 (0%) | 0% | 0 | Common Stock | |
| Michael Hayden | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 1,777 | 10,010 | - | - | Restricted Stock Unit | |
| Michael Hayden | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 4,677 | - | - | Restricted Stock Unit | |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 13,333 (0%) | 0% | 0 | Common Stock | |
| Allene M. Diaz | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jul 2023 | 5,333 | 4,677 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 42.25 per share. | 07 Jul 2023 | 18,650 | 121,724 (0%) | 0% | 42.2 | 787,953 | Common Stock |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 4,677 | 11,787 | - | - | Restricted Stock Unit | |
| B. Lynne Parshall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 10,321 | 10,321 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph H. Wender | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 10,321 | 10,321 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph H. Wender | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 4,677 | 11,787 | - | - | Restricted Stock Unit | |
| Joseph Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 4,677 | 11,787 | - | - | Restricted Stock Unit | |
| Joseph Klein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 10,321 | 10,321 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director, Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 10,321 | 10,321 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph Loscalzo | Director, Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 4,677 | 11,787 | - | - | Restricted Stock Unit | |
| Joan E. Herman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 10,321 | 10,321 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joan E. Herman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 4,677 | 11,787 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 4,677 | 11,787 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 10,321 | 10,321 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael Hayden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 10,321 | 10,321 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael Hayden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 4,677 | 11,787 | - | - | Restricted Stock Unit | |
| Allene M. Diaz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 10,321 | 10,321 | - | - | Non-Qualified Stock Option (right to buy) | |
| Allene M. Diaz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jul 2023 | 4,677 | 10,010 | - | - | Restricted Stock Unit | |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.47 per share. | 20 Jun 2023 | 11,250 | 140,147 (0%) | 0% | 28.5 | 320,288 | Common Stock |
| Spencer R. Berthelsen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jun 2023 | 11,250 | 0 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 41.70 per share. | 24 May 2023 | 1,527 | 40,355 (0%) | 0% | 41.7 | 63,676 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.14 per share. | 22 May 2023 | 2,630 | 140,374 (0%) | 0% | 40.1 | 105,568 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.13 per share. | 22 May 2023 | 2,301 | 143,004 (0%) | 0% | 40.1 | 92,339 | Common Stock |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Sale of securities on an exchange or to another person at price $ 36.50 per share. | 17 Apr 2023 | 2,582 | 24,312 (0%) | 0% | 36.5 | 94,250 | Common Stock |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2023 | 5,667 | 49,659 | - | - | Restricted Stock Unit | |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2023 | 5,667 | 26,894 (0%) | 0% | 0 | Common Stock | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 36.50 per share. | 17 Apr 2023 | 3,880 | 10,571 (0%) | 0% | 36.5 | 141,631 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2023 | 10,838 | 14,451 (0%) | 0% | 0 | Common Stock | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2023 | 10,838 | 47,261 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Sale of securities on an exchange or to another person at price $ 36.50 per share. | 17 Apr 2023 | 672 | 36,528 (0%) | 0% | 36.5 | 24,530 | Common Stock |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2023 | 1,875 | 27,720 | - | - | Restricted Stock Unit | |
| Brian Birchler | EVP, Corp and Development Ops | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2023 | 1,875 | 37,200 (0%) | 0% | 0 | Common Stock | |
| Richard S. Geary | EVP, Chief Development Officer | Other type of transaction at price $ 30.51 per share. | 28 Feb 2023 | 575 | 72,960 (0%) | 0% | 30.5 | 17,546 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Other type of transaction at price $ 30.51 per share. | 28 Feb 2023 | 383 | 70,034 (0%) | 0% | 30.5 | 11,687 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Other type of transaction at price $ 30.52 per share. | 28 Feb 2023 | 163 | 75,659 (0%) | 0% | 30.5 | 4,974 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Other type of transaction at price $ 30.51 per share. | 28 Feb 2023 | 301 | 41,882 (0%) | 0% | 30.5 | 9,185 | Common Stock |
| Eric E. Swayze | EVP Research | Other type of transaction at price $ 30.51 per share. | 28 Feb 2023 | 575 | 32,516 (0%) | 0% | 30.5 | 17,546 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 3,822 | 74,305 (0%) | 0% | 0 | Common Stock | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 40.66 per share. | 03 Feb 2023 | 1,920 | 72,385 (0%) | 0% | 40.7 | 78,070 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 40.57 per share. | 03 Feb 2023 | 1,813 | 69,651 (0%) | 0% | 40.6 | 73,560 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 3,609 | 71,464 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 40.69 per share. | 03 Feb 2023 | 24,651 | 145,305 (0%) | 0% | 40.7 | 1,003,153 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 25,372 | 169,956 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 17,210 | 144,584 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 6,511 | 127,374 (0%) | 0% | 0 | Common Stock | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 40.59 per share. | 03 Feb 2023 | 2,079 | 75,496 (0%) | 0% | 40.6 | 84,392 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 4,140 | 77,575 (0%) | 0% | 0 | Common Stock | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 40.86 per share. | 03 Feb 2023 | 1,920 | 41,581 (0%) | 0% | 40.9 | 78,460 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 3,822 | 43,501 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 3,715 | 33,756 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 40.79 per share. | 03 Feb 2023 | 1,815 | 31,941 (0%) | 0% | 40.8 | 74,031 | Common Stock |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Sale of securities on an exchange or to another person at price $ 40.66 per share. | 03 Feb 2023 | 1,451 | 21,227 (0%) | 0% | 40.7 | 58,997 | Common Stock |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 4,140 | 22,678 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 40.67 per share. | 03 Feb 2023 | 1,413 | 24,946 (0%) | 0% | 40.7 | 57,464 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2023 | 4,033 | 26,359 (0%) | 0% | 0 | Common Stock | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 39.71 per share. | 30 Jan 2023 | 4,500 | 39,679 (0%) | 0% | 39.7 | 178,700 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 39.42 per share. | 30 Jan 2023 | 4,500 | 44,179 (0%) | 0% | 39.4 | 177,372 | Common Stock |
| Joseph Klein | Director | Sale of securities on an exchange or to another person at price $ 40.00 per share. | 17 Jan 2023 | 2,000 | 16,791 (0%) | 0% | 40 | 80,000 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 21,983 | 78,356 (0%) | 0% | 0 | Common Stock | |
| Richard S. Geary | EVP, Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 21,983 | 46,077 | - | - | Restricted Stock Unit | |
| Richard S. Geary | EVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 39.57 per share. | 17 Jan 2023 | 7,873 | 70,483 (0%) | 0% | 39.6 | 311,525 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 19,417 | 21,414 | - | - | Restricted Stock Unit | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 19,417 | 74,833 (0%) | 0% | 0 | Common Stock | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 38.89 per share. | 17 Jan 2023 | 6,978 | 67,855 (0%) | 0% | 38.9 | 271,356 | Common Stock |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 57,267 | 145,929 (0%) | 0% | 0 | Common Stock | |
| Brett P. Monia | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 57,267 | 176,861 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 39.49 per share. | 17 Jan 2023 | 25,066 | 120,863 (0%) | 0% | 39.5 | 989,947 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Sale of securities on an exchange or to another person at price $ 39.70 per share. | 17 Jan 2023 | 8,280 | 73,435 (0%) | 0% | 39.7 | 328,721 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 23,154 | 52,143 | - | - | Restricted Stock Unit | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 23,154 | 81,715 (0%) | 0% | 0 | Common Stock | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Sale of securities on an exchange or to another person at price $ 39.49 per share. | 17 Jan 2023 | 7,836 | 48,679 (0%) | 0% | 39.5 | 309,480 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 21,871 | 47,655 | - | - | Restricted Stock Unit | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 21,871 | 56,515 (0%) | 0% | 0 | Common Stock | |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 15,780 | 43,397 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 39.74 per share. | 17 Jan 2023 | 5,631 | 30,041 (0%) | 0% | 39.7 | 223,800 | Common Stock |
| Eric E. Swayze | EVP Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 15,780 | 35,672 (0%) | 0% | 0 | Common Stock | |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 10,197 | 22,286 (0%) | 0% | 0 | Common Stock | |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Sale of securities on an exchange or to another person at price $ 39.55 per share. | 17 Jan 2023 | 3,748 | 18,538 (0%) | 0% | 39.5 | 148,223 | Common Stock |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 10,197 | 55,326 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 904 | 1,226 (0%) | 0% | 0 | Common Stock | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 39.79 per share. | 17 Jan 2023 | 375 | 851 (0%) | 0% | 39.8 | 14,920 | Common Stock |
| Joseph T. Baroldi | EVP, Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 904 | 3,962 | - | - | Restricted Stock Unit | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 13,046 | 27,078 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 13,046 | 40,070 | - | - | Restricted Stock Unit | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale of securities on an exchange or to another person at price $ 39.57 per share. | 17 Jan 2023 | 4,752 | 22,326 (0%) | 0% | 39.6 | 188,052 | Common Stock |
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 17,207 | 68,060 | - | - | Restricted Stock Unit | |
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 14,338 | 25,801 | - | - | Performance Restricted Stock Units | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 16,387 | 40,831 | - | - | Restricted Stock Unit | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 13,656 | 24,482 | - | - | Performance Restricted Stock Units | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 89,005 | 234,128 | - | - | Restricted Stock Unit | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 146,128 | 316,701 | - | - | Performance Restricted Stock Units | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 19,460 | 75,297 | - | - | Restricted Stock Unit | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 16,216 | 28,635 | - | - | Performance Restricted Stock Units | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 17,207 | 69,526 | - | - | Restricted Stock Unit | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 14,338 | 25,801 | - | - | Performance Restricted Stock Units | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 14,338 | 25,482 | - | - | Performance Restricted Stock Units | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 17,207 | 59,177 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 81 | 581 | - | - | Restricted Stock Unit | |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 16,216 | 28,635 | - | - | Performance Restricted Stock Units | |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 19,460 | 65,523 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 1,800 | 4,866 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 14,749 | 58,099 | - | - | Restricted Stock Unit | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 12,290 | 12,290 | - | - | Performance Restricted Stock Units | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 14,338 | 26,437 | - | - | Performance Restricted Stock Units | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2023 | 17,207 | 53,116 | - | - | Restricted Stock Unit | |
| Richard S. Geary | EVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 22,942 | 22,942 | - | - | Non-Qualified Stock Option (right to buy) | |
| C. Frank Bennett | EVP, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 21,849 | 21,849 | - | - | Non-Qualified Stock Option (right to buy) | |
| Brett P. Monia | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 118,673 | 118,673 | - | - | Non-Qualified Stock Option (right to buy) | |
| Elizabeth L. Hougen | EVP, Finance & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 25,946 | 25,946 | - | - | Non-Qualified Stock Option (right to buy) | |
| Patrick R. O'Neil | EVP CLO & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 22,942 | 22,942 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 22,942 | 22,942 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 108 | 108 | - | - | Non-Qualified Stock Option (right to buy) | |
| Onaiza Cadoret-Manier | EVP, Chf GL Pdt Str & Oper Ofc | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 25,946 | 25,946 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 2,400 | 2,400 | - | - | Non-Qualified Stock Option (right to buy) | |
| Joseph T. Baroldi | EVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 19,665 | 19,665 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jan 2023 | 22,942 | 22,942 | - | - | Non-Qualified Stock Option (right to buy) | |
| Michael Hayden | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Oct 2022 | 1,777 | 23,109 (0%) | 0% | 0 | Common Stock | |
| Michael Hayden | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Oct 2022 | 1,777 | 7,110 | - | - | Restricted Stock Unit | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Payment of exercise price or tax liability using portion of securities received from the company at price $ 46.52 per share. | 17 Oct 2022 | 144 | 14,032 (0%) | 0% | 46.5 | 6,699 | Common Stock |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Oct 2022 | 416 | 14,176 (0%) | 0% | 0 | Common Stock | |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Oct 2022 | 416 | 35,909 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2022 | 500 | 500 | - | - | Restricted Stock Unit | |
| Eric E. Swayze | EVP Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Sep 2022 | 1,000 | 1,000 | - | - | Non-Qualified Stock Option (right to buy) | |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 44.55 per share. | 08 Sep 2022 | 460 | 19,892 (0%) | 0% | 44.6 | 20,493 | Common Stock |
| C. Frank Bennett | EVP, Chief Scientific Officer | Other type of transaction at price $ 28.97 per share. | 31 Aug 2022 | 183 | 55,416 (0%) | 0% | 29.0 | 5,301 | Common Stock |
| Elizabeth L. Hougen | EVP, Finance & CFO | Other type of transaction at price $ 28.97 per share. | 31 Aug 2022 | 202 | 58,561 (0%) | 0% | 29.0 | 5,852 | Common Stock |
| Patrick R. O'Neil | EVP CLO & General Counsel | Other type of transaction at price $ 28.97 per share. | 31 Aug 2022 | 108 | 34,644 (0%) | 0% | 29.0 | 3,129 | Common Stock |
| Eric E. Swayze | EVP Research | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 05 Aug 2022 | 1 | 20,352 (0%) | 0% | 45 | 45 | Common Stock |