17.21 -0.08 (-0.46%)
538.1K XNAS Volume
XNAS 20 Mar, 2025 4:00 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.07 per share. | 20 Feb 2025 | 2,565 | 42,374 (0%) | 0% | 18.1 | 46,350 | Common Stock |
| Stephen Basso | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Feb 2025 | 843 | 12,939 (0%) | 0% | 0 | Common Stock | |
| Stephen Basso | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.07 per share. | 20 Feb 2025 | 1,106 | 11,833 (0%) | 0% | 18.1 | 19,985 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Nov 2024 | 300 | 45,915 (0%) | 0% | 0 | Common Stock | |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.15 per share. | 20 Nov 2024 | 976 | 44,939 (0%) | 0% | 19.1 | 18,690 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.49 per share. | 20 Aug 2024 | 975 | 45,615 (0%) | 0% | 18.5 | 18,028 | Common Stock |
| Jules Haimovitz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 10,000 | 30,000 | - | - | Non-statutory Stock Option | |
| Jules Haimovitz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 13,923 | 130,829 (0%) | 0% | 0 | Common Stock | |
| Odysseas D. Kostas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 10,000 | 30,000 | - | - | Non-statutory Stock Option | |
| Odysseas D. Kostas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 13,923 | 122,625 (0%) | 0% | 0 | Common Stock | |
| Sapna Srivastava | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 13,923 | 44,096 (0%) | 0% | 0 | Common Stock | |
| Sapna Srivastava | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 10,000 | 22,500 | - | - | Non-statutory Stock Option | |
| Sarah J. Schlesinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 10,000 | 30,000 | - | - | Non-statutory Stock Option | |
| Sarah J. Schlesinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 13,923 | 118,629 (0%) | 0% | 0 | Common Stock | |
| Derek A. Small | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 13,923 | 23,172 (0%) | 0% | 0 | Common Stock | |
| Derek A. Small | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 10,000 | 10,833 | - | - | Non-statutory Stock Option | |
| Mark DiPaolo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 10,000 | 30,000 | - | - | Non-statutory Stock Option | |
| Mark DiPaolo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 13,923 | 118,629 (0%) | 0% | 0 | Common Stock | |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 16.13 per share. | 20 May 2024 | 976 | 46,590 (0%) | 0% | 16.1 | 15,743 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 23,022 | 63,022 | - | - | Non-statutory Stock Option | |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 14.88 per share. | 05 Mar 2024 | 10,752 | 47,566 (0%) | 0% | 14.9 | 159,990 | Common Stock |
| Pavel Raifeld | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 75,000 | 575,000 | - | - | Non-statutory Stock Option | |
| Pavel Raifeld | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 100,000 | 675,000 | - | - | Non-statutory Stock Option | |
| Pavel Raifeld | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 150,000 | 825,000 | - | - | Non-statutory Stock Option | |
| Stephen Basso | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2024 | 25,899 | 175,899 | - | - | Non-statutory Stock Option | |
| Stephen Basso | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 14.88 per share. | 05 Mar 2024 | 12,096 | 12,096 (0%) | 0% | 14.9 | 179,988 | Common Stock |
| Zhen Marianne | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 15.80 per share. | 20 Feb 2024 | 2,862 | 36,814 (0%) | 0% | 15.8 | 45,220 | Common Stock |
| Stephen Basso | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Aug 2023 | 150,000 | 150,000 | - | - | Nonqualified Stock Option | |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 13.64 per share. | 18 Aug 2023 | 785 | 51,152 (0%) | 0% | 13.6 | 10,707 | Common Stock |
| Jules Haimovitz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 10,000 | 20,000 | - | - | Non-statutory Stock Option | |
| Jules Haimovitz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 16,495 | 116,906 (0%) | 0% | 0 | Common Stock | |
| Odysseas D. Kostas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 16,495 | 108,702 (0%) | 0% | 0 | Common Stock | |
| Odysseas D. Kostas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 10,000 | 20,000 | - | - | Non-statutory Stock Option | |
| Sapna Srivastava | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 10,000 | 12,500 | - | - | Non-statutory Stock Option | |
| Sapna Srivastava | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 16,495 | 30,173 (0%) | 0% | 0 | Common Stock | |
| Sarah J. Schlesinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 10,000 | 20,000 | - | - | Non-statutory Stock Option | |
| Sarah J. Schlesinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 16,495 | 104,706 (0%) | 0% | 0 | Common Stock | |
| Mark DiPaolo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 16,495 | 104,706 (0%) | 0% | 0 | Common Stock | |
| Mark DiPaolo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 10,000 | 20,000 | - | - | Non-statutory Stock Option | |
| Deborah L. Birx | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 10,000 | 20,000 | - | - | Non-statutory Stock Option | |
| Deborah L. Birx | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2023 | 16,495 | 58,984 (0%) | 0% | 0 | Common Stock | |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 13.47 per share. | 19 May 2023 | 784 | 51,937 (0%) | 0% | 13.5 | 10,560 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2023 | 1,576 | 52,721 (0%) | 0% | 0 | Common Stock | |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Apr 2023 | 20,000 | 40,000 | - | - | Non-statutory Stock Option | |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Apr 2023 | 14,344 | 51,145 (0%) | 0% | 0 | Common Stock | |
| Pavel Raifeld | Chief Executive Officer | Purchase of securities on an exchange or from another person at price $ 10.87 per share. | 10 Mar 2023 | 3,000 | 9,799 (0%) | 0% | 10.9 | 32,603 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.42 per share. | 17 Feb 2023 | 1,852 | 36,801 (0%) | 0% | 12.4 | 23,002 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Nov 2022 | 433 | 39,481 (0%) | 0% | 0 | Common Stock | |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 13.55 per share. | 18 Nov 2022 | 828 | 38,653 (0%) | 0% | 13.5 | 11,219 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.12 per share. | 19 Aug 2022 | 830 | 39,048 (0%) | 0% | 14.1 | 11,720 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 16.29 per share. | 20 May 2022 | 828 | 39,878 (0%) | 0% | 16.3 | 13,488 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2022 | 1,834 | 40,706 (0%) | 0% | 0 | Common Stock | |
| Pavel Raifeld | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Apr 2022 | 150,000 | 500,000 | - | - | Nonstatutory Stock Option | |
| George W. Bickerstaff | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 10,000 | 10,000 | - | - | Non-statutory Stock Option | |
| George W. Bickerstaff | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 12,647 | 137,207 (0%) | 0% | 0 | Common Stock | |
| Jules Haimovitz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 12,647 | 100,411 (0%) | 0% | 0 | Common Stock | |
| Jules Haimovitz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 10,000 | 10,000 | - | - | Non-statutory Stock Option | |
| Odysseas D. Kostas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 12,647 | 92,207 (0%) | 0% | 0 | Common Stock | |
| Odysseas D. Kostas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 10,000 | 0 | - | - | Non-statutory Stock Option | |
| Sarah J. Schlesinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 10,000 | 10,000 | - | - | Non-statutory Stock Option | |
| Sarah J. Schlesinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 12,647 | 88,211 (0%) | 0% | 0 | Common Stock | |
| Mark DiPaolo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 10,000 | 10,000 | - | - | Non-statutory Stock Option | |
| Mark DiPaolo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 12,647 | 88,211 (0%) | 0% | 0 | Common Stock | |
| Deborah L. Birx | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 10,000 | 10,000 | - | - | Non-statutory Stock Option | |
| Deborah L. Birx | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Apr 2022 | 12,647 | 42,489 (0%) | 0% | 0 | Common Stock | |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 6,691 | 38,872 (0%) | 0% | 0 | Common Stock | |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 15,000 | 20,000 | - | - | Non-statutory Stock Option | |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.99 per share. | 18 Feb 2022 | 2,277 | 32,181 (0%) | 0% | 20.0 | 45,517 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.05 per share. | 19 Nov 2021 | 758 | 34,458 (0%) | 0% | 17.1 | 12,924 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 15.89 per share. | 19 Aug 2021 | 1,129 | 35,364 (0%) | 0% | 15.9 | 17,940 | Common Stock |
| George W. Bickerstaff | Director | Purchase of securities on an exchange or from another person at price $ 13.46 per share. | 21 May 2021 | 10,000 | 124,560 (0%) | 0% | 13.5 | 134,619 | Common Stock |
| George W. Bickerstaff | Director | Purchase of securities on an exchange or from another person at price $ 12.97 per share. | 21 May 2021 | 10,000 | 114,560 (0%) | 0% | 13.0 | 129,670 | Common Stock |
| Pavel Raifeld | Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2021 | 100,000 | 350,000 | - | - | Nonstatutory Stock Option | |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 13.32 per share. | 20 May 2021 | 759 | 39,295 (0%) | 0% | 13.3 | 10,110 | Common Stock |
| George W. Bickerstaff | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2021 | 17,482 | 104,560 (0%) | 0% | 0 | Common Stock | |
| Jules Haimovitz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2021 | 17,482 | 87,764 (0%) | 0% | 0 | Common Stock | |
| Odysseas D. Kostas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2021 | 17,482 | 79,560 (0%) | 0% | 0 | Common Stock | |
| Sarah J. Schlesinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2021 | 17,482 | 75,564 (0%) | 0% | 0 | Common Stock | |
| Mark DiPaolo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2021 | 17,482 | 75,564 (0%) | 0% | 0 | Common Stock | |
| Deborah L. Birx | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2021 | 17,482 | 29,842 (0%) | 0% | 0 | Common Stock | |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2021 | 5,000 | 5,000 | - | - | Non-statutory Stock Option | |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2021 | 10,305 | 38,399 (0%) | 0% | 0 | Common Stock | |
| Deborah L. Birx | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Mar 2021 | 1,612 | 12,360 (0%) | 0% | 0 | Common Stock | |
| Deborah L. Birx | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Mar 2021 | 10,748 | 10,748 | - | - | Restricted Stock Units | |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.74 per share. | 19 Feb 2021 | 2,108 | 28,094 (0%) | 0% | 11.7 | 24,748 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 10.95 per share. | 20 Nov 2020 | 798 | 30,202 (0%) | 0% | 10.9 | 8,738 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 13.19 per share. | 20 Aug 2020 | 797 | 30,243 (0%) | 0% | 13.2 | 10,512 | Common Stock |
| Geoffrey L. Hulme | Interim Principal Exec Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.10 per share. | 20 May 2020 | 339 | 46,251 (0%) | 0% | 14.1 | 4,780 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.10 per share. | 20 May 2020 | 866 | 31,040 (0%) | 0% | 14.1 | 12,211 | Common Stock |
| George W. Bickerstaff | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2020 | 16,917 | 87,078 (0%) | 0% | 0 | Common Stock | |
| Jules Haimovitz | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2020 | 16,917 | 70,282 (0%) | 0% | 0 | Common Stock | |
| Odysseas D. Kostas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2020 | 16,917 | 62,078 (0%) | 0% | 0 | Common Stock | |
| Sarah J. Schlesinger | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2020 | 16,917 | 58,082 (0%) | 0% | 0 | Common Stock | |
| Mark DiPaolo | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2020 | 16,917 | 58,082 (0%) | 0% | 0 | Common Stock | |
| Geoffrey L. Hulme | Interim Principal Exec Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 15,734 | 45,469 (0%) | 0% | 0 | Common Stock | |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2020 | 8,741 | 30,654 (0%) | 0% | 0 | Common Stock | |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.59 per share. | 20 Nov 2019 | 602 | 26,940 (0%) | 0% | 12.6 | 7,579 | Common Stock |
| Geoffrey L. Hulme | Interim PEO | Grant, award, or other acquisition of securities at price $ 10.89 per share. | 04 Sep 2019 | 3,000 | 31,000 (0%) | 0% | 10.9 | 32,684 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.50 per share. | 20 Aug 2019 | 600 | 27,542 (0%) | 0% | 11.5 | 6,900 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.21 per share. | 20 May 2019 | 601 | 28,142 (0%) | 0% | 14.2 | 8,540 | Common Stock |
| George W. Bickerstaff | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2019 | 16,399 | 70,161 (0%) | 0% | 0 | Common Stock | |
| Jules Haimovitz | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2019 | 16,399 | 53,365 (0%) | 0% | 0 | Common Stock | |
| Odysseas D. Kostas | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2019 | 16,399 | 45,161 (0%) | 0% | 0 | Common Stock | |
| Sarah J. Schlesinger | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2019 | 16,399 | 41,165 (0%) | 0% | 0 | Common Stock | |
| Mark DiPaolo | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2019 | 16,399 | 41,165 (0%) | 0% | 0 | Common Stock | |
| Geoffrey L. Hulme | Interim PEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2019 | 14,677 | 27,584 (0%) | 0% | 0 | Common Stock | |
| Marianne Zhen | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2019 | 8,154 | 26,818 (0%) | 0% | 0 | Common Stock | |
| George W. Bickerstaff | None | Purchase of securities on an exchange or from another person at price $ 14.90 per share. | 21 Feb 2019 | 10,000 | 38,762 (0%) | 0% | 14.9 | 148,958 | Common Stock |
| Marianne Zhen | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.67 per share. | 20 Feb 2019 | 1,353 | 24,281 (0%) | 0% | 14.7 | 19,849 | Common Stock |
| Geoffrey L. Hulme | Interim PEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 14.53 per share. | 19 Feb 2019 | 3,093 | 12,907 (0%) | 0% | 14.5 | 44,941 | Common Stock |
| George W. Bickerstaff | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Dec 2017 | 14,513 | 14,513 (0%) | 0% | 0 | Common Stock | |
| Odysseas D. Kostas | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Dec 2017 | 14,513 | 14,513 (0%) | 0% | 0 | Common Stock | |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Sale of securities on an exchange or to another person at price $ 13.13 per share. | 04 Dec 2017 | 12,022 | 980,907 (0%) | 0% | 13.1 | 157,791 | Common Stock |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 13.17 per share. | 20 Nov 2017 | 43,038 | 992,929 (0%) | 0% | 13.2 | 566,810 | Common Stock |
| Michael Conner | Sr VP & Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 13.17 per share. | 20 Nov 2017 | 4,470 | 279,422 (0%) | 0% | 13.2 | 58,870 | Common Stock |
| George B. Abercrombie | Sr. VP & Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 13.17 per share. | 20 Nov 2017 | 3,358 | 263,866 (0%) | 0% | 13.2 | 44,225 | Common Stock |
| George B. Abercrombie | Sr. VP & Chief Comm. Officer | Sale of securities on an exchange or to another person at price $ 13.26 per share. | 20 Nov 2017 | 5,215 | 258,651 (0%) | 0% | 13.3 | 69,145 | Common Stock |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 13.17 per share. | 20 Nov 2017 | 14,757 | 226,800 (0%) | 0% | 13.2 | 194,350 | Common Stock |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Sale of securities on an exchange or to another person at price $ 13.29 per share. | 20 Nov 2017 | 13,000 | 213,800 (0%) | 0% | 13.3 | 172,795 | Common Stock |
| Eric d'Esparbes | SVP and CFO | Sale of securities on an exchange or to another person at price $ 13.04 per share. | 20 Nov 2017 | 1,825 | 335,202 (0%) | 0% | 13.0 | 23,798 | Common Stock |
| Eric d'Esparbes | SVP and CFO | Sale of securities on an exchange or to another person at price $ 13.31 per share. | 20 Nov 2017 | 13,460 | 321,742 (0%) | 0% | 13.3 | 179,171 | Common Stock |
| Eric d'Esparbes | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 13.17 per share. | 20 Nov 2017 | 6,141 | 337,027 (0%) | 0% | 13.2 | 80,877 | Common Stock |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.28 per share. | 20 Aug 2017 | 12,917 | 1,035,967 (0%) | 0% | 12.3 | 158,621 | Common Stock |
| Michael Conner | Sr VP & Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.28 per share. | 20 Aug 2017 | 3,179 | 283,892 (0%) | 0% | 12.3 | 39,038 | Common Stock |
| George B. Abercrombie | Sr. VP & Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.28 per share. | 20 Aug 2017 | 2,886 | 267,224 (0%) | 0% | 12.3 | 35,440 | Common Stock |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.28 per share. | 20 Aug 2017 | 2,596 | 241,557 (0%) | 0% | 12.3 | 31,879 | Common Stock |
| Eric d'Esparbes | SVP and CFO | Sale of securities on an exchange or to another person at price $ 12.20 per share. | 20 Aug 2017 | 1,825 | 343,168 (0%) | 0% | 12.2 | 22,265 | Common Stock |
| Eric d'Esparbes | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.28 per share. | 20 Aug 2017 | 5,770 | 344,993 (0%) | 0% | 12.3 | 70,856 | Common Stock |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.86 per share. | 20 May 2017 | 12,897 | 1,048,884 (0%) | 0% | 11.9 | 152,958 | Common Stock |
| Michael Conner | Sr VP & Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.86 per share. | 20 May 2017 | 3,176 | 287,071 (0%) | 0% | 11.9 | 37,667 | Common Stock |
| George B. Abercrombie | Sr. VP & Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.86 per share. | 20 May 2017 | 2,228 | 270,110 (0%) | 0% | 11.9 | 26,424 | Common Stock |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Sale of securities on an exchange or to another person at price $ 12.01 per share. | 20 May 2017 | 7,815 | 244,153 (0%) | 0% | 12.0 | 93,858 | Common Stock |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.86 per share. | 20 May 2017 | 2,590 | 251,968 (0%) | 0% | 11.9 | 30,717 | Common Stock |
| Eric d'Esparbes | SVP and CFO | Sale of securities on an exchange or to another person at price $ 11.85 per share. | 20 May 2017 | 1,825 | 350,763 (0%) | 0% | 11.8 | 21,626 | Common Stock |
| Eric d'Esparbes | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.86 per share. | 20 May 2017 | 4,208 | 352,588 (0%) | 0% | 11.9 | 49,907 | Common Stock |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2017 | 19,857 | 73,805 (0%) | 0% | 0 | Common Stock | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2017 | 19,857 | 70,554 (0%) | 0% | 0 | Common Stock | |
| Patrick G. LePore | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2017 | 19,857 | 58,278 (0%) | 0% | 0 | Common Stock | |
| William H. Waltrip | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2017 | 19,857 | 161,789 (0%) | 0% | 0 | Common Stock | |
| Barbara G. Duncan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2017 | 19,857 | 52,318 (0%) | 0% | 0 | Common Stock | |
| Paul A. Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Apr 2017 | 19,857 | 73,805 (0%) | 0% | 0 | Common Stock | |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.04 per share. | 20 Feb 2017 | 19,429 | 1,059,281 (0%) | 0% | 12.0 | 233,925 | Common Stock |
| Michael Conner | Sr VP & Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.04 per share. | 20 Feb 2017 | 5,860 | 287,747 (0%) | 0% | 12.0 | 70,554 | Common Stock |
| George B. Abercrombie | Sr. VP & Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.04 per share. | 20 Feb 2017 | 5,355 | 269,838 (0%) | 0% | 12.0 | 64,474 | Common Stock |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.04 per share. | 20 Feb 2017 | 6,367 | 253,782 (0%) | 0% | 12.0 | 76,659 | Common Stock |
| Eric d'Esparbes | SVP and CFO | Sale of securities on an exchange or to another person at price $ 12.07 per share. | 20 Feb 2017 | 1,825 | 354,296 (0%) | 0% | 12.1 | 22,028 | Common Stock |
| Eric d'Esparbes | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 12.04 per share. | 20 Feb 2017 | 8,604 | 356,121 (0%) | 0% | 12.0 | 103,592 | Common Stock |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2017 | 333,495 | 1,078,710 (0%) | 0% | 0 | Common Stock | |
| Michael Conner | Sr VP & Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2017 | 133,398 | 293,607 (0%) | 0% | 0 | Common Stock | |
| George B. Abercrombie | Sr. VP & Chief Comm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2017 | 106,718 | 275,193 (0%) | 0% | 0 | Common Stock | |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2017 | 106,718 | 260,149 (0%) | 0% | 0 | Common Stock | |
| Eric d'Esparbes | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jan 2017 | 133,398 | 364,725 (0%) | 0% | 0 | Common Stock | |
| Michael Conner | Sr VP & Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2016 | 2,893 | 160,209 | - | - | Common Stock | |
| George B. Abercrombie | Sr. VP & Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2016 | 1,273 | 168,475 | - | - | Common Stock | |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2016 | 1,487 | 157,131 | - | - | Common Stock | |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Nov 2016 | 3,700 | 153,431 | - | - | Common Stock | |
| Eric d'Esparbes | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2016 | 3,832 | 233,127 | - | - | Common Stock | |
| Eric d'Esparbes | SVP and CFO | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Nov 2016 | 1,800 | 231,327 | - | - | Common Stock | |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 18 Nov 2016 | 8,417 | 745,215 | - | - | Common Stock | |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Nov 2016 | 63,135 | 753,347 | - | - | Common Stock | |
| Barbara G. Duncan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Nov 2016 | 32,461 | 32,461 | - | - | Common Stock | |
| Patrick G. Lepore | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Oct 2016 | 38,421 | 38,421 | - | - | Common Stock | |
| Michael Conner | Sr VP & Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2016 | 9,544 | 162,870 | - | - | Common Stock | |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2016 | 8,467 | 690,212 | - | - | Common Stock | |
| George B. Abercrombie | Sr. VP & Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2016 | 1,939 | 169,463 | - | - | Common Stock | |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2016 | 1,501 | 157,917 | - | - | Common Stock | |
| Eric d'Esparbes | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2016 | 2,845 | 239,893 | - | - | Common Stock | |
| Eric d'Esparbes | SVP and CFO | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Aug 2016 | 3,700 | 236,193 | - | - | Common Stock | |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2016 | 8,428 | 698,679 | - | - | Common Stock | |
| George B. Abercrombie | Sr. VP & Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2016 | 1,276 | 171,402 | - | - | Common Stock | |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2016 | 1,490 | 159,418 | - | - | Common Stock | |
| Eric d'Esparbes | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2016 | 2,818 | 242,738 | - | - | Common Stock | |
| James L. Tyree | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 18 May 2016 | 813 | 50,697 | - | - | Common Stock | |
| William H. Waltrip | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2016 | 18,328 | 141,932 | - | - | Common Stock | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2016 | 18,328 | 53,948 | - | - | Common Stock | |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2016 | 18,328 | 53,948 | - | - | Common Stock | |
| Paul Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2016 | 18,328 | 53,948 | - | - | Common Stock | |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 19 Feb 2016 | 18,659 | 704,607 | - | - | Common Stock | |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 19 Feb 2016 | 6,486 | 159,068 | - | - | Common Stock | |
| Eric d'Esparbes | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 19 Feb 2016 | 5,457 | 243,056 | - | - | Common Stock | |
| Michael Conner | Sr VP & Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jan 2016 | 67,126 | 172,414 | - | - | Common Stock | |
| Michael W. Aguiar | Director, President & Chief Exec Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jan 2016 | 289,334 | 723,266 | - | - | Common Stock | |
| George B. Abercrombie | Sr. VP & Chief Comm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jan 2016 | 92,587 | 175,554 | - | - | Common Stock | |
| Theodore L. Witek | Sr. VP & Chief Scientific Off. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jan 2016 | 92,587 | 165,554 | - | - | Common Stock | |
| Eric d'Esparbes | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jan 2016 | 115,734 | 248,513 | - | - | Common Stock | |
| Eric d'Esparbes | SVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2015 | 7,940 | 132,779 | - | - | Common Stock | |
| Michael Conner | Sr VP & Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jul 2015 | 105,288 | 105,288 | - | - | Common Stock | |
| Michael W. Aguiar | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 02 Jun 2015 | 24,698 | 432,653 | - | - | Common Stock | |
| James L. Tyree | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Jun 2015 | 2,438 | 33,182 | - | - | Common Stock | |
| William H. Waltrip | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 27 May 2015 | 16,313 | 123,604 | - | - | Common Stock | |
| William H. Waltrip | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 May 2015 | 16,313 | 0 | - | - | Stock Option (Right to Buy) | |
| William H. Waltrip | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 May 2015 | 16,313 | 139,917 | - | - | Common Stock | |
| Michael W. Aguiar | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2015 | 3,256 | 457,351 | - | - | Common Stock | |
| William H. Waltrip | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2015 | 13,950 | 123,604 | - | - | Common Stock | |
| Terrence C. Kearney | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2015 | 13,950 | 37,083 | - | - | Common Stock | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2015 | 13,950 | 35,620 | - | - | Common Stock | |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2015 | 13,950 | 35,620 | - | - | Common Stock | |
| Paul Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2015 | 13,950 | 35,620 | - | - | Common Stock | |
| Michael W. Aguiar | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2015 | 6,789 | 458,107 | - | - | Common Stock | |
| Michael W. Aguiar | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2015 | 176,056 | 464,896 | - | - | Common Stock | |
| George B. Abercrombie | Sr. VP, Corp. Partnerships | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2015 | 71,429 | 81,429 | - | - | Common Stock | |
| Theodore L. Witek | Sr. VP, Corp Partnerships | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2015 | 71,429 | 71,429 | - | - | Common Stock | |
| Eric d'Esparbes | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jan 2015 | 36,972 | 139,443 | - | - | Common Stock | |
| William H. Waltrip | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2014 | 3,250 | 103,314 | - | - | Common Stock | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2014 | 6,500 | 21,670 | - | - | Common Stock | |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2014 | 6,500 | 21,670 | - | - | Common Stock | |
| Paul Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Dec 2014 | 6,500 | 21,670 | - | - | Common Stock | |
| Terrence C. Kearney | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Oct 2014 | 23,133 | 23,133 | - | - | Common Stock | |
| Eric d'Esparbes | SVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2014 | 102,471 | 102,471 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2014 | 3,261 | 443,013 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2014 | 3,261 | 401,538 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2014 | 3,261 | 334,040 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2014 | 3,261 | 262,198 | - | - | Common Stock | |
| Rick E. Winningham | None | Sale or transfer of securities back to the company at price $ 0.00 per share. | 15 Aug 2014 | 96,250 | 825,391 | - | - | Common Stock | |
| Michael W. Aguiar | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2014 | 43,905 | 288,840 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2014 | 13,882 | 0 | - | - | Stock Option (Right to Buy) | |
| Junning Lee | Sr. VP, Technical Operations | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 13 Aug 2014 | 53,424 | 265,459 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2014 | 23,705 | 318,883 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2014 | 24,338 | 0 | - | - | Stock Option (Right to Buy) | |
| Junning Lee | Sr. VP, Technical Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2014 | 23,705 | 0 | - | - | Stock Option (Right to Buy) | |
| Junning Lee | Sr. VP, Technical Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2014 | 24,338 | 295,178 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2014 | 12,516 | 270,840 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2014 | 13,882 | 258,324 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Aug 2014 | 12,516 | 0 | - | - | Stock Option (Right to Buy) | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 11 Aug 2014 | 27,108 | 447,322 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 11 Aug 2014 | 1,048 | 446,274 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Aug 2014 | 33,667 | 0 | - | - | Stock Option (Right to Buy) | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Aug 2014 | 33,667 | 474,430 | - | - | Common Stock | |
| Theodore L. Witek | Sr. VP, Corp Partnerships | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2014 | 125,000 | 125,000 | - | - | Stock Option Grant (Right to Buy) | |
| George B. Abercrombie | Sr. VP, Corp. Partnerships | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 10,000 | 10,000 | - | - | Common Stock | |
| George B. Abercrombie | Sr. VP, Corp. Partnerships | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2014 | 100,000 | 100,000 | - | - | Stock Option Grant (Right to Buy) | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2014 | 62,403 | 921,641 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2014 | 28,365 | 440,763 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2014 | 28,365 | 244,935 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2014 | 28,365 | 404,799 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2014 | 28,365 | 337,301 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2014 | 19,855 | 244,442 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 46,200 | 859,238 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 110,000 | 813,038 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 50,000 | 391,398 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 21,000 | 412,398 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 21,000 | 216,570 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 50,000 | 195,570 | - | - | Common Stock | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 15,170 | - | - | Common Stock | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 7,585 | - | - | Common Stock | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 7,585 | - | - | Stock Option (Right to Buy) | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 7,585 | - | - | Stock Option (Right to Buy) | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 6,000 | - | - | Common Stock | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 12,000 | - | - | Common Stock | |
| James L. Tyree | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 7,585 | - | - | Stock Option (Right to Buy) | |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 7,585 | - | - | Common Stock | |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 15,170 | - | - | Common Stock | |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 6,000 | - | - | Common Stock | |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 12,000 | - | - | Common Stock | |
| Catherine J. Friedman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 7,585 | - | - | Stock Option (Right to Buy) | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 21,000 | 376,434 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 50,000 | 355,434 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 21,000 | 308,936 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 50,000 | 287,936 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 50,000 | 209,887 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 14,700 | 224,587 | - | - | Common Stock | |
| Paul Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Paul Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Paul Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 15,170 | - | - | Common Stock | |
| Paul Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 12,000 | - | - | Common Stock | |
| Paul Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 7,585 | - | - | Stock Option (Right to Buy) | |
| Paul Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 7,585 | - | - | Common Stock | |
| Paul Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 6,000 | 6,000 | - | - | Common Stock | |
| Paul Pepe | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2014 | 7,585 | 7,585 | - | - | Stock Option (Right to Buy) | |
| George M. Whitesides | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 606,377 | - | - | Common Stock | |
| George M. Whitesides | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| William H. Waltrip | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 100,064 | - | - | Common Stock | |
| William H. Waltrip | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Peter S. Ringrose | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 36,000 | - | - | Common Stock | |
| Peter S. Ringrose | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| William D. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| William D. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 83,935 | - | - | Common Stock | |
| Burton G. Malkiel | None | Gift of securities by or to the insider at price $ 0.00 per share. | 22 May 2014 | 1,000 | 40,000 | - | - | Common Stock | |
| Burton G. Malkiel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Burton G. Malkiel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 41,000 | - | - | Common Stock | |
| Robert V. Gunderson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 115,970 | - | - | Common Stock | |
| Robert V. Gunderson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Henrietta Fore | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 33,000 | - | - | Common Stock | |
| Henrietta Fore | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2014 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 09 May 2014 | 50,225 | 703,038 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 09 May 2014 | 22,833 | 341,398 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 09 May 2014 | 21,405 | 145,570 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 09 May 2014 | 18,849 | 305,434 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Gift of securities by or to the insider at price $ 0.00 per share. | 09 May 2014 | 1,200 | 237,936 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 09 May 2014 | 22,833 | 239,136 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 09 May 2014 | 14,650 | 159,887 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2014 | 82,500 | 753,263 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2014 | 37,500 | 364,231 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2014 | 37,500 | 166,975 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2014 | 37,500 | 324,283 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2014 | 37,500 | 261,969 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Apr 2014 | 26,250 | 174,537 | - | - | Common Stock | |
| Robert V. Gunderson | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2014 | 25,806 | 0 | - | - | Stock Option (Right to Buy) | |
| Robert V. Gunderson | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2014 | 25,806 | 109,970 | - | - | Common Stock | |
| William D. Young | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Apr 2014 | 25,806 | 0 | - | - | Stock Option (Right to Buy) | |
| William D. Young | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Apr 2014 | 25,806 | 77,935 | - | - | Common Stock | |
| William H. Waltrip | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2014 | 25,806 | 0 | - | - | Stock Option (Right to Buy) | |
| William H. Waltrip | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2014 | 25,806 | 94,064 | - | - | Common Stock | |
| Arnold J. Levine | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2014 | 25,806 | 111,794 | - | - | Common Stock | |
| Arnold J. Levine | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2014 | 25,806 | 0 | - | - | Stock Option (Right to Buy) | |
| George M. Whitesides | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2014 | 25,806 | 0 | - | - | Stock Option (Right to Buy) | |
| George M. Whitesides | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2014 | 25,806 | 600,377 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2014 | 29,250 | 0 | - | - | Stock Option (Right to Buy) | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2014 | 29,250 | 224,469 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2014 | 12,903 | 195,219 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Mar 2014 | 12,903 | 0 | - | - | Stock Option (Right to Buy) | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 Mar 2014 | 64,006 | 328,531 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2014 | 30,967 | 0 | - | - | Stock Option (Right to Buy) | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2014 | 65,806 | 392,537 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2014 | 30,967 | 326,731 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 Mar 2014 | 1,800 | 326,731 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2014 | 65,806 | 0 | - | - | Stock Option (Right to Buy) | |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2014 | 9,297 | 670,763 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2014 | 4,310 | 295,764 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2014 | 4,302 | 129,475 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2014 | 4,311 | 286,783 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2014 | 4,307 | 182,316 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2014 | 3,854 | 148,287 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 14 Feb 2014 | 30,400 | 191,223 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 14 Feb 2014 | 4,600 | 186,623 | - | - | Common Stock | |
| Junning Lee | Sr. VP, Technical Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2014 | 11,000 | 152,141 | - | - | Common Stock | |
| Frank Pasqualone | Sr. Vice President, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2014 | 20,000 | 20,000 | - | - | Common Stock | |
| Frank Pasqualone | Sr. Vice President, Operations | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jan 2014 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Burton G. Malkiel | None | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2013 | 1,000 | 35,000 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2013 | 450 | 221,623 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2013 | 10,046 | 680,060 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2013 | 4,569 | 300,074 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2013 | 4,569 | 133,777 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2013 | 4,569 | 222,073 | - | - | Common Stock | |
| Jeffrey David Jonker | Senior VP, Corp. & Bus. Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Oct 2013 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Jeffrey David Jonker | Senior VP, Corp. & Bus. Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Oct 2013 | 15,000 | 15,000 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 12 Sep 2013 | 22,353 | 690,106 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2013 | 10,046 | 712,459 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2013 | 3,773 | 304,643 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2013 | 4,570 | 138,346 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2013 | 18,750 | 226,642 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2013 | 18,750 | 0 | - | - | Stock Option (Right to Buy) | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2013 | 3,813 | 207,892 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Jul 2013 | 7,000 | 211,705 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2013 | 11,000 | 722,505 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2013 | 5,000 | 308,416 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2013 | 5,000 | 142,916 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2013 | 5,000 | 291,094 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jul 2013 | 5,000 | 218,705 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 07 Jun 2013 | 31,038 | 303,416 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 29 May 2013 | 3,808 | 48,749 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2013 | 4,570 | 207,254 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2013 | 4,570 | 0 | - | - | Stock Option (Right to Buy) | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2013 | 6,451 | 0 | - | - | Stock Option (Right to Buy) | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2013 | 6,451 | 213,705 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2013 | 10,046 | 711,505 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2013 | 2,443 | 52,557 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2013 | 3,292 | 334,454 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2013 | 4,570 | 137,916 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2013 | 3,292 | 286,094 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2013 | 3,292 | 202,684 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 13 May 2013 | 16,129 | 55,000 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 May 2013 | 16,129 | 0 | - | - | Stock Option (Right to Buy) | |
| David L. Brinkley | Head of Business Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 May 2013 | 16,129 | 71,129 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2013 | 16,129 | 71,129 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2013 | 16,129 | 0 | - | - | Stock Option (Right to Buy) | |
| David L. Brinkley | Head of Business Dev. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 May 2013 | 16,129 | 55,000 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2013 | 385,161 | 0 | - | - | Stock Option (Right to Buy) | |
| Rick E. Winningham | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Apr 2013 | 253,955 | 723,128 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2013 | 385,161 | 977,083 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Apr 2013 | 1,577 | 721,551 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Apr 2013 | 17,004 | 55,100 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Apr 2013 | 100 | 55,000 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2013 | 8,333 | 72,104 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2013 | 8,333 | 0 | - | - | Stock Option (Right to Buy) | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Apr 2013 | 160,779 | 152,586 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Apr 2013 | 10,100 | 142,486 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2013 | 170,879 | 0 | - | - | Stock Option (Right to Buy) | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2013 | 170,879 | 313,365 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Apr 2013 | 6,800 | 206,176 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Apr 2013 | 200 | 205,976 | - | - | Common Stock | |
| George M. Whitesides | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 574,571 | - | - | Common Stock | |
| George M. Whitesides | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Arnold J. Levine | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 85,988 | - | - | Common Stock | |
| Arnold J. Levine | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| William H. Waltrip | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| William H. Waltrip | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 68,258 | - | - | Common Stock | |
| Peter S. Ringrose | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 30,000 | - | - | Common Stock | |
| Peter S. Ringrose | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| William D. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 52,129 | - | - | Common Stock | |
| William D. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Burton G. Malkiel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Burton G. Malkiel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 36,000 | - | - | Common Stock | |
| Robert V. Gunderson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Robert V. Gunderson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 84,164 | - | - | Common Stock | |
| Henrietta Fore | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 27,000 | - | - | Common Stock | |
| Henrietta Fore | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Apr 2013 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2013 | 10,655 | 591,922 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2013 | 3,416 | 63,771 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2013 | 5,004 | 337,746 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2013 | 5,002 | 219,976 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 20 Feb 2013 | 7,000 | 212,976 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2013 | 11,000 | 602,577 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2013 | 5,000 | 67,187 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2013 | 5,000 | 342,750 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2013 | 5,000 | 142,486 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2013 | 5,000 | 289,386 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2013 | 5,000 | 224,978 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jan 2013 | 2,655 | 220,438 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jan 2013 | 2,655 | 0 | - | - | Stock Option (Right to Buy) | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Gift of securities by or to the insider at price $ 0.00 per share. | 11 Jan 2013 | 460 | 219,978 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jan 2013 | 11,855 | 0 | - | - | Stock Option (Right to Buy) | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jan 2013 | 11,855 | 217,783 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2012 | 3,054 | 62,187 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2012 | 4,874 | 337,750 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Nov 2012 | 4,874 | 205,928 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Nov 2012 | 5,161 | 210,802 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Nov 2012 | 5,161 | 0 | - | - | Stock Option (Right to Buy) | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Nov 2012 | 6,800 | 205,841 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Nov 2012 | 200 | 205,641 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2012 | 11,000 | 591,577 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2012 | 5,000 | 65,241 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2012 | 5,000 | 342,624 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2012 | 5,000 | 137,486 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2012 | 5,000 | 284,386 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2012 | 5,000 | 212,641 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 24 Aug 2012 | 3,483 | 60,241 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 24 Aug 2012 | 17,700 | 135,347 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Aug 2012 | 4,121 | 157,168 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Aug 2012 | 4,121 | 170,879 | - | - | Stock Option (Right to Buy) | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 24 Aug 2012 | 2,861 | 132,486 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 24 Aug 2012 | 4,121 | 153,047 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2012 | 10,681 | 580,577 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2012 | 3,057 | 63,724 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2012 | 4,596 | 337,624 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2012 | 4,877 | 153,047 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Aug 2012 | 4,644 | 207,641 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 13 Aug 2012 | 21,892 | 215,393 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 13 Aug 2012 | 3,108 | 212,285 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2012 | 60,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 07 Aug 2012 | 60,000 | 157,924 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2012 | 60,000 | 217,924 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2012 | 64,516 | 667,007 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 Aug 2012 | 36,200 | 591,258 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2012 | 80,645 | 0 | - | - | Stock Option (Right to Buy) | |
| Rick E. Winningham | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2012 | 80,645 | 602,491 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2012 | 64,516 | 0 | - | - | Stock Option (Right to Buy) | |
| Rick E. Winningham | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 Aug 2012 | 39,549 | 627,458 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 Aug 2012 | 123,917 | 66,781 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2012 | 91,667 | 8,333 | - | - | Stock Option (Right to Buy) | |
| David L. Brinkley | Head of Business Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2012 | 15,090 | 0 | - | - | Common Stock (Right to Buy) | |
| David L. Brinkley | Head of Business Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2012 | 15,090 | 190,698 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2012 | 91,667 | 175,608 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 30 Jul 2012 | 7,546 | 279,386 | - | - | CommonStock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 29 May 2012 | 20,000 | 157,924 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2012 | 10,681 | 521,846 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2012 | 2,402 | 83,941 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2012 | 3,832 | 342,220 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2012 | 3,832 | 177,924 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 May 2012 | 3,832 | 237,285 | - | - | Common Stock | |
| George M. Whitesides | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 568,571 | - | - | Common Stock | |
| George M. Whitesides | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Arnold J. Levine | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 79,988 | - | - | Common Stock | |
| Arnold J. Levine | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| William H. Waltrip | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| William H. Waltrip | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 62,258 | - | - | Common Stock | |
| Peter S. Ringrose | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 24,000 | - | - | Common Stock | |
| Peter S. Ringrose | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| William D. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 46,129 | - | - | Common Stock | |
| William D. Young | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Burton G. Malkiel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Burton G. Malkiel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 30,000 | - | - | Common Stock | |
| Robert V. Gunderson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Robert V. Gunderson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 78,164 | - | - | Common Stock | |
| Henrietta Fore | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 6,000 | - | - | Stock Option (Right to Buy) | |
| Henrietta Fore | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2012 | 6,000 | 21,000 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2012 | 30,967 | 532,527 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2012 | 32,258 | 0 | - | - | Stock Option (Right to Buy) | |
| Rick E. Winningham | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2012 | 32,258 | 501,560 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 May 2012 | 30,967 | 0 | - | - | Stock Option (Right to Buy) | |
| Jeffrey M. Drazan | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 May 2012 | 8,586 | 33,465 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2012 | 21,386 | 469,302 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2012 | 5,318 | 86,343 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2012 | 9,621 | 346,052 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2012 | 10,018 | 181,756 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 20 Feb 2012 | 9,747 | 241,117 | - | - | Common Stock | |
| Rick E. Winningham | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2012 | 11,000 | 490,688 | - | - | Common Stock | |
| David L. Brinkley | Head of Business Dev. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2012 | 5,000 | 91,661 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2012 | 5,000 | 355,673 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2012 | 5,000 | 191,774 | - | - | Common Stock | |
| Leonard M. Blum | Sr VP, Chief Comm. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2012 | 5,000 | 286,932 | - | - | Common Stock | |
| Mathai Mammen | SVP, Research & Early Clin Dev | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2012 | 5,000 | 250,864 | - | - | Common Stock | |
| Michael W. Aguiar | Sr VP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 09 Dec 2011 | 10,000 | 186,774 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Nov 2011 | 16,129 | 370,673 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 28 Nov 2011 | 20,000 | 350,673 | - | - | Common Stock | |
| Bradford J. Shafer | Sr VP, Gen. Counsel, Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Nov 2011 | 16,129 | 0 | - | - | Stock Option (Right to Buy) |