965.4K XNAS Volume
XNAS 20 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Bahram Valamehr | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 1,300,000 | 1,300,000 | - | - | Stock Option (Right to Buy) | |
| Cindy Tahl | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 275,000 | 275,000 | - | - | Stock Option (Right to Buy) | |
| Cindy Tahl | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 70,000 | 406,707 (0%) | 0% | 0 | Common Stock | |
| Jerome Charles Bressi | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 65,000 | 335,203 (0%) | 0% | 0 | Common Stock | |
| Jerome Charles Bressi | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jan 2025 | 250,000 | 250,000 | - | - | Stock Option (Right to Buy) | |
| Cindy Tahl | See Remarks | Sale of securities on an exchange or to another person at price $ 1.55 per share. | 10 Jan 2025 | 5,654 | 336,707 (0%) | 0% | 1.6 | 8,764 | Common Stock |
| Bahram Valamehr | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 1.54 per share. | 10 Jan 2025 | 8,705 | 349,364 (0%) | 0% | 1.5 | 13,406 | Common Stock |
| Jerome Charles Bressi | See Remarks | Sale of securities on an exchange or to another person at price $ 1.55 per share. | 10 Jan 2025 | 5,980 | 270,203 (0%) | 0% | 1.6 | 9,269 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2024 | 200,000 | 342,361 (0%) | 0% | 0 | Common Stock | |
| Bahram Valamehr | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2024 | 200,000 | 358,069 (0%) | 0% | 0 | Common Stock | |
| Neelufar Mozaffarian | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2024 | 80,000 | 80,000 | - | - | Stock Option (Right to Buy) | |
| William H. Rastetter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2024 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Robert S. Epstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2024 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2024 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| John D. Mendlein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2024 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Shefali Agarwal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2024 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Michael Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2024 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Karin Jooss | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2024 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Edward J. Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 7.77 per share. | 04 Mar 2024 | 2,447 | 101,479 (0%) | 0% | 7.8 | 19,013 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 425,000 | 425,000 | - | - | Stock Option (Right to Buy) | |
| J. Edward Dulac | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 425,000 | 425,000 | - | - | Stock Option (Right to Buy) | |
| Valamehr Bahram | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 450,000 | 450,000 | - | - | Stock Option (Right to Buy) | |
| J. Wolchko Scott | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2024 | 500,000 | 500,000 | - | - | Stock Option (Right to Buy) | |
| J. Edward Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 5.00 per share. | 29 Jan 2024 | 1,849 | 103,926 (0%) | 0% | 5 | 9,245 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 4.37 per share. | 09 Jan 2024 | 10,874 | 142,361 (0%) | 0% | 4.4 | 47,519 | Common Stock |
| Valamehr Bahram | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 4.38 per share. | 09 Jan 2024 | 11,271 | 158,069 (0%) | 0% | 4.4 | 49,367 | Common Stock |
| Wolchko Scott J. | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 4.37 per share. | 09 Jan 2024 | 14,391 | 371,248 (0%) | 0% | 4.4 | 62,889 | Common Stock |
| J. Edward Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 4.37 per share. | 09 Jan 2024 | 7,028 | 105,775 (0%) | 0% | 4.4 | 30,712 | Common Stock |
| Edward J. Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 3.66 per share. | 02 Jan 2024 | 5,182 | 112,803 (0%) | 0% | 3.7 | 18,966 | Common Stock |
| J. Dulac Edward | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 3.50 per share. | 18 Dec 2023 | 1,585 | 117,985 (0%) | 0% | 3.5 | 5,548 | Common Stock |
| Tahl Cindy | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 2.40 per share. | 09 Nov 2023 | 24,363 | 153,235 (0%) | 0% | 2.4 | 58,471 | Common Stock |
| Edward J. Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 2.80 per share. | 18 Aug 2023 | 4,718 | 119,570 (0%) | 0% | 2.8 | 13,210 | Common Stock |
| Edward J. Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 4.83 per share. | 05 Jul 2023 | 5,182 | 124,288 (0%) | 0% | 4.8 | 25,029 | Common Stock |
| Brian T. Powl | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 4.87 per share. | 05 Jul 2023 | 3,854 | 41,146 (0%) | 0% | 4.9 | 18,769 | Common Stock |
| Robert M. Hershberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| William H. Rastetter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Robert S. Epstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| John D. Mendlein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Shefali Agarwal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Michael Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Karin Jooss | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Yu-Waye Chu | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 6.52 per share. | 18 Apr 2023 | 215 | 142,993 (0%) | 0% | 6.5 | 1,402 | Common Stock |
| Yu-Waye Chu | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 6.58 per share. | 18 Apr 2023 | 2,317 | 140,676 (0%) | 0% | 6.6 | 15,246 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2023 | 500,000 | 500,000 | - | - | Stock Option (Right to Buy) | |
| Cindy Tahl | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2023 | 425,000 | 425,000 | - | - | Stock Option (Right to Buy) | |
| Bahram Valamehr | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2023 | 450,000 | 450,000 | - | - | Stock Option (Right to Buy) | |
| Edward J. Dulac | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2023 | 425,000 | 425,000 | - | - | Stock Option (Right to Buy) | |
| Yu-Waye Chu | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2023 | 425,000 | 425,000 | - | - | Stock Option (Right to Buy) | |
| Brian T. Powl | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2023 | 425,000 | 425,000 | - | - | Stock Option (Right to Buy) | |
| John D. Mendlein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Jan 2023 | 28,461 | 0 | - | - | Stock Option (Right to Buy) | |
| John D. Mendlein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.37 per share. | 19 Jan 2023 | 28,461 | 311,231 (0%) | 0% | 1.4 | 38,992 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.37 per share. | 12 Jan 2023 | 423 | 169,340 (0%) | 0% | 1.4 | 580 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jan 2023 | 423 | 0 | - | - | Stock Option (Right to Buy) | |
| John D. Mendlein | Director | Purchase of securities on an exchange or from another person at price $ 5.43 per share. | 11 Jan 2023 | 36,631 | 282,770 (0%) | 0% | 5.4 | 198,906 | Common Stock |
| John D. Mendlein | Director | Purchase of securities on an exchange or from another person at price $ 5.67 per share. | 11 Jan 2023 | 88,048 | 246,139 (0%) | 0% | 5.7 | 499,232 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 5.24 per share. | 10 Jan 2023 | 45,907 | 385,639 (0%) | 0% | 5.2 | 240,553 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 5.24 per share. | 10 Jan 2023 | 11,553 | 177,598 (0%) | 0% | 5.2 | 60,538 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 5.24 per share. | 10 Jan 2023 | 10,917 | 168,917 (0%) | 0% | 5.2 | 57,205 | Common Stock |
| Edward J. Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 5.24 per share. | 10 Jan 2023 | 7,331 | 129,470 (0%) | 0% | 5.2 | 38,414 | Common Stock |
| Yu-Waye Chu | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 5.24 per share. | 10 Jan 2023 | 7,825 | 143,208 (0%) | 0% | 5.2 | 41,003 | Common Stock |
| Mark Plavsic | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 5.24 per share. | 10 Jan 2023 | 3,418 | 123,705 (0%) | 0% | 5.2 | 17,910 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.70 per share. | 21 Jul 2022 | 30,000 | 461,546 (0%) | 0% | 2.7 | 81,000 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2022 | 6,246 | 0 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2022 | 30,000 | 6,246 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 33.28 per share. | 21 Jul 2022 | 620 | 431,546 (0%) | 0% | 33.3 | 20,634 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.61 per share. | 21 Jul 2022 | 2,703 | 432,166 (0%) | 0% | 32.6 | 88,145 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.33 per share. | 21 Jul 2022 | 2,923 | 434,869 (0%) | 0% | 31.3 | 91,578 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.70 per share. | 21 Jul 2022 | 6,246 | 437,792 (0%) | 0% | 2.7 | 16,864 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 33.07 per share. | 21 Jul 2022 | 19,171 | 431,546 (0%) | 0% | 33.1 | 633,985 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.54 per share. | 21 Jul 2022 | 10,829 | 450,717 (0%) | 0% | 32.5 | 352,376 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 30.23 per share. | 07 Jul 2022 | 17,158 | 179,834 (0%) | 0% | 30.2 | 518,686 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2022 | 17,158 | 13,156 | - | - | Stock Option (Right to Buy) | |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 07 Jul 2022 | 17,158 | 196,992 (0%) | 0% | 2.7 | 46,841 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.84 per share. | 06 Jul 2022 | 2,000 | 181,834 (0%) | 0% | 4.8 | 9,680 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2022 | 5,842 | 30,314 | - | - | Stock Option (Right to Buy) | |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2022 | 2,000 | 8,704 | - | - | Stock Option (Right to Buy) | |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 30.07 per share. | 06 Jul 2022 | 7,842 | 179,834 (0%) | 0% | 30.1 | 235,809 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 06 Jul 2022 | 5,842 | 187,676 (0%) | 0% | 2.7 | 15,949 | Common Stock |
| Mark Plavsic | Chief Technical Officer | Sale of securities on an exchange or to another person at price $ 24.61 per share. | 05 Jul 2022 | 3,719 | 127,123 (0%) | 0% | 24.6 | 91,525 | Common Stock |
| Brian T. Powl | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jun 2022 | 70,000 | 70,000 | - | - | Stock Option (Right to Buy) | |
| Brian T. Powl | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jun 2022 | 45,000 | 45,000 (0%) | 0% | 0 | Common Stock | |
| Robert M. Hershberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 8,650 | 10,659 (0%) | 0% | 0 | Common Stock | |
| Robert M. Hershberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 11,893 | 11,893 | - | - | Stock Option (Right to Buy) | |
| William H. Rastetter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 11,893 | 11,893 | - | - | Stock Option (Right to Buy) | |
| William H. Rastetter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 8,650 | 11,331 (0%) | 0% | 0 | Common Stock | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 11,893 | 11,893 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 8,650 | 9,892 (0%) | 0% | 0 | Common Stock | |
| John D. Mendlein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 11,893 | 11,893 | - | - | Stock Option (Right to Buy) | |
| John D. Mendlein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 8,650 | 166,741 (0%) | 0% | 0 | Common Stock | |
| Shefali Agarwal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 8,650 | 10,490 (0%) | 0% | 0 | Common Stock | |
| Shefali Agarwal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 11,893 | 11,893 | - | - | Stock Option (Right to Buy) | |
| Michael Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 8,650 | 11,331 (0%) | 0% | 0 | Common Stock | |
| Michael Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 11,893 | 11,893 | - | - | Stock Option (Right to Buy) | |
| Karin Jooss | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 11,893 | 11,893 | - | - | Stock Option (Right to Buy) | |
| Karin Jooss | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 8,650 | 9,848 (0%) | 0% | 0 | Common Stock | |
| Shefali Agarwal | Director | Sale of securities on an exchange or to another person at price $ 21.89 per share. | 07 Jun 2022 | 841 | 1,840 (0%) | 0% | 21.9 | 18,409 | Common Stock |
| Robert M. Hershberg | Director | Sale of securities on an exchange or to another person at price $ 22.75 per share. | 03 Jun 2022 | 672 | 2,009 (0%) | 0% | 22.8 | 15,288 | Common Stock |
| Timothy P. Coughlin | Director | Sale of securities on an exchange or to another person at price $ 22.81 per share. | 03 Jun 2022 | 1,439 | 57,632 (0%) | 0% | 22.8 | 32,824 | Common Stock |
| John D. Mendlein | Director | Sale of securities on an exchange or to another person at price $ 22.79 per share. | 03 Jun 2022 | 1,364 | 158,091 (0%) | 0% | 22.8 | 31,086 | Common Stock |
| Karin Jooss | Director | Sale of securities on an exchange or to another person at price $ 22.82 per share. | 03 Jun 2022 | 1,483 | 1,198 (0%) | 0% | 22.8 | 33,842 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 22.96 per share. | 01 Jun 2022 | 25,000 | 189,151 (0%) | 0% | 23.0 | 574,000 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.55 per share. | 01 Jun 2022 | 25,000 | 214,151 (0%) | 0% | 6.6 | 163,750 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2022 | 25,000 | 54,210 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 36.70 per share. | 21 Apr 2022 | 2,220 | 432,549 (0%) | 0% | 36.7 | 81,474 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.70 per share. | 21 Apr 2022 | 30,000 | 461,546 (0%) | 0% | 2.7 | 81,000 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 34.57 per share. | 21 Apr 2022 | 22,715 | 438,831 (0%) | 0% | 34.6 | 785,258 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 35.73 per share. | 21 Apr 2022 | 4,062 | 434,769 (0%) | 0% | 35.7 | 145,135 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 37.90 per share. | 21 Apr 2022 | 1,003 | 431,546 (0%) | 0% | 37.9 | 38,014 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.70 per share. | 21 Apr 2022 | 10,000 | 441,546 (0%) | 0% | 2.7 | 27,000 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 34.54 per share. | 21 Apr 2022 | 9,162 | 432,384 (0%) | 0% | 34.5 | 316,455 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 35.15 per share. | 21 Apr 2022 | 838 | 431,546 (0%) | 0% | 35.2 | 29,456 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Apr 2022 | 30,000 | 46,246 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Apr 2022 | 10,000 | 36,246 | - | - | Stock Option (Right to Buy) | |
| Yu-Waye Chu | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 35.37 per share. | 19 Apr 2022 | 4,062 | 151,033 (0%) | 0% | 35.4 | 143,673 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2022 | 25,000 | 36,156 | - | - | Stock Option (Right to Buy) | |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 34.04 per share. | 14 Mar 2022 | 100 | 179,834 (0%) | 0% | 34.0 | 3,404 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 33.30 per share. | 14 Mar 2022 | 2,960 | 179,934 (0%) | 0% | 33.3 | 98,568 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 32.49 per share. | 14 Mar 2022 | 2,195 | 182,894 (0%) | 0% | 32.5 | 71,316 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 31.66 per share. | 14 Mar 2022 | 3,067 | 185,089 (0%) | 0% | 31.7 | 97,101 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 14 Mar 2022 | 25,000 | 204,834 (0%) | 0% | 2.7 | 68,250 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 30.36 per share. | 14 Mar 2022 | 16,678 | 188,156 (0%) | 0% | 30.4 | 506,344 | Common Stock |
| John D. Mendlein | Director | Sale of securities on an exchange or to another person at price $ 34.73 per share. | 10 Mar 2022 | 19,493 | 171,524 (0%) | 0% | 34.7 | 676,992 | Common Stock |
| John D. Mendlein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 31,562 | 0 | - | - | Stock Option (Right to Buy) | |
| John D. Mendlein | Director | Sale of securities on an exchange or to another person at price $ 35.48 per share. | 10 Mar 2022 | 12,069 | 159,455 (0%) | 0% | 35.5 | 428,208 | Common Stock |
| John D. Mendlein | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.63 per share. | 10 Mar 2022 | 31,562 | 191,017 (0%) | 0% | 1.6 | 51,446 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2022 | 289,403 | 289,403 | - | - | Stock Option (Right to Buy) | |
| Cindy Tahl | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2022 | 33,302 | 189,151 (0%) | 0% | 0 | Common Stock | |
| Cindy Tahl | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2022 | 53,058 | 53,058 | - | - | Stock Option (Right to Buy) | |
| Bahram Valamehr | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2022 | 53,058 | 53,058 | - | - | Stock Option (Right to Buy) | |
| Bahram Valamehr | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2022 | 33,302 | 179,834 (0%) | 0% | 0 | Common Stock | |
| Edward J. Dulac | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2022 | 33,302 | 141,936 (0%) | 0% | 0 | Common Stock | |
| Edward J. Dulac | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2022 | 53,058 | 53,058 | - | - | Stock Option (Right to Buy) | |
| Yu-Waye Chu | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2022 | 53,058 | 53,058 | - | - | Stock Option (Right to Buy) | |
| Yu-Waye Chu | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2022 | 33,302 | 155,095 (0%) | 0% | 0 | Common Stock | |
| Mark Plavsic | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2022 | 33,302 | 130,842 (0%) | 0% | 0 | Common Stock | |
| Mark Plavsic | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Jan 2022 | 53,058 | 53,058 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2022 | 10,000 | 76,246 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.70 per share. | 20 Jan 2022 | 30,000 | 461,546 (0%) | 0% | 2.7 | 81,000 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2022 | 30,000 | 86,246 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 48.50 per share. | 11 Jan 2022 | 10,047 | 436,065 (0%) | 0% | 48.5 | 487,280 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 49.07 per share. | 11 Jan 2022 | 4,519 | 431,546 (0%) | 0% | 49.1 | 221,747 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 49.15 per share. | 11 Jan 2022 | 536 | 155,849 (0%) | 0% | 49.1 | 26,344 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 48.46 per share. | 11 Jan 2022 | 4,883 | 156,385 (0%) | 0% | 48.5 | 236,630 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 49.12 per share. | 11 Jan 2022 | 418 | 146,532 (0%) | 0% | 49.1 | 20,532 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 48.44 per share. | 11 Jan 2022 | 4,152 | 146,950 (0%) | 0% | 48.4 | 201,123 | Common Stock |
| Edward J. Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 49.16 per share. | 11 Jan 2022 | 390 | 108,634 (0%) | 0% | 49.2 | 19,172 | Common Stock |
| Edward J. Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 48.25 per share. | 11 Jan 2022 | 1,380 | 109,024 (0%) | 0% | 48.3 | 66,585 | Common Stock |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 49.10 per share. | 11 Jan 2022 | 418 | 121,793 (0%) | 0% | 49.1 | 20,524 | Common Stock |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 48.44 per share. | 11 Jan 2022 | 3,547 | 122,211 (0%) | 0% | 48.4 | 171,817 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 47.17 per share. | 10 Jan 2022 | 20,894 | 446,213 (0%) | 0% | 47.2 | 985,570 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 47.72 per share. | 10 Jan 2022 | 101 | 446,112 (0%) | 0% | 47.7 | 4,820 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 46.36 per share. | 10 Jan 2022 | 13,161 | 467,107 (0%) | 0% | 46.4 | 610,144 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 46.37 per share. | 10 Jan 2022 | 7,095 | 161,911 (0%) | 0% | 46.4 | 328,995 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 47.15 per share. | 10 Jan 2022 | 643 | 161,268 (0%) | 0% | 47.1 | 30,317 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 47.17 per share. | 10 Jan 2022 | 351 | 151,102 (0%) | 0% | 47.2 | 16,557 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 46.33 per share. | 10 Jan 2022 | 5,245 | 151,453 (0%) | 0% | 46.3 | 243,001 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 59.86 per share. | 03 Jan 2022 | 27,812 | 169,867 (0%) | 0% | 59.9 | 1,664,826 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 57.76 per share. | 03 Jan 2022 | 4,427 | 214,579 (0%) | 0% | 57.8 | 255,704 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 58.84 per share. | 03 Jan 2022 | 16,900 | 197,679 (0%) | 0% | 58.8 | 994,396 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.55 per share. | 03 Jan 2022 | 50,000 | 219,006 (0%) | 0% | 6.6 | 327,500 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2022 | 50,000 | 66,643 | - | - | Stock Option (Right to Buy) | |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 60.31 per share. | 03 Jan 2022 | 861 | 169,006 (0%) | 0% | 60.3 | 51,927 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 46.72 per share. | 13 Dec 2021 | 7,018 | 172,580 (0%) | 0% | 46.7 | 327,881 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 47.61 per share. | 13 Dec 2021 | 6,564 | 166,016 (0%) | 0% | 47.6 | 312,512 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 45.68 per share. | 13 Dec 2021 | 2,100 | 179,598 (0%) | 0% | 45.7 | 95,928 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 13 Dec 2021 | 25,000 | 181,698 (0%) | 0% | 2.7 | 68,250 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 48.75 per share. | 13 Dec 2021 | 7,718 | 158,298 (0%) | 0% | 48.8 | 376,253 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 49.27 per share. | 13 Dec 2021 | 1,600 | 156,698 (0%) | 0% | 49.3 | 78,832 | Common Stock |
| Bahram Valamehr | Chief R&D Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2021 | 25,000 | 61,156 | - | - | Stock Option (Right to Buy) | |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 50.42 per share. | 10 Dec 2021 | 900 | 130,261 (0%) | 0% | 50.4 | 45,378 | Common Stock |
| Yu-Waye Chu | Senior VP Clinical Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.32 per share. | 10 Dec 2021 | 7,500 | 133,258 (0%) | 0% | 16.3 | 122,400 | Common Stock |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 49.32 per share. | 10 Dec 2021 | 2,097 | 131,161 (0%) | 0% | 49.3 | 103,424 | Common Stock |
| Yu-Waye Chu | Senior VP Clinical Development | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2021 | 7,500 | 105,000 | - | - | Stock Option (Right to Buy) | |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 55.60 per share. | 10 Dec 2021 | 5 | 125,758 (0%) | 0% | 55.6 | 278 | Common Stock |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 54.58 per share. | 10 Dec 2021 | 600 | 126,763 (0%) | 0% | 54.6 | 32,748 | Common Stock |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 53.66 per share. | 10 Dec 2021 | 1,031 | 126,363 (0%) | 0% | 53.7 | 55,323 | Common Stock |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 52.37 per share. | 10 Dec 2021 | 1,822 | 127,394 (0%) | 0% | 52.4 | 95,418 | Common Stock |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 51.08 per share. | 10 Dec 2021 | 1,045 | 129,216 (0%) | 0% | 51.1 | 53,379 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Nov 2021 | 60,958 | 169,006 (0%) | 0% | 0 | Common Stock | |
| Bahram Valamehr | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Nov 2021 | 60,958 | 156,698 (0%) | 0% | 0 | Common Stock | |
| Edward J. Dulac | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Nov 2021 | 59,540 | 111,944 (0%) | 0% | 0 | Common Stock | |
| Yu-Waye Chu | Senior VP Clinical Development | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Nov 2021 | 60,958 | 125,758 (0%) | 0% | 0 | Common Stock | |
| Mark Plavsic | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Nov 2021 | 59,540 | 97,540 (0%) | 0% | 0 | Common Stock | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 54.27 per share. | 18 Nov 2021 | 20,000 | 393,793 (0%) | 0% | 54.3 | 1,085,400 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.70 per share. | 18 Nov 2021 | 20,000 | 413,793 (0%) | 0% | 2.7 | 54,000 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Nov 2021 | 86,475 | 480,268 (0%) | 0% | 0 | Common Stock | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Nov 2021 | 20,000 | 79,446 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.84 per share. | 21 Oct 2021 | 4,846 | 408,639 (0%) | 0% | 4.8 | 23,455 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Oct 2021 | 15,154 | 99,446 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Oct 2021 | 4,846 | 0 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Oct 2021 | 10,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Oct 2021 | 30,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 58.88 per share. | 21 Oct 2021 | 30,000 | 393,793 (0%) | 0% | 58.9 | 1,766,400 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.70 per share. | 21 Oct 2021 | 15,154 | 423,793 (0%) | 0% | 2.7 | 40,916 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 21 Oct 2021 | 10,000 | 403,793 (0%) | 0% | 2.7 | 27,300 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 60.63 per share. | 21 Oct 2021 | 14,765 | 393,793 (0%) | 0% | 60.6 | 895,202 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 59.82 per share. | 21 Oct 2021 | 15,235 | 408,558 (0%) | 0% | 59.8 | 911,358 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 21 Oct 2021 | 30,000 | 423,793 (0%) | 0% | 2.7 | 81,900 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.55 per share. | 01 Oct 2021 | 50,000 | 158,048 (0%) | 0% | 6.6 | 327,500 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2021 | 50,000 | 116,643 | - | - | Stock Option (Right to Buy) | |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 59.68 per share. | 01 Oct 2021 | 11,844 | 108,048 (0%) | 0% | 59.7 | 706,862 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 58.96 per share. | 01 Oct 2021 | 21,844 | 119,892 (0%) | 0% | 59.0 | 1,287,966 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 58.03 per share. | 01 Oct 2021 | 16,312 | 141,736 (0%) | 0% | 58.0 | 946,634 | Common Stock |
| Edward J. Dulac | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2021 | 17,325 | 142,675 | - | - | Stock Option (Right to Buy) | |
| Edward J. Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 62.53 per share. | 28 Sep 2021 | 19,460 | 52,404 (0%) | 0% | 62.5 | 1,216,834 | Common Stock |
| Edward J. Dulac | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 35.52 per share. | 28 Sep 2021 | 17,325 | 71,864 (0%) | 0% | 35.5 | 615,384 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 13 Sep 2021 | 25,000 | 120,740 (0%) | 0% | 2.7 | 68,250 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Sep 2021 | 25,000 | 86,156 | - | - | Stock Option (Right to Buy) | |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 67.46 per share. | 13 Sep 2021 | 800 | 95,740 (0%) | 0% | 67.5 | 53,965 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 65.94 per share. | 13 Sep 2021 | 15,809 | 104,931 (0%) | 0% | 65.9 | 1,042,414 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 66.84 per share. | 13 Sep 2021 | 8,391 | 96,540 (0%) | 0% | 66.8 | 560,879 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Aug 2021 | 20,000 | 4,846 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.84 per share. | 19 Aug 2021 | 20,000 | 413,793 (0%) | 0% | 4.8 | 96,700 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 88.01 per share. | 19 Aug 2021 | 20,000 | 393,793 (0%) | 0% | 88.0 | 1,760,204 | Common Stock |
| Edward J. Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 19 Aug 2021 | 63 | 54,539 (0%) | 0% | 90 | 5,670 | Common Stock |
| Edward J. Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 88.65 per share. | 19 Aug 2021 | 1,474 | 54,602 (0%) | 0% | 88.6 | 130,670 | Common Stock |
| Edward J. Dulac | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 87.90 per share. | 19 Aug 2021 | 1,937 | 56,076 (0%) | 0% | 87.9 | 170,262 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 22 Jul 2021 | 30,000 | 423,793 (0%) | 0% | 2.7 | 81,900 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jul 2021 | 20,000 | 24,846 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jul 2021 | 10,000 | 90,000 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jul 2021 | 30,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 85.28 per share. | 22 Jul 2021 | 30,000 | 393,793 (0%) | 0% | 85.3 | 2,558,538 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.84 per share. | 22 Jul 2021 | 20,000 | 423,793 (0%) | 0% | 4.8 | 96,800 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 22 Jul 2021 | 10,000 | 403,793 (0%) | 0% | 2.7 | 27,300 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 86.90 per share. | 22 Jul 2021 | 1,600 | 393,793 (0%) | 0% | 86.9 | 139,044 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 86.19 per share. | 22 Jul 2021 | 21,773 | 395,393 (0%) | 0% | 86.2 | 1,876,711 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 85.38 per share. | 22 Jul 2021 | 6,627 | 417,166 (0%) | 0% | 85.4 | 565,821 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2021 | 27,685 | 22,315 | - | - | Stock Option (Right to Buy) | |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2021 | 15,383 | 166,643 | - | - | Stock Option (Right to Buy) | |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2021 | 6,932 | 27,628 | - | - | Stock Option (Right to Buy) | |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2021 | 5,534 | 0 | - | - | Stock Option (Right to Buy) | |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 84.56 per share. | 01 Jul 2021 | 50,000 | 108,048 (0%) | 0% | 84.6 | 4,228,000 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 95.30 per share. | 01 Jul 2021 | 100 | 158,048 (0%) | 0% | 95.3 | 9,530 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 94.63 per share. | 01 Jul 2021 | 1,825 | 158,148 (0%) | 0% | 94.6 | 172,694 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 93.31 per share. | 01 Jul 2021 | 400 | 159,973 (0%) | 0% | 93.3 | 37,323 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 92.26 per share. | 01 Jul 2021 | 432 | 160,373 (0%) | 0% | 92.3 | 39,856 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 91.07 per share. | 01 Jul 2021 | 225 | 160,805 (0%) | 0% | 91.1 | 20,490 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 90.30 per share. | 01 Jul 2021 | 707 | 161,030 (0%) | 0% | 90.3 | 63,843 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 88.93 per share. | 01 Jul 2021 | 400 | 161,737 (0%) | 0% | 88.9 | 35,573 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 87.90 per share. | 01 Jul 2021 | 1,145 | 162,137 (0%) | 0% | 87.9 | 100,640 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 86.56 per share. | 01 Jul 2021 | 200 | 163,282 (0%) | 0% | 86.6 | 17,312 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 84.83 per share. | 01 Jul 2021 | 100 | 163,482 (0%) | 0% | 84.8 | 8,483 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.55 per share. | 01 Jul 2021 | 15,383 | 163,582 (0%) | 0% | 6.6 | 100,759 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.89 per share. | 01 Jul 2021 | 27,685 | 148,199 (0%) | 0% | 4.9 | 135,380 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.84 per share. | 01 Jul 2021 | 6,932 | 120,514 (0%) | 0% | 4.8 | 33,551 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.87 per share. | 01 Jul 2021 | 5,534 | 113,582 (0%) | 0% | 7.9 | 43,553 | Common Stock |
| Mark Plavsic | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2021 | 38,000 | 38,000 (0%) | 0% | 0 | Common Stock | |
| Mark Plavsic | Chief Technical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2021 | 18,500 | 18,500 | - | - | Stock Option (Right to Buy) | |
| Robert M. Hershberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 4,334 | 4,334 | - | - | Stock Option (Right to Buy) | |
| Robert M. Hershberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,681 | 2,681 (0%) | 0% | 0 | Common Stock | |
| William H. Rastetter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 4,334 | 4,334 | - | - | Stock Option (Right to Buy) | |
| William H. Rastetter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,681 | 2,681 (0%) | 0% | 0 | Common Stock | |
| Robert S. Epstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 4,334 | 4,334 | - | - | Stock Option (Right to Buy) | |
| Robert S. Epstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,681 | 2,681 (0%) | 0% | 0 | Common Stock | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 4,334 | 4,334 | - | - | Stock Option (Right to Buy) | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,681 | 59,071 (0%) | 0% | 0 | Common Stock | |
| John D. Mendlein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 4,334 | 4,334 | - | - | Stock Option (Right to Buy) | |
| John D. Mendlein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,681 | 159,455 (0%) | 0% | 0 | Common Stock | |
| Shefali Agarwal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,681 | 2,681 (0%) | 0% | 0 | Common Stock | |
| Shefali Agarwal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 4,334 | 4,334 | - | - | Stock Option (Right to Buy) | |
| Michael Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,681 | 2,681 (0%) | 0% | 0 | Common Stock | |
| Michael Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 4,334 | 4,334 | - | - | Stock Option (Right to Buy) | |
| Karin Jooss | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 2,681 | 2,681 (0%) | 0% | 0 | Common Stock | |
| Karin Jooss | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 4,334 | 4,334 | - | - | Stock Option (Right to Buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 May 2021 | 20,000 | 44,846 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 77.16 per share. | 20 May 2021 | 20,000 | 393,793 (0%) | 0% | 77.2 | 1,543,292 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.84 per share. | 20 May 2021 | 20,000 | 413,793 (0%) | 0% | 4.8 | 96,700 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Apr 2021 | 10,000 | 130,000 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 22 Apr 2021 | 30,000 | 423,793 (0%) | 0% | 2.7 | 81,900 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 85.54 per share. | 22 Apr 2021 | 30,000 | 393,793 (0%) | 0% | 85.5 | 2,566,212 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 22 Apr 2021 | 10,000 | 403,793 (0%) | 0% | 2.7 | 27,300 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.62 per share. | 22 Apr 2021 | 14,846 | 418,639 (0%) | 0% | 6.6 | 98,281 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.84 per share. | 22 Apr 2021 | 5,154 | 423,793 (0%) | 0% | 4.8 | 24,920 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 85.24 per share. | 22 Apr 2021 | 30,000 | 393,793 (0%) | 0% | 85.2 | 2,557,284 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Apr 2021 | 30,000 | 140,000 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Apr 2021 | 14,846 | 0 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Apr 2021 | 5,154 | 64,846 | - | - | Stock Option (right to buy) | |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 82.91 per share. | 16 Apr 2021 | 900 | 66,300 (0%) | 0% | 82.9 | 74,619 | Common stock |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 81.80 per share. | 16 Apr 2021 | 875 | 67,200 (0%) | 0% | 81.8 | 71,575 | Common stock |
| Yu-Waye Chu | Senior VP Clinical Development | Sale of securities on an exchange or to another person at price $ 84.41 per share. | 16 Apr 2021 | 1,500 | 64,800 (0%) | 0% | 84.4 | 126,615 | Common stock |
| Cindy Tahl | See Remarks | Sale of securities on an exchange or to another person at price $ 87.45 per share. | 01 Apr 2021 | 400 | 108,048 (0%) | 0% | 87.4 | 34,979 | Common Stock |
| Cindy Tahl | See Remarks | Sale of securities on an exchange or to another person at price $ 86.76 per share. | 01 Apr 2021 | 5,299 | 108,448 (0%) | 0% | 86.8 | 459,733 | Common Stock |
| Cindy Tahl | See Remarks | Sale of securities on an exchange or to another person at price $ 85.98 per share. | 01 Apr 2021 | 4,835 | 113,747 (0%) | 0% | 86.0 | 415,733 | Common Stock |
| Cindy Tahl | See Remarks | Sale of securities on an exchange or to another person at price $ 84.48 per share. | 01 Apr 2021 | 2,200 | 118,582 (0%) | 0% | 84.5 | 185,865 | Common Stock |
| Cindy Tahl | See Remarks | Sale of securities on an exchange or to another person at price $ 82.69 per share. | 01 Apr 2021 | 4,556 | 124,272 (0%) | 0% | 82.7 | 376,714 | Common Stock |
| Cindy Tahl | See Remarks | Sale of securities on an exchange or to another person at price $ 81.48 per share. | 01 Apr 2021 | 8,220 | 128,828 (0%) | 0% | 81.5 | 669,731 | Common Stock |
| Cindy Tahl | See Remarks | Sale of securities on an exchange or to another person at price $ 80.49 per share. | 01 Apr 2021 | 1,000 | 137,048 (0%) | 0% | 80.5 | 80,494 | Common Stock |
| Cindy Tahl | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.87 per share. | 01 Apr 2021 | 1,851 | 138,048 (0%) | 0% | 7.9 | 14,567 | Common Stock |
| Cindy Tahl | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.90 per share. | 01 Apr 2021 | 28,149 | 136,197 (0%) | 0% | 2.9 | 81,632 | Common Stock |
| Cindy Tahl | See Remarks | Sale of securities on an exchange or to another person at price $ 83.40 per share. | 01 Apr 2021 | 3,490 | 120,782 (0%) | 0% | 83.4 | 291,080 | Common Stock |
| Cindy Tahl | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2021 | 1,851 | 10,458 | - | - | Stock Option Right to Buy | |
| Cindy Tahl | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2021 | 28,149 | 0 | - | - | Stock Option (Right to Buy) | |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.90 per share. | 15 Mar 2021 | 25,000 | 120,740 (0%) | 0% | 2.9 | 72,500 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2021 | 25,000 | 16,156 | - | - | Stock Option (Right to Buy) | |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 94.59 per share. | 15 Mar 2021 | 1,018 | 95,740 (0%) | 0% | 94.6 | 96,297 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 93.75 per share. | 15 Mar 2021 | 3,205 | 96,758 (0%) | 0% | 93.7 | 300,461 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 92.64 per share. | 15 Mar 2021 | 8,404 | 99,963 (0%) | 0% | 92.6 | 778,578 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 91.94 per share. | 15 Mar 2021 | 8,416 | 108,367 (0%) | 0% | 91.9 | 773,782 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 90.89 per share. | 15 Mar 2021 | 3,957 | 116,783 (0%) | 0% | 90.9 | 359,654 | Common Stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 78.60 per share. | 08 Mar 2021 | 3,298 | 94,722 (0%) | 0% | 78.6 | 259,236 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 86.70 per share. | 08 Mar 2021 | 800 | 73,020 (0%) | 0% | 86.7 | 69,360 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 85.50 per share. | 08 Mar 2021 | 2,900 | 73,820 (0%) | 0% | 85.5 | 247,956 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 84.20 per share. | 08 Mar 2021 | 2,728 | 76,720 (0%) | 0% | 84.2 | 229,705 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 83.46 per share. | 08 Mar 2021 | 2,480 | 79,448 (0%) | 0% | 83.5 | 206,989 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 81.60 per share. | 08 Mar 2021 | 2,993 | 81,928 (0%) | 0% | 81.6 | 244,224 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 80.73 per share. | 08 Mar 2021 | 5,174 | 84,921 (0%) | 0% | 80.7 | 417,722 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 79.58 per share. | 08 Mar 2021 | 4,627 | 90,095 (0%) | 0% | 79.6 | 368,236 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 99.08 per share. | 18 Feb 2021 | 1,401 | 412,392 (0%) | 0% | 99.1 | 138,817 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2021 | 20,000 | 14,846 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 103.16 per share. | 18 Feb 2021 | 5,547 | 393,793 (0%) | 0% | 103.2 | 572,206 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 102.26 per share. | 18 Feb 2021 | 8,602 | 399,340 (0%) | 0% | 102.3 | 879,661 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 101.42 per share. | 18 Feb 2021 | 2,602 | 407,942 (0%) | 0% | 101.4 | 263,883 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 100.48 per share. | 18 Feb 2021 | 1,848 | 410,544 (0%) | 0% | 100.5 | 185,691 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.62 per share. | 18 Feb 2021 | 20,000 | 413,793 (0%) | 0% | 6.6 | 132,400 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2021 | 14,411 | 98,020 (0%) | 0% | 0 | Common stock | |
| Daniel D. Shoemaker | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2021 | 5,481 | 5,481 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 20 Jan 2021 | 10,000 | 403,793 (0%) | 0% | 2.7 | 27,300 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2021 | 20,000 | 34,846 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2021 | 10,000 | 170,000 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jan 2021 | 30,000 | 180,000 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2021 | 16,441 | 16,441 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 100.01 per share. | 20 Jan 2021 | 3,075 | 393,793 (0%) | 0% | 100.0 | 307,545 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 99.35 per share. | 20 Jan 2021 | 6,520 | 396,868 (0%) | 0% | 99.3 | 647,732 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 98.45 per share. | 20 Jan 2021 | 7,638 | 403,388 (0%) | 0% | 98.4 | 751,952 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 97.23 per share. | 20 Jan 2021 | 12,767 | 411,026 (0%) | 0% | 97.2 | 1,241,383 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.62 per share. | 20 Jan 2021 | 20,000 | 423,793 (0%) | 0% | 6.6 | 132,400 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 106.96 per share. | 20 Jan 2021 | 200 | 393,793 (0%) | 0% | 107.0 | 21,391 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 106.03 per share. | 20 Jan 2021 | 645 | 393,993 (0%) | 0% | 106.0 | 68,392 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 105.25 per share. | 20 Jan 2021 | 4,271 | 394,638 (0%) | 0% | 105.2 | 449,517 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 104.13 per share. | 20 Jan 2021 | 9,156 | 398,909 (0%) | 0% | 104.1 | 953,438 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 103.23 per share. | 20 Jan 2021 | 3,895 | 408,065 (0%) | 0% | 103.2 | 402,086 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 101.91 per share. | 20 Jan 2021 | 3,300 | 411,960 (0%) | 0% | 101.9 | 336,314 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 101.09 per share. | 20 Jan 2021 | 5,993 | 415,260 (0%) | 0% | 101.1 | 605,808 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 100.16 per share. | 20 Jan 2021 | 2,540 | 421,253 (0%) | 0% | 100.2 | 254,411 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 20 Jan 2021 | 30,000 | 423,793 (0%) | 0% | 2.7 | 81,900 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2021 | 43,231 | 393,793 (0%) | 0% | 0 | Common stock | |
| Cindy Tahl | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2021 | 18,013 | 108,048 (0%) | 0% | 0 | Common stock | |
| Cindy Tahl | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2021 | 6,851 | 6,851 | - | - | Stock Option (right to buy) | |
| Bahram Valamehr | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2021 | 6,851 | 6,851 | - | - | Stock Option (right to buy) | |
| Bahram Valamehr | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2021 | 18,013 | 95,740 (0%) | 0% | 0 | Common stock | |
| Edward J. Dulac | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2021 | 6,851 | 6,851 | - | - | Stock Option (right to buy) | |
| Edward J. Dulac | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2021 | 18,013 | 58,013 (0%) | 0% | 0 | Common stock | |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 114.11 per share. | 19 Jan 2021 | 15,835 | 109,200 (0%) | 0% | 114.1 | 1,806,959 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Jan 2021 | 35,000 | 28,149 | - | - | Stock Option (right to buy) | |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 117.06 per share. | 19 Jan 2021 | 200 | 90,035 (0%) | 0% | 117.1 | 23,413 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 115.97 per share. | 19 Jan 2021 | 4,021 | 90,235 (0%) | 0% | 116.0 | 466,333 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 115.09 per share. | 19 Jan 2021 | 14,944 | 94,256 (0%) | 0% | 115.1 | 1,719,935 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.90 per share. | 19 Jan 2021 | 35,000 | 125,035 (0%) | 0% | 2.9 | 101,500 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 117.15 per share. | 08 Jan 2021 | 2,451 | 87,885 (0%) | 0% | 117.2 | 287,144 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 117.60 per share. | 08 Jan 2021 | 2,755 | 90,336 (0%) | 0% | 117.6 | 323,985 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 109.65 per share. | 08 Jan 2021 | 871 | 83,609 (0%) | 0% | 109.7 | 95,509 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 110.76 per share. | 08 Jan 2021 | 1,050 | 84,480 (0%) | 0% | 110.8 | 116,296 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 111.62 per share. | 08 Jan 2021 | 1,332 | 85,530 (0%) | 0% | 111.6 | 148,673 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 114.75 per share. | 08 Jan 2021 | 151 | 86,862 (0%) | 0% | 114.8 | 17,328 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 115.80 per share. | 08 Jan 2021 | 872 | 87,013 (0%) | 0% | 115.8 | 100,977 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 117.60 per share. | 08 Jan 2021 | 26,904 | 393,065 (0%) | 0% | 117.6 | 3,163,883 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 109.65 per share. | 08 Jan 2021 | 2,300 | 350,562 (0%) | 0% | 109.7 | 252,204 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 110.76 per share. | 08 Jan 2021 | 2,772 | 352,862 (0%) | 0% | 110.8 | 307,021 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 111.62 per share. | 08 Jan 2021 | 3,515 | 355,634 (0%) | 0% | 111.6 | 392,330 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 114.75 per share. | 08 Jan 2021 | 1,469 | 359,149 (0%) | 0% | 114.8 | 168,575 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 115.80 per share. | 08 Jan 2021 | 8,515 | 360,618 (0%) | 0% | 115.8 | 986,028 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 117.15 per share. | 08 Jan 2021 | 23,932 | 369,133 (0%) | 0% | 117.2 | 2,803,730 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 117.60 per share. | 08 Jan 2021 | 2,755 | 96,763 (0%) | 0% | 117.6 | 323,985 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 109.65 per share. | 08 Jan 2021 | 872 | 90,035 (0%) | 0% | 109.7 | 95,618 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 110.76 per share. | 08 Jan 2021 | 1,050 | 90,907 (0%) | 0% | 110.8 | 116,296 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 111.62 per share. | 08 Jan 2021 | 1,332 | 91,957 (0%) | 0% | 111.6 | 148,673 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 114.75 per share. | 08 Jan 2021 | 151 | 93,289 (0%) | 0% | 114.8 | 17,328 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 115.80 per share. | 08 Jan 2021 | 872 | 93,440 (0%) | 0% | 115.8 | 100,977 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 117.15 per share. | 08 Jan 2021 | 2,451 | 94,312 (0%) | 0% | 117.2 | 287,144 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 117.15 per share. | 08 Jan 2021 | 2,451 | 82,004 (0%) | 0% | 117.2 | 287,144 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 109.65 per share. | 08 Jan 2021 | 871 | 77,727 (0%) | 0% | 109.7 | 95,509 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 110.76 per share. | 08 Jan 2021 | 1,051 | 78,598 (0%) | 0% | 110.8 | 116,407 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 111.62 per share. | 08 Jan 2021 | 1,332 | 79,649 (0%) | 0% | 111.6 | 148,673 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 114.75 per share. | 08 Jan 2021 | 151 | 80,981 (0%) | 0% | 114.8 | 17,328 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 115.80 per share. | 08 Jan 2021 | 872 | 81,132 (0%) | 0% | 115.8 | 100,977 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 117.60 per share. | 08 Jan 2021 | 2,756 | 84,455 (0%) | 0% | 117.6 | 324,103 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 91.77 per share. | 17 Dec 2020 | 13,936 | 422,865 (0%) | 0% | 91.8 | 1,278,914 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 90.98 per share. | 17 Dec 2020 | 3,168 | 436,801 (0%) | 0% | 91.0 | 288,229 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.62 per share. | 17 Dec 2020 | 20,000 | 439,969 (0%) | 0% | 6.6 | 132,400 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2020 | 20,000 | 54,846 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 93.44 per share. | 17 Dec 2020 | 100 | 419,969 (0%) | 0% | 93.4 | 9,344 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 92.94 per share. | 17 Dec 2020 | 2,796 | 420,069 (0%) | 0% | 92.9 | 259,865 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 98.80 per share. | 14 Dec 2020 | 3,148 | 92,539 (0%) | 0% | 98.8 | 311,013 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 97.70 per share. | 14 Dec 2020 | 2,946 | 95,687 (0%) | 0% | 97.7 | 287,812 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 96.65 per share. | 14 Dec 2020 | 11,765 | 98,633 (0%) | 0% | 96.7 | 1,137,141 | Common stock |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.90 per share. | 14 Dec 2020 | 25,000 | 112,211 (0%) | 0% | 2.9 | 72,500 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 95.89 per share. | 14 Dec 2020 | 1,813 | 110,398 (0%) | 0% | 95.9 | 173,857 | Common stock |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2020 | 25,000 | 41,156 | - | - | Stock Option (right to buy) | |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 102.75 per share. | 14 Dec 2020 | 100 | 87,211 (0%) | 0% | 102.8 | 10,275 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 102.06 per share. | 14 Dec 2020 | 1,006 | 87,311 (0%) | 0% | 102.1 | 102,675 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 100.97 per share. | 14 Dec 2020 | 400 | 88,317 (0%) | 0% | 101.0 | 40,388 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 99.77 per share. | 14 Dec 2020 | 3,822 | 88,717 (0%) | 0% | 99.8 | 381,315 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 51.60 per share. | 16 Nov 2020 | 5,287 | 107,872 (0%) | 0% | 51.6 | 272,825 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 52.40 per share. | 16 Nov 2020 | 14,781 | 93,091 (0%) | 0% | 52.4 | 774,514 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.37 per share. | 16 Nov 2020 | 4,932 | 113,159 (0%) | 0% | 50.4 | 248,407 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 51.03 per share. | 12 Nov 2020 | 9,846 | 419,969 (0%) | 0% | 51.0 | 502,441 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Nov 2020 | 10,154 | 74,846 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Nov 2020 | 9,846 | 0 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Nov 2020 | 10,000 | 210,000 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Nov 2020 | 30,000 | 220,000 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 51.03 per share. | 12 Nov 2020 | 10,154 | 419,969 (0%) | 0% | 51.0 | 518,159 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.62 per share. | 12 Nov 2020 | 10,154 | 430,123 (0%) | 0% | 6.6 | 67,219 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.87 per share. | 12 Nov 2020 | 9,846 | 429,815 (0%) | 0% | 7.9 | 77,488 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 51.03 per share. | 12 Nov 2020 | 10,000 | 419,969 (0%) | 0% | 51.0 | 510,300 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 12 Nov 2020 | 10,000 | 429,969 (0%) | 0% | 2.7 | 27,300 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 54.47 per share. | 12 Nov 2020 | 1,864 | 419,969 (0%) | 0% | 54.5 | 101,534 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 53.98 per share. | 12 Nov 2020 | 10,846 | 421,833 (0%) | 0% | 54.0 | 585,505 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 52.66 per share. | 12 Nov 2020 | 2,088 | 432,679 (0%) | 0% | 52.7 | 109,961 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 51.61 per share. | 12 Nov 2020 | 15,202 | 434,767 (0%) | 0% | 51.6 | 784,524 | Common stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 12 Nov 2020 | 30,000 | 449,969 (0%) | 0% | 2.7 | 81,900 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 50.41 per share. | 04 Nov 2020 | 51,519 | 99,518 (0%) | 0% | 50.4 | 2,597,140 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 04 Nov 2020 | 51,519 | 151,037 (0%) | 0% | 2.7 | 140,647 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2020 | 10,000 | 63,149 | - | - | Stock Option (right to buy) | |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2020 | 9,282 | 25,000 | - | - | Stock Option (right to buy) | |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2020 | 51,519 | 34,282 | - | - | Stock Option (right to buy) | |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 51.15 per share. | 04 Nov 2020 | 2,600 | 99,518 (0%) | 0% | 51.2 | 132,999 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 50.55 per share. | 04 Nov 2020 | 16,682 | 102,118 (0%) | 0% | 50.5 | 843,253 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.90 per share. | 04 Nov 2020 | 10,000 | 118,800 (0%) | 0% | 2.9 | 29,000 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 04 Nov 2020 | 9,282 | 108,800 (0%) | 0% | 2.7 | 25,340 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 16 Oct 2020 | 29,199 | 128,717 (0%) | 0% | 2.7 | 79,713 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 50.25 per share. | 16 Oct 2020 | 29,199 | 99,518 (0%) | 0% | 50.2 | 1,467,212 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Oct 2020 | 29,199 | 85,801 | - | - | Stock Option (right to buy) | |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.73 per share. | 01 Oct 2020 | 35,000 | 134,518 (0%) | 0% | 2.7 | 95,550 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2020 | 35,000 | 115,000 | - | - | Stock Option (right to buy) | |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 41.95 per share. | 01 Oct 2020 | 6,983 | 99,518 (0%) | 0% | 41.9 | 292,929 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 41.09 per share. | 01 Oct 2020 | 6,260 | 106,501 (0%) | 0% | 41.1 | 257,234 | Common stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 40.26 per share. | 01 Oct 2020 | 21,757 | 112,761 (0%) | 0% | 40.3 | 875,902 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 36.11 per share. | 14 Sep 2020 | 17,887 | 123,804 (0%) | 0% | 36.1 | 645,909 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 37.12 per share. | 14 Sep 2020 | 5,713 | 118,091 (0%) | 0% | 37.1 | 212,074 | Common stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.40 per share. | 14 Sep 2020 | 1,400 | 141,691 (0%) | 0% | 35.4 | 49,557 | Common stock |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.90 per share. | 14 Sep 2020 | 21,924 | 112,211 (0%) | 0% | 2.9 | 63,580 | Common stock |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2020 | 21,924 | 66,156 | - | - | Stock Option (right to buy) | |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2020 | 3,076 | 0 | - | - | Stock Option (right to buy) | |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 37.49 per share. | 14 Sep 2020 | 600 | 87,211 (0%) | 0% | 37.5 | 22,494 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 36.93 per share. | 14 Sep 2020 | 7,016 | 87,811 (0%) | 0% | 36.9 | 259,085 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 36.03 per share. | 14 Sep 2020 | 16,784 | 94,827 (0%) | 0% | 36.0 | 604,654 | Common stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 34.65 per share. | 14 Sep 2020 | 600 | 111,611 (0%) | 0% | 34.7 | 20,792 | Common stock |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.69 per share. | 14 Sep 2020 | 3,076 | 90,287 (0%) | 0% | 1.7 | 5,198 | Common stock |
| Edward J. Dulac | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Aug 2020 | 160,000 | 160,000 | - | - | Stock Option (right to buy) | |
| Edward J. Dulac | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Aug 2020 | 40,000 | 40,000 (0%) | 0% | 0 | Common stock | |
| Robert M. Hershberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2020 | 16,000 | 16,000 | - | - | Stock Option (right to buy) | |
| Robert M. Hershberg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2020 | 24,000 | 24,000 | - | - | Stock Option (right to buy) | |
| William H. Rastetter | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2020 | 16,000 | 16,000 | - | - | Stock Option (right to buy) | |
| Robert S. Epstein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2020 | 16,000 | 16,000 | - | - | Stock Option (right to buy) | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2020 | 16,000 | 16,000 | - | - | Stock Option (right to buy) | |
| John D. Mendlein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2020 | 16,000 | 16,000 | - | - | Stock Option (right to buy) | |
| Shefali Agarwal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2020 | 16,000 | 16,000 | - | - | Stock Option (right to buy) | |
| Michael Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2020 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Karin Jooss | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2020 | 16,000 | 16,000 | - | - | Stock Option (right to buy) | |
| William H. Rastetter | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Mar 2020 | 28,461 | 0 | - | - | Stock Option (right to buy) | |
| William H. Rastetter | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.37 per share. | 30 Mar 2020 | 28,461 | 28,461 (0%) | - | 1.4 | 38,992 | Common stock |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.69 per share. | 03 Feb 2020 | 1,153 | 87,211 (0%) | 0% | 1.7 | 1,949 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2020 | 1,153 | 0 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 25.45 per share. | 30 Jan 2020 | 25,000 | 419,969 (0%) | 0% | 25.5 | 636,303 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2020 | 25,000 | 114,600 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.70 per share. | 30 Jan 2020 | 25,000 | 444,969 (0%) | 0% | 2.7 | 67,500 | Common Stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jan 2020 | 25,000 | 148,791 (0%) | 0% | 0 | Common Stock | |
| Daniel D. Shoemaker | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jan 2020 | 90,000 | 90,000 | - | - | Stock Option (right to buy) | |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 20.70 per share. | 08 Jan 2020 | 5,700 | 143,091 (0%) | 0% | 20.7 | 117,986 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jan 2020 | 219,000 | 219,000 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jan 2020 | 66,000 | 419,969 (0%) | 0% | 0 | Common Stock | |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 20.72 per share. | 08 Jan 2020 | 5,700 | 99,518 (0%) | 0% | 20.7 | 118,085 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jan 2020 | 90,000 | 90,000 | - | - | Stock Option (right to buy) | |
| Cindy Tahl | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jan 2020 | 25,000 | 105,218 (0%) | 0% | 0 | Common Stock | |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 20.69 per share. | 08 Jan 2020 | 5,700 | 86,058 (0%) | 0% | 20.7 | 117,947 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jan 2020 | 25,000 | 91,758 (0%) | 0% | 0 | Common Stock | |
| Bahram Valamehr | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jan 2020 | 90,000 | 90,000 | - | - | Stock Option (right to buy) | |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 20.34 per share. | 30 Dec 2019 | 100 | 123,791 (0%) | 0% | 20.3 | 2,034 | Common Stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 19.49 per share. | 30 Dec 2019 | 24,900 | 123,891 (0%) | 0% | 19.5 | 485,393 | Common Stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.90 per share. | 30 Dec 2019 | 25,000 | 148,791 (0%) | 0% | 2.9 | 72,500 | Common Stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Dec 2019 | 25,000 | 98,800 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.70 per share. | 19 Dec 2019 | 25,000 | 378,969 (0%) | 0% | 2.7 | 67,500 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.70 per share. | 19 Dec 2019 | 25,000 | 378,969 (0%) | 0% | 2.7 | 67,500 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.08 per share. | 19 Dec 2019 | 25,000 | 353,969 (0%) | 0% | 20.1 | 501,898 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Dec 2019 | 25,000 | 139,600 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Dec 2019 | 25,000 | 164,600 | - | - | Stock Option (right to buy) | |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.17 per share. | 19 Dec 2019 | 25,000 | 353,969 (0%) | 0% | 20.2 | 504,158 | Common Stock |
| Daniel D. Shoemaker | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 14.29 per share. | 15 Oct 2019 | 11,800 | 123,791 (0%) | 0% | 14.3 | 168,593 | Common Stock |
| J. Scott Wolchko | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 14.44 per share. | 15 Oct 2019 | 21,017 | 353,969 (0%) | 0% | 14.4 | 303,458 | Common Stock |
| Cindy Tahl | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 14.24 per share. | 15 Oct 2019 | 10,200 | 80,218 (0%) | 0% | 14.2 | 145,292 | Common Stock |
| Bahram Valamehr | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 14.18 per share. | 15 Oct 2019 | 6,200 | 66,758 (0%) | 0% | 14.2 | 87,891 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.53 per share. | 31 Jul 2019 | 29,782 | 1,099,772 (1%) | 0% | 22.5 | 670,971 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.53 per share. | 31 Jul 2019 | 299 | 11,034 (0%) | 0% | 22.5 | 6,736 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.53 per share. | 31 Jul 2019 | 302 | 11,333 (0%) | 0% | 22.5 | 6,805 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.53 per share. | 31 Jul 2019 | 204 | 7,539 (0%) | 0% | 22.5 | 4,596 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.53 per share. | 31 Jul 2019 | 206 | 7,743 (0%) | 0% | 22.5 | 4,642 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.53 per share. | 31 Jul 2019 | 581 | 21,438 (0%) | 0% | 22.5 | 13,090 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.53 per share. | 31 Jul 2019 | 586 | 22,019 (0%) | 0% | 22.5 | 13,205 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.53 per share. | 31 Jul 2019 | 30,045 | 1,129,554 (1%) | 0% | 22.5 | 677,022 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.51 per share. | 26 Jul 2019 | 596 | 7,949 (0%) | 0% | 22.5 | 13,414 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.51 per share. | 26 Jul 2019 | 873 | 11,635 (0%) | 0% | 22.5 | 19,649 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.67 per share. | 26 Jul 2019 | 3 | 12,508 (0%) | 0% | 22.7 | 68 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.50 per share. | 26 Jul 2019 | 270 | 12,511 (0%) | 0% | 22.5 | 6,075 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.67 per share. | 26 Jul 2019 | 3 | 8,545 (0%) | 0% | 22.7 | 68 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.50 per share. | 26 Jul 2019 | 184 | 8,548 (0%) | 0% | 22.5 | 4,140 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.51 per share. | 26 Jul 2019 | 1,696 | 22,605 (0%) | 0% | 22.5 | 38,172 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.50 per share. | 26 Jul 2019 | 6 | 24,301 (0%) | 0% | 22.5 | 135 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.50 per share. | 26 Jul 2019 | 523 | 24,307 (0%) | 0% | 22.5 | 11,768 | Common Stock |
| Amir H. Nashat | Director | Sale of securities on an exchange or to another person at price $ 22.51 per share. | 26 Jul 2019 | 87,010 | 1,159,599 (1%) | 0% | 22.5 | 1,958,325 | Common Stock |