788.7K XNAS Volume
XNAS 17 Mar, 2025 12:54 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 38.80 per share. | 03 Mar 2025 | 10,000 | 341,028 (0%) | 0% | 38.8 | 388,000 | Common Stock |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.50 per share. | 28 Feb 2025 | 15,874 | 365,373 (0%) | 0% | 20.5 | 325,417 | Common Stock |
| Jack L. Wyszomierski | Director | Sale of securities on an exchange or to another person at price $ 37.80 per share. | 28 Feb 2025 | 8,768 | 356,605 (0%) | 0% | 37.8 | 331,430 | Common Stock |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2025 | 15,874 | 0 | - | - | Option (right to buy) | |
| Julie Anne Smith | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 23,347 | 19,294 | - | - | Option (right to buy) | |
| Julie Anne Smith | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.50 per share. | 27 Feb 2025 | 31,167 | 41,945 (0%) | 0% | 20.5 | 638,924 | Common Stock |
| Julie Anne Smith | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.77 per share. | 27 Feb 2025 | 23,347 | 65,292 (0%) | 0% | 19.8 | 461,570 | Common Stock |
| Julie Anne Smith | Director | Sale of securities on an exchange or to another person at price $ 37.62 per share. | 27 Feb 2025 | 19,294 | 10,778 (0%) | 0% | 37.6 | 725,840 | Common Stock |
| Julie Anne Smith | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 19,294 | 0 | - | - | Option (right to buy) | |
| Julie Anne Smith | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 31,167 | 0 | - | - | Option (right to buy) | |
| Julie Anne Smith | Director | Sale of securities on an exchange or to another person at price $ 38.13 per share. | 27 Feb 2025 | 54,514 | 10,778 (0%) | 0% | 38.1 | 2,078,619 | Common Stock |
| Julie Anne Smith | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.77 per share. | 27 Feb 2025 | 19,294 | 30,072 (0%) | 0% | 19.8 | 381,442 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 184,909 | 1,033,290 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 52,192 | 597,608 (0%) | 0% | 0 | Common Stock | |
| Christopher J. Senner | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 59,648 | 839,255 (0%) | 0% | 0 | Common Stock | |
| Amy C. Peterson | EVP Prod Dev & Med Aff & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 52,192 | 347,089 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 47,718 | 351,028 (0%) | 0% | 0 | Common Stock | |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2025 | 49,209 | 561,117 (0%) | 0% | 0 | Common Stock | |
| Bob Oliver | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Feb 2025 | 15,147 | 21,206 | - | - | Option (right to buy) | |
| Bob Oliver | Director | Sale of securities on an exchange or to another person at price $ 37.25 per share. | 25 Feb 2025 | 18,647 | 33,514 (0%) | 0% | 37.3 | 694,601 | Common Stock |
| Bob Oliver | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.28 per share. | 25 Feb 2025 | 15,147 | 52,161 (0%) | 0% | 19.3 | 292,034 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Feb 2025 | 177,985 | 848,381 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Feb 2025 | 177,985 | 1,764,985 (0%) | 0% | 0 | Common Stock | |
| Christopher J. Senner | EVP and CFO | Sale of securities on an exchange or to another person at price $ 36.14 per share. | 24 Feb 2025 | 29,314 | 779,607 (0%) | 0% | 36.1 | 1,059,408 | Common Stock |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.80 per share. | 24 Feb 2025 | 29,314 | 808,921 (0%) | 0% | 18.8 | 551,103 | Common Stock |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2025 | 29,314 | 100,000 | - | - | Option (right to buy) | |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 36.98 per share. | 24 Feb 2025 | 52,636 | 303,310 (0%) | 0% | 37.0 | 1,946,479 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Sale of securities on an exchange or to another person at price $ 36.75 per share. | 24 Feb 2025 | 26,987 | 511,908 (0%) | 0% | 36.7 | 991,772 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.00 per share. | 15 Feb 2025 | 63,570 | 1,026,366 (0%) | 0% | 35 | 2,224,950 | Common Stock |
| Jeffrey J. Hessekiel | EVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.00 per share. | 15 Feb 2025 | 18,134 | 545,416 (0%) | 0% | 35 | 634,690 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.00 per share. | 15 Feb 2025 | 21,591 | 779,607 (0%) | 0% | 35 | 755,685 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.00 per share. | 15 Feb 2025 | 18,906 | 355,946 (0%) | 0% | 35 | 661,710 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.00 per share. | 15 Feb 2025 | 16,053 | 551,590 (0%) | 0% | 35 | 561,855 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.00 per share. | 15 Feb 2025 | 12,695 | 538,895 (0%) | 0% | 35 | 444,325 | Common Stock |
| George H. Poste | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.50 per share. | 14 Feb 2025 | 15,874 | 184,894 (0%) | 0% | 20.5 | 325,417 | Common Stock |
| George H. Poste | Director | Sale of securities on an exchange or to another person at price $ 34.74 per share. | 14 Feb 2025 | 15,874 | 169,020 (0%) | 0% | 34.7 | 551,463 | Common Stock |
| George H. Poste | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2025 | 15,874 | 0 | - | - | Option (right to buy) | |
| Mary C. Beckerle | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.24 per share. | 14 Feb 2025 | 8,354 | 42,616 (0%) | 0% | 23.2 | 194,147 | Common Stock |
| Mary C. Beckerle | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2025 | 8,354 | 22,494 | - | - | Option (right to buy) | |
| Mary C. Beckerle | Director | Sale of securities on an exchange or to another person at price $ 34.90 per share. | 14 Feb 2025 | 3,856 | 30,406 (0%) | 0% | 34.9 | 134,574 | Common Stock |
| Mary C. Beckerle | Director | Sale of securities on an exchange or to another person at price $ 34.87 per share. | 14 Feb 2025 | 8,354 | 34,262 (0%) | 0% | 34.9 | 291,304 | Common Stock |
| Maria C. Freire | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.50 per share. | 14 Feb 2025 | 15,874 | 106,881 (0%) | 0% | 20.5 | 325,417 | Common Stock |
| Maria C. Freire | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2025 | 28,240 | 0 | - | - | Option (right to buy) | |
| Maria C. Freire | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2025 | 15,874 | 0 | - | - | Option (right to buy) | |
| Maria C. Freire | Director | Sale of securities on an exchange or to another person at price $ 34.94 per share. | 14 Feb 2025 | 44,114 | 91,007 (0%) | 0% | 34.9 | 1,541,343 | Common Stock |
| Maria C. Freire | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.10 per share. | 14 Feb 2025 | 28,240 | 135,121 (0%) | 0% | 22.1 | 624,104 | Common Stock |
| Sue Gail Eckhardt | Director | Sale of securities on an exchange or to another person at price $ 35.04 per share. | 14 Feb 2025 | 3,856 | 30,406 (0%) | 0% | 35.0 | 135,114 | Common Stock |
| Sue Gail Eckhardt | Director | Sale of securities on an exchange or to another person at price $ 35.01 per share. | 14 Feb 2025 | 7,712 | 34,262 (0%) | 0% | 35.0 | 269,997 | Common Stock |
| Sue Gail Eckhardt | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.24 per share. | 14 Feb 2025 | 7,712 | 41,974 (0%) | 0% | 23.2 | 179,227 | Common Stock |
| Sue Gail Eckhardt | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2025 | 7,712 | 23,136 | - | - | Option (right to buy) | |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.27 per share. | 16 Jan 2025 | 120,244 | 1,089,936 (0%) | 0% | 37.3 | 4,481,494 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 473,226 | 1,210,180 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 118,780 | 589,839 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.27 per share. | 16 Jan 2025 | 26,289 | 563,550 (0%) | 0% | 37.3 | 979,791 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.27 per share. | 16 Jan 2025 | 35,949 | 801,198 (0%) | 0% | 37.3 | 1,339,819 | Common Stock |
| Christopher J. Senner | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 132,973 | 837,147 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 123,750 | 402,415 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.27 per share. | 16 Jan 2025 | 27,563 | 374,852 (0%) | 0% | 37.3 | 1,027,273 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jan 2025 | 104,106 | 590,213 (0%) | 0% | 0 | Common Stock | |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 37.27 per share. | 16 Jan 2025 | 22,570 | 567,643 (0%) | 0% | 37.3 | 841,184 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 20 Dec 2024 | 179,788 | 736,954 (0%) | 0% | 0 | Common Stock | |
| M. Michael Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 20 Dec 2024 | 179,788 | 1,587,000 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.80 per share. | 27 Nov 2024 | 129,314 | 644,967 (0%) | 0% | 18.8 | 2,431,103 | Common Stock |
| Jeffrey J. Hessekiel | EVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Nov 2024 | 129,314 | 0 | - | - | Option (right to buy) | |
| Jeffrey J. Hessekiel | EVP & General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Nov 2024 | 15,000 | 471,059 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP & General Counsel | Sale of securities on an exchange or to another person at price $ 36.67 per share. | 27 Nov 2024 | 60,000 | 486,059 (0%) | 0% | 36.7 | 2,200,200 | Common Stock |
| Jeffrey J. Hessekiel | EVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.93 per share. | 27 Nov 2024 | 98,908 | 546,059 (0%) | 0% | 35.9 | 3,553,764 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 35.27 per share. | 22 Nov 2024 | 10,000 | 278,665 (0%) | 0% | 35.3 | 352,700 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.05 per share. | 15 Nov 2024 | 47,642 | 916,742 (0%) | 0% | 35.0 | 1,669,852 | Common Stock |
| Jeffrey J. Hessekiel | EVP & General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.05 per share. | 15 Nov 2024 | 14,672 | 515,653 (0%) | 0% | 35.1 | 514,254 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.05 per share. | 15 Nov 2024 | 17,506 | 704,174 (0%) | 0% | 35.0 | 613,585 | Common Stock |
| Amy C. Peterson | EVP Prod Dev & Med Aff & CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.05 per share. | 15 Nov 2024 | 27,224 | 294,897 (0%) | 0% | 35.0 | 954,201 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 34.31 per share. | 15 Nov 2024 | 22,207 | 308,046 (0%) | 0% | 34.3 | 761,922 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.05 per share. | 15 Nov 2024 | 14,672 | 330,253 (0%) | 0% | 35.1 | 514,254 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 34.41 per share. | 15 Nov 2024 | 19,381 | 288,665 (0%) | 0% | 34.4 | 666,900 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 35.05 per share. | 15 Nov 2024 | 12,838 | 486,107 (0%) | 0% | 35.1 | 449,972 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 05 Nov 2024 | 96,986 | 498,945 (0%) | 0% | 35 | 3,394,510 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Nov 2024 | 96,986 | 0 | - | - | Option (right to buy) | |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.80 per share. | 05 Nov 2024 | 96,986 | 595,931 (0%) | 0% | 18.8 | 1,823,337 | Common Stock |
| George H. Poste | Director | Sale of securities on an exchange or to another person at price $ 34.00 per share. | 01 Nov 2024 | 30,000 | 169,020 (0%) | 0% | 34 | 1,020,000 | Common Stock |
| Jeffrey J. Hessekiel | EVP & General Counsel | Sale of securities on an exchange or to another person at price $ 34.13 per share. | 01 Nov 2024 | 50,000 | 530,325 (0%) | 0% | 34.1 | 1,706,500 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Oct 2024 | 46,000 | 1,407,212 (0%) | 0% | 0 | Common Stock | |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Sale of securities on an exchange or to another person at price $ 31.40 per share. | 30 Oct 2024 | 1,162 | 498,945 (0%) | 0% | 31.4 | 36,487 | Common Stock |
| Jeffrey J. Hessekiel | EVP & General Counsel | Sale of securities on an exchange or to another person at price $ 28.39 per share. | 28 Oct 2024 | 25,000 | 580,325 (0%) | 0% | 28.4 | 709,750 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.41 per share. | 02 Oct 2024 | 100,000 | 441,036 (0%) | 0% | 24.4 | 2,441,000 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.50 per share. | 02 Oct 2024 | 96,111 | 344,925 (0%) | 0% | 26.5 | 2,546,942 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Oct 2024 | 100,000 | 0 | - | - | Option (right to buy) | |
| Michael M. Morrissey | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.41 per share. | 01 Oct 2024 | 480,000 | 1,444,384 (0%) | 0% | 24.4 | 11,716,800 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.30 per share. | 01 Oct 2024 | 463,702 | 980,682 (0%) | 0% | 26.3 | 12,195,363 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 480,000 | 0 | - | - | Option (right to buy) | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 01 Oct 2024 | 16,298 | 1,453,212 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 01 Oct 2024 | 16,298 | 964,384 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP & General Counsel | Sale of securities on an exchange or to another person at price $ 26.38 per share. | 23 Sep 2024 | 25,000 | 605,325 (0%) | 0% | 26.4 | 659,500 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2024 | 20,000 | 0 | - | - | Option (right to buy) | |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 25.79 per share. | 26 Aug 2024 | 20,000 | 630,325 (0%) | 0% | 25.8 | 515,800 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.41 per share. | 26 Aug 2024 | 20,000 | 650,325 (0%) | 0% | 24.4 | 488,200 | Common Stock |
| Maria C. Freire | Director | Sale of securities on an exchange or to another person at price $ 26.56 per share. | 14 Aug 2024 | 8,250 | 91,007 (0%) | 0% | 26.6 | 219,120 | Common Stock |
| Julie Anne Smith | Director | Other type of transaction at price $ 0.00 per share. | 13 Aug 2024 | 4,682 | 10,778 (0%) | 0% | 0 | Common Stock | |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Sale of securities on an exchange or to another person at price $ 27.06 per share. | 12 Aug 2024 | 20,883 | 500,107 (0%) | 0% | 27.1 | 565,094 | Common Stock |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.41 per share. | 09 Aug 2024 | 125,000 | 846,680 (0%) | 0% | 24.4 | 3,051,250 | Common Stock |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Aug 2024 | 125,000 | 0 | - | - | Option (right to buy) | |
| Christopher J. Senner | EVP and CFO | Sale of securities on an exchange or to another person at price $ 27.19 per share. | 09 Aug 2024 | 125,000 | 721,680 (0%) | 0% | 27.2 | 3,398,750 | Common Stock |
| George H. Poste | Director | Sale of securities on an exchange or to another person at price $ 26.89 per share. | 08 Aug 2024 | 33,725 | 199,020 (0%) | 0% | 26.9 | 906,865 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.41 per share. | 07 Aug 2024 | 80,000 | 710,325 (0%) | 0% | 24.4 | 1,952,800 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2024 | 80,000 | 20,000 | - | - | Option (right to buy) | |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 25.97 per share. | 07 Aug 2024 | 80,000 | 630,325 (0%) | 0% | 26.0 | 2,077,600 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 25.50 per share. | 07 Aug 2024 | 14,000 | 341,036 (0%) | 0% | 25.5 | 357,000 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.41 per share. | 07 Aug 2024 | 95,000 | 615,990 (0%) | 0% | 24.4 | 2,318,950 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2024 | 95,000 | 0 | - | - | Option (right to buy) | |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 07 Aug 2024 | 95,000 | 520,990 (0%) | 0% | 25 | 2,375,000 | Common Stock |
| Jack L. Wyszomierski | Director | Sale of securities on an exchange or to another person at price $ 22.00 per share. | 04 Jun 2024 | 8,287 | 349,499 (0%) | 0% | 22 | 182,314 | Common Stock |
| George H. Poste | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 18,838 | 232,745 (0%) | 0% | 0 | Common Stock | |
| Jack L. Wyszomierski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 18,838 | 357,786 (0%) | 0% | 0 | Common Stock | |
| Stelios Papadopoulos | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 18,838 | 1,279,416 (0%) | 0% | 0 | Common Stock | |
| Mary C. Beckerle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 18,838 | 34,262 (0%) | 0% | 0 | Common Stock | |
| Maria C. Freire | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 18,838 | 99,257 (0%) | 0% | 0 | Common Stock | |
| Julie Anne Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 20,030 | 20,030 | - | - | Option (right to buy) | |
| Julie Anne Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 10,015 | 15,460 (0%) | 0% | 0 | Common Stock | |
| Bob Oliver | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 18,838 | 37,014 (0%) | 0% | 0 | Common Stock | |
| Tomas J. Heyman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 18,838 | 37,014 (0%) | 0% | 0 | Common Stock | |
| Sue Gail Eckhardt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2024 | 18,838 | 34,262 (0%) | 0% | 0 | Common Stock | |
| George H. Poste | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 May 2024 | 11,686 | 0 | - | - | Option (right to buy) | |
| George H. Poste | Director | Sale of securities on an exchange or to another person at price $ 20.96 per share. | 21 May 2024 | 11,686 | 213,907 (0%) | 0% | 21.0 | 244,939 | Common Stock |
| George H. Poste | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.57 per share. | 21 May 2024 | 11,686 | 225,593 (0%) | 0% | 19.6 | 228,695 | Common Stock |
| Julie Anne Smith | Director | Sale of securities on an exchange or to another person at price $ 21.12 per share. | 21 May 2024 | 27,280 | 5,445 (0%) | 0% | 21.1 | 576,154 | Common Stock |
| Stelios Papadopoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.57 per share. | 20 May 2024 | 11,686 | 1,272,015 (0%) | 0% | 19.6 | 228,695 | Common Stock |
| Stelios Papadopoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 May 2024 | 11,686 | 0 | - | - | Option (right to buy) | |
| Stelios Papadopoulos | Director | Sale of securities on an exchange or to another person at price $ 21.00 per share. | 20 May 2024 | 11,437 | 1,260,578 (0%) | 0% | 21 | 240,177 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 34,262 | 1,004,065 (0%) | 0% | 21.0 | 719,159 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 39,681 | 964,384 (0%) | 0% | 21.0 | 832,904 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 10,101 | 630,325 (0%) | 0% | 21.0 | 212,020 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 7,240 | 649,026 (0%) | 0% | 21.0 | 151,968 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 8,600 | 640,426 (0%) | 0% | 21.0 | 180,514 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 11,478 | 721,680 (0%) | 0% | 21.0 | 240,923 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 10,211 | 733,158 (0%) | 0% | 21.0 | 214,329 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 8,621 | 743,369 (0%) | 0% | 21.0 | 180,955 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 8,960 | 365,137 (0%) | 0% | 21.0 | 188,070 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 10,101 | 355,036 (0%) | 0% | 21.0 | 212,020 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 4,435 | 381,645 (0%) | 0% | 21.0 | 93,091 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 7,548 | 374,097 (0%) | 0% | 21.0 | 158,433 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 7,538 | 529,648 (0%) | 0% | 21.0 | 158,223 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 8,658 | 520,990 (0%) | 0% | 21.0 | 181,731 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.99 per share. | 15 May 2024 | 6,409 | 537,186 (0%) | 0% | 21.0 | 134,525 | Common Stock |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.57 per share. | 13 May 2024 | 11,686 | 349,871 (0%) | 0% | 19.6 | 228,695 | Common Stock |
| Jack L. Wyszomierski | Director | Sale of securities on an exchange or to another person at price $ 21.37 per share. | 13 May 2024 | 10,923 | 338,948 (0%) | 0% | 21.4 | 233,425 | Common Stock |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 May 2024 | 11,686 | 0 | - | - | Option (right to buy) | |
| Alan M. Garber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2024 | 23,491 | 0 | - | - | Option (right to buy) | |
| Alan M. Garber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.57 per share. | 21 Mar 2024 | 23,491 | 54,908 (0%) | 0% | 19.6 | 459,719 | Common Stock |
| Alan M. Garber | Director | Sale of securities on an exchange or to another person at price $ 24.01 per share. | 21 Mar 2024 | 19,205 | 35,703 (0%) | 0% | 24.0 | 461,112 | Common Stock |
| J. Senner Christopher | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 82,121 | 751,990 (0%) | 0% | 0 | Common Stock | |
| Amy C. Peterson | EVP Prod Dev & Med Aff & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 82,121 | 322,121 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 63,350 | 431,886 (0%) | 0% | 0 | Common Stock | |
| Dana Aftab T. | CSO/EVP Disc & Trans Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 63,350 | 542,381 (0%) | 0% | 0 | Common Stock | |
| Morrissey Michael M. | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 241,670 | 1,038,327 (0%) | 0% | 0 | Common Stock | |
| Jeffrey Hessekiel J. | EVP, General Counsel & Sec | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 63,350 | 655,052 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 21.45 per share. | 23 Feb 2024 | 47,020 | 384,866 (0%) | 0% | 21.5 | 1,008,579 | Common Stock |
| Aftab T. Dana | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.39 per share. | 15 Feb 2024 | 10,630 | 479,031 (0%) | 0% | 20.4 | 216,746 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.86 per share. | 11 Jan 2024 | 13,061 | 591,702 (0%) | 0% | 22.9 | 298,574 | Common Stock |
| Patrick Haley J. | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.86 per share. | 11 Jan 2024 | 13,613 | 368,536 (0%) | 0% | 22.9 | 311,193 | Common Stock |
| M. Morrissey Michael | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2024 | 250,374 | 860,374 (0%) | 0% | 0 | Common Stock | |
| J. Christopher Senner | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2024 | 80,186 | 691,731 (0%) | 0% | 0 | Common Stock | |
| Hessekiel Jeffrey J. | EVP, General Counsel & Sec | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2024 | 71,418 | 604,763 (0%) | 0% | 0 | Common Stock | |
| Dana Aftab T. | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.86 per share. | 11 Jan 2024 | 11,606 | 489,661 (0%) | 0% | 22.9 | 265,313 | Common Stock |
| T. Aftab Dana | CSO/EVP Disc & Trans Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2024 | 63,224 | 501,267 (0%) | 0% | 0 | Common Stock | |
| Haley Patrick J. | EVP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Jan 2024 | 74,462 | 382,149 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.86 per share. | 11 Jan 2024 | 63,717 | 796,657 (0%) | 0% | 22.9 | 1,456,571 | Common Stock |
| J. Christopher Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.86 per share. | 11 Jan 2024 | 21,862 | 669,869 (0%) | 0% | 22.9 | 499,765 | Common Stock |
| Eckhardt Sue Gail | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2024 | 15,424 | 15,424 (0%) | 0% | 0 | Common Stock | |
| Mary C. Beckerle | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2024 | 15,424 | 15,424 (0%) | 0% | 0 | Common Stock | |
| Mary Beckerle C. | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2024 | 30,848 | 30,848 | - | - | Option (right to buy) | |
| Eckhardt Gail Sue | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2024 | 30,848 | 30,848 | - | - | Option (right to buy) | |
| J. Hessekiel Jeffrey | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 23.01 per share. | 13 Dec 2023 | 25,000 | 533,345 (0%) | 0% | 23.0 | 575,250 | Common Stock |
| J. Haley Patrick | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2023 | 50,000 | 0 | - | - | Option (right to buy) | |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 23.35 per share. | 12 Dec 2023 | 50,000 | 307,687 (0%) | 0% | 23.4 | 1,167,500 | Common Stock |
| Haley Patrick J. | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.29 per share. | 12 Dec 2023 | 50,000 | 357,687 (0%) | 0% | 16.3 | 814,500 | Common Stock |
| J. Haley Patrick | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 22.50 per share. | 12 Dec 2023 | 14,149 | 307,687 (0%) | 0% | 22.5 | 318,353 | Common Stock |
| Hessekiel J. Jeffrey | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 22.01 per share. | 30 Nov 2023 | 25,000 | 583,345 (0%) | 0% | 22.0 | 550,250 | Common Stock |
| J. Jeffrey Hessekiel | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 22.06 per share. | 30 Nov 2023 | 25,000 | 558,345 (0%) | 0% | 22.1 | 551,500 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 15.31 per share. | 28 Aug 2023 | 360,000 | 945,496 (0%) | 0% | 15.3 | 5,511,600 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.18 per share. | 28 Aug 2023 | 303,779 | 641,717 (0%) | 0% | 22.2 | 6,737,818 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Aug 2023 | 360,000 | 0 | - | - | Option (right to buy) | |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 15 Aug 2023 | 23,304 | 585,496 (0%) | 0% | 21.5 | 501,269 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 15 Aug 2023 | 7,177 | 564,799 (0%) | 0% | 21.5 | 154,377 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 15 Aug 2023 | 8,074 | 563,557 (0%) | 0% | 21.5 | 173,672 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 15 Aug 2023 | 7,177 | 278,290 (0%) | 0% | 21.5 | 154,377 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.51 per share. | 15 Aug 2023 | 6,280 | 404,543 (0%) | 0% | 21.5 | 135,083 | Common Stock |
| Christopher J. Senner | EVP and CFO | Sale of securities on an exchange or to another person at price $ 20.51 per share. | 03 Aug 2023 | 60,000 | 571,631 (0%) | 0% | 20.5 | 1,230,600 | Common Stock |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2023 | 60,000 | 0 | - | - | Option (right to buy) | |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Aug 2023 | 60,000 | 60,000 | - | - | Option (right to buy) | |
| Christopher J. Senner | EVP and CFO | Sale of securities on an exchange or to another person at price $ 20.68 per share. | 03 Aug 2023 | 60,000 | 571,631 (0%) | 0% | 20.7 | 1,240,800 | Common Stock |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.74 per share. | 03 Aug 2023 | 60,000 | 631,631 (0%) | 0% | 14.7 | 884,400 | Common Stock |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.74 per share. | 03 Aug 2023 | 60,000 | 631,631 (0%) | 0% | 14.7 | 884,400 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 20.67 per share. | 03 Aug 2023 | 30,553 | 285,467 (0%) | 0% | 20.7 | 631,531 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.74 per share. | 01 Aug 2023 | 55,710 | 627,686 (0%) | 0% | 14.7 | 821,165 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2023 | 55,710 | 0 | - | - | Option (right to buy) | |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 19.63 per share. | 01 Aug 2023 | 55,710 | 571,976 (0%) | 0% | 19.6 | 1,093,587 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.18 per share. | 15 May 2023 | 33,518 | 608,800 (0%) | 0% | 19.2 | 642,875 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.18 per share. | 15 May 2023 | 4,940 | 579,003 (0%) | 0% | 19.2 | 94,749 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.18 per share. | 15 May 2023 | 7,027 | 571,976 (0%) | 0% | 19.2 | 134,778 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.18 per share. | 15 May 2023 | 10,002 | 571,631 (0%) | 0% | 19.2 | 191,838 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.18 per share. | 15 May 2023 | 8,444 | 581,633 (0%) | 0% | 19.2 | 161,956 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.18 per share. | 15 May 2023 | 8,765 | 316,020 (0%) | 0% | 19.2 | 168,113 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.18 per share. | 15 May 2023 | 3,026 | 331,059 (0%) | 0% | 19.2 | 58,039 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.18 per share. | 15 May 2023 | 6,274 | 324,785 (0%) | 0% | 19.2 | 120,335 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.18 per share. | 15 May 2023 | 4,373 | 416,938 (0%) | 0% | 19.2 | 83,874 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.18 per share. | 15 May 2023 | 6,115 | 410,823 (0%) | 0% | 19.2 | 117,286 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Apr 2023 | 313,185 | 642,318 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 20.01 per share. | 03 Apr 2023 | 38,930 | 582,435 (0%) | 0% | 20.0 | 778,989 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Apr 2023 | 79,719 | 607,435 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.74 per share. | 03 Apr 2023 | 13,930 | 621,365 (0%) | 0% | 14.7 | 205,328 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Apr 2023 | 13,930 | 55,710 | - | - | Option (right to buy) | |
| Christopher J. Senner | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Apr 2023 | 85,414 | 590,077 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Apr 2023 | 79,719 | 332,577 (0%) | 0% | 0 | Common Stock | |
| Vicki L. Goodman | EVP, Prod Dev & Med Aff &CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Apr 2023 | 82,566 | 307,654 (0%) | 0% | 0 | Common Stock | |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Apr 2023 | 68,331 | 419,803 (0%) | 0% | 0 | Common Stock | |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 40,000 | 0 | - | - | Option (right to buy) | |
| Jack L. Wyszomierski | Director | Sale of securities on an exchange or to another person at price $ 16.61 per share. | 10 Mar 2023 | 15,300 | 317,467 (0%) | 0% | 16.6 | 254,133 | Common Stock |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 10 Mar 2023 | 40,000 | 332,767 (0%) | 0% | 6.3 | 252,000 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 17.13 per share. | 01 Mar 2023 | 77,860 | 527,716 (0%) | 0% | 17.1 | 1,333,742 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2023 | 27,860 | 69,640 | - | - | Option (right to buy) | |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.74 per share. | 01 Mar 2023 | 27,860 | 605,576 (0%) | 0% | 14.7 | 410,656 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.70 per share. | 27 Feb 2023 | 10 | 351,482 (0%) | 0% | 14.7 | 147 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2023 | 82,490 | 0 | - | - | Option (right to buy) | |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2023 | 10 | 82,490 | - | - | Option (right to buy) | |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Sale of securities on an exchange or to another person at price $ 17.50 per share. | 27 Feb 2023 | 82,490 | 351,472 (0%) | 0% | 17.5 | 1,443,575 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.74 per share. | 27 Feb 2023 | 82,490 | 433,962 (0%) | 0% | 14.7 | 1,215,903 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Sale of securities on an exchange or to another person at price $ 17.50 per share. | 27 Feb 2023 | 10 | 351,472 (0%) | 0% | 17.5 | 175 | Common Stock |
| Alan M. Garber | Director | Sale of securities on an exchange or to another person at price $ 17.49 per share. | 21 Feb 2023 | 40,000 | 31,417 (0%) | 0% | 17.5 | 699,600 | Common Stock |
| Alan M. Garber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Feb 2023 | 40,000 | 0 | - | - | Option (right to buy) | |
| Alan M. Garber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 21 Feb 2023 | 40,000 | 71,417 (0%) | 0% | 6.3 | 252,000 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.08 per share. | 15 Feb 2023 | 11,522 | 329,133 (0%) | 0% | 18.1 | 208,318 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.08 per share. | 15 Feb 2023 | 1,929 | 577,716 (0%) | 0% | 18.1 | 34,876 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.08 per share. | 15 Feb 2023 | 5,278 | 504,663 (0%) | 0% | 18.1 | 95,426 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.08 per share. | 15 Feb 2023 | 1,556 | 252,858 (0%) | 0% | 18.1 | 28,132 | Common Stock |
| Vicki L. Goodman | EVP, Prod Dev & Med Aff &CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.08 per share. | 15 Feb 2023 | 17,299 | 225,088 (0%) | 0% | 18.1 | 312,766 | Common Stock |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.08 per share. | 15 Feb 2023 | 1,529 | 351,472 (0%) | 0% | 18.1 | 27,644 | Common Stock |
| Carl B. Feldbaum | Director | Sale of securities on an exchange or to another person at price $ 17.78 per share. | 09 Feb 2023 | 40,000 | 18,701 (0%) | 0% | 17.8 | 711,200 | Common Stock |
| Carl B. Feldbaum | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 09 Feb 2023 | 40,000 | 58,701 (0%) | 0% | 6.3 | 252,000 | Common Stock |
| Carl B. Feldbaum | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Feb 2023 | 40,000 | 0 | - | - | Option (right to buy) | |
| Patrick J. Haley | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.20 per share. | 06 Feb 2023 | 25,000 | 279,414 (0%) | 0% | 4.2 | 105,000 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2023 | 25,000 | 0 | - | - | Option (right to buy) | |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 17.37 per share. | 06 Feb 2023 | 25,000 | 254,414 (0%) | 0% | 17.4 | 434,250 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Jan 2023 | 37,994 | 1,340,320 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 30 Jan 2023 | 37,994 | 340,655 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Jan 2023 | 106,010 | 1,302,326 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jan 2023 | 100,000 | 0 | - | - | Option (right to buy) | |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 17.36 per share. | 24 Jan 2023 | 62,006 | 378,649 (0%) | 0% | 17.4 | 1,076,424 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.20 per share. | 24 Jan 2023 | 100,000 | 440,655 (0%) | 0% | 4.2 | 420,000 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Jan 2023 | 106,010 | 340,655 (0%) | 0% | 0 | Common Stock | |
| Dana T. Aftab | CSO/EVP Disc & Trans Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2023 | 100,000 | 353,001 (0%) | 0% | 0 | Common Stock | |
| George H. Poste | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2022 | 40,000 | 0 | - | - | Option (right to buy) | |
| George H. Poste | Director | Sale of securities on an exchange or to another person at price $ 16.68 per share. | 29 Nov 2022 | 40,000 | 193,189 (0%) | 0% | 16.7 | 667,200 | Common Stock |
| George H. Poste | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 29 Nov 2022 | 40,000 | 233,189 (0%) | 0% | 6.3 | 252,000 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 16.71 per share. | 15 Nov 2022 | 23,304 | 446,665 (0%) | 0% | 16.7 | 389,410 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 16.71 per share. | 15 Nov 2022 | 7,177 | 410,958 (0%) | 0% | 16.7 | 119,928 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 16.71 per share. | 15 Nov 2022 | 8,074 | 509,941 (0%) | 0% | 16.7 | 134,917 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 16.71 per share. | 15 Nov 2022 | 7,177 | 254,414 (0%) | 0% | 16.7 | 119,928 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 17.94 per share. | 12 Sep 2022 | 40,000 | 261,591 (0%) | 0% | 17.9 | 717,600 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2022 | 40,000 | 0 | - | - | Option (right to buy) | |
| Patrick J. Haley | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.21 per share. | 12 Sep 2022 | 40,000 | 301,591 (0%) | 0% | 6.2 | 248,400 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 18.21 per share. | 27 May 2022 | 18,812 | 239,818 (0%) | 0% | 18.2 | 342,567 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.08 per share. | 15 May 2022 | 6,123 | 396,362 (0%) | 0% | 20.1 | 122,950 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.08 per share. | 15 May 2022 | 5,349 | 601,031 (0%) | 0% | 20.1 | 107,408 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.08 per share. | 15 May 2022 | 8,444 | 421,389 (0%) | 0% | 20.1 | 169,556 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.08 per share. | 15 May 2022 | 7,384 | 258,630 (0%) | 0% | 20.1 | 148,271 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.08 per share. | 15 May 2022 | 4,339 | 266,014 (0%) | 0% | 20.1 | 87,127 | Common Stock |
| Jack L. Wyszomierski | Director | Sale of securities on an exchange or to another person at price $ 23.00 per share. | 04 Apr 2022 | 6,696 | 273,192 (0%) | 0% | 23 | 154,008 | Common Stock |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Apr 2022 | 40,000 | 0 | - | - | Option (right to buy) | |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.13 per share. | 04 Apr 2022 | 40,000 | 279,888 (0%) | 0% | 3.1 | 125,200 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 22.43 per share. | 31 Mar 2022 | 10,000 | 269,191 (0%) | 0% | 22.4 | 224,300 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2022 | 10,000 | 40,000 | - | - | Option (right to buy) | |
| Patrick J. Haley | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2022 | 10,000 | 50,000 | - | - | Option (right to buy) | |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 23.00 per share. | 31 Mar 2022 | 10,000 | 269,191 (0%) | 0% | 23 | 230,000 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.21 per share. | 31 Mar 2022 | 10,000 | 279,191 (0%) | 0% | 6.2 | 62,100 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.21 per share. | 31 Mar 2022 | 10,000 | 279,191 (0%) | 0% | 6.2 | 62,100 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 22.00 per share. | 28 Mar 2022 | 13,283 | 605,236 (0%) | 0% | 22 | 292,226 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 22.00 per share. | 28 Mar 2022 | 4,717 | 618,519 (0%) | 0% | 22 | 103,774 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Mar 2022 | 50,000 | 1,196,316 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 270,415 | 399,271 (0%) | 0% | 0 | Common Stock | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 59,490 | 402,485 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 67,875 | 623,236 (0%) | 0% | 0 | Common Stock | |
| Christopher J. Senner | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 75,985 | 429,833 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2022 | 70,715 | 269,191 (0%) | 0% | 0 | Common Stock | |
| Alan M. Garber | Director | Sale of securities on an exchange or to another person at price $ 21.00 per share. | 01 Mar 2022 | 21,301 | 31,417 (0%) | 0% | 21 | 447,321 | Common Stock |
| Alan M. Garber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2022 | 40,000 | 0 | - | - | Option (right to buy) | |
| Alan M. Garber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.13 per share. | 01 Mar 2022 | 40,000 | 52,718 (0%) | 0% | 3.1 | 125,200 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 19.53 per share. | 25 Feb 2022 | 31,238 | 198,476 (0%) | 0% | 19.5 | 610,078 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 24 Feb 2022 | 18,000 | 555,361 (0%) | 0% | 20 | 360,000 | Common Stock |
| Carl B. Feldbaum | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2022 | 20,000 | 0 | - | - | Option (right to buy) | |
| Carl B. Feldbaum | Director | Sale of securities on an exchange or to another person at price $ 19.49 per share. | 22 Feb 2022 | 20,000 | 8,521 (0%) | 0% | 19.5 | 389,800 | Common Stock |
| Carl B. Feldbaum | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.13 per share. | 22 Feb 2022 | 20,000 | 28,521 (0%) | 0% | 3.1 | 62,600 | Common Stock |
| Stelios Papadopoulos | Director | Sale of securities on an exchange or to another person at price $ 19.56 per share. | 22 Feb 2022 | 84,515 | 1,220,036 (0%) | 0% | 19.6 | 1,653,113 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.59 per share. | 15 Feb 2022 | 6,103 | 187,900 (0%) | 0% | 18.6 | 113,455 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.59 per share. | 15 Feb 2022 | 59,044 | 128,856 (0%) | 0% | 18.6 | 1,097,628 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.59 per share. | 15 Feb 2022 | 17,651 | 342,995 (0%) | 0% | 18.6 | 328,132 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.59 per share. | 15 Feb 2022 | 2,526 | 360,646 (0%) | 0% | 18.6 | 46,958 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.59 per share. | 15 Feb 2022 | 11,209 | 573,361 (0%) | 0% | 18.6 | 208,375 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.59 per share. | 15 Feb 2022 | 1,017 | 584,570 (0%) | 0% | 18.6 | 18,906 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.59 per share. | 15 Feb 2022 | 15,626 | 353,848 (0%) | 0% | 18.6 | 290,487 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.59 per share. | 15 Feb 2022 | 2,701 | 369,474 (0%) | 0% | 18.6 | 50,212 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.59 per share. | 15 Feb 2022 | 798 | 244,443 (0%) | 0% | 18.6 | 14,835 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.59 per share. | 15 Feb 2022 | 14,729 | 229,714 (0%) | 0% | 18.6 | 273,812 | Common Stock |
| Vicki L. Goodman | EVP, Prod Dev & Med Aff &CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 19.18 per share. | 04 Jan 2022 | 7,613 | 242,387 (0%) | 0% | 19.2 | 146,017 | Common Stock |
| Vicki L. Goodman | EVP, Prod Dev & Med Aff &CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2022 | 250,000 | 250,000 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2021 | 11,003 | 194,003 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2021 | 11,003 | 1,246,316 (0%) | 0% | 0 | Common Stock | |
| Charles Cohen | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2021 | 1,403 | 248,933 (0%) | 0% | 0 | Common Stock | |
| Charles Cohen | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2021 | 1,403 | 250,336 (0%) | 0% | 0 | Common Stock | |
| Charles Cohen | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2021 | 1,403 | 247,530 (0%) | 0% | 0 | Common Stock | |
| Carl B. Feldbaum | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.13 per share. | 19 Nov 2021 | 20,000 | 28,521 (0%) | 0% | 3.1 | 62,600 | Common Stock |
| Carl B. Feldbaum | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Nov 2021 | 20,000 | 20,000 | - | - | Option (right to buy) | |
| Carl B. Feldbaum | Director | Sale of securities on an exchange or to another person at price $ 17.62 per share. | 19 Nov 2021 | 20,000 | 8,521 (0%) | 0% | 17.6 | 352,400 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 177,132 | 367,288 (0%) | 0% | 18.1 | 3,206,089 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 6,118 | 544,420 (0%) | 0% | 18.1 | 110,736 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 10,530 | 550,538 (0%) | 0% | 18.1 | 190,593 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Sale of securities on an exchange or to another person at price $ 18.09 per share. | 15 Nov 2021 | 47,500 | 411,240 (0%) | 0% | 18.1 | 859,275 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 2,323 | 402,099 (0%) | 0% | 18.1 | 42,046 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 53,022 | 349,077 (0%) | 0% | 18.1 | 959,698 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2021 | 47,500 | 47,500 | - | - | Option (right to buy) | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.21 per share. | 15 Nov 2021 | 47,500 | 458,740 (0%) | 0% | 6.2 | 294,975 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 6,818 | 404,422 (0%) | 0% | 18.1 | 123,406 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 46,743 | 578,214 (0%) | 0% | 18.1 | 846,048 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 6,557 | 626,268 (0%) | 0% | 18.1 | 118,682 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 1,311 | 624,957 (0%) | 0% | 18.1 | 23,729 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 8,227 | 407,301 (0%) | 0% | 18.1 | 148,909 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 46,920 | 357,815 (0%) | 0% | 18.1 | 849,252 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 2,566 | 404,735 (0%) | 0% | 18.1 | 46,445 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 4,323 | 300,205 (0%) | 0% | 18.1 | 78,246 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 983 | 299,222 (0%) | 0% | 18.1 | 17,792 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 18.10 per share. | 15 Nov 2021 | 44,184 | 255,038 (0%) | 0% | 18.1 | 799,730 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 22.03 per share. | 01 Nov 2021 | 5,117 | 632,825 (0%) | 0% | 22.0 | 112,728 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.63 per share. | 30 Sep 2021 | 7,177 | 411,240 (0%) | 0% | 20.6 | 148,062 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 28,950 | 418,417 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 28,950 | 658,418 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.63 per share. | 30 Sep 2021 | 7,593 | 650,825 (0%) | 0% | 20.6 | 156,644 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.63 per share. | 30 Sep 2021 | 8,573 | 415,528 (0%) | 0% | 20.6 | 176,861 | Common Stock |
| Christopher J. Senner | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 32,567 | 424,101 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.63 per share. | 30 Sep 2021 | 5,416 | 304,528 (0%) | 0% | 20.6 | 111,732 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 28,950 | 309,944 (0%) | 0% | 0 | Common Stock | |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.66 per share. | 21 Sep 2021 | 90,000 | 446,591 (0%) | 0% | 3.7 | 329,400 | Common Stock |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Sep 2021 | 90,000 | 0 | - | - | Option (right to buy) | |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.33 per share. | 21 Sep 2021 | 55,057 | 391,534 (0%) | 0% | 20.3 | 1,119,309 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2021 | 55,000 | 0 | - | - | Option (right to buy) | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.90 per share. | 16 Aug 2021 | 55,000 | 444,467 (0%) | 0% | 1.9 | 104,500 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Sale of securities on an exchange or to another person at price $ 18.44 per share. | 16 Aug 2021 | 55,000 | 389,467 (0%) | 0% | 18.4 | 1,014,200 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Jul 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.20 per share. | 26 Jul 2021 | 40,000 | 689,078 (0%) | 0% | 4.2 | 168,000 | Common Stock |
| Charles Cohen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 06 Jul 2021 | 40,000 | 261,375 (0%) | 0% | 6.3 | 252,000 | Common Stock |
| Charles Cohen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.13 per share. | 06 Jul 2021 | 40,000 | 221,375 (0%) | 0% | 3.1 | 125,200 | Common Stock |
| Charles Cohen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| Charles Cohen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Sale of securities on an exchange or to another person at price $ 22.18 per share. | 17 Jun 2021 | 60,000 | 389,467 (0%) | 0% | 22.2 | 1,330,800 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jun 2021 | 60,000 | 115,000 | - | - | Option (right to buy) | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.90 per share. | 17 Jun 2021 | 60,000 | 449,467 (0%) | 0% | 1.9 | 114,000 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 25.39 per share. | 17 May 2021 | 18,000 | 604,822 (0%) | 0% | 25.4 | 457,020 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Payment of exercise price or tax liability using portion of securities received from the company at price $ 16.71 per share. | 17 May 2021 | 7,177 | 579,645 (0%) | 0% | 16.7 | 119,928 | Common Stock |
| Jeffrey J. Hessekiel | EVP, General Counsel & Sec | Sale of securities on an exchange or to another person at price $ 20.07 per share. | 17 May 2021 | 18,000 | 586,822 (0%) | 0% | 20.1 | 361,260 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 24.73 per share. | 15 May 2021 | 14,593 | 280,994 (0%) | 0% | 24.7 | 360,885 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.56 per share. | 15 May 2021 | 3,026 | 295,587 (0%) | 0% | 25.6 | 77,345 | Common Stock |
| George H. Poste | Director | Sale of securities on an exchange or to another person at price $ 24.97 per share. | 14 May 2021 | 40,802 | 157,190 (0%) | 0% | 25.0 | 1,018,826 | Common Stock |
| Vincent T. Marchesi | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 May 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| Vincent T. Marchesi | Director | Sale of securities on an exchange or to another person at price $ 25.04 per share. | 14 May 2021 | 40,000 | 66,115 (0%) | 0% | 25.0 | 1,001,600 | Common Stock |
| Vincent T. Marchesi | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 14 May 2021 | 40,000 | 106,115 (0%) | 0% | 6.3 | 252,000 | Common Stock |
| Stelios Papadopoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| Stelios Papadopoulos | Director | Sale of securities on an exchange or to another person at price $ 25.01 per share. | 11 May 2021 | 5,473 | 1,288,127 (0%) | 0% | 25.0 | 136,880 | Common Stock |
| Stelios Papadopoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.38 per share. | 11 May 2021 | 40,000 | 1,293,600 (0%) | 0% | 3.4 | 135,200 | Common Stock |
| Stelios Papadopoulos | Director | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 11 May 2021 | 5,075 | 1,253,600 (0%) | 0% | 25 | 126,875 | Common Stock |
| Stelios Papadopoulos | Director | Sale of securities on an exchange or to another person at price $ 24.95 per share. | 11 May 2021 | 10,222 | 1,218,675 (0%) | 0% | 25.0 | 255,039 | Common Stock |
| Stelios Papadopoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.13 per share. | 11 May 2021 | 40,000 | 1,258,675 (0%) | 0% | 3.1 | 125,200 | Common Stock |
| Stelios Papadopoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.30 per share. | 11 May 2021 | 40,000 | 1,228,897 (0%) | 0% | 6.3 | 252,000 | Common Stock |
| Stelios Papadopoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| Stelios Papadopoulos | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| Maria C. Freire | Director | Sale of securities on an exchange or to another person at price $ 25.01 per share. | 11 May 2021 | 8,275 | 31,827 (0%) | 0% | 25.0 | 206,958 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2021 | 50,000 | 0 | - | - | Option (right to buy) | |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 26 Apr 2021 | 50,000 | 613,482 (0%) | 0% | 25 | 1,250,000 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.70 per share. | 26 Apr 2021 | 50,000 | 663,482 (0%) | 0% | 1.7 | 85,000 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 25.03 per share. | 26 Apr 2021 | 18,000 | 628,248 (0%) | 0% | 25.0 | 450,540 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 25.03 per share. | 26 Apr 2021 | 7,665 | 297,392 (0%) | 0% | 25.0 | 191,855 | Common Stock |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.38 per share. | 29 Mar 2021 | 40,000 | 237,809 (0%) | 0% | 3.4 | 135,200 | Common Stock |
| Jack L. Wyszomierski | Director | Sale of securities on an exchange or to another person at price $ 22.64 per share. | 29 Mar 2021 | 6,220 | 231,589 (0%) | 0% | 22.6 | 140,821 | Common Stock |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Mar 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| Alan M. Garber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| Alan M. Garber | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.38 per share. | 15 Mar 2021 | 40,000 | 52,718 (0%) | 0% | 3.4 | 135,200 | Common Stock |
| Alan M. Garber | Director | Sale of securities on an exchange or to another person at price $ 23.60 per share. | 15 Mar 2021 | 40,000 | 12,718 (0%) | 0% | 23.6 | 944,000 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 72,885 | 613,482 (0%) | 0% | 0 | Common Stock | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 49,395 | 389,467 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 57,135 | 646,248 (0%) | 0% | 0 | Common Stock | |
| Christopher J. Senner | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 64,150 | 356,591 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 59,570 | 305,057 (0%) | 0% | 0 | Common Stock | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Sale of securities on an exchange or to another person at price $ 22.11 per share. | 01 Mar 2021 | 65,000 | 340,072 (0%) | 0% | 22.1 | 1,437,150 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2021 | 65,000 | 60,000 | - | - | Option (right to buy) | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.70 per share. | 01 Mar 2021 | 65,000 | 405,072 (0%) | 0% | 1.7 | 110,500 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Feb 2021 | 494,700 | 494,700 | - | - | Option (right to buy) | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Feb 2021 | 67,374 | 491,813 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Feb 2021 | 67,374 | 1,059,683 (0%) | 0% | 0 | Common Stock | |
| Charles Cohen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| Charles Cohen | Director | Sale of securities on an exchange or to another person at price $ 22.69 per share. | 24 Feb 2021 | 40,000 | 181,375 (0%) | 0% | 22.7 | 907,600 | Common Stock |
| Charles Cohen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.38 per share. | 24 Feb 2021 | 40,000 | 221,375 (0%) | 0% | 3.4 | 135,200 | Common Stock |
| George H. Poste | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| George H. Poste | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.38 per share. | 22 Feb 2021 | 40,000 | 197,992 (0%) | 0% | 3.4 | 135,200 | Common Stock |
| Vincent T. Marchesi | Director | Sale of securities on an exchange or to another person at price $ 22.29 per share. | 22 Feb 2021 | 24,097 | 66,115 (0%) | 0% | 22.3 | 537,122 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 50,000 | 150,000 | - | - | Option (right to buy) | |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Feb 2021 | 50,000 | 100,000 | - | - | Option (right to buy) | |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.70 per share. | 17 Feb 2021 | 50,000 | 590,597 (0%) | 0% | 1.7 | 85,000 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Sale of securities on an exchange or to another person at price $ 22.50 per share. | 17 Feb 2021 | 50,000 | 540,597 (0%) | 0% | 22.5 | 1,125,000 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.70 per share. | 17 Feb 2021 | 50,000 | 590,597 (0%) | 0% | 1.7 | 85,000 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Sale of securities on an exchange or to another person at price $ 22.35 per share. | 17 Feb 2021 | 50,000 | 540,597 (0%) | 0% | 22.4 | 1,117,500 | Common Stock |
| Carl B. Feldbaum | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2021 | 20,000 | 0 | - | - | Option (right to buy) | |
| Carl B. Feldbaum | Director | Sale of securities on an exchange or to another person at price $ 21.96 per share. | 16 Feb 2021 | 20,000 | 8,521 (0%) | 0% | 22.0 | 439,200 | Common Stock |
| Carl B. Feldbaum | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.38 per share. | 16 Feb 2021 | 20,000 | 28,521 (0%) | 0% | 3.4 | 67,600 | Common Stock |
| Lance Willsey | Director | Sale of securities on an exchange or to another person at price $ 21.92 per share. | 16 Feb 2021 | 39,200 | 425,215 (0%) | 0% | 21.9 | 859,264 | Common Stock |
| Lance Willsey | Director | Sale of securities on an exchange or to another person at price $ 22.34 per share. | 16 Feb 2021 | 800 | 424,415 (0%) | 0% | 22.3 | 17,872 | Common Stock |
| Lance Willsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2021 | 40,000 | 0 | - | - | Option (right to buy) | |
| Lance Willsey | Director | Sale of securities on an exchange or to another person at price $ 21.90 per share. | 16 Feb 2021 | 50,000 | 424,415 (0%) | 0% | 21.9 | 1,095,000 | Common Stock |
| Lance Willsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.38 per share. | 16 Feb 2021 | 40,000 | 464,415 (0%) | 0% | 3.4 | 135,200 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.91 per share. | 15 Feb 2021 | 2,858 | 540,597 (0%) | 0% | 21.9 | 62,619 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.91 per share. | 15 Feb 2021 | 9,789 | 559,187 (0%) | 0% | 21.9 | 214,477 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.91 per share. | 15 Feb 2021 | 3,718 | 340,072 (0%) | 0% | 21.9 | 81,461 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.91 per share. | 15 Feb 2021 | 1,685 | 589,113 (0%) | 0% | 21.9 | 36,918 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.91 per share. | 15 Feb 2021 | 4,105 | 292,441 (0%) | 0% | 21.9 | 89,941 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.91 per share. | 12 Feb 2021 | 1,400 | 245,487 (0%) | 0% | 21.9 | 30,674 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Sale of securities on an exchange or to another person at price $ 21.57 per share. | 12 Feb 2021 | 45,000 | 246,887 (0%) | 0% | 21.6 | 970,650 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 9,745 | 487,144 (0%) | 0% | 0 | Common Stock | |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.56 per share. | 03 Feb 2021 | 14,982 | 543,455 (0%) | 0% | 22.6 | 337,994 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 71,293 | 558,437 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 23,238 | 409,879 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Feb 2021 | 126,565 | 992,309 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Feb 2021 | 187,239 | 1,118,874 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 03 Feb 2021 | 187,239 | 386,641 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 224,287 | 634,166 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.56 per share. | 03 Feb 2021 | 65,190 | 568,976 (0%) | 0% | 22.6 | 1,470,686 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 9,370 | 292,494 (0%) | 0% | 0 | Common Stock | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.56 per share. | 03 Feb 2021 | 19,997 | 343,790 (0%) | 0% | 22.6 | 451,132 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 71,293 | 363,787 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 4,998 | 546,752 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 59,411 | 606,163 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.56 per share. | 03 Feb 2021 | 15,365 | 590,798 (0%) | 0% | 22.6 | 346,634 | Common Stock |
| Christopher J. Senner | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 9,745 | 255,341 (0%) | 0% | 0 | Common Stock | |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.56 per share. | 03 Feb 2021 | 18,206 | 296,546 (0%) | 0% | 22.6 | 410,727 | Common Stock |
| Christopher J. Senner | EVP and CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 59,411 | 314,752 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 59,411 | 303,154 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2021 | 4,498 | 243,743 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 22.56 per share. | 03 Feb 2021 | 11,267 | 291,887 (0%) | 0% | 22.6 | 254,184 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.70 per share. | 01 Feb 2021 | 65,000 | 348,124 (0%) | 0% | 1.7 | 110,500 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2021 | 65,000 | 125,000 | - | - | Option (right to buy) | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Sale of securities on an exchange or to another person at price $ 22.08 per share. | 01 Feb 2021 | 65,000 | 283,124 (0%) | 0% | 22.1 | 1,435,200 | Common Stock |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.66 per share. | 12 Jan 2021 | 30,000 | 275,596 (0%) | 0% | 3.7 | 109,800 | Common Stock |
| Christopher J. Senner | EVP and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jan 2021 | 30,000 | 90,000 | - | - | Option (right to buy) | |
| Christopher J. Senner | EVP and CFO | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 12 Jan 2021 | 30,000 | 245,596 (0%) | 0% | 25 | 750,000 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.70 per share. | 04 Jan 2021 | 65,000 | 348,124 (0%) | 0% | 1.7 | 110,500 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2021 | 65,000 | 190,000 | - | - | Option (right to buy) | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Sale of securities on an exchange or to another person at price $ 20.32 per share. | 04 Jan 2021 | 65,000 | 283,124 (0%) | 0% | 20.3 | 1,320,800 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.27 per share. | 04 Jan 2021 | 30,000 | 521,754 (0%) | 0% | 7.3 | 218,100 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.90 per share. | 04 Jan 2021 | 20,000 | 541,754 (0%) | 0% | 1.9 | 38,000 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Jan 2021 | 2,500 | 491,754 (0%) | 0% | 0 | Common Stock | |
| Jeffrey J. Hessekiel | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2021 | 20,000 | 0 | - | - | Option (right to buy) | |
| Jeffrey J. Hessekiel | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Jan 2021 | 30,000 | 0 | - | - | Option (right to buy) | |
| Charles Cohen | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 01 Jan 2021 | 1,513 | 251,739 (0%) | 0% | 0 | Common Stock | |
| Charles Cohen | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 01 Jan 2021 | 1,513 | 253,252 (0%) | 0% | 0 | Common Stock | |
| Charles Cohen | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 01 Jan 2021 | 1,513 | 254,765 (0%) | 0% | 0 | Common Stock | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2020 | 65,000 | 255,000 | - | - | Option (right to buy) | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.70 per share. | 18 Dec 2020 | 65,000 | 348,124 (0%) | 0% | 1.7 | 110,500 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Sale of securities on an exchange or to another person at price $ 20.01 per share. | 18 Dec 2020 | 65,000 | 283,124 (0%) | 0% | 20.0 | 1,300,650 | Common Stock |
| Lance Willsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.82 per share. | 04 Dec 2020 | 106,142 | 474,415 (0%) | 0% | 5.8 | 617,746 | Common Stock |
| Lance Willsey | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Dec 2020 | 106,142 | 0 | - | - | Option (right to buy) | |
| Vincent T. Marchesi | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.82 per share. | 24 Nov 2020 | 40,004 | 130,216 (0%) | 0% | 5.8 | 232,823 | Common Stock |
| Vincent T. Marchesi | Director | Sale of securities on an exchange or to another person at price $ 18.50 per share. | 24 Nov 2020 | 40,004 | 90,212 (0%) | 0% | 18.5 | 740,074 | Common Stock |
| Vincent T. Marchesi | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Nov 2020 | 40,004 | 0 | - | - | Option (right to buy) | |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 2,583 | 477,399 (0%) | 0% | 20.2 | 52,073 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 2,685 | 489,667 (0%) | 0% | 20.2 | 54,130 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 9,685 | 479,982 (0%) | 0% | 20.2 | 195,250 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 10,530 | 581,778 (0%) | 0% | 20.2 | 212,285 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 6,526 | 592,308 (0%) | 0% | 20.2 | 131,564 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 7,898 | 573,880 (0%) | 0% | 20.2 | 159,224 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 2,014 | 283,124 (0%) | 0% | 20.2 | 40,602 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 2,479 | 291,956 (0%) | 0% | 20.2 | 49,977 | Common Stock |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 6,818 | 285,138 (0%) | 0% | 20.2 | 137,451 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 6,557 | 466,385 (0%) | 0% | 20.2 | 132,189 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2020 | 30,000 | 30,000 | - | - | Option (right to buy) | |
| Jeffrey J. Hessekiel | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.27 per share. | 15 Nov 2020 | 30,000 | 494,254 (0%) | 0% | 7.3 | 218,100 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 2,131 | 464,254 (0%) | 0% | 20.2 | 42,961 | Common Stock |
| Jeffrey J. Hessekiel | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 1,573 | 472,942 (0%) | 0% | 20.2 | 31,712 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 2,737 | 256,456 (0%) | 0% | 20.2 | 55,178 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 2,633 | 245,596 (0%) | 0% | 20.2 | 53,081 | Common Stock |
| Christopher J. Senner | EVP and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 8,227 | 248,229 (0%) | 0% | 20.2 | 165,856 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 1,339 | 248,352 (0%) | 0% | 20.2 | 26,994 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 6,198 | 242,154 (0%) | 0% | 20.2 | 124,952 | Common Stock |
| Patrick J. Haley | EVP, Commercial | Payment of exercise price or tax liability using portion of securities received from the company at price $ 20.16 per share. | 15 Nov 2020 | 2,909 | 239,245 (0%) | 0% | 20.2 | 58,645 | Common Stock |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Nov 2020 | 62,403 | 0 | - | - | Option (right to buy) | |
| Jack L. Wyszomierski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.82 per share. | 10 Nov 2020 | 62,403 | 231,809 (0%) | 0% | 5.8 | 363,185 | Common Stock |
| Jack L. Wyszomierski | Director | Sale of securities on an exchange or to another person at price $ 20.61 per share. | 10 Nov 2020 | 34,000 | 197,809 (0%) | 0% | 20.6 | 700,740 | Common Stock |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Oct 2020 | 213,879 | 547,070 (0%) | 0% | 0 | Common Stock | |
| Gisela M. Schwab | Pres, Prod Dev & Med Aff & CMO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.79 per share. | 22 Oct 2020 | 55,235 | 491,835 (0%) | 0% | 21.8 | 1,203,571 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 22 Oct 2020 | 25,000 | 964,135 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.79 per share. | 22 Oct 2020 | 177,132 | 598,834 (0%) | 0% | 21.8 | 3,859,706 | Common Stock |
| Michael M. Morrissey | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Oct 2020 | 672,861 | 775,966 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 22 Oct 2020 | 32,500 | 931,635 (0%) | 0% | 0 | Common Stock | |
| Michael M. Morrissey | Director, President and CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 22 Oct 2020 | 42,500 | 989,135 (0%) | 0% | 0 | Common Stock | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Oct 2020 | 213,879 | 347,457 (0%) | 0% | 0 | Common Stock | |
| Peter Lamb | EVP, Scientific Strategy & CSO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 21.79 per share. | 22 Oct 2020 | 53,022 | 294,435 (0%) | 0% | 21.8 | 1,155,349 | Common Stock |