1.5M XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 82,500 | 82,500 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 110,000 | 110,000 | - | - | Stock Option (Right to Buy) | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 36,666 | 36,666 | - | - | Stock Option (Right to Buy) | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 27,500 | 27,500 | - | - | Restricted Stock Units | |
| Raju Prasad | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 36,666 | 36,666 | - | - | Stock Option (Right to Buy) | |
| Raju Prasad | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2025 | 10,000 | 20,000 | - | - | Restricted Stock Units | |
| Raju Prasad | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 41.80 per share. | 14 Mar 2025 | 3,762 | 12,714 (0%) | 0% | 41.8 | 157,252 | Common Shares |
| Raju Prasad | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2025 | 10,000 | 16,476 (0%) | 0% | - | Common Shares | |
| Raju Prasad | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 27,500 | 27,500 | - | - | Restricted Stock Units | |
| Julianne Bruno | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 27,500 | 27,500 | - | - | Restricted Stock Units | |
| Julianne Bruno | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 36,666 | 36,666 | - | - | Stock Option (Right to Buy) | |
| Naimish Patel | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 32,500 | 32,500 | - | - | Restricted Stock Units | |
| Naimish Patel | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2025 | 46,667 | 46,667 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 19,250 | 190,863 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 9,000 | 0 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 19,250 | 38,500 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 43.32 per share. | 10 Mar 2025 | 4,462 | 185,428 (0%) | 0% | 43.3 | 193,294 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 9,000 | 189,890 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 42.42 per share. | 10 Mar 2025 | 9,973 | 180,890 (0%) | 0% | 42.4 | 423,055 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 2,250 | 0 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 5,500 | 11,000 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 43.32 per share. | 10 Mar 2025 | 1,116 | 78,664 (0%) | 0% | 43.3 | 48,345 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 2,250 | 79,780 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 42.42 per share. | 10 Mar 2025 | 2,850 | 77,530 (0%) | 0% | 42.4 | 120,897 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 5,500 | 80,380 (0%) | 0% | - | Common Shares | |
| Julianne Bruno | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 42.42 per share. | 10 Mar 2025 | 1,198 | 8,263 (0%) | 0% | 42.4 | 50,819 | Common Shares |
| Julianne Bruno | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 2,399 | 9,461 (0%) | 0% | - | Common Shares | |
| Julianne Bruno | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 435 | 8,698 (0%) | 0% | - | Common Shares | |
| Julianne Bruno | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 43.32 per share. | 10 Mar 2025 | 190 | 8,508 (0%) | 0% | 43.3 | 8,231 | Common Shares |
| Julianne Bruno | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 2,399 | 4,796 | - | - | Restricted Stock Units | |
| Julianne Bruno | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2025 | 435 | 0 | - | - | Restricted Stock Units | |
| John T. Greene | Director | Purchase of securities on an exchange or from another person at price $ 44.85 per share. | 26 Feb 2025 | 7,000 | 7,000 (0%) | 0% | 44.8 | 313,948 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 55.21 per share. | 19 Feb 2025 | 18,360 | 171,613 (0%) | 0% | 55.2 | 1,013,564 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 52.80 per share. | 18 Feb 2025 | 6,928 | 189,973 (0%) | 0% | 52.8 | 365,798 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 55.05 per share. | 18 Feb 2025 | 11,640 | 196,901 (0%) | 0% | 55.1 | 640,782 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 13,250 | 208,541 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 13,250 | 13,250 | - | - | Restricted Stock Units | |
| Julianne Bruno | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 650 | 7,395 (0%) | 0% | - | Common Shares | |
| Julianne Bruno | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 52.80 per share. | 18 Feb 2025 | 333 | 7,062 (0%) | 0% | 52.8 | 17,582 | Common Shares |
| Julianne Bruno | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 650 | 650 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2025 | 3,825 | 3,825 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2025 | 20,000 | 0 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 52.80 per share. | 16 Feb 2025 | 1,947 | 74,880 (0%) | 0% | 52.8 | 102,802 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2025 | 3,825 | 76,827 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 53.85 per share. | 16 Feb 2025 | 9,595 | 73,002 (0%) | 0% | 53.9 | 516,691 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Feb 2025 | 20,000 | 82,597 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.21 per share. | 24 Dec 2024 | 13,751 | 195,291 (0%) | 0% | 16.2 | 222,904 | Common Shares |
| Kulkarni Samarth | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Dec 2024 | 13,751 | 0 | - | - | Stock Option (Right to Buy) | |
| Kulkarni Samarth | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 55.10 per share. | 02 Dec 2024 | 15,000 | 181,540 (0%) | 0% | 55.1 | 826,565 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 55.43 per share. | 11 Nov 2024 | 23,121 | 203,419 (0%) | 0% | 55.4 | 1,281,597 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 56.27 per share. | 11 Nov 2024 | 6,879 | 196,540 (0%) | 0% | 56.3 | 387,081 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2024 | 55,000 | 55,000 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2024 | 400,000 | 400,000 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2024 | 18,333 | 18,333 | - | - | Stock Option (Right to Buy) | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2024 | 30,000 | 30,000 | - | - | Restricted Stock Units | |
| Raju Prasad | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2024 | 18,333 | 18,333 | - | - | Stock Option (Right to Buy) | |
| Raju Prasad | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2024 | 15,000 | 15,000 | - | - | Restricted Stock Units | |
| Julianne Bruno | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2024 | 18,333 | 18,333 | - | - | Stock Option (Right to Buy) | |
| Naimish Patel | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2024 | 18,333 | 18,333 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 46.28 per share. | 13 Oct 2024 | 4,293 | 226,540 (0%) | 0% | 46.3 | 198,680 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2024 | 8,333 | 16,667 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2024 | 8,333 | 230,833 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2024 | 2,113 | 4,227 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 46.28 per share. | 13 Oct 2024 | 1,089 | 62,597 (0%) | 0% | 46.3 | 50,399 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Oct 2024 | 2,113 | 63,686 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Aug 2024 | 100,000 | 222,500 (0%) | 0% | 0 | Common Shares | |
| Julianne Bruno | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jun 2024 | 7,000 | 10,111 (0%) | 0% | - | Common Shares | |
| Julianne Bruno | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jun 2024 | 7,000 | 0 | - | - | Restricted Stock Units | |
| Julianne Bruno | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 56.09 per share. | 20 Jun 2024 | 3,366 | 6,745 (0%) | 0% | 56.1 | 188,799 | Common Shares |
| Maria Fardis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 13,000 | 13,000 | - | - | Stock Option (Right to Buy) | |
| Sandesh Mahatme | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 13,000 | 13,000 | - | - | Stock Option (Right to Buy) | |
| John T. Greene | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 13,000 | 13,000 | - | - | Stock Option (Right to Buy) | |
| Katherine A. High | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 13,000 | 13,000 | - | - | Stock Option (Right to Buy) | |
| Douglas A. Treco | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 13,000 | 13,000 | - | - | Stock Option (Right to Buy) | |
| H. Edward Fleming | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 13,000 | 13,000 | - | - | Stock Option (Right to Buy) | |
| Simeon J. George | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 13,000 | 13,000 | - | - | Stock Option (Right to buy) | |
| Ali Behbahani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 13,000 | 13,000 | - | - | Stock Option (Right to buy) | |
| Christian Rommel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 26,000 | 26,000 | - | - | Stock Option (Right to Buy) | |
| Naimish Patel | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2024 | 85,000 | 85,000 | - | - | Stock Option (Right to Buy) | |
| Naimish Patel | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2024 | 40,000 | 40,000 | - | - | Restricted Stock Units | |
| Julianne Bruno | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2024 | 20,000 | 20,000 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.40 per share. | 15 Apr 2024 | 1,204 | 208,122 (0%) | 0% | 60.4 | 72,722 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2024 | 19,582 | 0 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 59.88 per share. | 15 Apr 2024 | 18,378 | 209,326 (0%) | 0% | 59.9 | 1,100,510 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 15 Apr 2024 | 19,582 | 227,704 (0%) | 0% | 19.1 | 374,408 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Mar 2024 | 78,750 | 78,750 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Mar 2024 | 105,000 | 105,000 | - | - | Stock Option (Right to Buy) | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Mar 2024 | 33,333 | 33,333 | - | - | Stock Option (Right to Buy) | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Mar 2024 | 25,000 | 25,000 | - | - | Restricted Stock Units | |
| Raju Prasad | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Mar 2024 | 25,000 | 25,000 | - | - | Restricted Stock Units | |
| Raju Prasad | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Mar 2024 | 36,168 | 36,168 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 15 Mar 2024 | 20,000 | 228,122 (0%) | 0% | 19.1 | 382,400 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2024 | 20,000 | 19,582 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 73.06 per share. | 15 Mar 2024 | 9,387 | 208,122 (0%) | 0% | 73.1 | 685,818 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 71.97 per share. | 15 Mar 2024 | 10,613 | 217,509 (0%) | 0% | 72.0 | 763,810 | Common Shares |
| Raju Prasad | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 72.69 per share. | 14 Mar 2024 | 3,524 | 6,476 (0%) | 0% | 72.7 | 256,160 | Common Shares |
| Raju Prasad | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2024 | 10,000 | 30,000 | - | - | Restricted Stock Units | |
| Raju Prasad | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2024 | 10,000 | 10,000 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2024 | 19,250 | 213,507 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2024 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2024 | 19,250 | 57,750 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 74.44 per share. | 10 Mar 2024 | 4,583 | 208,122 (0%) | 0% | 74.4 | 341,159 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2024 | 9,000 | 212,705 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 78.26 per share. | 10 Mar 2024 | 9,802 | 203,705 (0%) | 0% | 78.3 | 767,105 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2024 | 2,250 | 2,250 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2024 | 5,500 | 16,500 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 74.44 per share. | 10 Mar 2024 | 1,146 | 61,174 (0%) | 0% | 74.4 | 85,308 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2024 | 2,250 | 62,320 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 78.26 per share. | 10 Mar 2024 | 2,801 | 60,070 (0%) | 0% | 78.3 | 219,206 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2024 | 5,500 | 62,871 (0%) | 0% | - | Common Shares | |
| George J. Simeon | Director | Grant, award, or other acquisition of securities at price $ 71.50 per share. | 27 Feb 2024 | 769,196 | 769,196 (1%) | 1% | 71.5 | 54,997,514 | Common Shares |
| George Simeon J. | Director | Grant, award, or other acquisition of securities at price $ 71.50 per share. | 27 Feb 2024 | 216,578 | 216,578 (0%) | 0% | 71.5 | 15,485,327 | Common Shares |
| Simeon J. George | Director | Grant, award, or other acquisition of securities at price $ 71.50 per share. | 27 Feb 2024 | 63,177 | 63,177 (0%) | 0% | 71.5 | 4,517,156 | Common Shares |
| Kulkarni Samarth | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 79.67 per share. | 18 Feb 2024 | 6,370 | 194,257 (0%) | 0% | 79.7 | 507,498 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2024 | 13,250 | 200,627 (0%) | 0% | - | Common Shares | |
| Kasinger James R. | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2024 | 3,825 | 59,284 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2024 | 3,825 | 7,650 | - | - | Restricted Stock Units | |
| R. James Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 79.67 per share. | 18 Feb 2024 | 1,913 | 57,371 (0%) | 0% | 79.7 | 152,409 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2024 | 13,250 | 26,500 | - | - | Restricted Stock Units | |
| Kulkarni Samarth | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 81.66 per share. | 15 Feb 2024 | 1,100 | 187,377 (0%) | 0% | 81.7 | 89,831 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 81.04 per share. | 15 Feb 2024 | 5,951 | 188,477 (0%) | 0% | 81.0 | 482,257 | Common Shares |
| Kulkarni Samarth | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 15 Feb 2024 | 20,000 | 207,377 (0%) | 0% | 19.1 | 382,400 | Common Shares |
| Kulkarni Samarth | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Feb 2024 | 20,000 | 39,582 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 79.94 per share. | 15 Feb 2024 | 12,949 | 194,428 (0%) | 0% | 79.9 | 1,035,090 | Common Shares |
| Kulkarni Samarth | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 61.10 per share. | 29 Jan 2024 | 700 | 187,377 (0%) | 0% | 61.1 | 42,770 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 29 Jan 2024 | 50,000 | 237,377 (0%) | 0% | 19.1 | 956,000 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Jan 2024 | 50,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Kulkarni Samarth | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 60.50 per share. | 29 Jan 2024 | 49,300 | 188,077 (0%) | 0% | 60.5 | 2,982,803 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 16 Jan 2024 | 20,000 | 207,377 (0%) | 0% | 19.1 | 382,400 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 62.50 per share. | 16 Jan 2024 | 20,000 | 187,377 (0%) | 0% | 62.5 | 1,250,058 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jan 2024 | 20,000 | 59,582 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 65.63 per share. | 30 May 2023 | 9,300 | 389,777 (0%) | 0% | 65.6 | 610,359 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 66.83 per share. | 30 May 2023 | 2,400 | 387,377 (0%) | 0% | 66.8 | 160,401 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 May 2023 | 25,000 | 79,582 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 30 May 2023 | 25,000 | 412,377 (0%) | 0% | 19.1 | 478,000 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 63.61 per share. | 30 May 2023 | 7,301 | 405,076 (0%) | 0% | 63.6 | 464,452 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 64.46 per share. | 30 May 2023 | 5,999 | 399,077 (0%) | 0% | 64.5 | 386,682 | Common Shares |
| Phuong Khanh Morrow | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.91 per share. | 23 May 2023 | 2,527 | 4,411 (0%) | 0% | 65.9 | 166,555 | Common Shares |
| Phuong Khanh Morrow | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2023 | 6,938 | 20,812 | - | - | Restricted Stock Units | |
| Phuong Khanh Morrow | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 May 2023 | 6,938 | 6,938 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 25 Apr 2023 | 25,000 | 412,377 (0%) | 0% | 19.1 | 478,000 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Apr 2023 | 25,000 | 104,582 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 51.45 per share. | 25 Apr 2023 | 4,393 | 387,377 (0%) | 0% | 51.5 | 226,021 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.50 per share. | 25 Apr 2023 | 20,607 | 391,770 (0%) | 0% | 50.5 | 1,040,616 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.78 per share. | 29 Mar 2023 | 5,281 | 387,377 (0%) | 0% | 44.8 | 236,506 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 44.37 per share. | 29 Mar 2023 | 19,719 | 392,658 (0%) | 0% | 44.4 | 874,997 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 29 Mar 2023 | 25,000 | 412,377 (0%) | 0% | 19.1 | 478,000 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Mar 2023 | 25,000 | 129,582 | - | - | Stock Option (Right to Buy) | |
| Raju Prasad | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2023 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Raju Prasad | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Mar 2023 | 40,000 | 40,000 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 43.22 per share. | 10 Mar 2023 | 5,358 | 382,463 (0%) | 0% | 43.2 | 231,573 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 9,000 | 18,000 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 11,833 | 387,821 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2023 | 77,000 | 77,000 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2023 | 188,000 | 188,000 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 11,833 | 0 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 43.22 per share. | 10 Mar 2023 | 4,086 | 387,377 (0%) | 0% | 43.2 | 176,597 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 9,000 | 391,463 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 2,250 | 4,500 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 2,833 | 54,899 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 43.22 per share. | 10 Mar 2023 | 1,283 | 53,616 (0%) | 0% | 43.2 | 55,451 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 2,250 | 55,866 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 43.22 per share. | 10 Mar 2023 | 1,022 | 54,844 (0%) | 0% | 43.2 | 44,171 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2023 | 2,833 | 0 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2023 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2023 | 22,000 | 22,000 | - | - | Restricted Stock Units | |
| Phuong Khanh Morrow | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2023 | 22,000 | 22,000 | - | - | Restricted Stock Units | |
| Phuong Khanh Morrow | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2023 | 44,620 | 44,620 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 49.20 per share. | 27 Feb 2023 | 1,100 | 375,988 (0%) | 0% | 49.2 | 54,118 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 48.57 per share. | 27 Feb 2023 | 13,720 | 377,088 (0%) | 0% | 48.6 | 666,415 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 47.71 per share. | 27 Feb 2023 | 10,180 | 390,808 (0%) | 0% | 47.7 | 485,710 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2023 | 25,000 | 154,582 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 27 Feb 2023 | 25,000 | 400,988 (0%) | 0% | 19.1 | 478,000 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2023 | 13,250 | 382,361 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2023 | 13,250 | 39,750 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 48.26 per share. | 18 Feb 2023 | 6,373 | 375,988 (0%) | 0% | 48.3 | 307,561 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2023 | 3,825 | 54,016 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2023 | 3,825 | 11,475 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 48.26 per share. | 18 Feb 2023 | 1,950 | 52,066 (0%) | 0% | 48.3 | 94,107 | Common Shares |
| Brendan Smith | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2023 | 3,825 | 11,475 | - | - | Restricted Stock Units | |
| Brendan Smith | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 48.26 per share. | 18 Feb 2023 | 1,392 | 5,072 (0%) | 0% | 48.3 | 67,178 | Common Shares |
| Brendan Smith | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2023 | 3,825 | 6,464 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 50.60 per share. | 27 Jan 2023 | 1,800 | 392,311 (0%) | 0% | 50.6 | 91,086 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2023 | 25,000 | 179,582 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 51.54 per share. | 27 Jan 2023 | 23,200 | 369,111 (0%) | 0% | 51.5 | 1,195,712 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 27 Jan 2023 | 25,000 | 394,111 (0%) | 0% | 19.1 | 478,000 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.81 per share. | 06 Dec 2022 | 58,233 | 369,111 (0%) | 0% | 1.8 | 105,402 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Dec 2022 | 58,233 | 0 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2022 | 40,000 | 330,279 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2022 | 40,000 | 0 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.26 per share. | 03 Dec 2022 | 19,401 | 310,878 (0%) | 0% | 52.3 | 1,013,896 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2022 | 6,667 | 0 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.26 per share. | 03 Dec 2022 | 3,234 | 50,191 (0%) | 0% | 52.3 | 169,009 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2022 | 6,667 | 53,425 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 53.58 per share. | 28 Nov 2022 | 17,118 | 298,161 (0%) | 0% | 53.6 | 917,246 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Nov 2022 | 25,000 | 229,582 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 55.40 per share. | 28 Nov 2022 | 2,310 | 290,279 (0%) | 0% | 55.4 | 127,983 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 54.85 per share. | 28 Nov 2022 | 5,572 | 292,589 (0%) | 0% | 54.8 | 305,598 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 28 Nov 2022 | 25,000 | 315,279 (0%) | 0% | 19.1 | 478,000 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Oct 2022 | 19,582 | 13,751 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Oct 2022 | 5,418 | 254,582 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 55.69 per share. | 26 Oct 2022 | 7,188 | 290,279 (0%) | 0% | 55.7 | 400,333 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 54.97 per share. | 26 Oct 2022 | 11,312 | 297,467 (0%) | 0% | 55.0 | 621,774 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 54.06 per share. | 26 Oct 2022 | 4,000 | 308,779 (0%) | 0% | 54.1 | 216,254 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 52.73 per share. | 26 Oct 2022 | 2,500 | 312,779 (0%) | 0% | 52.7 | 131,830 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.12 per share. | 26 Oct 2022 | 5,418 | 315,279 (0%) | 0% | 19.1 | 103,592 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.21 per share. | 26 Oct 2022 | 19,582 | 309,861 (0%) | 0% | 16.2 | 317,424 | Common Shares |
| Brendan Smith | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2022 | 3,750 | 11,250 | - | - | Restricted Stock Units | |
| Brendan Smith | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 55.76 per share. | 14 Oct 2022 | 1,111 | 2,639 (0%) | 0% | 55.8 | 61,949 | Common Shares |
| Brendan Smith | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2022 | 3,750 | 3,750 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Oct 2022 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Brendan Smith | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Oct 2022 | 14,000 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Phuong Khanh Morrow | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Oct 2022 | 9,380 | 9,380 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 64.58 per share. | 28 Sep 2022 | 23,200 | 292,079 (0%) | 0% | 64.6 | 1,498,214 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2022 | 25,000 | 33,333 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 64.97 per share. | 28 Sep 2022 | 1,800 | 290,279 (0%) | 0% | 65.0 | 116,946 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.21 per share. | 28 Sep 2022 | 25,000 | 315,279 (0%) | 0% | 16.2 | 405,250 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.21 per share. | 29 Aug 2022 | 25,000 | 315,279 (0%) | 0% | 16.2 | 405,250 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Aug 2022 | 25,000 | 58,333 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 67.64 per share. | 29 Aug 2022 | 163 | 290,279 (0%) | 0% | 67.6 | 11,025 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 66.98 per share. | 29 Aug 2022 | 20,764 | 290,442 (0%) | 0% | 67.0 | 1,390,669 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 66.14 per share. | 29 Aug 2022 | 4,073 | 311,206 (0%) | 0% | 66.1 | 269,390 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2022 | 150,000 | 150,000 | - | - | Performance-based Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2022 | 25,000 | 25,000 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2022 | 20,000 | 20,000 | - | - | Restricted Stock Units | |
| Lawrence Otto Klein | CBO & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2022 | 12,500 | 12,500 | - | - | Restricted Stock Units | |
| Brendan Smith | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2022 | 10,000 | 10,000 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 75.73 per share. | 27 Jul 2022 | 12,759 | 294,187 (0%) | 0% | 75.7 | 966,265 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.57 per share. | 27 Jul 2022 | 8,333 | 298,612 (0%) | 0% | 12.6 | 104,746 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.21 per share. | 27 Jul 2022 | 16,667 | 315,279 (0%) | 0% | 16.2 | 270,172 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 75.64 per share. | 27 Jul 2022 | 6,933 | 308,346 (0%) | 0% | 75.6 | 524,402 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 76.37 per share. | 27 Jul 2022 | 700 | 307,646 (0%) | 0% | 76.4 | 53,461 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 77.79 per share. | 27 Jul 2022 | 700 | 306,946 (0%) | 0% | 77.8 | 54,455 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 76.29 per share. | 27 Jul 2022 | 3,308 | 290,879 (0%) | 0% | 76.3 | 252,382 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 77.97 per share. | 27 Jul 2022 | 600 | 290,279 (0%) | 0% | 78.0 | 46,783 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jul 2022 | 8,333 | 0 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jul 2022 | 16,667 | 83,333 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Jun 2022 | 25,000 | 8,333 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 62.32 per share. | 29 Jun 2022 | 4,740 | 290,279 (0%) | 0% | 62.3 | 295,407 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 61.42 per share. | 29 Jun 2022 | 20,260 | 295,019 (0%) | 0% | 61.4 | 1,244,454 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.57 per share. | 29 Jun 2022 | 25,000 | 315,279 (0%) | 0% | 12.6 | 314,250 | Common Shares |
| Maria Fardis | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 24,000 | 24,000 | - | - | Stock Option (Right to Buy) | |
| Simeon J. George | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Bradley J. Bolzon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| John T. Greene | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Ali Behbahani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Katherine A. High | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Douglas A. Treco | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| H Edward Fleming | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Jun 2022 | 12,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Phuong Khanh Morrow | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2022 | 90,000 | 90,000 | - | - | Stock Option (Right to Buy) | |
| Phuong Khanh Morrow | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 May 2022 | 27,750 | 27,750 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 62.56 per share. | 10 Mar 2022 | 5,487 | 285,432 (0%) | 0% | 62.6 | 343,267 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 9,000 | 27,000 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 11,834 | 11,833 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 61.08 per share. | 10 Mar 2022 | 4,153 | 290,279 (0%) | 0% | 61.1 | 253,665 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 9,000 | 294,432 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 11,834 | 290,919 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 62.56 per share. | 10 Mar 2022 | 1,321 | 45,218 (0%) | 0% | 62.6 | 82,642 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 2,250 | 6,750 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 2,834 | 2,833 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 61.08 per share. | 10 Mar 2022 | 1,039 | 46,429 (0%) | 0% | 61.1 | 63,462 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 2,250 | 47,468 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 2,834 | 46,539 (0%) | 0% | - | Common Shares | |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 4,584 | 26,909 (0%) | 0% | - | Common Shares | |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 3,000 | 9,000 | - | - | Restricted Stock Units | |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 4,584 | 4,583 | - | - | Restricted Stock Units | |
| Lawrence Otto Klein | CBO & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 61.08 per share. | 10 Mar 2022 | 1,229 | 26,797 (0%) | 0% | 61.1 | 75,067 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2022 | 3,000 | 28,026 (0%) | 0% | - | Common Shares | |
| Lawrence Otto Klein | CBO & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 62.56 per share. | 10 Mar 2022 | 1,883 | 25,026 (0%) | 0% | 62.6 | 117,800 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2022 | 53,000 | 53,000 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2022 | 115,000 | 115,000 | - | - | Stock Option (Right to Buy) | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2022 | 34,200 | 34,200 | - | - | Stock Option (Right to Buy) | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2022 | 15,300 | 15,300 | - | - | Restricted Stock Units | |
| Lawrence Otto Klein | CBO & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2022 | 20,400 | 20,400 | - | - | Restricted Stock Units | |
| Lawrence Otto Klein | CBO & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2022 | 46,200 | 46,200 | - | - | Stock Option (Right to Buy) | |
| Brendan Smith | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2022 | 15,300 | 15,300 | - | - | Restricted Stock Units | |
| Brendan Smith | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2022 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2021 | 17,750 | 58,233 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.81 per share. | 20 Dec 2021 | 17,750 | 279,085 (0%) | 0% | 1.8 | 32,128 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2021 | 80,000 | 40,000 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2021 | 80,000 | 299,153 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.17 per share. | 03 Dec 2021 | 37,818 | 261,335 (0%) | 0% | 69.2 | 2,615,871 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2021 | 13,333 | 49,845 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.17 per share. | 03 Dec 2021 | 6,303 | 43,542 (0%) | 0% | 69.2 | 435,979 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2021 | 13,333 | 6,667 | - | - | Restricted Stock Units | |
| Tony W. Ho | Executive VP, Head of R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2021 | 26,667 | 13,333 | - | - | Restricted Stock Units | |
| Tony W. Ho | Executive VP, Head of R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2021 | 26,667 | 64,971 (0%) | 0% | - | Common Shares | |
| Tony W. Ho | Executive VP, Head of R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.17 per share. | 03 Dec 2021 | 12,607 | 52,364 (0%) | 0% | 69.2 | 872,026 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2021 | 26,667 | 33,510 (0%) | 0% | - | Common Shares | |
| Lawrence Otto Klein | CBO & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.17 per share. | 03 Dec 2021 | 11,185 | 22,325 (0%) | 0% | 69.2 | 773,666 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Dec 2021 | 26,667 | 13,333 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2021 | 43,000 | 43,000 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.81 per share. | 15 Oct 2021 | 33,000 | 219,932 (0%) | 0% | 1.8 | 59,730 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2021 | 33,000 | 75,983 | - | - | Stock Option (Right to Buy) | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2021 | 10,800 | 10,800 | - | - | Stock Option (Right to Buy) | |
| Tony W. Ho | Executive VP, Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2021 | 13,800 | 13,800 | - | - | Stock Option (Right to Buy) | |
| Lawrence Otto Klein | CBO & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2021 | 13,800 | 13,800 | - | - | Stock Option (Right to Buy) | |
| Brendan Smith | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Oct 2021 | 90,000 | 90,000 | - | - | Stock Option (Right to Buy) | |
| Brendan Smith | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Oct 2021 | 15,000 | 15,000 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2021 | 10,000 | 33,911 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Sale or transfer of securities back to the company at price $ 0.00 per share. | 10 Sep 2021 | 10,000 | 0 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.86 per share. | 10 Sep 2021 | 4,741 | 29,170 (0%) | 0% | 117.9 | 558,774 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.86 per share. | 10 Sep 2021 | 4,207 | 6,843 (0%) | 0% | 117.9 | 495,837 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 10 Sep 2021 | 10,000 | 0 | - | - | Restricted Stock Units | |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2021 | 10,000 | 11,050 (0%) | 0% | - | Common Shares | |
| Michael J. Tomsicek | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 139.46 per share. | 06 Aug 2021 | 5,989 | 1,891 (0%) | 0% | 139.5 | 835,226 | Common Shares |
| Michael J. Tomsicek | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2021 | 25,000 | 131,000 | - | - | Stock Option (Right to Buy) | |
| Michael J. Tomsicek | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 138.22 per share. | 06 Aug 2021 | 19,011 | 7,880 (0%) | 0% | 138.2 | 2,627,700 | Common Shares |
| Michael J. Tomsicek | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.75 per share. | 06 Aug 2021 | 25,000 | 26,891 (0%) | 0% | 17.8 | 443,750 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 126.41 per share. | 19 Jul 2021 | 4,472 | 150,855 (0%) | 0% | 126.4 | 565,289 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 128.71 per share. | 19 Jul 2021 | 700 | 148,831 (0%) | 0% | 128.7 | 90,094 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 127.36 per share. | 19 Jul 2021 | 1,324 | 149,531 (0%) | 0% | 127.4 | 168,619 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 125.67 per share. | 19 Jul 2021 | 3,504 | 155,327 (0%) | 0% | 125.7 | 440,345 | Common Shares |
| Rodger Novak | Director, President | Sale of securities on an exchange or to another person at price $ 165.00 per share. | 30 Jun 2021 | 25,000 | 573,007 (0%) | 0% | 165 | 4,125,000 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 152.38 per share. | 28 Jun 2021 | 1,540 | 162,569 (0%) | 0% | 152.4 | 234,660 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 152.42 per share. | 28 Jun 2021 | 1,200 | 0 (0%) | 0% | 152.4 | 182,906 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 151.24 per share. | 28 Jun 2021 | 6,646 | 1,200 (0%) | 0% | 151.2 | 1,005,162 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 150.49 per share. | 28 Jun 2021 | 12,753 | 7,846 (0%) | 0% | 150.5 | 1,919,237 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 149.47 per share. | 28 Jun 2021 | 7,981 | 20,599 (0%) | 0% | 149.5 | 1,192,915 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 148.58 per share. | 28 Jun 2021 | 12,176 | 28,580 (0%) | 0% | 148.6 | 1,809,095 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 147.43 per share. | 28 Jun 2021 | 4,780 | 40,756 (0%) | 0% | 147.4 | 704,725 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 146.69 per share. | 28 Jun 2021 | 600 | 45,536 (0%) | 0% | 146.7 | 88,016 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 145.92 per share. | 28 Jun 2021 | 1,400 | 46,136 (0%) | 0% | 145.9 | 204,284 | Common Shares |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 847 | 47,536 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 6,018 | 0 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 6,018 | 6,018 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 27,861 | 16,434 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 18,973 | 46,689 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 84,085 | 0 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 2,633 | 84,085 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 12,189 | 6,268 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 2,378 | 81,452 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 11,011 | 5,614 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 79,074 | 79,074 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 366,084 | 215,915 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 3,650 | 622 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 27,716 | 27,716 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 158,522 | 0 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 158,522 | 158,522 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 28 Jun 2021 | 615,607 | 104,874 (0%) | 1% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 156.54 per share. | 28 Jun 2021 | 269 | 158,831 (0%) | 0% | 156.5 | 42,110 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 156.54 per share. | 28 Jun 2021 | 549 | 0 (0%) | 0% | 156.5 | 85,941 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 155.27 per share. | 28 Jun 2021 | 132 | 159,100 (0%) | 0% | 155.3 | 20,496 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 155.27 per share. | 28 Jun 2021 | 268 | 549 (0%) | 0% | 155.3 | 41,613 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 154.57 per share. | 28 Jun 2021 | 1,119 | 159,232 (0%) | 0% | 154.6 | 172,959 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 154.57 per share. | 28 Jun 2021 | 2,281 | 817 (0%) | 0% | 154.6 | 352,564 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 153.54 per share. | 28 Jun 2021 | 2,218 | 160,351 (0%) | 0% | 153.5 | 340,549 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 153.54 per share. | 28 Jun 2021 | 4,519 | 3,098 (0%) | 0% | 153.5 | 693,842 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 152.38 per share. | 28 Jun 2021 | 3,139 | 7,617 (0%) | 0% | 152.4 | 478,309 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 151.49 per share. | 28 Jun 2021 | 3,144 | 164,109 (0%) | 0% | 151.5 | 476,300 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 151.49 per share. | 28 Jun 2021 | 6,403 | 10,756 (0%) | 0% | 151.5 | 970,022 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 150.65 per share. | 28 Jun 2021 | 1,578 | 167,253 (0%) | 0% | 150.7 | 237,726 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 150.65 per share. | 28 Jun 2021 | 3,216 | 17,159 (0%) | 0% | 150.7 | 484,491 | Common Shares |
| Rodger Novak | Director, President | Sale of securities on an exchange or to another person at price $ 156.55 per share. | 28 Jun 2021 | 25,000 | 598,007 (0%) | 0% | 156.6 | 3,913,750 | Common Shares |
| Rodger Novak | Director, President | Sale of securities on an exchange or to another person at price $ 130.28 per share. | 21 Jun 2021 | 50 | 623,007 (1%) | 0% | 130.3 | 6,514 | Common Shares |
| Rodger Novak | Director, President | Sale of securities on an exchange or to another person at price $ 125.58 per share. | 21 Jun 2021 | 1,171 | 646,836 (1%) | 0% | 125.6 | 147,054 | Common Shares |
| Rodger Novak | Director, President | Sale of securities on an exchange or to another person at price $ 128.76 per share. | 21 Jun 2021 | 12,630 | 630,356 (1%) | 0% | 128.8 | 1,626,239 | Common Shares |
| Rodger Novak | Director, President | Sale of securities on an exchange or to another person at price $ 127.71 per share. | 21 Jun 2021 | 2,969 | 642,986 (1%) | 0% | 127.7 | 379,171 | Common Shares |
| Rodger Novak | Director, President | Sale of securities on an exchange or to another person at price $ 126.62 per share. | 21 Jun 2021 | 881 | 645,955 (1%) | 0% | 126.6 | 111,552 | Common Shares |
| Rodger Novak | Director, President | Sale of securities on an exchange or to another person at price $ 129.46 per share. | 21 Jun 2021 | 7,299 | 623,057 (1%) | 0% | 129.5 | 944,929 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 126.86 per share. | 15 Jun 2021 | 16,129 | 191,207 (0%) | 0% | 126.9 | 2,046,125 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jun 2021 | 30,000 | 63,333 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 127.51 per share. | 15 Jun 2021 | 3,488 | 187,719 (0%) | 0% | 127.5 | 444,755 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.57 per share. | 15 Jun 2021 | 30,000 | 217,719 (0%) | 0% | 12.6 | 377,100 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 125.39 per share. | 15 Jun 2021 | 10,383 | 207,336 (0%) | 0% | 125.4 | 1,301,924 | Common Shares |
| Simeon J. George | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Bradley J. Bolzon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| John T. Greene | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Ali Behbahani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Katherine A. High | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Douglas A. Treco | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| H Edward Fleming | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2021 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 115.80 per share. | 01 Jun 2021 | 779 | 187,719 (0%) | 0% | 115.8 | 90,208 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Mar 2021 | 20,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 44.67 per share. | 23 Mar 2021 | 12,000 | 25,050 (0%) | 0% | 44.7 | 536,040 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 51.49 per share. | 23 Mar 2021 | 22,000 | 47,050 (0%) | 0% | 51.5 | 1,132,780 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 29.87 per share. | 23 Mar 2021 | 10,000 | 57,050 (0%) | 0% | 29.9 | 298,700 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.87 per share. | 23 Mar 2021 | 20,000 | 77,050 (0%) | 0% | 40.9 | 817,400 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.43 per share. | 23 Mar 2021 | 12,000 | 89,050 (0%) | 0% | 14.4 | 173,160 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.66 per share. | 23 Mar 2021 | 12,000 | 101,050 (0%) | 0% | 17.7 | 211,920 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Sale of securities on an exchange or to another person at price $ 128.20 per share. | 23 Mar 2021 | 88,000 | 13,050 (0%) | 0% | 128.2 | 11,281,600 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Sale of securities on an exchange or to another person at price $ 126.97 per share. | 23 Mar 2021 | 12,000 | 1,050 (0%) | 0% | 127.0 | 1,523,640 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Mar 2021 | 12,000 | 2,666 | - | - | Stock Option (Right to Buy) | |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Mar 2021 | 12,000 | 3,000 | - | - | Stock Option (Right to Buy) | |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Mar 2021 | 22,000 | 38,000 | - | - | Stock Option (Right to Buy) | |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Mar 2021 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Mar 2021 | 12,000 | 43,000 | - | - | Stock Option (Right to Buy) | |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 129.36 per share. | 22 Mar 2021 | 3,600 | 57,149 (0%) | 0% | 129.4 | 465,678 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 134.93 per share. | 22 Mar 2021 | 300 | 30,375 (0%) | 0% | 134.9 | 40,478 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 134.33 per share. | 22 Mar 2021 | 5,237 | 30,675 (0%) | 0% | 134.3 | 703,495 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 133.28 per share. | 22 Mar 2021 | 9,334 | 35,912 (0%) | 0% | 133.3 | 1,244,070 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 132.53 per share. | 22 Mar 2021 | 6,090 | 45,246 (0%) | 0% | 132.5 | 807,092 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 131.14 per share. | 22 Mar 2021 | 2,400 | 51,336 (0%) | 0% | 131.1 | 314,741 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 130.42 per share. | 22 Mar 2021 | 3,413 | 53,736 (0%) | 0% | 130.4 | 445,112 | Common Shares |
| Michael J. Tomsicek | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 124.15 per share. | 10 Mar 2021 | 1,352 | 1,891 (0%) | 0% | 124.2 | 167,851 | Common Shares |
| Michael J. Tomsicek | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2021 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| Michael J. Tomsicek | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2021 | 25,360 | 25,360 | - | - | Stock Option (Right to Buy) | |
| Michael J. Tomsicek | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2021 | 2,833 | 3,243 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2021 | 11,833 | 194,024 (0%) | 0% | - | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2021 | 36,000 | 36,000 | - | - | Restricted Stock Units | |
| Samarth Kulkarni | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2021 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 124.15 per share. | 10 Mar 2021 | 5,526 | 188,498 (0%) | 0% | 124.2 | 686,053 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2021 | 2,833 | 25,264 (0%) | 0% | - | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2021 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| James R. Kasinger | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2021 | 25,360 | 25,360 | - | - | Stock Option (Right to Buy) | |
| James R. Kasinger | General Counsel and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 124.15 per share. | 10 Mar 2021 | 1,353 | 23,911 (0%) | 0% | 124.2 | 167,975 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2021 | 4,583 | 40,445 (0%) | 0% | - | Common Shares | |
| Tony W. Ho | Executive VP, Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2021 | 9,000 | 9,000 | - | - | Restricted Stock Units | |
| Tony W. Ho | Executive VP, Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2021 | 23,334 | 23,334 | - | - | Stock Option (Right to Buy) | |
| Tony W. Ho | Executive VP, Head of R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 124.15 per share. | 10 Mar 2021 | 2,141 | 38,304 (0%) | 0% | 124.1 | 265,805 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2021 | 12,000 | 12,000 | - | - | Restricted Stock Units | |
| Lawrence Otto Klein | CBO & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Mar 2021 | 33,334 | 33,334 | - | - | Stock Option (Right to Buy) | |
| Lawrence Otto Klein | CBO & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 124.15 per share. | 10 Mar 2021 | 2,141 | 13,050 (0%) | 0% | 124.1 | 265,805 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2021 | 4,583 | 15,191 (0%) | 0% | - | Common Shares | |
| Tony W. Ho | Executive VP, Head of R&D | Payment of exercise price or tax liability using portion of securities received from the company at price $ 114.65 per share. | 05 Mar 2021 | 1,585 | 35,862 (0%) | 0% | 114.6 | 181,720 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2021 | 3,333 | 37,447 (0%) | 0% | - | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 7,341 | 16,625 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 244,056 | 581,999 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 52,716 | 52,716 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 565 | 60,749 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 4,012 | 0 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 4,012 | 4,012 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 18,574 | 44,295 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 12,648 | 60,184 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 56,056 | 0 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 1,755 | 56,056 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 8,126 | 18,457 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 01 Mar 2021 | 1,585 | 54,301 (0%) | 0% | 0 | Common Shares | |
| Samarth Kulkarni | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 130.25 per share. | 01 Mar 2021 | 798 | 182,191 (0%) | 0% | 130.3 | 103,940 | Common Shares |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 6,018 | 6,018 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 18,973 | 46,689 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 84,085 | 0 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 2,633 | 84,085 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 12,189 | 26,583 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 2,378 | 81,452 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 11,011 | 23,966 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 79,074 | 79,074 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 366,084 | 826,055 (1%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 3,650 | 4,272 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 27,716 | 27,716 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 158,522 | 0 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 158,522 | 158,522 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 615,607 | 720,481 (1%) | 1% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 151.82 per share. | 19 Feb 2021 | 3,463 | 168,831 (0%) | 0% | 151.8 | 525,752 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 150.99 per share. | 19 Feb 2021 | 27,932 | 172,294 (0%) | 0% | 151.0 | 4,217,461 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 150.10 per share. | 19 Feb 2021 | 38,132 | 200,226 (0%) | 0% | 150.1 | 5,723,773 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 149.24 per share. | 19 Feb 2021 | 23,276 | 238,358 (0%) | 0% | 149.2 | 3,473,785 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 147.79 per share. | 19 Feb 2021 | 78,200 | 261,634 (0%) | 0% | 147.8 | 11,557,069 | Common Shares |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 847 | 47,536 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 6,018 | 0 (0%) | 0% | 0 | Common Shares | |
| Bradley J. Bolzon | Director | Other type of transaction at price $ 0.00 per share. | 19 Feb 2021 | 27,861 | 62,869 (0%) | 0% | 0 | Common Shares | |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 203.58 per share. | 19 Jan 2021 | 6,785 | 43,146 (0%) | 0% | 203.6 | 1,381,290 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Jan 2021 | 27,500 | 12,500 | - | - | Stock Option (right to buy) | |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 207.61 per share. | 19 Jan 2021 | 2,100 | 22,431 (0%) | 0% | 207.6 | 435,981 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 206.05 per share. | 19 Jan 2021 | 1,800 | 24,531 (0%) | 0% | 206.1 | 370,890 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 51.49 per share. | 19 Jan 2021 | 27,500 | 49,931 (0%) | 0% | 51.5 | 1,415,975 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 205.60 per share. | 19 Jan 2021 | 8,997 | 26,331 (0%) | 0% | 205.6 | 1,849,783 | Common Shares |
| James R. Kasinger | General Counsel and Secretary | Sale of securities on an exchange or to another person at price $ 204.40 per share. | 19 Jan 2021 | 7,818 | 35,328 (0%) | 0% | 204.4 | 1,597,999 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2021 | 20,000 | 108,983 | - | - | Stock Option (Right to Buy) | |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 212.75 per share. | 15 Jan 2021 | 6,525 | 193,324 (0%) | 0% | 212.8 | 1,388,194 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 211.83 per share. | 15 Jan 2021 | 3,140 | 199,849 (0%) | 0% | 211.8 | 665,146 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.81 per share. | 15 Jan 2021 | 20,000 | 202,989 (0%) | 0% | 1.8 | 36,200 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 217.44 per share. | 15 Jan 2021 | 1,304 | 182,989 (0%) | 0% | 217.4 | 283,542 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 216.50 per share. | 15 Jan 2021 | 1,708 | 184,293 (0%) | 0% | 216.5 | 369,782 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 214.68 per share. | 15 Jan 2021 | 1,700 | 186,001 (0%) | 0% | 214.7 | 364,956 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 213.71 per share. | 15 Jan 2021 | 5,623 | 187,701 (0%) | 0% | 213.7 | 1,201,691 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.43 per share. | 15 Jan 2021 | 16,334 | 26,942 (0%) | 0% | 14.4 | 235,700 | Common Shares |
| Lawrence Otto Klein | CBO & COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 153.11 per share. | 02 Jan 2021 | 9,392 | 10,608 (0%) | 0% | 153.1 | 1,438,009 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.81 per share. | 29 Dec 2020 | 13,800 | 182,989 (0%) | 0% | 1.8 | 24,978 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Dec 2020 | 13,800 | 128,983 | - | - | Stock Option (right to buy) | |
| Tony W. Ho | Executive VP, Head of R&D | Sale of securities on an exchange or to another person at price $ 150.61 per share. | 21 Dec 2020 | 2,951 | 33,964 (0%) | 0% | 150.6 | 444,450 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Sale of securities on an exchange or to another person at price $ 149.73 per share. | 21 Dec 2020 | 5,000 | 36,915 (0%) | 0% | 149.7 | 748,650 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Sale of securities on an exchange or to another person at price $ 148.38 per share. | 21 Dec 2020 | 8,400 | 41,915 (0%) | 0% | 148.4 | 1,246,392 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Sale of securities on an exchange or to another person at price $ 147.05 per share. | 21 Dec 2020 | 1,400 | 50,315 (0%) | 0% | 147.1 | 205,870 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Sale of securities on an exchange or to another person at price $ 152.41 per share. | 21 Dec 2020 | 500 | 51,715 (0%) | 0% | 152.4 | 76,205 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Sale of securities on an exchange or to another person at price $ 151.58 per share. | 21 Dec 2020 | 1,100 | 52,215 (0%) | 0% | 151.6 | 166,738 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Sale of securities on an exchange or to another person at price $ 150.16 per share. | 21 Dec 2020 | 1,600 | 53,315 (0%) | 0% | 150.2 | 240,256 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Sale of securities on an exchange or to another person at price $ 149.18 per share. | 21 Dec 2020 | 900 | 54,915 (0%) | 0% | 149.2 | 134,262 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.90 per share. | 21 Dec 2020 | 23,551 | 57,515 (0%) | 0% | 16.9 | 398,012 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Sale of securities on an exchange or to another person at price $ 148.11 per share. | 21 Dec 2020 | 1,700 | 55,815 (0%) | 0% | 148.1 | 251,787 | Common Shares |
| Tony W. Ho | Executive VP, Head of R&D | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Dec 2020 | 23,551 | 236,449 | - | - | Stock Option (right to buy) | |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 151.05 per share. | 16 Dec 2020 | 931 | 339,834 (0%) | 0% | 151.0 | 140,625 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 151.05 per share. | 16 Dec 2020 | 969 | 0 (0%) | 0% | 151.0 | 146,365 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 150.14 per share. | 16 Dec 2020 | 958 | 340,765 (0%) | 0% | 150.1 | 143,837 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 150.14 per share. | 16 Dec 2020 | 995 | 969 (0%) | 0% | 150.1 | 149,392 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 149.12 per share. | 16 Dec 2020 | 2,009 | 341,723 (0%) | 0% | 149.1 | 299,586 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 149.12 per share. | 16 Dec 2020 | 2,091 | 1,964 (0%) | 0% | 149.1 | 311,815 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 148.28 per share. | 16 Dec 2020 | 2,576 | 343,732 (0%) | 0% | 148.3 | 381,972 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 148.28 per share. | 16 Dec 2020 | 2,679 | 4,055 (0%) | 0% | 148.3 | 397,245 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 147.00 per share. | 16 Dec 2020 | 878 | 346,308 (0%) | 0% | 147.0 | 129,068 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 147.00 per share. | 16 Dec 2020 | 914 | 6,734 (0%) | 0% | 147.0 | 134,360 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 141.53 per share. | 10 Dec 2020 | 6,648 | 31,729 (0%) | 0% | 141.5 | 940,923 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 144.85 per share. | 10 Dec 2020 | 15,900 | 7,648 (0%) | 0% | 144.9 | 2,303,155 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 143.26 per share. | 10 Dec 2020 | 2,223 | 23,548 (0%) | 0% | 143.3 | 318,462 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 142.42 per share. | 10 Dec 2020 | 5,958 | 25,771 (0%) | 0% | 142.4 | 848,562 | Common Shares |
| Bradley J. Bolzon | Director | Sale of securities on an exchange or to another person at price $ 140.62 per share. | 10 Dec 2020 | 2,271 | 38,377 (0%) | 0% | 140.6 | 319,345 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.81 per share. | 10 Dec 2020 | 20,000 | 189,189 (0%) | 0% | 1.8 | 36,200 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 141.98 per share. | 10 Dec 2020 | 5,034 | 178,655 (0%) | 0% | 142.0 | 714,727 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 141.17 per share. | 10 Dec 2020 | 5,500 | 183,689 (0%) | 0% | 141.2 | 776,435 | Common Shares |
| Samarth Kulkarni | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2020 | 20,000 | 142,783 | - | - | Stock Option (Right to Buy) |