Insider Trading disclosures for Biocryst Pharmaceuticals Inc.

The latest disclosure was made by Vincent J. Milano in Biocryst Pharmaceuticals Inc. where a trade of 653 Common Stock done at an average price of $8.6 was reported to US exchanges on Feb. 28, 2025.

Insider trading is the trading of a company’s securities by individuals with access to confidential or material non-public information about the company. A company is required to report trading by corporate officers, directors, or other company members with significant access to privileged information to the Securities and Exchange Commission (SEC).

Client Name	Client Category	Action	Reported to Exchange	Quantity	Post Transaction Holding	Traded %	Avg. Price	Value	Security Type
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 8.61 per share.	28 Feb 2025	653	76,737 (0%)	0%	8.6	5,622	Common Stock
K. Gayer Charles	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2024	260,950	260,950	-		-	Emp. Stock Option (Right to Buy)
Barnes Alane	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2024	250,100	250,100	-		-	Emp. Stock Option (Right to Buy)
Anthony Doyle	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2024	120,700	380,328 (0%)	0%		0	Common Stock
Anthony Doyle	Chief Financial Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.39 per share.	19 Dec 2024	2,461	377,867 (0%)	0%	7.4	18,187	Common Stock
Doyle Anthony	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2024	250,100	250,100	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Chief Legal Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.39 per share.	19 Dec 2024	2,461	412,729 (0%)	0%	7.4	18,187	Common Stock
Thackray Helen M.	Chief R&D Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2024	125,950	390,939 (0%)	0%		0	Common Stock
Gayer K. Charles	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2024	125,950	426,007 (0%)	0%		0	Common Stock
Stonehouse Jon P.	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	19 Dec 2024	10,000	30,000 (0%)	0%		0	Common Stock
Thackray M. Helen	Chief R&D Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.39 per share.	19 Dec 2024	6,096	384,843 (0%)	0%	7.4	45,049	Common Stock
Jon P. Stonehouse	Director, President & CEO	Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.39 per share.	19 Dec 2024	14,010	1,449,109 (0%)	0%	7.4	103,534	Common Stock
M. Helen Thackray	Chief R&D Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2024	260,950	260,950	-		-	Emp. Stock Option (Right to Buy)
Jon Stonehouse P.	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	19 Dec 2024	10,000	30,000 (0%)	0%		0	Common Stock
P. Stonehouse Jon	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2024	750,250	750,250	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2024	120,700	415,190 (0%)	0%		0	Common Stock
Charles Gayer K.	Chief Commercial Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.39 per share.	19 Dec 2024	2,461	423,546 (0%)	0%	7.4	18,187	Common Stock
Jon Stonehouse P.	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	19 Dec 2024	20,000	1,429,109 (0%)	0%		0	Common Stock
Stonehouse Jon P.	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2024	362,100	1,463,119 (0%)	0%		0	Common Stock
Jon P. Stonehouse	Director, President & CEO	Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.53 per share.	14 Dec 2024	27,525	1,101,019 (0%)	0%	7.5	207,263	Common Stock
Alane Barnes	Chief Legal Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.53 per share.	14 Dec 2024	8,613	294,490 (0%)	0%	7.5	64,856	Common Stock
Helen M. Thackray	Chief R&D Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.53 per share.	14 Dec 2024	7,150	264,989 (0%)	0%	7.5	53,840	Common Stock
Charles K. Gayer	Chief Commercial Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.53 per share.	14 Dec 2024	8,251	300,057 (0%)	0%	7.5	62,130	Common Stock
Anthony Doyle	Chief Financial Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 7.53 per share.	14 Dec 2024	7,890	259,628 (0%)	0%	7.5	59,412	Common Stock
Nancy J. Hutson	Director	Sale of securities on an exchange or to another person at price $ 7.54 per share.	13 Dec 2024	7,000	86,638 (0%)	0%	7.5	52,780	Common Stock
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 7.50 per share.	29 Nov 2024	750	76,084 (0%)	0%	7.5	5,625	Common Stock
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 8.69 per share.	30 Aug 2024	647	75,334 (0%)	0%	8.7	5,622	Common Stock
Amy McKee	Director	Sale of securities on an exchange or to another person at price $ 6.32 per share.	24 Jun 2024	8,600	27,831 (0%)	0%	6.3	54,352	Common Stock
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	49,933	49,933	-		-	Automatic Stock Option Grant
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	6,820	70,159 (0%)	0%		0	Common Stock
George B. Abercrombie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	6,820	36,431 (0%)	0%		0	Common Stock
George B. Abercrombie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	49,933	49,933	-		-	Automatic Stock Option Grant
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	49,933	49,933	-		-	Automatic Stock Option Grant
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	6,820	51,771 (0%)	0%		0	Common Stock
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	49,933	49,933	-		-	Automatic Stock Option Grant
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	6,820	93,638 (0%)	0%		0	Common Stock
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	6,820	74,687 (0%)	0%		0	Common Stock
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	49,933	49,933	-		-	Automatic Stock Option Grant
Steven Galson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	6,820	36,431 (0%)	0%		0	Common Stock
Steven Galson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	49,933	49,933	-		-	Automatic Stock Option Grant
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	6,820	59,550 (0%)	0%		0	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	49,933	49,933	-		-	Automatic Stock Option Grant
Theresa M. Heggie	Director	Sale of securities on an exchange or to another person at price $ 6.11 per share.	12 Jun 2024	6,698	52,852 (0%)	0%	6.1	40,925	Common Stock
Amy McKee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	49,933	49,933	-		-	Automatic Stock Option Grant
Amy McKee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 Jun 2024	6,820	36,431 (0%)	0%		0	Common Stock
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 6.46 per share.	31 May 2024	870	67,867 (0%)	0%	6.5	5,620	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 6.46 per share.	31 May 2024	870	52,730 (0%)	0%	6.5	5,620	Common Stock
Alan G. Levin	Director	Purchase of securities on an exchange or from another person at price $ 6.36 per share.	30 May 2024	7,861	44,951 (0%)	0%	6.4	49,996	Common Stock
Stephen J. Aselage	Director	Purchase of securities on an exchange or from another person at price $ 6.40 per share.	24 May 2024	2,500	2,500 (0%)	0%	6.4	16,000	Common Stock
Nancy J. Hutson	Director	Purchase of securities on an exchange or from another person at price $ 6.38 per share.	20 May 2024	5,000	86,818 (0%)	0%	6.4	31,900	Common Stock
Vincent J. Milano	Director	Purchase of securities on an exchange or from another person at price $ 6.25 per share.	20 May 2024	15,000	66,997 (0%)	0%	6.3	93,750	Common Stock
Helen M. Thackray	Chief R&D Officer	Purchase of securities on an exchange or from another person at price $ 5.86 per share.	14 May 2024	30,000	272,139 (0%)	0%	5.9	175,800	Common Stock
Anthony Doyle	Chief Financial Officer	Purchase of securities on an exchange or from another person at price $ 5.57 per share.	14 May 2024	36,300	266,744 (0%)	0%	5.6	202,191	Common Stock
Jon P. Stonehouse	Director, President & CEO	Purchase of securities on an exchange or from another person at price $ 5.55 per share.	13 May 2024	30,000	1,127,770 (0%)	0%	5.6	166,500	Common Stock
Steven Galson	Director	Purchase of securities on an exchange or from another person at price $ 5.49 per share.	13 May 2024	21,940	51,551 (0%)	0%	5.5	120,451	Common Stock
Alane Barnes	Chief Legal Officer	Purchase of securities on an exchange or from another person at price $ 5.53 per share.	13 May 2024	5,000	300,762 (0%)	0%	5.5	27,650	Common Stock
Charles K. Gayer	Chief Commercial Officer	Purchase of securities on an exchange or from another person at price $ 5.47 per share.	13 May 2024	30,000	307,533 (0%)	0%	5.5	164,100	Common Stock
Helen M. Thackray	Chief R&D Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.08 per share.	31 Mar 2024	7,525	242,139 (0%)	0%	5.1	38,227	Common Stock
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 5.63 per share.	29 Feb 2024	999	51,997 (0%)	0%	5.6	5,624	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 5.63 per share.	29 Feb 2024	999	51,860 (0%)	0%	5.6	5,624	Common Stock
P. Jon Stonehouse	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	03 Jan 2024	10,000	20,000 (0%)	0%		0	Common Stock
Stonehouse P. Jon	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	03 Jan 2024	20,000	1,094,770 (0%)	0%		0	Common Stock
Jon Stonehouse P.	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	03 Jan 2024	10,000	20,000 (0%)	0%		0	Common Stock
Alane Barnes	Chief Legal Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.05 per share.	19 Dec 2023	2,482	293,539 (0%)	0%	6.0	15,016	Common Stock
Helen M. Thackray	Chief R&D Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.05 per share.	19 Dec 2023	5,580	249,664 (0%)	0%	6.1	33,759	Common Stock
Gayer Charles K.	Chief Commercial Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.05 per share.	19 Dec 2023	2,482	274,533 (0%)	0%	6.0	15,016	Common Stock
Stonehouse P. Jon	Director, President & CEO	Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.05 per share.	19 Dec 2023	14,089	1,114,770 (0%)	0%	6.0	85,238	Common Stock
Doyle Anthony	Chief Financial Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.05 per share.	19 Dec 2023	2,482	227,444 (0%)	0%	6.0	15,016	Common Stock
Stonehouse Jon P.	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2023	127,500	1,142,451 (0%)	0%		0	Common Stock
M. Thackray Helen	Chief R&D Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.43 per share.	14 Dec 2023	3,031	255,244 (0%)	0%	6.4	19,489	Common Stock
Helen Thackray M.	Chief R&D Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2023	51,000	258,275 (0%)	0%		0	Common Stock
Doyle Anthony	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2023	34,000	235,401 (0%)	0%		0	Common Stock
M. Thackray Helen	Chief R&D Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2023	238,000	238,000	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2023	64,000	300,036 (0%)	0%		0	Common Stock
Alane Barnes	Chief Legal Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.43 per share.	14 Dec 2023	4,015	296,021 (0%)	0%	6.4	25,816	Common Stock
Barnes Alane	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2023	158,500	158,500	-		-	Emp. Stock Option (Right to Buy)
K. Gayer Charles	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2023	158,500	158,500	-		-	Emp. Stock Option (Right to Buy)
Anthony Doyle	Chief Financial Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.43 per share.	14 Dec 2023	5,475	229,926 (0%)	0%	6.4	35,204	Common Stock
Gayer K. Charles	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2023	34,000	282,855 (0%)	0%		0	Common Stock
Gayer K. Charles	Chief Commercial Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.43 per share.	14 Dec 2023	5,840	277,015 (0%)	0%	6.4	37,551	Common Stock
Stonehouse P. Jon	Director, President & CEO	Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.43 per share.	14 Dec 2023	13,592	1,128,859 (0%)	0%	6.4	87,397	Common Stock
Anthony Doyle	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2023	158,500	158,500	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2023	595,000	595,000	-		-	Emp. Stock Option (Right to Buy)
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	16,745	94,684 (0%)	0%		0	Common Stock
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	39,072	39,072	-		-	Automatic Stock Option Grant
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	39,072	39,072	-		-	Automatic Stock Option Grant
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	16,745	49,251 (0%)	0%		0	Common Stock
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	39,072	39,072	-		-	Automatic Stock Option Grant
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	16,745	63,339 (0%)	0%		0	Common Stock
George B. Abercrombie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	39,072	39,072	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	16,745	29,611 (0%)	0%		0	Common Stock
Steven Galson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	16,745	29,611 (0%)	0%		0	Common Stock
Steven Galson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	39,072	39,072	-		-	Automatic Stock Option Grant
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	39,072	39,072	-		-	Automatic Stock Option Grant
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	16,745	49,114 (0%)	0%		0	Common Stock
Amy McKee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	16,745	29,611 (0%)	0%		0	Common Stock
Amy McKee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	39,072	39,072	-		-	Automatic Stock Option Grant
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	39,072	39,072	-		-	Automatic Stock Option Grant
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	16,745	37,090 (0%)	0%		0	Common Stock
Kenneth B. Lee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	39,072	39,072	-		-	Automatic Stock Option Grant
Kenneth B. Lee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Jun 2023	16,745	68,863 (0%)	0%		0	Common Stock
Jon P. Stonehouse	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	13 Jun 2023	25,000	1,014,794 (0%)	0%		0	Common Stock
Nancy J. Hutson	Director	Sale of securities on an exchange or to another person at price $ 8.04 per share.	13 Jun 2023	12,866	81,818 (0%)	0%	8.0	103,443	Common Stock
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 8.27 per share.	31 May 2023	1,360	20,345 (0%)	0%	8.3	11,247	Common Stock
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 8.27 per share.	31 May 2023	680	32,506 (0%)	0%	8.3	5,624	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 8.27 per share.	31 May 2023	680	32,369 (0%)	0%	8.3	5,624	Common Stock
Helen M. Thackray	Chief R&D Officer	Sale of securities on an exchange or to another person at price $ 8.29 per share.	03 Apr 2023	7,000	207,275 (0%)	0%	8.3	58,030	Common Stock
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	21 Mar 2023	31,055	305,995	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	21 Mar 2023	31,055	1,039,794 (0%)	0%	3.2	99,997	Common Stock
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 8.85 per share.	28 Feb 2023	1,271	18,985 (0%)	0%	8.8	11,248	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 8.85 per share.	28 Feb 2023	2,259	100,198 (0%)	0%	8.8	19,992	Common Stock
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 8.85 per share.	28 Feb 2023	635	31,826 (0%)	0%	8.9	5,620	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 8.85 per share.	28 Feb 2023	635	31,689 (0%)	0%	8.9	5,620	Common Stock
Jon P. Stonehouse	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	01 Feb 2023	5,000	10,000 (0%)	0%		0	Common Stock
Jon P. Stonehouse	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	01 Feb 2023	5,000	10,000 (0%)	0%		0	Common Stock
Jon P. Stonehouse	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	01 Feb 2023	10,000	1,008,739 (0%)	0%		0	Common Stock
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Feb 2023	100,000	0	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Sale of securities on an exchange or to another person at price $ 10.38 per share.	01 Feb 2023	100,000	1,008,739 (0%)	0%	10.4	1,038,000	Common Stock
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.45 per share.	01 Feb 2023	100,000	1,108,739 (0%)	0%	5.5	545,000	Common Stock
Kenneth B. Lee	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 Jan 2023	15,000	0	-		-	Automatic Stock Option Grant
Kenneth B. Lee	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.71 per share.	31 Jan 2023	15,000	52,118 (0%)	0%	1.7	25,650	Common Stock
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	127,500	1,015,230 (0%)	0%		0	Common Stock
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	595,000	595,000	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	158,500	158,500	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	34,000	232,770 (0%)	0%		0	Common Stock
Helen M. Thackray	Chief R&D Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	81,000	214,275 (0%)	0%		0	Common Stock
Helen M. Thackray	Chief R&D Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	238,000	238,000	-		-	Emp. Stock Option (Right to Buy)
Michael L. Jones	Exec. Director, Finance - PAO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	5,900	16,653 (0%)	0%		0	Common Stock
Michael L. Jones	Exec. Director, Finance - PAO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	8,500	8,500	-		-	Emp. Stock Option (Right to Buy)
Charles K. Gayer	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	158,500	158,500	-		-	Emp. Stock Option (Right to Buy)
Charles K. Gayer	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	34,000	245,610 (0%)	0%		0	Common Stock
Anthony Doyle	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	158,500	158,500	-		-	Emp. Stock Option (Right to Buy)
Anthony Doyle	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	19 Dec 2022	34,000	197,966 (0%)	0%		0	Common Stock
Jon P. Stonehouse	Director, President & CEO	Sale of securities on an exchange or to another person at price $ 10.90 per share.	15 Dec 2022	14,100	887,730 (0%)	0%	10.9	153,690	Common Stock
Alane Barnes	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 10.88 per share.	15 Dec 2022	4,175	198,770 (0%)	0%	10.9	45,424	Common Stock
Helen M. Thackray	Chief R&D Officer	Sale of securities on an exchange or to another person at price $ 10.89 per share.	15 Dec 2022	3,125	133,275 (0%)	0%	10.9	34,031	Common Stock
Michael L. Jones	Exec. Director, Finance - PAO	Sale of securities on an exchange or to another person at price $ 10.90 per share.	15 Dec 2022	445	10,753 (0%)	0%	10.9	4,851	Common Stock
Charles K. Gayer	Chief Commercial Officer	Sale of securities on an exchange or to another person at price $ 10.90 per share.	15 Dec 2022	6,100	211,610 (0%)	0%	10.9	66,490	Common Stock
Anthony Doyle	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 10.90 per share.	15 Dec 2022	5,700	163,966 (0%)	0%	10.9	62,130	Common Stock
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share.	01 Dec 2022	214,917	1,116,747 (0%)	0%	1.4	305,182	Common Stock
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Dec 2022	82,656	0	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Dec 2022	214,917	82,656	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Sale of securities on an exchange or to another person at price $ 12.80 per share.	01 Dec 2022	82,656	901,830 (0%)	0%	12.8	1,057,997	Common Stock
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share.	01 Dec 2022	82,656	984,486 (0%)	0%	1.4	117,372	Common Stock
Jon P. Stonehouse	Director, President & CEO	Sale of securities on an exchange or to another person at price $ 13.00 per share.	01 Dec 2022	214,917	901,830 (0%)	0%	13	2,793,921	Common Stock
Michael L. Jones	Exec. Director, Finance - PAO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Dec 2022	8,600	0	-		-	Emp. Stock Option (Right to Buy)
Michael L. Jones	Exec. Director, Finance - PAO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share.	01 Dec 2022	8,600	19,798 (0%)	0%	1.4	12,212	Common Stock
Michael L. Jones	Exec. Director, Finance - PAO	Sale of securities on an exchange or to another person at price $ 13.01 per share.	01 Dec 2022	8,600	11,198 (0%)	0%	13.0	111,886	Common Stock
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 13.36 per share.	30 Nov 2022	842	17,714 (0%)	0%	13.4	11,249	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 13.36 per share.	30 Nov 2022	1,497	97,939 (0%)	0%	13.4	20,000	Common Stock
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 13.36 per share.	30 Nov 2022	421	31,191 (0%)	0%	13.4	5,625	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 13.36 per share.	30 Nov 2022	421	31,054 (0%)	0%	13.4	5,625	Common Stock
Yarlagadda S. Babu	Chief Discovery Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share.	14 Nov 2022	50,000	330,056 (0%)	0%	1.4	71,000	Common Stock
Yarlagadda S. Babu	Chief Discovery Officer	Sale of securities on an exchange or to another person at price $ 13.88 per share.	14 Nov 2022	31,515	298,541 (0%)	0%	13.9	437,428	Common Stock
Yarlagadda S. Babu	Chief Discovery Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	14 Nov 2022	50,000	0	-		-	Emp. Stock Option (Right to Buy)
Yarlagadda S. Babu	Chief Discovery Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	14 Nov 2022	50,000	0	-		-	Emp. Stock Option (Right to Buy)
Yarlagadda S. Babu	Chief Discovery Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share.	14 Nov 2022	50,000	280,056 (0%)	0%	1.4	71,000	Common Stock
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 13.90 per share.	31 Aug 2022	809	16,872 (0%)	0%	13.9	11,245	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 13.90 per share.	31 Aug 2022	1,438	96,442 (0%)	0%	13.9	19,988	Common Stock
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 13.90 per share.	31 Aug 2022	404	30,770 (0%)	0%	13.9	5,616	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 13.90 per share.	31 Aug 2022	404	30,633 (0%)	0%	13.9	5,616	Common Stock
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	30,022	30,022	-		-	Automatic Stock Option Grant
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	12,866	16,063 (0%)	0%		0	Common Stock
Kenneth B. Lee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	12,866	37,118 (0%)	0%		0	Common Stock
Kenneth B. Lee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	30,022	30,022	-		-	Automatic Stock Option Grant
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	12,866	77,939 (0%)	0%		0	Common Stock
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	30,022	30,022	-		-	Automatic Stock Option Grant
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	12,866	95,004 (0%)	0%		0	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	30,022	30,022	-		-	Automatic Stock Option Grant
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	30,022	30,022	-		-	Automatic Stock Option Grant
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	12,866	30,366 (0%)	0%		0	Common Stock
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	12,866	46,594 (0%)	0%		0	Common Stock
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	30,022	30,022	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	30,022	30,022	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	12,866	12,866 (0%)	0%		0	Common Stock
Steven Galson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	12,866	12,866 (0%)	0%		0	Common Stock
Steven Galson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	30,022	30,022	-		-	Automatic Stock Option Grant
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	30,022	30,022	-		-	Automatic Stock Option Grant
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	12,866	30,229 (0%)	0%		0	Common Stock
Amy McKee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	30,022	30,022	-		-	Automatic Stock Option Grant
Amy McKee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	07 Jun 2022	12,866	12,866 (0%)	0%		0	Common Stock
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 9.31 per share.	31 May 2022	1,138	3,197 (0%)	0%	9.3	10,595	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 9.31 per share.	31 May 2022	2,078	82,138 (0%)	0%	9.3	19,346	Common Stock
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 9.31 per share.	31 May 2022	569	33,728 (0%)	0%	9.3	5,297	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 9.31 per share.	31 May 2022	1,138	17,363 (0%)	0%	9.3	10,595	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.32 per share.	18 Apr 2022	5,000	5,000 (0%)	0%	3.3	16,600	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	18 Apr 2022	5,000	0	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Sale of securities on an exchange or to another person at price $ 11.04 per share.	18 Apr 2022	5,000	0 (0%)	0%	11.0	55,200	Common Stock
Helen M. Thackray	Chief R&D Officer	Sale of securities on an exchange or to another person at price $ 16.20 per share.	01 Apr 2022	7,600	136,400 (0%)	0%	16.2	123,120	Common Stock
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	10 Mar 2022	148,302	199,093 (0%)	0%	3.2	477,532	Common Stock
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Mar 2022	148,302	0	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 17.64 per share.	10 Mar 2022	1,400	37,954 (0%)	0%	17.6	24,696	Common Stock
William P. Sheridan	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 16.87 per share.	10 Mar 2022	159,739	39,354 (0%)	0%	16.9	2,694,797	Common Stock
Yarlagadda S. Babu	Chief Discovery Officer	Sale of securities on an exchange or to another person at price $ 17.16 per share.	07 Mar 2022	20,000	230,056 (0%)	0%	17.2	343,200	Common Stock
Michael L. Jones	Exec. Director, Finance - PAO	Sale of securities on an exchange or to another person at price $ 17.20 per share.	01 Mar 2022	2,300	11,198 (0%)	0%	17.2	39,560	Common Stock
Michael L. Jones	Exec. Director, Finance - PAO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Mar 2022	2,300	0	-		-	Emp. Stock Option (Right to Buy)
Michael L. Jones	Exec. Director, Finance - PAO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share.	01 Mar 2022	2,300	13,498 (0%)	0%	4.7	10,879	Common Stock
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 16.61 per share.	28 Feb 2022	602	2,059 (0%)	0%	16.6	9,999	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 16.61 per share.	28 Feb 2022	1,128	80,060 (0%)	0%	16.6	18,736	Common Stock
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 16.61 per share.	28 Feb 2022	301	33,159 (0%)	0%	16.6	5,000	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 16.61 per share.	28 Feb 2022	602	16,225 (0%)	0%	16.6	9,999	Common Stock
George B. Abercrombie	Director	Sale of securities on an exchange or to another person at price $ 18.50 per share.	15 Feb 2022	5,000	0 (0%)	0%	18.5	92,500	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2022	5,000	5,000	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.32 per share.	15 Feb 2022	5,000	5,000 (0%)	0%	3.3	16,600	Common Stock
Jon P. Stonehouse	Director, President & CEO	Sale of securities on an exchange or to another person at price $ 15.04 per share.	11 Jan 2022	184,000	901,602 (0%)	0%	15.0	2,767,360	Common Stock
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Jan 2022	184,000	0	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share.	11 Jan 2022	184,000	1,085,602 (0%)	0%	4.7	870,320	Common Stock
Jon P. Stonehouse	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	14 Dec 2021	5,000	783,602 (0%)	0%		0	Common Stock
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	574,500	574,500	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	123,000	901,602 (0%)	0%		0	Common Stock
Jon P. Stonehouse	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	14 Dec 2021	5,000	5,000 (0%)	0%		0	Common Stock
Jon P. Stonehouse	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	14 Dec 2021	5,000	5,000 (0%)	0%		0	Common Stock
Jon P. Stonehouse	Director, President & CEO	Gift of securities by or to the insider at price $ 0.00 per share.	14 Dec 2021	5,000	778,602 (0%)	0%		0	Common Stock
William P. Sheridan	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	164,000	164,000	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	35,000	50,791 (0%)	0%		0	Common Stock
Yarlagadda S. Babu	Chief Discovery Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	164,000	164,000	-		-	Emp. Stock Option (Right to Buy)
Yarlagadda S. Babu	Chief Discovery Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	35,000	250,056 (0%)	0%		0	Common Stock
Alane Barnes	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	75,000	221,969 (0%)	0%		0	Common Stock
Alane Barnes	Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	164,000	164,000	-		-	Emp. Stock Option (Right to Buy)
Helen M. Thackray	Chief R&D Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	44,000	144,000 (0%)	0%		0	Common Stock
Helen M. Thackray	Chief R&D Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	205,000	205,000	-		-	Emp. Stock Option (Right to Buy)
Michael L. Jones	Exec. Director, Finance - PAO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	11,700	11,700	-		-	Emp. Stock Option (Right to Buy)
Michael L. Jones	Exec. Director, Finance - PAO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	5,850	11,198 (0%)	0%		0	Common Stock
Charles K. Gayer	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	125,000	261,556 (0%)	0%		0	Common Stock
Charles K. Gayer	Chief Commercial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	164,000	164,000	-		-	Emp. Stock Option (Right to Buy)
Anthony Doyle	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	164,000	164,000	-		-	Emp. Stock Option (Right to Buy)
Anthony Doyle	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Dec 2021	115,000	208,719 (0%)	0%		0	Common Stock
Yarlagadda S. Babu	Chief Discovery Officer	Sale of securities on an exchange or to another person at price $ 12.20 per share.	07 Dec 2021	30,100	215,056 (0%)	0%	12.2	367,220	Common Stock
Yarlagadda S. Babu	Chief Discovery Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Dec 2021	62,000	0	-		-	Emp. Stock Option (Right to Buy)
Yarlagadda S. Babu	Chief Discovery Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share.	07 Dec 2021	62,000	245,156 (0%)	0%	4.7	293,260	Common Stock
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 12.06 per share.	30 Nov 2021	829	1,457 (0%)	0%	12.1	9,998	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 12.06 per share.	30 Nov 2021	1,554	78,932 (0%)	0%	12.1	18,741	Common Stock
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 12.06 per share.	30 Nov 2021	414	32,858 (0%)	0%	12.1	4,993	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 12.06 per share.	30 Nov 2021	829	15,623 (0%)	0%	12.1	9,998	Common Stock
Vincent J. Milano	Director	Purchase of securities on an exchange or from another person at price $ 12.19 per share.	24 Nov 2021	7,500	17,500 (0%)	0%	12.2	91,425	Common Stock
Anthony Doyle	Chief Financial Officer	Purchase of securities on an exchange or from another person at price $ 12.48 per share.	23 Nov 2021	35,258	93,719 (0%)	0%	12.5	440,020	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.32 per share.	15 Nov 2021	5,000	5,000 (0%)	0%	3.3	16,600	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Nov 2021	5,000	10,000	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Sale of securities on an exchange or to another person at price $ 12.27 per share.	15 Nov 2021	5,000	0 (0%)	0%	12.3	61,350	Common Stock
Nancy J. Hutson	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Oct 2021	30,000	0	-		-	Automatic Stock Option Grant
Nancy J. Hutson	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Oct 2021	30,000	0	-		-	Automatic Stock Option Grant
Nancy J. Hutson	Director	Sale of securities on an exchange or to another person at price $ 15.40 per share.	15 Oct 2021	105,000	65,073 (0%)	0%	15.4	1,617,000	Common Stock
Nancy J. Hutson	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	15 Oct 2021	30,000	170,073 (0%)	0%	3.2	96,600	Common Stock
Nancy J. Hutson	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.71 per share.	15 Oct 2021	15,000	140,073 (0%)	0%	1.7	25,650	Common Stock
Nancy J. Hutson	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.13 per share.	15 Oct 2021	30,000	125,073 (0%)	0%	5.1	153,900	Common Stock
Nancy J. Hutson	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.91 per share.	15 Oct 2021	30,000	95,073 (0%)	0%	2.9	87,300	Common Stock
Nancy J. Hutson	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Oct 2021	30,000	0	-		-	Automatic Stock Option Grant
Nancy J. Hutson	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Oct 2021	15,000	0	-		-	Automatic Stock Option Grant
Amy McKee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Sep 2021	53,333	53,333	-		-	Non-Qualified Stock Option
George B. Abercrombie	Director	Sale of securities on an exchange or to another person at price $ 15.06 per share.	15 Sep 2021	5,000	0 (0%)	0%	15.1	75,300	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Sep 2021	5,000	0	-		-	Non-Qualified Stock Option
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.63 per share.	15 Sep 2021	5,000	5,000 (0%)	0%	2.6	13,150	Common Stock
Kenneth B. Lee	Director	Sale of securities on an exchange or to another person at price $ 15.35 per share.	13 Sep 2021	6,000	24,252 (0%)	0%	15.4	92,100	Common Stock
Kenneth B. Lee	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	13 Sep 2021	15,000	0	-		-	Automatic Stock Option Grant
Kenneth B. Lee	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	13 Sep 2021	15,000	30,252 (0%)	0%	3.2	48,300	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	10 Sep 2021	30,000	44,000 (0%)	0%	3.2	96,600	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Sep 2021	30,000	0	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Sep 2021	30,000	0	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Sep 2021	11,000	0	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Sale of securities on an exchange or to another person at price $ 15.09 per share.	10 Sep 2021	74,000	0 (0%)	0%	15.1	1,116,660	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.91 per share.	10 Sep 2021	30,000	74,000 (0%)	0%	2.9	87,300	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.71 per share.	10 Sep 2021	11,000	14,000 (0%)	0%	1.7	18,810	Common Stock
Steven Galson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Sep 2021	60,000	60,000	-		-	Non-Qualified Stock Option
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 15.92 per share.	31 Aug 2021	628	628 (0%)	0%	15.9	9,998	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 15.92 per share.	31 Aug 2021	1,177	77,378 (0%)	0%	15.9	18,738	Common Stock
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 15.92 per share.	31 Aug 2021	314	32,444 (0%)	0%	15.9	4,999	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 15.92 per share.	31 Aug 2021	628	14,794 (0%)	0%	15.9	9,998	Common Stock
Vincent J. Milano	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Jul 2021	66,667	66,667	-		-	Non-Qualified Stock Option
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.63 per share.	15 Jul 2021	5,000	8,000 (0%)	0%	2.6	13,150	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Jul 2021	5,000	5,000	-		-	Non-Qualified Stock Option
George B. Abercrombie	Director	Sale of securities on an exchange or to another person at price $ 15.69 per share.	15 Jul 2021	5,000	3,000 (0%)	0%	15.7	78,450	Common Stock
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 15.77 per share.	28 May 2021	317	65,073 (0%)	0%	15.8	4,999	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 15.77 per share.	28 May 2021	1,188	76,201 (0%)	0%	15.8	18,735	Common Stock
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 15.77 per share.	28 May 2021	634	32,130 (0%)	0%	15.8	9,998	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 15.77 per share.	28 May 2021	317	14,166 (0%)	0%	15.8	4,999	Common Stock
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	27 May 2021	21,614	0	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	27 May 2021	11,099	5,901	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	27 May 2021	35,701	64,299	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	27 May 2021	24,959	21,614	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 15.02 per share.	27 May 2021	91,814	14,475 (0%)	0%	15.0	1,379,046	Common Stock
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.45 per share.	27 May 2021	5,901	106,289 (0%)	0%	5.4	32,160	Common Stock
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.59 per share.	27 May 2021	64,299	100,388 (0%)	0%	5.6	359,431	Common Stock
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share.	27 May 2021	21,614	36,089 (0%)	0%	4.7	102,234	Common Stock
William P. Sheridan	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 15.00 per share.	27 May 2021	71,759	14,475 (0%)	0%	15	1,076,385	Common Stock
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.45 per share.	27 May 2021	11,099	86,234 (0%)	0%	5.5	60,490	Common Stock
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.59 per share.	27 May 2021	35,701	75,135 (0%)	0%	5.6	199,569	Common Stock
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share.	27 May 2021	24,959	39,434 (0%)	0%	4.7	118,056	Common Stock
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	27 May 2021	64,299	0	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	27 May 2021	5,901	0	-		-	Emp. Stock Option (Right to Buy)
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 May 2021	40,000	40,000	-		-	Automatic Stock Option Grant
Kenneth B. Lee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 May 2021	40,000	40,000	-		-	Automatic Stock Option Grant
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 May 2021	40,000	40,000	-		-	Automatic Stock Option Grant
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 May 2021	40,000	40,000	-		-	Automatic Stock Option Grant
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 May 2021	40,000	40,000	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 May 2021	40,000	40,000	-		-	Automatic Stock Option Grant
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	25 May 2021	40,000	40,000	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	24 May 2021	6,667	10,000	-		-	Non-Qualified Stock Option
George B. Abercrombie	Director	Sale of securities on an exchange or to another person at price $ 13.90 per share.	24 May 2021	6,667	3,000 (0%)	0%	13.9	92,671	Common Stock
George B. Abercrombie	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 2.63 per share.	24 May 2021	6,667	9,667 (0%)	0%	2.6	17,534	Common Stock
Alane Barnes	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.45 per share.	11 May 2021	68,000	213,055 (0%)	0%	5.5	370,600	Common Stock
Alane Barnes	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share.	11 May 2021	33,132	145,055 (0%)	0%	1.4	47,047	Common Stock
Alane Barnes	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 May 2021	35,852	0	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 May 2021	68,000	0	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 May 2021	33,132	0	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 May 2021	1,648	35,852	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share.	11 May 2021	35,852	146,127 (0%)	0%	4.7	169,580	Common Stock
Alane Barnes	Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 12.04 per share.	11 May 2021	102,780	110,275 (0%)	0%	12.0	1,237,471	Common Stock
Alane Barnes	Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.73 per share.	11 May 2021	1,648	111,923 (0%)	0%	4.7	7,795	Common Stock
George B. Abercrombie	Director	Sale of securities on an exchange or to another person at price $ 12.70 per share.	10 May 2021	7,000	3,000 (0%)	0%	12.7	88,900	Common Stock
Helen M. Thackray	Director, Chief R&D Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Mar 2021	400,000	400,000	-		-	Emp. Stock Option (Right to Buy)
Helen M. Thackray	Director, Chief R&D Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	31 Mar 2021	100,000	100,000 (0%)	0%		0	Common Stock
Michael L. Jones	Exec. Director, Finance - PAO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	18 Mar 2021	4,500	0	-		-	Emp. Stock Option (Right to Buy)
Michael L. Jones	Exec. Director, Finance - PAO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.51 per share.	18 Mar 2021	4,500	5,348 (0%)	0%	3.5	15,795	Common Stock
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 10.78 per share.	26 Feb 2021	463	64,756 (0%)	0%	10.8	4,991	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 10.78 per share.	26 Feb 2021	1,739	75,013 (0%)	0%	10.8	18,746	Common Stock
Stephen J. Aselage	Director	Grant, award, or other acquisition of securities at price $ 10.78 per share.	26 Feb 2021	927	31,496 (0%)	0%	10.8	9,993	Common Stock
Theresa M. Heggie	Director	Grant, award, or other acquisition of securities at price $ 10.78 per share.	26 Feb 2021	463	13,849 (0%)	0%	10.8	4,991	Common Stock
William P. Sheridan	Senior VP - CMO	Sale of securities on an exchange or to another person at price $ 11.57 per share.	22 Feb 2021	41,250	11,475 (0%)	0%	11.6	477,263	Common Stock
William P. Sheridan	Senior VP - CMO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	22 Feb 2021	41,250	0	-		-	Stock Option (Right to Buy)
William P. Sheridan	Senior VP - CMO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.15 per share.	22 Feb 2021	41,250	52,725 (0%)	0%	4.2	171,188	Common Stock
Yarlagadda S. Babu	Senior VP - Drug Discovery	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.15 per share.	19 Feb 2021	50,000	205,587 (0%)	0%	4.2	207,500	Common Stock
Yarlagadda S. Babu	Senior VP - Drug Discovery	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Feb 2021	50,000	0	-		-	Stock Option (Right to Buy)
Yarlagadda S. Babu	Senior VP - Drug Discovery	Payment of exercise price or tax liability using portion of securities received from the company at price $ 11.53 per share.	19 Feb 2021	22,431	183,156 (0%)	0%	11.5	258,629	Common Stock
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.15 per share.	15 Dec 2020	134,278	918,364 (0%)	0%	4.2	557,254	Common Stock
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Dec 2020	870,000	870,000	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Dec 2020	134,278	1	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Sale of securities on an exchange or to another person at price $ 8.32 per share.	15 Dec 2020	134,278	784,086 (0%)	0%	8.3	1,117,193	Common Stock
William P. Sheridan	Senior VP - CMO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Dec 2020	335,000	335,000	-		-	Emp. Stock Option (Right to Buy)
Yarlagadda S. Babu	Senior VP - Drug Discovery	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Dec 2020	280,000	280,000	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Senior VP, Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Dec 2020	280,000	280,000	-		-	Emp. Stock Option (Right to Buy)
Megan Sniecinski	Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Dec 2020	225,000	225,000	-		-	Emp. Stock Option (Right to Buy)
Michael L. Jones	Exec. Director, Finance - PAO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Dec 2020	30,000	30,000	-		-	Emp. Stock Option (Right to Buy)
Charles K. Gayer	Vice President and CCO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Dec 2020	190,000	190,000	-		-	Emp. Stock Option (Right to Buy)
Anthony Doyle	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Dec 2020	332,500	332,500	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Senior VP, Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 7.96 per share.	11 Dec 2020	13,741	108,061 (0%)	0%	8.0	109,378	Common Stock
Alane Barnes	Senior VP, Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Dec 2020	13,741	0	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Senior VP, Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.15 per share.	11 Dec 2020	13,741	121,802 (0%)	0%	4.1	57,025	Common Stock
Alane Barnes	Senior VP, Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 6.23 per share.	04 Dec 2020	13,741	108,061 (0%)	0%	6.2	85,606	Common Stock
Alane Barnes	Senior VP, Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	04 Dec 2020	13,741	13,741	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Senior VP, Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.15 per share.	04 Dec 2020	13,741	121,802 (0%)	0%	4.1	57,025	Common Stock
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Dec 2020	157,250	157,250	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Dec 2020	25,000	25,000	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Senior VP - CMO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Dec 2020	17,000	17,000	-		-	Emp. Stock Option (Right to Buy)
Yarlagadda S. Babu	Senior VP - Drug Discovery	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Dec 2020	17,000	17,000	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Senior VP, Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Dec 2020	17,000	17,000	-		-	Emp. Stock Option (Right to Buy)
Michael L. Jones	Exec. Director, Finance - PAO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Dec 2020	5,000	5,000	-		-	Emp. Stock Option (Right to Buy)
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 5.11 per share.	30 Nov 2020	978	64,293 (0%)	0%	5.1	4,998	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 5.11 per share.	30 Nov 2020	3,669	73,274 (0%)	0%	5.1	18,749	Common Stock
Stephen Aselage	Director	Grant, award, or other acquisition of securities at price $ 5.11 per share.	30 Nov 2020	1,956	30,569 (0%)	0%	5.1	9,995	Common Stock
Theresa Heggie	Director	Grant, award, or other acquisition of securities at price $ 5.11 per share.	30 Nov 2020	978	13,386 (0%)	0%	5.1	4,998	Common Stock
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 4.15 per share.	31 Aug 2020	1,204	63,315 (0%)	0%	4.2	4,997	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 4.15 per share.	31 Aug 2020	4,518	69,605 (0%)	0%	4.2	18,750	Common Stock
Stephen Aselage	Director	Grant, award, or other acquisition of securities at price $ 4.15 per share.	31 Aug 2020	2,409	28,613 (0%)	0%	4.1	9,997	Common Stock
Theresa Heggie	Director	Grant, award, or other acquisition of securities at price $ 4.15 per share.	31 Aug 2020	1,204	12,408 (0%)	0%	4.2	4,997	Common Stock
Anthony Doyle	Chief Financial Officer	Purchase of securities on an exchange or from another person at price $ 4.08 per share.	11 Aug 2020	54,000	54,000 (0%)	0%	4.1	220,320	Common Stock
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 4.50 per share.	01 Jun 2020	2,224	62,111 (0%)	0%	4.5	9,997	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 4.50 per share.	01 Jun 2020	4,171	65,087 (0%)	0%	4.5	18,749	Common Stock
Stephen Aselage	Director	Grant, award, or other acquisition of securities at price $ 4.49 per share.	01 Jun 2020	1,112	26,204 (0%)	0%	4.5	4,998	Common Stock
Theresa Heggie	Director	Grant, award, or other acquisition of securities at price $ 4.49 per share.	01 Jun 2020	1,112	11,204 (0%)	0%	4.5	4,998	Common Stock
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 May 2020	157,250	157,250	-		-	Emp. Stock Option (Right to Buy)
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 May 2020	40,000	40,000	-		-	Automatic Stock Option Grant
Kenneth B. Lee	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 May 2020	40,000	40,000	-		-	Automatic Stock Option Grant
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 May 2020	40,000	40,000	-		-	Automatic Stock Option Grant
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 May 2020	40,000	40,000	-		-	Automatic Stock Option Grant
Stephen Aselage	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 May 2020	40,000	40,000	-		-	Automatic Stock Option Grant
George B. Abercrombie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 May 2020	40,000	40,000	-		-	Automatic Stock Option Grant
Helen M. Thackray	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 May 2020	40,000	40,000	-		-	Automatic Stock Option Grant
Theresa Heggie	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	12 May 2020	40,000	40,000	-		-	Automatic Stock Option Grant
Anthony Doyle	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	30 Apr 2020	600,000	600,000	-		-	Emp. Stock Option (Right to Buy)
Nancy J. Hutson	Director	Grant, award, or other acquisition of securities at price $ 3.00 per share.	01 Mar 2020	3,333	59,887 (0%)	0%	3	9,999	Common Stock
Robert Alexander Ingram	Director	Grant, award, or other acquisition of securities at price $ 3.00 per share.	01 Mar 2020	6,250	60,916 (0%)	0%	3	18,750	Common Stock
Stephen Aselage	Director	Grant, award, or other acquisition of securities at price $ 3.00 per share.	01 Mar 2020	1,666	25,092 (0%)	0%	3	4,998	Common Stock
Theresa Heggie	Director	Grant, award, or other acquisition of securities at price $ 3.00 per share.	01 Mar 2020	1,666	10,092 (0%)	0%	3	4,998	Common Stock
Alan G. Levin	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2020	15,000	15,000	-		-	Non-Qualified Stock Option
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2020	27,140	27,140	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2020	18,000	18,000	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Senior VP - CMO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2020	22,600	22,600	-		-	Emp. Stock Option (Right to Buy)
Yarlagadda S. Babu	Senior VP - Drug Discovery	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2020	18,000	18,000	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Senior VP, Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2020	12,400	12,400	-		-	Emp. Stock Option (Right to Buy)
Michael L. Jones	Exec. Director, Finance - PAO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 Feb 2020	2,800	2,800	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Feb 2020	47,495	47,495	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Feb 2020	31,500	31,500	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Senior VP - CMO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Feb 2020	39,550	39,550	-		-	Emp. Stock Option (Right to Buy)
Yarlagadda S. Babu	Senior VP - Drug Discovery	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Feb 2020	31,500	31,500	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Senior VP, Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Feb 2020	21,700	21,700	-		-	Emp. Stock Option (Right to Buy)
Michael L. Jones	Exec. Director, Finance - PAO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	14 Feb 2020	4,900	4,900	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Dec 2019	314,500	314,500	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Dec 2019	127,000	127,000	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Senior VP - CMO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Dec 2019	176,000	176,000	-		-	Emp. Stock Option (Right to Buy)
Yarlagadda S. Babu	Senior VP - Drug Discovery	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Dec 2019	225,000	225,000	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Senior VP, Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Dec 2019	190,000	190,000	-		-	Emp. Stock Option (Right to Buy)
Megan Sniecinski	Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Dec 2019	240,000	240,000	-		-	Emp. Stock Option (Right to Buy)
Nancy J. Hutson	None	Grant, award, or other acquisition of securities at price $ 2.85 per share.	01 Dec 2019	3,508	56,554 (0%)	0%	2.9	9,998	Common Stock
Robert Alexander Ingram	None	Grant, award, or other acquisition of securities at price $ 2.85 per share.	01 Dec 2019	6,578	54,666 (0%)	0%	2.8	18,747	Common Stock
Stephen Aselage	None	Grant, award, or other acquisition of securities at price $ 2.85 per share.	01 Dec 2019	1,754	23,426 (0%)	0%	2.9	4,999	Common Stock
Theresa Heggie	None	Grant, award, or other acquisition of securities at price $ 2.85 per share.	01 Dec 2019	1,754	8,426 (0%)	0%	2.9	4,999	Common Stock
Kenneth B. Lee	None	Purchase of securities on an exchange or from another person at price $ 1.45 per share.	18 Nov 2019	5,000	15,252 (0%)	0%	1.5	7,250	Common Stock
Jon P. Stonehouse	Director, President & CEO	Purchase of securities on an exchange or from another person at price $ 1.45 per share.	18 Nov 2019	50,000	778,086 (0%)	0%	1.5	72,500	Common Stock
Nancy J. Hutson	None	Purchase of securities on an exchange or from another person at price $ 1.45 per share.	18 Nov 2019	10,000	53,046 (0%)	0%	1.5	14,500	Common Stock
Robert Alexander Ingram	None	Purchase of securities on an exchange or from another person at price $ 1.45 per share.	18 Nov 2019	20,000	48,088 (0%)	0%	1.5	29,000	Common Stock
Stephen Aselage	None	Purchase of securities on an exchange or from another person at price $ 1.45 per share.	18 Nov 2019	15,000	21,672 (0%)	0%	1.5	21,750	Common Stock
Yarlagadda S. Babu	Senior VP - Drug Discovery	Purchase of securities on an exchange or from another person at price $ 1.45 per share.	18 Nov 2019	25,000	155,587 (0%)	0%	1.5	36,250	Common Stock
Alane Barnes	Senior VP, Chief Legal Officer	Purchase of securities on an exchange or from another person at price $ 1.45 per share.	18 Nov 2019	20,000	102,061 (0%)	0%	1.5	29,000	Common Stock
Theresa Heggie	None	Purchase of securities on an exchange or from another person at price $ 1.45 per share.	18 Nov 2019	5,000	6,672 (0%)	0%	1.5	7,250	Common Stock
Megan Sniecinski	Chief Business Officer	Purchase of securities on an exchange or from another person at price $ 1.45 per share.	18 Nov 2019	45,000	45,000 (0%)	0%	1.5	65,250	Common Stock
Helen M. Thackray	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Sep 2019	40,000	40,000	-		-	Non-Qualified Stock Option
Nancy J. Hutson	None	Grant, award, or other acquisition of securities at price $ 2.99 per share.	01 Sep 2019	3,344	43,046 (0%)	0%	3.0	9,999	Common Stock
Robert Alexander Ingram	None	Grant, award, or other acquisition of securities at price $ 2.99 per share.	01 Sep 2019	6,270	28,088 (0%)	0%	3.0	18,747	Common Stock
Stephen Aselage	None	Grant, award, or other acquisition of securities at price $ 2.99 per share.	01 Sep 2019	1,672	6,672 (0%)	0%	3.0	4,999	Common Stock
Theresa Heggie	None	Grant, award, or other acquisition of securities at price $ 2.99 per share.	01 Sep 2019	1,672	1,672 (0%)	0%	3.0	4,999	Common Stock
Megan Sniecinski	Chief Business Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Jul 2019	500,000	500,000	-		-	Emp. Stock Option (Right to Buy)
Kenneth B. Lee	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2019	30,000	30,000	-		-	Automatic Stock Option Grant
Nancy J. Hutson	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2019	30,000	30,000	-		-	Automatic Stock Option Grant
Robert Alexander Ingram	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2019	30,000	30,000	-		-	Automatic Stock Option Grant
Stephen Aselage	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2019	30,000	30,000	-		-	Automatic Stock Option Grant
George B. Abercrombie	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2019	30,000	30,000	-		-	Automatic Stock Option Grant
Theresa Heggie	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2019	30,000	30,000	-		-	Automatic Stock Option Grant
Stephen Aselage	None	Purchase of securities on an exchange or from another person at price $ 3.57 per share.	22 May 2019	3,000	5,000 (0%)	0%	3.6	10,710	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Sale of securities on an exchange or to another person at price $ 7.72 per share.	16 May 2019	7,250	127,676 (0%)	0%	7.7	55,970	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 May 2019	4,750	61,000	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Sale of securities on an exchange or to another person at price $ 7.45 per share.	16 May 2019	2,500	125,176 (0%)	0%	7.5	18,625	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share.	16 May 2019	4,750	134,926 (0%)	0%	1.4	6,745	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Sale of securities on an exchange or to another person at price $ 7.62 per share.	14 May 2019	4,500	132,676 (0%)	0%	7.6	34,290	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	14 May 2019	4,750	65,750	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	14 May 2019	4,500	70,500	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Sale of securities on an exchange or to another person at price $ 7.92 per share.	14 May 2019	7,250	130,176 (0%)	0%	7.9	57,420	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share.	14 May 2019	4,750	137,426 (0%)	0%	1.4	6,745	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share.	14 May 2019	4,500	137,176 (0%)	0%	1.4	6,390	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.51 per share.	09 May 2019	9,750	142,426 (0%)	0%	5.5	53,723	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.51 per share.	09 May 2019	9,750	142,426 (0%)	0%	5.5	53,723	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Sale of securities on an exchange or to another person at price $ 7.63 per share.	09 May 2019	9,750	132,676 (0%)	0%	7.6	74,393	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Sale of securities on an exchange or to another person at price $ 7.76 per share.	09 May 2019	9,750	132,676 (0%)	0%	7.8	75,660	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 May 2019	9,750	141,000	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 May 2019	9,750	131,250	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.51 per share.	02 May 2019	7,750	140,426 (0%)	0%	5.5	42,703	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 May 2019	9,000	150,750	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 May 2019	7,750	159,750	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Sale of securities on an exchange or to another person at price $ 7.75 per share.	02 May 2019	9,000	132,676 (0%)	0%	7.8	69,750	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.51 per share.	02 May 2019	9,000	141,676 (0%)	0%	5.5	49,590	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Sale of securities on an exchange or to another person at price $ 7.30 per share.	02 May 2019	7,750	132,676 (0%)	0%	7.3	56,575	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.51 per share.	04 Apr 2019	7,500	140,176 (0%)	0%	5.5	41,325	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	04 Apr 2019	7,500	167,500	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Sale of securities on an exchange or to another person at price $ 8.81 per share.	04 Apr 2019	7,500	132,676 (0%)	0%	8.8	66,075	Common Stock
Stephen Aselage	None	Purchase of securities on an exchange or from another person at price $ 8.30 per share.	12 Mar 2019	2,000	2,000 (0%)	0%	8.3	16,600	Common Stock
Yarlagadda S. Babu	Senior VP - Drug Discovery	Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.68 per share.	31 Jan 2019	7,702	120,084 (0%)	0%	8.7	66,853	Common Stock
Yarlagadda S. Babu	Senior VP - Drug Discovery	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 Jan 2019	12,188	0	-		-	Emp. Stock Option (Right to Buy)
Yarlagadda S. Babu	Senior VP - Drug Discovery	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	31 Jan 2019	19,686	0	-		-	Non-Qualified Stock Option
Yarlagadda S. Babu	Senior VP - Drug Discovery	Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.68 per share.	31 Jan 2019	1,685	130,587 (0%)	0%	8.7	14,626	Common Stock
Yarlagadda S. Babu	Senior VP - Drug Discovery	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.20 per share.	31 Jan 2019	12,188	132,272 (0%)	0%	1.2	14,626	Common Stock
Yarlagadda S. Babu	Senior VP - Drug Discovery	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.20 per share.	31 Jan 2019	19,686	127,786 (0%)	0%	1.2	23,623	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Sale of securities on an exchange or to another person at price $ 9.85 per share.	28 Jan 2019	5,000	128,426 (0%)	0%	9.9	49,250	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Jan 2019	5,000	7,000	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.45 per share.	28 Jan 2019	5,000	133,426 (0%)	0%	5.5	27,250	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	25 Jan 2019	4,000	4,000 (0%)	0%	3.2	12,880	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Jan 2019	2,000	79,427	-		-	Emp. Stock Option (Right to Buy)
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Jan 2019	4,000	81,427	-		-	Emp. Stock Option (Right to Buy)
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	25 Jan 2019	6,000	85,427	-		-	Emp. Stock Option (Right to Buy)
Lynne Powell	Senior VP - CCO	Sale of securities on an exchange or to another person at price $ 9.91 per share.	25 Jan 2019	2,000	0 (0%)	0%	9.9	19,820	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	25 Jan 2019	2,000	2,000 (0%)	0%	3.2	6,440	Common Stock
Lynne Powell	Senior VP - CCO	Sale of securities on an exchange or to another person at price $ 9.88 per share.	25 Jan 2019	4,000	0 (0%)	0%	9.9	39,520	Common Stock
Lynne Powell	Senior VP - CCO	Sale of securities on an exchange or to another person at price $ 9.60 per share.	25 Jan 2019	6,000	0 (0%)	0%	9.6	57,600	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	25 Jan 2019	6,000	6,000 (0%)	0%	3.2	19,320	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	18 Jan 2019	2,000	91,427	-		-	Emp. Stock Option (Right to Buy)
Lynne Powell	Senior VP - CCO	Sale of securities on an exchange or to another person at price $ 9.40 per share.	18 Jan 2019	2,000	0 (0%)	0%	9.4	18,800	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	18 Jan 2019	2,000	2,000 (0%)	0%	3.2	6,440	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	16 Jan 2019	3,046	3,046 (0%)	0%	3.2	9,808	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Jan 2019	3,046	93,427	-		-	Emp. Stock Option (Right to Buy)
Lynne Powell	Senior VP - CCO	Sale of securities on an exchange or to another person at price $ 9.27 per share.	16 Jan 2019	3,046	0 (0%)	0%	9.3	28,236	Common Stock
Lynne Powell	Senior VP - CCO	Sale of securities on an exchange or to another person at price $ 9.20 per share.	14 Jan 2019	954	0 (0%)	0%	9.2	8,777	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	14 Jan 2019	954	96,473	-		-	Emp. Stock Option (Right to Buy)
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	14 Jan 2019	954	954 (0%)	0%	3.2	3,072	Common Stock
Stephen Aselage	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	04 Jan 2019	25,000	25,000	-		-	Non-Qualified Stock Option
Jon P. Stonehouse	Director, President & CEO	Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.07 per share.	01 Jan 2019	3,568	724,106 (0%)	0%	8.1	28,794	Common Stock
Thomas R. Staab	Senior Vice President and CFO	Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.07 per share.	01 Jan 2019	785	132,676 (0%)	0%	8.1	6,335	Common Stock
William P. Sheridan	Senior VP - CMO	Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.07 per share.	01 Jan 2019	1,087	1,638 (0%)	0%	8.1	8,772	Common Stock
Yarlagadda S. Babu	Senior VP - Drug Discovery	Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.07 per share.	01 Jan 2019	771	108,100 (0%)	0%	8.1	6,222	Common Stock
Alane Barnes	Senior VP, Chief Legal Officer	Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.07 per share.	01 Jan 2019	423	77,530 (0%)	0%	8.1	3,414	Common Stock
Jon P. Stonehouse	Director, President & CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Dec 2018	675,000	675,000	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Dec 2018	235,000	235,000	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Senior VP - CMO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Dec 2018	335,000	335,000	-		-	Emp. Stock Option (Right to Buy)
Yarlagadda S. Babu	Senior VP - Drug Discovery	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Dec 2018	235,000	235,000	-		-	Emp. Stock Option (Right to Buy)
Alane Barnes	Senior VP, Chief Legal Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Dec 2018	190,000	190,000	-		-	Emp. Stock Option (Right to Buy)
Lynne Powell	Senior VP - CCO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Dec 2018	190,000	190,000	-		-	Emp. Stock Option (Right to Buy)
William P. Sheridan	Senior VP - CMO	Sale of securities on an exchange or to another person at price $ 7.58 per share.	18 Dec 2018	20,488	2,725 (0%)	0%	7.6	155,299	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	10 Dec 2018	2,000	2,000 (0%)	0%	3.2	6,440	Common Stock
Lynne Powell	Senior VP - CCO	Sale of securities on an exchange or to another person at price $ 9.01 per share.	10 Dec 2018	2,000	0 (0%)	0%	9.0	18,020	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.22 per share.	10 Dec 2018	2,000	2,000 (0%)	0%	3.2	6,440	Common Stock
Lynne Powell	Senior VP - CCO	Sale of securities on an exchange or to another person at price $ 9.11 per share.	10 Dec 2018	2,000	0 (0%)	0%	9.1	18,220	Common Stock
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Dec 2018	2,000	99,427	-		-	Emp. Stock Option (Right to Buy)
Lynne Powell	Senior VP - CCO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	10 Dec 2018	2,000	97,427	-		-	Emp. Stock Option (Right to Buy)
Thomas R. Staab	Senior Vice President and CFO	Sale of securities on an exchange or to another person at price $ 9.45 per share.	04 Dec 2018	3,922	133,461 (0%)	0%	9.5	37,063	Common Stock
Jon P. Stonehouse	Director, President & CEO	Sale of securities on an exchange or to another person at price $ 9.12 per share.	03 Dec 2018	80,000	727,674 (0%)	0%	9.1	729,600	Common Stock
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	03 Dec 2018	80,000	0	-		-	Emp. Stock Option (Right to Buy)
Jon P. Stonehouse	Director, President & CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.20 per share.	03 Dec 2018	80,000	807,674 (0%)	0%	1.2	96,000	Common Stock
Theresa Heggie	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Dec 2018	30,000	30,000	-		-	Non-Qualified Stock Option
Alane Barnes	Senior VP, Chief Legal Officer	Sale of securities on an exchange or to another person at price $ 9.07 per share.	30 Nov 2018	44,290	77,953 (0%)	0%	9.1	401,710	Common Stock
Alane Barnes	Senior VP, Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.42 per share.	30 Nov 2018	25,000	122,243 (0%)	0%	1.4	35,500	Common Stock
Alane Barnes	Senior VP, Chief Legal Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	30 Nov 2018	25,000	25,000	-		-	Emp. Stock Option (Right to Buy)
Stanley Charles Erck	None	Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.49 per share.	28 Nov 2018	8,333	48,333 (0%)	0%	1.5	12,416	Common Stock
Stanley Charles Erck	None	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Nov 2018	8,333	0	-		-	Non-Qualified Stock Option

*All Values are in $ Million

Client Category: Promoter/ KMP/ Director / Immediate Relatives / Employee / etc
Security Type: Share/ Warrants / Convertible Debentures

Data as reported to USA Exchanges

View All The Insider Trades disclosures

90.82% Gain from 52W Low

Insider Trading disclosures for Biocryst Pharmaceuticals Inc.

The latest disclosure was made by Vincent J. Milano in Biocryst Pharmaceuticals Inc. where a trade of 653 Common Stock done at an average price of $8.6 was reported to US exchanges on Feb. 28, 2025.

Screeners based on Insider Trading and SAST parameters