818.4K XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Jane A. Gross | Director | Purchase of securities on an exchange or from another person at price $ 4.00 per share. | 17 Mar 2025 | 3,750 | 9,750 (0%) | 0% | 4 | 15,000 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 3,750 | 33,017 (0%) | 0% | - | Common Stock | |
| Jill M. Broadfoot | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 3.78 per share. | 03 Feb 2025 | 1,254 | 31,763 (0%) | 0% | 3.8 | 4,740 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 3,750 | 3,750 | - | - | Restricted Stock Unit | |
| Nancy E. Denyes | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 2,687 | 2,687 | - | - | Restricted Stock Unit | |
| Nancy E. Denyes | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 2,687 | 27,454 (0%) | 0% | - | Common Stock | |
| Nancy E. Denyes | General Counsel | Sale of securities on an exchange or to another person at price $ 3.78 per share. | 03 Feb 2025 | 899 | 26,555 (0%) | 0% | 3.8 | 3,398 | Common Stock |
| Sanjay S. Shukla | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 10,375 | 10,375 | - | - | Restricted Stock Unit | |
| Sanjay S. Shukla | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 10,375 | 146,923 (1%) | 0% | - | Common Stock | |
| Benevich S. Eric | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Dec 2024 | 100,000 | 100,000 | - | - | Stock Option (right to buy) | |
| Paul R. Schimmel | Director | Purchase of securities on an exchange or from another person at price $ 1.93 per share. | 22 Jul 2024 | 52,300 | 413,023 (4%) | 0% | 1.9 | 101,038 | Common Stock |
| Paul R. Schimmel | Director | Purchase of securities on an exchange or from another person at price $ 1.82 per share. | 22 Jul 2024 | 6,648 | 360,723 (4%) | 0% | 1.8 | 12,075 | Common Stock |
| Paul R. Schimmel | Director | Purchase of securities on an exchange or from another person at price $ 1.74 per share. | 22 Jul 2024 | 41,052 | 354,075 (4%) | 0% | 1.7 | 71,500 | Common Stock |
| Nancy E. Denyes | General Counsel | Purchase of securities on an exchange or from another person at price $ 1.86 per share. | 05 Jun 2024 | 5,000 | 22,267 (0%) | 0% | 1.9 | 9,276 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 1.79 per share. | 31 May 2024 | 5,000 | 27,960 (0%) | 0% | 1.8 | 8,950 | Common Stock |
| Sanjay S. Shukla | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 1.81 per share. | 31 May 2024 | 20,000 | 136,548 (1%) | 0% | 1.8 | 36,140 | Common Stock |
| Timothy P. Coughlin | Director | Purchase of securities on an exchange or from another person at price $ 1.75 per share. | 30 May 2024 | 50,000 | 56,000 (0%) | 0% | 1.8 | 87,500 | Common Stock |
| Paul R. Schimmel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 24,000 | 24,000 | - | - | Stock Option (right to buy) | |
| John K. Clarke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 24,000 | 24,000 | - | - | Stock Option (right to buy) | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 24,000 | 24,000 | - | - | Stock Option (right to buy) | |
| Sara Zaknoen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 24,000 | 24,000 | - | - | Stock Option (right to buy) | |
| Jane A. Gross | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 24,000 | 24,000 | - | - | Stock Option (right to buy) | |
| Svetlana Lucas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 May 2024 | 24,000 | 24,000 | - | - | Stock Option (right to buy) | |
| Shukla Sanjay S. | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2024 | 10,375 | 116,548 (1%) | 0% | - | Common stock | |
| Shukla S. Sanjay | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2024 | 10,375 | 20,750 | - | - | Restricted Stock Unit | |
| Broadfoot M. Jill | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 1.69 per share. | 05 Feb 2024 | 1,590 | 20,821 (0%) | 0% | 1.7 | 2,687 | Common stock |
| E. Nancy Denyes | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2024 | 2,688 | 5,374 | - | - | Restricted Stock Unit | |
| E. Nancy Denyes | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2024 | 2,688 | 14,767 (0%) | 0% | - | Common stock | |
| Jill M. Broadfoot | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2024 | 3,750 | 7,500 | - | - | Restricted Stock Unit | |
| Jill Broadfoot M. | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2024 | 3,750 | 22,411 (0%) | 0% | - | Common stock | |
| M. Jill Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2024 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| E. Denyes Nancy | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2024 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Sanjay Shukla S. | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jan 2024 | 600,000 | 600,000 | - | - | Employee Stock Option (right to buy) | |
| Sanjay Shukla S. | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 1.17 per share. | 11 Dec 2023 | 3,000 | 94,173 (1%) | 0% | 1.2 | 3,510 | Common Stock |
| Sanjay Shukla S. | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 1.18 per share. | 11 Dec 2023 | 12,000 | 106,173 (1%) | 0% | 1.2 | 14,136 | Common Stock |
| Sanjay Shukla S. | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 1.14 per share. | 10 Nov 2023 | 1,422 | 77,595 (0%) | 0% | 1.1 | 1,618 | Common Stock |
| S. Shukla Sanjay | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 1.11 per share. | 10 Nov 2023 | 13,578 | 91,173 (1%) | 0% | 1.1 | 15,085 | Common Stock |
| Sanjay S. Shukla | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 2.01 per share. | 28 Jul 2023 | 15,000 | 76,173 (0%) | 0% | 2.0 | 30,224 | Common Stock |
| Paul R. Schimmel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 12,000 | 12,000 | - | - | Stock Option (right to buy) | |
| John K. Clarke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 12,000 | 12,000 | - | - | Stock Option (right to buy) | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 12,000 | 12,000 | - | - | Stock Option (right to buy) | |
| Timothy P. Coughlin | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 May 2023 | 6,000 | 6,000 (0%) | 0% | 0 | Common Stock | |
| Timothy P. Coughlin | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 May 2023 | 6,000 | 0 (0%) | 0% | 0 | Common Stock | |
| Sara Zaknoen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 12,000 | 12,000 | - | - | Stock Option (right to buy) | |
| Jane A. Gross | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 12,000 | 12,000 | - | - | Stock Option (right to buy) | |
| Svetlana Lucas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2023 | 12,000 | 12,000 | - | - | Stock Option (right to buy) | |
| Paul R. Schimmel | Director | Purchase of securities on an exchange or from another person at price $ 2.25 per share. | 10 May 2023 | 200,000 | 313,023 (3%) | 2% | 2.3 | 450,000 | Common Stock |
| Paul R. Schimmel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 8,890 (0%) | 0% | - | Common stock | |
| Paul R. Schimmel | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 0 | - | - | Restricted Stock Unit | |
| John K. Clarke | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 0 | - | - | Restricted Stock Unit | |
| John K. Clarke | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 19,797 (0%) | 0% | - | Common Stock | |
| Timothy P. Coughlin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 6,000 (0%) | 0% | - | Common stock | |
| Timothy P. Coughlin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 0 | - | - | Restricted Stock Unit | |
| Sara Zaknoen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 0 | - | - | Restricted Stock Unit | |
| Sara Zaknoen | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 6,000 (0%) | 0% | - | Common stock | |
| Jane A. Gross | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 6,000 (0%) | 0% | - | Common stock | |
| Jane A. Gross | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 0 | - | - | Restricted Stock Unit | |
| Svetlana Lucas | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 6,000 (0%) | 0% | - | Common stock | |
| Svetlana Lucas | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2023 | 6,000 | 0 | - | - | Restricted Stock Unit | |
| Jill M. Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 84,023 | 84,023 | - | - | Employee Stock Option (right to buy) | |
| Nancy E. Denyes | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 84,023 | 84,023 | - | - | Employee Stock Option (right to buy) | |
| Sanjay S. Shukla | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 336,096 | 336,096 | - | - | Employee Stock Option (right to buy) | |
| Jill M. Broadfoot | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 2.36 per share. | 03 Feb 2023 | 1,566 | 15,460 (0%) | 0% | 2.4 | 3,696 | Common stock |
| Jill M. Broadfoot | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2023 | 3,750 | 11,250 | - | - | Restricted Stock Unit | |
| Jill M. Broadfoot | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2023 | 3,750 | 17,026 (0%) | 0% | - | Common stock | |
| Nancy E. Denyes | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2023 | 2,688 | 8,062 | - | - | Restricted Stock Unit | |
| Nancy E. Denyes | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2023 | 2,688 | 7,079 (0%) | 0% | - | Common stock | |
| Sanjay S. Shukla | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2023 | 10,375 | 61,173 (0%) | 0% | - | Common stock | |
| Sanjay S. Shukla | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2023 | 10,375 | 31,125 | - | - | Restricted Stock Unit | |
| Sanjay S. Shukla | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 2.14 per share. | 21 Nov 2022 | 10,000 | 50,798 (0%) | 0% | 2.1 | 21,405 | Common Stock |
| Sanjay S. Shukla | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 2.88 per share. | 01 Jul 2022 | 15,000 | 40,798 (0%) | 0% | 2.9 | 43,164 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2022 | 75,347 | 75,347 | - | - | Employee Stock Option (right to buy) | |
| Nancy E. Denyes | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2022 | 88,097 | 88,097 | - | - | Employee Stock Option (right to buy) | |
| Sanjay S. Shukla | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2022 | 516,280 | 516,280 | - | - | Employee Stock Option (right to buy) | |
| Paul R. Schimmel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 6,000 | 6,000 | - | - | Restricted Stock Units | |
| John K. Clarke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 6,000 | 6,000 | - | - | Restricted Stock Units | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 6,000 | 6,000 | - | - | Restricted Stock Units | |
| Sara Zaknoen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 6,000 | 6,000 | - | - | Restricted Stock Units | |
| Jane A. Gross | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 6,000 | 6,000 | - | - | Restricted Stock Units | |
| Svetlana Lucas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2022 | 6,000 | 6,000 | - | - | Restricted Stock Units | |
| Jill M. Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 30,000 | 30,000 | - | - | Employee Stock Option (right to buy) | |
| Jill M. Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 15,000 | 15,000 | - | - | Restricted Stock Units | |
| Nancy E. Denyes | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 10,750 | 10,750 | - | - | Restricted Stock Units | |
| Nancy E. Denyes | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 21,500 | 21,500 | - | - | Employee Stock Option (right to buy) | |
| Sanjay S. Shukla | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 41,500 | 41,500 | - | - | Restricted Stock Units | |
| Sanjay S. Shukla | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Feb 2022 | 83,000 | 83,000 | - | - | Employee Stock Option (right to buy) | |
| Jill M. Broadfoot | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 6.75 per share. | 13 Jan 2022 | 1,923 | 12,112 (0%) | 0% | 6.7 | 12,980 | Common stock |
| Sanjay S. Shukla | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 6.76 per share. | 07 Jan 2022 | 5,000 | 25,798 (0%) | 0% | 6.8 | 33,807 | Common Stock |
| Sanjay S. Shukla | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 8.58 per share. | 15 Nov 2021 | 2,500 | 20,798 (0%) | 0% | 8.6 | 21,438 | Common Stock |
| Paul R. Schimmel | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 Sep 2021 | 250,000 | 679,143 (7%) | 2% | 0 | Common Stock | |
| Paul R. Schimmel | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 Sep 2021 | 250,000 | 2,890 (0%) | 2% | 0 | Common Stock | |
| Paul R. Schimmel | Director | Purchase of securities on an exchange or from another person at price $ 8.00 per share. | 20 Sep 2021 | 250,000 | 252,890 (2%) | 2% | 8 | 2,000,000 | Common Stock |
| John K. Clarke | Director | Sale of securities on an exchange or to another person at price $ 4.34 per share. | 21 May 2021 | 2,500 | 108,083 (1%) | 0% | 4.3 | 10,850 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2021 | 54,000 | 54,000 | - | - | Employee Stock Option (Right to buy) | |
| Sara Zaknoen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2021 | 2,285 | 2,285 | - | - | Stock Option (right to buy) | |
| Nancy E. Denyes | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2021 | 59,000 | 59,000 | - | - | Employee Stock Option (Right to buy) | |
| Sanjay S. Shukla | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2021 | 207,000 | 207,000 | - | - | Employee Stock Option (Right to buy) | |
| Paul R. Schimmel | Director | Purchase of securities on an exchange or from another person at price $ 3.98 per share. | 18 May 2021 | 50,000 | 113,023 (1%) | 0% | 4.0 | 199,000 | Common Stock |
| Sanjay S. Shukla | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 4.01 per share. | 18 May 2021 | 10,000 | 18,298 (0%) | 0% | 4.0 | 40,100 | Common Stock |
| Paul R. Schimmel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2021 | 1,428 | 1,428 | - | - | Stock Option (right to buy) | |
| John K. Clarke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2021 | 1,428 | 1,428 | - | - | Stock Option (right to buy) | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2021 | 1,428 | 1,428 | - | - | Stock Option (right to buy) | |
| Jane A. Gross | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2021 | 1,428 | 1,428 | - | - | Stock Option (right to buy) | |
| Svetlana Lucas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2021 | 1,428 | 1,428 | - | - | Stock Option (right to buy) | |
| Jill M. Broadfoot | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2021 | 892 | 0 | - | - | Restricted Stock Unit | |
| Jill M. Broadfoot | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2021 | 892 | 10,223 (0%) | 0% | - | Common stock | |
| Jill M. Broadfoot | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 7.66 per share. | 06 Feb 2021 | 390 | 9,833 (0%) | 0% | 7.7 | 2,987 | Common stock |
| Sanjay S. Shukla | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2021 | 1,785 | 0 | - | - | Restricted Stock Unit | |
| Sanjay S. Shukla | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2021 | 1,785 | 9,076 (0%) | 0% | - | Common stock | |
| Sanjay S. Shukla | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 7.66 per share. | 06 Feb 2021 | 778 | 8,298 (0%) | 0% | 7.7 | 5,959 | Common stock |
| Jill M. Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2021 | 50,000 | 50,000 | - | - | Employee Stock Option (right to buy) | |
| Nancy E. Denyes | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2021 | 45,000 | 45,000 | - | - | Employee Stock Option (right to buy) | |
| Sanjay S. Shukla | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Feb 2021 | 112,469 | 112,469 | - | - | Employee Stock Option (right to buy) | |
| John K. Clarke | Director | Sale of securities on an exchange or to another person at price $ 4.01 per share. | 28 Aug 2020 | 7,260 | 110,583 (1%) | 0% | 4.0 | 29,113 | Common Stock |
| John K. Clarke | Director | Sale of securities on an exchange or to another person at price $ 4.00 per share. | 28 Aug 2020 | 100 | 117,843 (1%) | 0% | 4 | 400 | Common Stock |
| John K. Clarke | Director | Sale of securities on an exchange or to another person at price $ 4.30 per share. | 26 Aug 2020 | 2,200 | 123,383 (1%) | 0% | 4.3 | 9,451 | Common Stock |
| John K. Clarke | Director | Sale of securities on an exchange or to another person at price $ 4.09 per share. | 26 Aug 2020 | 5,440 | 117,943 (1%) | 0% | 4.1 | 22,250 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 4.22 per share. | 19 Jun 2020 | 1,850 | 9,153 (0%) | 0% | 4.2 | 7,807 | Common Stock |
| Sanjay S. Shukla | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 4.27 per share. | 19 Jun 2020 | 6,000 | 7,291 (0%) | 0% | 4.3 | 25,620 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2020 | 30,000 | 30,000 | - | - | Employee Stock Option (right to buy) | |
| Sanjay S. Shukla | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2020 | 80,000 | 0 | - | - | Employee Stock Option (right to buy) | |
| Paul R. Schimmel | Director | Sale of securities on an exchange or to another person at price $ 3.64 per share. | 20 May 2020 | 8,447 | 429,143 (5%) | 0% | 3.6 | 30,739 | Common Stock |
| Nancy E. Denyes | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2020 | 892 | 0 | - | - | Restricted Stock Unit | |
| Nancy E. Denyes | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2020 | 892 | 3,057 (0%) | 0% | - | Common Stock | |
| Nancy E. Denyes | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2020 | 30,000 | 30,000 | - | - | Employee Stock Option (right to buy) | |
| Nancy E. Denyes | General Counsel | Sale of securities on an exchange or to another person at price $ 3.62 per share. | 16 May 2020 | 322 | 2,735 (0%) | 0% | 3.6 | 1,166 | Common Stock |
| Paul R. Schimmel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2020 | 1,428 | 1,428 | - | - | Stock Option (right to buy) | |
| John K. Clarke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2020 | 1,428 | 1,428 | - | - | Stock Option (right to buy) | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2020 | 1,428 | 1,428 | - | - | Stock Option (right to buy) | |
| Jeffrey S. Hatfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2020 | 1,428 | 1,428 | - | - | Stock Option (right to buy) | |
| Jane A. Gross | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2020 | 1,428 | 1,428 | - | - | Stock Option (right to buy) | |
| Svetlana Lucas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2020 | 1,428 | 1,428 | - | - | Stock Option (right to buy) | |
| Paul R. Schimmel | Director | Purchase of securities on an exchange or from another person at price $ 4.25 per share. | 10 Feb 2020 | 254,000 | 437,590 (5%) | 2% | 4.3 | 1,079,500 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 4.03 per share. | 05 Feb 2020 | 375 | 7,125 (0%) | 0% | 4.0 | 1,511 | Common stock |
| Jill M. Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2020 | 23,359 | 23,359 | - | - | Employee Stock Option (right to buy) | |
| Jill M. Broadfoot | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2020 | 893 | 7,500 (0%) | 0% | - | Common stock | |
| Jill M. Broadfoot | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2020 | 893 | 893 | - | - | Restricted Stock Unit | |
| Sanjay S. Shukla | President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2020 | 1,786 | 2,036 (0%) | 0% | - | Common stock | |
| Sanjay S. Shukla | President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2020 | 1,786 | 1,786 | - | - | Restricted Stock Unit | |
| Sanjay S. Shukla | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2020 | 39,327 | 39,327 | - | - | Employee Stock Option (right to buy) | |
| Sanjay S. Shukla | President and CEO | Sale of securities on an exchange or to another person at price $ 4.03 per share. | 05 Feb 2020 | 745 | 1,291 (0%) | 0% | 4.0 | 3,002 | Common stock |
| Jane A. Gross | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2019 | 2,285 | 2,285 | - | - | Stock Option (right to buy) | |
| Svetlana Lucas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2019 | 2,285 | 2,285 | - | - | Stock Option (right to buy) | |
| Nancy E. Denyes | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2019 | 12,500 | 12,500 | - | - | Restricted Stock Units | |
| Nancy E. Denyes | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 May 2019 | 12,500 | 29,999 (0%) | 0% | 0 | Common Stock | |
| Nancy E. Denyes | General Counsel | Sale of securities on an exchange or to another person at price $ 0.45 per share. | 16 May 2019 | 4,651 | 25,348 (0%) | 0% | 0.5 | 2,093 | Common Stock |
| James C. Blair | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Paul R. Schimmel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| John K. Clarke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Timothy P. Coughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| John D. Mendlein | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Jeffrey S. Hatfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2019 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Paul R. Schimmel | Director | Grant, award, or other acquisition of securities at price $ 0.54 per share. | 12 Apr 2019 | 1,848,428 | 2,570,242 (30%) | 4% | 0.5 | 1,000,000 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2019 | 25,000 | 25,000 | - | - | Restricted Stock Unit | |
| Jill M. Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2019 | 50,000 | 50,000 | - | - | Employee Stock Option (right to buy) | |
| Nancy E. Denyes | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2019 | 125,000 | 125,000 | - | - | Employee Stock Option (right to buy) | |
| Sanjay S. Shukla | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2019 | 200,000 | 200,000 | - | - | Employee Stock Option (right to buy) | |
| Sanjay S. Shukla | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2019 | 50,000 | 50,000 | - | - | Restricted Stock Unit | |
| Nancy E. Denyes | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2019 | 13,778 | 13,778 | - | - | Employee Stock Option (right to buy) | |
| John D. Mendlein | None | Purchase of securities on an exchange or from another person at price $ 0.41 per share. | 20 Dec 2018 | 50,000 | 420,382 (1%) | 0% | 0.4 | 20,645 | Common Stock |
| John D. Mendlein | None | Purchase of securities on an exchange or from another person at price $ 0.42 per share. | 20 Dec 2018 | 195,000 | 615,382 (2%) | 0% | 0.4 | 82,602 | Common Stock |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.54 per share. | 26 Nov 2018 | 147,225 | 882,302 (2%) | 0% | 0.5 | 79,796 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 0.84 per share. | 19 Sep 2018 | 38,000 | 90,000 (0%) | 0% | 0.8 | 31,738 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 0.81 per share. | 19 Sep 2018 | 26,000 | 52,000 (0%) | 0% | 0.8 | 21,117 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 0.73 per share. | 14 Sep 2018 | 26,000 | 26,000 (0%) | 0% | 0.7 | 19,055 | Common Stock |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.76 per share. | 31 Aug 2018 | 20,749 | 735,077 (2%) | 0% | 0.8 | 15,709 | Common Stock |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.72 per share. | 31 Aug 2018 | 22,000 | 714,328 (2%) | 0% | 0.7 | 15,752 | Common Stock |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.76 per share. | 29 Aug 2018 | 89,275 | 692,328 (2%) | 0% | 0.8 | 67,483 | Common Stock |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.72 per share. | 29 Aug 2018 | 75,136 | 603,053 (2%) | 0% | 0.7 | 54,090 | Common Stock |
| Jill M. Broadfoot | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jul 2018 | 200,000 | 200,000 | - | - | Employee Stock Option (right to buy) | |
| Amanullah Ashraf | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 May 2018 | 3,333 | 26,264 (0%) | 0% | 0 | Common Stock | |
| Amanullah Ashraf | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 May 2018 | 3,333 | 3,333 | - | - | Restricted Stock Units | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 1.00 per share. | 18 May 2018 | 150,000 | 527,917 (1%) | 0% | 1.0 | 149,445 | Common Stock |
| James C. Blair | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2018 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Paul R. Schimmel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2018 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| John K. Clarke | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2018 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Timothy P. Coughlin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2018 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| John D. Mendlein | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2018 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Amir H. Nashat | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2018 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Jeffrey S. Hatfield | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2018 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| John T. Blake | Senior Vice President, Finance | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2018 | 3,334 | 6,666 | - | - | Restricted Stock Units | |
| John T. Blake | Senior Vice President, Finance | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2018 | 3,334 | 3,334 (0%) | 0% | 0 | Common Stock | |
| John T. Blake | Senior Vice President, Finance | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 06 Feb 2018 | 1,402 | 1,932 (0%) | 0% | 3.4 | 4,767 | Common Stock |
| John T. Blake | Senior Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2018 | 75,000 | 75,000 | - | - | Employee Stock Option (right to buy) | |
| Amanullah Ashraf | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2018 | 3,334 | 3,334 (0%) | 0% | 0 | Common Stock | |
| Amanullah Ashraf | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2018 | 3,334 | 6,666 | - | - | Restricted Stock Units | |
| Amanullah Ashraf | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2018 | 100,000 | 100,000 | - | - | Employee Stock Option (right to buy) | |
| Amanullah Ashraf | See Remarks | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 06 Feb 2018 | 1,402 | 1,932 (0%) | 0% | 3.4 | 4,767 | Common Stock |
| Sanjay S. Shukla | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2018 | 300,000 | 300,000 | - | - | Employee Stock Option (right to buy) | |
| David John King | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Feb 2018 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| John D. Mendlein | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jan 2018 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Sanjay S. Shukla | President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2017 | 450,000 | 450,000 | - | - | Employee Stock Option (right to buy) | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 2.65 per share. | 31 Aug 2017 | 94,336 | 377,917 (1%) | 0% | 2.6 | 249,990 | Common Stock |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 31 Aug 2017 | 35,376 | 35,376 | - | - | Warrant to Purchase Common Stock | |
| John D. Mendlein | Director, CEO and Director | Purchase of securities on an exchange or from another person at price $ 2.65 per share. | 31 Aug 2017 | 37,736 | 367,883 (1%) | 0% | 2.6 | 100,000 | Common Stock |
| John D. Mendlein | Director, CEO and Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 31 Aug 2017 | 14,151 | 14,151 | - | - | Warrant to Purchase Common Stock | |
| James C. Blair | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2017 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Mark A. Goldberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2017 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Paul R. Schimmel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2017 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| John K. Clarke | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2017 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Timothy P. Coughlin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2017 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Srinivas Akkaraju | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2017 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Amir H. Nashat | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2017 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Jeffrey S. Hatfield | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2017 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| John D. Mendlein | Director, CEO and Director | Purchase of securities on an exchange or from another person at price $ 3.00 per share. | 24 Apr 2017 | 124 | 327,647 (1%) | 0% | 3 | 372 | Common Stock |
| John D. Mendlein | Director, CEO and Director | Purchase of securities on an exchange or from another person at price $ 3.00 per share. | 18 Apr 2017 | 1,000 | 325,971 (1%) | 0% | 3 | 3,000 | Common Stock |
| John D. Mendlein | Director, CEO and Director | Purchase of securities on an exchange or from another person at price $ 3.00 per share. | 18 Apr 2017 | 1,552 | 327,523 (1%) | 0% | 3 | 4,656 | Common Stock |
| Timothy P. Coughlin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Apr 2017 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| Jeffrey S. Hatfield | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Apr 2017 | 32,000 | 32,000 | - | - | Stock Option (right to buy) | |
| John D. Mendlein | Director, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2017 | 185,000 | 185,000 | - | - | Employee Stock Option (right to buy) | |
| John T. Blake | Senior Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2017 | 10,000 | 10,000 | - | - | Restricted Stock Unit | |
| John T. Blake | Senior Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2017 | 55,000 | 55,000 | - | - | Employee Stock Option (right to buy) | |
| Sanuj K. Ravindran | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2017 | 40,000 | 40,000 | - | - | Employee Stock Option (right to buy) | |
| Amanullah Ashraf | Vice President, Manufacturing | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2017 | 10,000 | 10,000 | - | - | Restricted Stock Unit | |
| Amanullah Ashraf | Vice President, Manufacturing | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2017 | 35,000 | 35,000 | - | - | Employee Stock Option (right to buy) | |
| Grove Matsuoka | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2017 | 20,000 | 20,000 | - | - | Employee Stock Option (right to buy) | |
| Sanjay S. Shukla | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2017 | 65,000 | 65,000 | - | - | Employee Stock Option (right to buy) | |
| David John King | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2017 | 65,000 | 65,000 | - | - | Employee Stock Option (right to buy) | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Dec 2016 | 10,000 | 721,814 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Dec 2016 | 15,000 | 711,814 | - | - | Common Stock | |
| Amanullah Ashraf | Vice President, Manufacturing | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Dec 2016 | 11,000 | 11,000 | - | - | Common Stock | |
| John D. Mendlein | Director, CEO and Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 19 Dec 2016 | 69,000 | 324,971 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 15 Dec 2016 | 40,000 | 686,814 | - | - | Common Stock | |
| Paul R. Schimmel | None | Gift of securities by or to the insider at price $ 0.00 per share. | 15 Dec 2016 | 12,572 | 646,814 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 15 Dec 2016 | 10,000 | 696,814 | - | - | Common Stock | |
| Paul R. Schimmel | None | Gift of securities by or to the insider at price $ 0.00 per share. | 15 Dec 2016 | 12,572 | 40,440 | - | - | Common Stock | |
| David John King | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Sep 2016 | 145,000 | 145,000 | - | - | Employee Stock Option (right to buy) | |
| Andrew Cubitt | VP, Product Protection | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Sep 2016 | 25,000 | 25,000 | - | - | Employee Stock Option (right to buy) | |
| John T. Blake | Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Sep 2016 | 19,000 | 19,000 | - | - | Employee Stock Option (right to buy) | |
| Sanuj K. Ravindran | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Sep 2016 | 45,500 | 45,500 | - | - | Employee Stock Option (right to buy) | |
| Amanullah Ashraf | Vice President, Manufacturing | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Sep 2016 | 28,000 | 28,000 | - | - | Employee Stock Option (right to buy) | |
| Grove Matsuoka | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Sep 2016 | 20,000 | 20,000 | - | - | Employee Stock Option (right to buy) | |
| Sanjay Shukla | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Sep 2016 | 27,500 | 27,500 | - | - | Employee Stock Option (right to buy) | |
| John K. Clarke | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 18,000 | 18,000 | - | - | Stock Option (right to buy) | |
| Paul R. Schimmel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 18,000 | 18,000 | - | - | Stock Option (right to buy) | |
| Kathryn E. Falberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 18,000 | 18,000 | - | - | Stock Option (right to buy) | |
| James C. Blair | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 18,000 | 18,000 | - | - | Stock Option (right to buy) | |
| Srinivas Akkaraju | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 18,000 | 18,000 | - | - | Stock Option (right to buy) | |
| Mark A. Goldberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 18,000 | 18,000 | - | - | Stock Option (right to buy) | |
| Amir H. Nashat | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2016 | 18,000 | 18,000 | - | - | Stock Option (right to buy) | |
| Grove Matsuoka | See Remarks | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 09 May 2016 | 10,000 | 12,412 | - | - | Common Stock | |
| Grove Matsuoka | See Remarks | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 09 May 2016 | 2,412 | 2,412 | - | - | Common Stock | |
| Grove Matsuoka | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 May 2016 | 145,000 | 145,000 | - | - | Stock Option (right to buy) | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Apr 2016 | 33,619 | 283,581 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Apr 2016 | 32,600 | 53,012 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 13 Apr 2016 | 9,835 | 249,962 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 12 Apr 2016 | 6,546 | 240,127 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 12 Apr 2016 | 2,581 | 20,412 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Apr 2016 | 5,259 | 17,831 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Apr 2016 | 22,100 | 233,581 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Apr 2016 | 5,300 | 211,481 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 08 Apr 2016 | 85,000 | 187,572 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 07 Apr 2016 | 40,000 | 102,572 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 06 Apr 2016 | 25,000 | 62,572 | - | - | Common Stock | |
| Paul R. Schimmel | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 05 Apr 2016 | 25,000 | 37,572 | - | - | Common Stock | |
| John D. Mendlein | Director, CEO and Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 05 Apr 2016 | 2,500 | 250,971 | - | - | Common Stock | |
| John D. Mendlein | Director, CEO and Director | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 05 Apr 2016 | 2,500 | 248,471 | - | - | Common Stock | |
| Sanjay Shukla | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Mar 2016 | 163,000 | 163,000 | - | - | Employee Stock Option (right to buy) | |
| Kelly Blackburn | VP, Clinical Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Mar 2016 | 21,600 | 21,600 | - | - | Restricted Stock Unit | |
| Andrew Cubitt | VP, Product Protection | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Mar 2016 | 13,000 | 13,000 | - | - | Restricted Stock Unit | |
| John K. Clarke | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 19,428 | 19,428 | - | - | Stock Option (right to buy) | |
| Paul R. Schimmel | None | Gift of securities by or to the insider at price $ 0.00 per share. | 27 Jan 2016 | 11,925 | 634,242 | - | - | Common Stock | |
| Paul R. Schimmel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 19,428 | 19,428 | - | - | Stock Option (right to buy) | |
| Kathryn E. Falberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 19,428 | 19,428 | - | - | Stock Option (right to buy) | |
| James C. Blair | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 19,428 | 19,428 | - | - | Stock Option (right to buy) | |
| Srinivas Akkaraju | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 19,428 | 19,428 | - | - | Stock Option (right to buy) | |
| Mark A. Goldberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 19,428 | 19,428 | - | - | Stock Option (right to buy) | |
| Amir H. Nashat | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 19,428 | 19,428 | - | - | Stock Option (right to buy) | |
| John D. Mendlein | Director, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 135,000 | 135,000 | - | - | Employee Stock Option (right to buy) | |
| Melissa A. Ashlock | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 18,250 | 18,250 | - | - | Employee Stock Option (right to buy) | |
| John C. McKew | VP, Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 40,000 | 40,000 | - | - | Employee Stock Option (right to buy) | |
| Kelly Blackburn | VP, Clinical Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 18,250 | 18,250 | - | - | Employee Stock Option (right to buy) | |
| Andrew Cubitt | VP, Product Protection | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 8,500 | 8,500 | - | - | Employee Stock Option (right to buy) | |
| Holly D. Chrzanowski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 8,500 | 8,500 | - | - | Employee Stock Option (right to buy) | |
| Stan Blackburn | Acting Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 4,250 | 4,250 | - | - | Stock Option (right to buy) | |
| Nancy Krueger | VP, Legal Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 20,000 | 20,000 | - | - | Employee Stock Option (right to buy) | |
| John T. Blake | Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Jan 2016 | 20,000 | 20,000 | - | - | Employee Stock Option (right to buy) | |
| John D. Mendlein | Director, CEO and Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 148,732 | 148,732 | - | - | Employee Stock Option (right to buy) | |
| Melissa A. Ashlock | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 29,659 | 29,659 | - | - | Employee Stock Option (right to buy) | |
| John C. McKew | VP, Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 25,913 | 25,913 | - | - | Employee Stock Option (right to buy) | |
| Kelly Blackburn | VP, Clinical Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 26,470 | 26,470 | - | - | Employee Stock Option (right to buy) | |
| Andrew Cubitt | VP, Product Protection | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 16,874 | 16,874 | - | - | Employee Stock Option (right to buy) | |
| Holly D. Chrzanowski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 14,829 | 14,829 | - | - | Employee Stock Option (right to buy) | |
| Marcy Graham | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 12,023 | 12,023 | - | - | Employee Stock Option (right to buy) | |
| Stan Blackburn | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 5,754 | 5,754 | - | - | Employee Stock Option (right to buy) | |
| Nancy Krueger | VP, Legal Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 10,831 | 10,831 | - | - | Employee Stock Option (right to buy) | |
| John T. Blake | Vice President, Finance | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 5,038 | 5,038 | - | - | Employee Stock Option (right to buy) | |
| Sanuj K. Ravindran | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 10,750 | 10,750 | - | - | Employee Stock Option (right to buy) | |
| Sanuj K. Ravindran | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2016 | 153,000 | 153,000 | - | - | Employee Stock Option (right to buy) | |
| John D. Mendlein | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 71,000 | 71,000 | - | - | Employee Stock Option (right to buy) | |
| John D. Mendlein | Director, See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 65,070 | 65,070 | - | - | Employee Stock Option (right to buy) | |
| Melissa A. Ashlock | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 12,976 | 12,976 | - | - | Employee Stock Option (right to buy) | |
| Melissa A. Ashlock | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 30,000 | 30,000 | - | - | Employee Stock Option (right to buy) | |
| John C. McKew | VP, Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 23,000 | 23,000 | - | - | Employee Stock Option (right to buy) | |
| John C. McKew | VP, Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 11,337 | 11,337 | - | - | Employee Stock Option (right to buy) | |
| Fred Ramsdell | VP, Immunology | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 12,000 | 12,000 | - | - | Employee Stock Option (right to buy) | |
| Fred Ramsdell | VP, Immunology | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 5,393 | 5,393 | - | - | Employee Stock Option (right to buy) | |
| Kelly Blackburn | VP, Clinical Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 11,581 | 11,581 | - | - | Employee Stock Option (right to buy) | |
| Kelly Blackburn | VP, Clinical Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 45,500 | 45,500 | - | - | Employee Stock Option (right to buy) | |
| Andrew Cubitt | VP, Product Protection | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 7,382 | 7,382 | - | - | Employee Stock Option (right to buy) | |
| Andrew Cubitt | VP, Product Protection | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 23,000 | 23,000 | - | - | Employee Stock Option (right to buy) | |
| Holly D. Chrzanowski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 6,488 | 6,488 | - | - | Employee Stock Option (right to buy) | |
| Holly D. Chrzanowski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 24,000 | 24,000 | - | - | Employee Stock Option (right to buy) | |
| Marcy Graham | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 28,000 | 28,000 | - | - | Employee Stock Option (right to buy) | |
| Marcy Graham | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 5,260 | 5,260 | - | - | Employee Stock Option (right to buy) | |
| Stan Blackburn | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 9,500 | 9,500 | - | - | Employee Stock Option (right to buy) | |
| Stan Blackburn | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2015 | 2,518 | 2,518 | - | - | Employee Stock Option (right to buy) | |
| John K. Clarke | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jul 2015 | 6,286 | 6,286 | - | - | Stock Option (right to buy) | |
| Paul R. Schimmel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jul 2015 | 6,286 | 6,286 | - | - | Stock Option (right to buy) | |
| Kathryn E. Falberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jul 2015 | 6,286 | 6,286 | - | - | Stock Option (right to buy) | |
| James C. Blair | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jul 2015 | 6,286 | 6,286 | - | - | Stock Option (right to buy) | |
| Srinivas Akkaraju | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jul 2015 | 6,286 | 6,286 | - | - | Stock Option (right to buy) | |
| Mark A. Goldberg | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jul 2015 | 6,286 | 6,286 | - | - | Stock Option (right to buy) | |
| Amir Nashat | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jul 2015 | 6,286 | 6,286 | - | - | Stock Option (right to buy) | |
| Michael F. Powell | Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 12 May 2015 | 320,000 | 1,866,126 | - | - | Common Stock | |
| Jesse I. Treu | Ten Percent Owner | 12 May 2015 | 6,581 | 0 | - | - | Series E Preferred Stock | ||
| Brandon H. Hull | Ten Percent Owner | 12 May 2015 | 2,127,660 | 0 | - | - | Series C Redeemable Convertible Preferred Stock | ||
| Michael F. Powell | Ten Percent Owner | 12 May 2015 | 1,546,126 | 1,546,126 | - | - | Common Stock | ||
| Jesse I. Treu | Ten Percent Owner | 12 May 2015 | 11,182 | 0 | - | - | Series D Preferred Stock | ||
| Farah Champsi | Ten Percent Owner | 12 May 2015 | 3,600,000 | 0 | - | - | Series B Redeemable Convertible Preferred Stock | ||
| Jesse I. Treu | Ten Percent Owner | 12 May 2015 | 12,143,933 | 0 | - | - | Series C Preferred Stock | ||
| Brandon H. Hull | Ten Percent Owner | 12 May 2015 | 1,758,158 | 1,758,158 | - | - | Common Stock | ||
| Jesse I. Treu | Ten Percent Owner | 12 May 2015 | 90,110 | 0 | - | - | Series C Preferred Stock | ||
| Michael F. Powell | Ten Percent Owner | 12 May 2015 | 14,968,722 | 0 | - | - | Series E Redeemable Convertible Preferred Stock | ||
| Farah Champsi | Ten Percent Owner | 12 May 2015 | 92,306 | 1,778,064 | - | - | Common Stock | ||
| Farah Champsi | Ten Percent Owner | 12 May 2015 | 1,126,866 | 0 | - | - | Series D Redeemable Convertible Preferred Stock | ||
| Jesse I. Treu | Ten Percent Owner | 12 May 2015 | 13,414 | 13,414 | - | - | Common Stock | ||
| Farah Champsi | Ten Percent Owner | 12 May 2015 | 1,685,758 | 1,685,758 | - | - | Common Stock | ||
| Brandon H. Hull | Ten Percent Owner | 12 May 2015 | 4,320,173 | 0 | - | - | Series B-2 Redeemable Convertible Preferred Stock | ||
| Brandon H. Hull | Ten Percent Owner | 12 May 2015 | 1,536,787 | 0 | - | - | Series D Redeemable Convertible Preferred Stock | ||
| Brandon H. Hull | Ten Percent Owner | 12 May 2015 | 3,600,000 | 0 | - | - | Series B Redeemable Convertible Preferred Stock | ||
| Brandon H. Hull | Ten Percent Owner | 12 May 2015 | 2,400,000 | 0 | - | - | Series A Redeemable Convertible Preferred Stock | ||
| Farah Champsi | Ten Percent Owner | 12 May 2015 | 893,655 | 0 | - | - | Series E Redeemable Convertible Preferred Stock | ||
| Jesse I. Treu | Ten Percent Owner | 12 May 2015 | 1,807,820 | 1,807,820 | - | - | Common Stock | ||
| Farah Champsi | Ten Percent Owner | 12 May 2015 | 4,320,173 | 0 | - | - | Series B-2 Redeemable Convertible Preferred Stock | ||
| Jesse I. Treu | Ten Percent Owner | 12 May 2015 | 1,506,901 | 0 | - | - | Series D Preferred Stock | ||
| Farah Champsi | Ten Percent Owner | 12 May 2015 | 4,361,703 | 0 | - | - | Series C Redeemable Convertible Preferred Stock | ||
| Jesse I. Treu | Ten Percent Owner | 12 May 2015 | 887,073 | 0 | - | - | Series E Preferred Stock | ||
| John K. Clarke | Other | 12 May 2015 | 3,600,000 | 0 | - | - | Series B Redeemable Convertible Preferred Stock | ||
| John K. Clarke | Other | 12 May 2015 | 2,400,000 | 0 | - | - | Series A Redeemable Convertible Preferred Stock | ||
| John K. Clarke | Other | 12 May 2015 | 2,127,660 | 0 | - | - | Series C Redeemable Convertible Preferred Stock | ||
| John K. Clarke | Other | 12 May 2015 | 1,536,787 | 0 | - | - | Series D Redeemable Convertible Preferred Stock | ||
| John K. Clarke | Other | 12 May 2015 | 92,306 | 104,878 | - | - | Common Stock | ||
| John K. Clarke | Other | 12 May 2015 | 1,758,158 | 1,758,158 | - | - | Common Stock | ||
| John K. Clarke | Other | 12 May 2015 | 4,320,173 | 0 | - | - | Series B-2 Redeemable Convertible Preferred Stock | ||
| John K. Clarke | Other | 12 May 2015 | 893,655 | 0 | - | - | Series E Redeemable Convertible Preferred Stock | ||
| Paul R. Schimmel | None | 12 May 2015 | 470,020 | 600,015 | - | - | Common Stock | ||
| Paul R. Schimmel | None | 12 May 2015 | 446,827 | 0 | - | - | Series E Redeemable Convertible Preferred Stock | ||
| Paul R. Schimmel | None | 12 May 2015 | 248,024 | 0 | - | - | Series D Redeemable Convertible Preferred Stock | ||
| Paul R. Schimmel | None | 12 May 2015 | 31,181 | 31,181 | - | - | Common Stock | ||
| Paul R. Schimmel | None | 12 May 2015 | 558,508 | 0 | - | - | Series C Redeemable Convertible Preferred Stock | ||
| Paul R. Schimmel | None | 12 May 2015 | 1,200,000 | 0 | - | - | Series B Redeemable Convertible Preferred Stock | ||
| Paul R. Schimmel | None | 12 May 2015 | 15,031 | 0 | - | - | Series D Redeemable Convertible Preferred Stock | ||
| Paul R. Schimmel | None | 12 May 2015 | 1,440,058 | 0 | - | - | Series B-2 Redeemable Convertible Preferred Stock | ||
| Paul R. Schimmel | None | 12 May 2015 | 525,000 | 0 | - | - | Series A Redeemable Convertible Preferred Stock | ||
| Paul R. Schimmel | None | 12 May 2015 | 46,152 | 646,167 | - | - | Common Stock | ||
| Srinivas Akkaraju | Other | 12 May 2015 | 1,546,126 | 1,546,126 | - | - | Common Stock | ||
| Srinivas Akkaraju | Other | 12 May 2015 | 14,968,722 | 0 | - | - | Series E Redeemable Convertible Preferred Stock | ||
| Srinivas Akkaraju | Other | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 12 May 2015 | 320,000 | 1,866,126 | - | - | Common Stock | |
| Flynn E James | Other | 12 May 2015 | 230,764 | 230,764 | - | - | Common Stock | ||
| Flynn E James | Other | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 12 May 2015 | 25,000 | 255,764 | - | - | Common Stock | |
| Flynn E James | Other | 12 May 2015 | 2,234,137 | 0 | - | - | Series E Preferred Stock | ||
| Flynn E James | Other | 12 May 2015 | 230,764 | 230,764 | - | - | Common Stock | ||
| Flynn E James | Other | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 12 May 2015 | 25,000 | 255,764 | - | - | Common Stock | |
| Flynn E James | Other | 12 May 2015 | 2,234,137 | 0 | - | - | Series E Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 67,704 | 0 | - | - | Series B Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 16,806 | 0 | - | - | Series E Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 4,208,756 | 0 | - | - | Series C Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 89,069 | 1,763,894 | - | - | Common Stock | ||
| Amir Nashat | Other | 12 May 2015 | 41,686 | 0 | - | - | Series B-2 Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 16,748 | 16,748 | - | - | Common Stock | ||
| Amir Nashat | Other | 12 May 2015 | 82,029 | 0 | - | - | Series C Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 1,736 | 34,378 | - | - | Common Stock | ||
| Amir Nashat | Other | 12 May 2015 | 81,248 | 0 | - | - | Series B-2 Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 32,642 | 32,642 | - | - | Common Stock | ||
| Amir Nashat | Other | 12 May 2015 | 1,470,577 | 0 | - | - | Series D Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 34,737 | 0 | - | - | Series B Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 8,623 | 0 | - | - | Series E Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 28,556 | 0 | - | - | Series B-2 Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 11,472 | 11,472 | - | - | Common Stock | ||
| Amir Nashat | Other | 12 May 2015 | 3,473,763 | 0 | - | - | Series B Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 862,318 | 0 | - | - | Series E Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 4,168,683 | 0 | - | - | Series B-2 Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 1,674,825 | 1,674,825 | - | - | Common Stock | ||
| Amir Nashat | Other | 12 May 2015 | 23,796 | 0 | - | - | Series B Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 5,906 | 0 | - | - | Series E Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 14,706 | 0 | - | - | Series D Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 28,661 | 0 | - | - | Series D Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 10,074 | 0 | - | - | Series D Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 42,087 | 0 | - | - | Series C Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 890 | 17,638 | - | - | Common Stock | ||
| Amir Nashat | Other | 12 May 2015 | 28,831 | 0 | - | - | Series C Redeemable Convertible Preferred Stock | ||
| Amir Nashat | Other | 12 May 2015 | 610 | 12,082 | - | - | Common Stock | ||
| John D. Mendlein | Director, CEO and Executive Chairman | 12 May 2015 | 21,122 | 0 | - | - | Series D Redeemable Convertible Preferred Stock | ||
| John D. Mendlein | Director, CEO and Executive Chairman | 12 May 2015 | 170,218 | 0 | - | - | Series C Redeemable Convertible Preferred Stock | ||
| John D. Mendlein | Director, CEO and Executive Chairman | 12 May 2015 | 24,055 | 245,971 | - | - | Common Stock | ||
| John D. Mendlein | Director, CEO & Executive Chariman | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2015 | 163,437 | 163,437 | - | - | Stock Option (right to buy) | |
| Melissa A. Ashlock | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2015 | 25,144 | 25,144 | - | - | Stock Option (right to buy) | |
| Frederic Chereau | President & COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2015 | 22,001 | 22,001 | - | - | Stock Option (right to buy) | |
| David M. Weiner | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2015 | 44,002 | 44,002 | - | - | Stock Option (right to buy) | |
| John C. McKew | Vice President, Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2015 | 25,144 | 25,144 | - | - | Stock Option (right to buy) | |
| Fred Ramsdell | Vice President, Immunology | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2015 | 17,600 | 17,600 | - | - | Stock Option (right to buy) | |
| Kelly Blackburn | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2015 | 34,573 | 34,573 | - | - | Stock Option (right to buy) | |
| Andrew Cubitt | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2015 | 5,657 | 5,657 | - | - | Stock Option (right to buy) | |
| Holly D. Chrzanowski | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2015 | 11,943 | 11,943 | - | - | Stock Option (right to buy) | |
| Marcy Graham | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2015 | 10,686 | 10,686 | - | - | Stock Option (right to buy) | |
| Stan Blackburn | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2015 | 4,085 | 4,085 | - | - | Stock Option (right to buy) |