Insider Trading disclosures for Arvinas Inc

The latest disclosure was made by John G. Houston in Arvinas Inc where a trade of 5,154 Common Stock done at an average price of $16.6 was reported to US exchanges on Feb. 24, 2025.

Insider trading is the trading of a company’s securities by individuals with access to confidential or material non-public information about the company. A company is required to report trading by corporate officers, directors, or other company members with significant access to privileged information to the Securities and Exchange Commission (SEC).

Client Name	Client Category	Action	Reported to Exchange	Quantity	Post Transaction Holding	Traded %	Avg. Price	Value	Security Type
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 16.55 per share.	24 Feb 2025	5,154	1,157,480 (2%)	0%	16.6	85,299	Common Stock
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 16.75 per share.	24 Feb 2025	26,184	1,162,634 (2%)	0%	16.8	438,582	Common Stock
Ian Taylor	President, R&D	Sale of securities on an exchange or to another person at price $ 16.75 per share.	24 Feb 2025	7,356	160,785 (0%)	0%	16.8	123,213	Common Stock
Ian Taylor	President, R&D	Sale of securities on an exchange or to another person at price $ 16.55 per share.	24 Feb 2025	1,664	159,121 (0%)	0%	16.5	27,539	Common Stock
Angela Cacace	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 16.55 per share.	24 Feb 2025	1,146	97,231 (0%)	0%	16.5	18,966	Common Stock
Angela Cacace	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 16.75 per share.	24 Feb 2025	3,061	98,377 (0%)	0%	16.8	51,272	Common Stock
David Loomis	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 16.75 per share.	24 Feb 2025	1,214	18,863 (0%)	0%	16.8	20,335	Common Stock
Andrew Saik	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	49,092	110,501 (0%)	0%		0	Common Stock
Andrew Saik	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	74,960	74,960	-		-	Stock Option (right to buy)
John G. Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	152,000	1,188,681 (3%)	0%		0	Common Stock
John G. Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	232,000	232,000	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	20,619	168,141 (0%)	0%		0	Common Stock
Ian Taylor	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	31,483	31,483	-		-	Stock Option (right to buy)
Angela Cacace	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	74,960	74,960	-		-	Stock Option (right to buy)
Angela Cacace	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	49,092	100,944 (0%)	0%		0	Common Stock
David Loomis	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	16,176	16,176	-		-	Stock Option (right to buy)
David Loomis	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	10,584	18,624 (0%)	0%		0	Common Stock
Noah Berkowitz	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	55,229	118,681 (0%)	0%		0	Common Stock
Noah Berkowitz	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	13 Feb 2025	84,330	84,330	-		-	Stock Option (right to buy)
Andrew Saik	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 Jun 2024	61,409	61,409 (0%)	0%		0	Common Stock
Andrew Saik	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 Jun 2024	94,418	94,418	-		-	Stock Option (right to buy)
Angela Cacace	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Jun 2024	15,995	51,852 (0%)	0%		0	Common Stock
Angela Cacace	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	17 Jun 2024	24,632	24,632	-		-	Stock Option (right to buy)
John Douglas Young	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	5,899	10,020 (0%)	0%		0	Common Stock
John Douglas Young	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	9,070	9,070	-		-	Stock Option (right to buy)
Leslie V. Norwalk	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	9,070	9,070	-		-	Stock Option (right to buy)
Leslie V. Norwalk	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	5,899	10,020 (0%)	0%		0	Common Stock
Everett V. Cunningham	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	9,070	9,070	-		-	Stock Option (right to buy)
Everett V. Cunningham	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	5,899	10,020 (0%)	0%		0	Common Stock
Briggs W. Morrison	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	5,899	29,996 (0%)	0%		0	Common Stock
Briggs W. Morrison	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	9,070	9,070	-		-	Stock Option (right to buy)
Linda C. Bain	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	9,070	9,070	-		-	Stock Option (right to buy)
Linda C. Bain	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	5,899	10,020 (0%)	0%		0	Common Stock
Laurie Smaldone Alsup	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	9,070	9,070	-		-	Stock Option (right to buy)
Laurie Smaldone Alsup	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	5,899	10,020 (0%)	0%		0	Common Stock
Sunil Agarwal	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	5,899	14,141 (0%)	0%		0	Common Stock
Sunil Agarwal	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	9,070	9,070	-		-	Stock Option (right to buy)
Edward Kennedy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	9,070	9,070	-		-	Stock Option (right to buy)
Edward Kennedy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 May 2024	5,899	23,405 (0%)	0%		0	Common Stock
Randy Teel	Int. Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2024	13,300	59,341 (0%)	0%		0	Common Stock
Randy Teel	Int. Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	21 May 2024	19,675	19,675	-		-	Stock Option (right to buy)
Berkowitz Noah	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	18 Mar 2024	63,452	63,452 (0%)	0%		0	Common Stock
Berkowitz Noah	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	18 Mar 2024	93,879	93,879	-		-	Stock Option (right to buy)
John Houston G.	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 Feb 2024	184,200	184,200	-		-	Stock Option (right to buy)
Taylor Ian	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 Feb 2024	39,250	149,223 (0%)	0%		0	Common Stock
David Loomis	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 Feb 2024	5,750	8,500 (0%)	0%		0	Common Stock
G. Houston John	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 Feb 2024	124,450	1,041,877 (2%)	0%		0	Common Stock
Ian Taylor	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 Feb 2024	58,100	58,100	-		-	Stock Option (right to buy)
Peck Ronald	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 Feb 2024	39,250	69,215 (0%)	0%		0	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 47.05 per share.	23 Feb 2024	1,702	181,916 (0%)	0%	47.0	80,079	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 47.05 per share.	23 Feb 2024	1,701	147,522 (0%)	0%	47.0	80,032	Common Stock
Peck Ronald	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 Feb 2024	58,100	58,100	-		-	Stock Option (right to buy)
David Loomis	Chief Accounting Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 Feb 2024	8,750	8,750	-		-	Stock Option (right to buy)
G. John Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 47.05 per share.	23 Feb 2024	5,196	1,036,681 (2%)	0%	47.1	244,472	Common Stock
Peck Ronald	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 47.05 per share.	23 Feb 2024	1,699	67,516 (0%)	0%	47.1	79,938	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	04 Jan 2024	8,252	109,973 (0%)	0%	16	132,032	Common Stock
David Loomis	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 17.05 per share.	08 Nov 2023	229	8,271 (0%)	0%	17.0	3,904	Common Stock
David Loomis	Chief Accounting Officer	Sale of securities on an exchange or to another person at price $ 27.69 per share.	08 Nov 2023	231	8,040 (0%)	0%	27.7	6,396	Common Stock
Ronald Peck	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Aug 2023	4,010	0	-		-	Restricted Stock Units
Ronald Peck	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 24.39 per share.	11 Aug 2023	1,324	29,965 (0%)	0%	24.4	32,289	Common Stock
Ronald Peck	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Aug 2023	4,010	31,289 (0%)	0%		-	Common Stock
Wendy L. Dixon	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	4,121	9,121 (0%)	0%		0	Common Stock
Wendy L. Dixon	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	12,787	12,787	-		-	Stock Option (right to buy)
John Douglas Young	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	12,787	12,787	-		-	Stock Option (right to buy)
John Douglas Young	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	4,121	4,121 (0%)	0%		0	Common Stock
Leslie V. Norwalk	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	4,121	4,121 (0%)	0%		0	Common Stock
Leslie V. Norwalk	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	12,787	12,787	-		-	Stock Option (right to buy)
Everett V. Cunningham	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	12,787	12,787	-		-	Stock Option (right to buy)
Everett V. Cunningham	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	4,121	4,121 (0%)	0%		0	Common Stock
Briggs W. Morrison	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	12,787	12,787	-		-	Stock Option (right to buy)
Briggs W. Morrison	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	4,121	24,097 (0%)	0%		0	Common Stock
Linda C. Bain	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	4,121	4,121 (0%)	0%		0	Common Stock
Linda C. Bain	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	12,787	12,787	-		-	Stock Option (right to buy)
Laurie Smaldone Alsup	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	12,787	12,787	-		-	Stock Option (right to buy)
Laurie Smaldone Alsup	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	4,121	4,121 (0%)	0%		0	Common Stock
Sunil Agarwal	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	8,242	8,242 (0%)	0%		0	Common Stock
Sunil Agarwal	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	24,948	24,948	-		-	Stock Option (right to buy)
Edward Kennedy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	4,121	17,506 (0%)	0%		0	Common Stock
Edward Kennedy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Jun 2023	12,787	12,787	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 29.53 per share.	01 Mar 2023	1,745	183,618 (0%)	0%	29.5	51,530	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Mar 2023	4,791	0	-		-	Restricted Stock Units
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Mar 2023	4,791	185,363 (0%)	0%		-	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Mar 2023	17,510	923,305 (2%)	0%		-	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Mar 2023	17,510	0	-		-	Restricted Stock Units
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 29.53 per share.	01 Mar 2023	5,878	917,427 (2%)	0%	29.5	173,577	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Mar 2023	2,685	102,772 (0%)	0%		-	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 29.53 per share.	01 Mar 2023	1,051	101,721 (0%)	0%	29.5	31,036	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Mar 2023	2,685	0	-		-	Restricted Stock Units
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 Feb 2023	19,125	180,572 (0%)	0%		0	Common Stock
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 Feb 2023	57,450	57,450	-		-	Stock Option (right to buy)
John G. Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 Feb 2023	186,250	186,250	-		-	Stock Option (right to buy)
John G. Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 Feb 2023	61,975	905,795 (2%)	0%		0	Common Stock
Ian Taylor	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 Feb 2023	57,450	57,450	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 Feb 2023	19,125	100,087 (0%)	0%		0	Common Stock
Ronald Peck	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 Feb 2023	57,450	57,450	-		-	Stock Option (right to buy)
Ronald Peck	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	22 Feb 2023	19,125	27,279 (0%)	0%		0	Common Stock
Everett V. Cunningham	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	15 Dec 2022	30,095	30,095	-		-	Common Stock
John Douglas Young	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	18 Aug 2022	24,572	24,572	-		-	Stock Option (right to buy)
Ronald Peck	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Aug 2022	4,010	9,412 (0%)	0%		-	Common Stock
Ronald Peck	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Aug 2022	4,010	4,010	-		-	Restricted Stock Units
Ronald Peck	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 54.84 per share.	12 Aug 2022	1,258	8,154 (0%)	0%	54.8	68,994	Common Stock
Timothy M. Shannon	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 Jun 2022	10,192	10,192	-		-	Stock Option (right to buy)
Wendy L. Dixon	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 Jun 2022	10,192	10,192	-		-	Stock Option (right to buy)
Leslie V. Norwalk	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 Jun 2022	10,192	10,192	-		-	Stock Option (right to buy)
Liam Ratcliffe	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 Jun 2022	10,192	10,192	-		-	Stock Option (right to buy)
Briggs W. Morrison	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 Jun 2022	10,192	10,192	-		-	Stock Option (right to buy)
Linda C. Bain	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 Jun 2022	10,192	10,192	-		-	Stock Option (right to buy)
Laurie Smaldone Alsup	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 Jun 2022	10,192	10,192	-		-	Stock Option (right to buy)
Edward Kennedy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 Jun 2022	10,192	10,192	-		-	Stock Option (right to buy)
Bradley Margus	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	16 Jun 2022	10,192	10,192	-		-	Stock Option (right to buy)
Briggs W. Morrison	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	14 Apr 2022	16,188	40,936 (0%)	0%	16	259,008	Common Stock
Briggs W. Morrison	Director	Sale of securities on an exchange or to another person at price $ 65.24 per share.	14 Apr 2022	3,102	37,834 (0%)	0%	65.2	202,372	Common Stock
Briggs W. Morrison	Director	Sale of securities on an exchange or to another person at price $ 66.07 per share.	14 Apr 2022	7,104	30,730 (0%)	0%	66.1	469,356	Common Stock
Briggs W. Morrison	Director	Sale of securities on an exchange or to another person at price $ 67.03 per share.	14 Apr 2022	10,754	19,976 (0%)	0%	67.0	720,888	Common Stock
Briggs W. Morrison	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	14 Apr 2022	16,188	494	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	11 Mar 2022	15,000	176,447 (0%)	0%	16	240,000	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	11 Mar 2022	15,000	16,710	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 70.00 per share.	11 Mar 2022	15,000	161,447 (0%)	0%	70	1,050,000	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	01 Mar 2022	3,500	82,145 (0%)	0%	16	56,000	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Mar 2022	1,979	6,964	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Mar 2022	925	13,872	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Mar 2022	596	0	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 75.80 per share.	15 Feb 2022	300	78,745 (0%)	0%	75.8	22,740	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Feb 2022	20,000	37,633	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 76.58 per share.	15 Feb 2022	100	78,645 (0%)	0%	76.6	7,658	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 74.64 per share.	15 Feb 2022	3,841	79,045 (0%)	0%	74.6	286,692	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 73.68 per share.	15 Feb 2022	4,126	82,886 (0%)	0%	73.7	304,004	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 72.55 per share.	15 Feb 2022	5,766	87,012 (0%)	0%	72.5	418,323	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 71.74 per share.	15 Feb 2022	5,867	92,778 (0%)	0%	71.7	420,899	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.36 per share.	15 Feb 2022	20,000	98,645 (0%)	0%	19.4	387,200	Common Stock
Briggs W. Morrison	Director	Sale of securities on an exchange or to another person at price $ 67.69 per share.	14 Jan 2022	2,108	24,748 (0%)	0%	67.7	142,696	Common Stock
Briggs W. Morrison	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	14 Jan 2022	16,188	45,708 (0%)	0%	16	259,008	Common Stock
Briggs W. Morrison	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	14 Jan 2022	16,188	16,682	-		-	Stock Option (right to buy)
Briggs W. Morrison	Director	Sale of securities on an exchange or to another person at price $ 64.33 per share.	14 Jan 2022	9,919	35,789 (0%)	0%	64.3	638,109	Common Stock
Briggs W. Morrison	Director	Sale of securities on an exchange or to another person at price $ 65.24 per share.	14 Jan 2022	3,833	31,956 (0%)	0%	65.2	250,071	Common Stock
Briggs W. Morrison	Director	Sale of securities on an exchange or to another person at price $ 67.28 per share.	14 Jan 2022	5,100	26,856 (0%)	0%	67.3	343,144	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 66.01 per share.	14 Dec 2021	119,456	421,935 (1%)	0%	66.0	7,885,099	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 68.97 per share.	14 Dec 2021	37,206	185,686 (0%)	0%	69.0	2,566,031	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 69.66 per share.	14 Dec 2021	48,499	222,892 (0%)	0%	69.7	3,378,387	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 65.74 per share.	14 Dec 2021	5,695	271,391 (0%)	0%	65.7	374,366	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 66.50 per share.	14 Dec 2021	67,549	277,086 (0%)	0%	66.5	4,492,326	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 67.46 per share.	14 Dec 2021	40,292	344,635 (0%)	0%	67.5	2,718,272	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 64.20 per share.	14 Dec 2021	700	384,927 (0%)	0%	64.2	44,941	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 65.38 per share.	14 Dec 2021	36,308	385,627 (0%)	0%	65.4	2,373,959	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.36 per share.	15 Nov 2021	7,794	98,645 (0%)	0%	19.4	150,892	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Nov 2021	7,794	57,633	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	15 Nov 2021	12,206	8,943	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 84.95 per share.	15 Nov 2021	6,484	78,645 (0%)	0%	85.0	550,845	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 84.14 per share.	15 Nov 2021	6,660	85,129 (0%)	0%	84.1	560,392	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 83.07 per share.	15 Nov 2021	6,856	91,789 (0%)	0%	83.1	569,509	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	15 Nov 2021	12,206	90,851 (0%)	0%	16	195,296	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 89.16 per share.	10 Nov 2021	1,498	672,351 (1%)	0%	89.2	133,560	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 83.90 per share.	10 Nov 2021	3,532	541,391 (1%)	0%	83.9	296,347	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 85.07 per share.	10 Nov 2021	17,752	544,923 (1%)	0%	85.1	1,510,122	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 84.02 per share.	10 Nov 2021	12,760	562,675 (1%)	0%	84.0	1,072,100	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 84.31 per share.	10 Nov 2021	9,660	575,435 (1%)	0%	84.3	814,474	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 85.96 per share.	10 Nov 2021	17,449	585,095 (1%)	0%	86.0	1,499,886	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 85.92 per share.	10 Nov 2021	36,210	602,544 (1%)	0%	85.9	3,111,333	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 86.38 per share.	10 Nov 2021	18,007	638,754 (1%)	0%	86.4	1,555,468	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 87.71 per share.	10 Nov 2021	5,582	656,761 (1%)	0%	87.7	489,591	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 86.59 per share.	10 Nov 2021	199	662,343 (1%)	0%	86.6	17,231	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 87.11 per share.	10 Nov 2021	3,956	662,542 (1%)	0%	87.1	344,624	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 88.12 per share.	10 Nov 2021	5,853	666,498 (1%)	0%	88.1	515,760	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 90.18 per share.	10 Nov 2021	1,852	673,849 (1%)	0%	90.2	167,013	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 90.75 per share.	05 Nov 2021	4,940	6,500 (0%)	0%	90.8	448,305	Common Stock
Liam Ratcliffe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Nov 2021	12,000	0	-		-	Stock Option (right to buy)
Liam Ratcliffe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Nov 2021	6,423	0	-		-	Stock Option (right to buy)
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 91.33 per share.	05 Nov 2021	580	675,701 (1%)	0%	91.3	52,969	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 91.85 per share.	05 Nov 2021	27,297	676,281 (1%)	0%	91.8	2,507,093	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 92.73 per share.	05 Nov 2021	5,131	703,578 (1%)	0%	92.7	475,800	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 92.48 per share.	05 Nov 2021	3,688	708,709 (1%)	0%	92.5	341,051	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 93.03 per share.	05 Nov 2021	11,130	712,397 (1%)	0%	93.0	1,035,446	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 94.20 per share.	05 Nov 2021	11,668	723,527 (1%)	0%	94.2	1,099,129	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 94.93 per share.	05 Nov 2021	54,568	735,195 (1%)	0%	94.9	5,180,255	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 89.86 per share.	05 Nov 2021	2,747	789,763 (2%)	0%	89.9	246,854	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 91.09 per share.	05 Nov 2021	8,676	792,510 (2%)	0%	91.1	790,300	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 91.81 per share.	05 Nov 2021	15,327	801,186 (2%)	0%	91.8	1,407,244	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 93.03 per share.	05 Nov 2021	1,825	816,513 (2%)	0%	93.0	169,785	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 94.08 per share.	05 Nov 2021	4,519	818,338 (2%)	0%	94.1	425,136	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 89.65 per share.	05 Nov 2021	484	0 (0%)	0%	89.7	43,391	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 90.29 per share.	05 Nov 2021	795	484 (0%)	0%	90.3	71,781	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 91.59 per share.	05 Nov 2021	5,221	1,279 (0%)	0%	91.6	478,191	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 91.50 per share.	05 Nov 2021	7,060	11,440 (0%)	0%	91.5	645,990	Common Stock
Liam Ratcliffe	Director	Sale of securities on an exchange or to another person at price $ 91.50 per share.	05 Nov 2021	6,423	18,500 (0%)	0%	91.5	587,705	Common Stock
Liam Ratcliffe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 33.57 per share.	05 Nov 2021	12,000	24,923 (0%)	0%	33.6	402,840	Common Stock
Liam Ratcliffe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.06 per share.	05 Nov 2021	6,423	12,923 (0%)	0%	22.1	141,691	Common Stock
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 88.86 per share.	01 Nov 2021	15,569	832,333 (2%)	0%	88.9	1,383,499	Common Stock
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 87.98 per share.	01 Nov 2021	15,918	847,902 (2%)	0%	88.0	1,400,478	Common Stock
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 87.13 per share.	01 Nov 2021	8,513	863,820 (2%)	0%	87.1	741,747	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	01 Nov 2021	40,000	872,333 (2%)	0%	16	640,000	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	01 Nov 2021	40,000	0	-		-	Stock Option (right to buy)
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 87.98 per share.	03 Sep 2021	14,751	1,674,788 (4%)	0%	88.0	1,297,740	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 85.47 per share.	03 Sep 2021	30,068	1,691,858 (4%)	0%	85.5	2,569,801	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 86.39 per share.	03 Sep 2021	2,319	1,689,539 (4%)	0%	86.4	200,345	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 90.75 per share.	03 Sep 2021	2,030	1,653,128 (4%)	0%	90.7	184,218	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 90.08 per share.	03 Sep 2021	14,163	1,655,158 (4%)	0%	90.1	1,275,831	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 88.90 per share.	03 Sep 2021	5,467	1,669,321 (4%)	0%	88.9	486,006	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Sep 2021	2,228	40,000	-		-	Stock Option (right to buy)
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	02 Sep 2021	2,228	829,871 (2%)	0%	16	35,648	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Sep 2021	2,462	40,272	-		-	Stock Option (right to buy)
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	02 Sep 2021	2,462	832,333 (2%)	0%	16	39,392	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 88.59 per share.	31 Aug 2021	11,863	1,773,691 (4%)	0%	88.6	1,050,884	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 87.86 per share.	31 Aug 2021	19,275	1,785,554 (4%)	0%	87.9	1,693,586	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 86.79 per share.	31 Aug 2021	29,478	1,804,829 (4%)	0%	86.8	2,558,446	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 85.67 per share.	31 Aug 2021	18,821	1,834,307 (4%)	0%	85.7	1,612,305	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 86.21 per share.	31 Aug 2021	12,189	1,853,128 (4%)	0%	86.2	1,050,859	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 85.39 per share.	31 Aug 2021	47,166	1,865,317 (4%)	0%	85.4	4,027,292	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 86.34 per share.	31 Aug 2021	23,316	1,721,926 (4%)	0%	86.3	2,013,059	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 85.42 per share.	31 Aug 2021	28,449	1,745,242 (4%)	0%	85.4	2,430,057	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 88.22 per share.	26 Aug 2021	1,181	1,912,483 (4%)	0%	88.2	104,191	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 85.12 per share.	26 Aug 2021	11,712	2,016,347 (5%)	0%	85.1	996,970	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 85.38 per share.	26 Aug 2021	42,655	1,973,692 (5%)	0%	85.4	3,641,914	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 86.06 per share.	26 Aug 2021	2,371	1,971,321 (5%)	0%	86.1	204,037	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 85.19 per share.	26 Aug 2021	24,607	1,946,714 (4%)	0%	85.2	2,096,354	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 86.40 per share.	26 Aug 2021	25,469	1,921,245 (4%)	0%	86.4	2,200,514	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 87.51 per share.	26 Aug 2021	7,581	1,913,664 (4%)	0%	87.5	663,399	Common Stock
Bradley Margus	Director	Sale of securities on an exchange or to another person at price $ 85.03 per share.	25 Aug 2021	9,940	2,000 (0%)	0%	85.0	845,168	Common Stock
Bradley Margus	Director	Sale of securities on an exchange or to another person at price $ 85.00 per share.	25 Aug 2021	20,000	11,940 (0%)	0%	85	1,700,000	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 86.95 per share.	23 Aug 2021	4,568	2,046,961 (5%)	0%	87.0	397,201	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 85.03 per share.	23 Aug 2021	14,267	2,028,059 (5%)	0%	85.0	1,213,144	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 87.08 per share.	23 Aug 2021	4,635	2,042,326 (5%)	0%	87.1	403,617	Common Stock
Timothy M. Shannon	Director	Sale of securities on an exchange or to another person at price $ 88.01 per share.	23 Aug 2021	1,599	2,051,529 (5%)	0%	88.0	140,728	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 88.28 per share.	16 Aug 2021	301	78,645 (0%)	0%	88.3	26,572	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Aug 2021	6,196	21,149	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Aug 2021	13,804	14,797	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 86.84 per share.	16 Aug 2021	9,237	89,408 (0%)	0%	86.8	802,141	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	16 Aug 2021	20,000	98,645 (0%)	0%	16	320,000	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 87.67 per share.	16 Aug 2021	10,462	78,946 (0%)	0%	87.7	917,204	Common Stock
Ronald Peck	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 90.53 per share.	12 Aug 2021	1,363	5,402 (0%)	0%	90.5	123,399	Common Stock
Ronald Peck	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Aug 2021	4,011	8,020	-		-	Restricted Stock Units
Ronald Peck	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	12 Aug 2021	4,011	6,765 (0%)	0%		-	Common Stock
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 99.96 per share.	02 Aug 2021	3,441	830,389 (2%)	0%	100.0	343,962	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	02 Aug 2021	45,922	42,228	-		-	Stock Option (right to buy)
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 100.66 per share.	02 Aug 2021	2,746	827,643 (2%)	0%	100.7	276,412	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	02 Aug 2021	45,922	873,565 (2%)	0%	16	734,752	Common Stock
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 98.86 per share.	02 Aug 2021	7,600	833,830 (2%)	0%	98.9	751,336	Common Stock
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 97.66 per share.	02 Aug 2021	6,992	841,430 (2%)	0%	97.7	682,839	Common Stock
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 96.96 per share.	02 Aug 2021	25,143	848,422 (2%)	0%	97.0	2,437,865	Common Stock
Timothy M. Shannon	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	08 Jun 2021	7,511	7,511	-		-	Stock Option (right to buy)
Wendy L. Dixon	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	08 Jun 2021	7,511	7,511	-		-	Stock Option (right to buy)
Leslie V. Norwalk	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	08 Jun 2021	7,511	7,511	-		-	Stock Option (right to buy)
Liam Ratcliffe	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	08 Jun 2021	7,511	7,511	-		-	Stock Option (right to buy)
Briggs Morrison	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	08 Jun 2021	7,511	7,511	-		-	Stock Option (right to buy)
Linda C. Bain	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	08 Jun 2021	7,511	7,511	-		-	Stock Option (right to buy)
Laurie Smaldone Alsup	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	08 Jun 2021	7,511	7,511	-		-	Stock Option (right to buy)
Edward Kennedy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	08 Jun 2021	7,511	7,511	-		-	Stock Option (right to buy)
Bradley Margus	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	08 Jun 2021	7,511	7,511	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 66.01 per share.	05 Apr 2021	4,100	99,545 (0%)	0%	66.0	270,641	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Apr 2021	15,789	28,601	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	05 Apr 2021	9,211	0	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 67.56 per share.	05 Apr 2021	4,450	78,645 (0%)	0%	67.6	300,642	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 66.80 per share.	05 Apr 2021	16,450	83,095 (0%)	0%	66.8	1,098,860	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	05 Apr 2021	25,000	103,645 (0%)	0%	16	400,000	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	26 Feb 2021	4,792	160,470 (0%)	0%		-	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	26 Feb 2021	4,792	9,582	-		-	Restricted Stock Units
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Feb 2021	68,000	0	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 77.45 per share.	26 Feb 2021	2,221	158,249 (0%)	0%	77.4	172,015	Common Stock
John G. Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 28.50 per share.	26 Feb 2021	315	817,938 (2%)	0%	28.5	8,978	Common Stock
John G. Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Feb 2021	219,500	0	-		-	Stock Option (right to buy)
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 77.45 per share.	26 Feb 2021	8,115	827,643 (2%)	0%	77.4	628,503	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	26 Feb 2021	17,510	835,758 (2%)	0%		-	Common Stock
John G. Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 29.02 per share.	26 Feb 2021	310	818,248 (2%)	0%	29.0	8,996	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	26 Feb 2021	17,510	35,021	-		-	Restricted Stock Units
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	26 Feb 2021	2,685	5,371	-		-	Restricted Stock Units
Ian Taylor	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Feb 2021	68,000	0	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 77.45 per share.	26 Feb 2021	894	78,645 (0%)	0%	77.4	69,240	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	26 Feb 2021	2,685	79,539 (0%)	0%		-	Common Stock
Ronald Peck	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Feb 2021	68,000	0	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Feb 2021	704	596	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Feb 2021	3,315	27,345	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Feb 2021	2,437	9,211	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	19 Feb 2021	6,456	76,854 (0%)	0%	16	103,296	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	17 Feb 2021	569	155,678 (0%)	0%	16	9,104	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	17 Feb 2021	569	22,127	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	17 Feb 2021	325	1,192	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	17 Feb 2021	325	155,109 (0%)	0%	16	5,200	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 77.60 per share.	16 Feb 2021	8,158	188,585 (0%)	0%	77.6	633,044	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 79.32 per share.	16 Feb 2021	3,958	165,324 (0%)	0%	79.3	313,934	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Feb 2021	35,144	46,262	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Feb 2021	6,815	0	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 80.43 per share.	16 Feb 2021	30	154,784 (0%)	0%	80.4	2,413	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 79.42 per share.	16 Feb 2021	1,161	154,814 (0%)	0%	79.4	92,211	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 78.65 per share.	16 Feb 2021	6,160	155,975 (0%)	0%	78.6	484,462	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 77.62 per share.	16 Feb 2021	2,793	162,135 (0%)	0%	77.6	216,795	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 80.28 per share.	16 Feb 2021	396	164,928 (0%)	0%	80.3	31,791	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	16 Feb 2021	6,815	161,599 (0%)	0%	16	109,040	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	16 Feb 2021	35,144	196,743 (0%)	0%	16	562,304	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 78.61 per share.	16 Feb 2021	19,303	169,282 (0%)	0%	78.6	1,517,457	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	16 Feb 2021	1,560	817,760 (2%)	0%	16	24,960	Common Stock
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 77.62 per share.	16 Feb 2021	8,928	851,272 (2%)	0%	77.6	692,982	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	16 Feb 2021	44,000	860,000 (2%)	0%	16	704,000	Common Stock
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Feb 2021	1,560	87,320	-		-	Stock Option (right to buy)
John G. Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Feb 2021	44,000	88,880	-		-	Stock Option (right to buy)
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 80.25 per share.	16 Feb 2021	600	816,200 (2%)	0%	80.3	48,150	Common Stock
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 79.72 per share.	16 Feb 2021	13,223	816,800 (2%)	0%	79.7	1,054,091	Common Stock
John G. Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 78.66 per share.	16 Feb 2021	21,249	830,023 (2%)	0%	78.7	1,671,378	Common Stock
Ronald Peck	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.58 per share.	16 Feb 2021	20,000	22,754 (0%)	0%	26.6	531,600	Common Stock
Ronald Peck	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	16 Feb 2021	20,000	52,184	-		-	Stock Option (right to buy)
Ronald Peck	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 77.35 per share.	16 Feb 2021	20,000	2,754 (0%)	0%	77.3	1,546,992	Common Stock
Liam Ratcliffe	Director	Purchase of securities on an exchange or from another person at price $ 70.00 per share.	18 Dec 2020	142,857	822,857 (2%)	0%	70	9,999,990	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	09 Nov 2020	3,006	154,784 (0%)	0%	16	48,096	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Nov 2020	2,356	22,696	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	09 Nov 2020	650	1,517	-		-	Stock Option (right to buy)
Edward Kennedy	Director	Purchase of securities on an exchange or from another person at price $ 23.99 per share.	09 Nov 2020	8,333	42,718 (0%)	0%	24.0	199,909	Common Stock
Ronald Peck	Chief Medical Officer	Sale of securities on an exchange or to another person at price $ 27.46 per share.	14 Aug 2020	1,256	2,754 (0%)	0%	27.5	34,490	Common Stock
Ronald Peck	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	14 Aug 2020	4,010	12,031	-		-	Restricted Stock Units
Ronald Peck	Chief Medical Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	14 Aug 2020	4,010	4,010 (0%)	0%		-	Common Stock
Wendy L. Dixon	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Jun 2020	24,000	24,000	-		-	Stock Option (right to buy)
Linda C. Bain	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	10 Jun 2020	24,000	24,000	-		-	Stock Option (right to buy)
Leslie V. Norwalk	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Jun 2020	12,000	12,000	-		-	Stock Option (right to buy)
Liam Ratcliffe	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Jun 2020	12,000	12,000	-		-	Stock Option (right to buy)
Briggs Morrison	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Jun 2020	12,000	12,000	-		-	Stock Option (right to buy)
Laurie Smaldone Alsup	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Jun 2020	12,000	12,000	-		-	Stock Option (right to buy)
Edward Kennedy	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Jun 2020	12,000	12,000	-		-	Stock Option (right to buy)
Jakob Loven	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Jun 2020	12,000	12,000	-		-	Stock Option (right to buy)
Bradley Margus	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	03 Jun 2020	12,000	12,000	-		-	Stock Option (right to buy)
Timothy M. Shannon	Director	Purchase of securities on an exchange or from another person at price $ 32.30 per share.	02 Jun 2020	3,000	77,546 (0%)	0%	32.3	96,900	Common Stock
Timothy M. Shannon	Director	Grant, award, or other acquisition of securities at price $ 0.00 per share.	02 Jun 2020	12,000	12,000	-		-	Stock Option (right to buy)
Timothy M. Shannon	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	26 May 2020	12,923	0	-		-	Stock Option (right to buy)
Timothy M. Shannon	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.06 per share.	26 May 2020	12,923	74,546 (0%)	0%	22.1	285,081	Common Stock
Liam Ratcliffe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.06 per share.	26 May 2020	6,500	6,500 (0%)	0%	22.1	143,390	Common Stock
Liam Ratcliffe	Director	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	26 May 2020	6,500	6,423	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	13 May 2020	1,356	151,778 (0%)	0%	16	21,696	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	13 May 2020	1,139	25,052	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	13 May 2020	217	2,167	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 60.00 per share.	12 May 2020	10,000	150,422 (0%)	0%	60	600,000	Common Stock
Briggs Morrison	Director	Purchase of securities on an exchange or from another person at price $ 38.18 per share.	24 Mar 2020	2,500	29,520 (0%)	0%	38.2	95,450	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	23 Mar 2020	8,030	160,422 (0%)	0%	16	128,480	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	23 Mar 2020	758	2,384	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	23 Mar 2020	1,139	26,191	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	23 Mar 2020	6,133	6,815	-		-	Stock Option (right to buy)
John Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	23 Mar 2020	6,250	88,150	-		-	Stock Option (right to buy)
John Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	23 Mar 2020	6,250	816,200 (2%)	0%	16	100,000	Common Stock
Timothy M. Shannon	Director	Purchase of securities on an exchange or from another person at price $ 40.00 per share.	20 Mar 2020	2,500	61,623 (0%)	0%	40	100,000	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 37.61 per share.	19 Mar 2020	1,514	152,392 (0%)	0%	37.6	56,942	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Mar 2020	4,791	14,374	-		-	Restricted Stock Units
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Mar 2020	4,791	153,906 (0%)	0%		-	Common Stock
John Houston	Director, President and CEO	Sale of securities on an exchange or to another person at price $ 37.61 per share.	19 Mar 2020	5,405	809,950 (2%)	0%	37.6	203,282	Common Stock
John Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Mar 2020	17,511	815,355 (2%)	0%		-	Common Stock
John Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Mar 2020	17,511	52,531	-		-	Restricted Stock Units
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 37.61 per share.	19 Mar 2020	826	70,398 (0%)	0%	37.6	31,066	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Mar 2020	2,686	8,056	-		-	Restricted Stock Units
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	19 Mar 2020	2,686	71,224 (0%)	0%		-	Common Stock
Bradley Margus	Director	Sale of securities on an exchange or to another person at price $ 37.46 per share.	18 Mar 2020	40,000	59,463 (0%)	0%	37.5	1,498,400	Common Stock
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2020	75,000	75,000	-		-	Stock Option (right to buy)
John Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2020	235,000	235,000	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2020	75,000	75,000	-		-	Stock Option (right to buy)
Ronald Peck	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	27 Feb 2020	75,000	75,000	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 50.97 per share.	07 Feb 2020	2,190	152,327 (0%)	0%	51.0	111,624	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 54.10 per share.	07 Feb 2020	30	149,115 (0%)	0%	54.1	1,623	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 52.86 per share.	07 Feb 2020	1,302	149,145 (0%)	0%	52.9	68,824	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 52.30 per share.	07 Feb 2020	1,880	150,447 (0%)	0%	52.3	98,324	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 49.97 per share.	07 Feb 2020	4,598	154,517 (0%)	0%	50.0	229,762	Common Stock
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Jan 2020	1,300	1,300	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	28 Jan 2020	11,742	11,648	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	28 Jan 2020	13,042	68,538 (0%)	0%	16	208,672	Common Stock
John Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	17 Dec 2019	12,500	94,400	-		-	Stock Option (right to buy)
John Houston	Director, President and CEO	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	17 Dec 2019	12,500	797,844 (2%)	0%	16	200,000	Common Stock
Laurie Smaldone Alsup	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	20 Nov 2019	25,846	25,846	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 32.00 per share.	19 Nov 2019	10,000	159,115 (0%)	0%	32	320,000	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 28.00 per share.	13 Nov 2019	10,000	55,496 (0%)	0%	28	280,000	Common Stock
Liam Ratcliffe	None	Purchase of securities on an exchange or from another person at price $ 22.00 per share.	12 Nov 2019	680,000	680,000 (1%)	1%	22	14,960,000	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 24.05 per share.	05 Nov 2019	1,000	65,496 (0%)	0%	24.1	24,050	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 23.55 per share.	05 Nov 2019	9,000	66,496 (0%)	0%	23.6	211,950	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 22.54 per share.	30 Sep 2019	1,300	75,496 (0%)	0%	22.5	29,302	Common Stock
Ian Taylor	Chief Scientific Officer	Sale of securities on an exchange or to another person at price $ 21.76 per share.	30 Sep 2019	8,700	76,796 (0%)	0%	21.8	189,312	Common Stock
Kush M. Parmar	None	Gift of securities by or to the insider at price $ 0.00 per share.	24 Sep 2019	1,700	1,775 (0%)	0%		0	Common Stock
Kush M. Parmar	None	Other type of transaction at price $ 0.00 per share.	16 Sep 2019	3,475	3,475 (0%)	0%		0	Common Stock
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Aug 2019	1,980	0	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Aug 2019	2,058	3,142	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share.	07 Aug 2019	2,212	12,948	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share.	07 Aug 2019	6,250	169,115 (0%)	0%	16	100,000	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 27.04 per share.	29 Jul 2019	1,108	162,925 (0%)	0%	27.0	29,960	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 28.03 per share.	29 Jul 2019	60	162,865 (0%)	0%	28.0	1,682	Common Stock
Sean A. Cassidy	Chief Financial Officer	Sale of securities on an exchange or to another person at price $ 26.13 per share.	29 Jul 2019	10,777	164,033 (0%)	0%	26.1	281,603	Common Stock
Ronald Peck	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Jul 2019	72,184	72,184	-		-	Stock Option (right to buy)
Ronald Peck	Chief Medical Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	29 Jul 2019	16,041	16,041	-		-	Restricted Stock Units
Leslie V. Norwalk	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	24 Jul 2019	25,846	25,846	-		-	Stock Option (right to buy)
John Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	11 Jul 2019	13,360	13,360	-		-	Stock Option (right to buy)
Timothy M. Shannon	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 May 2019	12,923	12,923	-		-	Stock Option (right to buy)
Liam Ratcliffe	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 May 2019	12,923	12,923	-		-	Stock Option (right to buy)
Briggs Morrison	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 May 2019	12,923	12,923	-		-	Stock Option (right to buy)
Kush M. Parmar	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 May 2019	12,923	12,923	-		-	Stock Option (right to buy)
Edward Kennedy	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 May 2019	12,923	12,923	-		-	Stock Option (right to buy)
Jakob Loven	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 May 2019	12,923	12,923	-		-	Stock Option (right to buy)
Bradley Margus	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	23 May 2019	12,923	12,923	-		-	Stock Option (right to buy)
Ian Taylor	Chief Scientific Officer	Purchase of securities on an exchange or from another person at price $ 14.66 per share.	29 Mar 2019	1,000	85,496 (0%)	0%	14.7	14,660	Common Stock
Timothy M. Shannon	None	Purchase of securities on an exchange or from another person at price $ 14.69 per share.	28 Mar 2019	3,500	58,898 (0%)	0%	14.7	51,410	Common Stock
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2019	19,165	19,165	-		-	Restricted Stock Units
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2019	87,752	87,752	-		-	Stock Option (right to buy)
John Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2019	70,042	70,042	-		-	Restricted Stock Units
John Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2019	254,597	254,597	-		-	Stock Option (right to buy)
Andrew Crew	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2019	10,734	10,734	-		-	Restricted Stock Units
Andrew Crew	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2019	776	776	-		-	Restricted Stock Units
Andrew Crew	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2019	60,745	60,745	-		-	Stock Option (right to buy)
Andrew Crew	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2019	1,924	1,924	-		-	Stock Option (right to buy)
Ian Taylor	Senior Vice President, Biology	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2019	65,427	65,427	-		-	Stock Option (right to buy)
Ian Taylor	Senior Vice President, Biology	Grant, award, or other acquisition of securities at price $ 0.00 per share.	01 Mar 2019	10,742	10,742	-		-	Restricted Stock Units
John Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	18 Jan 2019	13,360	13,360	-		-	Stock Option (right to buy)
Timothy M. Shannon	None		01 Oct 2018	4,989,554	4,989,554 (15%)	15%		0	Common Stock
Timothy M. Shannon	None		01 Oct 2018	9,543,387	0	-		-	Series A Preferred Stock
Timothy M. Shannon	None		01 Oct 2018	4,462,837	0	-		-	Series B Preferred Stock
Timothy M. Shannon	None		01 Oct 2018	2,209,833	0	-		-	Series C Preferred Stock
Timothy M. Shannon	None	Purchase of securities on an exchange or from another person at price $ 16.00 per share.	01 Oct 2018	4,000	55,398 (0%)	0%	16	64,000	Common Stock
Sean A. Cassidy	Chief Financial Officer		01 Oct 2018	2,368	0	-		-	Series C Preferred Stock
Sean A. Cassidy	Chief Financial Officer		01 Oct 2018	15,007	0	-		-	Series B Preferred Stock
Sean A. Cassidy	Chief Financial Officer		01 Oct 2018	5,345	174,810 (0%)	0%		0	Common Stock
Sean A. Cassidy	Chief Financial Officer	Purchase of securities on an exchange or from another person at price $ 16.00 per share.	01 Oct 2018	1,600	169,465 (0%)	0%	16	25,600	Common Stock
Flynn E James	Other		01 Oct 2018	998,004	0	-		-	Series C Preferred Stock
Flynn E James	Other	Purchase of securities on an exchange or from another person at price $ 16.00 per share.	01 Oct 2018	104,166	411,244 (1%)	0%	16	1,666,656	Common Stock
Flynn E James	Other	Purchase of securities on an exchange or from another person at price $ 16.00 per share.	01 Oct 2018	104,167	411,245 (1%)	0%	16	1,666,672	Common Stock
Flynn E James	Other	Purchase of securities on an exchange or from another person at price $ 16.00 per share.	01 Oct 2018	104,167	411,245 (1%)	0%	16	1,666,672	Common Stock
Flynn E James	Other		01 Oct 2018	307,078	307,078 (0%)	0%		0	Common Stock
Flynn E James	Other		01 Oct 2018	307,078	307,078 (0%)	0%		0	Common Stock
Flynn E James	Other		01 Oct 2018	307,078	307,078 (0%)	0%		0	Common Stock
Flynn E James	Other		01 Oct 2018	998,004	0	-		-	Series C Preferred Stock
Flynn E James	Other		01 Oct 2018	998,004	0	-		-	Series C Preferred Stock
Liam Ratcliffe	None		01 Oct 2018	568,252	0	-		-	Series C Preferred Stock
Liam Ratcliffe	None		01 Oct 2018	1,108,202	1,108,202 (3%)	3%		0	Common Stock
Liam Ratcliffe	None		01 Oct 2018	3,601,657	0	-		-	Series B Preferred Stock
Liam Ratcliffe	None		01 Oct 2018	174,846	1,283,048 (3%)	0%		0	Common Stock
Liam Ratcliffe	None	Purchase of securities on an exchange or from another person at price $ 16.00 per share.	01 Oct 2018	625,000	1,908,048 (5%)	1%	16	10,000,000	Common Stock
Liam Ratcliffe	None	Purchase of securities on an exchange or from another person at price $ 16.00 per share.	01 Oct 2018	375,000	375,000 (1%)	1%	16	6,000,000	Common Stock
John Houston	Director, President and CEO	Purchase of securities on an exchange or from another person at price $ 16.00 per share.	01 Oct 2018	30,000	772,860 (2%)	0%	16	480,000	Common Stock
John Houston	Director, President and CEO		01 Oct 2018	12,484	785,344 (2%)	0%		0	Common Stock
John Houston	Director, President and CEO		01 Oct 2018	40,573	0	-		-	Series C Preferred Stock
Edward Kennedy	None	Purchase of securities on an exchange or from another person at price $ 16.00 per share.	01 Oct 2018	21,000	34,385 (0%)	0%	16	336,000	Common Stock
Jakob Loven	None	Purchase of securities on an exchange or from another person at price $ 16.00 per share.	01 Oct 2018	312,500	312,500 (0%)	0%	16	5,000,000	Common Stock
Jakob Loven	None		01 Oct 2018	4,491,018	0	-		-	Series C Preferred Stock
Jakob Loven	None		01 Oct 2018	1,381,851	1,694,351 (5%)	4%		0	Common Stock
Bradley Margus	None		01 Oct 2018	18,942	0	-		-	Series C Preferred Stock
Bradley Margus	None		01 Oct 2018	120,055	0	-		-	Series B Preferred Stock
Bradley Margus	None	Purchase of securities on an exchange or from another person at price $ 16.00 per share.	01 Oct 2018	40,000	99,463 (0%)	0%	16	640,000	Common Stock
Bradley Margus	None		01 Oct 2018	42,768	42,768 (0%)	0%		0	Common Stock
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	1,980	1,980	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	5,200	5,200	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	15,160	15,160	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	31,710	31,710	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	27,330	27,330	-		-	Stock Option (right to buy)
Sean A. Cassidy	Chief Financial Officer	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	81,770	81,770	-		-	Stock Option (right to buy)
Briggs Morrison	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	32,870	32,870	-		-	Stock Option (right to buy)
Briggs Morrison	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	6,960	6,960	-		-	Stock Option (right to buy)
John Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	132,880	132,880	-		-	Stock Option (right to buy)
John Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	200,440	200,440	-		-	Stock Option (right to buy)
John Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	13,360	13,360	-		-	Stock Option (right to buy)
John Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	13,360	13,360	-		-	Stock Option (right to buy)
John Houston	Director, President and CEO	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	106,900	106,900	-		-	Stock Option (right to buy)
Andrew Crew	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	15,860	15,860	-		-	Stock Option (right to buy)
Andrew Crew	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	10,390	10,390	-		-	Stock Option (right to buy)
Andrew Crew	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	5,110	5,110	-		-	Stock Option (right to buy)
Andrew Crew	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	34,550	34,550	-		-	Stock Option (right to buy)
Andrew Crew	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	20,440	20,440	-		-	Stock Option (right to buy)
Andrew Crew	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	2,600	2,600	-		-	Stock Option (right to buy)
Andrew Crew	See Remarks	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	5,340	5,340	-		-	Stock Option (right to buy)
Ian Taylor	Senior Vice President, Biology	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	30,660	30,660	-		-	Stock Option (right to buy)
Ian Taylor	Senior Vice President, Biology	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	2,600	2,600	-		-	Stock Option (right to buy)
Ian Taylor	Senior Vice President, Biology	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	23,390	23,390	-		-	Stock Option (right to buy)
Ian Taylor	Senior Vice President, Biology	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	44,390	44,390	-		-	Stock Option (right to buy)
Edward Kennedy	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	32,870	32,870	-		-	Stock Option (right to buy)
Bradley Margus	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	4,660	4,660	-		-	Stock Option (right to buy)
Bradley Margus	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	4,660	4,660	-		-	Stock Option (right to buy)
Bradley Margus	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	4,560	4,560	-		-	Stock Option (right to buy)
Bradley Margus	None	Grant, award, or other acquisition of securities at price $ 0.00 per share.	26 Sep 2018	14,270	14,270	-		-	Stock Option (right to buy)

*All Values are in $ Million

Client Category: Promoter/ KMP/ Director / Immediate Relatives / Employee / etc
Security Type: Share/ Warrants / Convertible Debentures

Data as reported to USA Exchanges

View All The Insider Trades disclosures

80.96% Fall from 52W High

Insider Trading disclosures for Arvinas Inc

The latest disclosure was made by John G. Houston in Arvinas Inc where a trade of 5,154 Common Stock done at an average price of $16.6 was reported to US exchanges on Feb. 24, 2025.

Screeners based on Insider Trading and SAST parameters