XNAS 30 Jul, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2025 | 7,763 | 21,264 (0%) | 0% | 0 | Common Stock | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 119.13 per share. | 30 May 2025 | 12,081 | 61,029 (0%) | 0% | 119.1 | 1,439,210 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 118.05 per share. | 30 May 2025 | 7,217 | 68,245 (0%) | 0% | 118.1 | 851,967 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 306.00 per share. | 30 May 2025 | 19,297 | 48,948 (0%) | 0% | 306 | 5,904,882 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 May 2025 | 19,559 | 8,064 | - | - | Stock Option (right to buy) | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 May 2025 | 7,217 | 847 | - | - | Stock Option (right to buy) | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 May 2025 | 12,081 | 12,919 | - | - | Stock Option (right to buy) | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 May 2025 | 12,080 | 839 | - | - | Stock Option (right to buy) | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 119.13 per share. | 30 May 2025 | 12,080 | 61,028 (0%) | 0% | 119.1 | 1,439,090 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 306.00 per share. | 30 May 2025 | 6,171 | 48,948 (0%) | 0% | 306 | 1,888,326 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 304.00 per share. | 30 May 2025 | 25,469 | 55,119 (0%) | 0% | 304 | 7,742,576 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 118.05 per share. | 30 May 2025 | 19,559 | 80,588 (0%) | 0% | 118.1 | 2,308,940 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 16 May 2025 | 8,376 | 48,948 (0%) | 0% | 0 | Common Stock | |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 273.75 per share. | 15 May 2025 | 882 | 24,558 (0%) | 0% | 273.8 | 241,448 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 273.16 per share. | 15 May 2025 | 660 | 25,440 (0%) | 0% | 273.2 | 180,286 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 271.68 per share. | 15 May 2025 | 431 | 26,100 (0%) | 0% | 271.7 | 117,094 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 269.79 per share. | 15 May 2025 | 245 | 26,531 (0%) | 0% | 269.8 | 66,099 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 268.56 per share. | 15 May 2025 | 729 | 26,776 (0%) | 0% | 268.6 | 195,780 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 277.16 per share. | 15 May 2025 | 1,263 | 22,994 (0%) | 0% | 277.2 | 350,053 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 275.63 per share. | 15 May 2025 | 301 | 24,257 (0%) | 0% | 275.6 | 82,965 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 267.14 per share. | 15 May 2025 | 549 | 27,505 (0%) | 0% | 267.1 | 146,660 | Common Stock |
| Michael W. Bonney | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 131.21 per share. | 15 May 2025 | 11,250 | 28,054 (0%) | 0% | 131.2 | 1,476,113 | Common Stock |
| Michael W. Bonney | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2025 | 11,250 | 0 | - | - | Stock Option (right to buy) | |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 283.83 per share. | 15 May 2025 | 1,617 | 16,804 (0%) | 0% | 283.8 | 458,953 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 282.81 per share. | 15 May 2025 | 1,728 | 18,421 (0%) | 0% | 282.8 | 488,696 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 282.03 per share. | 15 May 2025 | 802 | 20,149 (0%) | 0% | 282.0 | 226,188 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 281.10 per share. | 15 May 2025 | 372 | 20,951 (0%) | 0% | 281.1 | 104,569 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 280.03 per share. | 15 May 2025 | 432 | 21,323 (0%) | 0% | 280.0 | 120,973 | Common Stock |
| Michael W. Bonney | Director | Sale of securities on an exchange or to another person at price $ 278.01 per share. | 15 May 2025 | 1,239 | 21,755 (0%) | 0% | 278.0 | 344,454 | Common Stock |
| Elliott Sigal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 775 | 775 (0%) | 0% | 0 | Common Stock | |
| Elliott Sigal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 1,558 | 1,558 | - | - | Stock Option (right to buy) | |
| Michael W. Bonney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 1,558 | 1,558 | - | - | Stock Option (right to buy) | |
| Michael W. Bonney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 775 | 16,804 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Hamburg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 775 | 911 (0%) | 0% | 0 | Common Stock | |
| Margaret A. Hamburg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 1,558 | 1,558 | - | - | Stock Option (right to buy) | |
| Amy W. Schulman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 775 | 11,961 (0%) | 0% | 0 | Common Stock | |
| Amy W. Schulman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 1,558 | 1,558 | - | - | Stock Option (right to buy) | |
| David E.I. Pyott | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 1,558 | 1,558 | - | - | Stock Option (right to buy) | |
| David E.I. Pyott | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 775 | 911 (0%) | 0% | 0 | Common Stock | |
| Dennis A. Ausiello | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 775 | 911 (0%) | 0% | 0 | Common Stock | |
| Dennis A. Ausiello | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 1,558 | 1,558 | - | - | Stock Option (right to buy) | |
| Peter N. Kellogg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 1,558 | 1,558 | - | - | Stock Option (right to buy) | |
| Peter N. Kellogg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 775 | 775 (0%) | 0% | 0 | Common Stock | |
| Olivier Raymond Brandicourt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 775 | 775 (0%) | 0% | 0 | Common Stock | |
| Olivier Raymond Brandicourt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 1,558 | 1,558 | - | - | Stock Option (right to buy) | |
| Carolyn R. Bertozzi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 1,558 | 1,558 | - | - | Stock Option (right to buy) | |
| Carolyn R. Bertozzi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 May 2025 | 775 | 775 (0%) | 0% | 0 | Common Stock | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 May 2025 | 41,311 | 57,324 (0%) | 0% | 0 | Common Stock | |
| David E.I. Pyott | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 88.95 per share. | 24 Mar 2025 | 7,440 | 7,576 (0%) | 0% | 89.0 | 661,788 | Common Stock |
| David E.I. Pyott | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Mar 2025 | 7,440 | 0 | - | - | Stock Option (right to buy) | |
| David E.I. Pyott | Director | Sale of securities on an exchange or to another person at price $ 299.00 per share. | 24 Mar 2025 | 7,440 | 136 (0%) | 0% | 299 | 2,224,560 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 300.00 per share. | 21 Mar 2025 | 5,445 | 20,221 (0%) | 0% | 300 | 1,633,500 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 42.22 per share. | 21 Mar 2025 | 5,445 | 25,666 (0%) | 0% | 42.2 | 229,888 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 285.00 per share. | 21 Mar 2025 | 4,321 | 20,221 (0%) | 0% | 285 | 1,231,485 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2025 | 5,445 | 0 | - | - | Stock Option (right to buy) | |
| Amy W. Schulman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 131.21 per share. | 13 Mar 2025 | 2,750 | 11,186 (0%) | 0% | 131.2 | 360,828 | Common Stock |
| Amy W. Schulman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Mar 2025 | 2,750 | 0 | - | - | Stock Option (right to buy) | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 247.35 per share. | 03 Mar 2025 | 23 | 98,639 (0%) | 0% | 247.3 | 5,689 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 246.18 per share. | 03 Mar 2025 | 238 | 98,662 (0%) | 0% | 246.2 | 58,591 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 245.26 per share. | 03 Mar 2025 | 580 | 98,900 (0%) | 0% | 245.3 | 142,251 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 244.41 per share. | 03 Mar 2025 | 791 | 99,480 (0%) | 0% | 244.4 | 193,328 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 243.36 per share. | 03 Mar 2025 | 1,173 | 100,271 (0%) | 0% | 243.4 | 285,461 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 242.37 per share. | 03 Mar 2025 | 1,068 | 101,444 (0%) | 0% | 242.4 | 258,851 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 17,965 | 102,512 (0%) | 0% | 0 | Common Stock | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 36,293 | 36,293 | - | - | Stock Option (right to buy) | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 248.25 per share. | 03 Mar 2025 | 4 | 98,635 (0%) | 0% | 248.3 | 993 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 243.36 per share. | 03 Mar 2025 | 382 | 48,283 (0%) | 0% | 243.4 | 92,964 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 245.26 per share. | 03 Mar 2025 | 189 | 47,836 (0%) | 0% | 245.3 | 46,354 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 246.18 per share. | 03 Mar 2025 | 77 | 47,759 (0%) | 0% | 246.2 | 18,956 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 15,117 | 49,015 (0%) | 0% | 0 | Common Stock | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 247.29 per share. | 03 Mar 2025 | 7 | 47,752 (0%) | 0% | 247.3 | 1,731 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 248.00 per share. | 03 Mar 2025 | 1 | 47,751 (0%) | 0% | 248 | 248 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 9,800 | 9,800 | - | - | Stock Option (right to buy) | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 242.37 per share. | 03 Mar 2025 | 350 | 48,665 (0%) | 0% | 242.4 | 84,830 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 244.41 per share. | 03 Mar 2025 | 258 | 48,025 (0%) | 0% | 244.4 | 63,058 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 244.41 per share. | 03 Mar 2025 | 158 | 26,493 (0%) | 0% | 244.4 | 38,617 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 7,819 | 7,819 | - | - | Stock Option (right to buy) | |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 242.70 per share. | 03 Mar 2025 | 120 | 24,542 (0%) | 0% | 242.7 | 29,124 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 241.60 per share. | 03 Mar 2025 | 198 | 24,662 (0%) | 0% | 241.6 | 47,837 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 240.92 per share. | 03 Mar 2025 | 343 | 24,860 (0%) | 0% | 240.9 | 82,636 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 239.25 per share. | 03 Mar 2025 | 147 | 25,203 (0%) | 0% | 239.3 | 35,170 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 245.53 per share. | 03 Mar 2025 | 117 | 25,350 (0%) | 0% | 245.5 | 28,727 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 244.43 per share. | 03 Mar 2025 | 273 | 25,467 (0%) | 0% | 244.4 | 66,729 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 243.13 per share. | 03 Mar 2025 | 583 | 25,740 (0%) | 0% | 243.1 | 141,745 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 248.00 per share. | 03 Mar 2025 | 1 | 26,323 (0%) | 0% | 248 | 248 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 247.40 per share. | 03 Mar 2025 | 5 | 26,324 (0%) | 0% | 247.4 | 1,237 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 246.19 per share. | 03 Mar 2025 | 48 | 26,329 (0%) | 0% | 246.2 | 11,817 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 245.26 per share. | 03 Mar 2025 | 116 | 26,377 (0%) | 0% | 245.3 | 28,450 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 243.36 per share. | 03 Mar 2025 | 235 | 26,651 (0%) | 0% | 243.4 | 57,190 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 242.37 per share. | 03 Mar 2025 | 213 | 26,886 (0%) | 0% | 242.4 | 51,625 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 14,137 | 27,099 (0%) | 0% | 0 | Common Stock | |
| Tolga Tanguler | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 7,819 | 7,819 | - | - | Stock Option (right to buy) | |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 247.33 per share. | 03 Mar 2025 | 3 | 28,011 (0%) | 0% | 247.3 | 742 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 246.17 per share. | 03 Mar 2025 | 29 | 28,014 (0%) | 0% | 246.2 | 7,139 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 245.26 per share. | 03 Mar 2025 | 70 | 28,043 (0%) | 0% | 245.3 | 17,168 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 244.41 per share. | 03 Mar 2025 | 96 | 28,113 (0%) | 0% | 244.4 | 23,463 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 243.36 per share. | 03 Mar 2025 | 142 | 28,209 (0%) | 0% | 243.4 | 34,557 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 242.37 per share. | 03 Mar 2025 | 131 | 28,351 (0%) | 0% | 242.4 | 31,750 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 14,137 | 28,482 (0%) | 0% | 0 | Common Stock | |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 245.30 per share. | 03 Mar 2025 | 219 | 14,345 (0%) | 0% | 245.3 | 53,721 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 7,819 | 7,819 | - | - | Stock Option (right to buy) | |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 242.93 per share. | 03 Mar 2025 | 71 | 13,501 (0%) | 0% | 242.9 | 17,248 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 241.68 per share. | 03 Mar 2025 | 324 | 13,572 (0%) | 0% | 241.7 | 78,304 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 240.95 per share. | 03 Mar 2025 | 328 | 13,896 (0%) | 0% | 241.0 | 79,032 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 239.24 per share. | 03 Mar 2025 | 121 | 14,224 (0%) | 0% | 239.2 | 28,948 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 243.94 per share. | 03 Mar 2025 | 487 | 14,564 (0%) | 0% | 243.9 | 118,799 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 242.69 per share. | 03 Mar 2025 | 465 | 15,051 (0%) | 0% | 242.7 | 112,851 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 248.00 per share. | 03 Mar 2025 | 1 | 15,516 (0%) | 0% | 248 | 248 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 247.25 per share. | 03 Mar 2025 | 4 | 15,517 (0%) | 0% | 247.3 | 989 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 246.18 per share. | 03 Mar 2025 | 45 | 15,521 (0%) | 0% | 246.2 | 11,078 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 245.26 per share. | 03 Mar 2025 | 111 | 15,566 (0%) | 0% | 245.3 | 27,224 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 244.41 per share. | 03 Mar 2025 | 151 | 15,677 (0%) | 0% | 244.4 | 36,906 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 243.36 per share. | 03 Mar 2025 | 224 | 15,828 (0%) | 0% | 243.4 | 54,513 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 242.37 per share. | 03 Mar 2025 | 204 | 16,052 (0%) | 0% | 242.4 | 49,443 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 3,871 | 16,256 (0%) | 0% | 0 | Common Stock | |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 243.23 per share. | 28 Feb 2025 | 75 | 12,422 (0%) | 0% | 243.2 | 18,242 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 244.11 per share. | 28 Feb 2025 | 37 | 12,385 (0%) | 0% | 244.1 | 9,032 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 242.44 per share. | 28 Feb 2025 | 187 | 12,497 (0%) | 0% | 242.4 | 45,336 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 241.51 per share. | 28 Feb 2025 | 79 | 12,684 (0%) | 0% | 241.5 | 19,079 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 240.31 per share. | 28 Feb 2025 | 48 | 12,763 (0%) | 0% | 240.3 | 11,535 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 239.18 per share. | 28 Feb 2025 | 22 | 12,811 (0%) | 0% | 239.2 | 5,262 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 238.33 per share. | 28 Feb 2025 | 21 | 12,833 (0%) | 0% | 238.3 | 5,005 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 236.52 per share. | 28 Feb 2025 | 27 | 12,854 (0%) | 0% | 236.5 | 6,386 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 242.44 per share. | 27 Feb 2025 | 1,093 | 85,201 (0%) | 0% | 242.4 | 264,987 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 241.51 per share. | 27 Feb 2025 | 461 | 86,294 (0%) | 0% | 241.5 | 111,336 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 240.32 per share. | 27 Feb 2025 | 284 | 86,755 (0%) | 0% | 240.3 | 68,251 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 5,921 | 87,447 (0%) | 0% | 0 | Common Stock | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 236.51 per share. | 27 Feb 2025 | 158 | 87,289 (0%) | 0% | 236.5 | 37,369 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 238.33 per share. | 27 Feb 2025 | 123 | 87,166 (0%) | 0% | 238.3 | 29,315 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 239.18 per share. | 27 Feb 2025 | 127 | 87,039 (0%) | 0% | 239.2 | 30,376 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 5,921 | 5,921 | - | - | Restricted Stock Units | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 244.11 per share. | 27 Feb 2025 | 214 | 84,547 (0%) | 0% | 244.1 | 52,240 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 243.23 per share. | 27 Feb 2025 | 440 | 84,761 (0%) | 0% | 243.2 | 107,021 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 1,908 | 1,908 | - | - | Restricted Stock Units | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 238.32 per share. | 27 Feb 2025 | 34 | 34,618 (0%) | 0% | 238.3 | 8,103 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 239.17 per share. | 27 Feb 2025 | 35 | 34,583 (0%) | 0% | 239.2 | 8,371 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 1,908 | 34,694 (0%) | 0% | 0 | Common Stock | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 236.50 per share. | 27 Feb 2025 | 42 | 34,652 (0%) | 0% | 236.5 | 9,933 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 240.32 per share. | 27 Feb 2025 | 78 | 34,505 (0%) | 0% | 240.3 | 18,745 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 241.51 per share. | 27 Feb 2025 | 127 | 34,378 (0%) | 0% | 241.5 | 30,672 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 242.44 per share. | 27 Feb 2025 | 300 | 34,078 (0%) | 0% | 242.4 | 72,732 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 243.23 per share. | 27 Feb 2025 | 121 | 33,957 (0%) | 0% | 243.2 | 29,431 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 244.10 per share. | 27 Feb 2025 | 59 | 33,898 (0%) | 0% | 244.1 | 14,402 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 238.32 per share. | 27 Feb 2025 | 40 | 13,806 (0%) | 0% | 238.3 | 9,533 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 1,908 | 1,908 | - | - | Restricted Stock Units | |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 244.12 per share. | 27 Feb 2025 | 69 | 12,962 (0%) | 0% | 244.1 | 16,844 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 243.23 per share. | 27 Feb 2025 | 142 | 13,031 (0%) | 0% | 243.2 | 34,539 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 242.44 per share. | 27 Feb 2025 | 352 | 13,173 (0%) | 0% | 242.4 | 85,339 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 241.51 per share. | 27 Feb 2025 | 149 | 13,525 (0%) | 0% | 241.5 | 35,985 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 240.32 per share. | 27 Feb 2025 | 91 | 13,674 (0%) | 0% | 240.3 | 21,869 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 239.17 per share. | 27 Feb 2025 | 41 | 13,765 (0%) | 0% | 239.2 | 9,806 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 236.51 per share. | 27 Feb 2025 | 51 | 13,846 (0%) | 0% | 236.5 | 12,062 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 1,908 | 13,897 (0%) | 0% | 0 | Common Stock | |
| Tolga Tanguler | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 1,667 | 1,666 | - | - | Restricted Stock Units | |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 244.11 per share. | 27 Feb 2025 | 38 | 14,345 (0%) | 0% | 244.1 | 9,276 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 243.23 per share. | 27 Feb 2025 | 78 | 14,383 (0%) | 0% | 243.2 | 18,972 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 242.44 per share. | 27 Feb 2025 | 192 | 14,461 (0%) | 0% | 242.4 | 46,548 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 241.51 per share. | 27 Feb 2025 | 82 | 14,653 (0%) | 0% | 241.5 | 19,804 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 240.32 per share. | 27 Feb 2025 | 50 | 14,735 (0%) | 0% | 240.3 | 12,016 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 239.17 per share. | 27 Feb 2025 | 23 | 14,785 (0%) | 0% | 239.2 | 5,501 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 238.32 per share. | 27 Feb 2025 | 22 | 14,808 (0%) | 0% | 238.3 | 5,243 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 236.50 per share. | 27 Feb 2025 | 28 | 14,830 (0%) | 0% | 236.5 | 6,622 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2025 | 1,667 | 14,858 (0%) | 0% | 0 | Common Stock | |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 258.06 per share. | 13 Feb 2025 | 77 | 13,732 (0%) | 0% | 258.1 | 19,871 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 257.52 per share. | 13 Feb 2025 | 60 | 13,809 (0%) | 0% | 257.5 | 15,451 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 256.29 per share. | 13 Feb 2025 | 126 | 13,869 (0%) | 0% | 256.3 | 32,293 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2025 | 3,109 | 15,098 (0%) | 0% | 0 | Common Stock | |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 252.50 per share. | 13 Feb 2025 | 349 | 14,749 (0%) | 0% | 252.5 | 88,123 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 253.37 per share. | 13 Feb 2025 | 386 | 14,363 (0%) | 0% | 253.4 | 97,801 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 254.35 per share. | 13 Feb 2025 | 258 | 14,105 (0%) | 0% | 254.3 | 65,622 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 250.11 per share. | 13 Feb 2025 | 862 | 12,675 (0%) | 0% | 250.1 | 215,595 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 264.88 per share. | 13 Feb 2025 | 32 | 13,537 (0%) | 0% | 264.9 | 8,476 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 263.33 per share. | 13 Feb 2025 | 27 | 13,569 (0%) | 0% | 263.3 | 7,110 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 261.45 per share. | 13 Feb 2025 | 60 | 13,596 (0%) | 0% | 261.5 | 15,687 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 259.10 per share. | 13 Feb 2025 | 80 | 11,989 (0%) | 0% | 259.1 | 20,728 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 257.99 per share. | 13 Feb 2025 | 107 | 12,069 (0%) | 0% | 258.0 | 27,605 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 256.05 per share. | 13 Feb 2025 | 83 | 12,176 (0%) | 0% | 256.0 | 21,252 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 251.60 per share. | 13 Feb 2025 | 110 | 12,259 (0%) | 0% | 251.6 | 27,676 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 250.73 per share. | 13 Feb 2025 | 306 | 12,369 (0%) | 0% | 250.7 | 76,723 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 255.56 per share. | 13 Feb 2025 | 110 | 13,995 (0%) | 0% | 255.6 | 28,112 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 260.57 per share. | 13 Feb 2025 | 49 | 13,656 (0%) | 0% | 260.6 | 12,768 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 259.70 per share. | 13 Feb 2025 | 27 | 13,705 (0%) | 0% | 259.7 | 7,012 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 251.60 per share. | 13 Feb 2025 | 115 | 13,120 (0%) | 0% | 251.6 | 28,934 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2025 | 2,103 | 14,984 (0%) | 0% | 0 | Common Stock | |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 252.50 per share. | 13 Feb 2025 | 145 | 14,839 (0%) | 0% | 252.5 | 36,613 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 253.37 per share. | 13 Feb 2025 | 164 | 14,675 (0%) | 0% | 253.4 | 41,553 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 254.35 per share. | 13 Feb 2025 | 110 | 14,565 (0%) | 0% | 254.4 | 27,979 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 255.55 per share. | 13 Feb 2025 | 47 | 14,518 (0%) | 0% | 255.6 | 12,011 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 256.28 per share. | 13 Feb 2025 | 53 | 14,465 (0%) | 0% | 256.3 | 13,583 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 257.50 per share. | 13 Feb 2025 | 26 | 14,439 (0%) | 0% | 257.5 | 6,695 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 258.06 per share. | 13 Feb 2025 | 33 | 14,406 (0%) | 0% | 258.1 | 8,516 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 259.75 per share. | 13 Feb 2025 | 12 | 14,394 (0%) | 0% | 259.8 | 3,117 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 260.57 per share. | 13 Feb 2025 | 21 | 14,373 (0%) | 0% | 260.6 | 5,472 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 261.46 per share. | 13 Feb 2025 | 26 | 14,347 (0%) | 0% | 261.5 | 6,798 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 263.33 per share. | 13 Feb 2025 | 12 | 14,335 (0%) | 0% | 263.3 | 3,160 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 264.86 per share. | 13 Feb 2025 | 14 | 14,321 (0%) | 0% | 264.9 | 3,708 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 250.21 per share. | 13 Feb 2025 | 1,086 | 13,235 (0%) | 0% | 250.2 | 271,728 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 256.05 per share. | 13 Feb 2025 | 80 | 13,040 (0%) | 0% | 256.1 | 20,484 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 257.79 per share. | 13 Feb 2025 | 76 | 12,964 (0%) | 0% | 257.8 | 19,592 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 259.10 per share. | 13 Feb 2025 | 83 | 12,881 (0%) | 0% | 259.1 | 21,505 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 259.71 per share. | 13 Feb 2025 | 21 | 81,657 (0%) | 0% | 259.7 | 5,454 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 258.07 per share. | 13 Feb 2025 | 59 | 81,678 (0%) | 0% | 258.1 | 15,226 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 257.51 per share. | 13 Feb 2025 | 47 | 81,737 (0%) | 0% | 257.5 | 12,103 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 256.29 per share. | 13 Feb 2025 | 98 | 81,784 (0%) | 0% | 256.3 | 25,116 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 255.56 per share. | 13 Feb 2025 | 85 | 81,882 (0%) | 0% | 255.6 | 21,723 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 254.35 per share. | 13 Feb 2025 | 201 | 81,967 (0%) | 0% | 254.3 | 51,124 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 253.37 per share. | 13 Feb 2025 | 300 | 82,168 (0%) | 0% | 253.4 | 76,011 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 252.50 per share. | 13 Feb 2025 | 271 | 82,468 (0%) | 0% | 252.5 | 68,428 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2025 | 3,859 | 82,739 (0%) | 0% | 0 | Common Stock | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 264.88 per share. | 13 Feb 2025 | 25 | 81,526 (0%) | 0% | 264.9 | 6,622 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 263.33 per share. | 13 Feb 2025 | 21 | 81,551 (0%) | 0% | 263.3 | 5,530 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 261.45 per share. | 13 Feb 2025 | 47 | 81,572 (0%) | 0% | 261.4 | 12,288 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 260.58 per share. | 13 Feb 2025 | 38 | 81,619 (0%) | 0% | 260.6 | 9,902 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 259.71 per share. | 13 Feb 2025 | 17 | 32,890 (0%) | 0% | 259.7 | 4,415 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2025 | 3,109 | 33,753 (0%) | 0% | 0 | Common Stock | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 252.50 per share. | 13 Feb 2025 | 217 | 33,536 (0%) | 0% | 252.5 | 54,793 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 253.37 per share. | 13 Feb 2025 | 239 | 33,297 (0%) | 0% | 253.4 | 60,555 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 264.85 per share. | 13 Feb 2025 | 20 | 32,786 (0%) | 0% | 264.9 | 5,297 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 263.35 per share. | 13 Feb 2025 | 17 | 32,806 (0%) | 0% | 263.4 | 4,477 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 261.46 per share. | 13 Feb 2025 | 37 | 32,823 (0%) | 0% | 261.5 | 9,674 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 260.57 per share. | 13 Feb 2025 | 30 | 32,860 (0%) | 0% | 260.6 | 7,817 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 258.06 per share. | 13 Feb 2025 | 47 | 32,907 (0%) | 0% | 258.1 | 12,129 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 257.51 per share. | 13 Feb 2025 | 37 | 32,954 (0%) | 0% | 257.5 | 9,528 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 256.29 per share. | 13 Feb 2025 | 78 | 32,991 (0%) | 0% | 256.3 | 19,991 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 255.56 per share. | 13 Feb 2025 | 68 | 33,069 (0%) | 0% | 255.6 | 17,378 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 254.35 per share. | 13 Feb 2025 | 160 | 33,137 (0%) | 0% | 254.4 | 40,696 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 23,876 | 0 | - | - | Stock Option (right to buy) | |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 285.00 per share. | 27 Jan 2025 | 52,592 | 11,989 (0%) | 0% | 285 | 14,988,720 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 25,000 | 0 | - | - | Performance Stock Option 2015 (right to buy) | |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 88.95 per share. | 27 Jan 2025 | 23,876 | 39,581 (0%) | 0% | 88.9 | 2,123,770 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 88.95 per share. | 27 Jan 2025 | 25,000 | 64,581 (0%) | 0% | 89.0 | 2,223,750 | Common Stock |
| Phillip A. Sharp | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 131.21 per share. | 23 Jan 2025 | 11,250 | 11,250 (0%) | 0% | 131.2 | 1,476,113 | Common Stock |
| Phillip A. Sharp | Director | Sale of securities on an exchange or to another person at price $ 275.00 per share. | 23 Jan 2025 | 11,250 | 0 (0%) | 0% | 275 | 3,093,750 | Common Stock |
| Phillip A. Sharp | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2025 | 11,250 | 0 | - | - | Stock Option (right to buy) | |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 250.08 per share. | 12 Dec 2024 | 426 | 16,724 (0%) | 0% | 250.1 | 106,534 | Common Stock |
| P. Pushkal Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 248.99 per share. | 12 Dec 2024 | 186 | 17,150 (0%) | 0% | 249.0 | 46,312 | Common Stock |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 254.37 per share. | 12 Dec 2024 | 140 | 15,706 (0%) | 0% | 254.4 | 35,612 | Common Stock |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 256.00 per share. | 12 Dec 2024 | 1 | 15,705 (0%) | 0% | 256 | 256 | Common Stock |
| P. Pushkal Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 251.68 per share. | 12 Dec 2024 | 778 | 15,946 (0%) | 0% | 251.7 | 195,807 | Common Stock |
| Garg P. Pushkal | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 247.48 per share. | 12 Dec 2024 | 121 | 17,336 (0%) | 0% | 247.5 | 29,945 | Common Stock |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 252.94 per share. | 12 Dec 2024 | 100 | 15,846 (0%) | 0% | 252.9 | 25,294 | Common Stock |
| P. Pushkal Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 252.27 per share. | 25 Nov 2024 | 97 | 17,457 (0%) | 0% | 252.3 | 24,470 | Common Stock |
| Greenstreet L Yvonne | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 250.68 per share. | 25 Nov 2024 | 1,131 | 82,113 (0%) | 0% | 250.7 | 283,519 | Common Stock |
| Joseph Fitzgerald Kevin | CSO & EVP, Head of Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Nov 2024 | 3,000 | 15,881 (0%) | 0% | 0 | Common Stock | |
| Tanguler Tolga | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 247.77 per share. | 25 Nov 2024 | 26 | 14,634 (0%) | 0% | 247.8 | 6,442 | Common Stock |
| Fitzgerald Joseph Kevin | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 254.48 per share. | 25 Nov 2024 | 110 | 12,881 (0%) | 0% | 254.5 | 27,993 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 250.68 per share. | 25 Nov 2024 | 318 | 14,101 (0%) | 0% | 250.7 | 79,716 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Nov 2024 | 3,434 | 32,326 (0%) | 0% | 0 | Common Stock | |
| Garg P. Pushkal | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 249.60 per share. | 25 Nov 2024 | 246 | 18,863 (0%) | 0% | 249.6 | 61,402 | Common Stock |
| Kevin Fitzgerald Joseph | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 247.77 per share. | 25 Nov 2024 | 26 | 15,855 (0%) | 0% | 247.8 | 6,442 | Common Stock |
| Greenstreet L Yvonne | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 247.77 per share. | 25 Nov 2024 | 93 | 84,006 (0%) | 0% | 247.8 | 23,043 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 250.68 per share. | 25 Nov 2024 | 364 | 18,499 (0%) | 0% | 250.7 | 91,248 | Common Stock |
| Yvonne Greenstreet L | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Nov 2024 | 10,658 | 84,099 (0%) | 0% | 0 | Common Stock | |
| Yvonne Greenstreet L | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 252.27 per share. | 25 Nov 2024 | 300 | 78,880 (0%) | 0% | 252.3 | 75,681 | Common Stock |
| V. Poulton Jeffrey | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 249.60 per share. | 25 Nov 2024 | 246 | 32,050 (0%) | 0% | 249.6 | 61,402 | Common Stock |
| P. Pushkal Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 247.77 per share. | 25 Nov 2024 | 30 | 19,109 (0%) | 0% | 247.8 | 7,433 | Common Stock |
| Joseph Fitzgerald Kevin | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 249.60 per share. | 25 Nov 2024 | 215 | 15,640 (0%) | 0% | 249.6 | 53,664 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 249.60 per share. | 25 Nov 2024 | 215 | 14,419 (0%) | 0% | 249.6 | 53,664 | Common Stock |
| Kevin Fitzgerald Joseph | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 251.98 per share. | 25 Nov 2024 | 851 | 13,351 (0%) | 0% | 252.0 | 214,435 | Common Stock |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 251.42 per share. | 25 Nov 2024 | 945 | 17,554 (0%) | 0% | 251.4 | 237,592 | Common Stock |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 252.27 per share. | 25 Nov 2024 | 97 | 30,644 (0%) | 0% | 252.3 | 24,470 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 252.27 per share. | 25 Nov 2024 | 84 | 14,412 (0%) | 0% | 252.3 | 21,191 | Common Stock |
| Kevin Fitzgerald Joseph | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 251.42 per share. | 25 Nov 2024 | 826 | 14,496 (0%) | 0% | 251.4 | 207,673 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 253.44 per share. | 25 Nov 2024 | 360 | 12,991 (0%) | 0% | 253.4 | 91,238 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 249.60 per share. | 25 Nov 2024 | 762 | 83,244 (0%) | 0% | 249.6 | 190,195 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 252.27 per share. | 25 Nov 2024 | 84 | 13,191 (0%) | 0% | 252.3 | 21,191 | Common Stock |
| Fitzgerald Joseph Kevin | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 250.68 per share. | 25 Nov 2024 | 318 | 15,322 (0%) | 0% | 250.7 | 79,716 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 247.77 per share. | 25 Nov 2024 | 30 | 32,296 (0%) | 0% | 247.8 | 7,433 | Common Stock |
| Greenstreet Yvonne L | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 251.42 per share. | 25 Nov 2024 | 2,933 | 79,180 (0%) | 0% | 251.4 | 737,415 | Common Stock |
| V. Poulton Jeffrey | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 251.42 per share. | 25 Nov 2024 | 945 | 30,741 (0%) | 0% | 251.4 | 237,592 | Common Stock |
| Tanguler Tolga | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 251.42 per share. | 25 Nov 2024 | 826 | 13,275 (0%) | 0% | 251.4 | 207,673 | Common Stock |
| Kevin Fitzgerald Joseph | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 250.45 per share. | 25 Nov 2024 | 210 | 14,202 (0%) | 0% | 250.5 | 52,595 | Common Stock |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Nov 2024 | 3,434 | 19,139 (0%) | 0% | 0 | Common Stock | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 250.68 per share. | 25 Nov 2024 | 364 | 31,686 (0%) | 0% | 250.7 | 91,248 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Nov 2024 | 3,000 | 14,660 (0%) | 0% | 0 | Common Stock | |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Oct 2024 | 96 | 15,705 (0%) | 0% | 0 | Common Stock | |
| Colleen F. Reitan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Aug 2024 | 775 | 775 (0%) | 0% | 0 | Common Stock | |
| Colleen F. Reitan | Director | Sale of securities on an exchange or to another person at price $ 232.86 per share. | 29 Aug 2024 | 36 | 0 (0%) | 0% | 232.9 | 8,383 | Common Stock |
| Colleen F. Reitan | Director | Purchase of securities on an exchange or from another person at price $ 286.00 per share. | 29 Aug 2024 | 32 | 32 (0%) | 0% | 286 | 9,152 | Common Stock |
| Colleen F. Reitan | Director | Purchase of securities on an exchange or from another person at price $ 302.75 per share. | 29 Aug 2024 | 4 | 36 (0%) | 0% | 302.8 | 1,211 | Common Stock |
| Colleen F. Reitan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Aug 2024 | 1,558 | 1,558 | - | - | Stock Option (right to buy) | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 280.00 per share. | 20 Aug 2024 | 15,000 | 73,441 (0%) | 0% | 280 | 4,200,000 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 85.00 per share. | 20 Aug 2024 | 15,000 | 88,441 (0%) | 0% | 85 | 1,275,000 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Aug 2024 | 15,000 | 2,352 | - | - | Stock Option (right to buy) | |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 97.72 per share. | 12 Aug 2024 | 6,667 | 20,848 (0%) | 0% | 97.7 | 651,499 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2024 | 6,667 | 0 | - | - | Stock Option (right to buy) | |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2024 | 14,058 | 2,192 | - | - | Stock Option (right to buy) | |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 274.65 per share. | 12 Aug 2024 | 135 | 12,881 (0%) | 0% | 274.7 | 37,078 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 273.73 per share. | 12 Aug 2024 | 1,158 | 13,016 (0%) | 0% | 273.7 | 316,979 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 272.43 per share. | 12 Aug 2024 | 3,913 | 14,174 (0%) | 0% | 272.4 | 1,066,019 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 271.32 per share. | 12 Aug 2024 | 5,736 | 18,087 (0%) | 0% | 271.3 | 1,556,292 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 270.17 per share. | 12 Aug 2024 | 9,662 | 23,823 (0%) | 0% | 270.2 | 2,610,383 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 268.66 per share. | 12 Aug 2024 | 1,421 | 33,485 (0%) | 0% | 268.7 | 381,766 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Exercise or conversion of derivative security received from the company (such as an option) at price $ 85.00 per share. | 12 Aug 2024 | 14,058 | 34,906 (0%) | 0% | 85 | 1,194,930 | Common Stock |
| Dennis A. Ausiello | Director | Sale of securities on an exchange or to another person at price $ 263.72 per share. | 06 Aug 2024 | 3,408 | 1,030 (0%) | 0% | 263.7 | 898,758 | Common Stock |
| Dennis A. Ausiello | Director | Sale of securities on an exchange or to another person at price $ 264.95 per share. | 06 Aug 2024 | 632 | 398 (0%) | 0% | 264.9 | 167,448 | Common Stock |
| Dennis A. Ausiello | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2024 | 9,000 | 0 | - | - | Stock Option (right to buy) | |
| Dennis A. Ausiello | Director | Sale of securities on an exchange or to another person at price $ 266.45 per share. | 06 Aug 2024 | 262 | 136 (0%) | 0% | 266.5 | 69,810 | Common Stock |
| Dennis A. Ausiello | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Aug 2024 | 11,250 | 0 | - | - | Stock Option (right to buy) | |
| Dennis A. Ausiello | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 131.21 per share. | 06 Aug 2024 | 11,250 | 11,386 (0%) | 0% | 131.2 | 1,476,113 | Common Stock |
| Dennis A. Ausiello | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 105.26 per share. | 06 Aug 2024 | 9,000 | 20,386 (0%) | 0% | 105.3 | 947,340 | Common Stock |
| Dennis A. Ausiello | Director | Sale of securities on an exchange or to another person at price $ 259.56 per share. | 06 Aug 2024 | 1,627 | 18,759 (0%) | 0% | 259.6 | 422,304 | Common Stock |
| Dennis A. Ausiello | Director | Sale of securities on an exchange or to another person at price $ 260.40 per share. | 06 Aug 2024 | 3,742 | 15,017 (0%) | 0% | 260.4 | 974,417 | Common Stock |
| Dennis A. Ausiello | Director | Sale of securities on an exchange or to another person at price $ 261.63 per share. | 06 Aug 2024 | 6,212 | 8,805 (0%) | 0% | 261.6 | 1,625,246 | Common Stock |
| Dennis A. Ausiello | Director | Sale of securities on an exchange or to another person at price $ 262.79 per share. | 06 Aug 2024 | 4,367 | 4,438 (0%) | 0% | 262.8 | 1,147,604 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 270.00 per share. | 01 Aug 2024 | 15,148 | 73,441 (0%) | 0% | 270 | 4,089,960 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 85.00 per share. | 01 Aug 2024 | 15,148 | 88,589 (0%) | 0% | 85 | 1,287,580 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 15,148 | 17,352 | - | - | Stock Option (right to buy) | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 261.00 per share. | 11 Jul 2024 | 7,093 | 73,441 (0%) | 0% | 261 | 1,851,273 | Common Stock |
| Amy W. Schulman | Director | Sale of securities on an exchange or to another person at price $ 240.00 per share. | 25 Jun 2024 | 8,500 | 8,436 (0%) | 0% | 240 | 2,040,000 | Common Stock |
| Amy W. Schulman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 131.21 per share. | 25 Jun 2024 | 8,500 | 16,936 (0%) | 0% | 131.2 | 1,115,285 | Common Stock |
| Amy W. Schulman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Jun 2024 | 8,500 | 2,750 | - | - | Stock Option (right to buy) | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 224.17 per share. | 24 Jun 2024 | 66 | 88,461 (0%) | 0% | 224.2 | 14,795 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 225.55 per share. | 24 Jun 2024 | 93 | 88,368 (0%) | 0% | 225.5 | 20,976 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 226.82 per share. | 24 Jun 2024 | 177 | 88,191 (0%) | 0% | 226.8 | 40,147 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 228.30 per share. | 24 Jun 2024 | 666 | 87,525 (0%) | 0% | 228.3 | 152,048 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 229.06 per share. | 24 Jun 2024 | 1,374 | 86,151 (0%) | 0% | 229.1 | 314,728 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 229.93 per share. | 24 Jun 2024 | 1,572 | 84,579 (0%) | 0% | 229.9 | 361,450 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 231.59 per share. | 24 Jun 2024 | 511 | 84,068 (0%) | 0% | 231.6 | 118,342 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 232.54 per share. | 24 Jun 2024 | 1,119 | 82,949 (0%) | 0% | 232.5 | 260,212 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 233.53 per share. | 24 Jun 2024 | 595 | 82,354 (0%) | 0% | 233.5 | 138,950 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 234.66 per share. | 24 Jun 2024 | 957 | 81,397 (0%) | 0% | 234.7 | 224,570 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 235.19 per share. | 24 Jun 2024 | 863 | 80,534 (0%) | 0% | 235.2 | 202,969 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2024 | 16,953 | 88,835 (0%) | 0% | 0 | Common Stock | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 221.71 per share. | 24 Jun 2024 | 308 | 88,527 (0%) | 0% | 221.7 | 68,287 | Common Stock |
| David E.I. Pyott | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 70.20 per share. | 24 Jun 2024 | 7,420 | 25,116 (0%) | 0% | 70.2 | 520,884 | Common Stock |
| David E.I. Pyott | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 17,560 | 7,440 | - | - | Stock Option (right to buy) | |
| David E.I. Pyott | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 7,470 | 3,780 | - | - | Stock Option (right to buy) | |
| David E.I. Pyott | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2024 | 7,420 | 3,830 | - | - | Stock Option (right to buy) | |
| David E.I. Pyott | Director | Sale of securities on an exchange or to another person at price $ 222.00 per share. | 24 Jun 2024 | 7,470 | 136 (0%) | 0% | 222 | 1,658,340 | Common Stock |
| David E.I. Pyott | Director | Sale of securities on an exchange or to another person at price $ 221.00 per share. | 24 Jun 2024 | 7,420 | 7,606 (0%) | 0% | 221 | 1,639,820 | Common Stock |
| David E.I. Pyott | Director | Sale of securities on an exchange or to another person at price $ 220.00 per share. | 24 Jun 2024 | 17,560 | 15,026 (0%) | 0% | 220 | 3,863,200 | Common Stock |
| David E.I. Pyott | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 71.99 per share. | 24 Jun 2024 | 7,470 | 32,586 (0%) | 0% | 72.0 | 537,765 | Common Stock |
| David E.I. Pyott | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 88.95 per share. | 24 Jun 2024 | 17,560 | 17,696 (0%) | 0% | 89.0 | 1,561,962 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 232.54 per share. | 24 Jun 2024 | 216 | 29,359 (0%) | 0% | 232.5 | 50,229 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 233.53 per share. | 24 Jun 2024 | 115 | 29,244 (0%) | 0% | 233.5 | 26,856 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 234.66 per share. | 24 Jun 2024 | 185 | 29,059 (0%) | 0% | 234.7 | 43,412 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 235.19 per share. | 24 Jun 2024 | 167 | 28,892 (0%) | 0% | 235.2 | 39,277 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2024 | 3,278 | 30,497 (0%) | 0% | 0 | Common Stock | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 221.71 per share. | 24 Jun 2024 | 59 | 30,438 (0%) | 0% | 221.7 | 13,081 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 224.15 per share. | 24 Jun 2024 | 13 | 30,425 (0%) | 0% | 224.2 | 2,914 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 225.56 per share. | 24 Jun 2024 | 18 | 30,407 (0%) | 0% | 225.6 | 4,060 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 226.82 per share. | 24 Jun 2024 | 34 | 30,373 (0%) | 0% | 226.8 | 7,712 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 228.30 per share. | 24 Jun 2024 | 129 | 30,244 (0%) | 0% | 228.3 | 29,451 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 229.06 per share. | 24 Jun 2024 | 266 | 29,978 (0%) | 0% | 229.1 | 60,930 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 229.93 per share. | 24 Jun 2024 | 304 | 29,674 (0%) | 0% | 229.9 | 69,899 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 231.59 per share. | 24 Jun 2024 | 99 | 29,575 (0%) | 0% | 231.6 | 22,927 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 235.19 per share. | 24 Jun 2024 | 219 | 15,609 (0%) | 0% | 235.2 | 51,507 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 234.66 per share. | 24 Jun 2024 | 242 | 15,828 (0%) | 0% | 234.7 | 56,788 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 233.53 per share. | 24 Jun 2024 | 151 | 16,070 (0%) | 0% | 233.5 | 35,263 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 232.54 per share. | 24 Jun 2024 | 283 | 16,221 (0%) | 0% | 232.5 | 65,809 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 231.59 per share. | 24 Jun 2024 | 129 | 16,504 (0%) | 0% | 231.6 | 29,875 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 229.93 per share. | 24 Jun 2024 | 398 | 16,633 (0%) | 0% | 229.9 | 91,512 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 229.06 per share. | 24 Jun 2024 | 348 | 17,031 (0%) | 0% | 229.1 | 79,713 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 228.30 per share. | 24 Jun 2024 | 169 | 17,379 (0%) | 0% | 228.3 | 38,583 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 226.82 per share. | 24 Jun 2024 | 45 | 17,548 (0%) | 0% | 226.8 | 10,207 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 225.54 per share. | 24 Jun 2024 | 24 | 17,593 (0%) | 0% | 225.5 | 5,413 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 224.18 per share. | 24 Jun 2024 | 17 | 17,617 (0%) | 0% | 224.2 | 3,811 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 221.71 per share. | 24 Jun 2024 | 78 | 17,634 (0%) | 0% | 221.7 | 17,293 | Common Stock |
| Pushkal P. Garg | CMO & EVP Dev & Med Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2024 | 4,295 | 17,712 (0%) | 0% | 0 | Common Stock | |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 231.59 per share. | 24 Jun 2024 | 99 | 12,343 (0%) | 0% | 231.6 | 22,927 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2024 | 3,278 | 13,265 (0%) | 0% | 0 | Common Stock | |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 221.71 per share. | 24 Jun 2024 | 59 | 13,206 (0%) | 0% | 221.7 | 13,081 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 224.15 per share. | 24 Jun 2024 | 13 | 13,193 (0%) | 0% | 224.2 | 2,914 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 225.56 per share. | 24 Jun 2024 | 18 | 13,175 (0%) | 0% | 225.6 | 4,060 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 226.82 per share. | 24 Jun 2024 | 34 | 13,141 (0%) | 0% | 226.8 | 7,712 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 228.30 per share. | 24 Jun 2024 | 129 | 13,012 (0%) | 0% | 228.3 | 29,451 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 229.06 per share. | 24 Jun 2024 | 266 | 12,746 (0%) | 0% | 229.1 | 60,930 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 229.93 per share. | 24 Jun 2024 | 304 | 12,442 (0%) | 0% | 229.9 | 69,899 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 235.19 per share. | 24 Jun 2024 | 167 | 11,660 (0%) | 0% | 235.2 | 39,277 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 234.66 per share. | 24 Jun 2024 | 185 | 11,827 (0%) | 0% | 234.7 | 43,412 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 233.53 per share. | 24 Jun 2024 | 115 | 12,012 (0%) | 0% | 233.5 | 26,856 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 232.54 per share. | 24 Jun 2024 | 216 | 12,127 (0%) | 0% | 232.5 | 50,229 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 228.30 per share. | 24 Jun 2024 | 96 | 15,190 (0%) | 0% | 228.3 | 21,917 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 225.54 per share. | 24 Jun 2024 | 13 | 15,312 (0%) | 0% | 225.5 | 2,932 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 224.22 per share. | 24 Jun 2024 | 9 | 15,325 (0%) | 0% | 224.2 | 2,018 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 221.71 per share. | 24 Jun 2024 | 45 | 15,334 (0%) | 0% | 221.7 | 9,977 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2024 | 2,498 | 15,379 (0%) | 0% | 0 | Common Stock | |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 235.19 per share. | 24 Jun 2024 | 125 | 14,181 (0%) | 0% | 235.2 | 29,399 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 234.66 per share. | 24 Jun 2024 | 138 | 14,306 (0%) | 0% | 234.7 | 32,383 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 233.53 per share. | 24 Jun 2024 | 86 | 14,444 (0%) | 0% | 233.5 | 20,084 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 232.54 per share. | 24 Jun 2024 | 161 | 14,530 (0%) | 0% | 232.5 | 37,439 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 231.59 per share. | 24 Jun 2024 | 74 | 14,691 (0%) | 0% | 231.6 | 17,138 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 229.93 per share. | 24 Jun 2024 | 227 | 14,765 (0%) | 0% | 229.9 | 52,194 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 229.06 per share. | 24 Jun 2024 | 198 | 14,992 (0%) | 0% | 229.1 | 45,354 | Common Stock |
| Kevin Joseph Fitzgerald | CSO & EVP, Head of Research | Sale of securities on an exchange or to another person at price $ 226.81 per share. | 24 Jun 2024 | 26 | 15,286 (0%) | 0% | 226.8 | 5,897 | Common Stock |
| Amy W. Schulman | Director | Sale of securities on an exchange or to another person at price $ 148.93 per share. | 29 May 2024 | 11,516 | 8,499 (0%) | 0% | 148.9 | 1,715,078 | Common Stock |
| Amy W. Schulman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 May 2024 | 30,000 | 0 | - | - | Stock Option (right to buy) | |
| Amy W. Schulman | Director | Sale of securities on an exchange or to another person at price $ 149.76 per share. | 29 May 2024 | 63 | 8,436 (0%) | 0% | 149.8 | 9,435 | Common Stock |
| Amy W. Schulman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 66.83 per share. | 29 May 2024 | 30,000 | 30,136 (0%) | 0% | 66.8 | 2,004,900 | Common Stock |
| Amy W. Schulman | Director | Sale of securities on an exchange or to another person at price $ 148.21 per share. | 29 May 2024 | 10,121 | 20,015 (0%) | 0% | 148.2 | 1,500,033 | Common Stock |
| Elliott Sigal | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 5,228 | 5,228 | - | - | Stock Option (right to buy) | |
| Michael W. Bonney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 5,228 | 5,228 | - | - | Stock Option (right to buy) | |
| Margaret A. Hamburg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 5,228 | 5,228 | - | - | Stock Option (right to buy) | |
| Phillip A. Sharp | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 5,228 | 5,228 | - | - | Stock Option (right to buy) | |
| Amy W. Schulman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 5,228 | 5,228 | - | - | Stock Option (right to buy) | |
| David E.I. Pyott | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 5,228 | 5,228 | - | - | Stock Option (right to buy) | |
| Dennis A. Ausiello | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 5,228 | 5,228 | - | - | Stock Option (right to buy) | |
| Peter N. Kellogg | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 5,228 | 5,228 | - | - | Stock Option (right to buy) | |
| Olivier Raymond Brandicourt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 5,228 | 5,228 | - | - | Stock Option (right to buy) | |
| Carolyn R. Bertozzi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 5,228 | 5,228 | - | - | Stock Option (right to buy) | |
| Colleen F. Reitan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2024 | 5,228 | 5,228 | - | - | Stock Option (right to buy) | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 23,754 | 71,882 (0%) | 0% | 0 | Common Stock | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 46,394 | 46,394 | - | - | Stock Option (right to buy) | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 7,741 | 27,219 (0%) | 0% | 0 | Common Stock | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 15,118 | 15,118 | - | - | Stock Option (right to buy) | |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 9,279 | 9,279 | - | - | Stock Option (right to buy) | |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 4,751 | 13,417 (0%) | 0% | 0 | Common Stock | |
| Tolga Tanguler | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 9,279 | 9,279 | - | - | Stock Option (right to buy) | |
| Tolga Tanguler | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 4,751 | 9,987 (0%) | 0% | 0 | Common Stock | |
| Phillip A. Sharp | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 59.25 per share. | 29 Feb 2024 | 30,000 | 30,000 (0%) | 0% | 59.3 | 1,777,500 | Common Stock |
| Phillip A. Sharp | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Feb 2024 | 30,000 | 0 | - | - | Stock Option (right to buy) | |
| Phillip A. Sharp | Director | Sale of securities on an exchange or to another person at price $ 156.54 per share. | 29 Feb 2024 | 516 | 0 (0%) | 0% | 156.5 | 80,775 | Common Stock |
| Phillip A. Sharp | Director | Sale of securities on an exchange or to another person at price $ 154.07 per share. | 29 Feb 2024 | 101 | 516 (0%) | 0% | 154.1 | 15,561 | Common Stock |
| Phillip A. Sharp | Director | Sale of securities on an exchange or to another person at price $ 153.62 per share. | 29 Feb 2024 | 1,906 | 617 (0%) | 0% | 153.6 | 292,800 | Common Stock |
| Phillip A. Sharp | Director | Sale of securities on an exchange or to another person at price $ 152.40 per share. | 29 Feb 2024 | 915 | 2,523 (0%) | 0% | 152.4 | 139,446 | Common Stock |
| Phillip A. Sharp | Director | Sale of securities on an exchange or to another person at price $ 151.43 per share. | 29 Feb 2024 | 13,557 | 3,438 (0%) | 0% | 151.4 | 2,052,937 | Common Stock |
| Phillip A. Sharp | Director | Sale of securities on an exchange or to another person at price $ 150.60 per share. | 29 Feb 2024 | 13,005 | 16,995 (0%) | 0% | 150.6 | 1,958,553 | Common Stock |
| Lall Franchini Indrani | EVP, CLO & Secretary | Sale of securities on an exchange or to another person at price $ 158.00 per share. | 27 Feb 2024 | 1 | 4,133 (0%) | 0% | 158 | 158 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 154.54 per share. | 27 Feb 2024 | 216 | 5,521 (0%) | 0% | 154.5 | 33,381 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 157.30 per share. | 27 Feb 2024 | 84 | 48,136 (0%) | 0% | 157.3 | 13,213 | Common Stock |
| Garg Pushkal P. | CMO & EVP Dev & Med Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 1,908 | 3,816 | - | - | Restricted Stock Units | |
| Franchini Lall Indrani | EVP, CLO & Secretary | Sale of securities on an exchange or to another person at price $ 156.38 per share. | 27 Feb 2024 | 66 | 4,143 (0%) | 0% | 156.4 | 10,321 | Common Stock |
| Tanguler Tolga | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 158.00 per share. | 27 Feb 2024 | 1 | 5,236 (0%) | 0% | 158 | 158 | Common Stock |
| Tanguler Tolga | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 1,667 | 5,737 (0%) | 0% | 0 | Common Stock | |
| Franchini Indrani Lall | EVP, CLO & Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 878 | 1,754 | - | - | Restricted Stock Units | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 5,921 | 11,842 | - | - | Restricted Stock Units | |
| L Greenstreet Yvonne | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 5,921 | 51,060 (0%) | 0% | 0 | Common Stock | |
| Indrani Franchini Lall | EVP, CLO & Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 878 | 4,462 (0%) | 0% | 0 | Common Stock | |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 1,908 | 3,816 | - | - | Restricted Stock Units | |
| L Greenstreet Yvonne | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 155.45 per share. | 27 Feb 2024 | 993 | 48,808 (0%) | 0% | 155.5 | 154,362 | Common Stock |
| Garg Pushkal P. | CMO & EVP Dev & Med Affairs | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 1,908 | 9,240 (0%) | 0% | 0 | Common Stock | |
| Franchini Lall Indrani | EVP, CLO & Secretary | Sale of securities on an exchange or to another person at price $ 154.54 per share. | 27 Feb 2024 | 142 | 4,320 (0%) | 0% | 154.5 | 21,945 | Common Stock |
| Poulton V. Jeffrey | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 154.54 per share. | 27 Feb 2024 | 247 | 19,805 (0%) | 0% | 154.5 | 38,171 | Common Stock |
| Garg Pushkal P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 156.38 per share. | 27 Feb 2024 | 115 | 8,684 (0%) | 0% | 156.4 | 17,984 | Common Stock |
| L Greenstreet Yvonne | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 158.12 per share. | 27 Feb 2024 | 8 | 48,128 (0%) | 0% | 158.1 | 1,265 | Common Stock |
| Poulton V. Jeffrey | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 155.45 per share. | 27 Feb 2024 | 194 | 19,611 (0%) | 0% | 155.4 | 30,157 | Common Stock |
| V. Jeffrey Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 158.00 per share. | 27 Feb 2024 | 1 | 19,478 (0%) | 0% | 158 | 158 | Common Stock |
| L Greenstreet Yvonne | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 154.54 per share. | 27 Feb 2024 | 1,259 | 49,801 (0%) | 0% | 154.5 | 194,566 | Common Stock |
| Garg Pushkal P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 157.29 per share. | 27 Feb 2024 | 17 | 8,667 (0%) | 0% | 157.3 | 2,674 | Common Stock |
| Lall Indrani Franchini | EVP, CLO & Secretary | Sale of securities on an exchange or to another person at price $ 155.45 per share. | 27 Feb 2024 | 111 | 4,209 (0%) | 0% | 155.5 | 17,255 | Common Stock |
| Garg Pushkal P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 158.00 per share. | 27 Feb 2024 | 1 | 8,666 (0%) | 0% | 158 | 158 | Common Stock |
| Tanguler Tolga | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 157.29 per share. | 27 Feb 2024 | 14 | 5,237 (0%) | 0% | 157.3 | 2,202 | Common Stock |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 1,908 | 20,052 (0%) | 0% | 0 | Common Stock | |
| Indrani Franchini Lall | EVP, CLO & Secretary | Sale of securities on an exchange or to another person at price $ 157.33 per share. | 27 Feb 2024 | 9 | 4,134 (0%) | 0% | 157.3 | 1,416 | Common Stock |
| Tanguler Tolga | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 155.45 per share. | 27 Feb 2024 | 170 | 5,351 (0%) | 0% | 155.5 | 26,427 | Common Stock |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 155.45 per share. | 27 Feb 2024 | 194 | 8,799 (0%) | 0% | 155.4 | 30,157 | Common Stock |
| V. Jeffrey Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 157.29 per share. | 27 Feb 2024 | 17 | 19,479 (0%) | 0% | 157.3 | 2,674 | Common Stock |
| V. Poulton Jeffrey | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 156.38 per share. | 27 Feb 2024 | 115 | 19,496 (0%) | 0% | 156.4 | 17,984 | Common Stock |
| Tanguler Tolga | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 156.38 per share. | 27 Feb 2024 | 100 | 5,251 (0%) | 0% | 156.4 | 15,638 | Common Stock |
| Garg Pushkal P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 154.54 per share. | 27 Feb 2024 | 247 | 8,993 (0%) | 0% | 154.5 | 38,171 | Common Stock |
| L Yvonne Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 156.38 per share. | 27 Feb 2024 | 588 | 48,220 (0%) | 0% | 156.4 | 91,951 | Common Stock |
| Tanguler Tolga | EVP, Chief Commercial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Feb 2024 | 1,667 | 3,333 | - | - | Restricted Stock Units | |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 147.50 per share. | 15 Feb 2024 | 369 | 4,710 (0%) | 0% | 147.5 | 54,428 | Common Stock |
| Poulton Jeffrey V. | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2024 | 3,278 | 19,151 (0%) | 0% | 0 | Common Stock | |
| L Yvonne Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 147.50 per share. | 15 Feb 2024 | 2,576 | 49,593 (0%) | 0% | 147.5 | 379,960 | Common Stock |
| Greenstreet L Yvonne | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 148.24 per share. | 15 Feb 2024 | 3,614 | 45,979 (0%) | 0% | 148.2 | 535,739 | Common Stock |
| Yvonne Greenstreet L | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2024 | 16,953 | 52,169 (0%) | 0% | 0 | Common Stock | |
| Tolga Tanguler | EVP, Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2024 | 3,278 | 5,079 (0%) | 0% | 0 | Common Stock | |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 149.03 per share. | 15 Feb 2024 | 121 | 4,070 (0%) | 0% | 149.0 | 18,033 | Common Stock |
| V. Poulton Jeffrey | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 147.50 per share. | 15 Feb 2024 | 369 | 18,782 (0%) | 0% | 147.5 | 54,428 | Common Stock |
| Tolga Tanguler | EVP, Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 148.24 per share. | 15 Feb 2024 | 519 | 4,191 (0%) | 0% | 148.2 | 76,937 | Common Stock |
| V. Jeffrey Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 148.24 per share. | 15 Feb 2024 | 518 | 18,264 (0%) | 0% | 148.2 | 76,788 | Common Stock |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Feb 2024 | 4,295 | 8,640 (0%) | 0% | 0 | Common Stock | |
| V. Jeffrey Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 149.03 per share. | 15 Feb 2024 | 120 | 18,144 (0%) | 0% | 149.0 | 17,884 | Common Stock |
| Yvonne Greenstreet L | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 149.03 per share. | 15 Feb 2024 | 840 | 45,139 (0%) | 0% | 149.0 | 125,185 | Common Stock |
| Garg Pushkal P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 148.24 per share. | 15 Feb 2024 | 672 | 7,488 (0%) | 0% | 148.2 | 99,617 | Common Stock |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 149.03 per share. | 15 Feb 2024 | 156 | 7,332 (0%) | 0% | 149.0 | 23,249 | Common Stock |
| Pushkal Garg P. | CMO & EVP Dev & Med Affairs | Sale of securities on an exchange or to another person at price $ 147.50 per share. | 15 Feb 2024 | 480 | 8,160 (0%) | 0% | 147.5 | 70,800 | Common Stock |
| Franchini Indrani Lall | EVP, CLO & Secretary | Sale of securities on an exchange or to another person at price $ 172.38 per share. | 01 Feb 2024 | 269 | 3,584 (0%) | 0% | 172.4 | 46,370 | Common Stock |
| Franchini Indrani Lall | EVP, CLO & Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2024 | 5,175 | 5,175 | - | - | Restricted Stock Units | |
| Indrani Lall Franchini | EVP, CLO & Secretary | Sale of securities on an exchange or to another person at price $ 171.14 per share. | 01 Feb 2024 | 820 | 3,853 (0%) | 0% | 171.1 | 140,335 | Common Stock |
| Indrani Franchini Lall | EVP, CLO & Secretary | Sale of securities on an exchange or to another person at price $ 170.01 per share. | 01 Feb 2024 | 502 | 4,673 (0%) | 0% | 170.0 | 85,345 | Common Stock |
| Indrani Lall Franchini | EVP, CLO & Secretary | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2024 | 5,175 | 5,175 (0%) | 0% | 0 | Common Stock | |
| W. Bonney Michael | Director | Sale of securities on an exchange or to another person at price $ 195.00 per share. | 27 Dec 2023 | 30,000 | 16,029 (0%) | 0% | 195 | 5,850,000 | Common Stock |
| Bonney W. Michael | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 96.45 per share. | 27 Dec 2023 | 30,000 | 46,029 (0%) | 0% | 96.5 | 2,893,500 | Common Stock |
| W. Bonney Michael | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2023 | 30,000 | 0 | - | - | Stock Option (right to buy) | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 186.39 per share. | 03 Aug 2023 | 1,107 | 35,526 (0%) | 0% | 186.4 | 206,334 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 185.54 per share. | 03 Aug 2023 | 1,869 | 36,633 (0%) | 0% | 185.5 | 346,774 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 184.70 per share. | 03 Aug 2023 | 771 | 38,502 (0%) | 0% | 184.7 | 142,404 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Aug 2023 | 3,859 | 39,273 (0%) | 0% | 0 | Common Stock | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Aug 2023 | 5,082 | 35,414 (0%) | 0% | 0 | Common Stock | |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 189.31 per share. | 03 Aug 2023 | 192 | 35,216 (0%) | 0% | 189.3 | 36,348 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 188.41 per share. | 03 Aug 2023 | 17 | 35,408 (0%) | 0% | 188.4 | 3,203 | Common Stock |
| Yvonne L Greenstreet | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 187.37 per share. | 03 Aug 2023 | 101 | 35,425 (0%) | 0% | 187.4 | 18,924 | Common Stock |
| Akshay K. Vaishnaw | President | 03 Aug 2023 | 101 | 22,983 (0%) | 0% | 187.4 | 18,924 | Common Stock | |
| Akshay K. Vaishnaw | President | 03 Aug 2023 | 1,869 | 24,191 (0%) | 0% | 185.5 | 346,774 | Common Stock | |
| Akshay K. Vaishnaw | President | 03 Aug 2023 | 771 | 26,060 (0%) | 0% | 184.7 | 142,404 | Common Stock | |
| Akshay K. Vaishnaw | President | 03 Aug 2023 | 3,859 | 26,831 (0%) | 0% | 0 | Common Stock | ||
| Akshay K. Vaishnaw | President | 03 Aug 2023 | 5,082 | 22,972 (0%) | 0% | 0 | Common Stock | ||
| Akshay K. Vaishnaw | President | 03 Aug 2023 | 192 | 22,774 (0%) | 0% | 189.3 | 36,348 | Common Stock | |
| Akshay K. Vaishnaw | President | 03 Aug 2023 | 17 | 22,966 (0%) | 0% | 188.4 | 3,203 | Common Stock | |
| Akshay K. Vaishnaw | President | 03 Aug 2023 | 1,107 | 23,084 (0%) | 0% | 186.4 | 206,334 | Common Stock | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 186.39 per share. | 03 Aug 2023 | 944 | 16,138 (0%) | 0% | 186.4 | 175,952 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 185.54 per share. | 03 Aug 2023 | 1,593 | 17,082 (0%) | 0% | 185.5 | 295,565 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 184.70 per share. | 03 Aug 2023 | 658 | 18,675 (0%) | 0% | 184.7 | 121,533 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Aug 2023 | 3,109 | 19,333 (0%) | 0% | 0 | Common Stock | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Aug 2023 | 4,518 | 16,224 (0%) | 0% | 0 | Common Stock | |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 189.31 per share. | 03 Aug 2023 | 164 | 15,873 (0%) | 0% | 189.3 | 31,047 | Common Stock |
| Jeffrey V. Poulton | EVP, Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 188.40 per share. | 03 Aug 2023 | 15 | 16,037 (0%) | 0% | 188.4 | 2,826 | Common Stock |