1.2M XNAS Volume
XNAS 19 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.26 per share. | 06 Mar 2025 | 31,370 | 738,104 (1%) | 0% | 0.3 | 8,156 | Common Stock |
| H. Baird Radford | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.26 per share. | 05 Mar 2025 | 14,161 | 163,426 (0%) | 0% | 0.3 | 3,682 | Common Stock |
| Adam Tomasi | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.26 per share. | 05 Mar 2025 | 20,017 | 512,630 (1%) | 0% | 0.3 | 5,204 | Common Stock |
| H. Baird Radford | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.10 per share. | 06 Dec 2024 | 13,138 | 177,587 (0%) | 0% | 1.1 | 14,452 | Common Stock |
| Adam Tomasi | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.10 per share. | 06 Dec 2024 | 21,116 | 532,647 (1%) | 0% | 1.1 | 23,228 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.10 per share. | 05 Dec 2024 | 32,466 | 769,474 (1%) | 0% | 1.1 | 35,713 | Common Stock |
| Chin Lee | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.13 per share. | 04 Dec 2024 | 10,634 | 275,046 (0%) | 0% | 1.1 | 12,016 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.58 per share. | 11 Sep 2024 | 37,311 | 801,940 (1%) | 0% | 0.6 | 21,640 | Common Stock |
| Chin Lee | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.65 per share. | 09 Sep 2024 | 45,320 | 285,680 (0%) | 0% | 0.7 | 29,458 | Common Stock |
| H. Baird Radford | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.65 per share. | 06 Sep 2024 | 13,665 | 190,725 (0%) | 0% | 0.6 | 8,882 | Common Stock |
| Adam Tomasi | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.65 per share. | 06 Sep 2024 | 21,961 | 553,763 (1%) | 0% | 0.7 | 14,275 | Common Stock |
| H. Baird Radford | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 1.01 per share. | 28 Jun 2024 | 87,064 | 204,390 (0%) | 0% | 1.0 | 87,935 | Common Stock |
| Adam Tomasi | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.12 per share. | 07 Jun 2024 | 24,749 | 572,724 (1%) | 0% | 1.1 | 27,719 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.14 per share. | 06 Jun 2024 | 37,525 | 836,251 (1%) | 0% | 1.1 | 42,779 | Common Stock |
| H. Baird Radford | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.19 per share. | 04 Jun 2024 | 14,565 | 291,454 (0%) | 0% | 1.2 | 17,332 | Common Stock |
| Robert E. Andreatta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2024 | 41,000 | 41,000 | - | - | Stock Option (Right to buy) | |
| Steven P. James | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2024 | 41,000 | 41,000 | - | - | Stock Option (Right to buy) | |
| Dolca Thomas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2024 | 41,000 | 41,000 | - | - | Stock Option (Right to buy) | |
| Amy L. Ladd | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2024 | 41,000 | 41,000 | - | - | Stock Option (Right to buy) | |
| Neil Graham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2024 | 41,000 | 41,000 | - | - | Stock Option (Right to buy) | |
| Paul Walker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2024 | 41,000 | 41,000 | - | - | Stock Option (Right to buy) | |
| H. Baird Radford | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.35 per share. | 06 Mar 2024 | 32,142 | 306,019 (0%) | 0% | 1.4 | 43,392 | Common Stock |
| Adam Tomasi | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.44 per share. | 05 Mar 2024 | 47,392 | 597,473 (1%) | 0% | 1.4 | 68,244 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 1.48 per share. | 04 Mar 2024 | 70,910 | 873,776 (1%) | 0% | 1.5 | 104,947 | Common Stock |
| Alexander Robert | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2024 | 2,000,000 | 2,000,000 | - | - | Stock Option (Right to buy) | |
| Tomasi Adam | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2024 | 1,200,000 | 1,200,000 | - | - | Stock Option (Right to buy) | |
| Lee Chin | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2024 | 500,000 | 500,000 | - | - | Stock Option (Right to buy) | |
| H. Radford Baird | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2024 | 900,000 | 900,000 | - | - | Stock Option (Right to buy) | |
| Alexander Robert | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.50 per share. | 04 Dec 2023 | 24,753 | 941,686 (1%) | 0% | 2.5 | 61,883 | Common Stock |
| Adam Tomasi | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.50 per share. | 04 Dec 2023 | 16,054 | 641,865 (1%) | 0% | 2.5 | 40,135 | Common Stock |
| Craig Paterson | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.50 per share. | 04 Dec 2023 | 6,992 | 323,472 (0%) | 0% | 2.5 | 17,480 | Common Stock |
| Baird H. Radford | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.50 per share. | 04 Dec 2023 | 8,380 | 338,161 (0%) | 0% | 2.5 | 20,950 | Common Stock |
| Neil Graham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Aug 2023 | 154,786 | 154,786 | - | - | Stock Option (Right to buy) | |
| Dolca Thomas | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2023 | 154,786 | 154,786 | - | - | Stock Option (Right to buy) | |
| Everett Rand Sutherland | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Aug 2023 | 154,786 | 154,786 | - | - | Stock Option (Right to buy) | |
| H. Baird Radford | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.13 per share. | 02 Jun 2023 | 8,942 | 356,052 (0%) | 0% | 5.1 | 45,872 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.13 per share. | 02 Jun 2023 | 26,415 | 957,862 (1%) | 0% | 5.1 | 135,509 | Common Stock |
| Adam Tomasi | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.13 per share. | 02 Jun 2023 | 17,129 | 673,138 (1%) | 0% | 5.1 | 87,872 | Common Stock |
| Craig Paterson | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.13 per share. | 02 Jun 2023 | 7,460 | 338,399 (0%) | 0% | 5.1 | 38,270 | Common Stock |
| Daniel S. Janney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 86,762 | 86,762 | - | - | Stock Option (Right to buy) | |
| Robert E. Andreatta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 86,762 | 86,762 | - | - | Stock Option (Right to buy) | |
| Steven P. James | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 86,762 | 86,762 | - | - | Stock Option (Right to buy) | |
| Paul Walker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 86,762 | 86,762 | - | - | Stock Option (Right to buy) | |
| Amy L. Ladd | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2023 | 86,762 | 86,762 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.24 per share. | 07 Mar 2023 | 66,274 | 984,277 (2%) | 0% | 6.2 | 413,550 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.40 per share. | 07 Mar 2023 | 9,143 | 1,050,551 (2%) | 0% | 6.4 | 58,515 | Common Stock |
| Adam Tomasi | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.34 per share. | 06 Mar 2023 | 57,467 | 690,267 (1%) | 0% | 5.3 | 306,874 | Common Stock |
| H. Baird Radford | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.75 per share. | 03 Mar 2023 | 33,907 | 364,994 (0%) | 0% | 5.7 | 194,965 | Common Stock |
| Craig Paterson | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.83 per share. | 02 Mar 2023 | 26,615 | 345,859 (0%) | 0% | 5.8 | 155,165 | Common Stock |
| H. Baird Radford | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2023 | 126,640 | 398,901 (0%) | 0% | 0 | Common Stock | |
| H. Baird Radford | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2023 | 194,144 | 194,144 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2023 | 462,325 | 462,325 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2023 | 301,575 | 1,056,694 (2%) | 0% | 0 | Common Stock | |
| Adam Tomasi | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2023 | 195,997 | 744,734 (1%) | 0% | 0 | Common Stock | |
| Adam Tomasi | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2023 | 300,471 | 300,471 | - | - | Stock Option (Right to buy) | |
| Craig Paterson | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2023 | 157,428 | 157,428 | - | - | Stock Option (Right to buy) | |
| Craig Paterson | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jan 2023 | 102,690 | 372,474 (0%) | 0% | 0 | Common Stock | |
| H. Baird Radford | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.11 per share. | 02 Dec 2022 | 3,843 | 272,261 (0%) | 0% | 8.1 | 31,167 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.11 per share. | 02 Dec 2022 | 15,152 | 755,119 (1%) | 0% | 8.1 | 122,883 | Common Stock |
| Adam Tomasi | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.11 per share. | 02 Dec 2022 | 9,783 | 548,737 (1%) | 0% | 8.1 | 79,340 | Common Stock |
| Craig Paterson | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.11 per share. | 02 Dec 2022 | 4,863 | 269,784 (0%) | 0% | 8.1 | 39,439 | Common Stock |
| Daniel S. Janney | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 5.02 per share. | 21 Sep 2022 | 475,000 | 2,546,147 (5%) | 0% | 5.0 | 2,384,500 | Common Stock |
| Paul Walker | Director | Purchase of securities on an exchange or from another person at price $ 5.02 per share. | 21 Sep 2022 | 3,386,400 | 3,386,400 (6%) | 6% | 5.0 | 16,999,728 | Common Stock |
| Paul Walker | Director | Purchase of securities on an exchange or from another person at price $ 5.02 per share. | 21 Sep 2022 | 597,600 | 2,760,860 (5%) | 1% | 5.0 | 2,999,952 | Common Stock |
| H. Baird Radford | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.54 per share. | 02 Sep 2022 | 585 | 276,104 (0%) | 0% | 4.5 | 2,656 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.54 per share. | 02 Sep 2022 | 8,316 | 770,271 (1%) | 0% | 4.5 | 37,755 | Common Stock |
| Adam Tomasi | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.54 per share. | 02 Sep 2022 | 5,369 | 558,520 (1%) | 0% | 4.5 | 24,375 | Common Stock |
| Craig Paterson | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.54 per share. | 02 Sep 2022 | 1,129 | 274,647 (0%) | 0% | 4.5 | 5,126 | Common Stock |
| Margaret Nell Fitzgerald | General Counsel and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.54 per share. | 02 Sep 2022 | 335 | 153,128 (0%) | 0% | 4.5 | 1,521 | Common Stock |
| Amy L. Ladd | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jul 2022 | 233,177 | 233,177 | - | - | Stock Option (Right to buy) | |
| H. Baird Radford | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.75 per share. | 02 Jun 2022 | 2,274 | 276,689 (0%) | 0% | 2.8 | 6,254 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.75 per share. | 02 Jun 2022 | 8,084 | 778,587 (1%) | 0% | 2.8 | 22,231 | Common Stock |
| Adam Tomasi | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.75 per share. | 02 Jun 2022 | 5,219 | 563,889 (1%) | 0% | 2.7 | 14,352 | Common Stock |
| Craig Paterson | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.75 per share. | 02 Jun 2022 | 226 | 275,776 (0%) | 0% | 2.8 | 622 | Common Stock |
| Margaret Nell Fitzgerald | General Counsel and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 2.75 per share. | 02 Jun 2022 | 318 | 150,463 (0%) | 0% | 2.8 | 875 | Common Stock |
| Daniel S. Janney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2022 | 99,590 | 99,590 | - | - | Stock Option (Right to buy) | |
| John P. Mckearn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2022 | 99,590 | 99,590 | - | - | Stock Option (Right to buy) | |
| Robert E. Andreatta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2022 | 99,590 | 99,590 | - | - | Stock Option (Right to buy) | |
| Steven P. James | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2022 | 99,590 | 99,590 | - | - | Stock Option (Right to buy) | |
| Paul Walker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2022 | 99,590 | 99,590 | - | - | Stock Option (Right to Buy) | |
| Margaret Nell Fitzgerald | General Counsel and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Apr 2022 | 57,637 | 150,781 (0%) | 0% | 0 | Common Stock | |
| Mark Asbury | CLO, GC and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.38 per share. | 02 Mar 2022 | 1,680 | 226,935 (0%) | 0% | 5.4 | 9,038 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.38 per share. | 02 Mar 2022 | 8,215 | 786,671 (1%) | 0% | 5.4 | 44,197 | Common Stock |
| Adam Tomasi | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.38 per share. | 02 Mar 2022 | 5,582 | 569,108 (1%) | 0% | 5.4 | 30,031 | Common Stock |
| H. Baird Radford | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 237,608 | 278,963 (0%) | 0% | 0 | Common Stock | |
| Mark Asbury | CLO, GC and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 140,490 | 228,615 (0%) | 0% | 0 | Common Stock | |
| Robert Alexander | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 529,323 | 794,886 (1%) | 1% | 0 | Common Stock | |
| Adam Tomasi | President and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Feb 2022 | 344,060 | 574,690 (1%) | 0% | 0 | Common Stock | |
| Steven P. James | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.52 per share. | 28 Sep 2021 | 4,000 | 4,000 (0%) | 0% | 0.5 | 2,100 | Common Stock |
| Steven P. James | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Sep 2021 | 4,000 | 55,380 | - | - | Stock Option (Right to buy) | |
| Steven P. James | Director | Sale of securities on an exchange or to another person at price $ 108.12 per share. | 28 Sep 2021 | 4,000 | 0 (0%) | 0% | 108.1 | 432,480 | Common Stock |
| Mark Asbury | CLO, GC and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 91.66 per share. | 02 Sep 2021 | 698 | 61,810 (0%) | 0% | 91.7 | 63,979 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 91.66 per share. | 02 Sep 2021 | 3,985 | 233,810 (0%) | 0% | 91.7 | 365,265 | Common Stock |
| Adam Tomasi | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 91.66 per share. | 02 Sep 2021 | 2,346 | 210,022 (0%) | 0% | 91.7 | 215,034 | Common Stock |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.31 per share. | 31 Aug 2021 | 64,148 | 212,368 (0%) | 0% | 4.3 | 276,638 | Common Stock |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Aug 2021 | 64,148 | 88,036 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 14 Jun 2021 | 20,000 | 168,220 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Adam Tomasi | President and COO | Sale of securities on an exchange or to another person at price $ 91.62 per share. | 14 Jun 2021 | 20,000 | 148,220 (0%) | 0% | 91.6 | 1,832,362 | Common Stock |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 14 Jun 2021 | 20,000 | 168,220 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Adam Tomasi | President and COO | Sale of securities on an exchange or to another person at price $ 91.03 per share. | 14 Jun 2021 | 20,000 | 148,220 (0%) | 0% | 91.0 | 1,820,502 | Common Stock |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2021 | 20,000 | 506,400 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2021 | 20,000 | 486,400 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President and COO | Sale of securities on an exchange or to another person at price $ 90.26 per share. | 03 Jun 2021 | 642 | 150,707 (0%) | 0% | 90.3 | 57,947 | Common Stock |
| Adam Tomasi | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 92.20 per share. | 03 Jun 2021 | 1,777 | 151,349 (0%) | 0% | 92.2 | 163,839 | Common Stock |
| Adam Tomasi | President and COO | Sale of securities on an exchange or to another person at price $ 92.03 per share. | 03 Jun 2021 | 2,487 | 148,220 (0%) | 0% | 92.0 | 228,879 | Common Stock |
| Daniel S. Janney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 7,700 | 7,700 | - | - | Stock Option (Right to buy) | |
| John P. Mckearn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 7,700 | 7,700 | - | - | Stock Option (Right to buy) | |
| Robert E. Andreatta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 7,700 | 7,700 | - | - | Stock Option (Right to buy) | |
| Steven P. James | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 7,700 | 7,700 | - | - | Stock Option (Right to buy) | |
| Paul Walker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 7,700 | 7,700 | - | - | Stock Option (Right to buy) | |
| Natalie C. Holles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 May 2021 | 7,700 | 7,700 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 102.32 per share. | 17 May 2021 | 14,517 | 245,395 (0%) | 0% | 102.3 | 1,485,379 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2021 | 14,517 | 985,083 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2021 | 14,517 | 970,566 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 May 2021 | 14,516 | 956,050 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 99.69 per share. | 17 May 2021 | 5,484 | 347,716 (0%) | 0% | 99.7 | 546,700 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 102.29 per share. | 17 May 2021 | 5,484 | 342,232 (0%) | 0% | 102.3 | 560,958 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 98.89 per share. | 17 May 2021 | 5,482 | 336,750 (0%) | 0% | 98.9 | 542,115 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 17 May 2021 | 14,517 | 259,912 (0%) | 0% | 0.7 | 9,980 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 99.68 per share. | 17 May 2021 | 14,517 | 245,395 (0%) | 0% | 99.7 | 1,447,055 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 17 May 2021 | 14,517 | 259,912 (0%) | 0% | 0.7 | 9,980 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 17 May 2021 | 14,516 | 259,911 (0%) | 0% | 0.7 | 9,980 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 98.94 per share. | 17 May 2021 | 14,516 | 245,395 (0%) | 0% | 98.9 | 1,436,213 | Common Stock |
| Adam Tomasi | President and COO | Sale of securities on an exchange or to another person at price $ 99.23 per share. | 10 May 2021 | 20,000 | 153,126 (0%) | 0% | 99.2 | 1,984,600 | Common Stock |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2021 | 20,000 | 566,400 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2021 | 20,000 | 546,400 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2021 | 20,000 | 526,400 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 10 May 2021 | 20,000 | 173,126 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Adam Tomasi | President and COO | Sale of securities on an exchange or to another person at price $ 96.02 per share. | 10 May 2021 | 20,000 | 153,126 (0%) | 0% | 96.0 | 1,920,400 | Common Stock |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 10 May 2021 | 20,000 | 173,126 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Adam Tomasi | President and COO | Sale of securities on an exchange or to another person at price $ 97.79 per share. | 10 May 2021 | 20,000 | 153,126 (0%) | 0% | 97.8 | 1,955,800 | Common Stock |
| Adam Tomasi | President and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 10 May 2021 | 20,000 | 173,126 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| H. Baird Radford | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Apr 2021 | 27,600 | 27,600 | - | - | Stock Option (Right to buy) | |
| H. Baird Radford | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Apr 2021 | 17,100 | 17,100 (0%) | 0% | 0 | Common Stock | |
| Adam Tomasi | President, COO and CFO | Sale of securities on an exchange or to another person at price $ 107.77 per share. | 12 Apr 2021 | 20,000 | 153,126 (0%) | 0% | 107.8 | 2,155,400 | Common Stock |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Apr 2021 | 20,000 | 626,400 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Apr 2021 | 20,000 | 606,400 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Apr 2021 | 20,000 | 586,400 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 12 Apr 2021 | 20,000 | 173,126 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Adam Tomasi | President, COO and CFO | Sale of securities on an exchange or to another person at price $ 104.40 per share. | 12 Apr 2021 | 20,000 | 153,126 (0%) | 0% | 104.4 | 2,088,000 | Common Stock |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 12 Apr 2021 | 20,000 | 173,126 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Adam Tomasi | President, COO and CFO | Sale of securities on an exchange or to another person at price $ 103.08 per share. | 12 Apr 2021 | 20,000 | 153,126 (0%) | 0% | 103.1 | 2,061,600 | Common Stock |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 12 Apr 2021 | 20,000 | 173,126 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2021 | 10,000 | 282,000 | - | - | Stock Option (Right to buy) | |
| Henrik S. Rasmussen | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 111.68 per share. | 01 Apr 2021 | 10,000 | 101,819 (0%) | 0% | 111.7 | 1,116,800 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 01 Apr 2021 | 10,000 | 111,819 (0%) | 0% | 1.2 | 11,625 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 113.06 per share. | 01 Apr 2021 | 20,000 | 101,819 (0%) | 0% | 113.1 | 2,261,200 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 01 Apr 2021 | 20,000 | 121,819 (0%) | 0% | 1.2 | 23,250 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 114.40 per share. | 01 Apr 2021 | 20,000 | 101,819 (0%) | 0% | 114.4 | 2,288,000 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 01 Apr 2021 | 20,000 | 121,819 (0%) | 0% | 1.2 | 23,250 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2021 | 20,000 | 292,000 | - | - | Stock Option (Right to buy) | |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2021 | 20,000 | 312,000 | - | - | Stock Option (Right to buy) | |
| Daniel S. Janney | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 116.09 per share. | 26 Mar 2021 | 2,500 | 56,293 (0%) | 0% | 116.1 | 290,225 | Common Stock |
| Daniel S. Janney | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 115.01 per share. | 26 Mar 2021 | 14,808 | 58,793 (0%) | 0% | 115.0 | 1,703,068 | Common Stock |
| John P. Mckearn | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 26 Mar 2021 | 1,200 | 0 (0%) | 0% | 0 | Common Stock | |
| John P. Mckearn | Director | Sale of securities on an exchange or to another person at price $ 115.00 per share. | 26 Mar 2021 | 7,439 | 1,200 (0%) | 0% | 115 | 855,485 | Common Stock |
| Daniel S. Janney | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 119.46 per share. | 22 Mar 2021 | 9,030 | 77,719 (0%) | 0% | 119.5 | 1,078,724 | Common Stock |
| Daniel S. Janney | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 120.22 per share. | 22 Mar 2021 | 4,118 | 73,601 (0%) | 0% | 120.2 | 495,066 | Common Stock |
| Steven P. James | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.53 per share. | 16 Mar 2021 | 3,500 | 3,500 (0%) | 0% | 0.5 | 1,838 | Common Stock |
| Steven P. James | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2021 | 3,500 | 59,380 | - | - | Stock Option (Right to buy) | |
| Steven P. James | Director | Sale of securities on an exchange or to another person at price $ 121.65 per share. | 16 Mar 2021 | 3,500 | 0 (0%) | 0% | 121.7 | 425,775 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 15 Mar 2021 | 20,000 | 265,395 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2021 | 20,000 | 1,039,600 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2021 | 20,000 | 1,019,600 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2021 | 20,000 | 999,600 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 15 Mar 2021 | 20,000 | 265,395 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 122.78 per share. | 15 Mar 2021 | 20,000 | 245,395 (0%) | 0% | 122.8 | 2,455,600 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 15 Mar 2021 | 20,000 | 265,395 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 121.76 per share. | 15 Mar 2021 | 20,000 | 245,395 (0%) | 0% | 121.8 | 2,435,200 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 121.14 per share. | 15 Mar 2021 | 20,000 | 245,395 (0%) | 0% | 121.1 | 2,422,800 | Common Stock |
| Daniel S. Janney | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 124.18 per share. | 12 Mar 2021 | 4,071 | 93,457 (0%) | 0% | 124.2 | 505,537 | Common Stock |
| Daniel S. Janney | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 124.56 per share. | 12 Mar 2021 | 6,708 | 86,749 (0%) | 0% | 124.6 | 835,548 | Common Stock |
| Daniel S. Janney | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 125.00 per share. | 09 Mar 2021 | 100 | 103,534 (0%) | 0% | 125 | 12,500 | Common Stock |
| Daniel S. Janney | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 124.62 per share. | 09 Mar 2021 | 6,006 | 97,528 (0%) | 0% | 124.6 | 748,468 | Common Stock |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 08 Mar 2021 | 20,000 | 173,126 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2021 | 20,000 | 686,400 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2021 | 20,000 | 666,400 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2021 | 20,000 | 646,400 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 08 Mar 2021 | 20,000 | 173,126 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Adam Tomasi | President, COO and CFO | Sale of securities on an exchange or to another person at price $ 122.78 per share. | 08 Mar 2021 | 20,000 | 153,126 (0%) | 0% | 122.8 | 2,455,600 | Common Stock |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.69 per share. | 08 Mar 2021 | 20,000 | 173,126 (0%) | 0% | 0.7 | 13,750 | Common Stock |
| Adam Tomasi | President, COO and CFO | Sale of securities on an exchange or to another person at price $ 121.78 per share. | 08 Mar 2021 | 20,000 | 153,126 (0%) | 0% | 121.8 | 2,435,600 | Common Stock |
| Adam Tomasi | President, COO and CFO | Sale of securities on an exchange or to another person at price $ 121.78 per share. | 08 Mar 2021 | 20,000 | 153,126 (0%) | 0% | 121.8 | 2,435,600 | Common Stock |
| Mark Asbury | CLO, GC and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.82 per share. | 02 Mar 2021 | 733 | 63,242 (0%) | 0% | 117.8 | 86,362 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.82 per share. | 02 Mar 2021 | 3,890 | 245,395 (0%) | 0% | 117.8 | 458,320 | Common Stock |
| Adam Tomasi | President, COO and CFO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.82 per share. | 02 Mar 2021 | 1,717 | 156,315 (0%) | 0% | 117.8 | 202,297 | Common Stock |
| Adam Tomasi | President, COO and CFO | Sale of securities on an exchange or to another person at price $ 113.56 per share. | 02 Mar 2021 | 3,189 | 153,126 (0%) | 0% | 113.6 | 362,143 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 01 Mar 2021 | 20,000 | 125,087 (0%) | 0% | 1.2 | 23,250 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 117.32 per share. | 01 Mar 2021 | 20,000 | 105,087 (0%) | 0% | 117.3 | 2,346,400 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 117.82 per share. | 01 Mar 2021 | 1,316 | 103,771 (0%) | 0% | 117.8 | 155,051 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 01 Mar 2021 | 20,000 | 123,771 (0%) | 0% | 1.2 | 23,250 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 113.00 per share. | 01 Mar 2021 | 20,000 | 103,771 (0%) | 0% | 113 | 2,260,000 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 112.83 per share. | 01 Mar 2021 | 1,952 | 101,819 (0%) | 0% | 112.8 | 220,244 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2021 | 20,000 | 372,000 | - | - | Stock Option (Right to buy) | |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2021 | 20,000 | 352,000 | - | - | Stock Option (Right to buy) | |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2021 | 20,000 | 332,000 | - | - | Stock Option (Right to buy) | |
| Henrik S. Rasmussen | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.16 per share. | 01 Mar 2021 | 20,000 | 125,087 (0%) | 0% | 1.2 | 23,250 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 120.66 per share. | 01 Mar 2021 | 20,000 | 105,087 (0%) | 0% | 120.7 | 2,413,200 | Common Stock |
| John P. Mckearn | Director | Other type of transaction at price $ 0.00 per share. | 18 Feb 2021 | 8,016 | 8,639 (0%) | 0% | 0 | Common Stock | |
| John P. Mckearn | Director | Other type of transaction at price $ 0.00 per share. | 18 Feb 2021 | 47,494 | 4,887,932 (10%) | 0% | 0 | Common Stock | |
| John P. Mckearn | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 04 Jan 2021 | 862,574 | 4,935,426 (10%) | 1% | 0 | Common Stock | |
| John P. Mckearn | Director, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 04 Jan 2021 | 623 | 623 (0%) | 0% | 0 | Common Stock | |
| Natalie C. Holles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2021 | 4,000 | 4,000 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Dec 2020 | 8,240 | 306,960 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.31 per share. | 29 Dec 2020 | 8,240 | 241,105 (0%) | 0% | 4.3 | 35,535 | Common Stock |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Dec 2020 | 5,416 | 152,184 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | President, COO and CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.31 per share. | 29 Dec 2020 | 5,416 | 157,757 (0%) | 0% | 4.3 | 23,357 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 99.04 per share. | 01 Dec 2020 | 3,954 | 104,812 (0%) | 0% | 99.0 | 391,604 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2020 | 52,300 | 108,766 (0%) | 0% | 0 | Common Stock | |
| Mark Asbury | CLO, GC and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2020 | 32,400 | 66,234 (0%) | 0% | 0 | Common Stock | |
| Mark Asbury | CLO, GC and Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 99.04 per share. | 01 Dec 2020 | 2,977 | 63,257 (0%) | 0% | 99.0 | 294,842 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 99.04 per share. | 01 Dec 2020 | 14,501 | 232,865 (0%) | 0% | 99.0 | 1,436,179 | Common Stock |
| Robert Alexander | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2020 | 121,600 | 247,366 (0%) | 0% | 0 | Common Stock | |
| Adam Tomasi | President and COO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 99.04 per share. | 01 Dec 2020 | 8,825 | 152,341 (0%) | 0% | 99.0 | 874,028 | Common Stock |
| Adam Tomasi | President and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2020 | 78,500 | 161,166 (0%) | 0% | 0 | Common Stock | |
| Leo Redmond | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 99.04 per share. | 01 Dec 2020 | 2,472 | 51,958 (0%) | 0% | 99.0 | 244,827 | Common Stock |
| Leo Redmond | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Dec 2020 | 26,900 | 54,430 (0%) | 0% | 0 | Common Stock | |
| Daniel S. Janney | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2020 | 7,700 | 7,700 | - | - | Stock Option (Right to Buy) | |
| John P. Mckearn | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2020 | 7,700 | 7,700 | - | - | Stock Option (Right to Buy) | |
| Robert E. Andreatta | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2020 | 7,700 | 7,700 | - | - | Stock Option (Right to Buy) | |
| Steven P. James | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2020 | 7,700 | 7,700 | - | - | Stock Option (Right to Buy) | |
| Paul Walker | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 May 2020 | 7,700 | 7,700 | - | - | Stock Option (Right to Buy) | |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 71.04 per share. | 12 May 2020 | 1,150,000 | 5,750,506 (11%) | 2% | 71.0 | 81,696,000 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Nov 2019 | 52,300 | 55,077 (0%) | 0% | 0 | Common Stock | |
| Mark Asbury | Other | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Nov 2019 | 32,400 | 33,117 (0%) | 0% | 0 | Common Stock | |
| Robert Alexander | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Nov 2019 | 121,600 | 124,377 (0%) | 0% | 0 | Common Stock | |
| Adam Tomasi | President and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Nov 2019 | 78,500 | 81,277 (0%) | 0% | 0 | Common Stock | |
| Leo Redmond | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Nov 2019 | 26,900 | 26,900 (0%) | 0% | 0 | Common Stock | |
| Leo Redmond | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Aug 2019 | 120,000 | 120,000 | - | - | Stock Option (Right to Buy) | |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 40.58 per share. | 07 Jun 2019 | 7,100 | 6,900,738 (14%) | 0% | 40.6 | 288,118 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 41.05 per share. | 07 Jun 2019 | 232 | 6,900,506 (14%) | 0% | 41.1 | 9,524 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 39.62 per share. | 07 Jun 2019 | 31,400 | 6,907,838 (14%) | 0% | 39.6 | 1,244,068 | Common Stock |
| Daniel S. Janney | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| John P. Mckearn | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Robert E. Andreatta | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Steven P. James | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| Paul Walker | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 16,000 | 16,000 | - | - | Stock Option (Right to Buy) | |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 39.49 per share. | 04 Jun 2019 | 6,248 | 7,004,631 (14%) | 0% | 39.5 | 246,734 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 40.40 per share. | 04 Jun 2019 | 900 | 7,032,073 (14%) | 0% | 40.4 | 36,360 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 39.50 per share. | 04 Jun 2019 | 21,194 | 7,010,879 (14%) | 0% | 39.5 | 837,163 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 39.81 per share. | 04 Jun 2019 | 17,500 | 6,987,131 (14%) | 0% | 39.8 | 696,675 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 40.01 per share. | 04 Jun 2019 | 47,893 | 6,939,238 (14%) | 0% | 40.0 | 1,916,199 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 43.27 per share. | 30 May 2019 | 600 | 7,086,279 (14%) | 0% | 43.3 | 25,962 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 39.63 per share. | 30 May 2019 | 22,049 | 7,035,573 (14%) | 0% | 39.6 | 873,802 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 40.16 per share. | 30 May 2019 | 4,257 | 7,057,622 (14%) | 0% | 40.2 | 170,961 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 38.97 per share. | 30 May 2019 | 2,600 | 7,032,973 (14%) | 0% | 39.0 | 101,322 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 39.12 per share. | 30 May 2019 | 17,321 | 7,061,879 (14%) | 0% | 39.1 | 677,598 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 40.06 per share. | 30 May 2019 | 7,079 | 7,079,200 (14%) | 0% | 40.1 | 283,585 | Common Stock |
| Mark Asbury | Other | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2019 | 39,910 | 39,910 | - | - | Stock Option (Right to Buy) | |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 36.33 per share. | 16 Apr 2019 | 35,889 | 7,110,307 (14%) | 0% | 36.3 | 1,303,847 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 34.82 per share. | 16 Apr 2019 | 1,028 | 7,086,879 (14%) | 0% | 34.8 | 35,795 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 36.07 per share. | 16 Apr 2019 | 2,400 | 7,087,907 (14%) | 0% | 36.1 | 86,568 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 36.33 per share. | 16 Apr 2019 | 20,000 | 7,090,307 (14%) | 0% | 36.3 | 726,600 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 37.23 per share. | 16 Apr 2019 | 22,679 | 7,153,517 (14%) | 0% | 37.2 | 844,339 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 36.80 per share. | 16 Apr 2019 | 7,321 | 7,146,196 (14%) | 0% | 36.8 | 269,413 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 35.03 per share. | 15 Feb 2019 | 9,228 | 7,309,187 (15%) | 0% | 35.0 | 323,257 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 34.34 per share. | 15 Feb 2019 | 92,219 | 7,176,196 (14%) | 0% | 34.3 | 3,166,800 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 34.72 per share. | 15 Feb 2019 | 40,772 | 7,268,415 (14%) | 0% | 34.7 | 1,415,604 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 43.26 per share. | 24 Jan 2019 | 12,955 | 7,278,533 (14%) | 0% | 43.3 | 560,433 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 42.42 per share. | 24 Jan 2019 | 39,882 | 7,318,415 (15%) | 0% | 42.4 | 1,691,794 | Common Stock |
| Henrik S. Rasmussen | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Oct 2018 | 80,000 | 80,000 | - | - | Stock Option (Right to buy) | |
| Robert Alexander | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Oct 2018 | 250,000 | 250,000 | - | - | Stock Option (Right to buy) | |
| Adam Tomasi | COO, CFO and Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Oct 2018 | 125,000 | 125,000 | - | - | Stock Option (Right to buy) | |
| Daniel S. Janney | Director, Ten Percent Owner | 23 Jul 2018 | 11,269,200 | 11,269,200 (27%) | 27% | 0 | Common Stock | ||
| Daniel S. Janney | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 18.00 per share. | 23 Jul 2018 | 250,000 | 11,519,200 (28%) | 0% | 18 | 4,500,000 | Common Stock |
| Daniel S. Janney | Director, Ten Percent Owner | 23 Jul 2018 | 1,239,007 | 0 | - | - | Series B Preferred Stock | ||
| Daniel S. Janney | Director, Ten Percent Owner | 23 Jul 2018 | 10,030,193 | 0 | - | - | Series A Preferred Stock | ||
| John P. Mckearn | Director, Ten Percent Owner | 23 Jul 2018 | 777,417 | 0 | - | - | Series B Preferred Stock | ||
| John P. Mckearn | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 18.00 per share. | 23 Jul 2018 | 111,111 | 7,371,252 (18%) | 0% | 18 | 1,999,998 | Common Stock |
| John P. Mckearn | Director, Ten Percent Owner | 23 Jul 2018 | 7,260,141 | 7,260,141 (17%) | 17% | 0 | Common Stock | ||
| John P. Mckearn | Director, Ten Percent Owner | 23 Jul 2018 | 6,482,724 | 0 | - | - | Series A Preferred Stock |