XNAS 16 Jul, 2025 12:41 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 51.73 per share. | 10 Jul 2025 | 15,314 | 520,757 (1%) | 0% | 51.7 | 792,224 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 50.57 per share. | 10 Jul 2025 | 14,686 | 536,071 (1%) | 0% | 50.6 | 742,671 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2025 | 12,500 | 19,933 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 52.61 per share. | 07 Jul 2025 | 41 | 167,124 (0%) | 0% | 52.6 | 2,157 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 52.00 per share. | 07 Jul 2025 | 1,825 | 167,165 (0%) | 0% | 52.0 | 94,893 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.93 per share. | 07 Jul 2025 | 10,634 | 168,990 (0%) | 0% | 50.9 | 541,611 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.09 per share. | 07 Jul 2025 | 12,500 | 179,624 (0%) | 0% | 21.1 | 263,625 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 52.88 per share. | 01 Jul 2025 | 2,000 | 29,891 (0%) | 0% | 52.9 | 105,760 | Common Stock |
| Scott A. Gangloff | Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 23.87 per share. | 30 Jun 2025 | 299 | 23,751 (0%) | 0% | 23.9 | 7,137 | Common Stock |
| Andrew Cheng | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 23.87 per share. | 30 Jun 2025 | 890 | 550,757 (1%) | 0% | 23.9 | 21,243 | Common Stock |
| Jonathan Young | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 23.87 per share. | 30 Jun 2025 | 890 | 197,484 (0%) | 0% | 23.9 | 21,243 | Common Stock |
| William R. White | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 23.87 per share. | 30 Jun 2025 | 890 | 58,411 (0%) | 0% | 23.9 | 21,243 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 23.87 per share. | 30 Jun 2025 | 890 | 167,124 (0%) | 0% | 23.9 | 21,243 | Common Stock |
| Catriona Yale | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 23.87 per share. | 30 Jun 2025 | 890 | 91,488 (0%) | 0% | 23.9 | 21,243 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Grant, award, or other acquisition of securities at price $ 23.87 per share. | 30 Jun 2025 | 193 | 31,891 (0%) | 0% | 23.9 | 4,607 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 54.59 per share. | 20 Jun 2025 | 875 | 31,698 (0%) | 0% | 54.6 | 47,766 | Common Stock |
| Scott A. Gangloff | Chief Technology Officer | Sale of securities on an exchange or to another person at price $ 54.84 per share. | 18 Jun 2025 | 848 | 23,452 (0%) | 0% | 54.8 | 46,504 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 54.84 per share. | 18 Jun 2025 | 6,620 | 549,867 (1%) | 0% | 54.8 | 363,041 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 54.84 per share. | 18 Jun 2025 | 1,453 | 196,594 (0%) | 0% | 54.8 | 79,683 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 54.84 per share. | 18 Jun 2025 | 1,634 | 57,521 (0%) | 0% | 54.8 | 89,609 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 54.84 per share. | 18 Jun 2025 | 1,129 | 166,234 (0%) | 0% | 54.8 | 61,914 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 54.84 per share. | 18 Jun 2025 | 1,633 | 90,598 (0%) | 0% | 54.8 | 89,554 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 16 Jun 2025 | 10,000 | 102,231 (0%) | 0% | 21.1 | 211,000 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2025 | 10,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 54.80 per share. | 16 Jun 2025 | 2,895 | 93,126 (0%) | 0% | 54.8 | 158,643 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 55.52 per share. | 16 Jun 2025 | 895 | 92,231 (0%) | 0% | 55.5 | 49,690 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 53.78 per share. | 16 Jun 2025 | 6,210 | 96,021 (0%) | 0% | 53.8 | 333,974 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 53.82 per share. | 16 Jun 2025 | 1,500 | 33,073 (0%) | 0% | 53.8 | 80,726 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2025 | 2,000 | 64,182 | - | - | Stock Option (Right to Buy) | |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 55.09 per share. | 16 Jun 2025 | 500 | 32,573 (0%) | 0% | 55.1 | 27,546 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.87 per share. | 16 Jun 2025 | 2,000 | 34,573 (0%) | 0% | 19.9 | 39,740 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 53.76 per share. | 10 Jun 2025 | 14,842 | 579,482 (2%) | 0% | 53.8 | 797,906 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 53.99 per share. | 10 Jun 2025 | 7,837 | 556,487 (1%) | 0% | 54.0 | 423,151 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 54.35 per share. | 10 Jun 2025 | 15,158 | 564,324 (1%) | 0% | 54.4 | 823,883 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 53.99 per share. | 10 Jun 2025 | 2,493 | 198,047 (0%) | 0% | 54.0 | 134,605 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 54.00 per share. | 10 Jun 2025 | 2,804 | 59,155 (0%) | 0% | 54.0 | 151,402 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 54.00 per share. | 10 Jun 2025 | 2,358 | 167,363 (0%) | 0% | 54.0 | 127,323 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 54.00 per share. | 10 Jun 2025 | 2,803 | 92,231 (0%) | 0% | 54.0 | 151,351 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 54.00 per share. | 10 Jun 2025 | 919 | 32,573 (0%) | 0% | 54.0 | 49,625 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 05 Jun 2025 | 12,500 | 182,221 (0%) | 0% | 21.1 | 263,750 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2025 | 24,611 | 32,433 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2025 | 389 | 0 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2025 | 12,500 | 389 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 55.04 per share. | 05 Jun 2025 | 25,000 | 169,721 (0%) | 0% | 55.0 | 1,376,000 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 05 Jun 2025 | 389 | 194,721 (0%) | 0% | 21.1 | 8,208 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.09 per share. | 05 Jun 2025 | 24,611 | 194,332 (0%) | 0% | 21.1 | 519,046 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 53.84 per share. | 05 Jun 2025 | 3,150 | 169,721 (0%) | 0% | 53.8 | 169,596 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 53.37 per share. | 05 Jun 2025 | 9,350 | 172,871 (0%) | 0% | 53.4 | 499,038 | Common Stock |
| Jane Pritchett Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 9,398 | 9,398 (0%) | 0% | 0 | Common Stock | |
| Mark T. Iwicki | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 9,398 | 9,398 (0%) | 0% | 0 | Common Stock | |
| Seth L. Harrison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 9,398 | 145,699 (0%) | 0% | 0 | Common Stock | |
| Graham Walmsley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 9,398 | 11,566 (0%) | 0% | 0 | Common Stock | |
| Tomas J. Heyman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 9,398 | 9,398 (0%) | 0% | 0 | Common Stock | |
| Yuan Xu | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 9,398 | 9,398 (0%) | 0% | 0 | Common Stock | |
| Judy Chou | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2025 | 9,398 | 9,398 (0%) | 0% | 0 | Common Stock | |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 49.40 per share. | 02 Jun 2025 | 600 | 36,892 (0%) | 0% | 49.4 | 29,639 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2025 | 4,000 | 66,182 | - | - | Stock Option (Right to Buy) | |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 51.04 per share. | 02 Jun 2025 | 100 | 33,492 (0%) | 0% | 51.0 | 5,104 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 50.46 per share. | 02 Jun 2025 | 3,300 | 33,592 (0%) | 0% | 50.5 | 166,515 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.87 per share. | 02 Jun 2025 | 4,000 | 37,492 (0%) | 0% | 19.9 | 79,480 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 22 May 2025 | 4,000 | 33,492 (0%) | 0% | 50 | 200,000 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 44.37 per share. | 22 May 2025 | 4,000 | 37,492 (0%) | 0% | 44.4 | 177,480 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 May 2025 | 4,000 | 84,904 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 39.46 per share. | 15 May 2025 | 2,779 | 99,418 (0%) | 0% | 39.5 | 109,659 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2025 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 39.91 per share. | 15 May 2025 | 4,384 | 95,034 (0%) | 0% | 39.9 | 174,948 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 38.20 per share. | 15 May 2025 | 2,837 | 102,197 (0%) | 0% | 38.2 | 108,371 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 15 May 2025 | 10,000 | 105,034 (0%) | 0% | 21.1 | 211,000 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 41.00 per share. | 12 May 2025 | 7,200 | 617,124 (2%) | 0% | 41 | 295,200 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 41.63 per share. | 12 May 2025 | 22,800 | 594,324 (2%) | 0% | 41.6 | 949,255 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 42.76 per share. | 07 May 2025 | 3,299 | 33,492 (0%) | 0% | 42.8 | 141,055 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 May 2025 | 8,000 | 70,182 | - | - | Stock Option (Right to Buy) | |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 42.31 per share. | 07 May 2025 | 4,701 | 36,791 (0%) | 0% | 42.3 | 198,895 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.87 per share. | 07 May 2025 | 8,000 | 41,492 (0%) | 0% | 19.9 | 158,960 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 06 May 2025 | 12,500 | 182,221 (0%) | 0% | 21.1 | 263,750 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 May 2025 | 12,500 | 12,889 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 44.50 per share. | 06 May 2025 | 300 | 169,721 (0%) | 0% | 44.5 | 13,351 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 43.87 per share. | 06 May 2025 | 8,650 | 170,021 (0%) | 0% | 43.9 | 379,476 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 42.26 per share. | 06 May 2025 | 3,550 | 178,671 (0%) | 0% | 42.3 | 150,037 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 24 Apr 2025 | 6,250 | 175,971 (0%) | 0% | 21.1 | 131,875 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Apr 2025 | 2,566 | 26,152 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Apr 2025 | 3,684 | 25,389 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 41.03 per share. | 24 Apr 2025 | 6,250 | 169,721 (0%) | 0% | 41.0 | 256,438 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 9,073 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 38.62 per share. | 15 Apr 2025 | 1,200 | 95,034 (0%) | 0% | 38.6 | 46,339 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 37.80 per share. | 15 Apr 2025 | 7,873 | 96,234 (0%) | 0% | 37.8 | 297,623 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 15 Apr 2025 | 9,073 | 104,107 (0%) | 0% | 21.1 | 191,440 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 35.23 per share. | 10 Apr 2025 | 30,000 | 624,324 (2%) | 0% | 35.2 | 1,056,780 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 07 Apr 2025 | 6,250 | 175,971 (0%) | 0% | 21.1 | 131,875 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Apr 2025 | 6,250 | 28,718 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 37.92 per share. | 07 Apr 2025 | 200 | 169,721 (0%) | 0% | 37.9 | 7,583 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 36.93 per share. | 07 Apr 2025 | 100 | 169,921 (0%) | 0% | 36.9 | 3,693 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 36.05 per share. | 07 Apr 2025 | 3,750 | 170,021 (0%) | 0% | 36.1 | 135,203 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.36 per share. | 07 Apr 2025 | 2,200 | 173,771 (0%) | 0% | 35.4 | 77,783 | Common Stock |
| Graham Walmsley | Director | Purchase of securities on an exchange or from another person at price $ 44.75 per share. | 25 Mar 2025 | 91,309 | 1,091,309 (3%) | 0% | 44.7 | 4,085,804 | Common Stock |
| Graham Walmsley | Director | Purchase of securities on an exchange or from another person at price $ 43.55 per share. | 25 Mar 2025 | 50,000 | 1,200,000 (4%) | 0% | 43.6 | 2,177,700 | Common Stock |
| Graham Walmsley | Director | Purchase of securities on an exchange or from another person at price $ 43.01 per share. | 25 Mar 2025 | 58,691 | 1,150,000 (4%) | 0% | 43.0 | 2,524,417 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 45.05 per share. | 17 Mar 2025 | 1,799 | 95,034 (0%) | 0% | 45.1 | 81,045 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 44.70 per share. | 17 Mar 2025 | 8,201 | 96,833 (0%) | 0% | 44.7 | 366,560 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 17 Mar 2025 | 10,000 | 105,034 (0%) | 0% | 21.1 | 211,000 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Mar 2025 | 10,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 44.88 per share. | 12 Mar 2025 | 1,738 | 654,324 (2%) | 0% | 44.9 | 78,001 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 44.88 per share. | 12 Mar 2025 | 607 | 200,540 (0%) | 0% | 44.9 | 27,242 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 44.88 per share. | 12 Mar 2025 | 676 | 61,959 (0%) | 0% | 44.9 | 30,339 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 44.88 per share. | 12 Mar 2025 | 516 | 169,721 (0%) | 0% | 44.9 | 23,158 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 44.88 per share. | 12 Mar 2025 | 614 | 95,034 (0%) | 0% | 44.9 | 27,556 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 42.31 per share. | 10 Mar 2025 | 1,216 | 656,062 (2%) | 0% | 42.3 | 51,453 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 41.75 per share. | 10 Mar 2025 | 28,784 | 657,278 (2%) | 0% | 41.7 | 1,201,617 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2025 | 12,500 | 34,968 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 05 Mar 2025 | 12,500 | 182,737 (0%) | 0% | 21.1 | 263,750 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 44.40 per share. | 05 Mar 2025 | 9,338 | 173,399 (0%) | 0% | 44.4 | 414,617 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 44.90 per share. | 05 Mar 2025 | 3,162 | 170,237 (0%) | 0% | 44.9 | 141,974 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 44.17 per share. | 04 Mar 2025 | 11,447 | 239,700 (0%) | 0% | 44.2 | 505,591 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 45.07 per share. | 04 Mar 2025 | 38,553 | 201,147 (0%) | 0% | 45.1 | 1,737,622 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.87 per share. | 03 Mar 2025 | 1,000 | 34,492 (0%) | 0% | 19.9 | 19,870 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2025 | 1,000 | 78,182 | - | - | Stock Option (Right to Buy) | |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 48.09 per share. | 03 Mar 2025 | 1,000 | 33,492 (0%) | 0% | 48.1 | 48,090 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 18 Feb 2025 | 10,000 | 105,648 (0%) | 0% | 21.1 | 211,000 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 49.79 per share. | 18 Feb 2025 | 9,100 | 96,548 (0%) | 0% | 49.8 | 453,089 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 50.63 per share. | 18 Feb 2025 | 900 | 95,648 (0%) | 0% | 50.6 | 45,571 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 55.81 per share. | 10 Feb 2025 | 200 | 686,062 (2%) | 0% | 55.8 | 11,162 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 51.75 per share. | 10 Feb 2025 | 12,640 | 703,422 (2%) | 0% | 51.8 | 654,145 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 52.91 per share. | 10 Feb 2025 | 6,439 | 696,983 (2%) | 0% | 52.9 | 340,675 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 53.67 per share. | 10 Feb 2025 | 9,972 | 687,011 (2%) | 0% | 53.7 | 535,157 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 54.55 per share. | 10 Feb 2025 | 749 | 686,262 (2%) | 0% | 54.5 | 40,855 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 05 Feb 2025 | 18,750 | 188,987 (0%) | 0% | 21.1 | 395,625 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Feb 2025 | 18,750 | 47,468 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 56.92 per share. | 05 Feb 2025 | 5,903 | 170,237 (0%) | 0% | 56.9 | 336,022 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 56.32 per share. | 05 Feb 2025 | 12,847 | 176,140 (0%) | 0% | 56.3 | 723,607 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 53.57 per share. | 03 Feb 2025 | 5,100 | 256,047 (0%) | 0% | 53.6 | 273,182 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 54.06 per share. | 03 Feb 2025 | 4,900 | 251,147 (0%) | 0% | 54.1 | 264,879 | Common Stock |
| Graham Walmsley | Director | Purchase of securities on an exchange or from another person at price $ 48.00 per share. | 30 Jan 2025 | 200,000 | 1,000,000 (3%) | 0% | 48 | 9,600,000 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 54.56 per share. | 27 Jan 2025 | 24,242 | 721,820 (2%) | 0% | 54.6 | 1,322,644 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 56.89 per share. | 27 Jan 2025 | 3,377 | 716,062 (2%) | 0% | 56.9 | 192,118 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 55.53 per share. | 27 Jan 2025 | 2,381 | 719,439 (2%) | 0% | 55.5 | 132,217 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 56.97 per share. | 27 Jan 2025 | 12,379 | 170,237 (0%) | 0% | 57.0 | 705,232 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 14,986 | 119,969 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 16,264 | 66,218 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.87 per share. | 27 Jan 2025 | 14,986 | 185,223 (0%) | 0% | 19.9 | 297,772 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 27 Jan 2025 | 16,264 | 201,487 (0%) | 0% | 21.1 | 343,170 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 54.76 per share. | 27 Jan 2025 | 13,812 | 187,675 (0%) | 0% | 54.8 | 756,345 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 55.62 per share. | 27 Jan 2025 | 5,059 | 182,616 (0%) | 0% | 55.6 | 281,382 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 20,928 | 52,785 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 20,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 9,074 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.61 per share. | 27 Jan 2025 | 16,849 | 112,497 (0%) | 0% | 0.6 | 10,362 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 27 Jan 2025 | 15,172 | 127,669 (0%) | 0% | 6.4 | 96,555 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.09 per share. | 27 Jan 2025 | 21,569 | 149,238 (0%) | 0% | 21.1 | 454,890 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 55.16 per share. | 27 Jan 2025 | 17,000 | 132,238 (0%) | 0% | 55.2 | 937,652 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 55.95 per share. | 27 Jan 2025 | 9,250 | 122,988 (0%) | 0% | 55.9 | 517,528 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 57.02 per share. | 27 Jan 2025 | 27,340 | 95,648 (0%) | 0% | 57.0 | 1,559,036 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 16,849 | 0 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 15,172 | 0 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 641 | 0 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 27 Jan 2025 | 49,074 | 144,722 (0%) | 0% | 21.1 | 1,035,461 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 55.15 per share. | 27 Jan 2025 | 25,907 | 118,815 (0%) | 0% | 55.2 | 1,428,823 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 55.95 per share. | 27 Jan 2025 | 14,467 | 104,348 (0%) | 0% | 56.0 | 809,429 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 57.01 per share. | 27 Jan 2025 | 8,700 | 95,648 (0%) | 0% | 57.0 | 495,961 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Jan 2025 | 20,000 | 33,421 | - | - | Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jan 2025 | 43,064 | 0 | - | - | Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 24 Jan 2025 | 43,064 | 261,147 (0%) | 0% | 6.4 | 274,059 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jan 2025 | 50,000 | 52,212 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 23 Jan 2025 | 50,000 | 746,062 (2%) | 0% | 0.6 | 30,750 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 28.03 per share. | 02 Jan 2025 | 10,000 | 218,083 (0%) | 0% | 28.0 | 280,330 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.87 per share. | 31 Dec 2024 | 4,000 | 38,492 (0%) | 0% | 19.9 | 79,480 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Dec 2024 | 4,000 | 79,182 | - | - | Stock Option (Right to Buy) | |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 57.03 per share. | 31 Dec 2024 | 5,000 | 33,492 (0%) | 0% | 57.0 | 285,150 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Grant, award, or other acquisition of securities at price $ 19.69 per share. | 31 Dec 2024 | 234 | 34,492 (0%) | 0% | 19.7 | 4,607 | Common Stock |
| Rolph Timothy | Chief Scientific Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 26 Dec 2024 | 14,100 | 184,237 (0%) | 0% | 0 | Common Stock | |
| R. William White | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 24,300 | 62,635 (0%) | 0% | 0 | Common Stock | |
| Young Jonathan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 73,700 | 73,700 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 31.10 per share. | 16 Dec 2024 | 3,800 | 178,337 (0%) | 0% | 31.1 | 118,172 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 29.13 per share. | 16 Dec 2024 | 1,000 | 34,258 (0%) | 0% | 29.1 | 29,130 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 16 Dec 2024 | 9,074 | 104,722 (0%) | 0% | 21.1 | 191,461 | Common Stock |
| Yale Catriona | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 24,300 | 95,648 (0%) | 0% | 0 | Common Stock | |
| Patrick Lamy | Senior VP, Commercial Strategy | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 52,100 | 52,100 | - | - | Stock Option (Right to Buy) | |
| Lamy Patrick | Senior VP, Commercial Strategy | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 17,400 | 35,258 (0%) | 0% | 0 | Common Stock | |
| Jonathan Young | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 24,300 | 228,083 (0%) | 0% | 0 | Common Stock | |
| Rolph Timothy | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 60,000 | 60,000 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2024 | 9,074 | 20,000 | - | - | Stock Option (Right to Buy) | |
| William White R. | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 73,700 | 73,700 | - | - | Stock Option (Right to Buy) | |
| Cheng Andrew | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 295,600 | 295,600 | - | - | Stock Option (Right to Buy) | |
| Yale Catriona | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 73,700 | 73,700 | - | - | Stock Option (Right to Buy) | |
| Cheng Andrew | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 98,500 | 696,062 (2%) | 0% | 0 | Common Stock | |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.87 per share. | 16 Dec 2024 | 3,800 | 182,137 (0%) | 0% | 19.9 | 75,506 | Common Stock |
| Rolph Timothy | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2024 | 3,800 | 134,955 | - | - | Stock Option (Right to Buy) | |
| Yale Catriona | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 29.11 per share. | 16 Dec 2024 | 9,074 | 95,648 (0%) | 0% | 29.1 | 264,117 | Common Stock |
| Rolph Timothy | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2024 | 20,000 | 198,337 (0%) | 0% | 0 | Common Stock | |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 2,450 | 138,755 | - | - | Stock Option (Right to Buy) | |
| Rolph Timothy | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 31.03 per share. | 10 Dec 2024 | 2,450 | 178,337 (0%) | 0% | 31.0 | 76,024 | Common Stock |
| Lamy Patrick | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 30.79 per share. | 10 Dec 2024 | 925 | 17,858 (0%) | 0% | 30.8 | 28,481 | Common Stock |
| Rolph Timothy | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.87 per share. | 10 Dec 2024 | 2,450 | 180,787 (0%) | 0% | 19.9 | 48,682 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 30.79 per share. | 10 Dec 2024 | 2,368 | 178,337 (0%) | 0% | 30.8 | 72,911 | Common Stock |
| Young Jonathan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 30.79 per share. | 10 Dec 2024 | 2,503 | 203,783 (0%) | 0% | 30.8 | 77,067 | Common Stock |
| White William R. | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 30.79 per share. | 10 Dec 2024 | 2,817 | 38,335 (0%) | 0% | 30.8 | 86,735 | Common Stock |
| Cheng Andrew | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 30.79 per share. | 10 Dec 2024 | 7,855 | 597,562 (2%) | 0% | 30.8 | 241,855 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 30.79 per share. | 10 Dec 2024 | 2,810 | 71,348 (0%) | 0% | 30.8 | 86,520 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 32.13 per share. | 02 Dec 2024 | 10,000 | 206,286 (0%) | 0% | 32.1 | 321,310 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.09 per share. | 02 Dec 2024 | 25,000 | 605,417 (2%) | 0% | 32.1 | 802,250 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 02 Dec 2024 | 25,000 | 630,417 (2%) | 0% | 21.1 | 527,500 | Common Stock |
| Cheng Andrew | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2024 | 25,000 | 111,029 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 15 Nov 2024 | 9,061 | 83,219 (0%) | 0% | 21.1 | 191,187 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Nov 2024 | 9,061 | 53,421 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 28.82 per share. | 15 Nov 2024 | 300 | 74,158 (0%) | 0% | 28.8 | 8,647 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 27.69 per share. | 15 Nov 2024 | 8,761 | 74,458 (0%) | 0% | 27.7 | 242,627 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Nov 2024 | 1,110 | 16,849 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 06 Nov 2024 | 10,000 | 84,158 (0%) | 0% | 0.6 | 6,150 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Nov 2024 | 8,890 | 0 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 35.19 per share. | 06 Nov 2024 | 10,000 | 74,158 (0%) | 0% | 35.2 | 351,890 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 01 Nov 2024 | 81,280 | 686,697 (2%) | 0% | 21.1 | 1,715,008 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 27,086 | 136,029 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 81,280 | 163,115 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.50 per share. | 01 Nov 2024 | 27,086 | 605,417 (2%) | 0% | 32.5 | 880,268 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 01 Nov 2024 | 27,086 | 632,503 (2%) | 0% | 21.1 | 571,515 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.47 per share. | 01 Nov 2024 | 81,280 | 605,417 (2%) | 0% | 31.5 | 2,558,044 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 32.27 per share. | 01 Nov 2024 | 15,481 | 216,578 (0%) | 0% | 32.3 | 499,525 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 31.25 per share. | 01 Nov 2024 | 34,943 | 232,059 (0%) | 0% | 31.3 | 1,092,109 | Common Stock |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.09 per share. | 01 Nov 2024 | 40,716 | 267,002 (0%) | 0% | 21.1 | 858,700 | Common Stock |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 40,716 | 0 | - | - | Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 32.94 per share. | 01 Nov 2024 | 292 | 216,286 (0%) | 0% | 32.9 | 9,618 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 30 Oct 2024 | 15,485 | 89,643 (0%) | 0% | 21.1 | 326,734 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 32.53 per share. | 30 Oct 2024 | 4,515 | 74,158 (0%) | 0% | 32.5 | 146,855 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 30 Oct 2024 | 4,515 | 78,673 (0%) | 0% | 21.1 | 95,267 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 15,485 | 41,781 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 4,515 | 57,266 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 32.62 per share. | 30 Oct 2024 | 15,485 | 74,158 (0%) | 0% | 32.6 | 505,105 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 16 Oct 2024 | 24,992 | 630,409 (2%) | 0% | 21.1 | 527,331 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.14 per share. | 16 Oct 2024 | 24,992 | 605,417 (2%) | 0% | 31.1 | 778,151 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 16 Oct 2024 | 3,103 | 608,520 (2%) | 0% | 21.1 | 65,473 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.12 per share. | 16 Oct 2024 | 3,103 | 605,417 (2%) | 0% | 31.1 | 96,559 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 16 Oct 2024 | 63,539 | 668,956 (2%) | 0% | 21.1 | 1,340,673 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.53 per share. | 16 Oct 2024 | 63,313 | 605,643 (2%) | 0% | 31.5 | 1,996,069 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.12 per share. | 16 Oct 2024 | 226 | 605,417 (2%) | 0% | 32.1 | 7,259 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Oct 2024 | 24,992 | 160,351 | - | - | Stock Option (Righto Buy) | |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Oct 2024 | 3,103 | 157,248 | - | - | Stock Option (Righto Buy) | |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Oct 2024 | 63,539 | 93,709 | - | - | Stock Option (Righto Buy) | |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 30.15 per share. | 14 Oct 2024 | 40,000 | 226,286 (0%) | 0% | 30.2 | 1,206,080 | Common Stock |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2024 | 40,000 | 40,716 | - | - | Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.09 per share. | 14 Oct 2024 | 40,000 | 266,286 (0%) | 0% | 21.1 | 843,600 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 30.50 per share. | 14 Oct 2024 | 14,525 | 75,594 (0%) | 0% | 30.5 | 442,954 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2024 | 10,000 | 17,959 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2024 | 5,000 | 8,890 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2024 | 4,825 | 13,890 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 30.03 per share. | 14 Oct 2024 | 6,136 | 74,158 (0%) | 0% | 30.0 | 184,258 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 14 Oct 2024 | 5,000 | 80,294 (0%) | 0% | 0.6 | 3,075 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 30.93 per share. | 14 Oct 2024 | 300 | 75,294 (0%) | 0% | 30.9 | 9,278 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.61 per share. | 14 Oct 2024 | 14,825 | 90,119 (0%) | 0% | 0.6 | 9,117 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 28.18 per share. | 01 Oct 2024 | 10,000 | 226,286 (0%) | 0% | 28.2 | 281,770 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 19 Sep 2024 | 5,500 | 80,794 (0%) | 0% | 0.6 | 3,383 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Sep 2024 | 5,500 | 27,959 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 27.65 per share. | 19 Sep 2024 | 5,500 | 75,294 (0%) | 0% | 27.7 | 152,086 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.61 per share. | 16 Sep 2024 | 2,485 | 77,779 (0%) | 0% | 0.6 | 1,528 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2024 | 3,871 | 33,459 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2024 | 2,037 | 37,330 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2024 | 2,485 | 39,367 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 27.56 per share. | 16 Sep 2024 | 3,871 | 75,294 (0%) | 0% | 27.6 | 106,685 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 16 Sep 2024 | 3,871 | 79,165 (0%) | 0% | 0.6 | 2,381 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 27.55 per share. | 16 Sep 2024 | 2,037 | 75,294 (0%) | 0% | 27.5 | 56,115 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 16 Sep 2024 | 2,037 | 77,331 (0%) | 0% | 0.6 | 1,253 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 27.52 per share. | 16 Sep 2024 | 2,485 | 75,294 (0%) | 0% | 27.5 | 68,375 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 26.18 per share. | 13 Sep 2024 | 568 | 236,286 (0%) | 0% | 26.2 | 14,870 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 26.18 per share. | 10 Sep 2024 | 1,738 | 605,417 (2%) | 0% | 26.2 | 45,501 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 26.18 per share. | 10 Sep 2024 | 639 | 41,152 (0%) | 0% | 26.2 | 16,729 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 26.18 per share. | 10 Sep 2024 | 537 | 180,705 (0%) | 0% | 26.2 | 14,059 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 26.18 per share. | 10 Sep 2024 | 637 | 75,294 (0%) | 0% | 26.2 | 16,677 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 27.58 per share. | 03 Sep 2024 | 1,290 | 236,854 (0%) | 0% | 27.6 | 35,573 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 26.42 per share. | 03 Sep 2024 | 3,710 | 238,144 (0%) | 0% | 26.4 | 98,014 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 949 | 18,715 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 27.61 per share. | 03 Sep 2024 | 949 | 75,931 (0%) | 0% | 27.6 | 26,206 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 03 Sep 2024 | 949 | 76,880 (0%) | 0% | 0.6 | 584 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.01 per share. | 26 Aug 2024 | 32,671 | 74,462 (0%) | 0% | 7.0 | 228,991 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2024 | 23,175 | 24,745 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2024 | 18,116 | 47,920 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2024 | 24,372 | 116,833 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2024 | 32,671 | 0 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 26.41 per share. | 26 Aug 2024 | 23,175 | 41,791 (0%) | 0% | 26.4 | 612,098 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.09 per share. | 26 Aug 2024 | 23,175 | 64,966 (0%) | 0% | 21.1 | 488,761 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.21 per share. | 26 Aug 2024 | 18,116 | 41,791 (0%) | 0% | 27.2 | 492,954 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.09 per share. | 26 Aug 2024 | 18,116 | 59,907 (0%) | 0% | 21.1 | 382,066 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.21 per share. | 26 Aug 2024 | 24,372 | 41,791 (0%) | 0% | 27.2 | 663,186 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.87 per share. | 26 Aug 2024 | 24,372 | 66,163 (0%) | 0% | 19.9 | 484,272 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.21 per share. | 26 Aug 2024 | 32,671 | 41,791 (0%) | 0% | 27.2 | 889,011 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.61 per share. | 23 Aug 2024 | 8,851 | 84,782 (0%) | 0% | 0.6 | 5,443 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2024 | 5,200 | 19,664 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2024 | 8,851 | 24,864 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 27.51 per share. | 23 Aug 2024 | 5,200 | 75,931 (0%) | 0% | 27.5 | 143,073 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 23 Aug 2024 | 5,200 | 81,131 (0%) | 0% | 0.6 | 3,198 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 27.53 per share. | 23 Aug 2024 | 8,851 | 75,931 (0%) | 0% | 27.5 | 243,641 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 16 Aug 2024 | 24,538 | 607,155 (2%) | 0% | 0.6 | 15,091 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Aug 2024 | 24,538 | 0 | - | - | Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 27.23 per share. | 01 Aug 2024 | 1,969 | 241,854 (0%) | 0% | 27.2 | 53,616 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 26.44 per share. | 01 Aug 2024 | 3,031 | 243,823 (0%) | 0% | 26.4 | 80,140 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.01 per share. | 23 Jul 2024 | 500 | 41,791 (0%) | 0% | 28.0 | 14,005 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.01 per share. | 23 Jul 2024 | 500 | 42,291 (0%) | 0% | 7.0 | 3,505 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jul 2024 | 22,272 | 32,671 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jul 2024 | 139,083 | 54,943 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jul 2024 | 500 | 194,026 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.66 per share. | 23 Jul 2024 | 20,481 | 41,791 (0%) | 0% | 27.7 | 566,463 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.00 per share. | 23 Jul 2024 | 1,791 | 62,272 (0%) | 0% | 27 | 48,357 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.01 per share. | 23 Jul 2024 | 22,272 | 64,063 (0%) | 0% | 7.0 | 156,104 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 27.19 per share. | 23 Jul 2024 | 79,446 | 41,791 (0%) | 0% | 27.2 | 2,160,137 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 26.71 per share. | 23 Jul 2024 | 59,637 | 121,237 (0%) | 0% | 26.7 | 1,592,904 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.01 per share. | 23 Jul 2024 | 139,083 | 180,874 (0%) | 0% | 7.0 | 974,833 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jul 2024 | 29,803 | 194,526 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.04 per share. | 16 Jul 2024 | 5,008 | 41,791 (0%) | 0% | 28.0 | 140,449 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.04 per share. | 16 Jul 2024 | 29,803 | 46,799 (0%) | 0% | 28.0 | 835,825 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.01 per share. | 16 Jul 2024 | 29,803 | 76,602 (0%) | 0% | 7.0 | 208,889 | Common Stock |
| Andrew Cheng | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 19.94 per share. | 28 Jun 2024 | 1,064 | 582,617 (2%) | 0% | 19.9 | 21,217 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 23.40 per share. | 28 Jun 2024 | 5,000 | 246,854 (0%) | 0% | 23.4 | 117,020 | Common Stock |
| Jonathan Young | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 19.94 per share. | 28 Jun 2024 | 1,064 | 251,854 (0%) | 0% | 19.9 | 21,217 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 19.94 per share. | 28 Jun 2024 | 1,064 | 181,242 (0%) | 0% | 19.9 | 21,217 | Common Stock |
| Catriona Yale | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 19.94 per share. | 28 Jun 2024 | 1,064 | 75,931 (0%) | 0% | 19.9 | 21,217 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Grant, award, or other acquisition of securities at price $ 19.94 per share. | 28 Jun 2024 | 221 | 18,783 (0%) | 0% | 19.9 | 4,407 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 22.64 per share. | 11 Jun 2024 | 7,894 | 581,553 (2%) | 0% | 22.6 | 178,728 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 22.64 per share. | 11 Jun 2024 | 2,516 | 250,790 (0%) | 0% | 22.6 | 56,965 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 22.64 per share. | 11 Jun 2024 | 2,831 | 46,799 (0%) | 0% | 22.6 | 64,094 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 22.64 per share. | 11 Jun 2024 | 2,380 | 180,178 (0%) | 0% | 22.6 | 53,886 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 22.64 per share. | 11 Jun 2024 | 2,825 | 74,867 (0%) | 0% | 22.6 | 63,961 | Common Stock |
| Patrick Lamy | Senior VP, Commercial Strategy | Sale of securities on an exchange or to another person at price $ 22.64 per share. | 11 Jun 2024 | 569 | 18,562 (0%) | 0% | 22.6 | 12,883 | Common Stock |
| Jane Pritchett Henderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2024 | 26,000 | 26,000 | - | - | Stock Option (Right to Buy) | |
| Mark T. Iwicki | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2024 | 26,000 | 26,000 | - | - | Stock Option (Right to Buy) | |
| Seth L. Harrison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2024 | 26,000 | 26,000 | - | - | Stock Option (Right to Buy) | |
| Graham Walmsley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2024 | 26,000 | 26,000 | - | - | Stock Option (Right to Buy) | |
| Tomas J. Heyman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2024 | 26,000 | 26,000 | - | - | Stock Option (Right to Buy) | |
| Yuan Xu | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2024 | 26,000 | 26,000 | - | - | Stock Option (Right to Buy) | |
| Judy Chou | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2024 | 26,000 | 26,000 | - | - | Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.29 per share. | 03 Jun 2024 | 5,000 | 253,306 (0%) | 0% | 19.3 | 96,440 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 20.15 per share. | 01 May 2024 | 5,000 | 258,306 (0%) | 0% | 20.2 | 100,750 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 25.02 per share. | 01 Apr 2024 | 400 | 263,306 (0%) | 0% | 25.0 | 10,010 | Common Stoek |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 24.33 per share. | 01 Apr 2024 | 4,600 | 263,706 (0%) | 0% | 24.3 | 111,903 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 28.33 per share. | 13 Mar 2024 | 1,969 | 589,447 (2%) | 0% | 28.3 | 55,782 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 28.33 per share. | 13 Mar 2024 | 651 | 268,306 (0%) | 0% | 28.3 | 18,443 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 28.33 per share. | 13 Mar 2024 | 724 | 49,630 (0%) | 0% | 28.3 | 20,511 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.33 per share. | 13 Mar 2024 | 619 | 182,558 (0%) | 0% | 28.3 | 17,536 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 28.33 per share. | 13 Mar 2024 | 723 | 77,692 (0%) | 0% | 28.3 | 20,483 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 35.49 per share. | 04 Mar 2024 | 7,995 | 591,530 (2%) | 0% | 35.5 | 283,775 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 32.28 per share. | 04 Mar 2024 | 6,770 | 623,819 (2%) | 0% | 32.3 | 218,538 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 04 Mar 2024 | 57,733 | 649,149 (2%) | 0% | 16 | 923,728 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 04 Mar 2024 | 17,267 | 666,416 (2%) | 0% | 21.1 | 364,334 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 31.40 per share. | 04 Mar 2024 | 35,827 | 630,589 (2%) | 0% | 31.4 | 1,124,975 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 34.63 per share. | 04 Mar 2024 | 14,680 | 599,525 (2%) | 0% | 34.6 | 508,373 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 33.83 per share. | 04 Mar 2024 | 9,614 | 614,205 (2%) | 0% | 33.8 | 325,267 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2024 | 17,267 | 244,395 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2024 | 57,733 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 36.28 per share. | 04 Mar 2024 | 114 | 591,416 (2%) | 0% | 36.3 | 4,136 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2024 | 10,646 | 74,354 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 04 Mar 2024 | 10,000 | 88,415 (0%) | 0% | 6.4 | 63,600 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.09 per share. | 04 Mar 2024 | 10,646 | 99,061 (0%) | 0% | 21.1 | 224,524 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 35.49 per share. | 04 Mar 2024 | 20,646 | 78,415 (0%) | 0% | 35.5 | 732,727 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2024 | 10,000 | 15,172 | - | - | Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2024 | 83,321 | 0 | - | - | Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.61 per share. | 01 Mar 2024 | 83,321 | 268,957 (0%) | 0% | 0.6 | 51,242 | Common Stock |
| Cheng Andrew | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 02 Jan 2024 | 40,000 | 590,911 (2%) | 0% | 0.6 | 24,600 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2024 | 40,000 | 24,538 | - | - | Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 27 Dec 2023 | 5,414 | 190,545 (0%) | 0% | 6.4 | 34,433 | Common Stock |
| Young Jonathan | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2023 | 5,414 | 43,064 | - | - | Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 24.00 per share. | 27 Dec 2023 | 5,414 | 185,131 (0%) | 0% | 24 | 129,936 | Common Stock |
| Rolph Timothy | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 20.76 per share. | 14 Dec 2023 | 514 | 182,672 (0%) | 0% | 20.8 | 10,671 | Common Stock |
| Cheng Andrew | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.76 per share. | 14 Dec 2023 | 1,628 | 550,911 (1%) | 0% | 20.8 | 33,797 | Common Stock |
| William White R. | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.76 per share. | 14 Dec 2023 | 611 | 50,354 (0%) | 0% | 20.8 | 12,684 | Common Stock |
| Young Jonathan | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 20.76 per share. | 14 Dec 2023 | 543 | 185,131 (0%) | 0% | 20.8 | 11,273 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 20.76 per share. | 14 Dec 2023 | 597 | 77,910 (0%) | 0% | 20.8 | 12,394 | Common Stock |
| White William R. | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 32,497 | 50,965 (0%) | 0% | 0 | Common Stock | |
| Walmsley Graham | Director | Purchase of securities on an exchange or from another person at price $ 19.80 per share. | 08 Dec 2023 | 50,000 | 750,000 (2%) | 0% | 19.8 | 990,240 | Common Stock |
| Rolph Timothy | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 146,237 | 146,237 | - | - | Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 146,237 | 146,237 | - | - | Stock Option (Right to Buy) | |
| Walmsley Graham | Director | Purchase of securities on an exchange or from another person at price $ 19.85 per share. | 08 Dec 2023 | 50,000 | 800,000 (2%) | 0% | 19.9 | 992,700 | Common Stock |
| William White R. | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 146,237 | 146,237 | - | - | Stock Option (Right to Buy) | |
| Patrick Lamy | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 18,570 | 18,570 (0%) | 0% | 0 | Common Stock | |
| Young Jonathan | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 32,497 | 185,674 (0%) | 0% | 0 | Common Stock | |
| Yale Catriona | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 146,237 | 146,237 | - | - | Stock Option (Right to Buy) | |
| Yale Catriona | Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 32,497 | 78,507 (0%) | 0% | 0 | Common Stock | |
| Rolph Timothy | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 32,497 | 183,186 (0%) | 0% | 0 | Common Stock | |
| Lamy Patrick | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Dec 2023 | 83,564 | 83,564 | - | - | Stock Option (Right to Buy) | |
| Cheng Andrew | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.02 per share. | 07 Dec 2023 | 6,700 | 460,998 (1%) | 0% | 20.0 | 134,125 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.01 per share. | 07 Dec 2023 | 12,873 | 460,998 (1%) | 0% | 20.0 | 257,571 | Common Stock |
| Cheng Andrew | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 07 Dec 2023 | 6,700 | 467,698 (1%) | 0% | 6.4 | 42,612 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 07 Dec 2023 | 7,405 | 559,944 (1%) | 0% | 6.4 | 47,096 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2023 | 7,405 | 13,022 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2023 | 6,700 | 33,300 | - | - | Stock Option (Right to Buy) | |
| Cheng Andrew | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 20.02 per share. | 07 Dec 2023 | 7,405 | 552,539 (1%) | 0% | 20.0 | 148,273 | Common Stock |
| Andrew Cheng | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Dec 2023 | 91,541 | 552,539 (1%) | 0% | 0 | Common Stock | |
| Andrew Cheng | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Dec 2023 | 411,936 | 411,936 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Dec 2023 | 12,873 | 20,427 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 07 Dec 2023 | 12,873 | 473,871 (1%) | 0% | 6.4 | 81,872 | Common Stock |
| Walmsley Graham | Director | Purchase of securities on an exchange or from another person at price $ 16.99 per share. | 30 Nov 2023 | 50,000 | 700,000 (2%) | 0% | 17.0 | 849,730 | Common Stock |
| Graham Walmsley | Director | Purchase of securities on an exchange or from another person at price $ 16.90 per share. | 30 Nov 2023 | 50,000 | 650,000 (2%) | 0% | 16.9 | 844,835 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Aug 2023 | 15,000 | 102,212 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 30 Aug 2023 | 15,000 | 462,680 (1%) | 0% | 0.6 | 9,225 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 28 Aug 2023 | 5,745 | 52,372 (0%) | 0% | 6.4 | 36,538 | Common Stock |
| Catriona Yale | Chief Development Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Aug 2023 | 5,745 | 30,172 | - | - | Stock Option (Right to Buy) | |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 50.67 per share. | 28 Aug 2023 | 500 | 46,627 (0%) | 0% | 50.7 | 25,335 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 49.92 per share. | 28 Aug 2023 | 5,245 | 47,127 (0%) | 0% | 49.9 | 261,856 | Common Stock |
| Graham Walmsley | Director | Purchase of securities on an exchange or from another person at price $ 42.06 per share. | 08 Aug 2023 | 25,000 | 600,000 (2%) | 0% | 42.1 | 1,051,475 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 42.85 per share. | 01 Aug 2023 | 13,679 | 459,001 (1%) | 0% | 42.9 | 586,164 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2023 | 25,000 | 90,000 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 43.52 per share. | 01 Aug 2023 | 11,321 | 447,680 (1%) | 0% | 43.5 | 492,702 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 01 Aug 2023 | 25,000 | 472,680 (1%) | 0% | 6.4 | 159,000 | Common Stock |
| Graham Walmsley | Director | Purchase of securities on an exchange or from another person at price $ 43.26 per share. | 28 Jul 2023 | 25,000 | 575,000 (2%) | 0% | 43.3 | 1,081,525 | Common Stock |
| Graham Walmsley | Director | Purchase of securities on an exchange or from another person at price $ 42.69 per share. | 28 Jul 2023 | 30,000 | 550,000 (1%) | 0% | 42.7 | 1,280,709 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 44.66 per share. | 03 Jul 2023 | 18,730 | 453,950 (1%) | 0% | 44.7 | 836,493 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jul 2023 | 25,000 | 115,000 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 46.29 per share. | 03 Jul 2023 | 1,219 | 447,680 (1%) | 0% | 46.3 | 56,427 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 45.36 per share. | 03 Jul 2023 | 5,051 | 448,899 (1%) | 0% | 45.4 | 229,121 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 03 Jul 2023 | 25,000 | 472,680 (1%) | 0% | 6.4 | 159,000 | Common Stock |
| Mark T. Iwicki | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jun 2023 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Seth L. Harrison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jun 2023 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Graham Walmsley | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Jun 2023 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 55.00 per share. | 20 Jun 2023 | 20,777 | 19,100 (0%) | 0% | 55 | 1,142,735 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jun 2023 | 17,500 | 224,329 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.01 per share. | 20 Jun 2023 | 17,500 | 39,877 (0%) | 0% | 7.0 | 122,658 | Common Stock |
| Jane Pritchett Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.01 per share. | 16 Jun 2023 | 40,000 | 40,000 (0%) | 0% | 7.0 | 280,400 | Common Stock |
| Jane Pritchett Henderson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 40,000 | 14,797 | - | - | Stock Option (Right to Buy) | |
| Jane Pritchett Henderson | Director | Sale of securities on an exchange or to another person at price $ 54.46 per share. | 16 Jun 2023 | 22,498 | 0 (0%) | 0% | 54.5 | 1,225,291 | Common Stock |
| Jane Pritchett Henderson | Director | Sale of securities on an exchange or to another person at price $ 53.79 per share. | 16 Jun 2023 | 17,502 | 22,498 (0%) | 0% | 53.8 | 941,394 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 40,000 | 2,796 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 56.30 per share. | 16 Jun 2023 | 1,413 | 151,220 (0%) | 0% | 56.3 | 79,547 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 55.08 per share. | 16 Jun 2023 | 27,462 | 152,633 (0%) | 0% | 55.1 | 1,512,607 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 54.58 per share. | 16 Jun 2023 | 49,325 | 180,095 (0%) | 0% | 54.6 | 2,691,912 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.61 per share. | 16 Jun 2023 | 40,000 | 229,420 (0%) | 0% | 0.6 | 24,400 | Common Stock |
| Tomas J. Heyman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2023 | 26,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Tomas J. Heyman | Director | Sale of securities on an exchange or to another person at price $ 54.67 per share. | 16 Jun 2023 | 26,000 | 0 (0%) | 0% | 54.7 | 1,421,529 | Common Stock |
| Tomas J. Heyman | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 25.04 per share. | 16 Jun 2023 | 26,000 | 26,000 (0%) | 0% | 25.0 | 651,040 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 55.16 per share. | 13 Jun 2023 | 1,613 | 407,680 (1%) | 0% | 55.2 | 88,973 | Common Stock |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 55.16 per share. | 13 Jun 2023 | 538 | 183,739 (0%) | 0% | 55.2 | 29,676 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 55.16 per share. | 13 Jun 2023 | 606 | 22,377 (0%) | 0% | 55.2 | 33,427 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 55.16 per share. | 13 Jun 2023 | 509 | 189,420 (0%) | 0% | 55.2 | 28,076 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 55.16 per share. | 13 Jun 2023 | 591 | 79,976 (0%) | 0% | 55.2 | 32,600 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2023 | 3,670 | 140,000 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 01 Jun 2023 | 21,330 | 430,623 (1%) | 0% | 0.6 | 13,118 | Common Stock |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2023 | 21,330 | 64,538 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 01 Jun 2023 | 3,670 | 434,293 (1%) | 0% | 6.4 | 23,341 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 45.90 per share. | 01 Jun 2023 | 400 | 409,293 (1%) | 0% | 45.9 | 18,359 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 45.26 per share. | 01 Jun 2023 | 20,686 | 409,693 (1%) | 0% | 45.3 | 936,170 | Common Stock |
| Andrew Cheng | Director, President and CEO | Sale of securities on an exchange or to another person at price $ 44.18 per share. | 01 Jun 2023 | 3,914 | 430,379 (1%) | 0% | 44.2 | 172,902 | Common Stock |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 18 Apr 2023 | 40,000 | 409,293 (1%) | 0% | 0.6 | 24,600 | Common Stock |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2023 | 25,000 | 85,868 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2023 | 40,000 | 157,212 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 45.50 per share. | 18 Apr 2023 | 3,477 | 409,293 (1%) | 0% | 45.5 | 158,219 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 18 Apr 2023 | 21,523 | 412,770 (1%) | 0% | 45.0 | 968,640 | Common Stock |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 18 Apr 2023 | 25,000 | 434,293 (1%) | 0% | 0.6 | 15,375 | Common Stock |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 03 Apr 2023 | 25,000 | 394,293 (1%) | 0% | 0.6 | 15,375 | Common Stock |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Apr 2023 | 25,000 | 110,868 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 38.83 per share. | 03 Apr 2023 | 1,708 | 369,293 (1%) | 0% | 38.8 | 66,315 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 37.88 per share. | 03 Apr 2023 | 23,292 | 371,001 (1%) | 0% | 37.9 | 882,261 | Common Stock |
| Andrew Cheng | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 43.47 per share. | 10 Mar 2023 | 1,706 | 369,293 (1%) | 0% | 43.5 | 74,160 | Common Stock |
| Jonathan Young | Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 43.47 per share. | 10 Mar 2023 | 634 | 184,277 (0%) | 0% | 43.5 | 27,560 | Common Stock |
| William R. White | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 43.47 per share. | 10 Mar 2023 | 641 | 22,983 (0%) | 0% | 43.5 | 27,864 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 43.47 per share. | 10 Mar 2023 | 603 | 189,929 (0%) | 0% | 43.5 | 26,212 | Common Stock |
| Catriona Yale | Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 43.46 per share. | 10 Mar 2023 | 701 | 80,567 (0%) | 0% | 43.5 | 30,465 | Common Stock |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 01 Mar 2023 | 25,000 | 395,999 (1%) | 0% | 0.6 | 15,375 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 45.54 per share. | 01 Mar 2023 | 2,265 | 393,734 (1%) | 0% | 45.5 | 103,151 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 46.60 per share. | 01 Mar 2023 | 16,035 | 377,699 (1%) | 0% | 46.6 | 747,154 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 47.17 per share. | 01 Mar 2023 | 6,700 | 370,999 (1%) | 0% | 47.2 | 316,034 | Common Stock |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2023 | 25,000 | 135,868 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 01 Feb 2023 | 25,000 | 395,999 (1%) | 0% | 0.6 | 15,375 | Common Stock |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2023 | 25,000 | 160,868 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 50.14 per share. | 01 Feb 2023 | 2,000 | 370,999 (1%) | 0% | 50.1 | 100,284 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 49.67 per share. | 01 Feb 2023 | 8,155 | 372,999 (1%) | 0% | 49.7 | 405,054 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 48.57 per share. | 01 Feb 2023 | 14,845 | 381,154 (1%) | 0% | 48.6 | 721,057 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 49.12 per share. | 13 Jan 2023 | 1,048 | 85,220 (0%) | 0% | 49.1 | 51,476 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 51.99 per share. | 13 Jan 2023 | 1,105 | 81,268 (0%) | 0% | 52.0 | 57,446 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 51.18 per share. | 13 Jan 2023 | 1,313 | 82,373 (0%) | 0% | 51.2 | 67,197 | Common Stock |
| Catriona Yale | Chief Development Officer | Sale of securities on an exchange or to another person at price $ 49.89 per share. | 13 Jan 2023 | 1,534 | 83,686 (0%) | 0% | 49.9 | 76,531 | Common Stock |
| Patrick Lamy | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2023 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 50.12 per share. | 03 Jan 2023 | 13,200 | 382,799 (1%) | 0% | 50.1 | 661,583 | Common Stock |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2023 | 25,000 | 185,868 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 54.81 per share. | 03 Jan 2023 | 300 | 370,999 (1%) | 0% | 54.8 | 16,442 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 54.37 per share. | 03 Jan 2023 | 3,900 | 371,299 (1%) | 0% | 54.4 | 212,047 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 53.09 per share. | 03 Jan 2023 | 800 | 375,199 (1%) | 0% | 53.1 | 42,470 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 52.03 per share. | 03 Jan 2023 | 3,000 | 375,999 (1%) | 0% | 52.0 | 156,096 | Common Stock |
| Andrew Cheng | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 50.82 per share. | 03 Jan 2023 | 3,800 | 378,999 (1%) | 0% | 50.8 | 193,114 | Common Stock |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 03 Jan 2023 | 25,000 | 395,999 (1%) | 0% | 0.6 | 15,375 | Common Stock |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 03 Jan 2023 | 8,777 | 193,688 (0%) | 0% | 0.6 | 5,398 | Common Stock |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2023 | 8,777 | 83,321 | - | - | Employee Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 54.64 per share. | 03 Jan 2023 | 8,777 | 184,911 (0%) | 0% | 54.6 | 479,560 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2022 | 7,816 | 66,267 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2022 | 1,700 | 74,083 | - | - | Stock Option (Right to Buy) | |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 51.38 per share. | 28 Dec 2022 | 12,293 | 190,532 (0%) | 0% | 51.4 | 631,571 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.55 per share. | 28 Dec 2022 | 8,023 | 202,825 (0%) | 0% | 50.5 | 405,547 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 28 Dec 2022 | 1,700 | 203,032 (0%) | 0% | 50.0 | 85,006 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.35 per share. | 28 Dec 2022 | 7,816 | 210,848 (0%) | 0% | 28.4 | 221,584 | Common Stock |
| Timothy Rolph | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.35 per share. | 28 Dec 2022 | 1,700 | 204,732 (0%) | 0% | 28.4 | 48,195 | Common Stock |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2022 | 11,778 | 48,478 | - | - | Employee Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2022 | 722 | 92,098 | - | - | Employee Stock Option (Right to Buy) | |
| Jonathan Young | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 49.57 per share. | 27 Dec 2022 | 12,500 | 182,449 (0%) | 0% | 49.6 | 619,609 | Common Stock |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.36 per share. | 27 Dec 2022 | 11,778 | 194,949 (0%) | 0% | 6.4 | 74,908 | Common Stock |
| Jonathan Young | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.61 per share. | 27 Dec 2022 | 722 | 183,171 (0%) | 0% | 0.6 | 444 | Common Stock |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 49.77 per share. | 27 Dec 2022 | 19,001 | 23,624 (0%) | 0% | 49.8 | 945,609 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2022 | 999 | 241,829 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Dec 2022 | 19,001 | 242,828 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 49.76 per share. | 27 Dec 2022 | 999 | 23,624 (0%) | 0% | 49.8 | 49,714 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.01 per share. | 27 Dec 2022 | 999 | 24,623 (0%) | 0% | 7.0 | 7,002 | Common Stock |
| William R. White | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.01 per share. | 27 Dec 2022 | 19,001 | 42,625 (0%) | 0% | 7.0 | 133,178 | Common Stock |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Dec 2022 | 8,500 | 197,212 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2022 | 87,220 | 261,662 | - | - | Stock Option (Right to Buy) | |
| Andrew Cheng | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.62 per share. | 16 Dec 2022 | 8,500 | 370,999 (1%) | 0% | 0.6 | 5,228 | Common Stock |
| Jonathan Young | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2022 | 29,073 | 87,221 | - | - | Stock Option (Right to Buy) | |
| William R. White | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2022 | 29,073 | 87,221 | - | - | Stock Option (Right to Buy) |