8.6M XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 1.83 per share. | 03 Mar 2025 | 7,144 | 809,090 (0%) | 0% | 1.8 | 13,074 | Common Stock |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 1.83 per share. | 03 Mar 2025 | 46,409 | 2,557,921 (2%) | 0% | 1.8 | 84,928 | Common Stock |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 2.10 per share. | 31 Jan 2025 | 97,982 | 2,604,330 (2%) | 0% | 2.1 | 205,762 | Common Stock |
| Richard C. Malabre | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 128,000 | 128,000 | - | - | Stock Option (Right to buy) | |
| Richard C. Malabre | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 2.10 per share. | 31 Jan 2025 | 30,202 | 280,248 (0%) | 0% | 2.1 | 63,424 | Common Stock |
| Richard C. Malabre | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 85,000 | 310,450 (0%) | 0% | 0 | Common Stock | |
| Nicholas Grund | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 292,300 | 292,300 | - | - | Stock Option (Right to buy) | |
| Nicholas Grund | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 2.10 per share. | 31 Jan 2025 | 55,621 | 442,579 (0%) | 0% | 2.1 | 116,804 | Common Stock |
| Nicholas Grund | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 194,900 | 498,200 (0%) | 0% | 0 | Common Stock | |
| Erik John Ostrowski | SVP, CFO, CBO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 194,900 | 544,900 (0%) | 0% | 0 | Common Stock | |
| Erik John Ostrowski | SVP, CFO, CBO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 292,300 | 292,300 | - | - | Stock Option (Right to buy) | |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 2.10 per share. | 31 Jan 2025 | 27,236 | 816,234 (0%) | 0% | 2.1 | 57,196 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 194,900 | 866,740 (0%) | 0% | 0 | Common Stock | |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 292,300 | 292,300 | - | - | Stock Option (Right to buy) | |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 2.10 per share. | 31 Jan 2025 | 23,270 | 843,470 (0%) | 0% | 2.1 | 48,867 | Common Stock |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 2.10 per share. | 31 Jan 2025 | 46,268 | 2,702,312 (2%) | 0% | 2.1 | 97,163 | Common Stock |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 701,000 | 2,748,580 (2%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 1,051,400 | 1,051,400 | - | - | Stock Option (Right to buy) | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2025 | 350,500 | 350,500 | - | - | Performance Stock Units | |
| Ronald E. Frieson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2025 | 20,100 | 0 | - | - | Stock Option (Right to buy) | |
| Ronald E. Frieson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.45 per share. | 17 Jan 2025 | 20,100 | 93,800 (0%) | 0% | 0.5 | 9,045 | Common Stock |
| Erik John Ostrowski | SVP, CFO, CBO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2024 | 500,000 | 500,000 | - | - | Stock Option (Right to buy) | |
| Erik John Ostrowski | SVP, CFO, CBO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jun 2024 | 350,000 | 350,000 (0%) | 0% | 0 | Common Stock | |
| Michael W. Rogers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Ronald E. Frieson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 30,000 | 73,700 (0%) | 0% | 0 | Common Stock | |
| Ronald E. Frieson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Myles Wolf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Myles Wolf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 30,000 | 97,681 (0%) | 0% | 0 | Common Stock | |
| Cynthia Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 30,000 | 125,233 (0%) | 0% | 0 | Common Stock | |
| Cynthia Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Adrian Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 30,000 | 164,800 (0%) | 0% | 0 | Common Stock | |
| Adrian Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| LeAnne M. Zumwalt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| LeAnne M. Zumwalt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 30,000 | 73,700 (0%) | 0% | 0 | Common Stock | |
| Steven C. Gilman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Steven C. Gilman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 30,000 | 117,130 (0%) | 0% | 0 | Common Stock | |
| Michael W. Rogers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2024 | 30,000 | 126,029 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 1.26 per share. | 13 May 2024 | 12,016 | 651,243 (0%) | 0% | 1.3 | 15,140 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 1.26 per share. | 13 May 2024 | 34,840 | 672,092 (0%) | 0% | 1.3 | 43,898 | Common Stock |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 1.58 per share. | 29 Feb 2024 | 46,570 | 2,044,580 (1%) | 0% | 1.6 | 73,581 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 1.58 per share. | 29 Feb 2024 | 5,974 | 663,259 (0%) | 0% | 1.6 | 9,439 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 1.58 per share. | 29 Feb 2024 | 7,169 | 695,840 (0%) | 0% | 1.6 | 11,327 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 1.58 per share. | 29 Feb 2024 | 8,661 | 706,932 (0%) | 0% | 1.6 | 13,684 | Common Stock |
| Dahan Michel | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 1.52 per share. | 27 Feb 2024 | 10,744 | 715,593 (0%) | 0% | 1.5 | 16,331 | Common Stock |
| Burke Keith Steven | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 1.52 per share. | 27 Feb 2024 | 8,367 | 703,009 (0%) | 0% | 1.5 | 12,718 | Common Stock |
| Butler P. John | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 1.52 per share. | 27 Feb 2024 | 37,733 | 2,091,150 (1%) | 0% | 1.5 | 57,354 | Common Stock |
| Hadas R. Nicole | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 1.52 per share. | 27 Feb 2024 | 7,411 | 669,233 (0%) | 0% | 1.5 | 11,265 | Common Stock |
| P. Butler John | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 1.68 per share. | 31 Jan 2024 | 46,489 | 2,128,883 (1%) | 0% | 1.7 | 78,102 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 224,000 | 224,000 | - | - | Stock Option (Right to buy) | |
| E. Ellen Snow | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 224,000 | 224,000 | - | - | Stock Option (Right to buy) | |
| Richard Malabre C. | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 336,000 | 336,000 | - | - | Stock Option (Right to buy) | |
| Hadas R. Nicole | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 149,300 | 676,644 (0%) | 0% | 0 | Common Stock | |
| Steven Burke Keith | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 303,300 | 303,300 | - | - | Stock Option (Right to buy) | |
| Butler P. John | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 603,500 | 2,175,372 (1%) | 0% | 0 | Common Stock | |
| Richard Malabre C. | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 223,950 | 223,950 (0%) | 0% | 0 | Common Stock | |
| E. Snow Ellen | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 149,300 | 519,300 (0%) | 0% | 0 | Common Stock | |
| Dahan Michel | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 149,300 | 726,337 (0%) | 0% | 0 | Common Stock | |
| John Butler P. | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 905,200 | 905,200 | - | - | Stock Option (Right to buy) | |
| R. Nicole Hadas | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 224,000 | 224,000 | - | - | Stock Option (Right to buy) | |
| Steven Burke Keith | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 1.68 per share. | 31 Jan 2024 | 24,311 | 711,376 (0%) | 0% | 1.7 | 40,842 | Common Stock |
| Keith Burke Steven | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 202,200 | 735,687 (0%) | 0% | 0 | Common Stock | |
| Nicholas Grund | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 303,300 | 303,300 (0%) | 0% | 0 | Common Stock | |
| Nicholas Grund | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2024 | 454,950 | 454,950 | - | - | Stock Option (Right to buy) | |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 1.15 per share. | 25 Aug 2023 | 27,000 | 668,840 (0%) | 0% | 1.2 | 31,050 | Common Stock |
| Ellen E. Snow | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jul 2023 | 560,000 | 560,000 | - | - | Stock Option (Right to buy) | |
| Ellen E. Snow | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jul 2023 | 370,000 | 370,000 (0%) | 0% | 0 | Common Stock | |
| Adrian Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Adrian Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 30,000 | 134,800 (0%) | 0% | 0 | Common Stock | |
| LeAnne M. Zumwalt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 30,000 | 43,700 (0%) | 0% | 0 | Common Stock | |
| LeAnne M. Zumwalt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Steven C. Gilman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 30,000 | 87,130 (0%) | 0% | 0 | Common Stock | |
| Steven C. Gilman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Michael W. Rogers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 30,000 | 96,029 (0%) | 0% | 0 | Common Stock | |
| Michael W. Rogers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Cynthia Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Cynthia Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 30,000 | 95,233 (0%) | 0% | 0 | Common Stock | |
| Myles Wolf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Myles Wolf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 30,000 | 67,681 (0%) | 0% | 0 | Common Stock | |
| Ronald E. Frieson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Ronald E. Frieson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 30,000 | 43,700 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 200,000 | 200,000 | - | - | Employee Stock Option (Right to buy) | |
| Nicole R. Hadas | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 200,000 | 587,530 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 1.22 per share. | 24 May 2023 | 63,186 | 524,344 (0%) | 0% | 1.2 | 77,270 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 200,000 | 669,515 (0%) | 0% | 0 | Common Stock | |
| Michel Dahan | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 May 2023 | 200,000 | 200,000 | - | - | Employee Stock Option (Right to buy) | |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 1.22 per share. | 24 May 2023 | 95,478 | 574,037 (0%) | 0% | 1.2 | 116,760 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 1.07 per share. | 16 May 2023 | 63,567 | 530,487 (0%) | 0% | 1.1 | 67,890 | Common Stock |
| David A. Spellman | SVP, CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 1.07 per share. | 16 May 2023 | 63,567 | 446,483 (0%) | 0% | 1.1 | 67,890 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2023 | 100,000 | 387,530 (0%) | 0% | 0 | Common Stock | |
| Michel Dahan | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2023 | 200,000 | 469,515 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 47,239 | 1,575,242 (1%) | 0% | 0.9 | 41,452 | Common Stock |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 6,370 | 1,568,872 (1%) | 0% | 0.9 | 5,590 | Common Stock |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 38,259 | 1,622,481 (1%) | 0% | 0.9 | 33,572 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 5,333 | 295,231 (0%) | 0% | 0.9 | 4,680 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 6,613 | 288,618 (0%) | 0% | 0.9 | 5,803 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 1,088 | 287,530 (0%) | 0% | 0.9 | 955 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 6,400 | 595,164 (0%) | 0% | 0.9 | 5,616 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 6,613 | 601,564 (0%) | 0% | 0.9 | 5,803 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 1,110 | 594,054 (0%) | 0% | 0.9 | 974 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 8,058 | 281,869 (0%) | 0% | 0.9 | 7,071 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 10,476 | 271,393 (0%) | 0% | 0.9 | 9,193 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 1,878 | 269,515 (0%) | 0% | 0.9 | 1,648 | Common Stock |
| David A. Spellman | SVP, CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 6,400 | 510,860 (0%) | 0% | 0.9 | 5,616 | Common Stock |
| David A. Spellman | SVP, CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 0.88 per share. | 01 Mar 2023 | 810 | 510,050 (0%) | 0% | 0.9 | 711 | Common Stock |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 0.81 per share. | 27 Feb 2023 | 38,632 | 1,660,740 (1%) | 0% | 0.8 | 31,416 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 0.81 per share. | 27 Feb 2023 | 6,677 | 300,564 (0%) | 0% | 0.8 | 5,430 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 0.81 per share. | 27 Feb 2023 | 7,539 | 608,177 (0%) | 0% | 0.8 | 6,131 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.81 per share. | 27 Feb 2023 | 10,090 | 289,927 (0%) | 0% | 0.8 | 8,205 | Common Stock |
| David A. Spellman | SVP, CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 0.81 per share. | 27 Feb 2023 | 7,539 | 517,260 (0%) | 0% | 0.8 | 6,131 | Common Stock |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 875,000 | 875,000 | - | - | Stock Option (Right to buy) | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 635,313 | 635,313 | - | - | Stock Appreciation Right | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 293,125 | 1,699,372 (1%) | 0% | 0 | Common Stock | |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 294,300 | 294,300 | - | - | Stock Option (Right to buy) | |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 196,200 | 615,716 (0%) | 0% | 0 | Common Stock | |
| David A. Spellman | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 196,200 | 524,799 (0%) | 0% | 0 | Common Stock | |
| David A. Spellman | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jan 2023 | 294,300 | 294,300 | - | - | Stock Option (Right to buy) | |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 0.36 per share. | 31 Aug 2022 | 1,147 | 418,016 (0%) | 0% | 0.4 | 416 | Common Stock |
| Adrian Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 13,700 | 104,800 (0%) | 0% | 0 | Common Stock | |
| Adrian Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| LeAnne M. Zumwalt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| LeAnne M. Zumwalt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 13,700 | 13,700 (0%) | 0% | 0 | Common Stock | |
| Steven C. Gilman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Steven C. Gilman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 13,700 | 57,130 (0%) | 0% | 0 | Common Stock | |
| Michael W. Rogers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 13,700 | 66,029 (0%) | 0% | 0 | Common Stock | |
| Michael W. Rogers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Cynthia Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Cynthia Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 13,700 | 65,233 (0%) | 0% | 0 | Common Stock | |
| David A. Spellman | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 200,000 | 200,000 | - | - | Stock Option (Right to buy) | |
| David A. Spellman | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 200,000 | 328,599 (0%) | 0% | 0 | Common Stock | |
| Myles Wolf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 13,700 | 37,681 (0%) | 0% | 0 | Common Stock | |
| Myles Wolf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Ron Frieson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 13,700 | 13,700 (0%) | 0% | 0 | Common Stock | |
| Ron Frieson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2022 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Steven C. Gilman | Director | Sale of securities on an exchange or to another person at price $ 0.36 per share. | 03 Jun 2022 | 4,567 | 43,430 (0%) | 0% | 0.4 | 1,653 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2022 | 200,000 | 200,000 | - | - | Stock Option (Right to buy) | |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2022 | 200,000 | 417,663 (0%) | 0% | 0 | Common Stock | |
| Violetta Cotreau | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2022 | 150,000 | 219,954 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 2.15 per share. | 28 Feb 2022 | 25,053 | 1,164,095 (0%) | 0% | 2.2 | 53,984 | Common Stock |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 293,125 | 1,457,220 (1%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 24,811 | 1,432,409 (1%) | 0% | 2.2 | 53,857 | Common Stock |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 25,031 | 1,407,378 (1%) | 0% | 2.2 | 54,335 | Common Stock |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 4,131 | 1,403,247 (1%) | 0% | 2.2 | 8,967 | Common Stock |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 739,700 | 739,700 | - | - | Employee Stock Option (Right to buy) | |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 2.15 per share. | 28 Feb 2022 | 6,555 | 265,748 (0%) | 0% | 2.2 | 14,125 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 200,000 | 200,000 | - | - | Employee Stock Option (Right to buy) | |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 1,078 | 304,241 (0%) | 0% | 2.2 | 2,340 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 6,556 | 302,319 (0%) | 0% | 2.2 | 14,231 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 6,873 | 308,875 (0%) | 0% | 2.2 | 14,919 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 50,000 | 315,748 (0%) | 0% | 0 | Common Stock | |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 1,100 | 217,663 (0%) | 0% | 2.2 | 2,388 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 2.15 per share. | 28 Feb 2022 | 7,400 | 163,819 (0%) | 0% | 2.2 | 15,946 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 60,000 | 223,819 (0%) | 0% | 0 | Common Stock | |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 6,556 | 217,263 (0%) | 0% | 2.2 | 14,231 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 225,000 | 225,000 | - | - | Employee Stock Option (Right to buy) | |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 2.15 per share. | 28 Feb 2022 | 6,555 | 258,995 (0%) | 0% | 2.2 | 14,125 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 200,000 | 200,000 | - | - | Employee Stock Option (Right to buy) | |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 1,232 | 297,017 (0%) | 0% | 2.2 | 2,674 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 6,873 | 295,249 (0%) | 0% | 2.2 | 14,919 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 6,873 | 302,122 (0%) | 0% | 2.2 | 14,919 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 50,000 | 308,995 (0%) | 0% | 0 | Common Stock | |
| David A. Spellman | SVP, CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 803 | 128,599 (0%) | 0% | 2.2 | 1,743 | Common Stock |
| David A. Spellman | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 60,000 | 129,402 (0%) | 0% | 0 | Common Stock | |
| David A. Spellman | SVP, CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 2.15 per share. | 28 Feb 2022 | 7,400 | 69,402 (0%) | 0% | 2.2 | 15,946 | Common Stock |
| David A. Spellman | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 225,000 | 225,000 | - | - | Employee Stock Option (Right to buy) | |
| Dell Faulkingham | SVP, CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 200,000 | 200,000 | - | - | Employee Stock Option (Right to buy) | |
| Dell Faulkingham | SVP, CCO | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 5,748 | 174,798 (0%) | 0% | 2.2 | 12,477 | Common Stock |
| Dell Faulkingham | SVP, CCO | Sale of securities on an exchange or to another person at price $ 2.15 per share. | 28 Feb 2022 | 6,479 | 130,546 (0%) | 0% | 2.2 | 13,961 | Common Stock |
| Dell Faulkingham | SVP, CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 50,000 | 180,546 (0%) | 0% | 0 | Common Stock | |
| Dell Faulkingham | SVP, CCO | Sale of securities on an exchange or to another person at price $ 2.17 per share. | 28 Feb 2022 | 957 | 173,841 (0%) | 0% | 2.2 | 2,077 | Common Stock |
| Violetta Cotreau | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 70,000 | 70,000 | - | - | Employee Stock Option (Right to buy) | |
| Violetta Cotreau | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 2.15 per share. | 28 Feb 2022 | 3,946 | 29,121 (0%) | 0% | 2.2 | 8,503 | Common Stock |
| Violetta Cotreau | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 40,833 | 69,954 (0%) | 0% | 0 | Common Stock | |
| Violetta Cotreau | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 2.29 per share. | 03 Jan 2022 | 5,833 | 33,067 (0%) | 0% | 2.3 | 13,335 | Common Stock |
| Ron Frieson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2021 | 80,200 | 80,200 | - | - | Stock Option (Right to buy) | |
| David A. Spellman | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2021 | 200,000 | 200,000 | - | - | Employee Stock Option (Right to Buy) | |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 2.83 per share. | 31 Aug 2021 | 1,042 | 171,219 (0%) | 0% | 2.8 | 2,949 | Common Stock |
| Steven C. Gilman | Director | Sale of securities on an exchange or to another person at price $ 3.32 per share. | 07 Jun 2021 | 4,567 | 47,997 (0%) | 0% | 3.3 | 15,163 | Common Stock |
| Adrian Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Adrian Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 13,700 | 91,100 (0%) | 0% | 0 | Common Stock | |
| Steven C. Gilman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 13,700 | 52,564 (0%) | 0% | 0 | Common Stock | |
| Steven C. Gilman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Michael W. Rogers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 13,700 | 52,329 (0%) | 0% | 0 | Common Stock | |
| Michael W. Rogers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Michael T. Heffernan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Michael T. Heffernan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 13,700 | 48,586 (0%) | 0% | 0 | Common Stock | |
| Cynthia Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 13,700 | 51,533 (0%) | 0% | 0 | Common Stock | |
| Cynthia Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Myles Wolf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Myles Wolf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Jun 2021 | 13,700 | 23,981 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 01 Apr 2021 | 4,109 | 1,152,153 (0%) | 0% | 3.4 | 13,971 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 01 Apr 2021 | 1,060 | 272,303 (0%) | 0% | 3.4 | 3,604 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 01 Apr 2021 | 1,081 | 170,761 (0%) | 0% | 3.4 | 3,675 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 01 Apr 2021 | 1,211 | 265,550 (0%) | 0% | 3.4 | 4,117 | Common Stock |
| David A. Spellman | SVP, CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 01 Apr 2021 | 790 | 76,802 (0%) | 0% | 3.4 | 2,686 | Common Stock |
| Dell Faulkingham | SVP, CCO | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 01 Apr 2021 | 952 | 137,025 (0%) | 0% | 3.4 | 3,237 | Common Stock |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Mar 2021 | 39,520 | 1,156,262 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Mar 2021 | 10,192 | 273,363 (0%) | 0% | 0 | Common Stock | |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Mar 2021 | 10,400 | 171,842 (0%) | 0% | 0 | Common Stock | |
| Michel Dahan | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Mar 2021 | 11,648 | 266,761 (0%) | 0% | 0 | Common Stock | |
| David A. Spellman | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Mar 2021 | 7,592 | 77,592 (0%) | 0% | 0 | Common Stock | |
| Dell Faulkingham | CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Mar 2021 | 9,152 | 137,977 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 26 Feb 2021 | 24,674 | 1,116,742 (0%) | 0% | 3.4 | 83,795 | Common Stock |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 403,600 | 403,600 | - | - | Employee Stock Option (Right to buy) | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 237,400 | 1,166,732 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 26 Feb 2021 | 25,316 | 1,141,416 (0%) | 0% | 3.4 | 85,976 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 26 Feb 2021 | 6,309 | 271,147 (0%) | 0% | 3.4 | 21,426 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 62,000 | 277,456 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 110,000 | 110,000 | - | - | Employee Stock Option (Right to buy) | |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 26 Feb 2021 | 7,976 | 263,171 (0%) | 0% | 3.4 | 27,087 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 70,000 | 169,000 (0%) | 0% | 0 | Common Stock | |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 120,000 | 120,000 | - | - | Employee Stock Option (Right to buy) | |
| Steven Keith Burke | SVP, Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 26 Feb 2021 | 7,558 | 161,442 (0%) | 0% | 3.4 | 25,668 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 62,000 | 269,660 (0%) | 0% | 0 | Common Stock | |
| Michel Dahan | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 110,000 | 110,000 | - | - | Employee Stock Option (Right to buy) | |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 26 Feb 2021 | 7,945 | 255,113 (0%) | 0% | 3.4 | 26,982 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 26 Feb 2021 | 6,602 | 263,058 (0%) | 0% | 3.4 | 22,421 | Common Stock |
| David A. Spellman | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 70,000 | 70,000 (0%) | 0% | 0 | Common Stock | |
| David A. Spellman | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 120,000 | 120,000 | - | - | Employee Stock Option (Right to buy) | |
| Dell Faulkingham | CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 110,000 | 110,000 | - | - | Employee Stock Option (Right to buy) | |
| Dell Faulkingham | CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 62,000 | 135,574 (0%) | 0% | 0 | Common Stock | |
| Dell Faulkingham | CCO | Sale of securities on an exchange or to another person at price $ 3.40 per share. | 26 Feb 2021 | 6,749 | 128,825 (0%) | 0% | 3.4 | 22,920 | Common Stock |
| Violetta Cotreau | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 26,000 | 38,900 (0%) | 0% | 0 | Common Stock | |
| Violetta Cotreau | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2021 | 44,200 | 44,200 | - | - | Employee Stock Option (Right to buy) | |
| LeAnne M. Zumwalt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2021 | 80,200 | 80,200 | - | - | Stock Option (Right to buy) | |
| David A. Spellman | SVP, CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Jun 2020 | 280,000 | 280,000 | - | - | Employee Stock Option (Right to buy) | |
| Adrian Adams | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Adrian Adams | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 13,700 | 77,400 (0%) | 0% | 0 | Common Stock | |
| Maxine Gowen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Maxine Gowen | None | Sale of securities on an exchange or to another person at price $ 12.05 per share. | 05 Jun 2020 | 4,567 | 24,133 (0%) | 0% | 12.0 | 55,032 | Common Stock |
| Maxine Gowen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 13,700 | 28,700 (0%) | 0% | 0 | Common Stock | |
| Steven C. Gilman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Steven C. Gilman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 13,700 | 43,431 (0%) | 0% | 0 | Common Stock | |
| Steven C. Gilman | None | Sale of securities on an exchange or to another person at price $ 12.08 per share. | 05 Jun 2020 | 4,567 | 38,864 (0%) | 0% | 12.1 | 55,169 | Common Stock |
| Michael W. Rogers | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 13,700 | 38,629 (0%) | 0% | 0 | Common Stock | |
| Michael W. Rogers | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Michael T. Heffernan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Michael T. Heffernan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 13,700 | 34,886 (0%) | 0% | 0 | Common Stock | |
| Cynthia Smith | None | Sale of securities on an exchange or to another person at price $ 12.10 per share. | 05 Jun 2020 | 4,567 | 37,833 (0%) | 0% | 12.1 | 55,261 | Common Stock |
| Cynthia Smith | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Cynthia Smith | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 13,700 | 42,400 (0%) | 0% | 0 | Common Stock | |
| Mark J. Enyedy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Mark J. Enyedy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2020 | 13,700 | 31,143 (0%) | 0% | 0 | Common Stock | |
| Dell Faulkingham | CCO | Sale of securities on an exchange or to another person at price $ 11.58 per share. | 01 Jun 2020 | 6,426 | 73,574 (0%) | 0% | 11.6 | 74,413 | Common Stock |
| Myles Wolf | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Apr 2020 | 80,200 | 80,200 | - | - | Stock Option (Right to buy) | |
| Jason A. Amello | SVP, CFO & Treasurer | Sale of securities on an exchange or to another person at price $ 8.70 per share. | 28 Feb 2020 | 6,976 | 144,642 (0%) | 0% | 8.7 | 60,691 | Common Stock |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 30,000 | 151,618 (0%) | 0% | 0 | Common Stock | |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 237,400 | 1,026,632 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 403,600 | 403,600 | - | - | Stock Option (Right to buy) | |
| Karen L. Tubridy | SVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 85,000 | 85,000 | - | - | Stock Option (Right to buy) | |
| Karen L. Tubridy | SVP, Chief Development Officer | Sale of securities on an exchange or to another person at price $ 8.70 per share. | 28 Feb 2020 | 3,454 | 84,679 (0%) | 0% | 8.7 | 30,050 | Common Stock |
| Karen L. Tubridy | SVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 30,000 | 88,133 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 62,000 | 219,806 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 8.70 per share. | 28 Feb 2020 | 7,050 | 212,756 (0%) | 0% | 8.7 | 61,335 | Common Stock |
| Nicole R. Hadas | SVP, Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 105,000 | 105,000 | - | - | Stock Option (Right to buy) | |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 105,500 | 105,500 | - | - | Stock Option (Right to buy) | |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 62,000 | 99,000 (0%) | 0% | 0 | Common Stock | |
| Michel Dahan | SVP, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 8.70 per share. | 28 Feb 2020 | 6,972 | 204,960 (0%) | 0% | 8.7 | 60,656 | Common Stock |
| Michel Dahan | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 120,000 | 120,000 | - | - | Stock Option (Right to buy) | |
| Michel Dahan | SVP, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 65,000 | 211,932 (0%) | 0% | 0 | Common Stock | |
| Dell Faulkingham | CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 94,000 | 94,000 | - | - | Stock Option (Right to buy) | |
| Dell Faulkingham | CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2020 | 55,000 | 80,000 (0%) | 0% | 0 | Common Stock | |
| Adrian Adams | Director | Purchase of securities on an exchange or from another person at price $ 3.41 per share. | 20 Nov 2019 | 50,000 | 63,700 (0%) | 0% | 3.4 | 170,500 | Common Stock |
| Steven C. Gilman | Director | Purchase of securities on an exchange or from another person at price $ 3.43 per share. | 20 Nov 2019 | 5,800 | 29,731 (0%) | 0% | 3.4 | 19,894 | Common Stock |
| Cynthia Smith | Director | Purchase of securities on an exchange or from another person at price $ 3.52 per share. | 20 Nov 2019 | 15,000 | 28,700 (0%) | 0% | 3.5 | 52,800 | Common Stock |
| John P. Butler | Director, CEO and President | Purchase of securities on an exchange or from another person at price $ 3.44 per share. | 20 Nov 2019 | 50,000 | 887,732 (0%) | 0% | 3.4 | 172,000 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Purchase of securities on an exchange or from another person at price $ 3.58 per share. | 20 Nov 2019 | 27,000 | 37,000 (0%) | 0% | 3.6 | 96,660 | Common Stock |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Aug 2019 | 250,000 | 250,000 | - | - | Employee Stock Option (Right to buy) | |
| Steven Keith Burke | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Aug 2019 | 10,000 | 10,000 (0%) | 0% | 0 | Common Stock | |
| Adrian Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 13,700 | 13,700 (0%) | 0% | 0 | Common Stock | |
| Adrian Adams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Maxine Gowen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Maxine Gowen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 13,700 | 15,000 (0%) | 0% | 0 | Common Stock | |
| Scott A. Canute | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Scott A. Canute | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 13,700 | 13,700 (0%) | 0% | 0 | Common Stock | |
| Steven C. Gilman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Steven C. Gilman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 13,700 | 23,931 (0%) | 0% | 0 | Common Stock | |
| Michael W. Rogers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 13,700 | 24,929 (0%) | 0% | 0 | Common Stock | |
| Michael W. Rogers | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Michael T. Heffernan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 13,700 | 21,186 (0%) | 0% | 0 | Common Stock | |
| Michael T. Heffernan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Cynthia Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Cynthia Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 13,700 | 13,700 (0%) | 0% | 0 | Common Stock | |
| Mark Joseph Enyedy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Mark Joseph Enyedy | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 13,700 | 17,443 (0%) | 0% | 0 | Common Stock | |
| Jodie P. Morrison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 20,100 | 20,100 | - | - | Stock Option (Right to buy) | |
| Jodie P. Morrison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2019 | 13,700 | 58,619 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2019 | 287,000 | 0 | - | - | Employee Stock Option (Right to buy) | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.47 per share. | 03 Jun 2019 | 287,000 | 836,232 (0%) | 0% | 0.5 | 134,890 | Common Stock |
| Dell Faulkingham | CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2019 | 25,000 | 25,000 (0%) | 0% | 0 | Common Stock | |
| Dell Faulkingham | CCO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2019 | 250,000 | 250,000 | - | - | Employee Stock Option (Right to buy) | |
| Jason A. Amello | SVP, CFO & Treasurer | Sale or transfer of securities back to the company at price $ 7.70 per share. | 11 Apr 2019 | 13,148 | 118,618 (0%) | 0% | 7.7 | 101,240 | Common Stock |
| Karen L. Tubridy | SVP, Chief Development Officer | Sale or transfer of securities back to the company at price $ 7.70 per share. | 11 Apr 2019 | 6,075 | 55,324 (0%) | 0% | 7.7 | 46,778 | Common Stock |
| Nicole R. Hadas | SVP, CLO & Secretary | Sale or transfer of securities back to the company at price $ 7.70 per share. | 11 Apr 2019 | 11,929 | 154,806 (0%) | 0% | 7.7 | 91,853 | Common Stock |
| Michel Dahan | SVP, Chief Business Officer | Sale or transfer of securities back to the company at price $ 7.70 per share. | 11 Apr 2019 | 11,909 | 146,932 (0%) | 0% | 7.7 | 91,699 | Common Stock |
| Rita I. Jain | SVP, Chief Medical Officer | Sale or transfer of securities back to the company at price $ 7.70 per share. | 11 Apr 2019 | 4,409 | 96,332 (0%) | 0% | 7.7 | 33,949 | Common Stock |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 65,000 | 131,766 (0%) | 0% | 0 | Common Stock | |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 100,000 | 100,000 | - | - | Employee Stock Option (Right to buy) | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 350,000 | 350,000 | - | - | Employee Stock Option (Right to buy) | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 239,500 | 614,382 (0%) | 0% | 0 | Common Stock | |
| Karen L. Tubridy | SVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 45,000 | 45,000 | - | - | Employee Stock Option (Right to buy) | |
| Karen L. Tubridy | SVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 30,000 | 61,399 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, CLO & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 65,000 | 166,735 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, CLO & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 100,000 | 100,000 | - | - | Employee Stock Option (Right to buy) | |
| Michel Dahan | SVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 65,000 | 158,841 (0%) | 0% | 0 | Common Stock | |
| Michel Dahan | SVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 100,000 | 100,000 | - | - | Employee Stock Option (Right to buy) | |
| Rita I. Jain | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 115,000 | 115,000 | - | - | Employee Stock Option (Right to buy) | |
| Rita I. Jain | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2019 | 80,000 | 100,741 (0%) | 0% | 0 | Common Stock | |
| Adrian Adams | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 25,000 | 25,000 | - | - | Stock Option (Right to buy) | |
| Steven C. Gilman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 | - | - | Stock Option (Right to buy) | |
| Steven C. Gilman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 25,000 | 25,000 | - | - | Stock Option (Right to buy) | |
| Steven C. Gilman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 | - | - | Stock Option (Right to buy) | |
| Steven C. Gilman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 10,231 | 10,231 (0%) | 0% | 0 | Common Stock | |
| Steven C. Gilman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 18,716 | 18,716 | - | - | Stock Option (Right to buy) | |
| Steven C. Gilman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 | - | - | Stock Option (Right to buy) | |
| Jason A. Amello | SVP, CFO & Treasurer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.94 per share. | 12 Dec 2018 | 22,235 | 66,501 (0%) | 0% | 8.9 | 198,781 | Common Stock |
| Michael W. Rogers | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 | - | - | Stock Option (Right to buy) | |
| Michael W. Rogers | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 | - | - | Stock Option (Right to buy) | |
| Michael W. Rogers | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 25,000 | 25,000 | - | - | Stock Option (Right to buy) | |
| Michael W. Rogers | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 18,716 | 18,716 | - | - | Stock Option (Right to buy) | |
| Michael W. Rogers | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 (0%) | 0% | 0 | Common Stock | |
| Michael W. Rogers | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 | - | - | Stock Option (Right to buy) | |
| Michael T. Heffernan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 25,000 | 25,000 | - | - | Stock Option (Right to buy) | |
| Michael T. Heffernan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 7,486 | 7,486 (0%) | 0% | 0 | Common Stock | |
| Michael T. Heffernan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 18,716 | 18,716 | - | - | Stock Option (Right to buy) | |
| Michael T. Heffernan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 | - | - | Stock Option (Right to buy) | |
| Michael T. Heffernan | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 | - | - | Stock Option (Right to buy) | |
| Mark J. Enyedy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 18,716 | 18,716 | - | - | Stock Option (Right to buy) | |
| Mark J. Enyedy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 | - | - | Stock Option (Right to buy) | |
| Mark J. Enyedy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 3,743 | 3,743 (0%) | 0% | 0 | Common Stock | |
| Mark J. Enyedy | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 25,000 | 25,000 | - | - | Stock Option (Right to buy) | |
| John P. Butler | Director, CEO & President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.94 per share. | 12 Dec 2018 | 135,697 | 374,617 (0%) | 0% | 8.9 | 1,213,131 | Common Stock |
| Karen L. Tubridy | SVP, Chief Development Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.94 per share. | 12 Dec 2018 | 11,928 | 30,229 (0%) | 0% | 8.9 | 106,636 | Common Stock |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.94 per share. | 12 Dec 2018 | 20,175 | 101,284 (0%) | 0% | 8.9 | 180,365 | Common Stock |
| Jodie P. Morrison | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 | - | - | Stock Option (Right to buy) | |
| Jodie P. Morrison | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 18,716 | 18,716 | - | - | Stock Option (Right to buy) | |
| Jodie P. Morrison | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 44,919 | 44,919 (0%) | 0% | 0 | Common Stock | |
| Jodie P. Morrison | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 25,000 | 25,000 | - | - | Stock Option (Right to buy) | |
| Jodie P. Morrison | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2018 | 11,229 | 11,229 | - | - | Stock Option (Right to buy) | |
| Michel Dahan | SVP, Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.94 per share. | 12 Dec 2018 | 23,385 | 93,841 (0%) | 0% | 8.9 | 209,062 | Common Stock |
| Rita I. Jain | SVP, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 8.94 per share. | 12 Dec 2018 | 8,659 | 20,741 (0%) | 0% | 8.9 | 77,411 | Common Stock |
| Cynthia Smith | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Aug 2018 | 25,000 | 25,000 | - | - | Stock Option (Right to buy) | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.47 per share. | 11 Jul 2018 | 100,000 | 510,314 (0%) | 0% | 0.5 | 47,000 | Common Stock |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jul 2018 | 100,000 | 287,000 | - | - | Employee Stock Option (Right to buy) | |
| Maxine Gowen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2018 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Michael Stephen Wyzga | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2018 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Ronald C. Renaud | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2018 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Scott A. Canute | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2018 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Muneer A. Satter | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2018 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Duane D. Nash | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2018 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Michael D. Clayman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2018 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 27,700 | 27,700 | - | - | Employee Stock Option (Right to buy) | |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 19,500 | 87,236 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 88,900 | 408,814 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 126,300 | 126,300 | - | - | Employee Stock Option (Right to buy) | |
| Karen L. Tubridy | SVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 25,000 | 25,000 | - | - | Employee Stock Option (Right to buy) | |
| Karen L. Tubridy | SVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 17,500 | 41,518 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 25,000 | 25,000 | - | - | Employee Stock Option (Right to buy) | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 17,500 | 120,078 (0%) | 0% | 0 | Common Stock | |
| Michel Dahan | SVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 27,500 | 27,500 | - | - | Employee Stock Option (Right to buy) | |
| Michel Dahan | SVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 19,400 | 115,226 (0%) | 0% | 0 | Common Stock | |
| Rita I. Jain | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 29,400 | 29,400 (0%) | 0% | 0 | Common Stock | |
| Rita I. Jain | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2018 | 41,800 | 41,800 | - | - | Employee Stock Option (Right to buy) | |
| Duane D. Nash | None | Sale of securities on an exchange or to another person at price $ 14.62 per share. | 15 Feb 2018 | 1,000 | 21,499 (0%) | 0% | 14.6 | 14,620 | Common Stock |
| Duane D. Nash | None | Sale of securities on an exchange or to another person at price $ 19.64 per share. | 02 Oct 2017 | 1,188 | 22,499 (0%) | 0% | 19.6 | 23,332 | Common Stock |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 19.95 per share. | 02 Oct 2017 | 6,250 | 101,804 (0%) | 0% | 20.0 | 124,688 | Common Stock |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 19.64 per share. | 02 Oct 2017 | 1,553 | 108,054 (0%) | 0% | 19.6 | 30,501 | Common Stock |
| Michel Dahan | SVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 19.64 per share. | 02 Oct 2017 | 1,398 | 95,826 (0%) | 0% | 19.6 | 27,457 | Common Stock |
| Michel Dahan | SVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 19.30 per share. | 28 Sep 2017 | 5,000 | 97,224 (0%) | 0% | 19.3 | 96,500 | Common Stock |
| Michel Dahan | SVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 15.00 per share. | 15 Aug 2017 | 5,000 | 102,224 (0%) | 0% | 15 | 75,000 | Common Stock |
| Muneer A. Satter | None | Purchase of securities on an exchange or from another person at price $ 14.50 per share. | 05 Jul 2017 | 1,034,482 | 3,037,042 (7%) | 2% | 14.5 | 14,999,989 | Common Stock |
| Duane D. Nash | None | Sale of securities on an exchange or to another person at price $ 14.27 per share. | 03 Jul 2017 | 990 | 23,687 (0%) | 0% | 14.3 | 14,127 | Common Stock |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 14.26 per share. | 03 Jul 2017 | 1,554 | 109,607 (0%) | 0% | 14.3 | 22,156 | Common Stock |
| Michel Dahan | SVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 14.26 per share. | 03 Jul 2017 | 1,399 | 107,224 (0%) | 0% | 14.3 | 19,947 | Common Stock |
| Maxine Gowen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Michael Stephen Wyzga | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Ronald C. Renaud | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Scott A. Canute | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Muneer A. Satter | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Duane D. Nash | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Michael D. Clayman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jun 2017 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Rita I. Jain | SVP, Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 May 2017 | 200,000 | 200,000 | - | - | Stock Option (Right to buy) | |
| Duane D. Nash | None | Sale of securities on an exchange or to another person at price $ 9.20 per share. | 03 Apr 2017 | 991 | 24,677 (0%) | 0% | 9.2 | 9,119 | Common Stock |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 9.18 per share. | 03 Apr 2017 | 1,556 | 109,856 (0%) | 0% | 9.2 | 14,280 | Common Stock |
| Michel Dahan | SVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 9.18 per share. | 03 Apr 2017 | 1,401 | 108,623 (0%) | 0% | 9.2 | 12,858 | Common Stock |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 47,500 | 47,500 | - | - | Stock Option (Right to buy) | |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 30,000 | 65,637 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 119,500 | 317,780 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 190,000 | 190,000 | - | - | Stock Option (Right to buy) | |
| Karen L. Tubridy | SVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 36,500 | 36,500 | - | - | Stock Option (Right to buy) | |
| Karen L. Tubridy | SVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 23,000 | 23,000 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 28,500 | 111,412 (0%) | 0% | 0 | Common Stock | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 45,000 | 45,000 | - | - | Stock Option (Right to buy) | |
| Bradley Maroni | SVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 23,500 | 64,585 (0%) | 0% | 0 | Common Stock | |
| Bradley Maroni | SVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 37,500 | 37,500 | - | - | Stock Option (Right to buy) | |
| Michel Dahan | SVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 62,500 | 62,500 | - | - | Stock Option (Right to buy) | |
| Michel Dahan | SVP, Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Feb 2017 | 39,500 | 110,024 (0%) | 0% | 0 | Common Stock | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.47 per share. | 19 Jan 2017 | 20,000 | 373,480 (0%) | 0% | 0.5 | 9,400 | Common Stock |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Jan 2017 | 20,000 | 387,000 | - | - | Stock Option (Right to buy) | |
| Duane D. Nash | None | Sale of securities on an exchange or to another person at price $ 10.46 per share. | 03 Jan 2017 | 1,980 | 25,668 (0%) | 0% | 10.5 | 20,711 | Common Stock |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 10.49 per share. | 01 Jan 2017 | 1,810 | 82,912 (0%) | 0% | 10.5 | 18,988 | Common Stock |
| Michel Dahan | SVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 10.49 per share. | 01 Jan 2017 | 1,629 | 70,524 (0%) | 0% | 10.5 | 17,089 | Common Stock |
| John P. Butler | Director, CEO and President | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2016 | 58,400 | 58,400 | - | - | Common Stock | |
| John P. Butler | Director, CEO and President | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2016 | 116,800 | 198,280 | - | - | Common Stock | |
| Karen L. Tubridy | SVP, Chief Development Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Nov 2016 | 130,000 | 130,000 | - | - | Stock Option (Right to buy) | |
| Duane D. Nash | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 Oct 2016 | 1,981 | 27,648 | - | - | Common Stock | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Oct 2016 | 1,556 | 83,915 | - | - | Common Stock | |
| Michel Dahan | SVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Oct 2016 | 1,401 | 72,153 | - | - | Common Stock | |
| Scott A. Canute | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jul 2016 | 25,000 | 25,000 | - | - | Stock Option (Right to buy) | |
| Duane D. Nash | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 06 Jul 2016 | 1,980 | 29,629 | - | - | Common Stock | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Jul 2016 | 1,557 | 85,471 | - | - | Common Stock | |
| Michel Dahan | SVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Jul 2016 | 1,402 | 73,554 | - | - | Common Stock | |
| Michael S. Wyzga | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Muneer A. Satter | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Ronald C. Renaud | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Maxine Gowen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Duane D. Nash | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Michael D. Clayman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Anupam Dalal | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2016 | 12,500 | 12,500 | - | - | Stock Option (Right to buy) | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Apr 2016 | 1,556 | 85,528 | - | - | Common Stock | |
| Michel Dahan | SVP, Chief Business Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Apr 2016 | 1,401 | 74,956 | - | - | Common Stock | |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2016 | 26,000 | 33,330 | - | - | Common Stock | |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2016 | 39,650 | 39,650 | - | - | Stock Option (Right to Buy) | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2016 | 125,500 | 351,173 | - | - | Common Stock | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2016 | 190,550 | 190,550 | - | - | Stock Option (Right to Buy) | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2016 | 22,500 | 87,084 | - | - | Common Stock | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2016 | 34,300 | 34,300 | - | - | Stock Option (Right to Buy) | |
| Bradley Maroni | SVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2016 | 36,500 | 38,859 | - | - | Common Stock | |
| Bradley Maroni | SVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Feb 2016 | 55,850 | 55,850 | - | - | Stock Option (Right to Buy) | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2016 | 25,000 | 225,673 | - | - | Common Stock | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2016 | 25,000 | 407,000 | - | - | Stock Option (Right to Buy) | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jan 2016 | 1,811 | 64,584 | - | - | Common Stock | |
| Duane D. Nash | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Oct 2015 | 996 | 31,609 | - | - | Common Stock | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Oct 2015 | 1,484 | 65,260 | - | - | Common Stock | |
| Duane D. Nash | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jul 2015 | 996 | 32,605 | - | - | Common Stock | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jul 2015 | 1,484 | 66,744 | - | - | Common Stock | |
| Michael S. Wyzga | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2015 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Muneer A. Satter | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2015 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Ronald C. Renaud | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2015 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Maxine Gowen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2015 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Duane D. Nash | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2015 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Michael D. Clayman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2015 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Anupam Dalal | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jun 2015 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 May 2015 | 50,000 | 0 | - | - | Stock Option (Right to Buy) | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 May 2015 | 50,000 | 198,350 | - | - | Common Stock | |
| Muneer A. Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 22 Apr 2015 | 420,000 | 2,002,560 | - | - | Common Stock | |
| Duane D. Nash | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Apr 2015 | 1,980 | 13,012 | - | - | Common Stock | |
| Duane D. Nash | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Apr 2015 | 996 | 12,016 | - | - | Common Stock | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Apr 2015 | 1,483 | 67,015 | - | - | Common Stock | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2015 | 100,000 | 0 | - | - | Stock Option (Right to Buy) | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Mar 2015 | 100,000 | 148,350 | - | - | Common Stock | |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2015 | 45,000 | 45,000 | - | - | Stock Option (Right to Buy) | |
| John P. Butler | Director, CEO and President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2015 | 150,000 | 150,000 | - | - | Stock Option (Right to Buy) | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2015 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Bradley Maroni | SVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Mar 2015 | 85,000 | 85,000 | - | - | Stock Option (Right to Buy) | |
| Duane D. Nash | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jan 2015 | 1,980 | 13,809 | - | - | Common Stock | |
| Duane D. Nash | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jan 2015 | 995 | 12,814 | - | - | Common Stock | |
| Nicole R. Hadas | SVP, General Counsel, Sec. | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jan 2015 | 1,715 | 68,498 | - | - | Common Stock | |
| John P. Butler | Director, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 29 Dec 2014 | 1,000 | 48,350 | - | - | Common Stock | |
| Duane Nash | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Dec 2014 | 23,762 | 23,762 | - | - | Common Stock | |
| Duane Nash | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 23 Dec 2014 | 6,764 | 16,998 | - | - | Common Stock | |
| Duane Nash | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 23 Dec 2014 | 5,169 | 11,829 | - | - | Common Stock | |
| Duane Nash | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Dec 2014 | 23,762 | 23,762 | - | - | Common Stock | |
| Duane Nash | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 23 Dec 2014 | 6,764 | 16,998 | - | - | Common Stock | |
| Duane Nash | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 23 Dec 2014 | 5,169 | 11,829 | - | - | Common Stock | |
| John P. Butler | Director, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 22 Dec 2014 | 1,000 | 47,350 | - | - | Common Stock | |
| John P. Butler | Director, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 15 Dec 2014 | 1,000 | 46,350 | - | - | Common Stock | |
| Ronald C. Renaud | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 02 Dec 2014 | 5,000 | 5,000 | - | - | Common Stock | |
| Nicole R. Hadas | VP General Counsel & Secretary | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 02 Dec 2014 | 5,910 | 70,213 | - | - | Common Stock | |
| Jason A. Amello | SVP, CFO & Treasurer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 26 Nov 2014 | 1,000 | 5,000 | - | - | Common Stock | |
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 25 Nov 2014 | 5,000 | 1,582,560 | - | - | Common Stock | |
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 24 Nov 2014 | 5,000 | 1,577,560 | - | - | Common Stock | |
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 21 Nov 2014 | 5,000 | 1,572,560 | - | - | Common Stock | |
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 20 Nov 2014 | 5,000 | 1,567,560 | - | - | Common Stock | |
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 19 Nov 2014 | 5,000 | 1,562,560 | - | - | Common Stock | |
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 18 Nov 2014 | 5,000 | 1,557,560 | - | - | Common Stock | |
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 17 Nov 2014 | 5,000 | 1,552,560 | - | - | Common Stock | |
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Nov 2014 | 5,000 | 1,547,560 | - | - | Common Stock | |
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 13 Nov 2014 | 5,000 | 1,542,560 | - | - | Common Stock | |
| Maxine Gowen | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 13 Nov 2014 | 1,300 | 1,300 | - | - | Common Stock | |
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 12 Nov 2014 | 1,100 | 1,533,660 | - | - | Common Stock | |
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 12 Nov 2014 | 3,900 | 1,537,560 | - | - | Common Stock | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Nov 2014 | 30,500 | 0 | - | - | Stock Option (right to buy) | |
| John P. Butler | Director, CEO and President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Nov 2014 | 30,500 | 44,350 | - | - | Common Stock | |
| John P. Butler | Director, CEO and President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 11 Nov 2014 | 1,000 | 45,350 | - | - | Common Stock | |
| Ronald C. Renaud | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Sep 2014 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Bradley Maroni | SVP & Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Aug 2014 | 125,000 | 125,000 | - | - | Stock Option (Right to Buy) | |
| Maxine Gowen | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jul 2014 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Michael D. Clayman | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Jul 2014 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Jason A. Amello | SVP, CFO & Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2014 | 21,667 | 21,667 | - | - | Stock Option (Right to Buy) | |
| John P. Butler | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2014 | 46,667 | 46,667 | - | - | Stock Option (Right to Buy) | |
| Robert Shalwitz | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2014 | 21,667 | 21,667 | - | - | Stock Option (Right to Buy) | |
| Nicole R. Hadas | VP General Counsel & Secretary | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2014 | 16,667 | 16,667 | - | - | Stock Option (Right to Buy) | |
| Michael S. Wyzga | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 25 Mar 2014 | 1,500 | 1,500 | - | - | Common Stock | |
| Muneer Satter | None | 25 Mar 2014 | 260,873 | 0 | - | - | Series B Convertible Preferred Stock | ||
| Muneer Satter | None | 25 Mar 2014 | 525,021 | 0 | - | - | Series C Convertible Preferred Stock | ||
| Muneer Satter | None | 25 Mar 2014 | 1,441,265 | 1,441,265 | - | - | Common Stock | ||
| Muneer Satter | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 25 Mar 2014 | 91,295 | 1,532,560 | - | - | Common Stock | |
| Jason A. Amello | SVP, CFO & Treasurer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 25 Mar 2014 | 4,000 | 4,000 | - | - | Common Stock | |
| John P. Butler | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 25 Mar 2014 | 13,850 | 13,850 | - | - | Common Stock |